Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.198 -9999.0 0.0 -0.603 52.0 52.0 IHH 0.015 0.089 -9999.0 0.0 -0.331 18.0 18.0 SHH Np/Cholesterol/GAS1 -0.028 0.108 -9999.0 0.0 -0.242 99.0 99.0 LRPAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.028 0.108 0.241 99.0 -9999.0 0.0 99.0 SMO/beta Arrestin2 -0.019 0.17 -9999.0 0.0 -0.421 53.0 53.0 SMO -0.04 0.162 -9999.0 0.0 -0.434 54.0 54.0 AKT1 -0.011 0.151 -9999.0 0.0 -0.577 24.0 24.0 ARRB2 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.097 -9999.0 0.0 -0.429 23.0 23.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.161 -9999.0 0.0 -0.428 54.0 54.0 STIL -0.008 0.134 0.202 58.0 -0.258 60.0 118.0 DHH N/PTCH2 0.051 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.001 0.118 -9999.0 0.0 -0.29 69.0 69.0 PIK3CA 0.032 0.023 -9999.0 0.0 -0.429 1.0 1.0 DHH 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.067 0.255 -9999.0 0.0 -0.743 55.0 55.0 determination of left/right symmetry -0.037 0.161 -9999.0 0.0 -0.428 54.0 54.0 PIK3R1 0.017 0.084 -9999.0 0.0 -0.429 17.0 17.0 skeletal system development -0.066 0.251 -9999.0 0.0 -0.734 55.0 55.0 IHH N/Hhip 0.032 0.065 -9999.0 0.0 -0.292 12.0 12.0 DHH N/Hhip 0.048 0.03 -9999.0 0.0 -0.307 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.161 -9999.0 0.0 -0.428 54.0 54.0 pancreas development 0.031 0.036 -9999.0 0.0 -0.428 3.0 3.0 HHAT -0.018 0.137 -9999.0 0.0 -0.429 50.0 50.0 PI3K 0.033 0.066 -9999.0 0.0 -0.307 17.0 17.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.031 0.16 -9999.0 0.0 -0.429 70.0 70.0 somite specification -0.037 0.161 -9999.0 0.0 -0.428 54.0 54.0 SHH Np/Cholesterol/PTCH1 -0.031 0.11 -9999.0 0.0 -0.238 100.0 100.0 SHH Np/Cholesterol/PTCH2 0.002 0.076 -9999.0 0.0 -0.235 45.0 45.0 SHH Np/Cholesterol/Megalin -0.06 0.143 -9999.0 0.0 -0.28 137.0 137.0 SHH -0.017 0.093 -9999.0 0.0 -0.307 46.0 46.0 catabolic process -0.028 0.122 -9999.0 0.0 -0.324 69.0 69.0 SMO/Vitamin D3 -0.028 0.146 -9999.0 0.0 -0.333 63.0 63.0 SHH Np/Cholesterol/Hhip 0.001 0.077 -9999.0 0.0 -0.235 46.0 46.0 LRP2 -0.103 0.21 -9999.0 0.0 -0.429 147.0 147.0 receptor-mediated endocytosis -0.076 0.176 -9999.0 0.0 -0.372 92.0 92.0 SHH Np/Cholesterol/BOC -0.009 0.088 -9999.0 0.0 -0.234 64.0 64.0 SHH Np/Cholesterol/CDO -0.008 0.086 -9999.0 0.0 -0.243 56.0 56.0 mesenchymal cell differentiation -0.001 0.077 0.234 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.01 0.131 0.202 51.0 -0.238 100.0 151.0 IHH N/PTCH2 0.035 0.06 -9999.0 0.0 -0.277 10.0 10.0 CDON 0.018 0.074 -9999.0 0.0 -0.429 13.0 13.0 IHH N/PTCH1 -0.008 0.13 -9999.0 0.0 -0.326 69.0 69.0 Megalin/LRPAP1 -0.056 0.162 -9999.0 0.0 -0.306 147.0 147.0 PTCH2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.007 0.072 -9999.0 0.0 -0.233 46.0 46.0 PTCH1 -0.028 0.122 -9999.0 0.0 -0.325 69.0 69.0 HHIP 0.031 0.036 -9999.0 0.0 -0.429 3.0 3.0