rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 225 ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA2B(4), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), C5AR1(1), CALCR(5), CALCRL(3), CCKAR(2), CCKBR(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CRHR1(2), CRHR2(2), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), GABBR1(1), GABBR2(2), GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), GABRB1(3), GABRB2(5), GABRD(2), GABRE(4), GABRG2(4), GABRP(1), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(3), GH2(2), GHR(2), GHRHR(3), GHSR(2), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(4), GLRA3(3), GLRB(3), GPR156(1), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(6), GRIA2(3), GRIA3(8), GRIA4(7), GRID1(10), GRID2(12), GRIK1(4), GRIK2(8), GRIK3(7), GRIK4(3), GRIK5(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRIN3A(7), GRIN3B(4), GRM1(10), GRM2(2), GRM4(1), GRM6(4), GRM7(8), GRM8(8), GRPR(2), GZMA(4), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HRH4(3), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LEPR(10), LHB(1), LHCGR(7), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(1), MC5R(3), MCHR1(2), MCHR2(3), MTNR1A(1), NMBR(2), NMUR2(1), NPBWR1(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY4(1), P2RY6(1), PARD3(5), PPYR1(3), PRL(1), PRLHR(1), PRLR(5), PRSS1(3), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(3), RXFP1(7), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SSTR5(1), TAAR1(4), TAAR2(2), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(2), TACR1(2), TACR3(3), TBXA2R(2), THRA(1), THRB(1), TRHR(1), TRPV1(2), TSHR(1) 56455370 526 161 525 172 145 179 113 31 58 0 1.89e-09 1.17e-06 2 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCBP2(3), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CCRL1(2), CCRL2(1), CHML(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), GALR1(3), GALT(1), GHSR(2), GPR17(3), GPR174(4), GPR27(1), GPR35(1), GPR37(2), GPR37L1(2), GPR50(4), GPR6(2), GPR63(2), GPR77(3), GPR83(2), GPR85(2), GPR87(4), GRPR(2), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LHCGR(7), MAS1(3), MC3R(2), MC4R(1), MC5R(3), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPN1SW(1), OPN3(1), OPRD1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(4), OR1F1(1), OR1Q1(2), OR2H1(1), OR5V1(1), OXTR(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY6(1), PPYR1(3), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RGR(1), RHO(1), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(1) 32196462 273 134 273 97 70 95 61 15 32 0 0.000019 0.0058 3 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(3), AGT(1), AGTR1(2), AGTR2(3), ANPEP(5), CMA1(2), CPA3(4), CTSA(2), CTSG(3), ENPEP(7), LNPEP(2), MAS1(3), MME(8), NLN(2), THOP1(1) 5741924 52 46 52 14 10 21 8 4 9 0 0.0012 0.24 4 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3) 7002876 69 51 69 27 15 25 22 3 4 0 0.0026 0.39 5 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), PRKCE(3) 1635108 20 19 20 4 8 7 3 0 2 0 0.0046 0.39 6 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 130 ACTB(1), COL11A2(10), COL17A1(4), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COMP(1), DES(2), DSC1(5), DSC2(1), DSC3(6), DSG1(8), DSG2(2), DSG3(3), DSG4(5), FN1(16), GJA1(4), GJA10(5), GJA8(3), GJA9(1), GJB2(1), GJB4(1), GJC1(2), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(4), INA(2), ITGA6(3), ITGB4(6), KRT1(1), KRT10(1), KRT12(3), KRT13(2), KRT14(1), KRT16(3), KRT17(2), KRT18(2), KRT2(4), KRT20(2), KRT23(2), KRT24(3), KRT27(2), KRT28(1), KRT3(2), KRT31(1), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT4(1), KRT5(1), KRT6A(1), KRT6B(2), KRT71(2), KRT72(2), KRT73(6), KRT75(1), KRT76(2), KRT77(3), KRT79(3), KRT81(3), KRT82(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), NES(11), PRPH(2), RELN(24), THBS1(1), THBS3(3), THBS4(1), TNC(11), TNXB(15), VIM(4), VWF(15) 63492600 440 149 440 126 114 153 95 32 46 0 0.0046 0.39 7 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 11 CASR(8), GABBR1(1), GPRC5A(1), GPRC5C(4), GRM1(10), GRM2(2), GRM4(1), GRM7(8), GRM8(8) 4577092 43 36 43 18 8 12 11 6 6 0 0.0049 0.39 8 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 19 F10(3), F11(3), F12(1), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), LPA(11), PLAT(1), PLAU(2), PLG(1), SERPINB2(3), SERPINF2(3), VWF(15) 9118406 79 59 79 17 12 31 22 6 8 0 0.0054 0.39 9 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(7), ADCY8(13), ARAF(3), BRAF(7), CACNA1C(12), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(12), EP300(6), GRIA1(6), GRIA2(3), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(10), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), RAP1B(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4) 26244498 186 110 185 56 56 53 34 22 21 0 0.0058 0.39 10 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3) 1875230 21 19 21 2 5 8 3 3 2 0 0.0069 0.39 11 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3) 1875230 21 19 21 2 5 8 3 3 2 0 0.0069 0.39 12 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(1), AKT3(2), BLNK(1), BTK(4), CARD11(3), CD19(2), CD22(5), CD81(1), CHP(2), CHUK(2), CR2(9), FCGR2B(2), FOS(1), HRAS(1), IKBKB(2), INPP5D(5), JUN(3), KRAS(1), LILRB3(3), LYN(1), MALT1(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), RAC1(1), RASGRP3(6), SYK(1), VAV1(7), VAV2(3), VAV3(1) 19679502 122 87 121 36 30 31 18 20 23 0 0.010 0.53 13 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(2) 537204 8 8 8 3 3 1 3 0 1 0 0.013 0.63 14 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 DLG4(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), NOS1(10), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), SYT1(3) 6076030 52 43 52 13 17 15 5 7 8 0 0.017 0.74 15 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(2), AGTR2(3), ATP8A1(5), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(3), FPR1(1), GALR1(3), GALT(1), GHSR(2), GPR77(3), GRPR(2), LHCGR(7), MC2R(2), MC3R(2), MC4R(1), MC5R(3), NMBR(2), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), TACR1(2), TACR3(3), TRHR(1), TSHR(1) 13470328 107 70 107 39 25 38 20 5 19 0 0.020 0.83 16 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(9), NRG2(2), NRG3(5), PRKCA(4), PSEN1(1) 2417774 21 21 21 6 3 8 3 2 5 0 0.023 0.90 17 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(7), ADRB2(3), GNAS(5), PLCE1(11), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 3962102 34 31 33 10 13 8 5 4 4 0 0.028 0.98 18 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(3), ACVR1C(3), AKT1(1), AKT3(2), ARRB1(2), ATF2(2), BDNF(1), BRAF(7), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CACNA2D1(8), CACNA2D2(3), CACNA2D3(1), CACNA2D4(6), CACNB2(2), CACNB3(2), CACNB4(1), CACNG3(2), CACNG4(2), CACNG6(1), CACNG7(4), CD14(1), CDC25B(1), CDC42(1), CHP(2), CHUK(2), DAXX(2), DUSP10(3), DUSP16(1), DUSP4(2), DUSP5(4), DUSP6(1), DUSP7(1), DUSP9(2), EGF(6), EGFR(6), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FLNA(8), FLNB(3), FLNC(11), FOS(1), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(1), IKBKB(2), IL1B(1), IL1R2(3), JUN(3), KRAS(1), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MAPT(4), MEF2C(3), MKNK2(1), MOS(4), MRAS(2), MYC(1), NFATC2(4), NFATC4(1), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NTF3(3), NTRK1(3), NTRK2(1), PAK1(1), PDGFB(1), PDGFRA(8), PDGFRB(4), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PPM1A(2), PPM1B(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTPN5(1), PTPRR(7), RAC1(1), RAF1(1), RAP1B(1), RAPGEF2(5), RASA1(5), RASA2(3), RASGRF1(5), RASGRF2(4), RASGRP1(1), RASGRP3(6), RASGRP4(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(4), RRAS2(2), SOS1(6), SOS2(5), SRF(2), STK3(2), STK4(2), TAOK1(6), TAOK2(5), TAOK3(3), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF1A(2), TRAF6(1) 77801130 477 153 472 136 107 169 89 46 66 0 0.029 0.98 19 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 9 EPX(4), GBA3(6), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TYR(3) 2183170 20 18 20 6 2 6 10 0 2 0 0.035 1.00 20 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(9), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5E(2) 3938428 37 30 37 6 7 16 7 4 3 0 0.047 1.00 21 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(3), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(2), STAT4(4), TYK2(5) 4886634 35 34 34 7 7 12 8 3 5 0 0.050 1.00 22 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(5), GNB1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4) 2534364 20 20 20 6 4 8 3 2 3 0 0.051 1.00 23 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNG(1), IFNGR1(3), IFNGR2(1), IKBKB(2), JAK2(3), LIN7A(2), NFKB1(2), RB1(7), RELA(2), TNFRSF1A(2), TNFRSF1B(1), USH1C(5), WT1(4) 4848186 35 31 35 5 6 8 10 3 8 0 0.054 1.00 24 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(12), EP300(6), LPL(3), NCOA1(5), NCOA2(9), RXRA(1) 4966378 36 33 35 14 6 14 7 3 6 0 0.055 1.00 25 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(5), SPCS1(1), SPCS3(2) 845144 9 8 9 1 0 2 2 1 4 0 0.057 1.00 26 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 184 ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), ARHGAP5(1), BCAR1(5), BIRC3(3), BRAF(7), CAPN2(2), CAV2(1), CAV3(1), CCND2(3), CCND3(1), CDC42(1), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COMP(1), CTNNB1(3), DIAPH1(1), DOCK1(3), EGF(6), EGFR(6), ERBB2(1), FARP2(6), FIGF(1), FLNA(8), FLNB(3), FLNC(11), FLT1(8), FN1(16), FYN(3), GRLF1(11), HGF(6), HRAS(1), IBSP(4), IGF1(3), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), JUN(3), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(3), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARVB(1), PARVG(1), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PDPK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(1), PRKCA(4), PRKCG(8), PTK2(4), PXN(3), RAC1(1), RAF1(1), RAP1B(1), RAPGEF1(3), RELN(24), ROCK1(5), ROCK2(3), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), THBS1(1), THBS3(3), THBS4(1), TLN1(3), TLN2(11), TNC(11), TNXB(15), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCL(2), VEGFC(4), VWF(15) 95801024 618 160 616 188 156 214 125 52 71 0 0.057 1.00 27 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 5 ARG1(2), ASL(3), GLS(2), GLUD1(4) 1178716 11 11 11 4 1 6 2 0 2 0 0.058 1.00 28 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), F10(3), F11(3), F12(1), F2R(2), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), SERPINC1(5), SERPING1(1) 12073384 89 63 89 21 16 38 20 5 10 0 0.061 1.00 29 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(5), CD2(1), CD33(2), CD5(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), ITGAX(9), TLR2(3), TLR7(3), TLR9(1) 4550748 35 32 34 10 9 14 6 2 4 0 0.063 1.00 30 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(3), BRAF(7), CD244(2), CHP(2), FAS(1), FASLG(1), FCGR3A(3), FCGR3B(2), FYN(3), GZMB(1), HLA-B(1), HLA-C(1), HLA-G(1), HRAS(1), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), ITGAL(1), ITGB2(3), KIR2DL1(1), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(1), KRAS(1), LCK(2), LCP2(2), MAP2K1(2), MAPK1(1), MAPK3(1), NCR1(5), NCR2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), PAK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRF1(1), PRKCA(4), PRKCG(8), PTPN11(2), RAC1(1), RAF1(1), SH2D1A(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), SYK(1), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP3(1), VAV1(7), VAV2(3), VAV3(1), ZAP70(2) 29957578 188 106 187 56 45 60 42 20 21 0 0.064 1.00 31 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(5), GREB1(12), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1) 3050208 24 24 24 10 9 7 6 1 1 0 0.069 1.00 32 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 162 ADCY1(7), ADCY3(4), ADCY4(3), ADCY7(4), ADCY8(13), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), AGTR1(2), ATP2A1(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(1), CD38(1), CHP(2), CHRM2(6), CHRM3(4), CHRM5(2), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(3), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), F2R(2), GNA14(1), GNAL(1), GNAS(5), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(10), GRPR(2), HRH1(3), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), LHCGR(7), LTB4R2(1), MYLK(5), MYLK2(2), NOS1(10), NOS3(1), NTSR1(3), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDGFRA(8), PDGFRB(4), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PLN(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(2), RYR1(24), SLC8A3(3), SPHK2(1), TACR1(2), TACR3(3), TBXA2R(2), TNNC1(1), TRHR(1), TRPC1(4), VDAC1(1) 67460398 463 152 461 135 133 151 81 47 51 0 0.071 1.00 33 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), CNR2(2), DNMT1(3), MTNR1A(1), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), TBXA2R(2) 2971888 25 24 25 8 9 9 6 0 1 0 0.073 1.00 34 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 23 ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(8), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GLS(2), GLUD1(4), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSS(2), NADSYN1(6), PPAT(2) 8058416 59 49 59 15 10 27 14 4 4 0 0.074 1.00 35 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(1), AKT3(2), BTK(4), FCER1A(2), FYN(3), HRAS(1), IL4(2), INPP5D(5), KRAS(1), LCP2(2), LYN(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCG1(1), PLCG2(3), PRKCA(4), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7), VAV2(3), VAV3(1) 18967146 119 84 119 30 28 37 23 13 18 0 0.075 1.00 36 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(2), AGTR2(3), CMA1(2), COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6) 6924734 45 41 45 14 10 22 7 0 6 0 0.082 1.00 37 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(7), ADRB2(3), CFTR(5), GNAS(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 3468864 28 25 28 8 9 7 6 3 3 0 0.086 1.00 38 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(7), GNAS(5), GNB1(1), PRKAR1A(2) 1804742 15 15 15 5 4 5 3 2 1 0 0.091 1.00 39 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), JAK2(3), STAT4(4), TYK2(5) 3830026 26 25 26 7 4 7 7 2 6 0 0.093 1.00 40 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 32 ALDH4A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), DAO(1), EPRS(10), GATM(1), GLUD1(4), GOT2(2), LAP3(1), NOS1(10), NOS3(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), PARS2(2), RARS(4), RARS2(2) 8582448 59 50 59 15 10 24 13 2 10 0 0.097 1.00 41 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX1(2), ACOX3(4), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5) 2684774 23 21 23 3 5 6 6 3 3 0 0.097 1.00 42 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(9), BST1(1), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT12(2) 5841960 48 38 48 10 10 20 9 4 5 0 0.097 1.00 43 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 35 ACTA1(1), ACTN2(6), ACTN3(2), ACTN4(4), DES(2), DMD(21), FAM48A(1), MYBPC1(8), MYBPC3(3), MYH3(4), MYH6(11), MYH7(8), MYL1(3), MYL2(1), MYL3(2), MYOM1(9), NEB(20), TNNI2(1), TNNI3(1), TNNT1(1), TNNT2(2), TNNT3(3), TPM3(1), VIM(4) 16816728 119 77 119 47 34 33 25 10 17 0 0.10 1.00 44 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(2), CCR1(2), CCR3(1), CCR4(3), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1), TGFB1(1), TGFB2(2) 5101124 37 32 37 13 8 12 9 0 8 0 0.10 1.00 45 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(1), AKT3(2), BRAF(7), CAB39(1), DDIT4(2), EIF4B(4), FIGF(1), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(3), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), STK11(3), TSC1(5), TSC2(5), ULK1(1), ULK2(2), VEGFC(4) 14056126 85 67 84 23 15 25 22 8 15 0 0.11 1.00 46 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 DNM1(1), GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), GPHN(1), NSF(2), UBQLN1(1) 2732656 22 20 22 6 6 10 4 0 2 0 0.11 1.00 47 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(6), EGFR(6), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(13), RAF1(1), RASA1(5), SHC1(1), SOS1(6) 6589916 44 39 43 7 11 13 8 3 9 0 0.11 1.00 48 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(3), EGF(6), EGFR(6), FOS(1), HRAS(1), JUN(3), MYC(1), NFKB1(2), PLCG1(1), PRKCA(4), RELA(2) 5560898 40 34 38 11 8 13 7 4 8 0 0.12 1.00 49 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 29 ABAT(2), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(8), EARS2(2), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GFPT2(1), GLS(2), GLUD1(4), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSR(2), GSS(2), NADSYN1(6), PPAT(2) 9483306 65 53 65 19 10 30 15 6 4 0 0.13 1.00 50 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(7), AKT1(1), CAMK2B(2), CAMK2D(1), CREB1(1), GNAS(5), HRAS(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(6) 7232318 47 41 47 10 11 11 14 6 5 0 0.13 1.00 51 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 6 EPX(4), GBA3(6), LPO(2), MPO(3), PRDX6(1) 1850310 16 14 16 5 2 4 9 0 1 0 0.13 1.00 52 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 7 CPN2(1), CYP11A1(2), CYP17A1(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3) 1585268 15 13 15 4 3 7 3 1 1 0 0.13 1.00 53 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), DRD1(1), DRD2(2), EGF(6), EGFR(6), GJA1(4), GJD2(2), GNAI1(2), GNAI3(1), GNAS(5), GRM1(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(2), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(2), NPR2(2), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(1), RAF1(1), SOS1(6), SOS2(5), TJP1(8), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1) 