Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	29.0	2222.0	76.0	-0.296	0.036	1000.0	-1000.0	-0.024	-1000.0
TCGA08_retinoblastoma	26.0	213.0	8.0	-0.074	0.085	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by the Hedgehog family	23.0	1206.0	52.0	-0.253	0.053	1000.0	-1000.0	-0.024	-1000.0
IL23-mediated signaling events	22.0	1358.0	60.0	-0.503	0.036	1000.0	-1000.0	-0.058	-1000.0
IL4-mediated signaling events	21.0	1917.0	91.0	-0.559	0.509	1000.0	-1000.0	-0.084	-1000.0
Osteopontin-mediated events	19.0	724.0	38.0	-0.202	0.037	1000.0	-1000.0	-0.038	-1000.0
Signaling mediated by p38-alpha and p38-beta	19.0	871.0	44.0	-0.164	0.036	1000.0	-1000.0	-0.031	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1316.0	68.0	-0.39	0.184	1000.0	-1000.0	-0.049	-1000.0
Glucocorticoid receptor regulatory network	18.0	2155.0	114.0	-0.455	0.279	1000.0	-1000.0	-0.054	-1000.0
Wnt signaling	18.0	129.0	7.0	-0.126	0.03	1000.0	-1000.0	-0.011	-1000.0
Noncanonical Wnt signaling pathway	17.0	467.0	26.0	-0.126	0.037	1000.0	-1000.0	-0.035	-1000.0
Fc-epsilon receptor I signaling in mast cells	17.0	1723.0	97.0	-0.11	0.047	1000.0	-1000.0	-0.049	-1000.0
Endothelins	17.0	1719.0	96.0	-0.236	0.037	1000.0	-1000.0	-0.034	-1000.0
Syndecan-1-mediated signaling events	16.0	544.0	34.0	-0.129	0.04	1000.0	-1000.0	-0.031	-1000.0
FOXM1 transcription factor network	16.0	828.0	51.0	-0.246	0.048	1000.0	-1000.0	-0.073	-1000.0
Thromboxane A2 receptor signaling	15.0	1635.0	105.0	-0.162	0.055	1000.0	-1000.0	-0.034	-1000.0
Ephrin B reverse signaling	15.0	725.0	48.0	-0.098	0.046	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	14.0	1191.0	85.0	-0.107	0.077	1000.0	-1000.0	-0.059	-1000.0
BCR signaling pathway	14.0	1482.0	99.0	-0.201	0.054	1000.0	-1000.0	-0.053	-1000.0
IL12-mediated signaling events	13.0	1131.0	87.0	-0.211	0.038	1000.0	-1000.0	-0.04	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1230.0	93.0	-0.102	0.051	1000.0	-1000.0	-0.041	-1000.0
EGFR-dependent Endothelin signaling events	13.0	280.0	21.0	-0.076	0.051	1000.0	-1000.0	-0.026	-1000.0
IGF1 pathway	13.0	774.0	57.0	-0.065	0.066	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1084.0	78.0	-0.171	0.072	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	12.0	794.0	63.0	-0.088	0.057	1000.0	-1000.0	-0.039	-1000.0
TCGA08_p53	12.0	90.0	7.0	-0.039	0.037	1000.0	-1000.0	-0.006	-1000.0
Calcium signaling in the CD4+ TCR pathway	12.0	398.0	31.0	-0.2	0.041	1000.0	-1000.0	-0.047	-1000.0
LPA receptor mediated events	12.0	1237.0	102.0	-0.198	0.037	1000.0	-1000.0	-0.065	-1000.0
Glypican 1 network	11.0	557.0	48.0	-0.043	0.036	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	11.0	688.0	62.0	-0.151	0.075	1000.0	-1000.0	-0.037	-1000.0
BMP receptor signaling	10.0	870.0	81.0	-0.151	0.059	1000.0	-1000.0	-0.035	-1000.0
IFN-gamma pathway	10.0	728.0	68.0	-0.102	0.05	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	10.0	382.0	36.0	-0.197	0.036	1000.0	-1000.0	-0.043	-1000.0
IL27-mediated signaling events	10.0	557.0	51.0	-0.183	0.12	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	10.0	727.0	67.0	-0.073	0.039	1000.0	-1000.0	-0.029	-1000.0
Syndecan-2-mediated signaling events	9.0	655.0	69.0	-0.12	0.039	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	9.0	748.0	82.0	-0.107	0.041	1000.0	-1000.0	-0.034	-1000.0
HIF-2-alpha transcription factor network	9.0	407.0	43.0	-0.073	0.055	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	9.0	429.0	47.0	-0.16	0.04	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	8.0	648.0	74.0	-0.06	0.05	1000.0	-1000.0	-0.037	-1000.0
Arf6 signaling events	8.0	524.0	62.0	-0.071	0.075	1000.0	-1000.0	-0.012	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	8.0	652.0	74.0	-0.113	0.055	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PTP1B	7.0	593.0	76.0	-0.09	0.071	1000.0	-1000.0	-0.033	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	466.0	65.0	-0.152	0.079	1000.0	-1000.0	-0.028	-1000.0
