Glioblastoma Multiforme: Correlation between gene mutation status and selected clinical features

Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)

Overview

Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 419 genes and 7 clinical features across 269 patients, 48 significant findings detected with Q value < 0.25.

IDH1 mutation correlated to 'AGE'.
OR5W2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
C21ORF58 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ZNF704 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CDKN2C mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
SPAM1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ZNF784 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
MSLNL mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
NFKBIL2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
RBM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
MAGEC2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CCDC114 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CHEK1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ARID3B mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
PUF60 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
DPEP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
SPIRE2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CTDSP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
TLR6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
N4BP3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
GJB1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
LEFTY1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ANGPT4 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
FBXO31 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
OTUD6A mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
MC3R mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
C9ORF86 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
HOXD13 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
TGM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
JAG2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CHP2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
HNRNPCL1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
FOXF1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
JHDM1D mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
LMO1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
PRKRIP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
SLC39A4 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ZNF599 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
TNFSF10 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
CXCL6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
PSG7 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
SLITRK6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
MPP7 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
GUCY1A3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
ANO5 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
C12ORF50 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
FGG mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.
SH3GLB2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between mutation status of 419 genes and 7 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 48 significant findings detected.


		Clinical Features	Time to Death	AGE	GENDER	KARNOFSKY PERFORMANCE SCORE	HISTOLOGICAL TYPE	RADIATIONS RADIATION REGIMENINDICATION	NEOADJUVANT THERAPY
	nMutated (%)	nWild-Type	logrank test	t-test	Fisher's exact test	t-test	Fisher's exact test	Fisher's exact test	Fisher's exact test
IDH1	15 (6%)	254	0.00425 (1.00)	2.36e-05 (0.068)	1 (1.00)	0.00152 (1.00)	1 (1.00)	0.00357 (1.00)	0.402 (1.00)
OR5W2	6 (2%)	263	0.234 (1.00)	0.129 (1.00)	0.67 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
C21ORF58	5 (2%)	264	0.602 (1.00)	0.257 (1.00)	0.355 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.0359 (1.00)	0.0359 (1.00)
ZNF704	5 (2%)	264	0.511 (1.00)	0.875 (1.00)	0.657 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.183 (1.00)	0.183 (1.00)
CDKN2C	4 (1%)	265	0.631 (1.00)	0.331 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	0.593 (1.00)
SPAM1	6 (2%)	263	0.577 (1.00)	0.358 (1.00)	0.67 (1.00)	3.01e-05 (0.0868)	1 (1.00)	0.668 (1.00)	0.181 (1.00)
ZNF784	3 (1%)	266	0.344 (1.00)	0.719 (1.00)	0.555 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
MSLNL	6 (2%)	263	0.677 (1.00)	0.725 (1.00)	0.424 (1.00)	3.02e-05 (0.0869)	0.0657 (1.00)	0.668 (1.00)	1 (1.00)
NFKBIL2	6 (2%)	263	0.916 (1.00)	0.309 (1.00)	0.67 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.181 (1.00)	0.181 (1.00)
RBM3	3 (1%)	266	0.226 (1.00)	0.803 (1.00)	0.296 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.236 (1.00)	0.236 (1.00)
MAGEC2	5 (2%)	264	0.859 (1.00)	0.399 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
CCDC114	6 (2%)	263	0.487 (1.00)	0.297 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	0.0815 (1.00)
CHEK1	5 (2%)	264	0.473 (1.00)	0.129 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.653 (1.00)	1 (1.00)
ARID3B	5 (2%)	264	0.879 (1.00)	0.13 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.183 (1.00)	0.0359 (1.00)
PUF60	4 (1%)	265	0.502 (1.00)	0.0718 (1.00)	0.3 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.0947 (1.00)	0.0947 (1.00)
DPEP1	3 (1%)	266	0.0195 (1.00)	0.784 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
SPIRE2	4 (1%)	265	0.997 (1.00)	0.000267 (0.755)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
CTDSP1	4 (1%)	265	0.526 (1.00)	0.266 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	0.0947 (1.00)
TLR6	6 (2%)	263	0.918 (1.00)	0.757 (1.00)	0.0243 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.384 (1.00)	0.384 (1.00)
N4BP3	5 (2%)	264	0.653 (1.00)	0.701 (1.00)	0.657 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.653 (1.00)	0.183 (1.00)
GJB1	4 (1%)	265	0.374 (1.00)	0.436 (1.00)	0.135 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
LEFTY1	4 (1%)	265	0.497 (1.00)	0.177 (1.00)	0.135 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.593 (1.00)	1 (1.00)
ANGPT4	5 (2%)	264	0.386 (1.00)	0.248 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
FBXO31	5 (2%)	264	0.927 (1.00)	0.259 (1.00)	0.0584 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.33 (1.00)	1 (1.00)
OTUD6A	4 (1%)	265	0.569 (1.00)	0.241 (1.00)	0.135 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	0.311 (1.00)
MC3R	4 (1%)	265	0.629 (1.00)	0.678 (1.00)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	0.593 (1.00)
C9ORF86	4 (1%)	265	0.39 (1.00)	0.373 (1.00)	0.135 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.311 (1.00)	1 (1.00)
HOXD13	4 (1%)	265	0.735 (1.00)	0.412 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
TGM3	7 (3%)	262	0.589 (1.00)	0.639 (1.00)	0.00978 (1.00)	3.02e-05 (0.0869)	1 (1.00)	0.212 (1.00)	1 (1.00)
JAG2	4 (1%)	265	0.38 (1.00)	0.502 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.593 (1.00)	1 (1.00)
CHP2	4 (1%)	265	0.168 (1.00)	0.792 (1.00)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
HNRNPCL1	4 (1%)	265	0.717 (1.00)	0.427 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	0.311 (1.00)
FOXF1	3 (1%)	266	0.775 (1.00)	0.879 (1.00)	0.555 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
JHDM1D	6 (2%)	263	0.0963 (1.00)	0.561 (1.00)	0.193 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.384 (1.00)	0.0815 (1.00)
LMO1	3 (1%)	266	0.588 (1.00)	0.53 (1.00)	0.046 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
PRKRIP1	3 (1%)	266	0.997 (1.00)	0.567 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.554 (1.00)	1 (1.00)
SLC39A4	4 (1%)	265	0.956 (1.00)	0.127 (1.00)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
ZNF599	5 (2%)	264	0.671 (1.00)	0.625 (1.00)	0.355 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.183 (1.00)	0.183 (1.00)
TNFSF10	4 (1%)	265	0.842 (1.00)	0.612 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.0947 (1.00)	0.0947 (1.00)
