rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM2(3), CALML6(3), CDS1(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), IMPA1(3), IMPA2(5), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPP5B(4), INPP5D(9), INPPL1(14), ITPK1(2), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), OCRL(15), PI4KA(9), PI4KB(6), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3C3(9), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PRKCA(7), PRKCG(6), PTEN(208), PTPMT1(1), SYNJ1(24), SYNJ2(8)	43792584	1019	212	833	215	215	262	191	47	215	89	<1.00e-15	<9.78e-15
2	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGAP1(2), ARHGAP4(8), ARHGEF11(18), BTK(4), CDC42(4), CFL1(1), CFL2(7), GDI1(4), GDI2(1), INPPL1(14), ITPR1(23), ITPR2(25), ITPR3(15), LIMK1(6), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3CG(18), PIK3R1(106), PITX2(9), PPP1R13B(5), PTEN(208), RACGAP1(7), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), SAG(4), WASF1(3), WASL(7)	25519200	746	209	565	117	155	155	137	32	178	89	<1.00e-15	<9.78e-15
3	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(4), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), MKNK1(3), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), PTEN(208), RPS6(6), RPS6KB1(2), TSC1(9), TSC2(13)	9352328	550	208	375	33	88	81	114	25	157	85	<1.00e-15	<9.78e-15
4	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(3), AKT2(4), AKT3(7), BRD4(7), CAP1(7), CBL(8), CDC42(4), CDKN2A(1), F2RL2(2), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), IGFBP1(4), INPPL1(14), IRS1(10), IRS4(16), LNPEP(6), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PPYR1(6), PTEN(208), PTPN1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SERPINB6(2), SHC1(5), SLC2A4(5), SORBS1(14), SOS1(10), SOS2(16), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	20890280	712	208	527	94	136	135	150	29	175	87	<1.00e-15	<9.78e-15
5	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), GHR(8), IRS1(10), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(8), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PRKCA(7), PTEN(208), RPS6KB1(2)	10285800	555	206	380	37	85	76	123	28	158	85	<1.00e-15	<9.78e-15
6	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(9), AKT1(3), AKT2(4), AKT3(7), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CSF2RB(9), CYCS(2), DFFB(3), FAS(6), FASLG(5), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL3RA(8), IRAK1(4), IRAK2(5), IRAK3(7), IRAK4(5), MAP3K14(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), NTRK1(11), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), RIPK1(8), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF1A(4), TP53(48), TRAF2(2)	29073536	679	206	554	120	151	194	109	39	145	41	<1.00e-15	<9.78e-15
7	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4E(2), GSK3B(8), IGF1(2), IGF1R(10), INPPL1(14), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), PTEN(208), RPS6(6), RPS6KB1(2)	7229448	526	206	350	35	83	68	111	21	158	85	<1.00e-15	<9.78e-15
8	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(3), CRK(1), CRKL(4), DOCK1(17), ELK1(2), FOS(2), GAB1(5), GRB2(3), HGF(13), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAP4K1(9), MAPK1(2), MAPK3(3), MAPK8(7), MET(9), PAK1(1), PIK3CA(142), PIK3R1(106), PTEN(208), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAF1(5), RAP1A(3), RAP1B(2), RASA1(23), SOS1(10), SRC(2), STAT3(8)	16040640	641	205	462	67	116	112	130	27	171	85	<1.00e-15	<9.78e-15
9	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(3), CDKN1B(6), GRB2(3), ILK(4), ITGB1(5), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PTEN(208), PTK2(8), SHC1(5), SOS1(10)	6596056	510	203	333	25	74	64	114	22	151	85	<1.00e-15	<9.78e-15
10	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(5), CDKN2A(1), E2F1(6), MDM2(3), MYC(6), PIK3CA(142), PIK3R1(106), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), RAC1(1), RB1(23), TBX2(2), TP53(48)	7272352	367	198	251	40	83	72	66	25	80	41	<1.00e-15	<9.78e-15
11	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(3), AKT2(4), AKT3(7), BAD(2), BTK(4), CDKN2A(1), DAPP1(7), GRB2(3), GSK3A(8), GSK3B(8), IARS(7), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(142), PPP1R13B(5), PTEN(208), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SOS1(10), SOS2(16), TEC(5), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	13060672	503	198	342	50	104	98	116	23	112	50	<1.00e-15	<9.78e-15
12	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(4), AKT3(7), BCR(4), BTK(4), CD19(3), CDKN2A(1), DAPP1(7), FLOT2(1), GAB1(5), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PIK3CA(142), PITX2(9), PLCG2(23), PPP1R13B(5), PREX1(17), PTEN(208), PTPRC(11), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SAG(4), SYK(3), TEC(5), VAV1(10)	20136112	584	197	426	96	125	135	123	27	124	50	<1.00e-15	<9.78e-15
13	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(3), APC(36), AXIN1(7), CCND1(12), CD14(2), CTNNB1(63), FZD1(3), GJA1(5), GNAI1(4), GSK3B(8), IRAK1(4), LBP(2), LEF1(8), LY96(3), MYD88(1), NFKB1(7), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), RELA(4), TIRAP(2), TLR4(13), WNT1(1)	10269432	442	196	293	36	92	113	77	34	85	41	<1.00e-15	<9.78e-15
14	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(11), ATM(42), ATR(26), BAI1(6), BAX(3), BID(2), CASP3(3), CASP8(12), CASP9(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNG1(6), CCNG2(2), CD82(2), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), CYCS(2), DDB2(3), EI24(3), FAS(6), GTSE1(1), IGF1(2), IGFBP3(3), MDM2(3), PERP(3), PMAIP1(1), PPM1D(9), PTEN(208), RCHY1(3), RFWD2(4), RRM2(5), RRM2B(4), SERPINE1(5), SESN1(4), SESN2(2), SESN3(13), SIAH1(3), STEAP3(4), THBS1(9), TNFRSF10B(4), TP53(48), TP53I3(4), TSC2(13), ZMAT3(8)	21514496	573	195	479	103	90	141	98	29	159	56	<1.00e-15	<9.78e-15
15	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	AKT1(3), AKT2(4), AKT3(7), CASP8(12), CCL4(1), CCL5(2), CD14(2), CD40(2), CD80(5), CD86(4), CHUK(7), CXCL10(2), CXCL9(2), FOS(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IKBKB(8), IKBKE(1), IL12A(5), IL12B(2), IL1B(2), IL6(4), IL8(3), IRAK1(4), IRAK4(5), IRF3(2), IRF5(5), JUN(1), LBP(2), LY96(3), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K7(8), MAP3K8(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), RAC1(1), RELA(4), RIPK1(8), SPP1(2), STAT1(12), TBK1(5), TICAM1(6), TICAM2(4), TIRAP(2), TLR1(10), TLR2(11), TLR3(5), TLR4(13), TLR5(6), TLR6(9), TLR7(12), TLR8(16), TLR9(5), TRAF3(4), TRAF6(3)	31180048	664	195	552	124	153	197	119	35	121	39	<1.00e-15	<9.78e-15
16	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(4), AKT3(7), BPNT1(1), GRB2(3), ILK(4), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(142), PIK3CD(9), PTEN(208), PTK2B(13), RBL2(15), SHC1(5), SOS1(10)	7240112	431	194	271	30	84	73	103	20	100	51	<1.00e-15	<9.78e-15
17	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(7), AKT1(3), CALM2(3), CALR(1), CAMK1(2), CAMK1G(3), CAMK4(3), CREBBP(24), CSNK1A1(4), EDN1(2), ELSPBP1(4), F2(8), GATA4(1), GSK3B(8), HAND1(5), IGF1(2), LIF(2), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MEF2C(8), MYH2(31), NFATC2(9), NFATC3(9), NFATC4(7), NPPA(1), PIK3CA(142), PIK3R1(106), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RAF1(5), RPS6KB1(2), SYT1(4)	17612464	459	192	350	61	102	116	86	25	93	37	<1.00e-15	<9.78e-15
18	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	46	ACOX1(3), APOA2(1), CD36(5), CPT1B(1), CREBBP(24), DUSP1(2), EHHADH(4), EP300(23), FABP1(4), HSD17B4(8), JUN(1), LPL(9), MAPK1(2), MAPK3(3), ME1(7), MRPL11(1), MYC(6), NCOA1(15), NCOR1(16), NCOR2(16), NFKBIA(2), NR0B2(2), NR1H3(4), NR2F1(5), NRIP1(14), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PTGS2(6), RB1(23), RELA(4), RXRA(1), SP1(6), SRA1(1), STAT5A(2), STAT5B(3)	21371152	500	192	392	75	104	134	95	29	95	43	<1.00e-15	<9.78e-15