34514378 223 116 222 60 62 68 45 22 26 0 0.13 1.00 54 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(3), BRAF(7), C7orf16(1), CACNA1A(7), CRHR1(2), GNA12(1), GNAI1(2), GNAI3(1), GNAS(5), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(8), GRID2(12), GRM1(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1(3), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), LYN(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOS1(10), NOS3(1), NPR1(2), NPR2(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(1), RYR1(24) 29281178 216 105 216 61 51 75 43 19 28 0 0.14 1.00 55 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), KARS(2) 1862592 15 15 15 5 2 5 4 2 2 0 0.15 1.00 56 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(5), FYN(3), LRP8(1), RELN(24) 3755444 34 25 34 9 7 9 10 7 1 0 0.15 1.00 57 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(12), DFFB(2), GZMA(4), GZMB(1), PRF1(1) 2860104 21 20 21 9 6 6 3 2 4 0 0.15 1.00 58 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 81 AGRN(1), CD36(1), CD44(3), CD47(2), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), DAG1(1), FN1(16), FNDC1(7), FNDC3A(1), GP1BA(2), GP5(3), GP6(2), GP9(1), HMMR(1), HSPG2(7), IBSP(4), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), RELN(24), SDC1(1), SDC2(2), SDC3(1), SV2A(2), SV2B(4), SV2C(3), THBS1(1), THBS3(3), THBS4(1), TNC(11), TNXB(15), VWF(15) 57982788 380 140 380 111 99 137 80 21 43 0 0.16 1.00 59 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(2), GLS(2), GLUD1(4) 1445894 11 11 11 5 1 7 2 0 1 0 0.17 1.00 60 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ADCY3(4), ADCY9(3), ARF1(1), ARF5(3), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(1), PLCG2(3), PRKCA(4), SEC61A1(2), SEC61A2(1), TRIM23(2) 9803528 55 49 55 16 12 15 17 5 6 0 0.18 1.00 61 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), DRD1(1), DRD2(2), GRM1(10), PLCB1(6), PPP1R1B(1), PPP3CA(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 4232840 31 27 31 8 10 11 4 3 3 0 0.20 1.00 62 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2) 6185678 44 37 44 18 11 17 5 5 6 0 0.20 1.00 63 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2) 6185678 44 37 44 18 11 17 5 5 6 0 0.20 1.00 64 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(3) 1352088 11 10 11 0 0 4 4 1 2 0 0.20 1.00 65 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(3), EGF(6), EGFR(6), MET(3), PDGFRA(8), PRKCA(4), SH3GLB1(1), SH3KBP1(4) 5214866 36 32 35 6 10 12 6 3 5 0 0.20 1.00 66 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(7), CREM(2), FSHB(1), GNAS(5), XPO1(2) 2218948 17 16 17 8 5 4 3 4 1 0 0.20 1.00 67 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 435032 4 4 4 1 1 1 2 0 0 0 0.21 1.00 68 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(1), AKR1D1(4), ARSD(1), ARSE(2), CARM1(1), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(1), HSD17B7(1), HSD3B1(4), HSD3B2(3), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), WBSCR22(3) 12450566 88 63 88 13 26 25 20 8 9 0 0.21 1.00 69 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(3), NR0B2(1), NR1H3(2), NR1H4(2), RXRA(1) 1464406 10 10 10 3 2 3 2 1 2 0 0.21 1.00 70 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 79 ANPEP(5), CD14(1), CD19(2), CD1A(4), CD1C(5), CD1D(3), CD1E(4), CD2(1), CD22(5), CD33(2), CD34(2), CD36(1), CD37(2), CD38(1), CD3D(1), CD4(1), CD44(3), CD5(2), CD8B(1), CD9(1), CR1(4), CR2(9), CSF1(2), CSF1R(3), CSF3R(5), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(4), GP1BA(2), GP5(3), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(1), IL1R2(3), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(3), KIT(5), MME(8), MS4A1(2), TFRC(2) 21244300 142 89 142 60 35 61 25 4 17 0 0.21 1.00 71 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(9), PDXP(1), PSAT1(1) 1306342 11 10 11 2 1 4 2 3 1 0 0.22 1.00 72 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(4), CR2(9), FCGR2B(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3) 4122124 28 26 28 13 7 9 4 5 3 0 0.22 1.00 73 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 28 AKR1C4(1), AKR1D1(4), ARSB(1), ARSD(1), ARSE(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4) 6510528 47 37 47 7 11 14 12 4 6 0 0.23 1.00 74 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), FOS(1), HRAS(1), INSR(7), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SLC2A4(2), SOS1(6), SRF(2) 6296750 42 36 41 7 10 13 8 5 6 0 0.24 1.00 75 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 133 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), ANXA6(4), ARRB1(2), ATP1A4(3), ATP1B2(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1S(5), CACNB3(2), CALR(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(4), GJB2(1), GJB4(1), GNAI3(1), GNAZ(2), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), ITPR1(4), ITPR2(11), ITPR3(1), KCNB1(1), KCNJ5(2), MIB1(2), NME7(2), PEA15(1), PLCB3(3), PLN(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS9(2), RYR1(24), SFN(2), SLC8A3(3), USP5(1), YWHAB(1), YWHAQ(1) 44979888 275 119 274 84 71 105 44 23 32 0 0.24 1.00 76 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 134924 1 1 1 0 0 0 1 0 0 0 0.25 1.00 77 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(1), PIK3R1(1), PLCB1(6), PLCG1(1), PRKCA(4), VAV1(7) 2863130 20 19 20 5 7 5 3 4 1 0 0.25 1.00 78 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(1), FOS(1), JUN(3), MAPK1(1), MAPK14(1), MAPK8(2), PRKCA(4) 1727846 13 13 12 2 5 3 3 1 1 0 0.25 1.00 79 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(12), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2) 2728562 18 18 18 5 4 8 3 2 1 0 0.25 1.00 80 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(3), CREBBP(12), EP300(6), MAP2K1(2), MAP3K7(2), MAPK3(1), TGFB1(1), TGFB2(2), TGFBR2(3) 6897500 41 38 40 11 6 16 10 3 6 0 0.26 1.00 81 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BUB1(3), CDKL2(2), CDS1(2), CLK1(1), CLK2(1), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), MOS(4), NEK1(3), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CB(2), PIK3CG(9), PIM2(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3), PLK3(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), PRKG1(4), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KB1(1), STK11(3), VRK1(1) 30579510 188 102 187 47 54 55 38 15 26 0 0.26 1.00 82 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CKS1B(1), CUL1(2), E2F1(2), RB1(7), RBX1(1), SKP2(1), UBE2M(1) 2348354 15 14 15 1 2 6 0 1 6 0 0.26 1.00 83 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1) 3417422 22 20 22 8 3 7 6 0 6 0 0.27 1.00 84 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(2), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(3), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(12), DPYSL2(1), DPYSL5(6), EFNA3(1), EFNB1(2), EFNB2(1), EPHA1(3), EPHA2(1), EPHA3(6), EPHA4(1), EPHA6(9), EPHA7(7), EPHA8(4), EPHB2(4), EPHB3(6), EPHB4(2), EPHB6(3), FYN(3), GNAI1(2), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(2), LIMK2(2), MAPK1(1), MAPK3(1), MET(3), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NGEF(1), NRP1(5), NTN1(2), NTN4(1), NTNG1(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLXNA1(6), PLXNA2(2), PLXNA3(3), PLXNB1(3), PLXNB3(3), PLXNC1(8), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PTK2(4), RAC1(1), RASA1(5), RGS3(4), ROBO1(6), ROBO2(6), ROBO3(4), ROCK1(5), ROCK2(3), SEMA3A(3), SEMA3B(1), SEMA3C(5), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(5), SEMA5A(7), SEMA5B(4), SEMA6C(5), SEMA6D(6), SEMA7A(1), SLIT1(4), SLIT2(10), SLIT3(8), SRGAP1(2), SRGAP2(4), SRGAP3(3), UNC5B(2), UNC5C(6) 52273082 304 130 304 118 64 105 62 28 45 0 0.27 1.00 85 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(6), PLCB2(5), PRL(1), VIP(1) 3042376 23 21 23 8 10 7 3 2 1 0 0.27 1.00 86 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(1), GSTZ1(2) 353152 3 3 3 1 1 0 0 1 1 0 0.27 1.00 87 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(5), P2RY1(2), P2RY2(1), P2RY6(1) 1601110 12 11 12 4 5 5 1 0 1 0 0.27 1.00 88 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C9(1), MASP1(9), MASP2(1), MBL2(3) 5353528 37 31 37 13 7 15 9 3 3 0 0.28 1.00 89 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(7), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), KIT(5), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 5036332 32 30 32 6 9 13 4 3 3 0 0.28 1.00 90 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 26 ACTA1(1), AKT1(1), BDKRB2(2), CHRNA1(1), FLT1(8), FLT4(3), NOS3(1), PDE2A(2), PDE3A(4), PDE3B(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), SLC7A1(4), SYT1(3) 7779846 48 41 48 26 12 13 9 7 7 0 0.28 1.00 91 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(2) 1077612 8 8 8 3 0 3 2 1 2 0 0.28 1.00 92 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(5), ABAT(2), ACY3(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), NARS2(2), PC(2), PDHA1(2), PDHA2(5) 10270600 66 53 66 21 13 29 11 6 7 0 0.28 1.00 93 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 133 ACTA1(1), ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ARRB1(2), ATF2(2), ATP2A2(3), ATP2A3(2), CACNB3(2), CAMK2B(2), CAMK2D(1), CNN1(2), CORIN(8), CREB3(2), CRHR1(2), DGKZ(3), FOS(1), GABPA(2), GABPB2(1), GJA1(4), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), GSTO1(1), GUCY1A3(5), IGFBP3(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), MIB1(2), MYL2(1), MYLK2(2), NFKB1(2), NOS1(10), NOS3(1), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(3), PLCG1(1), PLCG2(3), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCQ(4), PRKD1(9), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS9(2), RYR1(24), SFN(2), SP1(1), TNXB(15), USP5(1), YWHAB(1), YWHAQ(1) 41029356 241 116 239 73 69 88 40 15 29 0 0.29 1.00 94 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CUL1(2), E2F1(2), RB1(7) 1838028 11 11 11 1 0 6 0 0 5 0 0.29 1.00 95 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 28 B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GCNT1(2), GCNT3(2), OGT(2), ST3GAL1(1), ST6GALNAC1(3) 8069986 47 44 46 13 8 19 14 3 3 0 0.29 1.00 96 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2) 6739792 43 39 43 9 10 12 15 3 3 0 0.30 1.00 97 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), CREBBP(12), CTNNB1(3), DVL1(3), EP300(6), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(11) 8810288 53 46 52 12 9 16 17 3 8 0 0.30 1.00 98 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 3 GLS(2), GLUD1(4) 848170 6 6 6 2 1 3 1 0 1 0 0.30 1.00 99 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT2(2), TAT(1), TYR(3) 1255434 8 8 8 2 2 4 0 1 1 0 0.30 1.00 100 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(1), IL12A(1), IL12B(2) 802958 5 5 5 1 0 1 2 0 2 0 0.30 1.00 101 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(4), HDC(3), PNMT(2), TH(1), TPH1(1) 1656468 12 11 12 2 2 6 2 1 1 0 0.31 1.00 102 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), RB1(7), SP1(1), SP3(1) 1794596 10 10 10 1 1 3 0 0 6 0 0.31 1.00 103 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(6), KARS(2) 1265758 10 10 10 3 2 4 3 0 1 0 0.32 1.00 104 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), DAO(1), GATM(1), GLUD1(4), GOT2(2), NOS1(10), NOS3(1), ODC1(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), RARS(4), SMS(2) 11077830 64 55 64 19 14 25 11 4 10 0 0.32 1.00 105 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(6), HRAS(1), ITGA1(3), ITGB1(3), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(4), PXN(3), TLN1(3) 8846956 52 46 51 13 15 16 7 7 7 0 0.33 1.00 106 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA4(1), ANXA5(2), ANXA6(4), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(3), HSD11B2(1), PLA2G4A(5), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGS1(2), TBXAS1(2) 5652568 39 33 39 15 8 14 8 3 6 0 0.33 1.00 107 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(7), AP2A1(2), AP2M1(1), DNM1(1), EPN1(2), EPS15(4), PICALM(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(3) 6051110 37 34 37 9 11 8 6 5 7 0 0.33 1.00 108 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(2) 579390 4 4 4 0 1 1 1 1 0 0 0.34 1.00 109 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(2), GNAS(5), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(6), PLCB1(6), PPP1R12B(4), PRKCA(4), PTK2(4), RAF1(1), ROCK2(3) 6923488 45 39 45 14 12 18 8 3 4 0 0.35 1.00 110 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 192952 1 1 1 0 0 0 0 0 1 0 0.35 1.00 111 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(7), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(1), DUSP9(2), EEF2K(3), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), SHC1(1), SOS1(6), SOS2(5), TRAF3(1) 8109146 51 42 50 11 8 13 17 3 10 0 0.35 1.00 112 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), CREBBP(12), CSNK1A1(2), CSNK2A1(2), CTBP1(1), CTNNB1(3), DVL1(3), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(1), TLE1(4), WIF1(3) 7875610 48 41 48 10 11 14 11 5 7 0 0.35 1.00 113 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 17 CALCR(5), CALCRL(3), CRHR1(2), CRHR2(2), EMR1(9), EMR2(4), GHRHR(3), GLP1R(1), GLP2R(3), GPR64(3), LPHN1(1), LPHN2(6) 6101662 42 34 42 16 11 12 10 4 5 0 0.35 1.00 114 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(12), EP300(6), ESR1(5), MAPK1(1), MAPK3(1) 4039354 25 24 24 6 5 9 6 2 3 0 0.36 1.00 115 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(7), GNAS(5), GNB1(1), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 4084922 28 24 28 7 8 9 5 3 3 0 0.36 1.00 116 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3) 1036850 7 7 7 3 2 2 3 0 0 0 0.37 1.00 117 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT3(3), FUT5(4), FUT6(2) 1397656 9 8 9 2 2 3 3 1 0 0 0.37 1.00 118 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), GPI(5), HK1(3), PFKL(2), PGK1(1), PKLR(3), TPI1(3) 2381818 19 15 19 4 6 5 5 0 3 0 0.37 1.00 119 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(6), ERBB3(3), NRG1(3), UBE2D1(1) 2762204 19 17 18 4 6 6 3 1 3 0 0.38 1.00 120 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C8B(2), C9(1), MASP1(9) 5207568 35 29 35 15 8 13 9 3 2 0 0.38 1.00 121 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3) 455858 3 3 3 0 0 2 1 0 0 0 0.39 1.00 122 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(7), CAP1(2), CCNB1(1), CDC25C(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), MAPK1(1), MAPK3(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(2) 5515508 33 30 33 12 7 11 7 6 2 0 0.39 1.00 123 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL16(5), IL4(2), LTA(2) 2643656 16 16 16 4 3 4 5 3 1 0 0.39 1.00 124 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRA(2), CP(2), CPOX(2), EARS2(2), EPRS(10), FECH(2), FTH1(2), FTMT(4), GUSB(2), MMAB(1), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UROD(1) 10816526 66 54 66 14 14 22 19 5 6 0 0.39 1.00 125 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 20 ASNS(3), CA12(2), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(4), GLUL(2) 4193680 24 24 24 2 6 9 6 1 2 0 0.40 1.00 126 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(3), PIK3R4(5), PRKAA2(3), ULK1(1), ULK2(2) 5718962 34 30 33 9 10 8 12 1 3 0 0.41 1.00 127 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(1) 506410 3 3 3 0 0 1 1 1 0 0 0.41 1.00 128 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(5), AMY2B(3), ENPP1(7), ENPP3(3), G6PC(2), GANAB(5), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), MGAM(3), PYGB(3), PYGM(4), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UXS1(3) 14193898 89 63 89 25 22 32 21 6 8 0 0.41 1.00 129 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(4), BDKRB1(1), BDKRB2(2), C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C3AR1(1), C4BPA(1), C5(1), C5AR1(1), C7(7), C8A(3), C8B(2), C9(1), CD46(2), CFB(1), CFH(4), CFI(2), CPB2(2), CR1(4), CR2(9), F10(3), F11(3), F12(1), F13A1(3), F2R(2), F3(1), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), KNG1(4), MASP1(9), MASP2(1), MBL2(3), PLAT(1), PLAU(2), PLG(1), SERPINA1(1), SERPINA5(1), SERPINC1(5), SERPIND1(1), SERPINF2(3), SERPING1(1), VWF(15) 23717254 161 90 161 54 34 55 41 16 15 0 0.41 1.00 130 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(2), AGTR2(3), BDKRB2(2), KNG1(4), NOS3(1) 2766476 17 16 17 10 3 6 4 2 2 0 0.42 1.00 131 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(4), NAT2(1), XDH(8) 2131550 15 13 15 6 4 6 2 1 2 0 0.42 1.00 132 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1) 13876346 79 60 79 16 16 27 17 9 10 0 0.42 1.00 133 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1) 13876346 79 60 79 16 16 27 17 9 10 0 0.42 1.00 134 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 8 CYP17A1(1), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(4), HSD3B2(3) 1825212 11 11 11 2 3 3 2 2 1 0 0.42 1.00 135 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(1), HRAS(1), KLK2(1), NTRK1(3), PIK3R1(1), PLCG1(1), PRKCA(4), SHC1(1), SOS1(6) 3626928 19 19 19 5 3 5 6 2 3 0 0.42 1.00 136 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(2), F13A1(3), F2R(2), FGA(5), FGB(3), FGG(1), PLAT(1), PLAU(2), PLG(1), SERPINB2(3) 3573172 23 21 23 7 3 10 8 0 2 0 0.42 1.00 137 