CXCL6	3 (1%)	266	0.85 (1.00)	0.704 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.236 (1.00)	0.236 (1.00)
PSG7	4 (1%)	265	0.279 (1.00)	0.907 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
SLITRK6	5 (2%)	264	0.102 (1.00)	0.911 (1.00)	0.657 (1.00)	6.76e-34 (1.95e-30)	1 (1.00)	1 (1.00)	0.653 (1.00)
MPP7	4 (1%)	265	0.561 (1.00)	0.129 (1.00)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
GUCY1A3	5 (2%)	264	0.339 (1.00)	0.365 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	1 (1.00)
ANO5	6 (2%)	263	0.211 (1.00)	0.939 (1.00)	1 (1.00)	3.02e-05 (0.0869)	1 (1.00)	1 (1.00)	0.384 (1.00)
C12ORF50	4 (1%)	265	0.157 (1.00)	0.522 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	1 (1.00)	0.311 (1.00)
FGG	4 (1%)	265	0.113 (1.00)	0.649 (1.00)	0.621 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.593 (1.00)	0.593 (1.00)
SH3GLB2	4 (1%)	265	0.445 (1.00)	0.105 (1.00)	1 (1.00)	3.03e-05 (0.0869)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
TP53	80 (30%)	189	0.109 (1.00)	0.769 (1.00)	0.166 (1.00)	0.49 (1.00)	0.557 (1.00)	0.391 (1.00)	0.568 (1.00)
EGFR	53 (20%)	216	0.887 (1.00)	0.61 (1.00)	0.752 (1.00)	0.825 (1.00)	0.484 (1.00)	1 (1.00)	1 (1.00)
KRTAP5-5	16 (6%)	253	0.0204 (1.00)	0.633 (1.00)	1 (1.00)	0.485 (1.00)	1 (1.00)	0.281 (1.00)	0.281 (1.00)
NF1	24 (9%)	245	0.381 (1.00)	0.359 (1.00)	0.828 (1.00)	0.443 (1.00)	1 (1.00)	0.499 (1.00)	1 (1.00)
PIK3CA	19 (7%)	250	0.203 (1.00)	0.752 (1.00)	0.325 (1.00)	0.0193 (1.00)	1 (1.00)	0.799 (1.00)	1 (1.00)
PIK3R1	17 (6%)	252	0.702 (1.00)	0.848 (1.00)	1 (1.00)	0.682 (1.00)	1 (1.00)	0.422 (1.00)	0.789 (1.00)
PTEN	77 (29%)	192	0.619 (1.00)	0.0694 (1.00)	1 (1.00)	0.0373 (1.00)	1 (1.00)	0.47 (1.00)	0.47 (1.00)
RB1	20 (7%)	249	0.371 (1.00)	0.863 (1.00)	0.34 (1.00)	0.408 (1.00)	1 (1.00)	1 (1.00)	0.321 (1.00)
SPTA1	26 (10%)	243	0.152 (1.00)	0.873 (1.00)	0.522 (1.00)	0.782 (1.00)	1 (1.00)	1 (1.00)	0.825 (1.00)
MICALCL	12 (4%)	257	0.272 (1.00)	0.699 (1.00)	0.546 (1.00)	0.0089 (1.00)	1 (1.00)	1 (1.00)	0.758 (1.00)
RYR2	28 (10%)	241	0.606 (1.00)	0.614 (1.00)	0.144 (1.00)	0.257 (1.00)	0.282 (1.00)	0.199 (1.00)	0.832 (1.00)
FLG	27 (10%)	242	0.908 (1.00)	0.875 (1.00)	1 (1.00)	0.901 (1.00)	1 (1.00)	0.519 (1.00)	0.83 (1.00)
FOXRED1	9 (3%)	260	0.973 (1.00)	0.338 (1.00)	0.075 (1.00)	0.415 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
MUC2	15 (6%)	254	0.277 (1.00)	0.584 (1.00)	0.785 (1.00)	0.221 (1.00)	1 (1.00)	0.156 (1.00)	0.402 (1.00)
MST1	9 (3%)	260	0.364 (1.00)	0.776 (1.00)	0.727 (1.00)	0.266 (1.00)	1 (1.00)	0.47 (1.00)	1 (1.00)
HEATR7B2	12 (4%)	257	0.291 (1.00)	0.84 (1.00)	1 (1.00)	0.267 (1.00)	1 (1.00)	0.527 (1.00)	1 (1.00)
KEL	12 (4%)	257	0.5 (1.00)	0.444 (1.00)	0.361 (1.00)	0.0131 (1.00)	1 (1.00)	1 (1.00)	0.758 (1.00)
GABRA6	9 (3%)	260	0.123 (1.00)	0.341 (1.00)	0.727 (1.00)	0.748 (1.00)	1 (1.00)	1 (1.00)	0.724 (1.00)
STAG2	10 (4%)	259	0.676 (1.00)	0.144 (1.00)	0.176 (1.00)	0.0293 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
COMMD4	5 (2%)	264	0.0397 (1.00)	0.85 (1.00)	0.163 (1.00)	0.959 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
CRYBA2	6 (2%)	263	0.0639 (1.00)	0.0518 (1.00)	0.67 (1.00)	0.739 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
RIMS2	14 (5%)	255	0.492 (1.00)	0.322 (1.00)	0.391 (1.00)	0.0145 (1.00)	0.149 (1.00)	0.559 (1.00)	0.237 (1.00)
CALN1	9 (3%)	260	0.0625 (1.00)	0.979 (1.00)	0.727 (1.00)	0.234 (1.00)	1 (1.00)	0.724 (1.00)	0.28 (1.00)
IL17RA	8 (3%)	261	0.695 (1.00)	0.182 (1.00)	0.715 (1.00)	0.493 (1.00)	0.0869 (1.00)	1 (1.00)	0.442 (1.00)
CNTNAP2	14 (5%)	255	0.929 (1.00)	0.421 (1.00)	0.58 (1.00)	0.0905 (1.00)	0.149 (1.00)	0.237 (1.00)	1 (1.00)
POTEB	9 (3%)	260	0.577 (1.00)	0.803 (1.00)	1 (1.00)	0.971 (1.00)	1 (1.00)	0.47 (1.00)	0.47 (1.00)
HCN1	10 (4%)	259	0.0208 (1.00)	0.13 (1.00)	0.0387 (1.00)	0.346 (1.00)	1 (1.00)	0.0128 (1.00)	0.0773 (1.00)
CDH18	10 (4%)	259	0.0408 (1.00)	0.782 (1.00)	0.503 (1.00)	0.773 (1.00)	1 (1.00)	0.73 (1.00)	0.296 (1.00)
DNASE1L1	6 (2%)	263	0.822 (1.00)	0.576 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.384 (1.00)
CEACAM16	7 (3%)	262	0.823 (1.00)	0.268 (1.00)	0.257 (1.00)	0.296 (1.00)	1 (1.00)	1 (1.00)	0.682 (1.00)
C9ORF150	6 (2%)	263	0.694 (1.00)	0.144 (1.00)	1 (1.00)	0.023 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
FAM83H	10 (4%)	259	0.877 (1.00)	0.825 (1.00)	0.503 (1.00)	0.115 (1.00)	1 (1.00)	0.73 (1.00)	0.512 (1.00)
OR5D13	7 (3%)	262	0.306 (1.00)	0.885 (1.00)	0.102 (1.00)	0.0399 (1.00)	0.0763 (1.00)	0.438 (1.00)	0.438 (1.00)
SLCO6A1	10 (4%)	259	0.785 (1.00)	0.671 (1.00)	1 (1.00)	0.355 (1.00)	1 (1.00)	0.178 (1.00)	0.178 (1.00)
FBLN2	9 (3%)	260	0.958 (1.00)	0.344 (1.00)	1 (1.00)	0.308 (1.00)	1 (1.00)	0.28 (1.00)	0.724 (1.00)
PCLO	18 (7%)	251	0.224 (1.00)	0.998 (1.00)	0.455 (1.00)	0.156 (1.00)	1 (1.00)	1 (1.00)	0.799 (1.00)
ADRA2B	6 (2%)	263	0.486 (1.00)	0.636 (1.00)	0.67 (1.00)	0.45 (1.00)	0.0657 (1.00)	0.668 (1.00)	0.384 (1.00)
PLA2G2A	5 (2%)	264	0.0228 (1.00)	0.0212 (1.00)	0.657 (1.00)	0.346 (1.00)	1 (1.00)	0.0359 (1.00)	0.0359 (1.00)
CC2D1A	9 (3%)	260	0.998 (1.00)	0.845 (1.00)	1 (1.00)	0.328 (1.00)	1 (1.00)	0.724 (1.00)	0.47 (1.00)
ADAM29	9 (3%)	260	0.795 (1.00)	0.136 (1.00)	0.163 (1.00)	0.757 (1.00)	1 (1.00)	0.724 (1.00)	0.724 (1.00)
SEMG1	8 (3%)	261	0.682 (1.00)	0.78 (1.00)	0.465 (1.00)	0.146 (1.00)	1 (1.00)	0.267 (1.00)	0.114 (1.00)
SUSD3	6 (2%)	263	0.887 (1.00)	0.0668 (1.00)	1 (1.00)	0.903 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
BBS1	8 (3%)	261	0.954 (1.00)	0.0348 (1.00)	1 (1.00)	0.0597 (1.00)	1 (1.00)	0.711 (1.00)	1 (1.00)
FUT7	5 (2%)	264	0.887 (1.00)	0.157 (1.00)	0.163 (1.00)	0.438 (1.00)	1 (1.00)	0.653 (1.00)	0.0029 (1.00)
EML2	8 (3%)	261	0.283 (1.00)	0.363 (1.00)	1 (1.00)	0.222 (1.00)	1 (1.00)	0.267 (1.00)	0.711 (1.00)
HMP19	5 (2%)	264	0.901 (1.00)	0.562 (1.00)	0.657 (1.00)	0.776 (1.00)	1 (1.00)	0.183 (1.00)	0.653 (1.00)
SEMA3C	8 (3%)	261	0.0409 (1.00)	0.902 (1.00)	0.715 (1.00)	0.805 (1.00)	1 (1.00)	0.267 (1.00)	0.267 (1.00)
ACSM4	7 (3%)	262	0.0785 (1.00)	0.417 (1.00)	0.257 (1.00)	0.415 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
MAGEB1	6 (2%)	263	0.289 (1.00)	0.153 (1.00)	1 (1.00)	0.508 (1.00)	1 (1.00)	0.668 (1.00)	0.181 (1.00)
CDH9	9 (3%)	260	0.365 (1.00)	0.123 (1.00)	0.727 (1.00)	0.653 (1.00)	1 (1.00)	0.724 (1.00)	0.47 (1.00)
ZFP42	7 (3%)	262	0.516 (1.00)	0.68 (1.00)	0.257 (1.00)	0.508 (1.00)	1 (1.00)	1 (1.00)	0.682 (1.00)
ADAMTS16	10 (4%)	259	0.0593 (1.00)	0.763 (1.00)	0.503 (1.00)	0.0403 (1.00)	1 (1.00)	0.512 (1.00)	0.73 (1.00)
GABRB2	7 (3%)	262	0.213 (1.00)	0.00863 (1.00)	0.257 (1.00)	0.45 (1.00)	1 (1.00)	0.212 (1.00)	0.682 (1.00)
TRAT1	5 (2%)	264	0.6 (1.00)	0.658 (1.00)	1 (1.00)	0.407 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
TMEM45A	5 (2%)	264	0.165 (1.00)	0.776 (1.00)	0.355 (1.00)	0.929 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
LRRC55	6 (2%)	263	0.728 (1.00)	0.278 (1.00)	1 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
DND1	4 (1%)	265	0.744 (1.00)	0.145 (1.00)	0.621 (1.00)	0.528 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
DNMT3L	6 (2%)	263	0.988 (1.00)	0.515 (1.00)	0.0905 (1.00)	0.947 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
GABRA1	7 (3%)	262	0.724 (1.00)	0.307 (1.00)	1 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
MUC16	33 (12%)	236	0.287 (1.00)	0.74 (1.00)	0.442 (1.00)	0.731 (1.00)	0.326 (1.00)	1 (1.00)	0.691 (1.00)
POM121L12	7 (3%)	262	0.661 (1.00)	0.379 (1.00)	0.102 (1.00)	0.513 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
SCN9A	11 (4%)	258	0.259 (1.00)	0.84 (1.00)	0.751 (1.00)	0.888 (1.00)	1 (1.00)	0.332 (1.00)	1 (1.00)
PRIM2	5 (2%)	264	0.484 (1.00)	0.53 (1.00)	0.0584 (1.00)		1 (1.00)	0.183 (1.00)	0.183 (1.00)
ANO2	9 (3%)	260	0.0902 (1.00)	0.302 (1.00)	0.727 (1.00)	0.35 (1.00)	1 (1.00)	0.0304 (1.00)	0.47 (1.00)
OR52M1	6 (2%)	263	0.537 (1.00)	0.0862 (1.00)	0.67 (1.00)	0.638 (1.00)	1 (1.00)	0.181 (1.00)	0.181 (1.00)
LPHN1	10 (4%)	259	0.337 (1.00)	0.0921 (1.00)	1 (1.00)	0.00369 (1.00)	1 (1.00)	0.512 (1.00)	0.512 (1.00)