19	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(36), AR(4), ASAH1(6), BRAF(9), CCL13(2), CCL15(1), CCL16(1), DAG1(4), EGFR(10), GNA11(2), GNA15(1), GNAI1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), MAPK10(7), MAPK14(4), PHKA2(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PITX2(9), PTX3(1), RAF1(5), SRC(2)	19109640	470	192	365	85	106	121	89	20	89	45	<1.00e-15	<9.78e-15
20	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(3), AKT2(4), AKT3(7), BRAF(9), CAB39(6), DDIT4(2), EIF4B(5), FIGF(5), HIF1A(12), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(2), PGF(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PRKAA1(5), PRKAA2(7), RHEB(2), RICTOR(20), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), TSC1(9), TSC2(13), ULK2(7), ULK3(5), VEGFB(2), VEGFC(6)	17006352	500	191	390	69	121	125	90	30	97	37	<1.00e-15	<9.78e-15
21	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	37	AKT1(3), ASAH1(6), ATF1(4), BRAF(9), CREB1(5), CREB5(3), CREBBP(24), CRKL(4), DAG1(4), EGR1(6), EGR2(4), EGR3(5), ELK1(2), FRS2(4), JUN(1), MAP1B(27), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), NTRK1(11), OPN1LW(4), PIK3C2G(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PTPN11(5), RPS6KA3(15), SHC1(5), SRC(2), TERF2IP(2)	16678248	455	190	349	70	101	126	82	23	81	42	<1.00e-15	<9.78e-15
22	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(12), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(6), E2F1(6), MAPK1(2), MAPK3(3), NFKB1(7), NFKBIA(2), PAK1(1), PIK3CA(142), PIK3R1(106), RAC1(1), RAF1(5), RB1(23), RELA(4)	7277312	332	189	227	24	63	66	71	18	73	41	<1.00e-15	<9.78e-15
23	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(12), ARHGEF1(9), F2(8), F2R(6), GNA12(7), GNA13(7), GNAI1(4), GNB1(1), MAP3K7(8), PIK3CA(142), PIK3R1(106), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2B(13), ROCK1(15)	9135576	360	188	255	39	91	75	71	19	63	41	<1.00e-15	<9.78e-15
24	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(3), CD3D(3), CD3E(1), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(3), JUN(1), LCK(3), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PIK3CA(142), PIK3R1(106), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), PTPN7(4), RAC1(1), RAF1(5), RASA1(23), RELA(4), SHC1(5), SOS1(10), SYT1(4), VAV1(10), ZAP70(6)	17029912	445	188	336	52	106	97	81	27	95	39	<1.00e-15	<9.78e-15
25	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(3), CABIN1(11), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(10), IGF1(2), IGF1R(10), INSR(12), MAP2K6(6), MAPK14(4), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), NFATC2(9), PIK3CA(142), PIK3R1(106), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYT1(4), YWHAH(2)	11733376	371	187	268	51	77	93	71	20	73	37	<1.00e-15	<9.78e-15
26	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(3), AKT2(4), AKT3(7), BAD(2), GRB2(3), GSK3A(8), GSK3B(8), IL4R(5), IRS1(10), JAK1(16), JAK3(5), MAP4K1(9), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PPP1R13B(5), RAF1(5), SHC1(5), SOS1(10), SOS2(16), STAT6(5)	12682224	390	187	281	43	83	95	81	20	72	39	<1.00e-15	<9.78e-15
27	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(12), AKT1(3), BAD(2), BAX(3), BCL2L1(3), CSF2RB(9), IGF1(2), IGF1R(10), IL3RA(8), KIT(22), KITLG(2), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), YWHAH(2)	7605912	347	186	243	37	77	80	66	20	67	37	<1.00e-15	<9.78e-15
28	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(12), AKT1(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), GNAS(16), GRB2(3), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAC1(1), RPS6KA1(1), RPS6KA5(7), SOS1(10)	9949016	357	186	249	38	74	82	68	22	74	37	<1.00e-15	<9.78e-15
29	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(12), AKT1(3), ASAH1(6), GNAI1(4), GNB1(1), ITGAV(6), ITGB3(10), MAPK1(2), MAPK3(3), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLCB1(4), PRKCA(7), PTK2(8), RAC1(1), SMPD1(10), SMPD2(4), SPHK1(2), SRC(2)	9720112	352	186	247	43	67	81	72	21	72	39	<1.00e-15	<9.78e-15
30	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CDK5R1(2), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(24), MYL2(1), MYLK(10), NCF2(4), PAK1(1), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLD1(9), PPP1R12B(11), RAC1(1), RALBP1(4), RPS6KB1(2), TRIO(25), VAV1(10), WASF1(3)	12860784	384	186	276	46	88	83	69	22	81	41	<1.00e-15	<9.78e-15
31	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(5), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), NTRK1(11), PIK3CA(142), PIK3R1(106), PLCG1(8), RPS6KA1(1), SHC1(5)	6784536	317	185	213	26	67	70	62	17	64	37	<1.00e-15	<9.78e-15
32	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(5), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(7), PIK3CA(142), PIK3R1(106), RB1(23), RELA(4), SP1(6)	7032288	344	185	239	21	67	69	73	22	70	43	<1.00e-15	<9.78e-15
33	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(2), BCL2L1(3), CBL(8), CFLAR(5), CRKL(4), E2F1(6), FOS(2), GRB2(3), IL2RA(2), IL2RB(1), IL2RG(11), IRS1(10), JAK1(16), JAK3(5), MAPK1(2), MAPK3(3), MYC(6), NMI(1), PIK3CA(142), PIK3R1(106), PPIA(1), RAF1(5), RPS6KB1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3)	12924520	372	185	267	41	81	94	72	20	68	37	<1.00e-15	<9.78e-15
34	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), INSR(12), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PTPN11(5), RAF1(5), RASA1(23), SHC1(5), SLC2A4(5), SOS1(10), SRF(2)	9064400	352	185	245	28	79	77	68	19	72	37	<1.00e-15	<9.78e-15
35	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2)	12553264	420	185	309	40	94	91	79	29	86	41	<1.00e-15	<9.78e-15
36	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(2), CASP9(2), CHUK(7), GH1(2), GHR(8), NFKB1(7), NFKBIA(2), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), RELA(4), YWHAH(2)	5225112	293	184	190	11	60	53	64	17	62	37	<1.00e-15	<9.78e-15
37	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(18), DIAPH1(10), FYN(6), GSN(4), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PFN1(1), PIK3CA(142), PIK3R1(106), PTK2(8), PXN(4), RAF1(5), ROCK1(15), SHC1(5), SRC(2), TLN1(20)	13822280	382	184	279	32	89	88	72	19	73	41	<1.00e-15	<9.78e-15
38	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(7), EGF(17), EGFR(10), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2)	13610736	428	184	317	47	95	96	81	28	89	39	<1.00e-15	<9.78e-15
39	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(4), CALM2(3), ELK1(2), FCER1A(7), FCER1G(1), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PAK2(3), PIK3CA(142), PIK3R1(106), PLA2G4A(9), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10)	15068480	412	184	304	48	108	82	76	25	82	39	<1.00e-15	<9.78e-15
40	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(4), CRKL(4), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), MYC(6), PIK3CA(142), PIK3R1(106), RAF1(5), SOS1(10), STAT1(12), STAT5A(2), STAT5B(3)	9895944	357	184	250	28	80	72	70	22	70	43	<1.00e-15	<9.78e-15
41	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IGF1(2), IGF1R(10), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PTPN11(5), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2)	8891792	347	184	240	26	77	72	69	20	72	37	<1.00e-15	<9.78e-15
42	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(24), EP300(23), FYN(6), IL2RG(11), IL7(1), IL7R(7), JAK1(16), JAK3(5), LCK(3), NMI(1), PIK3CA(142), PIK3R1(106), PTK2B(13), STAT5A(2), STAT5B(3)	10000600	363	184	258	44	78	83	69	18	78	37	<1.00e-15	<9.78e-15
43	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(2), CHRNB1(2), CHRNG(2), MUSK(11), PIK3CA(142), PIK3R1(106), PTK2(8), PTK2B(13), RAPSN(1), SRC(2), TERT(3), YWHAH(2)	5636544	297	183	194	32	66	56	62	17	59	37	<1.00e-15	<9.78e-15