Arf6 downstream pathway	7.0	309.0	43.0	-0.049	0.052	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	7.0	570.0	75.0	-0.083	0.051	1000.0	-1000.0	-0.06	-1000.0
VEGFR1 specific signals	7.0	427.0	56.0	-0.043	0.043	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in keratinocytes	7.0	312.0	43.0	-0.04	0.052	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling events	7.0	39.0	5.0	-0.004	0.031	1000.0	-1000.0	0.015	-1000.0
Coregulation of Androgen receptor activity	6.0	479.0	76.0	-0.19	0.059	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	170.0	28.0	-0.036	0.047	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	391.0	61.0	-0.118	0.073	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	6.0	287.0	44.0	-0.12	0.058	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	6.0	369.0	56.0	-0.074	0.085	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	6.0	305.0	48.0	-0.026	0.05	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	95.0	15.0	-0.025	0.035	1000.0	-1000.0	-0.034	-1000.0
Syndecan-3-mediated signaling events	6.0	219.0	35.0	-0.131	0.073	1000.0	-1000.0	-0.032	-1000.0
Integrins in angiogenesis	6.0	552.0	84.0	-0.102	0.071	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	310.0	45.0	-0.056	0.043	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	6.0	325.0	51.0	-0.118	0.077	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	6.0	24.0	4.0	0.0	0.006	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	469.0	76.0	-0.068	0.06	1000.0	-1000.0	-0.049	-1000.0
Plasma membrane estrogen receptor signaling	6.0	593.0	86.0	-0.057	0.053	1000.0	-1000.0	-0.044	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	800.0	136.0	-0.401	0.094	1000.0	-1000.0	-0.034	-1000.0
PLK2 and PLK4 events	5.0	16.0	3.0	-0.006	0.035	1000.0	-1000.0	-0.009	-1000.0
Visual signal transduction: Cones	5.0	215.0	38.0	-0.021	0.05	1000.0	-1000.0	-0.003	-1000.0
Cellular roles of Anthrax toxin	5.0	215.0	39.0	-0.052	0.036	1000.0	-1000.0	-0.021	-1000.0
p75(NTR)-mediated signaling	5.0	645.0	125.0	-0.129	0.088	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	248.0	46.0	-0.066	0.05	1000.0	-1000.0	-0.051	-1000.0
mTOR signaling pathway	5.0	285.0	53.0	-0.021	0.093	1000.0	-1000.0	-0.036	-1000.0
Nongenotropic Androgen signaling	5.0	302.0	52.0	-0.08	0.066	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	681.0	125.0	-0.035	0.042	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	5.0	113.0	22.0	-0.067	0.042	1000.0	-1000.0	-0.043	-1000.0
S1P3 pathway	5.0	251.0	42.0	-0.045	0.047	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Rods	5.0	279.0	52.0	-0.07	0.053	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	90.0	17.0	-0.01	0.037	1000.0	-1000.0	-0.019	-1000.0
Aurora B signaling	5.0	356.0	67.0	-0.099	0.059	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	4.0	298.0	65.0	-0.04	0.051	1000.0	-1000.0	-0.041	-1000.0
ErbB4 signaling events	4.0	276.0	69.0	-0.083	0.052	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	224.0	54.0	-0.058	0.052	1000.0	-1000.0	-0.036	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	353.0	85.0	-0.095	0.082	1000.0	-1000.0	-0.04	-1000.0
PLK1 signaling events	4.0	366.0	85.0	-0.028	0.104	1000.0	-1000.0	-0.041	-1000.0
Ceramide signaling pathway	4.0	333.0	76.0	-0.047	0.068	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	4.0	164.0	40.0	-0.065	0.066	1000.0	-1000.0	-0.028	-1000.0
S1P5 pathway	4.0	68.0	17.0	-0.007	0.036	1000.0	-1000.0	-0.006	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	224.0	52.0	-0.024	0.087	1000.0	-1000.0	-0.025	-1000.0
FoxO family signaling	4.0	293.0	64.0	-0.121	0.067	1000.0	-1000.0	-0.034	-1000.0