KLHL34	6 (2%)	263	0.92 (1.00)	0.812 (1.00)	0.193 (1.00)	0.631 (1.00)	1 (1.00)	1 (1.00)	0.384 (1.00)
OR5AR1	4 (1%)	265	0.395 (1.00)	0.0254 (1.00)	0.621 (1.00)	0.12 (1.00)	1 (1.00)	0.593 (1.00)	0.311 (1.00)
FAM132A	4 (1%)	265	0.356 (1.00)	0.19 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
NAPRT1	4 (1%)	265	0.395 (1.00)	0.517 (1.00)	1 (1.00)	0.146 (1.00)	1 (1.00)	0.593 (1.00)	1 (1.00)
TRHDE	8 (3%)	261	0.573 (1.00)	0.972 (1.00)	0.465 (1.00)	0.631 (1.00)	1 (1.00)	1 (1.00)	0.711 (1.00)
COL6A3	17 (6%)	252	0.193 (1.00)	0.236 (1.00)	0.795 (1.00)	0.354 (1.00)	1 (1.00)	0.789 (1.00)	0.789 (1.00)
ARHGAP9	7 (3%)	262	0.525 (1.00)	0.932 (1.00)	1 (1.00)	0.0806 (1.00)	1 (1.00)	0.682 (1.00)	0.212 (1.00)
ZNF208	8 (3%)	261	0.612 (1.00)	0.26 (1.00)	0.0276 (1.00)	0.163 (1.00)	1 (1.00)	0.267 (1.00)	0.711 (1.00)
DUS3L	7 (3%)	262	0.687 (1.00)	0.783 (1.00)	1 (1.00)	0.379 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
TMEM155	3 (1%)	266	0.262 (1.00)	0.65 (1.00)	1 (1.00)	0.73 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
NRBP2	4 (1%)	265	0.144 (1.00)	0.977 (1.00)	0.3 (1.00)	0.576 (1.00)	1 (1.00)	0.311 (1.00)	0.593 (1.00)
SMR3B	3 (1%)	266	0.237 (1.00)	0.224 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
KDSR	5 (2%)	264	0.447 (1.00)	0.245 (1.00)	0.657 (1.00)	0.386 (1.00)	1 (1.00)	0.183 (1.00)	0.653 (1.00)
SLC27A2	7 (3%)	262	0.466 (1.00)	0.43 (1.00)	1 (1.00)	0.903 (1.00)	1 (1.00)	0.438 (1.00)	0.438 (1.00)
PRDM9	8 (3%)	261	0.49 (1.00)	0.695 (1.00)	0.465 (1.00)	0.929 (1.00)	0.0869 (1.00)	0.711 (1.00)	0.267 (1.00)
TMEM132D	10 (4%)	259	0.379 (1.00)	0.902 (1.00)	0.00516 (1.00)	0.59 (1.00)	1 (1.00)	0.296 (1.00)	1 (1.00)
MAGEB4	5 (2%)	264	0.159 (1.00)	0.309 (1.00)	0.0584 (1.00)	0.0938 (1.00)	1 (1.00)	0.653 (1.00)	0.33 (1.00)
OBSCN	23 (9%)	246	0.231 (1.00)	0.889 (1.00)	0.113 (1.00)	0.264 (1.00)	0.02 (1.00)	0.645 (1.00)	0.645 (1.00)
TTN	61 (23%)	208	0.379 (1.00)	0.824 (1.00)	0.764 (1.00)	0.0308 (1.00)	1 (1.00)	0.755 (1.00)	0.274 (1.00)
DOCK5	11 (4%)	258	0.478 (1.00)	0.476 (1.00)	1 (1.00)	0.888 (1.00)	0.118 (1.00)	0.332 (1.00)	0.746 (1.00)
CXORF22	8 (3%)	261	0.0287 (1.00)	0.594 (1.00)	1 (1.00)	0.266 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR51A2	3 (1%)	266	0.307 (1.00)	0.0742 (1.00)	0.555 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
DPPA4	5 (2%)	264	0.354 (1.00)	0.35 (1.00)	0.657 (1.00)	0.903 (1.00)	1 (1.00)	0.653 (1.00)	1 (1.00)
PLEKHG4B	9 (3%)	260	0.733 (1.00)	0.866 (1.00)	0.291 (1.00)	0.59 (1.00)	1 (1.00)	0.147 (1.00)	0.47 (1.00)
FLG2	11 (4%)	258	0.212 (1.00)	0.224 (1.00)	0.337 (1.00)	0.65 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
IRF5	5 (2%)	264	0.244 (1.00)	0.611 (1.00)	0.657 (1.00)	0.229 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR8K3	4 (1%)	265	0.742 (1.00)	0.711 (1.00)	0.621 (1.00)	0.146 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
ZMYM3	10 (4%)	259	0.463 (1.00)	0.0702 (1.00)	1 (1.00)	0.00888 (1.00)	1 (1.00)	0.512 (1.00)	0.512 (1.00)
C22ORF32	4 (1%)	265	0.571 (1.00)	0.701 (1.00)	0.621 (1.00)	0.572 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
KRT23	6 (2%)	263	0.244 (1.00)	0.0952 (1.00)	0.0243 (1.00)	0.756 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
LRFN5	7 (3%)	262	0.714 (1.00)	0.831 (1.00)	0.257 (1.00)	0.959 (1.00)	1 (1.00)	0.212 (1.00)	0.682 (1.00)
PRMT6	5 (2%)	264	0.0871 (1.00)	0.309 (1.00)	1 (1.00)		1 (1.00)	0.183 (1.00)	1 (1.00)
DDX11	6 (2%)	263	0.193 (1.00)	0.635 (1.00)	0.67 (1.00)	0.614 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
QKI	5 (2%)	264	0.782 (1.00)	0.669 (1.00)	1 (1.00)	0.882 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
PRDM12	4 (1%)	265	0.825 (1.00)	0.423 (1.00)	1 (1.00)		1 (1.00)	0.593 (1.00)	0.593 (1.00)
LGSN	6 (2%)	263	0.208 (1.00)	0.924 (1.00)	0.67 (1.00)	0.234 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
TRIML1	7 (3%)	262	0.699 (1.00)	0.317 (1.00)	0.102 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
TPTE	6 (2%)	263	0.167 (1.00)	0.387 (1.00)	1 (1.00)	0.576 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
BID	4 (1%)	265	0.00297 (1.00)	0.888 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.0947 (1.00)	0.593 (1.00)
FOXC1	4 (1%)	265	0.214 (1.00)	0.633 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
TRPM2	10 (4%)	259	0.602 (1.00)	0.552 (1.00)	0.751 (1.00)	0.509 (1.00)	0.108 (1.00)	0.178 (1.00)	1 (1.00)
C7ORF52	6 (2%)	263	0.493 (1.00)	0.382 (1.00)	1 (1.00)	0.49 (1.00)	1 (1.00)	0.668 (1.00)	0.384 (1.00)
SULT1B1	4 (1%)	265	0.48 (1.00)	0.616 (1.00)	0.621 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
TPTE2	6 (2%)	263	0.322 (1.00)	0.796 (1.00)	0.67 (1.00)	0.415 (1.00)	1 (1.00)	0.0815 (1.00)	0.384 (1.00)
ECEL1	6 (2%)	263	0.426 (1.00)	0.375 (1.00)	0.67 (1.00)	0.513 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
KPRP	7 (3%)	262	0.688 (1.00)	0.144 (1.00)	0.257 (1.00)	0.508 (1.00)	1 (1.00)	1 (1.00)	0.682 (1.00)
UGT2B28	5 (2%)	264	0.592 (1.00)	0.583 (1.00)	0.657 (1.00)	0.576 (1.00)	1 (1.00)	0.653 (1.00)	0.183 (1.00)
HYDIN	23 (9%)	246	0.494 (1.00)	0.543 (1.00)	0.498 (1.00)	0.175 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
MEGF8	10 (4%)	259	0.796 (1.00)	0.141 (1.00)	0.503 (1.00)	0.664 (1.00)	1 (1.00)	0.0336 (1.00)	0.178 (1.00)
SLC6A3	8 (3%)	261	0.137 (1.00)	0.97 (1.00)	1 (1.00)	0.631 (1.00)	1 (1.00)	0.711 (1.00)	0.442 (1.00)
CALCR	6 (2%)	263	0.597 (1.00)	0.54 (1.00)	1 (1.00)	0.959 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
FTMT	5 (2%)	264	0.812 (1.00)	0.66 (1.00)	0.355 (1.00)	0.929 (1.00)	1 (1.00)	0.653 (1.00)	1 (1.00)
OR9G4	5 (2%)	264	0.119 (1.00)	0.56 (1.00)	0.0584 (1.00)	0.695 (1.00)	1 (1.00)	0.653 (1.00)	0.33 (1.00)
TRPV6	7 (3%)	262	0.552 (1.00)	0.215 (1.00)	0.257 (1.00)	0.415 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
ZPBP	5 (2%)	264	0.56 (1.00)	0.496 (1.00)	0.0584 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	0.33 (1.00)
FAM123C	6 (2%)	263	0.463 (1.00)	0.016 (1.00)	0.424 (1.00)	0.0938 (1.00)	1 (1.00)	0.668 (1.00)	1 (1.00)
PCSK4	5 (2%)	264	0.944 (1.00)	0.288 (1.00)	0.0057 (1.00)	0.614 (1.00)	1 (1.00)	0.183 (1.00)	0.653 (1.00)
SLIT3	12 (4%)	257	0.293 (1.00)	0.275 (1.00)	0.126 (1.00)	0.0234 (1.00)	1 (1.00)	0.204 (1.00)	0.527 (1.00)
HOMER1	5 (2%)	264	0.758 (1.00)	0.174 (1.00)	0.355 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
DPP10	7 (3%)	262	0.993 (1.00)	0.262 (1.00)	0.257 (1.00)	0.132 (1.00)	1 (1.00)	1 (1.00)	0.102 (1.00)
KDR	9 (3%)	260	0.376 (1.00)	0.241 (1.00)	0.496 (1.00)	0.465 (1.00)	1 (1.00)	0.724 (1.00)	0.724 (1.00)
OR4C12	4 (1%)	265	0.938 (1.00)	0.345 (1.00)	0.3 (1.00)	0.759 (1.00)	1 (1.00)	0.593 (1.00)	1 (1.00)
DYNC1I1	7 (3%)	262	0.953 (1.00)	0.694 (1.00)	0.0516 (1.00)	0.634 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
KIAA1751	7 (3%)	262	0.0248 (1.00)	0.4 (1.00)	1 (1.00)	0.513 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
OR4P4	4 (1%)	265	0.27 (1.00)	0.932 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
DSG3	8 (3%)	261	0.178 (1.00)	0.863 (1.00)	1 (1.00)	0.757 (1.00)	1 (1.00)	0.442 (1.00)	0.711 (1.00)
TRIM72	4 (1%)	265	0.141 (1.00)	0.863 (1.00)	1 (1.00)	0.971 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
MSL3	5 (2%)	264	0.591 (1.00)	0.0888 (1.00)	1 (1.00)	0.407 (1.00)	1 (1.00)	0.183 (1.00)	1 (1.00)
NEU4	4 (1%)	265	0.166 (1.00)	0.926 (1.00)	0.135 (1.00)	0.614 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
DEFB114	3 (1%)	266	0.621 (1.00)	0.744 (1.00)	0.046 (1.00)		1 (1.00)	1 (1.00)	0.554 (1.00)
PDGFRA	8 (3%)	261	0.565 (1.00)	0.817 (1.00)	0.265 (1.00)	0.838 (1.00)	1 (1.00)	0.711 (1.00)	0.442 (1.00)
CHL1	8 (3%)	261	0.995 (1.00)	0.315 (1.00)	0.715 (1.00)	0.279 (1.00)	1 (1.00)	0.711 (1.00)	1 (1.00)
FRRS1	6 (2%)	263	0.372 (1.00)	0.609 (1.00)	0.424 (1.00)	0.508 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
EEF1A1	5 (2%)	264	0.76 (1.00)	0.532 (1.00)	0.0057 (1.00)	0.903 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