44	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(2), BCL2L1(3), CASP9(2), CDC42(4), CHUK(7), ELK1(2), H2AFX(1), MAP2K1(2), MAPK3(3), NFKB1(7), PIK3CA(142), PIK3R1(106), RAC1(1), RAF1(5), RALA(3), RALBP1(4), RALGDS(9), RELA(4), RHOA(3)	6754776	313	183	208	17	64	66	67	15	64	37	<1.00e-15	<9.78e-15
45	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	27	DUSP1(2), GORASP1(7), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK5(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), SYT1(4), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3)	10022672	351	183	247	32	73	84	66	17	72	39	<1.00e-15	<9.78e-15
46	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(5), AKT1(3), ANXA1(4), CALM2(3), GNAS(16), GNB1(1), NFKB1(7), NOS3(6), NPPA(1), NR3C1(11), PIK3CA(142), PIK3R1(106), RELA(4), SYT1(4)	6103280	313	182	208	17	70	62	64	14	66	37	<1.00e-15	<9.78e-15
47	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(8), GRB2(3), INSR(12), IRS1(10), JAK2(14), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RPS6KA1(1), SHC1(5), SLC2A4(5), SOS1(10), SRF(2), STAT5A(2), STAT5B(3)	11804056	352	182	246	42	76	76	74	20	65	41	<1.00e-15	<9.78e-15
48	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(2), GRB2(3), IGF1R(10), IRS1(10), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(142), PIK3R1(106), RAF1(5), SHC1(5), SOS1(10), YWHAH(2)	6863896	305	182	200	24	62	62	66	17	61	37	<1.00e-15	<9.78e-15
49	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(3), GH1(2), GHR(8), IGF1(2), IGF1R(10), PIK3CA(142), PIK3R1(106), SHC1(5), SOD1(2), SOD2(3)	4733576	286	182	183	20	57	53	62	17	60	37	<1.00e-15	<9.78e-15
50	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(2), GRB2(3), KLK2(2), NTRK1(11), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), SHC1(5), SOS1(10)	5679448	299	182	193	24	65	59	61	18	59	37	<1.00e-15	<9.78e-15
51	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), PAK1(1), PDGFRA(19), PIK3CA(142), PIK3R1(106), RAC1(1), WASL(7)	4950824	296	181	192	11	62	55	61	15	64	39	<1.00e-15	<9.78e-15
52	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(7), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MPL(4), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), THPO(5)	10901088	372	181	263	38	82	80	75	21	73	41	<1.00e-15	<9.78e-15
53	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	CRK(1), CXCL12(2), CXCR4(1), GNAI1(4), GNB1(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(7), PIK3C2G(12), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), PTK2(8), PTK2B(13), PXN(4), RAF1(5), RELA(4)	9670512	332	180	228	40	73	66	71	19	66	37	<1.00e-15	<9.78e-15
54	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(1), IL18(1), ITGB1(5), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), MAP2K1(2), MAPK3(3), PAK1(1), PIK3CA(142), PIK3R1(106), PTK2B(13), RAC1(1), SYK(3), VAV1(10)	6800160	299	180	196	22	66	54	62	17	63	37	<1.00e-15	<9.78e-15
55	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(142), PIK3R1(106), PLCB1(4), PLCG1(8), PRKCA(7), VAV1(10)	4726136	280	180	176	27	59	46	61	17	60	37	<1.00e-15	<9.78e-15
56	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(1), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), ELAVL1(6), FLT1(15), FLT4(9), HIF1A(12), KDR(20), NOS3(6), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), PTK2(8), PXN(4), SHC1(5), VHL(2)	11492816	381	180	276	46	88	87	69	22	78	37	<1.00e-15	<9.78e-15
57	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(3), CD3D(3), CD3E(1), CD3G(1), CD80(5), CD86(4), CTLA4(2), GRB2(3), ICOS(2), IL2(2), ITK(5), LCK(3), PIK3CA(142), PIK3R1(106), PTPN11(5)	4727872	287	179	184	15	61	53	61	14	61	37	<1.00e-15	<9.78e-15
58	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(7), DPM2(2), ELK1(2), FOS(2), GRB2(3), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(7), NGFR(3), PIK3CA(142), PIK3R1(106), PLCG1(8), RAF1(5), SHC1(5), SOS1(10)	6872824	310	178	203	15	70	59	65	18	61	37	<1.00e-15	<9.78e-15
59	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(4), AKT3(7), CDKN1A(1), ELK1(2), GRB2(3), MAP2K1(2), NGFR(3), NTRK1(11), PIK3CA(142), PIK3CD(9), SHC1(5), SOS1(10)	5439136	202	130	118	19	64	58	53	15	12	0	<1.00e-15	<9.78e-15
60	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTNNB1(63), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1)	19346728	277	109	232	67	64	128	29	22	32	2	<1.00e-15	<9.78e-15
61	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTNNB1(63), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1)	19346728	277	109	232	67	64	128	29	22	32	2	<1.00e-15	<9.78e-15
62	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(42), CCNA1(3), CCNB1(7), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNG2(2), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(5), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), GBA2(9), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MYC(6), NACA(17), PCNA(2), POLA2(1), POLE2(2), PRIM1(2), RB1(23), RBL1(13), RPA1(5), RPA2(2), RPA3(3), TFDP2(5), TNXB(16), TP53(48), WEE1(1)	27461536	330	108	310	77	81	120	41	21	59	8	<1.00e-15	<9.78e-15
63	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(42), ATR(26), BRCA1(14), CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(11), EP300(23), MDM2(3), PRKDC(40), RPS6KA1(1), TP53(48), WEE1(1), YWHAH(2), YWHAQ(1)	15684512	237	87	219	49	46	73	41	18	55	4	<1.00e-15	<9.78e-15
64	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(8), BID(2), BRAF(9), CASP3(3), CD244(3), CD247(3), CD48(1), FAS(6), FASLG(5), FCER1G(1), FCGR3A(1), FCGR3B(1), FYN(6), GRB2(3), GZMB(2), HCST(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), ITGAL(12), ITGB2(10), KIR2DL1(4), KIR2DL4(2), KIR3DL1(6), KIR3DL2(3), KLRC1(2), KLRC2(3), KLRC3(1), KLRD1(1), KLRK1(1), KRAS(27), LCK(3), LCP2(4), MAP2K1(2), MAPK1(2), MAPK3(3), MICB(2), NCR1(5), NCR2(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NRAS(8), PAK1(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRF1(6), PRKCA(7), PRKCG(6), PTK2B(13), PTPN11(5), RAC1(1), RAC2(2), RAF1(5), SH2D1A(3), SH2D1B(2), SH3BP2(7), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SYK(3), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), ULBP1(2), ULBP2(4), VAV1(10), VAV2(3), VAV3(9), ZAP70(6)	39412408	759	198	622	160	203	221	137	42	115	41	1.67e-15	1.60e-14
65	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(11), ATM(42), BAX(3), CCND1(12), CDK2(2), CDK4(3), CDKN1A(1), E2F1(6), MDM2(3), PCNA(2), RB1(23), TIMP3(8), TP53(48)	6526120	164	86	147	27	41	43	24	8	40	8	2.00e-15	1.89e-14
66	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CSK(1), DAG1(4), EPHB2(8), GRB2(3), ITPKB(7), LYN(6), MAP2K1(2), MAPK1(2), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PI3(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLCG2(23), PPP1R13B(5), RAF1(5), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10)	18046712	438	186	330	82	105	111	84	24	75	39	2.33e-15	2.18e-14
67	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(3), AKT2(4), AKT3(7), ANKRD6(6), APC(36), AXIN1(7), CER1(2), CSNK1A1(4), CTNNB1(63), DACT1(10), DKK1(3), DKK2(3), DKK3(1), DKK4(3), FSTL1(2), GSK3A(8), GSK3B(8), LRP1(36), MVP(11), NKD1(3), PSEN1(5), PTPRA(7), SENP2(6), SFRP1(5), TSHB(3), WIF1(4)	13849312	250	105	201	58	71	103	30	21	21	4	2.55e-15	2.35e-14
68	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(42), ATR(26), CDC25C(5), CHEK1(2), CHEK2(11), TP53(48), YWHAH(2)	5967624	136	75	121	17	30	40	18	10	34	4	2.78e-15	2.51e-14
69	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), DAG1(4), DGKA(9), ETFA(4), GCA(2), ITGA9(13), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(5), PAK1(1), PDE3A(14), PDE3B(9), PI3(2), PIK3C2G(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLDN(3), PSME1(1), RIPK3(2), RPS4X(1), SGCB(3), VASP(1)	17827976	433	187	328	79	94	110	87	17	86	39	3.33e-15	2.89e-14