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(2), BCAR1(5), BDKRB1(1), BDKRB2(2), BRAF(7), CD14(1), CDC42(1), CFL1(2), CFL2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CYFIP1(4), CYFIP2(6), DIAPH1(1), DIAPH2(1), DIAPH3(5), DOCK1(3), EGF(6), EGFR(6), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FN1(16), GIT1(1), GNA12(1), GNG12(1), GRLF1(11), GSN(2), HRAS(1), IQGAP1(6), IQGAP2(6), IQGAP3(9), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), KRAS(1), LIMK2(2), MAP2K1(2), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(3), MYH10(1), MYH14(4), MYH9(12), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), NCKAP1(4), NCKAP1L(8), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDGFB(1), PDGFRA(8), PDGFRB(4), PFN2(1), PFN3(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PPP1R12B(4), PTK2(4), PXN(3), RAC1(1), RAF1(1), RDX(1), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(6), SOS2(5), SSH1(1), SSH2(6), TIAM1(8), TIAM2(3), VAV1(7), VAV2(3), VAV3(1), VCL(2), WAS(4), WASL(2) 75493894 458 146 456 135 92 160 96 48 62 0 0.42 1.00 138 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR109B(2), GPR161(1), GPR171(2), GPR18(1), GPR34(1), GPR39(1), GPR45(4), GPR65(1), GPR68(1), GPR75(2) 2642232 19 16 19 6 7 7 4 0 1 0 0.43 1.00 139 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), GOT2(2), LDHB(2), LDHC(1) 1840164 10 10 10 2 0 3 3 2 2 0 0.43 1.00 140 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(12), EP300(6), NCOA3(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(1), RXRA(1) 5467804 34 29 33 10 7 14 4 5 4 0 0.44 1.00 141 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2R(2), F3(1), F5(14), FGA(5), FGB(3), FGG(1), SERPINC1(5) 4394464 34 25 34 7 3 13 13 3 2 0 0.44 1.00 142 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 22 ASNS(3), CA12(2), CA13(1), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(4), GLUL(2) 4508384 25 25 25 2 6 10 6 1 2 0 0.44 1.00 143 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(1), GAD1(4), GAD2(5), GGT1(1) 1577970 13 10 13 8 4 6 2 1 0 0 0.44 1.00 144 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(1), EPHA4(1), FYN(3), ITGA1(3), ITGB1(3), L1CAM(2), LYN(1), RAP1B(1), SELP(8) 3687448 23 21 23 12 6 3 6 1 7 0 0.44 1.00 145 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(1), BLNK(1), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(8), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(1), SOS1(6), SYK(1), VAV1(7), VAV2(3), VAV3(1) 8747988 50 44 49 10 10 14 16 6 4 0 0.45 1.00 146 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(7), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(4) 3132622 19 18 19 6 5 3 8 0 3 0 0.45 1.00 147 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 123 ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CGN(4), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CSDA(2), CSNK2A1(2), CTNNB1(3), CTTN(2), EPB41(2), EPB41L1(1), EPB41L2(1), EXOC3(2), EXOC4(2), F11R(1), GNAI1(2), GNAI3(1), HCLS1(3), HRAS(1), IGSF5(2), INADL(9), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(5), MAGI2(7), MAGI3(1), MLLT4(1), MPDZ(4), MPP5(2), MRAS(2), MYH1(13), MYH10(1), MYH11(7), MYH13(8), MYH14(4), MYH15(10), MYH3(4), MYH6(11), MYH7(8), MYH7B(4), MYH9(12), MYL2(1), MYLPF(1), PARD3(5), PARD6A(1), PPM1J(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(2), PPP2R4(1), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), RAB3B(1), RRAS2(2), SPTAN1(2), SYMPK(6), TJAP1(4), TJP1(8), TJP2(3), TJP3(1), VAPA(1), YES1(1) 47822014 274 127 274 84 68 80 61 29 36 0 0.45 1.00 148 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(3), ACVR1C(3), ACVR2A(3), ACVRL1(3), AMHR2(4), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), COMP(1), CREBBP(12), CUL1(2), DCN(1), EP300(6), GDF5(4), GDF6(2), ID2(1), ID4(1), IFNG(1), INHBA(4), INHBC(1), LEFTY2(2), LTBP1(10), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(5), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), SKP1(1), SMAD1(3), SMAD2(1), SMAD4(2), SMAD7(2), SMURF1(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR2(3), THBS1(1), THBS3(3), THBS4(1), ZFYVE16(3), ZFYVE9(5) 26483908 146 94 145 39 26 48 35 17 20 0 0.45 1.00 149 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(5), CHIT1(4), CMAS(2), CTBS(4), CYB5R1(1), GFPT2(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(1), MTMR6(4), UAP1(1) 7756350 47 38 47 13 11 16 9 3 8 0 0.45 1.00 150 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), SLC23A1(1), SLC23A2(2), SLC2A3(2) 6862612 39 35 39 10 12 17 4 1 5 0 0.45 1.00 151 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), TYR(3) 2593104 16 15 16 5 3 9 2 0 2 0 0.46 1.00 152 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(12), DAXX(2), HRAS(1), PAX3(2), RARA(1), RB1(7), SP100(1), TNFRSF1A(2), TNFRSF1B(1) 5006962 29 24 29 10 6 9 2 4 8 0 0.46 1.00 153 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), MTMR6(4), NFS1(2), TPK1(3) 1721082 11 11 11 1 1 4 5 0 1 0 0.47 1.00 154 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 106 ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ARHGAP5(1), BCAR1(5), CDC42(1), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNB1(3), CTNND1(3), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(2), GNAI3(1), GRLF1(11), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), ITK(2), MAPK13(2), MAPK14(1), MLLT4(1), MMP2(3), MMP9(4), MSN(3), MYL2(1), MYLPF(1), NCF2(2), NCF4(1), NOX1(2), NOX3(5), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), PTPN11(2), PXN(3), RAC1(1), RAP1B(1), RAPGEF4(5), RASSF5(1), RHOH(3), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCAM1(4), VCL(2) 32719960 211 106 211 70 52 70 45 22 22 0 0.47 1.00 155 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP6(2), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(4), TYR(3) 4031522 24 22 24 7 4 10 5 0 5 0 0.47 1.00 156 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(7), AKT1(1), GNAI1(2), GNB1(1), ITGAV(3), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(8), PIK3R1(1), PLCB1(6), PRKCA(4), PTK2(4), RAC1(1), SMPD1(3), SMPD2(1) 6767204 47 36 47 13 15 16 9 6 1 0 0.47 1.00 157 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(6), PRKCA(4), RAF1(1), RELA(2) 4191188 27 23 26 7 9 7 3 6 2 0 0.47 1.00 158 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT3(2), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(1), INPP5D(5), JAK1(1), JAK2(3), JAK3(7), NR0B2(1), PI3(1), PPP1R13B(4), RPS6KB1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), STAT6(1), TYK2(5) 9476898 57 45 57 11 5 21 17 4 10 0 0.47 1.00 159 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(2), NFKB1(2), NOX1(2), RELA(2), XDH(8) 2705600 18 14 18 2 4 5 2 4 3 0 0.47 1.00 160 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 50 ALG6(2), CCKBR(1), CCR3(1), CELSR1(9), CELSR2(5), CELSR3(9), CHRM2(6), CHRM3(4), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(3), F2R(2), GHRHR(3), GPR116(5), GPR132(1), GPR133(1), GPR143(2), GPR17(3), GPR18(1), GPR55(1), GPR56(1), GPR61(2), GPR77(3), GRM1(10), GRPR(2), HRH4(3), LGR6(2), LPHN2(6), LTB4R2(1), NTSR1(3), OR8G2(1), P2RY13(1), PTGFR(2), SMO(1), SSTR2(2), TAAR5(5), TSHR(1), VN1R1(2) 17100282 114 73 114 44 31 38 25 7 13 0 0.47 1.00 161 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), FOS(1), HRAS(1), IGF1(3), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2) 6085998 36 32 35 5 9 11 7 4 5 0 0.48 1.00 162 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(1), UGDH(2), UXS1(3) 1073162 7 6 7 0 0 3 2 1 1 0 0.48 1.00 163 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ABP1(4), ACADL(2), ACADM(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), MLYCD(1), SDS(2), SMS(2) 7843214 51 40 51 17 14 20 8 5 4 0 0.49 1.00 164 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), AOC3(3), CES1(2) 1611612 10 9 10 5 4 2 2 2 0 0 0.49 1.00 165 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(2), ACAT1(1), HADHA(2) 1468678 8 8 8 1 2 2 1 1 2 0 0.49 1.00 166 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6) 2875946 16 16 16 7 0 7 6 0 3 0 0.49 1.00 167 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ABP1(4), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), HIBCH(1), MLYCD(1), SMS(2) 7313308 47 37 47 16 15 17 6 5 4 0 0.50 1.00 168 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(2), MMP2(3), MMP9(4), RECK(3), TIMP2(1) 2030980 14 11 14 3 2 6 3 2 1 0 0.50 1.00 169 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 22 ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME3(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), RPIA(1), TKT(1), TPI1(3) 4972608 27 26 27 15 5 8 7 3 4 0 0.51 1.00 170 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(5), DARS(1), EPRS(10), FARS2(1), HARS(2), IARS(3), KARS(2), LARS2(3), MARS(1), NARS(2), RARS(4), SARS(2), TARS(3), WARS(3), WARS2(1), YARS(1) 8565716 45 42 45 12 6 15 17 2 5 0 0.51 1.00 171 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), CHAT(2), DBH(1), DDC(2), GAD1(4), GAD2(5), HDC(3), PAH(1), PNMT(2), TH(1), TPH1(1) 3978300 24 22 24 9 8 10 4 1 1 0 0.51 1.00 172 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(1), AKT1(1), AKT3(2), BTK(4), GSK3A(3), IARS(3), INPP5D(5), PDK1(1), PPP1R13B(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SOS1(6), SOS2(5), TEC(2), YWHAB(1), YWHAQ(1) 8850516 49 41 49 8 6 14 14 3 12 0 0.52 1.00 173 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3D(1), CD80(2), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(2), PIK3R1(1), PTPN11(2) 2833226 15 15 15 7 2 6 3 2 2 0 0.52 1.00 174 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(1), EIF4A1(4), EIF4A2(2), EIF4B(4), EIF4G1(6), EIF4G2(2), EIF4G3(3), PDK2(1), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5) 6686392 37 32 37 9 3 14 9 4 7 0 0.52 1.00 175 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(2), LDLR(3), LPL(3) 1424534 9 9 9 2 5 3 1 0 0 0 0.52 1.00 176 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), OCRL(5), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CB(2), PIK3CG(9), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3) 11733582 76 52 76 23 24 17 17 6 12 0 0.52 1.00 177 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(11), RANGAP1(4) 2248318 15 13 15 5 2 6 3 2 2 0 0.52 1.00 178 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(2), CHKA(2), PDHA1(2), PDHA2(5) 1926672 13 12 13 2 3 6 3 1 0 0 0.52 1.00 179 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(1), GOT2(2), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3) 11286268 73 54 73 25 19 28 13 6 7 0 0.52 1.00 180 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(2) 4317924 21 20 21 7 5 3 7 1 5 0 0.52 1.00 181 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(1), HDAC5(1), HRAS(1), JUN(3), NCOR2(6), RBL1(5), RBL2(5), SIN3A(5), SIN3B(3) 7269342 41 36 40 9 7 15 8 7 4 0 0.53 1.00 182 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(1), BCAR1(5), ILK(1), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(1), PIK3R1(1), PTK2(4), SHC1(1), SOS1(6) 4492542 26 23 26 5 8 7 7 2 2 0 0.53 1.00 183 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 41 ABCA1(5), ABCA10(8), ABCA12(7), ABCA13(25), ABCA2(6), ABCA3(3), ABCA4(10), ABCA5(4), ABCA6(6), ABCA7(3), ABCA8(5), ABCA9(9), ABCB10(4), ABCB11(5), ABCB4(6), ABCB5(6), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(4), ABCC10(5), ABCC11(3), ABCC2(4), ABCC3(1), ABCC4(1), ABCC5(4), ABCC6(1), ABCC8(5), ABCC9(9), ABCD1(3), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(4), CFTR(5), TAP1(2) 30600336 177 104 177 69 39 65 40 12 21 0 0.54 1.00 184 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MYC(1), SP1(1), SP3(1), WT1(4) 1666614 9 9 9 4 2 1 4 2 0 0 0.54 1.00 185 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(7), CPEB1(1), EGFR(6), ERBB2(1), ERBB4(9), ETS1(2), ETV6(4), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PIWIL1(5), PIWIL2(3), PIWIL3(3), RAF1(1), SOS1(6), SOS2(5), SPIRE1(1) 13594750 82 61 81 25 17 32 13 6 14 0 0.54 1.00 186 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(2), CPOX(2), EPRS(10), FECH(2), GUSB(2), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UROD(1) 7022990 38 35 38 9 6 14 13 2 3 0 0.55 1.00 187 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(4), GLI3(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(2) 4465486 25 23 25 12 4 11 4 3 3 0 0.55 1.00 188 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(1), CHUK(2), DAXX(2), EGF(6), EGFR(6), ETS1(2), FOS(1), HOXA7(2), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), RAF1(1), RELA(2), SP1(1), TNFRSF1A(2), TNFRSF1B(1) 13433838 77 60 75 17 23 24 14 6 10 0 0.55 1.00 189 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(2), IL5RA(2) 1438952 9 8 9 2 1 4 1 0 3 0 0.55 1.00 190 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PDGFRA(8), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2) 8769348 49 42 48 11 16 11 11 5 6 0 0.56 1.00 191 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(5), IL4(2), MAF(1), MAP2K3(2), MAPK14(1), NFATC2(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 3260782 23 19 23 6 10 7 3 1 2 0 0.56 1.00 192 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(1), CDK7(1), CHEK1(4), NEK1(3), WEE1(2) 1979716 11 11 11 1 3 5 2 0 1 0 0.56 1.00 193 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(6), GGT1(1) 1181208 7 6 7 4 1 2 3 0 1 0 0.56 1.00 194 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 ALCAM(3), CADM1(2), CADM3(3), CD2(1), CD22(5), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD40LG(2), CD58(1), CD6(1), CD80(2), CD86(1), CD8B(1), CDH1(3), CDH2(9), CDH3(1), CDH4(6), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(9), CNTN2(1), CNTNAP1(3), ESAM(4), F11R(1), GLG1(3), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(3), ITGA6(3), ITGA8(8), ITGAL(1), ITGAM(3), ITGAV(3), ITGB1(3), ITGB2(3), ITGB7(1), ITGB8(3), L1CAM(2), MADCAM1(1), MAG(4), NCAM1(2), NCAM2(10), NEGR1(2), NEO1(3), NFASC(5), NLGN1(7), NLGN2(1), NLGN3(4), NRCAM(3), NRXN2(7), NRXN3(7), PTPRC(3), PTPRF(6), PTPRM(6), PVRL1(2), PVRL3(2), SDC1(1), SDC2(2), SDC3(1), SELE(4), SELL(2), SELP(8), SELPLG(1), SIGLEC1(7), VCAM1(4), VCAN(15) 39026856 261 117 260 98 62 104 54 19 22 0 0.57 1.00 195 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(6), GNAS(5), GNB1(1), HRAS(1), ITGB1(3), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(8), PTPRR(7), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(6), STAT3(1) 9071948 54 45 53 12 16 12 19 5 2 0 0.57 1.00 196 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(5), AR(4), ESR1(5), ESR2(1), HNF4A(2), NR0B1(4), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(3), NR2F6(1), NR4A1(4), NR4A2(3), NR5A2(4), PGR(3), PPARA(1), PPARD(1), RARA(1), RARB(2), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(1), RXRG(4), THRA(1), THRB(1), VDR(3) 11522474 67 52 67 21 19 20 14 4 10 0 0.57 1.00 197 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1G(2), MEF2A(2), MEF2C(3), MEF2D(2) 1618376 9 9 9 6 3 2 1 2 1 0 0.57 1.00 198 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 AKT1(1), APC(9), CAV3(1), DAG1(1), DLG4(1), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(24) 12333620 71 55 71 20 15 26 14 6 10 0 0.58 1.00 199 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4058222 19 18 19 7 4 2 7 1 5 0 0.58 1.00 200 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4058222 19 18 19 7 4 2 7 1 5 0 0.58 1.00 201 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4058222 19 18 19 7 4 2 7 1 5 0 0.58 1.00 202 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(4), DLG4(1), EPHB2(4), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(3), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RAF1(1), RASAL1(3), TEC(2), VAV1(7) 7510888 51 37 50 16 13 17 11 4 6 0 0.58 1.00 203 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(6), ATR(12), CDC25C(1), CHEK1(4), CHEK2(3) 4065520 26 21 26 1 6 7 4 5 4 0 0.58 1.00 204 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 19 ALDH18A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), GATM(1), GLUD1(4), NAGS(1), ODC1(1), OTC(2), SMS(2) 3860642 23 20 23 5 5 9 5 0 4 0 0.58 1.00 205 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(1), AKT3(2), BCR(1), BTK(4), CD19(2), FLOT1(1), GAB1(2), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), NR0B2(1), PDK1(1), PHF11(1), PITX2(3), PLCG2(3), PPP1R13B(4), PREX1(12), PTPRC(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(2), VAV1(7) 14183574 75 58 75 26 16 25 14 7 13 0 0.58 1.00 206 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CXCR4(5), FOS(1), JUN(3), MAPK14(1), MAPK8(2), PLCG1(1), PRKCA(4), SYT1(3) 3539708 20 19 19 8 7 5 4 3 1 0 0.59 1.00 207 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), GRIA2(3), PPP1R1B(1) 1061414 5 5 5 5 0 2 1 0 2 0 0.59 1.00 208 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(2), EGFR(6), HRAS(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(2), MEF2C(3), MEF2D(2), PAK1(1), PRKCA(4), PTK2(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3) 9123746 51 46 49 18 16 13 12 6 4 0 0.59 1.00 209 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), SPAM1(3) 4588306 23 22 23 4 3 7 7 1 5 0 0.60 1.00 210 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(12), EP300(6), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6117860 33 28 32 9 7 9 6 4 7 0 0.60 1.00 211 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(1) 650412 3 3 3 2 0 1 0 0 2 0 0.60 1.00 212 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME2(2), ME3(1), PGK1(1), PKLR(3), PKM2(2), RPIA(1), TKT(1), TPI1(3) 4743700 25 24 25 13 5 7 6 3 4 0 0.60 1.00 213 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(9), CD14(1), CTNNB1(3), DVL1(3), FZD1(1), GJA1(4), GNAI1(2), IRAK1(3), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(2), TOLLIP(1) 