OR2T27	4 (1%)	265	0.735 (1.00)	0.988 (1.00)	0.135 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR7G2	5 (2%)	264	0.000983 (1.00)	0.909 (1.00)	1 (1.00)	0.407 (1.00)	1 (1.00)	0.183 (1.00)	0.653 (1.00)
PIK3CG	10 (4%)	259	0.426 (1.00)	0.733 (1.00)	0.176 (1.00)	0.631 (1.00)	1 (1.00)	0.0773 (1.00)	0.0773 (1.00)
TXNDC3	6 (2%)	263	0.89 (1.00)	0.515 (1.00)	1 (1.00)	0.756 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
SEPT12	5 (2%)	264	0.685 (1.00)	0.224 (1.00)	1 (1.00)		1 (1.00)	0.653 (1.00)	1 (1.00)
MUC4	8 (3%)	261	0.641 (1.00)	0.396 (1.00)	1 (1.00)	0.681 (1.00)	1 (1.00)	0.711 (1.00)	0.267 (1.00)
SCN7A	7 (3%)	262	0.0737 (1.00)	0.659 (1.00)	0.705 (1.00)	0.756 (1.00)	1 (1.00)	0.682 (1.00)	0.438 (1.00)
WNT2	5 (2%)	264	0.773 (1.00)	0.577 (1.00)	0.355 (1.00)	0.407 (1.00)	1 (1.00)	0.183 (1.00)	0.33 (1.00)
AP3S1	3 (1%)	266	0.556 (1.00)	0.778 (1.00)	0.555 (1.00)	0.109 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR5I1	4 (1%)	265	0.82 (1.00)	0.118 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.593 (1.00)
ZNF711	5 (2%)	264	0.88 (1.00)	0.713 (1.00)	0.657 (1.00)	0.929 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
GABRE	6 (2%)	263	0.473 (1.00)	0.834 (1.00)	0.67 (1.00)	0.407 (1.00)	1 (1.00)	0.0815 (1.00)	1 (1.00)
KIF2B	7 (3%)	262	0.289 (1.00)	0.539 (1.00)	0.102 (1.00)	0.739 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
ABCC9	9 (3%)	260	0.742 (1.00)	0.603 (1.00)	0.727 (1.00)	0.555 (1.00)	1 (1.00)	1 (1.00)	0.28 (1.00)
GPC4	5 (2%)	264	0.434 (1.00)	0.182 (1.00)	1 (1.00)	0.885 (1.00)	1 (1.00)	1 (1.00)	0.653 (1.00)
PTPRT	9 (3%)	260	0.582 (1.00)	0.813 (1.00)	0.291 (1.00)	0.59 (1.00)	0.0974 (1.00)	0.28 (1.00)	0.28 (1.00)
GRM3	8 (3%)	261	0.694 (1.00)	0.0435 (1.00)	1 (1.00)	0.692 (1.00)	1 (1.00)	0.0592 (1.00)	0.0592 (1.00)
UGT3A2	6 (2%)	263	0.147 (1.00)	0.945 (1.00)	0.0243 (1.00)	0.929 (1.00)	1 (1.00)	0.384 (1.00)	1 (1.00)
GALK2	5 (2%)	264	0.642 (1.00)	0.431 (1.00)	0.657 (1.00)	0.513 (1.00)	0.0549 (1.00)	1 (1.00)	1 (1.00)
LRP2	20 (7%)	249	0.659 (1.00)	0.405 (1.00)	0.34 (1.00)	0.45 (1.00)	1 (1.00)	0.622 (1.00)	0.622 (1.00)
OR5D18	4 (1%)	265	0.789 (1.00)	0.406 (1.00)	0.621 (1.00)	0.0744 (1.00)	1 (1.00)	0.593 (1.00)	1 (1.00)
PALM2-AKAP2	8 (3%)	261	0.392 (1.00)	0.433 (1.00)	0.265 (1.00)	0.87 (1.00)	1 (1.00)	0.711 (1.00)	1 (1.00)
SIM2	6 (2%)	263	0.148 (1.00)	0.312 (1.00)	0.424 (1.00)	0.681 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
NEFH	6 (2%)	263	0.965 (1.00)	0.93 (1.00)	0.424 (1.00)	0.903 (1.00)	1 (1.00)	0.384 (1.00)	0.384 (1.00)
OR5K4	4 (1%)	265	0.589 (1.00)	0.136 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
TMPRSS6	7 (3%)	262	0.901 (1.00)	0.973 (1.00)	0.257 (1.00)	0.248 (1.00)	1 (1.00)	0.438 (1.00)	1 (1.00)
UBE2NL	3 (1%)	266	0.939 (1.00)	0.0492 (1.00)	0.296 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
NPY5R	4 (1%)	265	0.988 (1.00)	0.604 (1.00)	0.3 (1.00)	0.306 (1.00)	1 (1.00)	1 (1.00)	0.311 (1.00)
TJAP1	5 (2%)	264	0.743 (1.00)	0.921 (1.00)	0.0584 (1.00)	0.311 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
GPR6	5 (2%)	264	0.248 (1.00)	0.622 (1.00)	1 (1.00)	0.695 (1.00)	1 (1.00)	1 (1.00)	0.653 (1.00)
CALR3	5 (2%)	264	0.17 (1.00)	0.0485 (1.00)	0.355 (1.00)	0.31 (1.00)	1 (1.00)	0.33 (1.00)	1 (1.00)
EPHB1	7 (3%)	262	0.779 (1.00)	0.541 (1.00)	0.705 (1.00)	0.198 (1.00)	1 (1.00)	0.438 (1.00)	0.102 (1.00)
FOXR2	4 (1%)	265	0.276 (1.00)	0.39 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
PLXNB3	7 (3%)	262	0.0489 (1.00)	0.51 (1.00)	0.705 (1.00)	0.903 (1.00)	1 (1.00)	0.682 (1.00)	1 (1.00)
OR10A3	4 (1%)	265	0.187 (1.00)	0.181 (1.00)	0.621 (1.00)	0.229 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
PPP1R3A	7 (3%)	262	0.662 (1.00)	0.771 (1.00)	0.257 (1.00)	0.757 (1.00)	1 (1.00)	0.438 (1.00)	1 (1.00)
TGM2	7 (3%)	262	0.445 (1.00)	0.261 (1.00)	0.705 (1.00)	0.541 (1.00)	1 (1.00)	0.212 (1.00)	1 (1.00)
PCDH11Y	5 (2%)	264	0.983 (1.00)	0.763 (1.00)	0.163 (1.00)	0.508 (1.00)	1 (1.00)	0.183 (1.00)	0.183 (1.00)
PIK3C2G	7 (3%)	262	0.126 (1.00)	0.427 (1.00)	0.00978 (1.00)	0.146 (1.00)	1 (1.00)	0.0341 (1.00)	0.682 (1.00)
AMPH	6 (2%)	263	0.542 (1.00)	0.61 (1.00)	0.193 (1.00)	0.903 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
SERPINB4	4 (1%)	265	0.379 (1.00)	0.79 (1.00)	0.621 (1.00)	0.146 (1.00)	1 (1.00)	1 (1.00)	0.311 (1.00)
THSD7B	7 (3%)	262	0.0477 (1.00)	0.0359 (1.00)	0.428 (1.00)	0.508 (1.00)	1 (1.00)	1 (1.00)	0.102 (1.00)
CFHR4	4 (1%)	265	0.203 (1.00)	0.575 (1.00)	0.621 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	0.311 (1.00)
FADS6	4 (1%)	265	0.34 (1.00)	0.0402 (1.00)	0.135 (1.00)	0.776 (1.00)	1 (1.00)	0.593 (1.00)	0.593 (1.00)
RBMS3	5 (2%)	264	0.573 (1.00)	0.389 (1.00)	0.355 (1.00)	0.963 (1.00)	1 (1.00)	0.33 (1.00)	1 (1.00)
NMUR2	5 (2%)	264	0.701 (1.00)	0.483 (1.00)	0.657 (1.00)	0.614 (1.00)	1 (1.00)	0.183 (1.00)	0.653 (1.00)
RARA	5 (2%)	264	0.968 (1.00)	0.508 (1.00)	1 (1.00)	0.195 (1.00)	1 (1.00)	0.0359 (1.00)	0.183 (1.00)
RABGGTA	4 (1%)	265	0.106 (1.00)	0.754 (1.00)	0.621 (1.00)	0.635 (1.00)	1 (1.00)	0.593 (1.00)	1 (1.00)
NLRP5	8 (3%)	261	0.434 (1.00)	0.443 (1.00)	0.715 (1.00)	0.0376 (1.00)	1 (1.00)	0.442 (1.00)	0.442 (1.00)
OR4D5	4 (1%)	265	0.53 (1.00)	0.0949 (1.00)	0.3 (1.00)	0.759 (1.00)	1 (1.00)	0.0947 (1.00)	0.0947 (1.00)
PAN3	6 (2%)	263	0.765 (1.00)	0.314 (1.00)	1 (1.00)	0.616 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
ANKRD52	6 (2%)	263	0.716 (1.00)	0.21 (1.00)	1 (1.00)	0.248 (1.00)	1 (1.00)	0.384 (1.00)	0.0815 (1.00)
MRM1	4 (1%)	265	0.155 (1.00)	0.595 (1.00)	1 (1.00)		1 (1.00)	0.593 (1.00)	0.0947 (1.00)
PRR21	3 (1%)	266	0.471 (1.00)	0.00892 (1.00)	0.555 (1.00)	0.759 (1.00)	1 (1.00)	0.554 (1.00)	1 (1.00)
SIM1	7 (3%)	262	0.529 (1.00)	0.923 (1.00)	0.705 (1.00)	0.279 (1.00)	1 (1.00)	1 (1.00)	0.102 (1.00)
ACVR2A	5 (2%)	264	0.983 (1.00)	0.689 (1.00)	1 (1.00)	0.513 (1.00)	1 (1.00)	0.33 (1.00)	0.33 (1.00)
DUSP22	4 (1%)	265	0.0841 (1.00)	0.324 (1.00)	0.621 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	0.311 (1.00)
DUSP27	8 (3%)	261	0.343 (1.00)	0.918 (1.00)	0.142 (1.00)	0.739 (1.00)	1 (1.00)	0.267 (1.00)	0.267 (1.00)
STEAP1	4 (1%)	265	0.148 (1.00)	0.343 (1.00)	1 (1.00)		1 (1.00)	0.593 (1.00)	1 (1.00)
SVOP	3 (1%)	266	0.327 (1.00)	0.292 (1.00)	0.555 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
HOOK1	6 (2%)	263	0.503 (1.00)	0.0516 (1.00)	1 (1.00)	0.0597 (1.00)	1 (1.00)	0.181 (1.00)	0.181 (1.00)
CRTAC1	6 (2%)	263	0.87 (1.00)	0.44 (1.00)	1 (1.00)	0.73 (1.00)	1 (1.00)	1 (1.00)	0.384 (1.00)
AADACL4	5 (2%)	264	0.524 (1.00)	0.327 (1.00)	0.657 (1.00)	0.146 (1.00)	1 (1.00)	0.33 (1.00)	0.653 (1.00)
KCNU1	6 (2%)	263	0.806 (1.00)	0.978 (1.00)	0.67 (1.00)	0.513 (1.00)	1 (1.00)	0.668 (1.00)	1 (1.00)
MXRA5	12 (4%)	257	0.385 (1.00)	0.227 (1.00)	0.126 (1.00)	0.185 (1.00)	1 (1.00)	0.111 (1.00)	0.111 (1.00)
KLF17	5 (2%)	264	0.208 (1.00)	0.763 (1.00)	1 (1.00)	0.513 (1.00)	1 (1.00)	0.653 (1.00)	0.33 (1.00)
KRT19	5 (2%)	264	0.952 (1.00)	0.935 (1.00)	0.0057 (1.00)	0.776 (1.00)	1 (1.00)	0.33 (1.00)	1 (1.00)
BRAF	5 (2%)	264	0.335 (1.00)	0.487 (1.00)	0.355 (1.00)	0.0938 (1.00)	1 (1.00)	0.33 (1.00)	0.33 (1.00)
KCNN2	4 (1%)	265	0.667 (1.00)	0.59 (1.00)	0.621 (1.00)	0.128 (1.00)	1 (1.00)	0.311 (1.00)	0.593 (1.00)
UGT2A1	5 (2%)	264	0.677 (1.00)	0.272 (1.00)	0.0584 (1.00)	0.576 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
BCAR3	7 (3%)	262	0.0808 (1.00)	0.562 (1.00)	0.257 (1.00)	0.428 (1.00)	1 (1.00)	0.102 (1.00)	1 (1.00)
KRT222	3 (1%)	266	0.82 (1.00)	0.711 (1.00)	0.046 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
LRRIQ1	8 (3%)	261	0.155 (1.00)	0.933 (1.00)	1 (1.00)	0.115 (1.00)	1 (1.00)	0.711 (1.00)	1 (1.00)
MAPK8IP2	3 (1%)	266	0.119 (1.00)	0.202 (1.00)	1 (1.00)		1 (1.00)	0.236 (1.00)	0.236 (1.00)
HNF4A	6 (2%)	263	0.877 (1.00)	0.47 (1.00)	0.193 (1.00)	0.559 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
GON4L	9 (3%)	260	0.667 (1.00)	0.618 (1.00)	1 (1.00)	0.756 (1.00)	1 (1.00)	0.47 (1.00)	0.28 (1.00)
MAGEB6	5 (2%)	264	0.368 (1.00)	0.704 (1.00)	0.355 (1.00)	0.346 (1.00)	1 (1.00)	0.653 (1.00)	1 (1.00)
