feature type start end label R G B shape direction protein Name=FLT3; Synonyms=CD135, FLK2, STK1; 1 993 Name=FLT3; Synonyms=CD135, FLK2, STK1; 0.7 0.9 0.9 - - domain Receptor-type tyrosine-protein kinase FLT3. 27 993 Receptor-type tyrosine-protein kinase FLT3. 0.43 0.22 0.38 - - domain ATP. {ECO:0000255|PROSITE- ProRule:PRU00159}. 616 624 ATP. {ECO:0000255|PROSITE- ProRule:PRU00159}. 0.25 0.61 0.48 - - domain Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. 591 597 Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. 0.56 0.49 0.62 - - mutation Nonsense_Mutation 993 993 p.S993* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 978 978 p.E978D 1.0 1.0 0.0 circle up mutation Missense_Mutation 949 949 p.D949N 1.0 1.0 0.0 circle up mutation Missense_Mutation 736 736 p.S736R 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 669 669 p.G669* 1.0 0.0 0.0 triangle up mutation Splice_Site 648 648 p.X648_splice 0.6 0.0 0.6 inv_triangle up mutation Missense_Mutation 610 610 p.L610F 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 599 599 p.Y599* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 590 590 p.F590C 1.0 1.0 0.0 circle up mutation Missense_Mutation 552 552 p.L552P 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 481 481 p.G481* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 473 473 p.N473D 1.0 1.0 0.0 circle up mutation Missense_Mutation 432 432 p.T432M 1.0 1.0 0.0 circle up mutation Missense_Mutation 225 225 p.F225C 1.0 1.0 0.0 circle up mutation Missense_Mutation 189 189 p.V189I 1.0 1.0 0.0 circle up mutation Missense_Mutation 80 80 p.A80T 1.0 1.0 0.0 circle up