Clinical Features Time to Death AGE GENDER RADIATIONS.RADIATION.REGIMENINDICATION NEOADJUVANT.THERAPY nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q PIK3CA 158 (31%) 349 0.85788 1 0.076508 1 1 1 0.51972 1 1 1 TP53 139 (27%) 368 0.78584 1 0.49828 1 0.19536 1 0.43475 1 0.54439 1 GATA3 53 (10%) 454 0.60789 1 0.014897 1 0.48622 1 0.19203 1 0.30243 1 MAP3K1 36 (7%) 471 0.64319 1 5.6851e-05 0.0283 1 1 0.24584 1 0.86114 1 MLL3 29 (6%) 478 0.74651 1 0.021886 1 1 1 0.83127 1 0.33177 1 CDH1 31 (6%) 476 0.90404 1 0.095964 1 1 1 1 1 0.85164 1 MAP2K4 18 (4%) 489 0.10266 1 0.024926 1 1 1 0.42217 1 0.33041 1 PIK3R1 14 (3%) 493 0.21325 1 0.88002 1 1 1 1 1 1 1 PTEN 14 (3%) 493 0.24051 1 0.39243 1 1 1 1 1 0.78676 1 RUNX1 14 (3%) 493 0.17596 1 0.87888 1 1 1 0.76717 1 0.58634 1 TBX3 11 (2%) 496 0.25762 1 0.052314 1 1 1 0.73517 1 0.53792 1 AKT1 12 (2%) 495 0.22284 1 0.5483 1 1 1 0.19406 1 0.76867 1 CTCF 11 (2%) 496 0.16228 1 0.77688 1 1 1 1 1 0.37536 1 NCOR1 15 (3%) 492 0.55751 1 0.32651 1 1 1 0.76945 1 0.2946 1 RPGR 10 (2%) 497 0.78259 1 0.81049 1 1 1 0.73484 1 0.74777 1 RB1 9 (2%) 498 0.69032 1 0.30508 1 1 1 0.45549 1 0.3177 1 CBFB 5 (1%) 502 0.86658 1 0.14027 1 1 1 1 1 0.40907 1 ZFP36L1 6 (1%) 501 0.96755 1 0.16646 1 1 1 0.19536 1 0.40835 1 CDKN1B 5 (1%) 502 0.46922 1 0.98151 1 1 1 1 1 0.40907 1 FOXA1 7 (1%) 500 0.0014003 0.695 0.023111 1 1 1 1 1 0.70507 1 PRRX1 5 (1%) 502 0.50476 1 0.78545 1 1 1 0.12956 1 0.65343 1 MUC4 13 (3%) 494 0.36575 1 0.95761 1 1 1 0.35732 1 0.77977 1 AFF2 11 (2%) 496 0.71591 1 0.018839 1 1 1 0.50321 1 1 1 DSPP 6 (1%) 501 0.2424 1 0.15518 1 1 1 0.6678 1 1 1 ATN1 8 (2%) 499 0.23511 1 0.71983 1 1 1 0.45597 1 0.47926 1 MYB 7 (1%) 500 0.21913 1 0.4854 1 1 1 0.093543 1 0.45579 1 DALRD3 6 (1%) 501 0.6134 1 0.064114 1 1 1 0.35293 1 0.69555 1 GPS2 5 (1%) 502 0.26884 1 0.66766 1 1 1 0.61821 1 1 1 FAM166A 4 (1%) 503 0.96075 1 0.97796 1 1 1 1 1 0.31181 1 NKAIN4 3 (1%) 504 0.59185 1 0.16754 1 1 1 0.020285 1 0.5725 1 PIWIL1 8 (2%) 499 0.18936 1 0.71776 1 1 1 1 1 1 1 SF3B1 10 (2%) 497 0.38609 1 0.37841 1 1 1 1 1 0.53424 1 SAAL1 5 (1%) 502 0.20177 1 0.8191 1 1 1 0.61821 1 1 1 TMEM82 4 (1%) 503 1 1 0.26911 1 1 1 0.57909 1 0.14571 1 HIST1H2BC 4 (1%) 503 0.55588 1 0.65737 1 1 1 1 1 0.31181 1 TBL1XR1 5 (1%) 502 0.0033664 1 0.25651 1 1 1 1 1 0.40907 1 WNT7A 5 (1%) 502 0.60039 1 0.93802 1 1 1 0.61821 1 0.65343 1 BID 4 (1%) 503 0.17474 1 0.036755 1 1 1 0.30277 1 0.31181 1 LRFN4 4 (1%) 503 0.15872 1 0.75798 1 1 1 0.57909 1 0.31181 1 TLE6 6 (1%) 501 0.26403 1 0.48793 1 1 1 1 1 1 1 FER1L5 7 (1%) 500 0.75223 1 0.021688 1 1 1 0.39892 1 0.022056 1 HIST1H1C 4 (1%) 503 0.76641 1 0.97902 1 0.046639 1 0.57909 1 1 1 GPR32 5 (1%) 502 0.73272 1 0.15534 1 1 1 1 1 1 1 MLLT4 7 (1%) 500 0.072404 1 0.30584 1 1 1 0.67973 1 0.70507 1 ITPKB 7 (1%) 500 0.48854 1 0.024672 1 1 1 0.19802 1 1 1 COL18A1 6 (1%) 501 0.52447 1 0.18967 1 1 1 0.6678 1 0.69555 1 CCR2 4 (1%) 503 0.8497 1 0.37982 1 1 1 1 1 1 1 HAUS5 6 (1%) 501 0.6702 1 0.97756 