MutSig and its evolving algorithms have existed since
                    the youth of clinical sequencing, with early versions
                    used in multiple publications.

"Three significance metrics [are] calculated for each
                    gene, using the [&hellip;] methods MutSigCV

Getz G, H&ouml;fling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, Lander ES

Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Integrated genomic analyses of ovarian carcinoma

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

Discovery and saturation analysis of cancer genes across 21 tumour types

Mutation Analysis (MutSig 2CV v3.1 hg38 beta)