RFX6	7 (3%)	262	0.751 (1.00)	0.635 (1.00)	0.705 (1.00)	0.631 (1.00)	0.0763 (1.00)	0.682 (1.00)	0.438 (1.00)
SLC17A6	5 (2%)	264	0.465 (1.00)	0.41 (1.00)	0.657 (1.00)	0.929 (1.00)	1 (1.00)	0.183 (1.00)	0.183 (1.00)
PROKR2	5 (2%)	264	0.379 (1.00)	0.0445 (1.00)	1 (1.00)	0.386 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
RAB21	3 (1%)	266	0.00705 (1.00)	0.46 (1.00)	0.555 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
CEP250	10 (4%)	259	0.168 (1.00)	0.287 (1.00)	0.503 (1.00)	0.0193 (1.00)	1 (1.00)	0.178 (1.00)	1 (1.00)
REPIN1	3 (1%)	266	0.177 (1.00)	0.725 (1.00)	0.296 (1.00)		1 (1.00)	0.554 (1.00)	1 (1.00)
SRCRB4D	5 (2%)	264	0.134 (1.00)	0.142 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
CYLC2	4 (1%)	265	0.0213 (1.00)	0.933 (1.00)	1 (1.00)	0.229 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
CCDC60	6 (2%)	263	0.636 (1.00)	0.981 (1.00)	1 (1.00)	0.631 (1.00)	1 (1.00)	0.384 (1.00)	0.384 (1.00)
DMRTB1	4 (1%)	265	0.758 (1.00)	0.39 (1.00)	0.135 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
STARD8	7 (3%)	262	0.402 (1.00)	0.671 (1.00)	0.257 (1.00)	0.383 (1.00)	1 (1.00)	0.682 (1.00)	0.682 (1.00)
KLK15	4 (1%)	265	0.397 (1.00)	0.98 (1.00)	0.135 (1.00)	0.146 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
FANK1	4 (1%)	265	0.682 (1.00)	0.954 (1.00)	0.621 (1.00)	0.776 (1.00)	1 (1.00)	0.0947 (1.00)	0.0947 (1.00)
ENPEP	8 (3%)	261	0.905 (1.00)	0.733 (1.00)	1 (1.00)	0.46 (1.00)	1 (1.00)	0.442 (1.00)	1 (1.00)
OR13C8	4 (1%)	265	0.728 (1.00)	0.403 (1.00)	0.621 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
FPR2	4 (1%)	265	0.951 (1.00)	0.0544 (1.00)	1 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
UBASH3A	7 (3%)	262	0.973 (1.00)	0.356 (1.00)	0.705 (1.00)	0.111 (1.00)	1 (1.00)	0.438 (1.00)	0.438 (1.00)
KCNH5	7 (3%)	262	0.568 (1.00)	0.705 (1.00)	0.705 (1.00)	0.495 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
SPRYD5	3 (1%)	266	0.271 (1.00)	0.207 (1.00)	0.296 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
OR5K3	4 (1%)	265	0.931 (1.00)	0.705 (1.00)	0.135 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
ZSCAN18	4 (1%)	265	0.621 (1.00)	0.771 (1.00)	0.3 (1.00)	0.614 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
NUP210L	9 (3%)	260	0.982 (1.00)	0.24 (1.00)	0.727 (1.00)	0.266 (1.00)	0.0974 (1.00)	0.724 (1.00)	0.724 (1.00)
GJD4	3 (1%)	266	0.14 (1.00)	0.649 (1.00)	1 (1.00)		1 (1.00)	0.236 (1.00)	0.236 (1.00)
ELTD1	5 (2%)	264	0.799 (1.00)	0.349 (1.00)	1 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
KCTD2	3 (1%)	266	0.507 (1.00)	0.365 (1.00)	0.555 (1.00)	0.229 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
CHRM2	4 (1%)	265	0.343 (1.00)	0.345 (1.00)	0.621 (1.00)	0.576 (1.00)	1 (1.00)	0.593 (1.00)	0.311 (1.00)
OR2T6	4 (1%)	265	0.3 (1.00)	0.905 (1.00)	0.135 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
OR5A1	4 (1%)	265	0.786 (1.00)	0.668 (1.00)	0.135 (1.00)	0.614 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
OR4K13	4 (1%)	265	0.272 (1.00)	0.459 (1.00)	0.621 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
CCDC120	4 (1%)	265	0.935 (1.00)	0.483 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
GAP43	3 (1%)	266	0.742 (1.00)	0.156 (1.00)	0.555 (1.00)	0.109 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
GRHL3	6 (2%)	263	0.797 (1.00)	0.634 (1.00)	0.0243 (1.00)	0.776 (1.00)	1 (1.00)	0.384 (1.00)	1 (1.00)
KLHL13	5 (2%)	264	0.449 (1.00)	0.116 (1.00)	0.657 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.183 (1.00)
LGALS9B	3 (1%)	266	0.475 (1.00)	0.493 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
SSPO	10 (4%)	259	0.394 (1.00)	0.232 (1.00)	0.751 (1.00)	0.757 (1.00)	1 (1.00)	0.73 (1.00)	0.73 (1.00)
OR51T1	4 (1%)	265	0.509 (1.00)	0.844 (1.00)	0.3 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
CDC42EP1	3 (1%)	266	0.0716 (1.00)	0.125 (1.00)	0.555 (1.00)	0.515 (1.00)	1 (1.00)	0.554 (1.00)	1 (1.00)
FKBP6	4 (1%)	265	0.441 (1.00)	0.701 (1.00)	0.621 (1.00)		1 (1.00)	0.593 (1.00)	0.0947 (1.00)
XK	4 (1%)	265	0.396 (1.00)	0.64 (1.00)	0.135 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
TNFSF11	4 (1%)	265	0.685 (1.00)	0.182 (1.00)	0.621 (1.00)	0.73 (1.00)	1 (1.00)	0.593 (1.00)	0.593 (1.00)
GPR135	3 (1%)	266	0.865 (1.00)	0.806 (1.00)	1 (1.00)	0.515 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
GRIN2A	10 (4%)	259	0.406 (1.00)	0.652 (1.00)	0.338 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
NCCRP1	3 (1%)	266	0.407 (1.00)	0.219 (1.00)	0.555 (1.00)	0.776 (1.00)	1 (1.00)	0.236 (1.00)	1 (1.00)
OR4C16	4 (1%)	265	0.379 (1.00)	0.373 (1.00)	0.135 (1.00)	0.776 (1.00)	0.0441 (1.00)	0.593 (1.00)	0.593 (1.00)
OR4N4	4 (1%)	265	0.0381 (1.00)	0.572 (1.00)	1 (1.00)	0.0806 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
TEKT4	4 (1%)	265	0.088 (1.00)	0.00575 (1.00)	1 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
FLT3	6 (2%)	263	0.494 (1.00)	0.904 (1.00)	0.0243 (1.00)	0.513 (1.00)	1 (1.00)	1 (1.00)	0.181 (1.00)
CKMT1A	3 (1%)	266	0.437 (1.00)	0.0472 (1.00)	0.555 (1.00)	0.84 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
DCHS1	9 (3%)	260	0.251 (1.00)	0.427 (1.00)	0.727 (1.00)	0.317 (1.00)	1 (1.00)	0.28 (1.00)	1 (1.00)
UBE2M	3 (1%)	266	0.27 (1.00)	0.915 (1.00)	0.555 (1.00)	0.229 (1.00)	1 (1.00)	0.236 (1.00)	1 (1.00)
NOX3	5 (2%)	264	0.832 (1.00)	0.851 (1.00)	0.657 (1.00)	0.73 (1.00)	1 (1.00)	0.33 (1.00)	0.33 (1.00)
COL1A2	9 (3%)	260	0.5 (1.00)	0.635 (1.00)	0.291 (1.00)	0.84 (1.00)	1 (1.00)	0.147 (1.00)	0.47 (1.00)
OR51G1	3 (1%)	266	0.411 (1.00)	0.655 (1.00)	0.046 (1.00)		1 (1.00)	0.554 (1.00)	1 (1.00)
OR5D16	3 (1%)	266	0.0438 (1.00)	0.146 (1.00)	1 (1.00)	0.904 (1.00)	1 (1.00)	1 (1.00)	0.236 (1.00)
AFM	5 (2%)	264	0.926 (1.00)	0.447 (1.00)	1 (1.00)	0.929 (1.00)	1 (1.00)	0.33 (1.00)	1 (1.00)
DPT	3 (1%)	266	0.441 (1.00)	0.871 (1.00)	1 (1.00)	0.73 (1.00)	1 (1.00)	0.236 (1.00)	0.554 (1.00)
FCER1A	3 (1%)	266	0.469 (1.00)	0.202 (1.00)	1 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
GFRAL	4 (1%)	265	0.745 (1.00)	0.0347 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	0.311 (1.00)
PRKG2	5 (2%)	264	0.0146 (1.00)	0.576 (1.00)	0.355 (1.00)	0.776 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
UFSP1	3 (1%)	266	0.702 (1.00)	0.563 (1.00)	1 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
DUS4L	4 (1%)	265	0.601 (1.00)	0.775 (1.00)	0.621 (1.00)	0.148 (1.00)	1 (1.00)	0.0947 (1.00)	0.593 (1.00)
GABRG2	5 (2%)	264	0.688 (1.00)	0.531 (1.00)	1 (1.00)	0.515 (1.00)	1 (1.00)	0.653 (1.00)	0.653 (1.00)
ART1	4 (1%)	265	0.529 (1.00)	0.536 (1.00)	1 (1.00)	0.146 (1.00)	1 (1.00)	1 (1.00)	0.593 (1.00)
CDKN2A	3 (1%)	266	0.0157 (1.00)	0.0937 (1.00)	1 (1.00)	0.306 (1.00)	1 (1.00)	0.236 (1.00)	1 (1.00)
EPHA1	6 (2%)	263	0.601 (1.00)	0.841 (1.00)	1 (1.00)	0.229 (1.00)	0.0657 (1.00)	0.668 (1.00)	1 (1.00)
KCNV1	5 (2%)	264	0.548 (1.00)	0.269 (1.00)	0.355 (1.00)	0.616 (1.00)	1 (1.00)	0.183 (1.00)	0.0359 (1.00)
OR2H1	4 (1%)	265	0.698 (1.00)	0.433 (1.00)	1 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
PROL1	3 (1%)	266	0.917 (1.00)	0.124 (1.00)	1 (1.00)		1 (1.00)	0.554 (1.00)	1 (1.00)
TMTC1	6 (2%)	263	0.641 (1.00)	0.0482 (1.00)	0.67 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
GNAT3	3 (1%)	266	0.389 (1.00)	0.272 (1.00)	0.555 (1.00)	0.229 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
ELFN2	5 (2%)	264	0.904 (1.00)	0.237 (1.00)	0.163 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	0.653 (1.00)
ELMO1	7 (3%)	262	0.536 (1.00)	0.631 (1.00)	0.705 (1.00)	0.0597 (1.00)	0.0763 (1.00)	0.438 (1.00)	1 (1.00)
OR6C75	3 (1%)	266	0.244 (1.00)	0.524 (1.00)	0.555 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
NLRP12	8 (3%)	261	0.385 (1.00)	0.275 (1.00)	0.465 (1.00)	0.279 (1.00)	1 (1.00)	0.267 (1.00)	0.267 (1.00)
TMEM151A	3 (1%)	266	0.121 (1.00)	0.903 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
COL5A3	9 (3%)	260	0.424 (1.00)	0.394 (1.00)	0.727 (1.00)	0.334 (1.00)	1 (1.00)	0.28 (1.00)	0.724 (1.00)
H1FX	3 (1%)	266	0.815 (1.00)	0.641 (1.00)	1 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