7187818 41 34 41 8 9 10 11 5 6 0 0.60 1.00 214 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), EGF(6), EGFR(6), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2) 9513210 53 44 51 10 16 14 11 4 8 0 0.61 1.00 215 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(1), SDS(2), SULT1B1(4), SULT1C2(3), SULT1C4(1) 3393748 21 18 21 4 2 9 6 2 2 0 0.61 1.00 216 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(1), AKT3(2), BCL2L1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), ERBB4(9), F2RL2(1), GAB1(2), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), MET(3), MYC(1), NOLC1(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARD3(5), PARD6A(1), PDK1(1), PIK3CD(3), PPP1R13B(4), PREX1(12), PTK2(4), PTPN1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(2), SOS1(6), SOS2(5), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1) 20089970 119 76 119 33 22 41 29 9 18 0 0.61 1.00 217 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 7 IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(5), STAT1(2), STAT2(1), TYK2(5) 3290686 17 17 17 5 2 9 1 3 2 0 0.61 1.00 218 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 9 GPR37(2), SNCAIP(3), UBE2E2(1), UBE2G2(1), UBE2L6(1) 1465118 8 8 8 3 1 0 5 0 2 0 0.62 1.00 219 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(2), ADSL(1), ADSS(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DDO(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), PC(2) 7056632 41 34 41 16 7 20 8 3 3 0 0.62 1.00 220 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST8SIA1(2) 1506770 8 8 8 6 2 2 3 0 1 0 0.62 1.00 221 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(9), APC2(2), CAMK2B(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(8), CHP(2), CREBBP(12), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(2), CTBP1(1), CTNNB1(3), CUL1(2), DAAM1(1), DAAM2(5), DKK1(3), DKK2(1), DVL1(3), DVL3(2), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NKD1(1), NKD2(2), NLK(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PORCN(2), PPARD(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRICKLE1(5), PRICKLE2(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PSEN1(1), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(2), SENP2(3), SFRP1(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(1), SMAD4(2), TBL1XR1(2), TBL1Y(2), TCF7(1), VANGL1(1), VANGL2(1), WIF1(3), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1) 44342292 243 120 241 79 67 81 41 26 28 0 0.62 1.00 222 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CACNA1C(12), CACNA1D(3), CACNA1F(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CDC42(1), EGFR(6), FSHB(1), GNAS(5), HBEGF(1), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), KRAS(1), LHB(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(2), MMP2(3), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLD1(6), PLD2(2), PRKACB(2), PRKACG(1), PRKCA(4), PRKCD(2), PRKX(1), RAF1(1), SOS1(6), SOS2(5) 34541612 194 107 192 57 53 67 38 18 18 0 0.63 1.00 223 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT2(1), SRD5A1(2), SRD5A2(2) 8668778 50 42 50 12 12 19 6 7 6 0 0.63 1.00 224 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), CD22(5), CD81(1), CR2(9), DAG1(1), FLOT1(1), GSK3A(3), INPP5D(5), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), MAP4K1(2), MAPK1(1), MAPK3(1), NFATC2(4), NR0B2(1), PDK1(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PTPRC(3), RAF1(1), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7) 19587120 106 72 106 34 26 30 19 12 19 0 0.63 1.00 225 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(9), ATF2(2), BMP10(1), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), CTNNB1(3), DVL1(3), FZD1(1), MAP3K7(2), MEF2C(3), MYL2(1), NKX2-5(2), RFC1(1), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6) 9785906 52 44 52 14 10 15 14 6 7 0 0.63 1.00 226 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CUL1(2), E2F1(2), RB1(7), SKP2(1) 2358678 12 11 12 1 1 6 0 0 5 0 0.63 1.00 227 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PRKCA(4) 1368286 7 7 7 1 2 1 3 0 1 0 0.63 1.00 228 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), LTA(2), TGFB1(1), TGFB2(2) 3596846 19 18 19 6 2 6 5 3 3 0 0.64 1.00 229 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 30 ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), DBH(1), DCT(1), DDC(2), FAH(1), GOT2(2), GSTZ1(2), HPD(1), PNMT(2), TAT(1), TH(1), TYR(3) 7878636 42 38 42 14 12 17 4 7 2 0 0.64 1.00 230 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(5), CXCR4(5), GNAI1(2), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(6), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), RAF1(1), RELA(2) 7100954 42 34 42 14 12 15 7 5 3 0 0.64 1.00 231 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(6), PRKCA(4), RELA(2) 2235858 14 11 14 4 5 4 1 2 2 0 0.64 1.00 232 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2) 2378792 12 12 12 3 2 6 1 2 1 0 0.64 1.00 233 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3) 3428992 20 18 20 2 6 6 5 2 1 0 0.65 1.00 234 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(2), TAT(1) 702744 3 3 3 2 1 1 0 1 0 0 0.65 1.00 235 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 ALOX15(2), CYP1A2(1), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1) 6365636 39 32 39 13 13 9 8 4 5 0 0.65 1.00 236 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), CHST1(2), CHST2(3), CHST4(2), CHST6(3), FUT8(2), ST3GAL1(1), ST3GAL4(2) 3427212 20 18 20 10 8 6 4 2 0 0 0.65 1.00 237 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(2) 1174622 8 7 8 0 3 2 1 2 0 0 0.65 1.00 238 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(1), ACACB(8), AKT1(1), AKT3(2), ARAF(3), BRAF(7), CALML6(1), CBL(1), CBLB(4), EXOC7(1), FBP2(1), FLOT1(1), G6PC(2), G6PC2(1), GCK(1), GYS1(1), GYS2(4), HRAS(1), IKBKB(2), INPP5D(5), INSR(7), IRS1(3), IRS2(2), IRS4(2), KRAS(1), LIPE(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK2(1), PCK1(1), PCK2(1), PDE3A(4), PDE3B(3), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(3), PKM2(2), PPARGC1A(5), PPP1R3C(2), PPP1R3D(2), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(1), PTPN1(1), PTPRF(6), PYGB(3), PYGM(4), RAF1(1), RAPGEF1(3), RPS6(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SLC2A4(2), SOCS2(1), SORBS1(5), SOS1(6), SOS2(5), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5) 42874504 226 114 226 79 53 78 49 16 30 0 0.66 1.00 239 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4) 2337496 14 12 14 3 0 5 7 1 1 0 0.66 1.00 240 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2) 7485434 39 34 38 6 10 7 10 4 8 0 0.66 1.00 241 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(2) 3331092 18 17 18 3 5 5 4 4 0 0 0.66 1.00 242 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E3(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(5) 2847644 15 15 15 4 4 6 2 1 2 0 0.66 1.00 243 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(2), PDHA2(5), PDK1(1), PDK2(1), PDK3(2), PDK4(2), PDP2(4), SDHA(1), SUCLA2(2), SUCLG2(1) 7678564 42 37 42 12 5 17 7 8 5 0 0.66 1.00 244 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(1), CREB1(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3R1(1), RB1(7), RELA(2), SP1(1) 4701692 26 22 26 6 7 9 2 2 6 0 0.67 1.00 245 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(2), ANAPC1(4), ANAPC4(3), ANAPC5(4), ATM(6), ATR(12), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDC25B(1), CDC25C(1), CDC27(2), CDC6(4), CDC7(1), CDK7(1), CDKN2C(1), CHEK1(4), CHEK2(3), CREBBP(12), CUL1(2), DBF4(4), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), GADD45G(1), HDAC1(2), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PKMYT1(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), RBL2(5), RBX1(1), SFN(2), SKP1(1), SKP2(1), SMAD2(1), SMAD4(2), SMC1A(2), SMC1B(4), TGFB1(1), TGFB2(2), WEE1(2), YWHAB(1), YWHAQ(1) 36875548 189 108 188 45 45 65 37 18 24 0 0.67 1.00 246 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(4), ATP4A(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX4I1(1), COX4I2(1), COX6B1(1), COX7B2(2), CYC1(4), NDUFA13(2), NDUFA7(1), NDUFAB1(1), NDUFB5(2), NDUFB8(1), NDUFS1(3), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1), UQCRC2(1) 15113624 74 59 74 21 12 24 22 7 9 0 0.68 1.00 247 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GPX6(2), GSR(2), GSS(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1), OPLAH(3) 6086710 33 30 33 10 7 15 7 3 1 0 0.68 1.00 248 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 303668 1 1 1 0 0 1 0 0 0 0 0.68 1.00 249 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 29 AKR1C3(1), ALOX15(2), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(1), LPO(2), LTA4H(2), MPO(3), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PRDX1(1), PRDX6(1), PTGS1(2), TBXAS1(2) 7056988 41 35 41 23 8 13 15 2 3 0 0.68 1.00 250 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(1), DOCK1(3), FOS(1), GAB1(2), HGF(6), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAP4K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MET(3), PAK1(1), PIK3R1(1), PTK2(4), PTPN11(2), PXN(3), RAF1(1), RAP1B(1), RASA1(5), SOS1(6), STAT3(1) 11291786 59 49 58 23 14 19 10 7 9 0 0.69 1.00 251 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G2(2), EIF4G3(3), GHR(2), IRS1(3), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(2), PDK2(1), PDPK1(1), PIK3R1(1), PRKCA(4), RPS6KB1(1) 6769340 36 33 36 12 5 15 9 4 3 0 0.69 1.00 252 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), CKM(2), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(1) 2415104 14 12 14 4 2 7 2 1 2 0 0.70 1.00 253 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(1), AGT(1), AKT1(1), CALR(1), CAMK1G(2), CAMK4(3), CREBBP(12), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(1), HRAS(1), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(3), NFATC2(4), NFATC3(2), NFATC4(1), NKX2-5(2), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(1), RPS6KB1(1), SYT1(3) 11982604 73 51 73 25 19 22 10 13 9 0 0.70 1.00 254 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CD3D(1), FOS(1), FYN(3), HRAS(1), JUN(3), LCK(2), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), RASA1(5), RELA(2), SHC1(1), SOS1(6), SYT1(3), VAV1(7), ZAP70(2) 12376696 69 52 68 11 19 16 12 13 9 0 0.70 1.00 255 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), UAP1(1) 4584390 26 22 26 7 7 9 3 3 4 0 0.70 1.00 256 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(3), CSF1(2), FCGR3A(3), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1) 3779118 22 18 22 8 6 6 5 2 3 0 0.70 1.00 257 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(3), C5(1), C7(7), C8A(3), C9(1) 2928990 15 14 15 7 3 4 5 2 1 0 0.71 1.00 258 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 IFNG(1), IFNGR1(3), JAK1(1), JAK2(3), PLA2G2A(1), PTPRU(5), STAT1(2) 3011048 16 15 16 3 2 7 5 0 2 0 0.71 1.00 259 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2270034 11 11 11 3 2 6 2 1 0 0 0.71 1.00 260 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 89 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), AKAP1(2), AKAP11(7), AKAP12(3), AKAP3(6), AKAP5(1), AKAP6(11), AKAP7(2), AKAP8(3), AKAP9(7), ARHGEF1(2), CHMP1B(1), GNA12(1), GNA14(1), GNAI3(1), GNAL(1), GNAZ(2), GNB1(1), GNB2(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(1), ITPR1(4), KRAS(1), PDE1A(2), PDE1B(1), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE7B(1), PDE8A(5), PDE8B(2), PLCB3(3), PPP3CA(2), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), PRKD3(2), SLC9A1(3), USP5(1) 30555480 173 95 173 42 48 53 35 17 20 0 0.71 1.00 261 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(2), ABL2(5), AKT1(1), AKT3(2), ARAF(3), AREG(2), BRAF(7), CAMK2B(2), CAMK2D(1), CBL(1), CBLB(4), EGF(6), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), EREG(1), GAB1(2), HBEGF(1), HRAS(1), JUN(3), KRAS(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NRG1(3), NRG2(2), NRG3(5), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), RAF1(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), STAT5A(2), TGFA(1) 27584304 159 93 157 54 40 54 31 12 22 0 0.71 1.00 262 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACP1(1), ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(3), CREBBP(12), CSNK2A1(2), CTNNB1(3), CTNND1(3), EGFR(6), EP300(6), ERBB2(1), FARP2(6), FER(2), FGFR1(1), FYN(3), INSR(7), IQGAP1(6), LEF1(3), LMO7(6), MAP3K7(2), MAPK1(1), MAPK3(1), MET(3), MLLT4(1), NLK(2), PARD3(5), PTPN1(1), PTPRB(13), PTPRF(6), PTPRJ(2), PTPRM(6), PVRL1(2), PVRL3(2), PVRL4(5), RAC1(1), SMAD2(1), SMAD4(2), SNAI1(3), SNAI2(2), SORBS1(5), SSX2IP(1), TCF7(1), TGFBR2(3), TJP1(8), VCL(2), WAS(4), WASF3(1), WASL(2), YES1(1) 31278694 182 99 180 50 31 58 50 19 24 0 0.71 1.00 263 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3) 3592396 20 18 20 2 6 6 5 2 1 0 0.72 1.00 264 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(9), NCOA3(4), NCOR2(6), POLR2A(1), RARA(1), RXRA(1), TBP(1) 6895008 34 30 34 13 8 12 5 2 7 0 0.72 1.00 265 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(2), HRAS(1), INSR(7), IRS1(3), JAK2(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(2), SOS1(6), SRF(2), STAT5A(2) 8349802 42 38 42 9 8 14 12 4 4 0 0.72 1.00 266 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC1A(2), CDC42(1), PAK1(1), PDGFRA(8), PIK3R1(1), RAC1(1), WASL(2) 2999656 16 15 16 3 5 4 4 3 0 0 0.72 1.00 267 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(2), FLT3(4), IGF1(3), TGFB1(1), TGFB2(2) 2290504 12 12 12 9 2 6 4 0 0 0 0.72 1.00 268 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(1), APC(9), AR(4), BRAF(7), CCL16(1), DAG1(1), EGFR(6), GNAI1(2), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(2), PIK3CD(3), PIK3R1(1), PITX2(3), PTX3(2), RAF1(1) 13775954 71 57 70 18 21 20 16 5 9 0 0.72 1.00 269 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(1) 817376 3 3 3 0 0 1 0 0 2 0 0.72 1.00 270 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(7), CREB1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), JUN(3), MAP2K1(2), MAPK3(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAF1(1), RPS6KA3(1), SYT1(3) 9434534 57 43 56 14 18 17 7 10 5 0 0.73 1.00 271 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3) 12973530 74 59 74 19 20 31 14 6 3 0 0.73 1.00 272 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3) 12973530 74 59 74 19 20 31 14 6 3 0 0.73 1.00 273 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(12), EP300(6), IKBKB(2), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK14(1), NFKB1(2), RELA(2), TGFBR2(3), TLR2(3) 8069630 41 36 40 11 10 12 8 3 8 0 0.73 1.00 274 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), CPT1A(3), LEPR(10), PRKAA2(3), PRKAG2(4) 3886986 21 20 21 6 8 5 6 1 1 0 0.74 1.00 275 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(1), PON1(4), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1) 2268076 11 11 11 3 3 3 1 2 2 0 0.74 1.00 276 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST3GAL4(2), ST8SIA1(2) 2748498 14 12 14 5 2 5 4 2 1 0 0.74 1.00 277 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CLOCK(5), CRY1(1), CRY2(2), EIF4G2(2), ETV6(4), GSTM3(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(4), PER1(4), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(4) 9949310 55 43 55 13 7 18 17 4 9 0 0.74 1.00 278 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(3), JAK3(7), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5) 3262918 19 16 19 3 2 10 5 1 1 0 0.74 1.00 279 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3) 1626208 8 8 8 3 2 3 2 0 1 0 0.74 1.00 280 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2) 6312592 35 30 35 8 7 15 6 4 3 0 0.74 1.00 281 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(2), F2RL3(1), GNAI1(2), GNB1(1), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(5), PLCB1(6), PRKCA(4), PTGS1(2), PTK2(4), RAF1(1), SYK(1), TBXAS1(2) 6603266 42 32 42 12 13 15 7 3 4 0 0.75 1.00 282 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 52 ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT6(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT2(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), GK(4), GK2(5), GLA(2), GPAM(2), LIPA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), MGLL(1), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(1) 14585320 76 61 76 30 20 35 7 9 5 0 0.75 1.00 283 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(4), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK14(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7) 10354616 59 46 58 12 18 12 12 10 7 0 0.75 1.00 284 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT3(2), HRAS(1), MAP2K1(2), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(6) 3889122 20 18 20 8 4 8 4 2 2 0 0.75 1.00 285 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(2), FOS(1), HRAS(1), JUN(3), KLK2(1), MAP2K1(2), MAPK3(1), MAPK8(2), NGFR(1), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(1), SOS1(6) 4595960 24 22 23 6 7 6 7 3 1 0 0.75 1.00 286 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 244 