Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.101 0.257 -9999.0 0.0 -0.623 82.0 82.0 IHH -0.014 0.093 -9999.0 0.0 -0.482 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.289 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.055 0.172 -9999.0 0.0 -0.44 60.0 60.0 SMO -0.066 0.18 -9999.0 0.0 -0.466 61.0 61.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.505 22.0 22.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.02 0.124 -9999.0 0.0 -0.382 50.0 50.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.178 -9999.0 0.0 -0.46 61.0 61.0 STIL -0.052 0.148 -9999.0 0.0 -0.37 53.0 53.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.028 0.126 -9999.0 0.0 -0.311 48.0 48.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.121 0.312 -9999.0 0.0 -0.757 81.0 81.0 determination of left/right symmetry -0.065 0.178 -9999.0 0.0 -0.46 61.0 61.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 skeletal system development -0.119 0.308 -9999.0 0.0 -0.747 81.0 81.0 IHH N/Hhip 0.004 0.068 -9999.0 0.0 -0.315 18.0 18.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.178 -9999.0 0.0 -0.46 61.0 61.0 pancreas development 0.011 0.052 -9999.0 0.0 -0.326 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.005 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.065 0.178 -9999.0 0.0 -0.46 61.0 61.0 SHH Np/Cholesterol/PTCH1 -0.049 0.143 -9999.0 0.0 -0.358 49.0 49.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.276 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.334 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.142 -9999.0 0.0 -0.33 76.0 76.0 SMO/Vitamin D3 -0.061 0.167 -9999.0 0.0 -0.397 67.0 67.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.278 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.483 183.0 183.0 receptor-mediated endocytosis -0.12 0.198 -9999.0 0.0 -0.447 99.0 99.0 SHH Np/Cholesterol/BOC -0.027 0.116 -9999.0 0.0 -0.283 85.0 85.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.047 0.145 -9999.0 0.0 -0.358 49.0 49.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.412 27.0 27.0 IHH N/PTCH1 -0.04 0.145 -9999.0 0.0 -0.332 76.0 76.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.043 0.143 -9999.0 0.0 -0.331 76.0 76.0 HHIP 0.011 0.052 -9999.0 0.0 -0.327 11.0 11.0