E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.17 -9999.0 0.0 -0.417 74.0 74.0 KLHL20 -0.018 0.103 0.229 7.0 -0.256 25.0 32.0 CYFIP2 -0.008 0.132 -9999.0 0.0 -0.429 45.0 45.0 Rac1/GDP -0.029 0.124 0.27 6.0 -0.269 64.0 70.0 ENAH -0.065 0.166 -9999.0 0.0 -0.412 69.0 69.0 AP1M1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 RAP1B 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 RAP1A 0.03 0.046 -9999.0 0.0 -0.429 5.0 5.0 CTNNB1 0.022 0.071 -9999.0 0.0 -0.429 12.0 12.0 CDC42/GTP -0.011 0.087 -9999.0 0.0 -0.257 8.0 8.0 ABI1/Sra1/Nap1 -0.046 0.057 -9999.0 0.0 -0.169 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.029 0.108 -9999.0 0.0 -0.238 63.0 63.0 RAPGEF1 -0.065 0.16 0.238 3.0 -0.372 78.0 81.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.429 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.071 0.186 -9999.0 0.0 -0.369 129.0 129.0 CRK -0.064 0.167 -9999.0 0.0 -0.394 83.0 83.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.101 -9999.0 0.0 -0.265 49.0 49.0 alphaE/beta7 Integrin 0.045 0.035 -9999.0 0.0 -0.307 4.0 4.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.429 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.057 -9999.0 0.0 -0.233 15.0 15.0 DLG1 -0.075 0.176 -9999.0 0.0 -0.413 83.0 83.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.057 -9999.0 0.0 -0.178 17.0 17.0 MLLT4 0.024 0.059 -9999.0 0.0 -0.429 8.0 8.0 ARF6/GTP/NME1/Tiam1 0.052 0.048 -9999.0 0.0 -0.24 10.0 10.0 PI3K -0.034 0.074 -9999.0 0.0 -0.229 17.0 17.0 ARF6 0.032 0.03 -9999.0 0.0 -0.429 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.006 0.107 -9999.0 0.0 -0.312 49.0 49.0 TIAM1 0.027 0.058 -9999.0 0.0 -0.429 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.028 0.099 -9999.0 0.0 -0.223 60.0 60.0 AKT1 -0.02 0.055 0.156 5.0 -0.166 6.0 11.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 CDH1 -0.014 0.134 -9999.0 0.0 -0.429 47.0 47.0 RhoA/GDP -0.031 0.127 0.27 6.0 -0.275 65.0 71.0 actin cytoskeleton organization -0.011 0.08 0.172 15.0 -0.186 24.0 39.0 CDC42/GDP -0.028 0.124 0.27 6.0 -0.268 63.0 69.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.007 0.078 -9999.0 0.0 -0.223 52.0 52.0 ITGB7 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.106 -9999.0 0.0 -0.238 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.09 -9999.0 0.0 -0.22 59.0 59.0 mol:GDP -0.048 0.13 0.271 6.0 -0.306 65.0 71.0 CDC42/GTP/IQGAP1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 p120 catenin/RhoA/GDP -0.025 0.133 0.277 6.0 -0.282 64.0 70.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.034 -9999.0 0.0 -0.307 4.0 4.0 RHOA 0.025 0.062 -9999.0 0.0 -0.429 9.0 9.0 CDC42 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.029 0.081 0.137 3.0 -0.19 80.0 83.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.077 0.178 -9999.0 0.0 -0.412 86.0 86.0 regulation of cell-cell adhesion -0.018 0.071 -9999.0 0.0 -0.207 13.0 13.0 WASF2 -0.012 0.046 0.104 8.0 -0.11 15.0 23.0 Rap1/GTP -0.013 0.096 0.245 1.0 -0.28 9.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.106 -9999.0 0.0 -0.231 53.0 53.0 CCND1 -0.036 0.099 0.157 3.0 -0.236 80.0 83.0 VAV2 -0.062 0.196 -9999.0 0.0 -0.569 21.0 21.0 RAP1/GDP -0.016 0.108 0.259 2.0 -0.286 14.0 16.0 adherens junction assembly -0.073 0.173 -9999.0 0.0 -0.399 86.0 86.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.023 0.103 -9999.0 0.0 -0.222 65.0 65.0 E-cadherin/beta catenin -0.026 0.104 -9999.0 0.0 -0.293 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.077 0.177 -9999.0 0.0 -0.411 86.0 86.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 Rac1/GTP -0.078 0.135 -9999.0 0.0 -0.41 33.0 33.0 E-cadherin/beta catenin/alpha catenin 0.017 0.106 -9999.0 0.0 -0.26 59.0 59.0 ITGAE 0.028 0.042 -9999.0 0.0 -0.429 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.073 0.19 -9999.0 0.0 -0.384 121.0 121.0