HRH2	5 (2%)	264	0.982 (1.00)	0.127 (1.00)	0.657 (1.00)	0.0806 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
ITGAM	7 (3%)	262	0.037 (1.00)	0.781 (1.00)	0.257 (1.00)	0.851 (1.00)	1 (1.00)	0.438 (1.00)	1 (1.00)
TCN1	4 (1%)	265	0.763 (1.00)	0.284 (1.00)	0.621 (1.00)		1 (1.00)	0.0947 (1.00)	0.0947 (1.00)
NACA	7 (3%)	262	0.396 (1.00)	0.206 (1.00)	0.705 (1.00)	0.415 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR2T12	4 (1%)	265	0.357 (1.00)	0.956 (1.00)	0.621 (1.00)	0.311 (1.00)	1 (1.00)	0.593 (1.00)	1 (1.00)
PTPN11	6 (2%)	263	0.594 (1.00)	0.69 (1.00)	1 (1.00)	0.805 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
ZDBF2	7 (3%)	262	0.763 (1.00)	0.448 (1.00)	0.257 (1.00)	0.757 (1.00)	1 (1.00)	1 (1.00)	0.438 (1.00)
PDYN	4 (1%)	265	0.471 (1.00)	0.873 (1.00)	1 (1.00)	0.614 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
CACNA1S	11 (4%)	258	0.431 (1.00)	0.0825 (1.00)	0.0613 (1.00)	0.664 (1.00)	1 (1.00)	0.746 (1.00)	0.332 (1.00)
TSGA13	4 (1%)	265	0.888 (1.00)	0.729 (1.00)	0.621 (1.00)	0.229 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
KIF21B	9 (3%)	260	0.111 (1.00)	0.511 (1.00)	0.496 (1.00)	0.0597 (1.00)	1 (1.00)	1 (1.00)	0.47 (1.00)
CCDC45	5 (2%)	264	0.2 (1.00)	0.356 (1.00)	0.355 (1.00)	0.714 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
CYP4F2	5 (2%)	264	0.59 (1.00)	0.447 (1.00)	1 (1.00)		1 (1.00)	0.183 (1.00)	0.183 (1.00)
FCRL2	5 (2%)	264	0.514 (1.00)	0.442 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.183 (1.00)	0.183 (1.00)
OR2F2	3 (1%)	266	0.0774 (1.00)	0.409 (1.00)	0.296 (1.00)		1 (1.00)	0.0308 (1.00)	0.0308 (1.00)
OR2L8	3 (1%)	266	0.000669 (1.00)	0.378 (1.00)	0.296 (1.00)		1 (1.00)	1 (1.00)	0.0308 (1.00)
SCAF1	6 (2%)	263	0.918 (1.00)	0.411 (1.00)	1 (1.00)	0.195 (1.00)	1 (1.00)	0.384 (1.00)	1 (1.00)
FAM102A	3 (1%)	266	0.663 (1.00)	0.267 (1.00)	0.296 (1.00)	0.306 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
SIGLEC8	5 (2%)	264	0.738 (1.00)	0.954 (1.00)	1 (1.00)	0.283 (1.00)	1 (1.00)	0.183 (1.00)	1 (1.00)
TRPA1	7 (3%)	262	0.0174 (1.00)	0.683 (1.00)	1 (1.00)	0.146 (1.00)	1 (1.00)	0.682 (1.00)	1 (1.00)
RELN	14 (5%)	255	0.339 (1.00)	0.581 (1.00)	0.776 (1.00)	0.644 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
DKC1	5 (2%)	264	0.61 (1.00)	0.822 (1.00)	0.355 (1.00)	0.776 (1.00)	1 (1.00)	0.653 (1.00)	0.183 (1.00)
DSG4	7 (3%)	262	0.125 (1.00)	0.829 (1.00)	0.257 (1.00)	0.513 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
OR51F1	3 (1%)	266	0.497 (1.00)	0.244 (1.00)	0.046 (1.00)		1 (1.00)	0.0308 (1.00)	1 (1.00)
ADRA2C	4 (1%)	265	0.0847 (1.00)	0.683 (1.00)	0.621 (1.00)	0.929 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
MFAP4	3 (1%)	266	0.979 (1.00)	0.553 (1.00)	0.296 (1.00)		1 (1.00)	0.554 (1.00)	0.554 (1.00)
F5	9 (3%)	260	0.889 (1.00)	0.312 (1.00)	0.291 (1.00)	0.948 (1.00)	1 (1.00)	0.724 (1.00)	1 (1.00)
WSCD2	5 (2%)	264	0.0782 (1.00)	0.824 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
ABP1	7 (3%)	262	0.392 (1.00)	0.118 (1.00)	0.102 (1.00)	0.852 (1.00)	1 (1.00)	0.438 (1.00)	0.438 (1.00)
C15ORF2	7 (3%)	262	0.264 (1.00)	0.997 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.212 (1.00)
CTSG	4 (1%)	265	0.636 (1.00)	0.479 (1.00)	0.621 (1.00)		1 (1.00)	0.593 (1.00)	0.593 (1.00)
IQSEC3	6 (2%)	263	0.203 (1.00)	0.587 (1.00)	1 (1.00)	0.0574 (1.00)	1 (1.00)	1 (1.00)	0.668 (1.00)
PEX14	4 (1%)	265	0.145 (1.00)	0.734 (1.00)	0.135 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
WDR92	4 (1%)	265	0.694 (1.00)	0.952 (1.00)	0.621 (1.00)	0.229 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
COL8A2	3 (1%)	266	0.503 (1.00)	0.306 (1.00)	0.296 (1.00)		0.0332 (1.00)	1 (1.00)	1 (1.00)
KIAA1598	4 (1%)	265	0.807 (1.00)	0.0965 (1.00)	0.621 (1.00)	0.346 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
OR4Q3	3 (1%)	266	0.00737 (1.00)	0.0618 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.0308 (1.00)	0.236 (1.00)
SMARCA1	7 (3%)	262	0.349 (1.00)	0.0898 (1.00)	0.705 (1.00)	0.895 (1.00)	1 (1.00)	0.438 (1.00)	0.438 (1.00)
GZMB	3 (1%)	266	0.64 (1.00)	0.606 (1.00)	0.296 (1.00)		1 (1.00)	0.554 (1.00)	1 (1.00)
POU4F2	4 (1%)	265	0.848 (1.00)	0.93 (1.00)	0.621 (1.00)	0.616 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
ST6GAL2	4 (1%)	265	0.987 (1.00)	0.299 (1.00)	0.0162 (1.00)	0.0552 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
GALK1	3 (1%)	266	0.0343 (1.00)	0.947 (1.00)	1 (1.00)		1 (1.00)	0.236 (1.00)	0.236 (1.00)
MMP13	4 (1%)	265	0.634 (1.00)	0.069 (1.00)	0.3 (1.00)	0.0806 (1.00)	1 (1.00)	0.311 (1.00)	0.311 (1.00)
IL22	3 (1%)	266	0.546 (1.00)	0.239 (1.00)	1 (1.00)	0.229 (1.00)	1 (1.00)	0.554 (1.00)	1 (1.00)
TNFSF9	3 (1%)	266	0.102 (1.00)	0.4 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
ABCB4	8 (3%)	261	0.0277 (1.00)	0.314 (1.00)	0.142 (1.00)	0.947 (1.00)	1 (1.00)	0.442 (1.00)	0.0592 (1.00)
ACRC	6 (2%)	263	0.668 (1.00)	0.505 (1.00)	0.67 (1.00)	0.559 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
CABIN1	10 (4%)	259	0.0729 (1.00)	0.394 (1.00)	0.176 (1.00)	0.763 (1.00)	1 (1.00)	0.73 (1.00)	0.73 (1.00)
CALCA	3 (1%)	266	0.202 (1.00)	0.419 (1.00)	0.555 (1.00)	0.229 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
FXR2	4 (1%)	265	0.592 (1.00)	0.000399 (1.00)	0.621 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
GRM6	6 (2%)	263	0.533 (1.00)	0.241 (1.00)	1 (1.00)	0.109 (1.00)	1 (1.00)	0.384 (1.00)	0.181 (1.00)
KIF4B	7 (3%)	262	0.769 (1.00)	0.721 (1.00)	0.257 (1.00)	0.739 (1.00)	1 (1.00)	0.682 (1.00)	0.212 (1.00)
PODNL1	3 (1%)	266	0.0673 (1.00)	0.0372 (1.00)	1 (1.00)		1 (1.00)	0.236 (1.00)	1 (1.00)
DBH	6 (2%)	263	0.0996 (1.00)	0.187 (1.00)	0.193 (1.00)	0.415 (1.00)	1 (1.00)	0.181 (1.00)	0.181 (1.00)
LILRB1	5 (2%)	264	0.0841 (1.00)	0.44 (1.00)	0.657 (1.00)		1 (1.00)	0.653 (1.00)	0.183 (1.00)
TMEM146	6 (2%)	263	0.45 (1.00)	0.775 (1.00)	1 (1.00)	0.631 (1.00)	0.00124 (1.00)	0.181 (1.00)	0.181 (1.00)
MAGEB3	4 (1%)	265	0.676 (1.00)	0.0645 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
PLCXD3	4 (1%)	265	0.0331 (1.00)	0.309 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
CCDC158	6 (2%)	263	0.816 (1.00)	0.367 (1.00)	0.424 (1.00)	0.151 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
GUCA1C	3 (1%)	266	0.567 (1.00)	0.588 (1.00)	0.046 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
PAX1	4 (1%)	265	0.413 (1.00)	0.363 (1.00)	1 (1.00)	0.229 (1.00)	1 (1.00)	0.311 (1.00)	1 (1.00)
EPPK1	8 (3%)	261	0.113 (1.00)	0.353 (1.00)	0.465 (1.00)	0.184 (1.00)	1 (1.00)	0.442 (1.00)	0.442 (1.00)
NOBOX	3 (1%)	266	0.216 (1.00)	0.878 (1.00)	1 (1.00)		1 (1.00)	1 (1.00)	1 (1.00)
PKD1L2	10 (4%)	259	0.952 (1.00)	0.311 (1.00)	0.176 (1.00)	0.852 (1.00)	1 (1.00)	1 (1.00)	0.512 (1.00)
FAM190A	4 (1%)	265	0.849 (1.00)	0.791 (1.00)	1 (1.00)	0.146 (1.00)	1 (1.00)	0.593 (1.00)	0.311 (1.00)
UGT2B4	4 (1%)	265	0.688 (1.00)	0.901 (1.00)	0.621 (1.00)		1 (1.00)	1 (1.00)	0.593 (1.00)
NFIB	3 (1%)	266	0.0776 (1.00)	0.909 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.554 (1.00)
ATP13A2	7 (3%)	262	0.0116 (1.00)	0.765 (1.00)	0.705 (1.00)	0.158 (1.00)	1 (1.00)	0.682 (1.00)	0.438 (1.00)
EPHA10	6 (2%)	263	0.86 (1.00)	0.931 (1.00)	0.193 (1.00)	0.614 (1.00)	1 (1.00)	0.384 (1.00)	0.384 (1.00)
ZNF492	3 (1%)	266	0.0754 (1.00)	0.267 (1.00)	0.555 (1.00)	0.73 (1.00)	1 (1.00)	0.554 (1.00)	0.554 (1.00)
OR51B6	3 (1%)	266	0.908 (1.00)	0.712 (1.00)	1 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	1 (1.00)
WWC3	7 (3%)	262	0.746 (1.00)	0.417 (1.00)	0.257 (1.00)	0.346 (1.00)	1 (1.00)	0.438 (1.00)	0.682 (1.00)
NPR1	6 (2%)	263	0.405 (1.00)	0.113 (1.00)	0.67 (1.00)	0.0938 (1.00)	1 (1.00)	0.668 (1.00)	0.668 (1.00)
FAM47A	7 (3%)	262	0.231 (1.00)	0.514 (1.00)	0.257 (1.00)	0.0848 (1.00)	1 (1.00)	1 (1.00)	0.102 (1.00)
RBMXL2	3 (1%)	266	0.0511 (1.00)	0.0747 (1.00)	1 (1.00)		1 (1.00)	0.236 (1.00)	0.236 (1.00)
HSPA6	5 (2%)	264	0.86 (1.00)	0.577 (1.00)	1 (1.00)	0.0938 (1.00)	1 (1.00)	1 (1.00)	0.33 (1.00)
EMILIN1	4 (1%)	265	0.0313 (1.00)	0.872 (1.00)	0.621 (1.00)	0.776 (1.00)	1 (1.00)	1 (1.00)	0.311 (1.00)