Retinoic acid receptors-mediated signaling	4.0	232.0	58.0	-0.056	0.067	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	4.0	256.0	58.0	-0.08	0.039	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	4.0	105.0	26.0	-0.069	0.067	1000.0	-1000.0	-0.01	-1000.0
Class I PI3K signaling events	4.0	329.0	73.0	-0.032	0.043	1000.0	-1000.0	-0.033	-1000.0
Insulin Pathway	4.0	298.0	74.0	-0.044	0.093	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	156.0	33.0	-0.068	0.079	1000.0	-1000.0	-0.018	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	578.0	120.0	-0.138	0.095	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	4.0	412.0	97.0	-0.059	0.089	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	4.0	117.0	25.0	-0.013	0.047	1000.0	-1000.0	-0.016	-1000.0
Regulation of Androgen receptor activity	4.0	296.0	70.0	-0.202	0.058	1000.0	-1000.0	-0.035	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.018	0.061	1000.0	-1000.0	-0.027	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	18.0	5.0	0.016	0.038	1000.0	-1000.0	0.019	-1000.0
EPO signaling pathway	3.0	165.0	55.0	-0.002	0.066	1000.0	-1000.0	-0.029	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	130.0	37.0	-0.035	0.064	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	3.0	167.0	49.0	-0.025	0.049	1000.0	-1000.0	-0.034	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	120.0	36.0	-0.051	0.067	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	3.0	111.0	31.0	-0.003	0.037	1000.0	-1000.0	-0.013	-1000.0
Regulation of Telomerase	3.0	373.0	102.0	-0.095	0.085	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	344.0	88.0	-0.044	0.041	1000.0	-1000.0	-0.066	-1000.0
LPA4-mediated signaling events	2.0	29.0	12.0	-0.016	0.055	1000.0	-1000.0	-0.025	-1000.0
Aurora A signaling	2.0	175.0	60.0	-0.01	0.061	1000.0	-1000.0	-0.012	-1000.0
Insulin-mediated glucose transport	2.0	72.0	32.0	-0.024	0.043	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	184.0	68.0	-0.044	0.073	1000.0	-1000.0	-0.028	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	181.0	82.0	-0.027	0.065	1000.0	-1000.0	-0.052	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	170.0	83.0	-0.024	0.066	1000.0	-1000.0	-0.017	-1000.0
Regulation of p38-alpha and p38-beta	2.0	122.0	54.0	-0.003	0.08	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	2.0	183.0	71.0	-0.036	0.042	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	2.0	88.0	44.0	-0.01	0.066	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	29.0	23.0	0.003	0.061	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	1.0	69.0	57.0	-0.051	0.079	1000.0	-1000.0	-0.038	-1000.0
Circadian rhythm pathway	1.0	36.0	22.0	-0.01	0.053	1000.0	-1000.0	-0.041	-1000.0
Ephrin A  reverse signaling	1.0	10.0	7.0	0.0	0.034	1000.0	-1000.0	0.0	-1000.0
Signaling events mediated by HDAC Class I	1.0	194.0	104.0	-0.047	0.085	1000.0	-1000.0	-0.028	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	34.0	27.0	0.0	0.072	1000.0	-1000.0	-0.03	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.0	0.049	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by PRL	1.0	58.0	34.0	-0.026	0.052	1000.0	-1000.0	-0.025	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.031	0.031	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	1.0	21.0	13.0	-0.0	0.081	1000.0	-1000.0	-0.0	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	31.0	34.0	-0.045	0.072	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	0.0	29.0	39.0	-0.0	0.074	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class II	0.0	73.0	75.0	-0.041	0.067	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.06	1000.0	-1000.0	-0.01	-1000.0
Effects of Botulinum toxin	0.0	20.0	26.0	-0.005	0.059	1000.0	-1000.0	-0.003	-1000.0
Arf1 pathway	0.0	44.0	54.0	-0.002	0.048	1000.0	-1000.0	-0.014	-1000.0
Total	938	58564	7203	-11.9078446202	8.28825829312	131000	-131000	-4.02220306759	-131000