1 1 1 0.19536 1 1 1 MUC5B 12 (2%) 495 0.025096 1 0.95443 1 1 1 1 1 0.56514 1 LLGL2 5 (1%) 502 0.44506 1 0.036038 1 1 1 0.61821 1 1 1 PYCRL 3 (1%) 504 0 0 0.63317 1 1 1 1 1 1 1 CIRBP 3 (1%) 504 0.61931 1 0.096039 1 1 1 1 1 1 1 GPRIN2 4 (1%) 503 0.2082 1 0.26014 1 1 1 1 1 0.31181 1 KLRG2 3 (1%) 504 NA NA 0.30675 1 1 1 0.18375 1 0.5725 1 PQLC2 4 (1%) 503 0.28294 1 0.046777 1 1 1 0.57909 1 0.64544 1 GLI4 3 (1%) 504 0.47489 1 0.57441 1 1 1 0.56529 1 1 1 HLA-A 4 (1%) 503 0.21014 1 0.44873 1 1 1 0.30277 1 1 1 UBC 6 (1%) 501 0.32346 1 0.73565 1 1 1 0.6678 1 0.23762 1 MYT1L 8 (2%) 499 0.88762 1 0.73569 1 1 1 0.22362 1 0.72347 1 PIP4K2C 5 (1%) 502 0.14895 1 0.75857 1 1 1 0.61821 1 1 1 PPEF1 6 (1%) 501 0.53049 1 0.58802 1 1 1 1 1 1 1 KCNQ2 4 (1%) 503 0.41 1 0.92304 1 1 1 0.57909 1 0.14571 1 LYSMD3 4 (1%) 503 0.73622 1 0.57954 1 1 1 1 1 0.64544 1 NF1 12 (2%) 495 0.518 1 0.64637 1 1 1 0.19406 1 0.76867 1 ARID1A 8 (2%) 499 0.97452 1 0.50667 1 1 1 0.45597 1 0.14827 1 ATP10B 10 (2%) 497 0.64984 1 0.28595 1 1 1 0.73484 1 1 1 GRIN2A 9 (2%) 498 0.31963 1 0.73342 1 1 1 0.45549 1 0.3177 1 MED23 8 (2%) 499 0.45956 1 0.021325 1 1 1 0.68998 1 0.72347 1 FLG 16 (3%) 491 0.5258 1 0.34458 1 1 1 0.77694 1 0.80255 1 FMN2 7 (1%) 500 0.75403 1 0.10267 1 1 1 0.67973 1 0.45579 1 KIAA1644 3 (1%) 504 0.18594 1 0.84952 1 1 1 0.56529 1 1 1 PRND 3 (1%) 504 0.73696 1 0.78484 1 1 1 1 1 0.5725 1 SPTA1 12 (2%) 495 0.04576 1 0.34212 1 1 1 0.19406 1 0.37502 1 CHST2 3 (1%) 504 0.64692 1 0.45159 1 1 1 0.020285 1 0.070466 1 RGS7 5 (1%) 502 0.6945 1 0.71016 1 1 1 0.61821 1 0.65343 1 CCDC146 5 (1%) 502 0.64096 1 0.56414 1 1 1 0.61821 1 0.65343 1 OPRM1 5 (1%) 502 0.49204 1 0.27597 1 1 1 1 1 0.40907 1 PCDHA8 6 (1%) 501 0.0055536 1 0.94403 1 1 1 0.19536 1 1 1 PIP5K1C 3 (1%) 504 0.6833 1 0.48662 1 1 1 1 1 1 1 CCND3 3 (1%) 504 0.50179 1 0.14686 1 1 1 1 1 0.5725 1 CCT6B 5 (1%) 502 0.16664 1 0.99988 1 0.058011 1 1 1 1 1 OBSCN 17 (3%) 490 0.36542 1 0.36794 1 1 1 1 1 0.33041 1 TPO 6 (1%) 501 0.40604 1 0.18733 1 1 1 0.6678 1 1 1 SELL 4 (1%) 503 0.60191 1 0.71715 1 1 1 1 1 0.64544 1 CCDC88B 5 (1%) 502 0.68114 1 0.082935 1 1 1 0.12956 1 0.65343 1 SARM1 3 (1%) 504 0.56974 1 0.77148 1 1 1 0.56529 1 1 1 SPEN 13 (3%) 494 0.097772 1 0.11257 1 1 1 0.35732 1 1 1 EPS8L1 4 (1%) 503 0.24789 1 0.17539 1 1 1 1 1 0.64544 1 ZP4 5 (1%) 502 0.5152 1 0.13928 1 1 1 1 1 1 1 C19ORF39 3 (1%) 504 0.21627 1 0.10599 1 1 1 1 1 0.5725 1 CCDC159 3 (1%) 504 0.39492 1 0.34122 1 0.035153 1 0.56529 1 1 1 H2BFWT 3 (1%) 504 NA NA 0.58898 1 1 1 1 1 0.5725 1 PHLDA1 3 (1%) 504 0.94489 1 0.45124 1 1 1 0.56529 1 1 1 MEFV 6 (1%) 501 0.54513 1 0.020864 1 0.06927 1 1 1 0.40835 1 NEK5 6 (1%) 501 0.50706 1 0.099751 1 1 1 1 1 1 1 KCNT2 8 (2%) 499 0.69497 1 0.37167 1 1 1 0.45597 1 0.47926 1 LIF 3 (1%) 504 0.55712 1 0.55508 1 1 1 0.56529 1 1 1 PRAME 5 (1%) 502 0.76285 1 0.756 1 1 1 0.61821 1 1 1 C1ORF65 4 (1%) 503 0.17635 1 0.91028 1 1 1 0.30277 1 1 1 LPO 5 (1%) 502 0.57085 1 0.021971 1 1 1 0.61821 1 0.65343 1