70	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(11), BAD(2), BAK1(3), BAX(3), BCL2L1(3), BCL2L11(5), BID(2), BIRC2(10), BIRC3(2), BIRC5(4), BNIP3L(1), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CHUK(7), CYCS(2), DFFB(3), FAS(6), FASLG(5), GZMB(2), HELLS(8), IKBKB(8), IRF1(1), IRF2(6), IRF3(2), IRF4(6), IRF5(5), IRF6(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(24), MAPK10(7), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), NFKBIE(5), PLEKHG5(5), PRF1(6), RELA(4), RIPK1(8), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TP53(48), TRAF1(5), TRAF2(2), TRAF3(4)	19716992	317	100	298	75	76	115	36	21	65	4	3.33e-15	2.89e-14
71	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(4), IFNG(5), IFNGR1(5), IFNGR2(3), IKBKB(8), JAK2(14), LIN7A(6), NFKB1(7), NFKBIA(2), RB1(23), RELA(4), TNFRSF1A(4), TNFRSF1B(1), TP53(48), USH1C(9), WT1(2)	6436592	145	74	132	34	33	43	23	7	31	8	3.33e-15	2.89e-14
72	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), CREB3L1(3), CREB3L2(4), CREB3L3(7), CREB3L4(5), CREBBP(24), CTNNB1(63), DCT(11), DVL2(5), DVL3(7), EDN1(2), EP300(23), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GSK3B(8), KIT(22), KITLG(2), KRAS(27), LEF1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MITF(3), NRAS(8), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), TCF7(3), TCF7L1(2), TCF7L2(10), TYR(8), TYRP1(7), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1)	36286616	567	147	485	182	155	218	88	41	65	0	3.77e-15	3.23e-14
73	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(36), AXIN1(7), CREBBP(24), CTNNB1(63), EP300(23), FZD1(3), GSK3B(8), HDAC1(3), LDB1(2), LEF1(8), PITX2(9), TRRAP(32), WNT1(1)	11299872	219	109	171	55	45	88	29	21	30	6	3.89e-15	3.28e-14
74	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(4), AKT3(7), BCL10(2), CARD11(13), CBL(8), CBLB(11), CBLC(4), CD247(3), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD40LG(5), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(7), CTLA4(2), FOS(2), FYN(6), GRB2(3), ICOS(2), IFNG(5), IKBKB(8), IL10(2), IL2(2), IL5(1), ITK(5), JUN(1), KRAS(27), LCK(3), LCP2(4), MALT1(3), MAP3K14(4), MAP3K8(6), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NRAS(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCQ(6), PTPRC(11), RASGRP1(6), RHOA(3), SOS1(10), SOS2(16), TEC(5), VAV1(10), VAV2(3), VAV3(9), ZAP70(6)	35340000	693	196	559	140	185	187	128	39	115	39	4.11e-15	3.42e-14
75	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(5), ACTN1(7), ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGEF6(16), ARHGEF7(11), BRAF(9), CDC42(4), CDKN2A(1), CRK(1), CSE1L(10), DOCK1(17), EPHB2(8), FYN(6), GRB2(3), GRB7(4), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP3K11(5), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MRAS(1), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CA(142), PIK3CB(13), PKLR(5), PLCG1(8), PLCG2(23), PTEN(208), PTK2(8), RAF1(5), RALA(3), RHO(3), ROCK1(15), ROCK2(10), SHC1(5), SOS1(10), SOS2(16), SRC(2), TERF2IP(2), TLN1(20), TLN2(20), VASP(1), WAS(8), ZYX(11)	42913424	853	203	683	164	191	226	169	43	170	54	4.22e-15	3.42e-14
76	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(3), AKT2(4), AKT3(7), BTK(4), FCER1A(7), FCER1G(1), FYN(6), GAB2(8), GRB2(3), IL5(1), INPP5D(9), KRAS(27), LCP2(4), LYN(6), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MS4A2(2), NRAS(8), PDK1(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCD(4), PRKCE(7), RAC1(1), RAC2(2), RAF1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10), VAV2(3), VAV3(9)	24451560	594	195	460	105	153	158	113	33	96	41	4.22e-15	3.42e-14
77	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(9), ACVR1B(5), ACVRL1(1), AKT1(3), AURKB(3), BMPR1A(4), BMPR2(9), BUB1(7), CDKL1(6), CDKL2(5), CDS1(4), CLK1(7), CLK2(7), CLK4(5), CSNK2A1(7), CSNK2A2(3), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), IMPA1(3), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPPL1(14), ITPKB(7), MAP3K10(6), MOS(6), NEK1(17), NEK3(6), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CA(142), PIK3CB(13), PIK3CG(18), PIM2(3), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23), PLK3(7), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKG1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KB1(2), TGFBR1(3), VRK1(10)	40126152	674	169	578	185	196	223	122	42	89	2	4.44e-15	3.50e-14
78	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(7), DNAJC3(5), EIF2S2(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), TP53(48)	3536976	82	61	69	9	20	23	11	7	21	0	4.44e-15	3.50e-14
79	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(4), AKT3(7), CISH(1), GRB2(3), IARS(7), IL13RA1(10), IL2RG(11), IL4R(5), INPP5D(9), JAK1(16), JAK2(14), JAK3(5), NR0B2(2), PI3(2), PIK3CA(142), PPP1R13B(5), RPS6KB1(2), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT6(5), TYK2(4)	13315864	294	135	209	53	79	91	71	19	28	6	4.55e-15	3.50e-14
80	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCL2L1(3), CDC42(4), CDK2(2), CDKN1B(6), CDKN2A(1), CREB1(5), CREB5(3), ERBB4(19), F2RL2(2), GAB1(5), GRB2(3), GSK3A(8), GSK3B(8), IGF1(2), IGFBP1(4), INPPL1(14), IRS1(10), IRS4(16), MET(9), MYC(6), NOLC1(10), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARD3(19), PDK1(2), PIK3CA(142), PIK3CD(9), PPP1R13B(5), PREX1(17), PTEN(208), PTK2(8), PTPN1(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SLC2A4(5), SOS1(10), SOS2(16), TSC1(9), TSC2(13), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	26511696	694	202	531	117	141	175	154	35	139	50	4.66e-15	3.50e-14
81	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	231	ACVR1B(5), ACVR1C(3), AKT1(3), AKT2(4), AKT3(7), ARRB1(4), ARRB2(3), ATF2(6), ATF4(3), BDNF(6), BRAF(9), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CACNA2D1(9), CACNA2D2(8), CACNA2D3(17), CACNA2D4(13), CACNB1(7), CACNB2(9), CACNB3(4), CACNB4(11), CACNG2(2), CACNG3(8), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CASP3(3), CD14(2), CDC25B(2), CDC42(4), CHUK(7), CRK(1), CRKL(4), DAXX(6), DDIT3(1), DUSP1(2), DUSP10(5), DUSP14(3), DUSP16(8), DUSP3(1), DUSP5(3), DUSP6(1), DUSP7(3), DUSP9(1), ECSIT(3), EGF(17), EGFR(10), ELK1(2), ELK4(2), FAS(6), FASLG(5), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR2(27), FGFR4(8), FLNA(27), FLNB(28), FLNC(27), FOS(2), GNA12(7), GNG12(1), GRB2(3), IKBKB(8), IL1B(2), IL1R1(4), IL1R2(5), JUN(1), KRAS(27), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAPT(9), MAX(4), MEF2C(8), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(6), NF1(30), NFATC2(9), NFATC4(7), NFKB1(7), NFKB2(9), NLK(5), NR4A1(4), NRAS(8), NTF3(4), NTRK1(11), NTRK2(11), PAK1(1), PAK2(3), PDGFB(2), PDGFRA(19), PDGFRB(10), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PPM1A(6), PPM1B(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(4), PTPRR(13), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF2(26), RASA1(23), RASA2(7), RASGRF1(8), RASGRF2(11), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KA6(12), RRAS(1), RRAS2(4), SOS1(10), SOS2(16), SRF(2), STK3(7), STK4(5), STMN1(4), TAOK1(9), TAOK2(6), TAOK3(3), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF1A(4), TP53(48), TRAF2(2), TRAF6(3), ZAK(11)	99014000	1474	182	1392	429	400	564	185	104	201	20	4.77e-15	3.50e-14
82	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), FAS(6), FASLG(5), GZMB(2), JUN(1), MAP2K4(4), MAP3K1(24), MAP3K14(4), MAPK10(7), MCL1(1), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), PARP1(9), PRF1(6), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TP53(48), TRAF1(5), TRAF2(2)	13230800	223	89	206	48	57	69	31	20	42	4	4.77e-15	3.50e-14