ACVR1B(3), ACVR2A(3), AMHR2(4), BMPR1A(3), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL3(2), CCR1(2), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CD27(1), CD40(1), CD40LG(2), CNTFR(1), CSF1(2), CSF1R(3), CSF2RB(5), CSF3R(5), CX3CR1(3), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EGF(6), EGFR(6), EPOR(2), FAS(1), FASLG(1), FLT1(8), FLT3(4), FLT4(3), GDF5(4), GH2(2), GHR(2), HGF(6), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL17A(1), IL17RA(3), IL18R1(2), IL18RAP(2), IL1B(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), INHBA(4), INHBC(1), KIT(5), LEPR(10), LIFR(2), LTA(2), LTBR(1), MET(3), MPL(2), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(4), PF4(1), PLEKHO2(3), PRL(1), PRLR(5), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF18(1), VEGFC(4), XCL1(1), XCR1(1) 46077970 260 120 258 107 69 91 54 16 30 0 0.75 1.00 287 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), SELE(4), SELL(2), SELP(8) 4718780 32 23 32 7 8 9 9 2 4 0 0.75 1.00 288 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(3), C5(1), C7(7), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELP(8), SELPLG(1), VCAM1(4) 6211488 36 29 36 10 8 9 10 5 4 0 0.76 1.00 289 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(2), COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), ILVBL(2), PANK3(1), PPCS(1), VNN1(2) 4731952 31 23 31 9 10 9 7 2 3 0 0.76 1.00 290 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), CBS(4), MUT(1) 1333932 7 6 7 0 0 5 0 0 2 0 0.76 1.00 291 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CDK5(1), CFL1(2), CHN1(2), MAP3K1(2), MYL2(1), MYLK(5), NCF2(2), PAK1(1), PDGFRA(8), PIK3R1(1), PLD1(6), PPP1R12B(4), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(5), VAV1(7) 8864578 50 39 50 17 9 18 14 7 2 0 0.76 1.00 292 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2) 1501074 7 7 7 2 3 4 0 0 0 0 0.76 1.00 293 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(2), FUT3(3), ST3GAL4(2) 1955330 9 9 9 4 3 0 5 1 0 0 0.76 1.00 294 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), FOS(1), JUN(3), MAPK3(1), POLR2A(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 3384492 17 16 16 5 5 6 1 2 3 0 0.76 1.00 295 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(19), B3GALT4(1), CDR1(2), DGKI(7), MRPL19(1), PIGK(1), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL4(1), RPL5(1), RPL7(1), RPL8(2), RPLP0(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS8(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1) 14395750 67 58 67 31 15 15 24 11 2 0 0.76 1.00 296 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(1), HEXA(4), SLC33A1(2), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2) 3398732 17 16 17 8 6 4 4 0 3 0 0.76 1.00 297 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(2), CFLAR(1) 1038452 4 4 4 1 0 3 0 0 1 0 0.76 1.00 298 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNB1(1), CCND2(3), CCND3(1), CDK7(1), CDKN2C(1), E2F1(2), RB1(7), RBL1(5) 4212192 21 18 21 3 2 6 4 3 6 0 0.76 1.00 299 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(1), SUCLA2(2) 2517098 12 12 12 6 1 5 2 3 1 0 0.76 1.00 300 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 8 HK1(3), KHK(1), MPI(1), PYGM(4), TPI1(3), TREH(1) 2572278 13 12 13 4 3 2 6 0 2 0 0.76 1.00 301 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CSNK1A1(2), MAPT(4) 2580466 11 11 11 1 1 5 0 1 4 0 0.77 1.00 302 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(1), AKT3(2), CARD11(3), CBL(1), CBLB(4), CD3D(1), CD4(1), CD40LG(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), FOS(1), FYN(3), HRAS(1), ICOS(2), IFNG(1), IKBKB(2), IL10(1), IL4(2), ITK(2), JUN(3), KRAS(1), LCK(2), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCQ(4), PTPRC(3), RASGRP1(1), SOS1(6), SOS2(5), TEC(2), VAV1(7), VAV2(3), VAV3(1), ZAP70(2) 27075046 139 88 138 44 31 40 28 20 20 0 0.77 1.00 303 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 B2M(1), CD3D(1), GZMB(1), ICAM1(2), ITGAL(1), ITGB2(3), PRF1(1) 2139916 10 10 10 6 1 4 2 2 1 0 0.77 1.00 304 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT3(2), APC(9), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(3), DKK2(1), DVL1(3), FSTL1(2), GSK3A(3), LRP1(10), MVP(2), NKD1(1), NKD2(2), PSEN1(1), SENP2(3), SFRP1(1), WIF1(3) 10938100 55 46 55 15 15 16 13 2 9 0 0.77 1.00 305 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(6), EGFR(6), TF(5), TFRC(2) 3479188 20 17 19 2 8 8 2 0 2 0 0.78 1.00 306 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(2), IKBKB(2), LTA(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TANK(4), TNFAIP3(3), TNFRSF1B(1), TRAF1(4), TRAF3(1) 6090804 28 24 28 10 5 4 6 5 8 0 0.78 1.00 307 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(5), CARS(5), DARS(1), DARS2(5), EARS2(2), EPRS(10), FARS2(1), FARSA(2), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(2), LARS2(3), MARS(1), NARS(2), NARS2(2), PARS2(2), RARS(4), RARS2(2), SARS(2), SARS2(2), TARS(3), TARS2(2), VARS(3), VARS2(1), WARS(3), WARS2(1), YARS(1) 14615580 78 58 78 23 9 30 24 5 10 0 0.78 1.00 308 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(1), OXCT1(2) 901926 4 4 4 3 3 1 0 0 0 0 0.78 1.00 309 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP2(1), GPI(5), H6PD(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TAL1(2), TALDO1(1), TKT(1) 5552176 26 25 26 12 6 8 4 3 5 0 0.78 1.00 310 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C9(1) 4329494 24 20 24 11 5 9 6 2 2 0 0.78 1.00 311 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(3), STAT1(2) 2203818 11 10 11 2 2 3 5 0 1 0 0.78 1.00 312 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(1), CREB1(1), HRAS(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NTRK1(3), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1) 4600410 21 20 21 8 6 7 3 3 2 0 0.79 1.00 313 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1) 2756330 16 14 16 4 6 6 1 2 1 0 0.79 1.00 314 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(2), E2F1(2), MDM2(1), MYC(1), PIK3R1(1), POLR1A(2), POLR1B(2), POLR1D(1), RAC1(1), RB1(7), TBX2(3) 4540424 23 19 23 7 5 7 0 4 7 0 0.79 1.00 315 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(1), ITGAM(3), ITGB2(3), SELE(4), SELL(2) 3233726 18 16 18 5 5 5 5 2 1 0 0.79 1.00 316 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(6), MAP2K1(2), MAP3K1(2), MAPK14(1), NCOR2(6), RARA(1), RXRA(1), THRA(1), THRB(1) 4792828 27 23 26 9 12 8 4 0 3 0 0.79 1.00 317 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), RDH11(1), RDH12(2), RDH13(1) 1309724 6 6 6 2 3 0 0 2 1 0 0.79 1.00 318 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AIFM1(1), AKT1(1), AKT3(2), APAF1(1), ATM(6), BAX(1), BCL2L1(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TRADD(1) 21763526 111 74 111 39 32 34 10 17 18 0 0.79 1.00 319 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(5), FOS(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2) 4575846 23 22 23 2 6 7 6 1 3 0 0.79 1.00 320 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(1), ITGB1(3), KLRC1(1), KLRC3(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3R1(1), RAC1(1), SYK(1), VAV1(7) 4237290 20 19 20 6 6 4 5 4 1 0 0.80 1.00 321 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), PANK3(1), PPCS(1) 3808488 25 18 25 8 7 9 4 2 3 0 0.80 1.00 322 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(6), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(1), INHA(3), LHCGR(7), MLH1(1), MSH5(2), NCOR1(5), NRIP1(3), PGR(3), PRLR(5), PTGER2(2), SMPD1(3), VDR(3), ZP2(2) 9107726 53 40 53 21 18 16 5 6 8 0 0.80 1.00 323 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1), SQLE(2) 887152 4 4 4 0 2 1 0 1 0 0 0.80 1.00 324 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(1), ATM(6), ATR(12), BAI1(8), BAX(1), CASP8(1), CASP9(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CCNG1(1), CD82(1), CHEK1(4), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(2), IGF1(3), IGFBP3(1), LRDD(1), MDM2(1), PPM1D(1), RFWD2(4), RRM2B(2), SERPINB5(2), SESN1(3), SESN2(2), SESN3(2), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TSC2(5) 17264754 99 66 99 17 19 36 19 12 13 0 0.80 1.00 325 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 8 ADAR(4), APOBEC2(1), APOBEC3F(1), APOBEC4(3) 1832866 9 8 9 3 4 0 2 1 2 0 0.80 1.00 326 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5) 2816850 13 12 13 5 1 4 5 1 2 0 0.80 1.00 327 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5) 2816850 13 12 13 5 1 4 5 1 2 0 0.80 1.00 328 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(10), PSEN1(1) 2659320 13 11 13 6 2 6 0 1 4 0 0.80 1.00 329 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB4A(3) 1158068 5 5 5 9 3 2 0 0 0 0 0.81 1.00 330 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), GOT2(2), HPD(1), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TAT(1) 5494504 26 25 26 16 8 6 9 3 0 0 0.81 1.00 331 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2) 4446796 22 19 22 12 7 6 6 2 1 0 0.81 1.00 332 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(1), GAPDH(2), GAPDHS(1), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3) 15403764 87 64 87 27 25 33 15 8 6 0 0.81 1.00 333 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(2), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3R1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(1), RALGDS(1), RELA(2) 4640638 23 20 23 6 6 5 3 6 3 0 0.81 1.00 334 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DDC(2), HARS(2), HDC(3), HNMT(2), PRPS1(1), PRPS2(1) 6575498 31 30 31 14 10 11 6 3 1 0 0.81 1.00 335 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 9 ADH5(1), EPX(4), LPO(2), MPO(3), MTHFR(1), PRDX6(1) 2704176 12 12 12 8 1 4 6 1 0 0 0.82 1.00 336 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(1), LPA(11), MAP3K1(2), MAP3K5(3), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RDX(1), ROCK1(5), ROCK2(3), SERPINA4(4), SRF(2), TBXA2R(2) 13379548 76 54 75 27 11 31 18 9 7 0 0.82 1.00 337 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(7), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(1), GNAI1(2), GNB1(1), MAP3K7(2), PIK3R1(1), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5) 6447694 38 30 38 11 9 16 7 4 2 0 0.82 1.00 338 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT3(2), BPNT1(1), ILK(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(3), RBL2(5), SHC1(1), SOS1(6) 4702582 23 21 23 5 4 7 7 3 2 0 0.82 1.00 339 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 12 ADH5(1), EPX(4), LPO(2), MPO(3), PRDX1(1), PRDX6(1) 2761848 12 12 12 9 1 3 7 1 0 0 0.82 1.00 340 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), CERK(3), CREB1(1), CREB3(2), CREB5(3), DAG1(1), EPHB2(4), FOS(1), ITPKA(1), ITPKB(4), JUN(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1) 7865998 42 34 41 11 12 12 10 2 6 0 0.82 1.00 341 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), AOC3(3), CES1(2), CES7(1), DDHD1(4), ESCO1(1), LIPA(2), MYST3(9), MYST4(3), PLA1A(5), PNPLA3(1), PRDX6(1), SH3GLB1(1) 6849084 39 31 39 17 11 14 7 4 3 0 0.82 1.00 342 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2) 1823966 9 8 9 2 4 2 2 1 0 0 0.82 1.00 343 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(6), GGT1(1) 1569604 7 6 7 4 1 2 3 0 1 0 0.82 1.00 344 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 B2M(1), CALR(1), CANX(1), CD4(1), CD8B(1), CIITA(3), CREB1(1), CTSL1(1), CTSS(2), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), HSP90AB1(2), HSPA5(3), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), KIR2DL1(1), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(1), LTA(2), NFYB(1), PSME2(1), TAP1(2), TAPBP(3) 12369754 64 46 63 29 8 19 19 7 11 0 0.82 1.00 345 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(3), RXRA(1) 1557322 7 7 7 3 2 4 0 1 0 0 0.83 1.00 346 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(7), ASH2L(2), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT2(1), EZH1(3), EZH2(4), FBXO11(4), HSF4(1), JMJD6(1), KDM6A(3), MEN1(2), MLL(4), MLL3(20), MLL4(5), MLL5(3), NSD1(8), OGT(2), PRDM2(4), PRDM9(9), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), RBBP5(1), SATB1(2), SETD1A(6), SETD2(4), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(1), SUZ12(3), WHSC1(1), WHSC1L1(12) 30009554 142 92 142 38 24 44 32 11 29 2 0.83 1.00 347 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(1), EGFR(6), MYC(1), POLR2A(1), PRKCA(4), RB1(7), TEP1(3), TERF1(2), TERT(3), TNKS(7), XRCC5(1) 7453394 36 30 35 7 7 12 5 3 9 0 0.83 1.00 348 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 52 ABP1(4), ACAT1(1), ACMSD(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CYP19A1(4), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), DDC(2), GCDH(1), HADHA(2), KMO(2), KYNU(3), SDS(2), TDO2(1), TPH1(1), WARS(3), WARS2(1) 14418534 80 60 80 39 23 26 20 7 4 0 0.83 1.00 349 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(3), LARS2(3), PDHA1(2), PDHA2(5) 2688156 13 12 13 2 1 6 4 1 1 0 0.83 1.00 350 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K1(2), MAPK1(1), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PI3(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), RAF1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7) 13747830 74 53 74 21 16 21 16 9 12 0 0.83 1.00 351 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), RB1(7), WEE1(2) 4531524 21 18 21 1 4 8 1 1 7 0 0.83 1.00 352 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD3D(1), CD4(1) 675510 2 2 2 2 0 1 0 0 1 0 0.83 1.00 353 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(1), AKT3(2), CASP9(2), CDC42(1), CHP(2), HRAS(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NOS3(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCA(4), PRKCG(8), PTK2(4), PXN(3), RAC1(1), RAF1(1), SHC2(2), SPHK2(1) 18488860 106 67 106 36 32 30 16 17 11 0 0.83 1.00 354 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), CCND2(3), CCND3(1), CTNNB1(3), DVL1(3), DVL3(2), FZD1(1), FZD10(1), FZD3(4), FZD6(2), FZD7(1), FZD9(2), JUN(3), LDLR(3), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(5), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), RAC1(1), SFRP4(3), TCF7(1), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT6(2), WNT7A(2), WNT7B(1) 16330076 103 64 102 26 32 32 22 10 7 0 0.83 1.00 355 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4) 4394820 20 19 20 4 4 6 8 1 1 0 0.83 1.00 356 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(5) 2905494 13 13 13 5 3 5 1 3 1 0 0.84 1.00 357 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GSS(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1) 4947866 25 23 25 8 7 12 4 2 0 0 0.84 1.00 358 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(4), FCER1A(2), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PIK3R1(1), PLA2G4A(5), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7) 11048638 61 47 60 19 17 14 12 11 7 0 0.84 1.00 359 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(1), GALNT10(1), GALNT2(2), GALNT3(2), GALNT6(2), GALNT8(2), GCNT1(2), ST3GAL1(1), ST3GAL4(2) 3526536 15 14 14 5 3 4 6 1 1 0 0.85 1.00 360 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(12), EP300(6), FYN(3), IL2RG(1), IL7R(2), JAK1(1), JAK3(7), LCK(2), NMI(1), PIK3R1(1), STAT5A(2) 7041502 38 31 37 13 6 15 9 4 4 0 0.85 1.00 361 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT3(1), AGPAT6(1), ENPP2(6), ENPP6(1), PAFAH1B1(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLD1(6), PLD2(2), PPAP2B(1) 6222702 35 28 35 18 6 16 8 1 4 0 0.85 1.00 362 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(6), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JUN(3), LYN(1), MAP3K14(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(3), NFKB1(2), NFKB2(2), NOD1(4), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), RELA(2), TJP1(8) 19090856 95 65 93 19 27 22 19 10 17 0 0.85 1.00 363 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(3), HLA-DRA(1), HLA-DRB1(1), LCK(2), PTPRC(3), ZAP70(2) 2464054 14 11 14 6 2 7 2 1 2 0 0.85 1.00 364 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(4), ADRBK2(1), CALML6(1), CAMK2B(2), CAMK2D(1), CLCA1(4), CLCA2(4), CLCA4(2), CNGA3(3), CNGA4(4), CNGB1(4), GNAL(1), GUCA1A(2), PRKACB(2), PRKACG(1), PRKG1(4), PRKG2(3), PRKX(1) 7900530 44 34 44 11 16 10 5 5 8 0 0.86 1.00 365 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2) 3552346 15 15 15 5 3 6 2 3 1 0 0.86 1.00 366 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), JAK1(1), JAK3(7), JUN(3), LCK(2), MAP2K1(2), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1) 6428648 36 29 35 9 9 13 9 2 3 0 0.86 1.00 367 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(2), ATM(6), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDAN1(3), CDC25B(1), CDC25C(1), CDC6(4), CDC7(1), CDH1(3), CHEK1(4), CHEK2(3), DTX4(1), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MPEG1(4), MPL(2), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), SKP2(1), SMAD4(2), TBC1D8(1), TGFB1(1), WEE1(2) 29837428 142 92 141 37 30 51 29 11 21 0 0.87 1.00 368 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(5), ALG1(1), ALG13(6), ALG2(2), ALG6(2), B3GALT6(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1C1(1), CHPF(1), CHST1(2), CHST12(1), CHST2(3), CHST3(2), CHST4(2), CHST6(3), DDOST(1), EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), FUT8(2), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GANAB(5), GCNT1(2), GCNT3(2), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), NDST1(2), NDST2(1), NDST3(4), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(1), XYLT1(2) 29176692 148 95 147 54 34 57 28 17 12 0 0.87 1.00 369 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 30 ACP1(1), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CYP19A1(4), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), PON1(4) 7658806 47 34 47 26 16 12 14 3 2 0 0.87 1.00 370 