feature type start end label R G B shape direction protein Name=APC {ECO:0000312|HGNC:HGNC:583}; Synonyms=DP2.5; 1 2843 Name=APC {ECO:0000312|HGNC:HGNC:583}; Synonyms=DP2.5; 0.7 0.9 0.9 - - domain Adenomatous polyposis coli protein. 2 2843 Adenomatous polyposis coli protein. 0.36 0.48 0.78 - - domain Responsible for down-regulation through a process mediated by direct ubiquitination. 960 1337 Responsible for down-regulation through a process mediated by direct ubiquitination. 0.48 0.76 0.61 - - domain Highly charged. 1866 1893 Highly charged. 0.49 0.42 0.45 - - domain Microtubule tip localization signal. 2803 2806 Microtubule tip localization signal. 0.23 0.46 0.21 - - domain PDZ-binding. 2841 2843 PDZ-binding. 0.28 0.78 0.25 - - mutation Nonsense_Mutation 129 129 p.E129* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 232 232 p.R232* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 415 415 p.A415T 1.0 1.0 0.0 circle up mutation Missense_Mutation 418 418 p.E418K 1.0 1.0 0.0 circle up mutation Missense_Mutation 522 522 p.M522I 1.0 1.0 0.0 circle up mutation Missense_Mutation 937 937 p.F937V 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 943 943 p.S943* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 947 947 p.C947S 1.0 1.0 0.0 circle up mutation Missense_Mutation 981 981 p.P981L 1.0 1.0 0.0 circle up mutation Missense_Mutation 1099 1099 p.V1099I 1.0 1.0 0.0 circle up mutation Missense_Mutation 1173 1173 p.V1173L 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 1322 1322 p.E1322Kfs*93 1.0 0.0 0.0 square up mutation Nonsense_Mutation 1338 1338 p.Q1338* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 1450 1450 p.R1450* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 1450 1450 p.R1450* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 1450 1450 p.R1450* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 1464 1464 p.E1464K 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 1545 1545 p.S1545* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Ins 1556 1556 p.T1556Nfs*3 1.0 0.0 0.0 square up mutation Missense_Mutation 1742 1742 p.R1742C 1.0 1.0 0.0 circle up mutation Missense_Mutation 1861 1861 p.S1861Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 1861 1861 p.S1861Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 1864 1864 p.S1864Y 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 1878 1878 p.K1878Rfs*4 1.0 0.0 0.0 square up mutation Nonsense_Mutation 1920 1920 p.R1920* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 1971 1971 p.S1971Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 2029 2029 p.S2029Y 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 2194 2194 p.V2194Ffs*5 1.0 0.0 0.0 square up mutation Nonsense_Mutation 2237 2237 p.R2237* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 2338 2338 p.P2338H 1.0 1.0 0.0 circle up mutation Missense_Mutation 2571 2571 p.S2571F 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 2572 2572 p.S2572* 1.0 0.0 0.0 triangle up mutation Silent 2632 2632 p.S2632S 0.8 0.8 0.8 circle up mutation Frame_Shift_Del 2648 2648 p.A2648Hfs*12 1.0 0.0 0.0 square up mutation Missense_Mutation 2679 2679 p.T2679N 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 2719 2719 p.E2719* 1.0 0.0 0.0 square up mutation Missense_Mutation 2768 2768 p.S2768G 1.0 1.0 0.0 circle up mutation Missense_Mutation 2796 2796 p.D2796Y 1.0 1.0 0.0 circle up