'IDH1 MUTATION STATUS' versus 'AGE'

P value = 2.36e-05 (t-test), Q value = 0.068

Table S1. Gene #3: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	269	60.6 (13.2)
IDH1 MUTATED	15	41.1 (13.1)
IDH1 WILD-TYPE	254	61.8 (12.3)

Figure S1. Get High-res Image Gene #3: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'OR5W2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S2. Gene #46: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
OR5W2 MUTATED	5	80.0 (0.0)
OR5W2 WILD-TYPE	203	75.4 (15.5)

Figure S2. Get High-res Image Gene #46: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C21ORF58 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S3. Gene #48: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
C21ORF58 MUTATED	3	80.0 (0.0)
C21ORF58 WILD-TYPE	205	75.4 (15.4)

Figure S3. Get High-res Image Gene #48: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF704 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S4. Gene #93: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ZNF704 MUTATED	3	80.0 (0.0)
ZNF704 WILD-TYPE	205	75.4 (15.4)

Figure S4. Get High-res Image Gene #93: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CDKN2C MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S5. Gene #99: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CDKN2C MUTATED	3	80.0 (0.0)
CDKN2C WILD-TYPE	205	75.4 (15.4)

Figure S5. Get High-res Image Gene #99: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SPAM1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.01e-05 (t-test), Q value = 0.087

Table S6. Gene #114: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
SPAM1 MUTATED	6	80.0 (0.0)
SPAM1 WILD-TYPE	202	75.3 (15.5)

Figure S6. Get High-res Image Gene #114: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF784 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S7. Gene #117: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ZNF784 MUTATED	3	80.0 (0.0)
ZNF784 WILD-TYPE	205	75.4 (15.4)

Figure S7. Get High-res Image Gene #117: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MSLNL MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S8. Gene #134: 'MSLNL MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
MSLNL MUTATED	4	80.0 (0.0)
MSLNL WILD-TYPE	204	75.4 (15.4)