83	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(5), ATM(42), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(11), JUN(1), MAPK8(7), MDM2(3), MRE11A(9), NFKB1(7), NFKBIA(2), RAD50(15), RAD51(2), RBBP8(8), RELA(4), TP53(48)	10615640	181	83	166	37	37	59	26	12	41	6	4.77e-15	3.50e-14
84	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	AKT1(3), AKT2(4), AKT3(7), BAD(2), CASP9(2), CDC42(4), KDR(20), KRAS(27), MAP2K1(2), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPKAPK2(4), MAPKAPK3(2), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NOS3(6), NRAS(8), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCA(7), PRKCG(6), PTGS2(6), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), SPHK1(2), SPHK2(1), SRC(2)	23650768	560	192	429	97	147	146	104	32	94	37	4.88e-15	3.50e-14
85	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(9), APC(36), ATF2(6), AXIN1(7), BMP10(7), BMP2(5), BMP4(7), BMP5(12), BMP7(10), BMPR1A(4), BMPR2(9), CHRD(8), CTNNB1(63), FZD1(3), GATA4(1), GSK3B(8), MAP3K7(8), MEF2C(8), MYL2(1), NOG(2), NPPA(1), NPPB(2), RFC1(13), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), WNT1(1)	12350648	263	108	214	44	63	120	32	19	25	4	4.88e-15	3.50e-14
86	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(3), MAX(4), MYC(6), SP1(6), SP3(8), TP53(48), WT1(2)	2524640	77	61	64	10	19	27	7	5	17	2	4.88e-15	3.50e-14
87	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	193	ABI2(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), APC(36), ARAF(8), ARHGEF1(9), ARHGEF12(19), ARHGEF4(5), ARHGEF6(16), ARHGEF7(11), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), ARPC5(1), BDKRB1(2), BDKRB2(7), BRAF(9), CD14(2), CDC42(4), CFL1(1), CFL2(7), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CRK(1), CRKL(4), CSK(1), CYFIP1(7), CYFIP2(17), DIAPH1(10), DIAPH2(18), DIAPH3(24), DOCK1(17), EGF(17), EGFR(10), EZR(4), F2(8), F2R(6), FGD1(10), FGD3(8), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR2(27), FGFR4(8), FN1(31), GIT1(8), GNA12(7), GNA13(7), GNG12(1), GSN(4), IQGAP1(9), IQGAP2(21), IQGAP3(15), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), KRAS(27), LIMK1(6), LIMK2(10), MAP2K1(2), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(12), MYH10(23), MYH14(17), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), NCKAP1(6), NCKAP1L(13), NRAS(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDGFB(2), PDGFRA(19), PDGFRB(10), PFN1(1), PFN2(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R12B(11), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RDX(11), RHOA(3), ROCK1(15), ROCK2(10), RRAS(1), RRAS2(4), SCIN(3), SLC9A1(6), SOS1(10), SOS2(16), SSH1(10), SSH2(7), SSH3(3), TIAM1(20), TIAM2(14), VAV1(10), VAV2(3), VAV3(9), VCL(8), WAS(8), WASF1(3), WASF2(3), WASL(7)	96510688	1561	213	1392	423	398	543	246	92	225	57	5.11e-15	3.57e-14
88	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ARHGAP5(18), CD99(1), CDC42(4), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTNND1(17), CXCL12(2), CXCR4(1), CYBB(8), EZR(4), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), ITK(5), JAM2(7), JAM3(2), MAPK13(2), MAPK14(4), MLLT4(17), MMP2(6), MMP9(11), MSN(12), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(4), NCF4(5), NOX1(10), NOX3(2), OCLN(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAC1(1), RAC2(2), RAP1A(3), RAP1B(2), RAPGEF3(7), RAPGEF4(9), RASSF5(2), RHOA(3), RHOH(1), ROCK1(15), ROCK2(10), SIPA1(1), THY1(1), TXK(6), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCAM1(9), VCL(8)	43336512	873	212	718	219	224	278	139	58	131	43	5.11e-15	3.57e-14
89	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(36), AXIN1(7), BTRC(11), CCND1(12), CREBBP(24), CSNK1A1(4), CSNK2A1(7), CTNNB1(63), FZD1(3), GSK3B(8), HDAC1(3), MAP3K7(8), MYC(6), NLK(5), PPARD(3), PPP2CA(4), TLE1(8), WIF1(4), WNT1(1)	9664312	217	113	169	32	51	90	24	20	26	6	5.22e-15	3.57e-14
90	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(26), AKT1(3), ATM(42), BAX(3), CDKN1A(1), CPB2(6), CSNK1A1(4), FHL2(1), HIF1A(12), IGFBP3(3), MAPK8(7), MDM2(3), NQO1(3), TP53(48)	7311288	162	84	145	39	44	39	26	9	38	6	5.22e-15	3.57e-14
91	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	44	IMPA1(3), IMPA2(5), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPP5B(4), INPPL1(14), IPMK(4), ITPK1(2), ITPKB(7), MINPP1(1), OCRL(15), PI4KA(9), PI4KB(6), PIK3C3(9), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PTEN(208), PTPMT1(1), SYNJ1(24), SYNJ2(8)	25313856	688	197	526	129	155	164	146	32	141	50	5.55e-15	3.76e-14
92	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(24), DAXX(6), PAX3(4), PML(6), RARA(1), RB1(23), SIRT1(4), SP100(10), TNFRSF1A(4), TNFRSF1B(1), TP53(48)	6675912	131	70	117	24	34	43	17	5	28	4	5.66e-15	3.79e-14
93	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(4), AKT3(7), BCL10(2), BLNK(3), BTK(4), CARD11(13), CD19(3), CD22(11), CD72(1), CD79B(2), CHUK(7), CR2(19), FCGR2B(3), FOS(2), GSK3B(8), IKBKB(8), INPP5D(9), JUN(1), KRAS(27), LILRB3(2), LYN(6), MALT1(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NRAS(8), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), RAC1(1), RAC2(2), RASGRP3(5), SYK(3), VAV1(10), VAV2(3), VAV3(9)	25554168	589	194	459	108	159	158	108	29	98	37	5.77e-15	3.82e-14
94	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	123	ACACA(27), ACACB(25), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), CALM2(3), CALML6(3), CBL(8), CBLB(11), CBLC(4), CRK(1), CRKL(4), ELK1(2), EXOC7(3), FBP1(2), FLOT2(1), FOXO1(9), G6PC(5), G6PC2(4), GCK(3), GRB2(3), GSK3B(8), GYS1(9), GYS2(14), IKBKB(8), INPP5D(9), INSR(12), IRS1(10), IRS4(16), KRAS(27), LIPE(7), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MKNK1(3), MKNK2(3), NRAS(8), PCK1(8), PCK2(7), PDE3A(14), PDE3B(9), PDPK1(2), PFKM(4), PFKP(6), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PKLR(5), PKM2(4), PPARGC1A(8), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R3A(17), PPP1R3B(2), PPP1R3C(3), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACA(4), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(4), PTPRF(19), PYGB(9), PYGL(6), PYGM(4), RAF1(5), RAPGEF1(9), RHEB(2), RHOQ(1), RPS6(6), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(5), SHC3(9), SHC4(5), SLC2A4(5), SOCS2(6), SOCS4(3), SORBS1(14), SOS1(10), SOS2(16), SREBF1(2), TRIP10(6), TSC1(9), TSC2(13)	52804904	997	207	851	221	257	324	174	39	158	45	5.88e-15	3.86e-14
95	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	135	APC(36), AXIN1(7), BTRC(11), CACYBP(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CCND1(12), CCND2(7), CCND3(3), CER1(2), CHD8(30), CREBBP(24), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK2A1(7), CSNK2A2(3), CTBP2(5), CTNNB1(63), CUL1(12), DAAM1(14), DAAM2(6), DKK1(3), DKK2(3), DKK4(3), DVL2(5), DVL3(7), EP300(23), FBXW11(4), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LEF1(8), LRP5(12), LRP6(16), MAP3K7(8), MAPK10(7), MAPK8(7), MAPK9(4), MYC(6), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NKD1(3), NLK(5), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PORCN(10), PPARD(3), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRICKLE1(5), PRICKLE2(2), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PSEN1(5), RAC1(1), RAC2(2), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RUVBL1(1), SENP2(6), SFRP1(5), SFRP2(2), SFRP4(9), SFRP5(2), SIAH1(3), SMAD2(7), SMAD3(5), SMAD4(3), TBL1X(5), TBL1XR1(11), TCF7(3), TCF7L1(2), TCF7L2(10), TP53(48), VANGL1(4), VANGL2(6), WIF1(4), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1)	54523544	847	191	763	226	220	341	103	63	110	10	6.44e-15	4.09e-14