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(6), ATR(12), BRCA1(6), CCNB1(1), CDC25B(1), CDC25C(1), CHEK1(4), CHEK2(3), EP300(6), GADD45A(1), MDM2(1), PRKDC(11), RPS6KA1(2), WEE1(2), YWHAQ(1) 11367080 58 46 57 7 12 18 12 9 7 0 0.87 1.00 371 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2) 3034544 14 14 14 9 2 8 1 2 1 0 0.87 1.00 372 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOA(1), ALDOB(2), DERA(1), FBP2(1), GPI(5), H6PD(2), PFKL(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TALDO1(1), TKT(1) 6312058 27 27 27 12 7 8 5 2 5 0 0.87 1.00 373 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1) 1701146 6 6 6 6 1 3 0 0 2 0 0.87 1.00 374 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELE(4), SELL(2) 3655764 21 16 21 3 5 6 7 2 1 0 0.88 1.00 375 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3B2(1), CYP1A2(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), MGST1(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2) 14629286 82 59 82 33 24 22 25 7 4 0 0.88 1.00 376 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(2), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH9A1(2), GAD1(4), GAD2(5), HADHA(2), HMGCL(1), OXCT1(2), PDHA1(2), PDHA2(5), SDS(2) 6966742 38 31 38 16 8 18 4 4 4 0 0.88 1.00 377 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(1), AOC3(3), CARM1(1), CNDP1(3), DDC(2), HARS(2), HARS2(2), HDC(3), HNMT(2), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), PRPS1(1), PRPS2(1), UROC1(1), WBSCR22(3) 10716134 52 45 52 17 22 15 8 4 3 0 0.88 1.00 378 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), NSD1(8), OGDH(3), OGDHL(4), PIPOX(1), PLOD1(4), PLOD2(4), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(6), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(2) 15838974 77 58 77 33 9 24 22 8 14 0 0.88 1.00 379 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(2), FUCA1(1), HEXA(4), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2) 3513542 18 14 18 4 4 5 7 0 2 0 0.89 1.00 380 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), FYN(3), JUN(3), MAPK14(1), THBS1(1) 1984344 10 9 9 1 2 2 4 2 0 0 0.89 1.00 381 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2) 2883956 13 13 13 8 2 8 1 2 0 0 0.89 1.00 382 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TANK(4), TNFRSF1A(2), TRADD(1) 6698318 33 27 32 10 8 9 6 3 7 0 0.89 1.00 383 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST8SIA1(2) 2913504 12 11 12 5 2 5 2 2 1 0 0.89 1.00 384 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(9), CTNNB1(3), DLL1(1), DVL1(3), FZD1(1), NOTCH1(10), PSEN1(1) 5808318 28 24 28 8 6 10 5 1 6 0 0.89 1.00 385 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC3(1), PSMD14(3), RPN1(1), UBE2A(1), UBE3A(5) 3479544 15 15 15 3 4 6 3 0 2 0 0.89 1.00 386 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(8), FLT4(3), HIF1A(1), HRAS(1), NOS3(1), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), SHC1(1), VHL(1) 7939156 35 32 35 15 9 10 6 7 3 0 0.89 1.00 387 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), CARM1(1), DBH(1), DCT(1), DDC(2), ECH1(1), ESCO1(1), FAH(1), GOT2(2), GSTZ1(2), HPD(1), LCMT1(2), MYST3(9), MYST4(3), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TYR(3), TYRP1(2), WBSCR22(3) 15374572 77 59 77 23 21 29 9 10 8 0 0.89 1.00 388 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(1), ATM(6), BAX(1), E2F1(2), GADD45A(1), MDM2(1), RB1(7) 4723408 19 18 19 1 3 7 1 2 6 0 0.89 1.00 389 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), ARHGDIB(1), BAG4(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), GSN(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK8(2), MDM2(1), NFKB1(2), NUMA1(4), PRKCD(2), PRKDC(11), PSEN1(1), PSEN2(2), PTK2(4), RASA1(5), RB1(7), RELA(2), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 19149418 82 63 82 26 16 24 11 8 23 0 0.90 1.00 390 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH1(3), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2) 1973842 9 8 9 5 3 4 1 1 0 0 0.90 1.00 391 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACADL(2), ACADM(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ANGPTL4(1), APOA2(1), APOA5(3), CD36(1), CPT1A(3), CPT1C(3), CPT2(1), CYP27A1(1), CYP4A22(2), CYP7A1(3), DBI(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(5), HMGCS2(1), ILK(1), LPL(3), MMP1(3), NR1H3(2), PCK1(1), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(1), RXRA(1), RXRG(4), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(2), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(1), UCP1(2) 17498112 90 65 90 39 24 25 27 6 8 0 0.90 1.00 392 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(7), MAP2(8), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(3) 4900162 23 20 23 7 6 3 9 3 2 0 0.90 1.00 393 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 34 ARSD(1), ARSE(2), B4GALT6(1), CERK(3), ENPP7(4), GAL3ST1(1), GALC(1), GLA(2), NEU1(2), NEU2(2), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(2), SMPD1(3), SMPD2(1), SMPD3(3), SPHK2(1), SPTLC2(3), UGT8(5) 8350870 41 33 41 13 11 10 10 5 5 0 0.90 1.00 394 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), PC(2), PCK1(1), SDHA(1), SUCLA2(2), SUCLG2(1) 5541852 25 23 25 8 5 8 3 5 4 0 0.90 1.00 395 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(4), ABCC2(4), ABCG2(1), CES1(2), CES2(1), CYP3A4(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1) 5763106 24 24 24 7 5 10 6 2 1 0 0.90 1.00 396 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 AGA(2), ARSB(1), FUCA1(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2), SPAM1(3) 8481878 41 32 41 10 6 13 14 2 6 0 0.90 1.00 397 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(5), HRAS(1), JUN(3), MAP2K1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(1), PLCG1(1), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3) 7794620 38 34 37 11 14 8 9 5 2 0 0.90 1.00 398 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), PFKFB1(2), PFKM(4), PFKP(2), PMM1(1), TPI1(3) 6506434 35 28 35 13 12 8 10 3 2 0 0.90 1.00 399 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(1), ABAT(2), ACADS(2), ACAT1(1), ACSM1(5), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(3), DDHD1(4), GAD1(4), GAD2(5), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), OXCT1(2), PDHA1(2), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(2), RDH13(1) 11071778 64 45 64 23 16 24 8 10 6 0 0.90 1.00 400 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 AKT1(1), ATM(6), BAX(1), CPB2(2), CSNK1A1(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(1), NFKBIB(1) 4744590 20 19 20 2 4 8 3 3 2 0 0.90 1.00 401 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTR(4) 4733020 23 19 23 10 3 11 6 1 2 0 0.90 1.00 402 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(8), FLNC(11), FSCN3(1), GDI1(1), GDI2(1), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASL(2) 11843586 55 47 55 28 11 23 12 2 7 0 0.90 1.00 403 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2) 3593286 15 15 15 3 5 8 0 2 0 0 0.90 1.00 404 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PPT1(1) 2306524 8 8 8 2 1 0 2 3 2 0 0.91 1.00 405 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), BCL2A1(1), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CD40(1), CD40LG(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NTRK1(3), PTPN13(3), SFRS2IP(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(1), TRAF6(1) 12079436 57 43 57 23 12 19 7 7 12 0 0.91 1.00 406 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(2), SULT1E1(1), SULT2A1(3) 2544332 10 10 10 5 2 3 2 2 1 0 0.91 1.00 407 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(2), SDS(2) 1318802 4 4 4 5 0 1 1 0 2 0 0.91 1.00 408 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(1), HRAS(1), IRS1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(1), RAF1(1), SHC1(1), SOS1(6) 4499306 18 18 18 2 4 6 5 2 1 0 0.91 1.00 409 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(1), FADD(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 2346218 10 8 10 4 3 2 0 2 3 0 0.91 1.00 410 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(1), GOT2(2), PAH(1), TAT(1), YARS(1) 2211650 8 8 8 3 4 1 1 1 1 0 0.91 1.00 411 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), HTR2C(2), PLCB1(6) 1924358 9 8 9 4 3 4 0 2 0 0 0.91 1.00 412 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(3), CAMK2B(2), CAMK2D(1), CDK5(1), FYN(3), GNAI1(2), GNB1(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(4), MYLK(5), PLCG1(1), PRKCA(4), RAF1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2), SYT1(3) 11315994 55 47 55 13 12 18 14 5 6 0 0.91 1.00 413 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1), PRKCA(4) 1819516 6 6 6 3 2 2 1 0 1 0 0.91 1.00 414 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 JAK1(1), JAK2(3), JAK3(7), PIAS1(2), PIAS3(2), PTPRU(5) 3736754 20 16 20 3 1 11 5 1 2 0 0.91 1.00 415 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(1), SHC1(1), SOS1(6) 2388582 9 9 9 1 2 1 4 1 1 0 0.91 1.00 416 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1) 3175520 16 14 16 4 6 6 1 2 1 0 0.91 1.00 417 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(1), HADHA(2), HADHB(2), SDS(2) 2252946 8 8 8 7 1 1 2 2 2 0 0.91 1.00 418 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(2), APOA2(1), CD36(1), CREBBP(12), EP300(6), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), MYC(1), NCOA1(5), NCOR1(5), NCOR2(6), NR0B2(1), NR1H3(2), NRIP1(3), PIK3R1(1), PPARA(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RB1(7), RELA(2), RXRA(1), SP1(1), STAT5A(2) 16377780 81 59 79 34 17 27 13 9 15 0 0.91 1.00 419 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(2), BCMO1(1) 1037384 3 3 3 3 0 1 1 0 1 0 0.91 1.00 420 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CASP10(3), CASP8(1), CASP9(2), GZMB(1), JUN(3), PRF1(1) 3454802 15 15 14 8 3 5 3 2 2 0 0.91 1.00 421 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(1), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL4(2) 2168218 9 9 9 10 2 4 2 1 0 0 0.91 1.00 422 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1), SCAP(4), SREBF1(2), SREBF2(2) 5027432 24 21 24 10 5 9 5 3 2 0 0.92 1.00 423 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(1), AKT3(2), CASP8(1), CCL3(2), CD14(1), CD40(1), CD80(2), CD86(1), CHUK(2), FADD(1), FOS(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IKBKB(2), IKBKE(3), IL12A(1), IL12B(2), IL1B(1), IRAK1(3), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(2), STAT1(2), TBK1(2), TLR1(2), TLR2(3), TLR3(2), TLR5(2), TLR7(3), TLR8(1), TLR9(1), TOLLIP(1), TRAF3(1), TRAF6(1) 23394718 117 76 115 35 29 35 24 15 14 0 0.92 1.00 424 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(4), EEA1(1), GSK3A(3), LYN(1), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PLCG1(1), PRKCE(3), RAC1(1), RPS6KB1(1), VAV2(3) 6962292 32 27 32 13 8 4 10 3 7 0 0.92 1.00 425 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), AKT3(2), BRAF(7), DAG1(1), DRD2(2), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), PI3(1), PIK3CB(2), PITX2(3), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), RAF1(1), RGS20(1), SHC1(1), SOS1(6), SOS2(5), STAT3(1) 15750330 88 60 87 21 23 28 19 5 13 0 0.92 1.00 426 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(1), AKT3(2), GSK3A(3), IL4R(1), IRS1(3), IRS2(2), JAK1(1), JAK3(7), MAP4K1(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(3), PIK3R1(1), PPP1R13B(4), RAF1(1), SHC1(1), SOS1(6), SOS2(5), STAT6(1) 9492028 47 37 47 15 8 17 11 4 7 0 0.92 1.00 427 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB11(5), ABCB4(6), ABCC1(4), ABCC3(1) 3186912 16 14 16 7 8 4 3 1 0 0 0.92 1.00 428 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3) 3831272 17 16 17 2 7 5 2 1 2 0 0.92 1.00 429 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), UGDH(2) 2317560 9 9 9 1 2 6 0 1 0 0 0.92 1.00 430 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(1), GNS(1), GUSB(2), HEXA(4), IDS(1), IDUA(2) 2919378 11 10 11 0 1 3 3 1 3 0 0.92 1.00 431 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), FUK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), MTMR1(1), MTMR2(1), MTMR6(4), PFKFB1(2), PFKL(2), PFKM(4), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), TPI1(3) 10174124 51 42 51 15 16 10 13 6 6 0 0.92 1.00 432 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPN2(2), CAPNS2(1), EP300(6), HDAC1(2), MEF2D(2), NFATC2(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SYT1(3) 6598994 33 26 32 8 10 7 6 6 4 0 0.93 1.00 433 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALML6(1), CDS1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5D(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), OCRL(5), PI4KA(4), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3C3(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PRKCA(4), PRKCG(8), SYNJ1(2), SYNJ2(3) 33604442 198 97 197 55 60 55 38 16 29 0 0.93 1.00 434 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), HADHA(2), PECR(1), SCP2(1) 4528320 18 18 18 7 4 5 5 1 3 0 0.93 1.00 435 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(1), E2F1(2), HRAS(1), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(1), PIK3R1(1), RAC1(1), RAF1(1), RB1(7), RELA(2) 4943950 21 18 21 2 3 7 1 4 6 0 0.93 1.00 436 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(2), FUCA1(1), HEXA(4), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2) 4558580 22 17 22 6 4 7 8 1 2 0 0.93 1.00 437 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(1), CHRNB1(1), CHRNG(4), MUSK(2), PIK3R1(1), PTK2(4), RAPSN(3), TERT(3) 3938606 19 17 19 9 9 7 1 1 1 0 0.93 1.00 438 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2) 2153800 8 8 8 0 1 5 1 1 0 0 0.93 1.00 439 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2) 2153800 8 8 8 0 1 5 1 1 0 0 0.93 1.00 440 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CFL1(2), E2F1(2), MDM2(1), PRB1(2) 1870246 8 7 8 4 1 5 1 1 0 0 0.93 1.00 441 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), CTNNB1(3), PTK2(4), PXN(3), VCL(2) 5192438 27 21 27 14 8 9 4 5 1 0 0.93 1.00 442 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), CASP1(1), CASP7(2), CASP8(1), GAPDH(2), INSR(7), ITCH(2), MAGI1(5), MAGI2(7), RERE(2), WWP1(1) 6378808 32 24 32 10 6 11 6 3 6 0 0.93 1.00 443 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL2RG(1), IL4(2), IL4R(1), IRS1(3), JAK1(1), JAK3(7), RPS6KB1(1), SHC1(1), STAT6(1) 4071928 19 16 19 6 3 9 5 0 2 0 0.93 1.00 444 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), ITPKA(1), ITPKB(4) 1687262 6 6 6 2 4 0 1 0 1 0 0.93 1.00 445 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(3), MEF2D(2), PPARA(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(3) 5542920 30 22 30 10 11 5 3 7 4 0 0.93 1.00 446 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(1) 967608 3 3 3 2 0 2 1 0 0 0 0.93 1.00 447 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 42 ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AGPAT3(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), CEL(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), GK(4), GLA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(1) 11725394 54 46 54 25 13 27 5 5 4 0 0.93 1.00 448 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), FOS(1), HRAS(1), IL6R(1), JAK1(1), JAK2(3), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(2), RAF1(1), SHC1(1), SOS1(6), SRF(2), STAT3(1) 6555740 35 28 34 7 8 12 10 3 2 0 0.93 1.00 449 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTAP(1), MTR(4), TAT(1) 5640642 26 22 26 11 4 12 6 1 3 0 0.93 1.00 450 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(2), MAP3K5(3), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF9(1) 5344806 26 21 25 9 5 6 9 2 4 0 0.93 1.00 451 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(1), BRAF(7), CREB1(1), CREB3(2), CREB5(3), CREBBP(12), DAG1(1), EGR1(2), EGR2(6), EGR3(1), FRS2(3), JUN(3), MAP1B(3), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3C2G(6), PIK3CD(3), PIK3R1(1), PTPN11(2), RPS6KA3(1), SHC1(1), TH(1) 13677876 76 53 75 28 24 26 14 6 6 0 0.93 1.00 452 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), GOT2(2), PAH(1), TAT(1), YARS(1) 2348888 8 8 8 5 4 2 0 1 1 0 0.93 1.00 453 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS2(3), PDHA1(2), PDHA2(5), VARS(3), VARS2(1) 5037400 24 20 24 5 4 10 6 1 3 0 0.93 1.00 454 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 GORASP1(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PIK3CD(3), PIK3R1(1), SYT1(3), TRAF3(1), TRAF5(2), TRAF6(1) 8770594 39 34 39 10 11 14 3 7 4 0 0.93 1.00 455 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(2), DFFB(2), GZMB(1), TOP2A(2), TOP2B(4) 2721976 11 10 11 5 1 4 4 1 1 0 0.93 1.00 456 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PLCG1(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2) 5861184 28 24 27 5 8 7 8 2 3 0 0.94 1.00 457 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(1), DHRS2(1), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3) 3890012 17 16 17 2 8 4 2 1 2 0 0.94 1.00 458 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFB(2), FADD(1), JUN(3), MADD(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), RB1(7), SPTAN1(2), TNFRSF1A(2), TRADD(1) 10863874 44 40 43 16 9 15 5 2 13 0 0.94 1.00 459 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 CPO(1), FECH(2), GATA1(2), HBB(2), UROD(1) 2209870 8 8 8 3 2 3 0 1 2 0 0.94 1.00 460 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 144 