Figure S8. Get High-res Image Gene #134: 'MSLNL MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'NFKBIL2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S9. Gene #149: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
NFKBIL2 MUTATED	4	80.0 (0.0)
NFKBIL2 WILD-TYPE	204	75.4 (15.4)

Figure S9. Get High-res Image Gene #149: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'RBM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S10. Gene #153: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
RBM3 MUTATED	3	80.0 (0.0)
RBM3 WILD-TYPE	205	75.4 (15.4)

Figure S10. Get High-res Image Gene #153: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MAGEC2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S11. Gene #156: 'MAGEC2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
MAGEC2 MUTATED	5	80.0 (0.0)
MAGEC2 WILD-TYPE	203	75.4 (15.5)

Figure S11. Get High-res Image Gene #156: 'MAGEC2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CCDC114 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S12. Gene #166: 'CCDC114 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CCDC114 MUTATED	5	80.0 (0.0)
CCDC114 WILD-TYPE	203	75.4 (15.5)

Figure S12. Get High-res Image Gene #166: 'CCDC114 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHEK1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S13. Gene #182: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CHEK1 MUTATED	3	80.0 (0.0)
CHEK1 WILD-TYPE	205	75.4 (15.4)

Figure S13. Get High-res Image Gene #182: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ARID3B MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S14. Gene #184: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ARID3B MUTATED	3	80.0 (0.0)
ARID3B WILD-TYPE	205	75.4 (15.4)

Figure S14. Get High-res Image Gene #184: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PUF60 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S15. Gene #189: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
PUF60 MUTATED	4	80.0 (0.0)
PUF60 WILD-TYPE	204	75.4 (15.4)

Figure S15. Get High-res Image Gene #189: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'DPEP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S16. Gene #195: 'DPEP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
DPEP1 MUTATED	3	80.0 (0.0)
DPEP1 WILD-TYPE	205	75.4 (15.4)

Figure S16. Get High-res Image Gene #195: 'DPEP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SPIRE2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S17. Gene #219: 'SPIRE2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
SPIRE2 MUTATED	3	80.0 (0.0)
SPIRE2 WILD-TYPE	205	75.4 (15.4)

Figure S17. Get High-res Image Gene #219: 'SPIRE2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CTDSP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S18. Gene #226: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CTDSP1 MUTATED	3	80.0 (0.0)
CTDSP1 WILD-TYPE	205	75.4 (15.4)

Figure S18. Get High-res Image Gene #226: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TLR6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S19. Gene #228: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
TLR6 MUTATED	3	80.0 (0.0)
TLR6 WILD-TYPE	205	75.4 (15.4)

Figure S19. Get High-res Image Gene #228: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'N4BP3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S20. Gene #235: 'N4BP3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
N4BP3 MUTATED	3	80.0 (0.0)
N4BP3 WILD-TYPE	205	75.4 (15.4)

Figure S20. Get High-res Image Gene #235: 'N4BP3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GJB1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S21. Gene #243: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
GJB1 MUTATED	3	80.0 (0.0)
GJB1 WILD-TYPE	205	75.4 (15.4)

Figure S21. Get High-res Image Gene #243: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LEFTY1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S22. Gene #250: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
LEFTY1 MUTATED	3	80.0 (0.0)
LEFTY1 WILD-TYPE	205	75.4 (15.4)

Figure S22. Get High-res Image Gene #250: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ANGPT4 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S23. Gene #252: 'ANGPT4 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ANGPT4 MUTATED	4	80.0 (0.0)
ANGPT4 WILD-TYPE	204	75.4 (15.4)

Figure S23. Get High-res Image Gene #252: 'ANGPT4 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FBXO31 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S24. Gene #253: 'FBXO31 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
FBXO31 MUTATED	4	80.0 (0.0)
FBXO31 WILD-TYPE	204	75.4 (15.4)

Figure S24. Get High-res Image Gene #253: 'FBXO31 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OTUD6A MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S25. Gene #255: 'OTUD6A MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
OTUD6A MUTATED	4	80.0 (0.0)
OTUD6A WILD-TYPE	204	75.4 (15.4)

Figure S25. Get High-res Image Gene #255: 'OTUD6A MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MC3R MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S26. Gene #257: 'MC3R MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
MC3R MUTATED	3	80.0 (0.0)
MC3R WILD-TYPE	205	75.4 (15.4)

Figure S26. Get High-res Image Gene #257: 'MC3R MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C9ORF86 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S27. Gene #260: 'C9ORF86 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
C9ORF86 MUTATED	4	80.0 (0.0)
C9ORF86 WILD-TYPE	204	75.4 (15.4)

Figure S27. Get High-res Image Gene #260: 'C9ORF86 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'HOXD13 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S28. Gene #269: 'HOXD13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
HOXD13 MUTATED	4	80.0 (0.0)
HOXD13 WILD-TYPE	204	75.4 (15.4)

Figure S28. Get High-res Image Gene #269: 'HOXD13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TGM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S29. Gene #286: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
TGM3 MUTATED	5	80.0 (0.0)
TGM3 WILD-TYPE	203	75.4 (15.5)

Figure S29. Get High-res Image Gene #286: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JAG2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S30. Gene #287: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
JAG2 MUTATED	3	80.0 (0.0)
JAG2 WILD-TYPE	205	75.4 (15.4)

Figure S30. Get High-res Image Gene #287: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHP2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S31. Gene #288: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CHP2 MUTATED	3	80.0 (0.0)
CHP2 WILD-TYPE	205	75.4 (15.4)

Figure S31. Get High-res Image Gene #288: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'HNRNPCL1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S32. Gene #292: 'HNRNPCL1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
HNRNPCL1 MUTATED	4	80.0 (0.0)
HNRNPCL1 WILD-TYPE	204	75.4 (15.4)

Figure S32. Get High-res Image Gene #292: 'HNRNPCL1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FOXF1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S33. Gene #297: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
FOXF1 MUTATED	3	80.0 (0.0)
FOXF1 WILD-TYPE	205	75.4 (15.4)

Figure S33. Get High-res Image Gene #297: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JHDM1D MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S34. Gene #298: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
JHDM1D MUTATED	3	80.0 (0.0)
JHDM1D WILD-TYPE	205	75.4 (15.4)

Figure S34. Get High-res Image Gene #298: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LMO1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S35. Gene #310: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
LMO1 MUTATED	3	80.0 (0.0)
LMO1 WILD-TYPE	205	75.4 (15.4)

Figure S35. Get High-res Image Gene #310: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PRKRIP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S36. Gene #312: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
PRKRIP1 MUTATED	3	80.0 (0.0)
PRKRIP1 WILD-TYPE	205	75.4 (15.4)

Figure S36. Get High-res Image Gene #312: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SLC39A4 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S37. Gene #320: 'SLC39A4 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
SLC39A4 MUTATED	3	80.0 (0.0)
SLC39A4 WILD-TYPE	205	75.4 (15.4)

Figure S37. Get High-res Image Gene #320: 'SLC39A4 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF599 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S38. Gene #339: 'ZNF599 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ZNF599 MUTATED	3	80.0 (0.0)
ZNF599 WILD-TYPE	205	75.4 (15.4)

Figure S38. Get High-res Image Gene #339: 'ZNF599 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TNFSF10 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S39. Gene #340: 'TNFSF10 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
TNFSF10 MUTATED	3	80.0 (0.0)
TNFSF10 WILD-TYPE	205	75.4 (15.4)

Figure S39. Get High-res Image Gene #340: 'TNFSF10 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CXCL6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S40. Gene #345: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
CXCL6 MUTATED	3	80.0 (0.0)
CXCL6 WILD-TYPE	205	75.4 (15.4)

Figure S40. Get High-res Image Gene #345: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PSG7 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S41. Gene #353: 'PSG7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
PSG7 MUTATED	3	80.0 (0.0)
PSG7 WILD-TYPE	205	75.4 (15.4)

Figure S41. Get High-res Image Gene #353: 'PSG7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SLITRK6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 6.76e-34 (t-test), Q value = 1.9e-30

Table S42. Gene #370: 'SLITRK6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
SLITRK6 MUTATED	3	60.0 (0.0)
SLITRK6 WILD-TYPE	205	75.7 (15.3)

Figure S42. Get High-res Image Gene #370: 'SLITRK6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MPP7 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S43. Gene #378: 'MPP7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
MPP7 MUTATED	3	80.0 (0.0)
MPP7 WILD-TYPE	205	75.4 (15.4)

Figure S43. Get High-res Image Gene #378: 'MPP7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GUCY1A3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S44. Gene #381: 'GUCY1A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
GUCY1A3 MUTATED	4	80.0 (0.0)
GUCY1A3 WILD-TYPE	204	75.4 (15.4)

Figure S44. Get High-res Image Gene #381: 'GUCY1A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ANO5 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.087

Table S45. Gene #397: 'ANO5 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
ANO5 MUTATED	5	80.0 (0.0)
ANO5 WILD-TYPE	203	75.4 (15.5)

Figure S45. Get High-res Image Gene #397: 'ANO5 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C12ORF50 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S46. Gene #408: 'C12ORF50 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
C12ORF50 MUTATED	3	80.0 (0.0)
C12ORF50 WILD-TYPE	205	75.4 (15.4)

Figure S46. Get High-res Image Gene #408: 'C12ORF50 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FGG MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S47. Gene #410: 'FGG MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
FGG MUTATED	3	80.0 (0.0)
FGG WILD-TYPE	205	75.4 (15.4)

Figure S47. Get High-res Image Gene #410: 'FGG MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SH3GLB2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.087

Table S48. Gene #411: 'SH3GLB2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

	nPatients	Mean (Std.Dev)
ALL	208	75.5 (15.3)
SH3GLB2 MUTATED	3	80.0 (0.0)
SH3GLB2 WILD-TYPE	205	75.4 (15.4)

Figure S48. Get High-res Image Gene #411: 'SH3GLB2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

Methods & Data

Input

Mutation data file = GBM.mutsig.cluster.txt
Clinical data file = GBM.clin.merged.picked.txt
Number of patients = 269
Number of significantly mutated genes = 419
Number of selected clinical features = 7
Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. Location of data archives could not be determined.

References

[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)

[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)

[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)