96	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(5), ABL2(17), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), BTC(1), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CBL(8), CBLB(11), CBLC(4), CDKN1A(1), CDKN1B(6), CRK(1), CRKL(4), EGF(17), EGFR(10), ELK1(2), ERBB2(3), ERBB3(14), ERBB4(19), EREG(3), GAB1(5), GRB2(3), GSK3B(8), HBEGF(2), JUN(1), KRAS(27), MAP2K1(2), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MYC(6), NCK1(4), NCK2(7), NRAS(8), NRG1(20), NRG2(2), NRG3(11), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), RAF1(5), RPS6KB1(2), RPS6KB2(4), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SRC(2), STAT5A(2), STAT5B(3)	35542616	753	196	617	137	195	217	139	41	118	43	6.55e-15	4.09e-14
97	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), AMOTL1(10), ASH1L(32), CASK(13), CDC42(4), CDK4(3), CGN(9), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CSDA(2), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTTN(4), EPB41(9), EPB41L1(10), EPB41L2(11), EPB41L3(16), EXOC3(6), EXOC4(1), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), HCLS1(8), IGSF5(6), INADL(13), JAM2(7), JAM3(2), KRAS(27), LLGL1(9), LLGL2(4), MAGI1(20), MAGI2(23), MAGI3(12), MLLT4(17), MPDZ(16), MPP5(5), MRAS(1), MYH1(34), MYH10(23), MYH11(25), MYH13(17), MYH14(17), MYH15(19), MYH2(31), MYH3(20), MYH4(21), MYH6(12), MYH7(26), MYH7B(10), MYH8(25), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NRAS(8), OCLN(2), PARD3(19), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP2R3A(10), PPP2R4(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PTEN(208), RAB13(2), RAB3B(1), RHOA(3), RRAS(1), RRAS2(4), SPTAN1(23), SRC(2), SYMPK(15), TJAP1(5), TJP1(18), TJP2(13), TJP3(5), VAPA(5), YES1(6), ZAK(11)	68851992	1285	209	1108	326	298	424	210	76	219	58	6.66e-15	4.09e-14
98	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(7), ACTN2(7), ACTN3(6), CSK(1), CTNNA1(15), CTNNA2(9), CTNNB1(63), PTK2(8), PXN(4), SRC(2), VCL(8)	6883488	130	85	83	37	32	52	17	14	15	0	6.66e-15	4.09e-14
99	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT1(3), AKT2(4), AKT3(7), BCL2L1(3), CBL(8), CBLB(11), CBLC(4), CCND1(12), CCND2(7), CCND3(3), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(24), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), EP300(23), EPO(1), EPOR(3), GH1(2), GH2(2), GHR(8), GRB2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL13RA2(3), IL15(1), IL19(1), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL9R(1), IRF9(4), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), LIF(2), LIFR(19), MPL(4), MYC(6), OSM(1), OSMR(11), PIAS1(3), PIAS2(12), PIAS3(7), PIAS4(4), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIM1(3), PRL(4), PRLR(3), PTPN11(5), SOCS2(6), SOCS4(3), SOCS5(9), SOCS7(4), SOS1(10), SOS2(16), SPRED1(2), SPRED2(6), SPRY1(3), SPRY2(4), SPRY4(1), STAM(7), STAM2(4), STAT1(12), STAT2(5), STAT3(8), STAT4(6), STAT5A(2), STAT5B(3), STAT6(5), TPO(11), TSLP(1), TYK2(4)	51878128	947	209	828	220	236	293	160	59	154	45	6.77e-15	4.09e-14
100	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), ATF2(6), CDC42(4), DLD(3), DUSP10(5), GAB1(5), GCK(3), IL1R1(4), JUN(1), MAP2K4(4), MAP2K5(2), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK10(7), MAPK7(11), MAPK8(7), MAPK9(4), MYEF2(5), NFATC3(9), NR2C2(5), PAPPA(26), SHC1(5), TP53(48), TRAF6(3), ZAK(11)	17694552	293	101	278	76	91	102	32	15	49	4	6.77e-15	4.09e-14
101	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(5), ATM(42), ATR(26), CCNA1(3), CCND1(12), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(6), CDKN2A(1), DHFR(3), E2F1(6), GSK3B(8), HDAC1(3), RB1(23), SKP2(4), TGFB1(2), TGFB2(5), TGFB3(8), TP53(48)	10891416	221	96	204	46	43	78	29	11	50	10	6.77e-15	4.09e-14
102	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(8), APC(36), AXIN1(7), BTRC(11), CTNNB1(63), DLL1(6), FZD1(3), GSK3B(8), PSEN1(5), WNT1(1)	5656384	148	91	103	26	30	69	15	17	13	4	6.77e-15	4.09e-14
103	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), EGFR(10), IGF1R(10), MYC(6), POLR2A(17), PPP2CA(4), PRKCA(7), RB1(23), TEP1(9), TERF1(1), TERT(3), TNKS(13), TP53(48), XRCC5(5)	10034080	159	78	145	47	40	56	17	10	32	4	7.11e-15	4.25e-14
104	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(3), ARF3(2), CCND1(12), CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(6), CDKN2A(1), CFL1(1), E2F1(6), E2F2(2), MDM2(3), PRB1(2), TP53(48)	2864152	92	71	79	17	21	28	11	9	23	0	7.33e-15	4.34e-14
105	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(5), ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), ATM(42), ATR(26), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDC14A(4), CDC14B(5), CDC16(1), CDC20(4), CDC23(3), CDC25A(7), CDC25B(2), CDC25C(5), CDC27(13), CDC6(1), CDC7(10), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), CHEK1(2), CHEK2(11), CREBBP(24), CUL1(12), DBF4(11), E2F1(6), E2F2(2), E2F3(3), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), PCNA(2), PLK1(3), PRKDC(40), PTTG1(2), RB1(23), RBL1(13), RBL2(15), RBX1(1), SKP2(4), SMAD2(7), SMAD3(5), SMAD4(3), SMC1A(13), SMC1B(15), TGFB1(2), TGFB2(5), TGFB3(8), TP53(48), WEE1(1), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	49061344	651	139	621	154	143	261	87	36	107	17	7.44e-15	4.36e-14
106	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(3), ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ACVR1B(5), ACVR1C(3), CDC42(4), CDH1(12), CREBBP(24), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTNND1(17), EGFR(10), EP300(23), ERBB2(3), FARP2(13), FER(10), FGFR1(7), FYN(6), IGF1R(10), INSR(12), IQGAP1(9), LEF1(8), LMO7(17), MAP3K7(8), MAPK1(2), MAPK3(3), MET(9), MLLT4(17), NLK(5), PARD3(19), PTPN1(4), PTPRB(19), PTPRF(19), PTPRJ(10), PTPRM(14), PVRL1(6), PVRL2(3), PVRL3(5), PVRL4(4), RAC1(1), RAC2(2), RHOA(3), SMAD2(7), SMAD3(5), SMAD4(3), SNAI1(2), SNAI2(5), SORBS1(14), SRC(2), SSX2IP(8), TCF7(3), TCF7L1(2), TCF7L2(10), TGFBR1(3), TGFBR2(6), TJP1(18), VCL(8), WAS(8), WASF1(3), WASF2(3), WASF3(7), WASL(7), YES1(6)	43034944	614	141	554	166	151	241	85	45	92	0	7.88e-15	4.58e-14
107	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(42), ATR(26), BRCA1(14), BRCA2(42), CHEK1(2), CHEK2(11), FANCC(6), FANCD2(8), FANCE(8), FANCG(7), HUS1(3), MRE11A(9), RAD1(3), RAD17(7), RAD50(15), RAD51(2), RAD9A(2), TP53(48)	16318648	255	90	238	38	62	86	38	15	46	8	8.22e-15	4.69e-14
108	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), RB1(23), TP53(48), WEE1(1), YWHAH(2)	6469824	137	76	121	17	33	36	23	4	33	8	8.22e-15	4.69e-14
109	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CYCS(2), PRKCA(7), PTK2(8), PXN(4), STAT1(12), TLN1(20), TP53(48)	10061360	179	85	164	36	49	51	28	10	37	4	8.99e-15	5.08e-14
110	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(36), AXIN1(7), CCND1(12), CCND2(7), CCND3(3), CSNK1E(3), CTNNB1(63), DVL2(5), DVL3(7), FBXW2(3), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LDLR(6), MAPK10(7), MAPK9(4), MYC(6), PAFAH1B1(1), PLAU(4), PPP2R5C(4), PPP2R5E(5), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1)	19625728	335	122	282	110	88	134	42	32	33	6	9.21e-15	5.16e-14
111	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), ARHGAP5(18), BAD(2), BIRC2(10), BIRC3(2), BRAF(9), CAPN2(5), CAV2(1), CCND1(12), CCND2(7), CCND3(3), CDC42(4), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), CRK(1), CRKL(4), CTNNB1(63), DIAPH1(10), DOCK1(17), EGF(17), EGFR(10), ELK1(2), ERBB2(3), FARP2(13), FIGF(5), FLNA(27), FLNB(28), FLNC(27), FLT1(15), FN1(31), FYN(6), GRB2(3), GSK3B(8), HGF(13), IBSP(5), IGF1(2), IGF1R(10), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), JUN(1), KDR(20), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MET(9), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARVA(3), PARVB(1), PARVG(2), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PDPK1(2), PGF(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PRKCA(7), PRKCG(6), PTEN(208), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF1(9), RELN(36), RHOA(3), ROCK1(15), ROCK2(10), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SPP1(2), SRC(2), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TLN1(20), TLN2(20), TNC(14), TNN(11), TNR(11), TNXB(16), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCL(8), VEGFB(2), VEGFC(6), VWF(19), ZYX(11)	128844184	2120	227	1869	542	477	724	329	116	353	121	9.99e-15	5.55e-14