AKT1(1), AKT3(2), BCL2L1(1), CBL(1), CBLB(4), CCND2(3), CCND3(1), CNTFR(1), CREBBP(12), CSF2RB(5), CSF3R(5), EP300(6), EPOR(2), GH2(2), GHR(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL13RA2(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), LIFR(2), MPL(2), MYC(1), OSMR(2), PIAS1(2), PIAS3(2), PIAS4(2), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(5), PTPN11(2), SOCS2(1), SOCS5(3), SOS1(6), SOS2(5), SPRED1(1), SPRED2(1), STAM(1), STAM2(2), STAT1(2), STAT2(1), STAT3(1), STAT4(4), STAT5A(2), STAT6(1), TYK2(5) 37361666 202 105 200 83 42 71 47 20 22 0 0.94 1.00 461 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(1), CAMK2B(2), CAMK4(3), CNR1(2), CREBBP(12), CSNK2A1(2), EGR2(6), EGR3(1), EP300(6), FCER1A(2), FCGR3A(3), FKBP1B(1), FOS(1), GATA3(5), GRLF1(11), GSK3A(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL1B(1), IL4(2), ITK(2), KPNA5(2), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(3), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIB(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(3), RELA(2), SFN(2), SLA(1), SP1(1), SP3(1), TGFB1(1), TRPV6(3), VAV1(7), VAV2(3), VAV3(1), XPO5(1) 24820854 139 80 138 44 40 32 30 17 20 0 0.94 1.00 462 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(1), CD3D(1), DAG1(1), EPHB2(4), ITK(2), ITPKA(1), ITPKB(4), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLCG1(1), PTPRC(3), RAF1(1), RASGRP1(1), RASGRP3(6), RASGRP4(4), SOS1(6), SOS2(5), VAV1(7), ZAP70(2) 14819924 76 56 76 29 20 23 18 5 10 0 0.94 1.00 463 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(2), EGR2(6), EGR3(1), MAP3K1(2), MYC(1), NFATC2(4), NFKB1(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(3), VIP(1) 7466566 41 29 41 10 14 8 5 8 6 0 0.94 1.00 464 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(2), ATM(6), ATR(12), E2F1(2), HDAC1(2), RB1(7), SKP2(1), TGFB1(1), TGFB2(2) 7767920 35 29 35 7 8 11 5 3 8 0 0.94 1.00 465 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 IL6R(1), JAK1(1), JAK2(3), JAK3(7), PIAS3(2), PTPRU(5), STAT3(1) 4136186 20 17 20 3 2 11 4 1 2 0 0.94 1.00 466 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), ARHGEF1(2), GNA12(1), GNB1(1), MYL2(1), MYLK(5), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5) 5569976 30 23 30 9 6 13 6 3 2 0 0.94 1.00 467 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SP1(1), SP3(1), SYT1(3) 5691372 26 22 26 5 9 7 2 5 3 0 0.94 1.00 468 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(1) 869530 2 2 2 3 0 1 1 0 0 0 0.94 1.00 469 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(1), CREBBP(12), EP300(6), ERCC3(1), ESR1(5), GRIP1(3), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MEF2C(3), NCOR2(6), NR0B1(4), NRIP1(3), POLR2A(1), TBP(1) 12822586 63 48 62 19 18 17 13 7 8 0 0.94 1.00 470 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT3(2), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PIK3CB(2), PITX2(3), PLD1(6), PLD2(2), PLD3(1), VN1R1(2) 12327212 55 45 55 15 11 21 8 6 9 0 0.95 1.00 471 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADH(1), HADHA(2), HSD17B4(1), SIRT2(2), VNN2(5) 3154338 11 10 11 7 0 3 3 1 4 0 0.95 1.00 472 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(1), CASP9(2), CHUK(2), GHR(2), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(2) 3258112 13 11 13 8 1 4 2 4 2 0 0.95 1.00 473 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(1), ACP6(2), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), DHRS2(1), PON1(4), PON2(1), PON3(1) 4730528 23 18 23 10 6 8 3 2 4 0 0.95 1.00 474 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), BCR(1), CAPN1(2), CAPNS2(1), FYN(3), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), SOS1(6), TLN1(3), VCL(2) 12940422 68 51 67 21 17 22 14 10 5 0 0.95 1.00 475 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TGFB1(1), TGFB2(2), TOLLIP(1), TRAF6(1) 8061264 39 32 38 14 14 10 6 5 4 0 0.95 1.00 476 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(2), IFNB1(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF11A(1), TNFSF11(1), TRAF6(1) 3013540 14 11 14 2 5 4 0 3 2 0 0.95 1.00 477 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CALML6(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(12), CTNNB1(3), DCT(1), DVL1(3), DVL3(2), EDNRB(3), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), GNAI1(2), GNAI3(1), GNAS(5), HRAS(1), KIT(5), KRAS(1), LEF1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), POMC(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), TCF7(1), TYR(3), TYRP1(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1) 29302182 171 90 170 56 48 60 30 18 15 0 0.95 1.00 478 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 B4GALT1(1), G6PC(2), G6PC2(1), GALK2(1), GALT(1), GANC(3), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), MGAM(3), PFKL(2), PFKM(4), PFKP(2), RDH11(1), RDH12(2), RDH13(1), UGP2(4) 9542224 44 39 44 16 17 13 5 6 3 0 0.95 1.00 479 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), HADHA(2), SDS(2) 3292822 12 12 12 5 1 6 2 1 2 0 0.96 1.00 480 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 23 B4GALT1(1), FBP2(1), G6PC(2), GALK2(1), GALT(1), GANAB(5), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), MGAM(3), PFKM(4), PFKP(2) 7869914 36 32 36 15 12 16 3 4 1 0 0.96 1.00 481 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(2), SDHA(1) 1766116 5 5 5 2 0 2 1 2 0 0 0.96 1.00 482 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12B(1), ALOX15(2), ALOX15B(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(1), GPX5(1), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2) 10561808 56 41 56 28 15 13 20 2 6 0 0.96 1.00 483 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(4), EIF2B5(1), EIF5(1) 3140988 13 13 13 5 7 4 1 0 1 0 0.96 1.00 484 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP54(1), SRP72(1), SRPR(2) 2013536 6 6 6 3 2 2 2 0 0 0 0.96 1.00 485 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 30 GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(4), TAF1(10), TAF2(6), TAF4(1), TAF4B(4), TAF5L(1), TAF6L(1), TAF7L(1), TAF9(2), TBPL2(1) 8734104 37 34 37 10 8 13 6 5 5 0 0.96 1.00 486 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), ESCO1(1), GOT2(2), HPD(1), LPO(2), MPO(3), MYST3(9), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1) 8770238 40 34 40 22 10 12 11 4 3 0 0.96 1.00 487 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(5), AMY2B(3), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(7), ENPP3(3), ENTPD7(1), ERCC3(1), G6PC(2), G6PC2(1), GANC(3), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), IFIH1(3), MGAM(3), NUDT8(1), PYGB(3), PYGM(4), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2), TREH(1), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UXS1(3) 32156056 159 91 159 49 43 52 40 10 14 0 0.96 1.00 488 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 AKT1(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(4), CDC42(1), CFL1(2), CFL2(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(4), ITPR2(11), ITPR3(1), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CD(3), PIK3CG(9), PIK3R1(1), PITX2(3), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(3), WASL(2) 18413388 88 63 87 35 17 26 20 9 16 0 0.96 1.00 489 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(3), AKT1(1), GNAS(5), GNB1(1), NFKB1(2), NOS3(1), PIK3R1(1), RELA(2), SYT1(3) 4352634 19 15 19 9 5 4 4 5 1 0 0.96 1.00 490 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1) 6562148 29 26 29 11 7 11 4 2 5 0 0.96 1.00 491 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 56 AADAT(1), ABP1(4), ACAT1(1), ACMSD(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CARM1(1), CYP1A2(1), DDC(2), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), INMT(2), KMO(2), KYNU(3), LCMT1(2), LNX1(2), NFX1(1), OGDH(3), OGDHL(4), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), TDO2(1), TPH1(1), TPH2(5), WARS(3), WARS2(1), WBSCR22(3) 15932068 79 58 79 31 21 28 14 9 7 0 0.96 1.00 492 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADHA(2), PLOD1(4), PLOD2(4), PLOD3(5), SDS(2) 10099720 48 38 48 23 5 17 16 4 6 0 0.96 1.00 493 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), GCDH(1), HADHA(2), SDS(2) 2113928 6 6 6 7 1 1 2 0 2 0 0.96 1.00 494 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1) 5233378 22 19 22 9 3 8 4 2 5 0 0.96 1.00 495 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), WEE1(2) 3709342 14 13 14 1 4 6 1 1 2 0 0.97 1.00 496 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(5), CAPN7(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(3), FYN(3), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK10(1), MAPK4(1), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PDPK1(1), PIK3R2(3), PTK2(4), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(3), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(5), SHC1(1), SHC3(2), SORBS1(5), SOS1(6), TLN1(3), TNS1(6), VASP(2), VAV2(3), VAV3(1), VCL(2) 36879464 195 104 194 67 45 75 42 13 20 0 0.97 1.00 497 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGEF2(3), COPA(8), GBF1(4), KDELR2(1) 4367764 18 16 18 9 4 4 6 3 1 0 0.97 1.00 498 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), COPS5(2), CREB1(1), EP300(6), HIF1A(1), JUN(3), NOS3(1), VHL(1) 4582432 19 17 17 8 2 7 6 3 1 0 0.97 1.00 499 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(2), FECH(2), PPOX(1), UROD(1) 2065156 6 6 6 2 1 3 0 1 1 0 0.97 1.00 500 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(2), FADD(1), IKBKB(2), IRAK1(3), MAP3K1(2), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(2), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6253140 25 21 25 10 8 5 4 3 5 0 0.97 1.00 501 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 AKT1(1), DAG1(1), DGKA(3), ETFA(2), GCA(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(6), PIK3CD(3), PIK3R1(1), RIPK3(1), SGCB(1), VASP(2) 12846260 57 46 57 19 19 16 11 3 8 0 0.97 1.00 502 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1A(2), NCK1(2), NCKAP1(4), NTRK1(3), RAC1(1), WASF3(1), WASL(2) 4129422 16 15 16 11 2 7 2 2 3 0 0.97 1.00 503 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(1), MST1R(1) 1782314 5 5 5 2 2 2 1 0 0 0 0.97 1.00 504 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), CREB1(1), SYT1(3) 3177478 12 11 12 7 5 1 1 4 1 0 0.97 1.00 505 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(2), FPR1(1), GNB1(1), HRAS(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PAK1(1), PIK3C2G(6), PLCB1(6), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(3) 10537956 55 41 55 19 19 16 6 10 4 0 0.97 1.00 506 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(1), DIAPH1(1), FYN(3), GSN(2), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PIK3R1(1), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), TLN1(3) 9542402 42 37 42 11 10 12 8 9 3 0 0.97 1.00 507 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(3), ALPP(2), ALPPL2(1), GCH1(1) 1834468 7 6 7 4 3 3 0 1 0 0 0.97 1.00 508 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(3), EEF2K(3), GADD45A(1), MAP2K3(2), MAP2K6(2), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), SRF(2), TRAF6(1) 9192632 46 34 46 15 7 15 13 6 5 0 0.97 1.00 509 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(2), CAMK2D(1), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFAT5(2), PDE6A(2), PDE6B(3), PDE6H(2), SLC6A13(4), TF(5) 9814920 43 37 43 12 17 9 8 1 8 0 0.97 1.00 510 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(4), ADC(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), GATM(1), NAGS(1), ODC1(1), OTC(2), SMS(2) 7199388 32 26 32 8 10 12 6 2 2 0 0.97 1.00 511 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(2) 1115170 3 3 3 2 0 2 1 0 0 0 0.97 1.00 512 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1A(2), CDC42(1), RAC1(1), WASL(2) 2180856 7 7 7 6 1 3 2 1 0 0 0.97 1.00 513 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(1), B4GALT3(1), B4GALT5(2), DDOST(1), FUT8(2), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN1(1), ST6GAL1(1) 5405504 27 21 27 14 11 9 2 3 2 0 0.98 1.00 514 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(5), CASP9(2), CES1(2) 3102540 13 10 13 5 3 2 5 2 1 0 0.98 1.00 515 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 46 ACCN1(4), ADCY4(3), ADCY8(13), CACNA1A(7), CACNA1B(1), GNAS(5), GNAT3(1), GNB1(1), GRM4(1), ITPR3(1), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(2), PRKACG(1), PRKX(1), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS2R1(3), TAS2R10(3), TAS2R16(4), TAS2R38(2), TAS2R39(1), TAS2R4(1), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R5(1), TAS2R7(1), TAS2R8(1), TAS2R9(3) 15289132 81 55 81 34 22 25 20 7 7 0 0.98 1.00 516 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(5), APOC2(2), CYP7A1(3), LDLR(3), LIPC(1), LPL(3), LRP1(10), SCARB1(3) 6764356 30 26 30 15 12 11 5 0 2 0 0.98 1.00 517 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(2), CASP8(1), CFLAR(1), DAXX(2), DFFB(2), FADD(1), FAF1(1), JUN(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(2) 11532976 48 40 47 12 10 19 6 2 11 0 0.98 1.00 518 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(4), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), HADHA(2), HSD17B12(1), PECR(1), SCD(1) 4036862 16 14 16 4 3 3 4 2 4 0 0.98 1.00 519 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), OCRL(5), PI4KA(4), PI4KB(1), PIK3C3(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), SYNJ1(2), SYNJ2(3) 19558106 113 65 112 34 35 30 21 11 16 0 0.98 1.00 520 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), HBEGF(1), IFNG(1), NR4A3(2), WDR1(1) 2985950 9 9 9 5 1 3 1 2 2 0 0.98 1.00 521 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 137 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(1), AK5(3), AK7(1), AMPD1(4), AMPD2(1), AMPD3(6), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), ENTPD3(1), ENTPD6(3), GART(1), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NME4(1), NME7(2), NPR1(2), NPR2(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(5), PDE11A(8), PDE1A(2), PDE2A(2), PDE3B(3), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6H(2), PDE7B(1), PDE8A(5), PDE8B(2), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRIM1(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RFC5(1), RRM1(1), RRM2B(2), XDH(8) 42874326 211 107 211 85 55 78 40 13 25 0 0.98 1.00 522 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT9(1), GCNT2(1), ST8SIA1(2) 1700256 4 4 4 3 1 1 1 0 1 0 0.98 1.00 523 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP12A(4), ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7B(1), COX4I1(1), COX6B1(1), NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1) 9402494 37 31 37 12 9 8 11 3 6 0 0.98 1.00 524 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25B(1), CDC25C(1), PRKCA(4) 2502858 7 7 7 3 1 3 1 1 1 0 0.98 1.00 525 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF13B(1), TNFSF13(1), TRAF3(1), TRAF5(2), TRAF6(1) 3974740 16 13 16 7 5 3 1 1 6 0 0.98 1.00 526 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(1), CHUK(2), FOS(1), IKBKB(2), IRAK1(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(1), RELA(2), TLR2(3), TLR3(2), TLR7(3), TLR9(1), TOLLIP(1), TRAF6(1) 9458386 40 34 39 12 16 8 6 4 6 0 0.98 1.00 527 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CDC42(1), CREB1(1), DAXX(2), HRAS(1), HSPB2(1), MAP2K6(2), MAP3K1(2), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(5), RAC1(1), RPS6KA5(4), SHC1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1) 9996480 50 37 50 19 12 15 13 5 5 0 0.98 1.00 528 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2) 3689762 14 12 14 5 3 3 3 2 3 0 0.98 1.00 529 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), OGDHL(4), PC(2), PCK1(1), PCK2(1), SDHA(1), SUCLA2(2), SUCLG2(1) 8013026 33 29 33 17 7 11 4 6 5 0 0.98 1.00 530 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(2), ATM(6), BRCA1(6), CHEK1(4), CHEK2(3), GADD45A(1), JUN(3), MAPK8(2), MDM2(1), NFKB1(2), RAD50(2), RAD51(1), RBBP8(1), RELA(2) 7873474 36 28 35 6 6 13 3 8 6 0 0.98 1.00 531 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), NDST1(2), NDST2(1), NDST3(4) 5246906 21 19 21 11 2 10 4 5 0 0 0.98 1.00 532 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(3), ITGB1(3), ITGB3(3), PTK2(4), PXN(3), RAC1(1), SPTAN1(2), TLN1(3) 7784474 36 28 36 17 12 9 4 7 4 0 0.98 1.00 533 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(1), GHR(2), HRAS(1), IGF1(3), PIK3R1(1), SHC1(1), SOD2(1) 3007310 10 9 10 5 2 5 1 2 0 0 0.98 1.00 534 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), AOX1(9), BCKDHB(2), HADHA(2), HADHB(2), HMGCL(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2), SDS(2) 9417980 43 35 43 13 5 18 9 7 4 0 0.98 1.00 535 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), IL22RA2(1), JAK1(1), JAK2(3), JAK3(7), STAT1(2), STAT3(1), STAT5A(2), TYK2(5) 5072466 23 18 23 8 5 10 5 1 2 0 0.98 1.00 536 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), MARS(1), MAT1A(1), PAPSS2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SEPHS1(3), WBSCR22(3) 6761864 28 25 28 9 10 10 2 1 5 0 0.98 1.00 537 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(2), GAB1(2), GADD45A(1), GCK(1), JUN(3), MAP2K5(1), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(2), NR2C2(1), PAPPA(8), SHC1(1), TRAF6(1) 13536722 64 49 63 21 15 24 14 7 4 0 0.99 1.00 538 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(2), DHRS2(1), ESCO1(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1) 8198324 34 29 34 15 8 12 6 2 6 0 0.99 1.00 539 