112	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(3), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPPL1(14), ITPKB(7), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CA(142), PIK3CB(13), PIK3CG(18), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23)	16225152	354	148	267	75	105	109	71	22	45	2	1.12e-14	6.17e-14
113	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CD22(11), CR2(19), CSK(1), DAG1(4), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), INPP5D(9), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), MAP4K1(9), MAPK1(2), MAPK3(3), NFATC2(9), NR0B2(2), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLCG2(23), PPP1R13B(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), PTPRC(11), RAF1(5), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10)	26176400	546	189	436	109	140	153	103	25	84	41	1.47e-14	7.99e-14
114	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(2), CUL1(12), E2F1(6), FBXW7(32), RB1(23)	2958392	75	44	67	8	15	29	10	3	12	6	4.17e-14	2.26e-13
115	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(42), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDAN1(8), CDC14A(4), CDC14B(5), CDC20(4), CDC25A(7), CDC25B(2), CDC25C(5), CDC6(1), CDC7(10), CDH1(12), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), DTX4(4), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), HDAC8(2), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MPEG1(7), MPL(4), PCNA(2), PLK1(3), PRKDC(40), PTPRA(7), PTTG1(2), RB1(23), RBL1(13), SKP2(4), SMAD4(3), TBC1D8(9), TGFB1(2), TP53(48), WEE1(1)	40479800	514	121	487	137	116	208	72	21	83	14	6.73e-14	3.60e-13
116	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	54	BAK1(3), BAX(3), BFAR(6), BTK(4), CAD(21), CASP10(8), CASP3(3), CASP8(12), CASP8AP2(3), CDK2AP1(1), CSNK1A1(4), DAXX(6), DEDD(1), DEDD2(2), DIABLO(2), EGFR(10), EPHB2(8), FAF1(6), FAIM2(2), IL8(3), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MET(9), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(1), PTPN13(20), RALBP1(4), RIPK1(8), ROCK1(15), SMPD1(10), TP53(48), TPX2(10), TRAF2(2), TUFM(4)	25073792	348	105	326	86	80	137	39	16	70	6	1.16e-13	6.16e-13
117	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	220	ADCYAP1R1(5), ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRA2B(6), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), C5AR1(3), CALCR(4), CALCRL(7), CCKAR(9), CCKBR(3), CGA(1), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CNR1(6), CNR2(3), CRHR1(2), CRHR2(1), CTSG(3), CYSLTR1(6), CYSLTR2(3), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2(8), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GABBR1(8), GABBR2(13), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GABRB1(7), GABRB2(12), GABRB3(9), GABRE(5), GABRG1(6), GABRG2(14), GABRG3(7), GABRP(3), GABRQ(5), GABRR1(3), GALR1(2), GALR3(2), GH1(2), GH2(2), GHR(8), GHRHR(1), GHSR(7), GIPR(3), GLP1R(5), GLP2R(8), GLRA1(6), GLRA2(6), GLRA3(8), GLRB(6), GNRHR(3), GPR156(4), GPR50(4), GPR63(4), GPR83(2), GRIA1(11), GRIA2(17), GRIA3(18), GRIA4(15), GRID1(7), GRID2(9), GRIK1(10), GRIK2(10), GRIK3(13), GRIK4(3), GRIK5(15), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRIN3A(12), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM6(9), GRM7(10), GRM8(17), GRPR(3), GZMA(6), HCRTR2(6), HRH1(9), HRH2(3), HRH4(4), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LEP(1), LEPR(10), LHB(2), LHCGR(14), LTB4R(2), LTB4R2(3), MAS1(1), MC2R(1), MC3R(5), MC4R(3), MC5R(8), MCHR1(7), MCHR2(1), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPFFR1(2), NPFFR2(9), NPY1R(3), NPY2R(3), NPY5R(7), NR3C1(11), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(2), P2RY10(5), P2RY11(8), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(5), P2RY6(3), PARD3(19), PPYR1(6), PRL(4), PRLHR(1), PRLR(3), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(6), PTGER2(2), PTGER3(7), PTGER4(7), PTGFR(9), PTGIR(2), PTH2R(8), RXFP1(15), RXFP2(11), SCTR(3), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(6), TACR1(5), TACR2(2), TACR3(8), THRA(4), THRB(2), TRHR(2), TRPV1(3), TSHB(3), TSHR(7), VIPR1(2)	75986456	1253	151	1211	448	376	522	188	52	113	2	6.69e-10	3.52e-09
118	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), BTRC(11), CDC16(1), CDC20(4), CDC23(3), CDC27(13), CUL1(12), CUL2(8), CUL3(13), FBXW11(4), FBXW7(32), ITCH(7), RBX1(1), SKP2(4), SMURF1(9), SMURF2(5), TCEB1(2), UBA1(14), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2E2(2), UBE2E3(6), VHL(2), WWP1(12), WWP2(4)	14513704	215	78	205	45	45	89	29	18	32	2	2.87e-08	1.50e-07
119	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	163	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY7(5), ADCY8(15), ADCY9(17), ADORA2A(4), ADORA2B(1), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), ATP2A1(9), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), ATP2B4(13), AVPR1A(7), AVPR1B(2), BDKRB1(2), BDKRB2(7), BST1(1), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CCKAR(9), CCKBR(3), CD38(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM5(8), CHRNA7(4), CYSLTR1(6), CYSLTR2(3), DRD1(5), EDNRA(5), EGFR(10), ERBB2(3), ERBB3(14), ERBB4(19), F2R(6), GNA11(2), GNA14(5), GNA15(1), GNAL(6), GNAS(16), GRIN1(3), GRIN2A(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), GRPR(3), HRH1(9), HRH2(3), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), LHCGR(14), LTB4R2(3), MYLK(10), MYLK2(6), NOS1(14), NOS3(6), NTSR1(4), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(10), PDE1B(6), PDE1C(10), PDGFRA(19), PDGFRB(10), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PLN(1), PPID(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(9), PTK2B(13), RYR1(59), RYR2(89), RYR3(65), SLC25A4(2), SLC25A5(1), SLC25A6(4), SLC8A1(9), SLC8A2(3), SLC8A3(9), SPHK1(2), SPHK2(1), TACR1(5), TACR2(2), TACR3(8), TNNC1(2), TNNC2(3), TRHR(2), TRPC1(12), VDAC1(2), VDAC2(1), VDAC3(2)	95398904	1385	151	1348	515	397	563	192	69	149	15	4.30e-08	2.22e-07
120	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(9), CPEB1(7), EGFR(10), ERBB2(3), ERBB4(19), ETS1(4), ETS2(5), ETV6(5), ETV7(3), FMN2(18), GRB2(3), KRAS(27), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH2(9), NOTCH3(20), NOTCH4(10), PIWIL1(13), PIWIL2(13), PIWIL3(7), PIWIL4(9), RAF1(5), SOS1(10), SOS2(16), SPIRE1(6)	16813656	238	85	207	41	66	88	45	12	25	2	7.70e-08	3.95e-07
121	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(8), BRAF(9), CACNA1A(15), CRHR1(2), GNA11(2), GNA12(7), GNA13(7), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GNAZ(4), GRIA1(11), GRIA2(17), GRIA3(18), GRID2(9), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), IGF1(2), IGF1R(10), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), LYN(6), MAP2K1(2), MAPK1(2), MAPK3(3), NOS1(14), NOS3(6), NPR1(10), NPR2(10), NRAS(8), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), RAF1(5), RYR1(59)	39391328	616	123	566	192	168	251	102	28	63	4	1.02e-07	5.19e-07
122	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), ANXA6(8), ARRB1(4), ARRB2(3), ATP1A4(19), ATP1B1(3), ATP1B2(4), ATP1B3(2), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1S(22), CACNB1(7), CACNB3(4), CALM2(3), CALR(1), CAMK1(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CASQ1(4), CASQ2(6), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), GJA1(5), GJA4(1), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GNA11(2), GNAI2(4), GNAI3(3), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GRK4(9), GRK5(8), GRK6(2), ITPR1(23), ITPR2(25), ITPR3(15), KCNB1(11), KCNJ3(9), KCNJ5(5), MIB1(6), MYCBP(1), NME7(2), PEA15(2), PLCB3(9), PLN(1), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR2(89), RYR3(65), SLC8A1(9), SLC8A3(9), USP5(11), YWHAH(2), YWHAQ(1)	68189584	958	136	933	349	268	398	116	48	117	11	4.02e-07	2.03e-06