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP3K1(2), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(1), MYC(1), NFKB1(2), PARP1(3), PRF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 10022112 44 33 43 20 10 12 6 8 8 0 0.99 1.00 540 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4) 4817926 17 16 17 6 3 3 8 2 1 0 0.99 1.00 541 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TNFAIP3(3), TRAF3(1), TRAF6(1) 4931312 18 14 18 7 5 2 4 2 5 0 0.99 1.00 542 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25B(1), CDC25C(1), CDK7(1), XPO1(2) 2376300 6 6 6 4 0 2 1 3 0 0 0.99 1.00 543 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), AKT3(2), BRD4(2), CAP1(2), CBL(1), CDC42(1), F2RL2(1), FLOT1(1), GSK3A(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(5), PARD6A(1), PDK1(1), PIK3CD(3), PIK3R1(1), PPYR1(3), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(1), SLC2A4(2), SORBS1(5), SOS1(6), SOS2(5), YWHAB(1), YWHAQ(1) 15227900 78 51 78 19 13 26 20 7 12 0 0.99 1.00 544 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CSF1(2), IL4(2) 1697764 5 4 5 5 1 2 1 0 1 0 0.99 1.00 545 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), HPRT1(1), IMPDH1(1), MTHFD2(3), POLB(1), POLD1(2), POLG(1), PRPS2(1), RRM1(1) 3494318 13 11 13 3 3 5 3 1 1 0 0.99 1.00 546 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GALT6(1), B3GAT1(2), B3GAT2(2), CHPF(1), CHST12(1), CHST3(2), DSE(1), XYLT1(2) 4030810 12 11 12 9 1 4 3 2 2 0 0.99 1.00 547 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX15B(1), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2) 4144552 17 14 17 6 4 9 4 0 0 0 0.99 1.00 548 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SEPHS1(3) 3369540 12 10 12 7 3 6 0 0 3 0 0.99 1.00 549 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(1), FADD(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(2), NSMAF(2), RAF1(1), RELA(2), SMPD1(3), TNFRSF1A(2), TRADD(1) 5630140 24 18 24 10 8 6 5 2 3 0 0.99 1.00 550 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(5), JUN(3), LTA(2), MAP3K1(2), MAPK10(1), MDM2(1), MYC(1), NFKB1(2), NFKBIB(1), PRF1(1), RELA(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TRADD(1), TRAF1(4), TRAF3(1) 15460190 68 47 67 23 13 16 14 10 15 0 0.99 1.00 551 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(1), BCR(1), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), MYC(1), PIK3R1(1), RAF1(1), SOS1(6), STAT1(2), STAT5A(2) 6979024 30 25 29 6 7 8 9 4 2 0 0.99 1.00 552 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(1), CABIN1(1), CAMK1G(2), HDAC5(1), IGF1(3), INSR(7), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NFATC2(4), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYT1(3) 8922784 42 30 42 14 10 13 7 8 4 0 0.99 1.00 553 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(5), CSNK1A1(2), CSNK1A1L(5), CSNK1G1(2), DHH(1), GLI1(1), GLI2(4), GLI3(6), HHIP(1), IHH(1), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(4), PTCH2(5), SMO(1), STK36(2), SUFU(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1) 14282186 65 49 65 29 17 19 12 10 7 0 0.99 1.00 554 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(2), AGPAT3(1), CDS1(2), CHAT(2), CHKA(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), ETNK1(3), GPD1(1), GPD2(2), LYPLA1(3), PAFAH1B1(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB2(5), PLCG1(1), PLCG2(3), PPAP2B(1) 13763316 64 48 64 24 16 24 13 5 6 0 0.99 1.00 555 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(2) 1417058 4 3 4 4 1 2 0 1 0 0 0.99 1.00 556 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12) 4560360 17 15 17 3 4 6 3 3 1 0 0.99 1.00 557 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(2), BRAF(7), CEBPA(1), CHUK(2), CREB1(1), DAXX(2), FOS(1), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(1), MAPK6(2), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MKNK2(1), MYC(1), NFKB1(2), PAK1(1), RAC1(1), RAF1(1), RELA(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(1), SHC1(1), SP1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1) 26589284 122 77 120 42 30 35 26 14 17 0 0.99 1.00 558 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(1), EIF2B5(1), IGF1(3), INPPL1(3), PDK2(1), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1) 4542560 13 13 13 7 0 4 2 3 4 0 0.99 1.00 559 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMB8(2) 2341234 6 6 6 3 2 2 1 0 1 0 0.99 1.00 560 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG13(6), ALG2(2), ALG5(2), ALG6(2), B4GALT1(1), B4GALT3(1), DDOST(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), RPN1(1), ST6GAL1(1), STT3B(1) 11591360 55 39 55 21 18 20 5 6 6 0 0.99 1.00 561 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(3) 1683524 3 3 3 1 2 0 0 1 0 0 0.99 1.00 562 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(6), ATR(12), BRCA1(6), BRCA2(7), CHEK1(4), CHEK2(3), FANCC(2), FANCF(3), FANCG(1), RAD1(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(1), TREX1(1) 11625002 52 39 52 10 11 16 9 8 8 0 0.99 1.00 563 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 MDH1(1), PC(2), PDHA1(2), SLC25A11(1) 2508910 6 6 6 4 0 3 0 2 1 0 0.99 1.00 564 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(2), B3GALT2(2), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2) 13400908 56 44 56 31 14 12 17 6 7 0 0.99 1.00 565 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(8), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ADIPOR2(2), AKT1(1), AKT3(2), CD36(1), CHUK(2), CPT1A(3), CPT1C(3), CPT2(1), G6PC(2), G6PC2(1), IKBKB(2), IRS1(3), IRS2(2), IRS4(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), PCK1(1), PCK2(1), POMC(1), PPARA(1), PPARGC1A(5), PRKAA2(3), PRKAG2(4), PRKAG3(2), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRG(4), SLC2A4(2), STAT3(1), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(5) 22732024 116 71 115 32 37 40 21 7 11 0 0.99 1.00 566 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), CASP9(2), DAXX(2), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(1) 3068186 10 9 10 9 4 2 2 1 1 0 0.99 1.00 567 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), MAP3K14(1), NFKB1(2), RELA(2) 2511402 7 5 7 0 1 1 1 1 3 0 0.99 1.00 568 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(1), ACAT1(1), ADH5(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2) 9689252 39 34 39 19 8 17 5 5 4 0 0.99 1.00 569 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4) 5119102 17 16 17 6 3 3 8 2 1 0 0.99 1.00 570 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(2), ACTN1(2), AKT1(1), AKT3(2), ARHGEF6(2), ARHGEF7(3), BCAR1(5), BRAF(7), CDC42(1), CSE1L(4), DOCK1(3), EPHB2(4), FYN(3), GRLF1(11), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGB3BP(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CB(2), PKLR(3), PLCG1(1), PLCG2(3), PTK2(4), RAF1(1), RALA(2), RHO(1), ROCK1(5), ROCK2(3), SHC1(1), SOS1(6), SOS2(5), TLN1(3), TLN2(11), VASP(2), WAS(4) 32546588 171 92 171 60 38 64 36 9 24 0 1.00 1.00 571 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), EPOR(2), GRIN1(1), HIF1A(1), JAK2(3), NFKB1(2), RELA(2), SOD2(1) 3452132 13 9 13 1 3 3 3 1 3 0 1.00 1.00 572 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(12), CTBP1(1), DLL1(1), DLL3(1), DLL4(1), DTX2(2), DTX3(2), DTX3L(1), DTX4(1), DVL1(3), DVL3(2), EP300(6), HDAC1(2), JAG2(1), LFNG(1), MAML1(2), MAML2(5), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PSEN1(1), PSEN2(2), PSENEN(1), SNW1(2) 19396660 83 62 82 28 21 25 16 6 15 0 1.00 1.00 573 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNE2(2), E2F1(2), PRB1(2) 2268254 6 6 6 1 1 5 0 0 0 0 1.00 1.00 574 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC3(3), CASP8(1), CFLAR(1), FADD(1), JUN(3), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR2C2(1), RALBP1(1), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 7490062 31 23 30 13 6 10 4 7 4 0 1.00 1.00 575 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1) 4289088 16 13 16 8 3 6 3 1 3 0 1.00 1.00 576 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 30 ABAT(2), ACACA(1), ACADL(2), ACADM(1), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), HADHA(2), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), SDS(2), SUCLA2(2), SUCLG2(1) 8608970 30 29 30 11 4 15 5 2 4 0 1.00 1.00 577 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4), PER2(2), PER3(1) 4651140 17 14 17 9 0 8 7 1 1 0 1.00 1.00 578 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(2), ACAA2(1), ACADM(1), ACADS(2), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(9), AUH(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), HADH(1), HADHA(2), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2) 11384524 51 38 51 14 10 16 10 9 6 0 1.00 1.00 579 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BNIP1(1), GOSR1(1), SEC22B(4), SNAP25(1), STX10(1), STX11(1), STX5(2), STX7(1), TSNARE1(1), USE1(1), YKT6(1) 4427750 15 14 15 9 3 5 4 2 1 0 1.00 1.00 580 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), PSPH(1), RDH11(1), RDH12(2), RDH13(1), SARDH(4), SARS(2), SARS2(2), SDS(2), TARS(3), TARS2(2) 11695846 51 38 51 18 12 18 12 4 5 0 1.00 1.00 581 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), XYLT1(2) 1890716 3 3 3 3 0 2 1 0 0 0 1.00 1.00 582 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), XYLT1(2) 1890716 3 3 3 3 0 2 1 0 0 0 1.00 1.00 583 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), PGAP1(3), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2) 6629788 22 19 22 15 4 3 5 6 4 0 1.00 1.00 584 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT3(1), AGPAT6(1), CDS1(2), CHAT(2), CHKA(2), CRLS1(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), ESCO1(1), ETNK1(3), GPAM(2), GPD1(1), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(9), MYST4(3), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLD1(6), PLD2(2), PNPLA3(1), PPAP2B(1), PTDSS1(1), SH3GLB1(1) 18018050 91 58 91 38 21 35 17 7 11 0 1.00 1.00 585 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(1), IDI1(1), MVD(1), SC5DL(1), SQLE(2) 3072458 8 8 8 4 2 3 2 1 0 0 1.00 1.00 586 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), MVD(1), NSDHL(1), SC5DL(1), SQLE(2) 3632980 10 10 10 4 2 4 2 2 0 0 1.00 1.00 587 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(3), EIF2AK3(7), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G3(3), EIF5(1), EIF5B(1), ETF1(1), KIAA0664(1), PABPC1(2), PABPC3(6), PAIP1(1), SLC35A4(1) 12059144 49 41 49 19 9 17 15 3 5 0 1.00 1.00 588 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC2(4), PSMC3(1), PSMD1(2), PSMD11(1), PSMD12(1), PSMD13(1) 4277518 14 13 14 6 5 6 2 0 1 0 1.00 1.00 589 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), APAF1(1), ATM(6), BAX(1), BCL2L1(1), CASP7(2), CASP9(2), PRKCA(4), PTK2(4), PXN(3), STAT1(2), TLN1(3) 7230004 30 23 30 9 9 9 6 4 2 0 1.00 1.00 590 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(1), BCL2L1(1), CBL(1), CFLAR(1), E2F1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), IRS1(3), JAK1(1), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(1), PIK3R1(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1) 9289642 39 30 39 12 7 16 9 3 4 0 1.00 1.00 591 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADSL(1), ADSS(1), AK5(3), AMPD1(4), AMPD2(1), AMPD3(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), GART(1), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NPR1(2), NPR2(2), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6B(3), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1) 33964892 163 92 163 56 40 64 30 12 17 0 1.00 1.00 592 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(1), PLCG2(3), PSPH(1), SARDH(4), SARS(2), TARS(3) 11524254 45 36 45 15 12 15 11 3 4 0 1.00 1.00 593 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CPT1A(3), CPT1C(3), CPT2(1), CYP4A22(2), DCI(1), GCDH(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PECI(1) 13166660 51 43 51 18 11 18 10 8 4 0 1.00 1.00 594 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(2) 3285880 9 8 9 5 2 4 2 1 0 0 1.00 1.00 595 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(3), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS8(1) 6262930 18 18 18 11 4 4 6 3 1 0 1.00 1.00 596 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(2), ACACA(1), ACACB(8), ACADM(1), ACAT1(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), HADHA(2), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), SUCLA2(2), SUCLG2(1) 10380782 38 33 38 15 10 16 4 3 5 0 1.00 1.00 597 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(1), ACACB(8), ACAT1(1), ACOT12(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PCK2(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2) 12317066 51 40 51 25 15 21 5 5 5 0 1.00 1.00 598 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(6), CCNB1(1), CCND2(3), CCND3(1), CCNE2(2), CDK7(1), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MYC(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLE2(2), PRIM1(2), RB1(7), RBL1(5), TFDP2(2), TNXB(15), WEE1(2) 20615604 79 60 79 17 17 29 12 7 14 0 1.00 1.00 599 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSB(1), ARSD(1), ARSE(2), GAL3ST1(1), GALC(1), GLA(2), NEU1(2), NEU2(2), PPAP2B(1), SMPD1(3), SMPD2(1), SPTLC2(3) 5598812 20 16 20 7 6 7 4 2 1 0 1.00 1.00 600 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP4(1), ARHGAP5(1), ARHGAP6(5), ARHGEF1(2), ARHGEF11(7), ARHGEF5(1), ARPC1A(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(1), MYLK(5), OPHN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(4), ROCK1(5), TLN1(3), VCL(2) 12577124 51 40 50 14 8 20 13 7 3 0 1.00 1.00 601 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(8), MCAT(1), OLAH(1), OXSM(1) 4429352 12 11 12 8 6 4 1 0 1 0 1.00 1.00 602 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(2), FDPS(1), GGPS1(2), HSD17B7(1), IDI1(1), IDI2(2), MVD(1), NSDHL(1), SC5DL(1), SQLE(2), TM7SF2(1) 5284998 15 14 15 5 4 5 4 2 0 0 1.00 1.00 603 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(1), ACOT11(1), DHRS2(1), ESCO1(1), GCDH(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1) 6846592 21 18 21 13 4 7 4 1 5 0 1.00 1.00 604 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFB(2), FADD(1), GAS2(2), MAP3K14(1), NFKB1(2), RELA(2), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(1), TRADD(1) 9154184 30 24 30 12 7 8 3 5 7 0 1.00 1.00 605 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BAK1(1), BAX(1), BTK(4), CAD(8), CASP10(3), CASP8(1), CASP8AP2(5), CDK2AP1(1), CSNK1A1(2), DAXX(2), EGFR(6), EPHB2(4), FADD(1), FAF1(1), FAIM2(1), MAP3K1(2), MAP3K5(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MET(3), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR0B2(1), PFN2(1), PTPN13(3), RALBP1(1), ROCK1(5), SMPD1(3), TNFRSF6B(1) 20075552 88 56 87 24 21 31 18 7 11 0 1.00 1.00 606 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(4), ANAPC4(3), ANAPC5(4), CDC27(2), CUL1(2), ITCH(2), RBX1(1), SKP1(1), SKP2(1), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(1) 10101144 32 29 32 9 7 9 5 6 5 0 1.00 1.00 607 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), CDC40(2), CLK2(1), CLK3(1), CLK4(2), COL2A1(8), CPSF1(3), CPSF2(2), CPSF3(1), CPSF4(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(5), DHX15(2), DHX16(1), DHX38(1), DHX8(1), DHX9(5), DICER1(7), FUS(1), METTL3(1), NCBP1(2), NXF1(1), PAPOLA(1), POLR2A(1), PRPF3(1), PRPF4(2), PRPF4B(5), PRPF8(5), PSKH1(1), PTBP2(1), RBM17(1), RBM5(1), RNPS1(1), SF3A1(1), SF3A2(2), SF3A3(2), SF3B1(2), SF3B2(2), SF3B4(1), SF4(2), SFRS12(1), SFRS14(4), SFRS2(2), SFRS6(1), SFRS8(2), SNRPA(2), SNRPB(3), SNRPD1(1), SNRPD2(1), SNRPN(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(2), XRN2(2) 28537138 114 74 112 30 26 32 33 10 13 0 1.00 1.00 608 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AICDA(2), CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), ENTPD3(1), ENTPD6(3), NME4(1), NME7(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PRIM1(2), RFC5(1), RRM1(1), RRM2B(2), TXNRD1(2), TXNRD2(2), UMPS(1), UPP1(3), UPP2(1), UPRT(1) 21837574 89 60 88 35 17 33 18 6 15 0 1.00 1.00 609 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1) 3743518 7 6 7 2 2 1 0 1 3 0 1.00 1.00 610 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(4), CDC7(1), DIAPH2(1), GMNN(2), MCM10(3), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLD1(2), POLD3(1), POLE2(2), PRIM1(2), RFC1(1), RFC4(3), RFC5(1), RPA4(2), UBB(1), UBC(1) 13878660 46 38 46 15 11 13 14 1 7 0 1.00 1.00 611 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(4), POLB(1), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLG(1), POLG2(1), POLI(2), POLK(3), POLL(1), POLQ(12), PRIM1(2), REV1(5), REV3L(3), RFC5(1) 10953230 42 30 42 13 12 10 12 4 4 0 1.00 1.00 612 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), RRM1(1), TXNRD1(2), UMPS(1), UPP1(3) 15680732 60 43 60 12 11 23 11 6 9 0 1.00 1.00 613 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1) 6292478 15 13 15 12 5 4 1 2 3 0 1.00 1.00 614 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(1), GTF2B(1), GTF2E1(1), GTF2H4(1), ILK(1), POLR1A(2), POLR1B(2), POLR2A(1), POLR2B(2), POLR2E(1), POLR3B(2), POLR3D(1), POLR3E(2), POLR3H(1), TAF9(2), TBP(1) 9538486 23 19 23 14 7 4 3 3 6 0 1.00 1.00 615 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(3), ALPP(2), ALPPL2(1), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(1), ERCC3(1), GCH1(1), IFIH1(3), NUDT8(1), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2) 17193732 54 37 54 23 14 21 12 3 4 0 1.00 1.00 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 407442 0 0 0 0 0 0 0 0 0 0 1.00 1.00