123	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(3), CCNB1(7), CCND1(12), CCND2(7), CCND3(3), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), E2F1(6), RB1(23), RBL1(13)	5580744	107	46	103	19	18	40	15	7	23	4	7.88e-07	3.94e-06
124	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1(9), ACVR1B(5), ACVR1C(3), ACVR2A(5), ACVR2B(5), ACVRL1(1), AMHR2(2), BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BMPR1A(4), BMPR1B(6), BMPR2(9), CHRD(8), COMP(3), CREBBP(24), CUL1(12), DCN(7), E2F4(2), EP300(23), FST(4), GDF5(7), GDF6(3), ID1(2), ID2(1), IFNG(5), INHBA(3), INHBB(2), INHBC(1), INHBE(4), LEFTY1(3), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(3), MYC(6), NODAL(2), NOG(2), PITX2(9), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), RBL1(13), RBL2(15), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(7), SMAD3(5), SMAD4(3), SMAD5(8), SMAD7(2), SMAD9(1), SMURF1(9), SMURF2(5), SP1(6), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), THBS1(9), THBS2(17), THBS3(2), THBS4(6), ZFYVE16(18), ZFYVE9(15)	34539456	506	108	479	135	140	194	65	33	67	7	2.02e-06	0.000010
125	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(14), CARM1(4), CCND1(12), CREBBP(24), EP300(23), ERCC3(8), ESR1(10), GRIP1(11), GTF2A1(3), GTF2E1(3), GTF2F1(5), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), MEF2C(8), NCOR2(16), NR0B1(6), NRIP1(14), PELP1(9), POLR2A(17), SRA1(1), TBP(3)	15693192	240	75	229	75	39	114	32	12	41	2	5.53e-06	0.000027
126	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ATF4(3), CACNA1C(21), CACNA1D(23), CACNA1F(30), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDC42(4), CGA(1), EGFR(10), ELK1(2), GNA11(2), GNAS(16), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(3), HBEGF(2), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), KRAS(27), LHB(2), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK9(4), MMP14(3), MMP2(6), NRAS(8), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLD1(9), PLD2(7), PRKACA(4), PRKACG(7), PRKCA(7), PRKCD(4), PRKX(2), PTK2B(13), RAF1(5), SOS1(10), SOS2(16), SRC(2)	45180888	630	120	592	195	183	247	87	29	72	12	9.74e-06	0.000048
127	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	ADAM17(8), CREBBP(24), CTBP2(5), DLL1(6), DLL3(5), DLL4(2), DTX1(5), DTX2(2), DTX3(4), DTX3L(4), DTX4(4), DVL2(5), DVL3(7), EP300(23), HDAC1(3), HDAC2(4), HES1(1), JAG1(13), MAML1(6), MAML2(5), MAML3(14), MFNG(3), NCOR2(16), NCSTN(7), NOTCH2(9), NOTCH3(20), NOTCH4(10), NUMB(7), NUMBL(3), PSEN1(5), PSEN2(3), RBPJ(4), RBPJL(7), SNW1(5)	20548784	249	80	243	77	59	106	26	12	42	4	0.000014	0.000069
128	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	ACTG1(1), APAF1(11), ARHGDIB(1), BAG4(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CRADD(2), CYCS(2), DAXX(6), DFFB(3), GSN(4), LMNA(5), LMNB1(4), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK8(7), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(17), PAK2(3), PRKCD(4), PRKDC(40), PSEN1(5), PSEN2(3), PTK2(8), RASA1(23), RB1(23), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2)	24767264	335	83	326	92	85	117	46	19	62	6	0.000023	0.00011
129	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(5), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(19), CDC42(4), CDK5(1), CFL1(1), CFL2(7), CXCL12(2), CXCR4(1), DCC(24), DPYSL2(9), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(1), EFNB1(4), EFNB3(1), EPHA1(8), EPHA2(3), EPHA3(11), EPHA4(14), EPHA5(20), EPHA6(17), EPHA7(8), EPHA8(9), EPHB1(19), EPHB2(8), EPHB3(2), EPHB4(3), EPHB6(7), FES(14), FYN(6), GNAI1(4), GNAI2(4), GNAI3(3), GSK3B(8), ITGB1(5), KRAS(27), L1CAM(13), LIMK1(6), LIMK2(10), LRRC4C(9), MAPK1(2), MAPK3(3), MET(9), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NGEF(10), NRAS(8), NRP1(11), NTN1(3), NTN4(4), NTNG1(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLXNA1(20), PLXNA2(21), PLXNA3(14), PLXNB1(10), PLXNC1(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PTK2(8), RAC1(1), RAC2(2), RASA1(23), RGS3(8), RHOA(3), RND1(5), ROBO1(17), ROBO2(15), ROBO3(9), ROCK1(15), ROCK2(10), SEMA3A(6), SEMA3B(4), SEMA3C(9), SEMA3D(8), SEMA3E(5), SEMA3F(5), SEMA3G(3), SEMA4A(4), SEMA4B(3), SEMA4C(7), SEMA4D(6), SEMA4F(10), SEMA4G(3), SEMA5A(15), SEMA5B(6), SEMA6A(7), SEMA6C(2), SEMA6D(16), SEMA7A(9), SLIT1(10), SLIT2(22), SLIT3(18), SRGAP1(15), SRGAP2(9), SRGAP3(7), UNC5A(8), UNC5B(5), UNC5C(7), UNC5D(11)	66634624	926	130	873	295	260	343	144	41	132	6	0.000068	0.00033
130	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(2), CCND1(12), CCNE2(5), CDK2(2), CDK4(3), CDKN1B(6), CDKN2A(1), E2F1(6), E2F2(2), E2F4(2), PRB1(2)	2975504	46	32	45	10	5	15	10	5	11	0	0.00010	0.00048
131	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(3), CSF1R(6), DDX20(4), E2F1(6), E2F4(2), ETS1(4), ETS2(5), ETV3(10), FOS(2), HDAC2(4), HDAC5(10), JUN(1), NCOR2(16), RBL1(13), RBL2(15), SIN3A(24), SIN3B(11)	8338256	136	54	129	28	27	51	18	13	24	3	0.00010	0.00048
132	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(24), EP300(23), ESR1(10), MAPK1(2), MAPK3(3), PELP1(9), SRC(2)	5108800	73	41	70	18	12	28	12	5	16	0	0.00012	0.00056
133	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(2), CDKN1B(6), CUL1(12), E2F1(6), RB1(23), RBX1(1), SKP2(4)	3109920	54	30	53	8	8	21	10	2	9	4	0.00015	0.00069
134	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(4), CTSD(3), ESR1(10), GREB1(14), HSPB2(1), MTA1(4), MTA3(4), PDZK1(3), TUBA8(7)	3541440	50	33	49	13	11	22	6	6	5	0	0.00059	0.0027
135	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	148	ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CCRL1(4), CHML(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CMKLR1(8), CNR1(6), CNR2(3), CX3CR1(4), CXCR3(5), CXCR4(1), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GPR17(3), GPR174(9), GPR3(5), GPR37(7), GPR37L1(4), GPR4(8), GPR50(4), GPR6(4), GPR63(4), GPR77(1), GPR83(2), GPR85(4), GPR87(5), GRPR(3), HCRTR2(6), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LHCGR(14), LTB4R(2), MAS1(1), MC3R(5), MC4R(3), MC5R(8), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPN1SW(6), OPN3(1), OPRK1(6), OPRM1(8), OR10A5(3), OR12D3(6), OR1F1(3), OR1Q1(3), OR2H1(1), OR5V1(7), OR7A5(4), OR7C1(6), OR8B8(3), OXTR(4), P2RY1(2), P2RY10(5), P2RY11(8), P2RY12(2), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(3), PPYR1(6), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), RGR(5), RHO(3), RRH(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), SUCNR1(1), TRHR(2)	40485752	652	107	634	230	191	291	87	29	54	0	0.00063	0.0029
136	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(6), CDC42(4), CREB1(5), DAXX(6), DDIT3(1), ELK1(2), GRB2(3), HMGN1(1), HSPB2(1), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MYC(6), PLA2G4A(9), RAC1(1), RIPK1(8), RPS6KA5(7), SHC1(5), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2)	13175992	197	66	193	50	45	91	20	12	27	2	0.00072	0.0033
137	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), AKAP1(7), AKAP10(7), AKAP11(22), AKAP12(14), AKAP3(13), AKAP5(1), AKAP6(26), AKAP7(4), AKAP8(3), AKAP9(43), ARHGEF1(9), CALM2(3), CHMP1B(1), GNA11(2), GNA12(7), GNA13(7), GNA14(5), GNA15(1), GNAI2(4), GNAI3(3), GNAL(6), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB5(1), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNGT2(2), ITPR1(23), KCNJ3(9), KRAS(27), NRAS(8), PALM2(5), PDE1A(10), PDE1B(6), PDE1C(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE7B(5), PDE8A(5), PDE8B(15), PLCB3(9), PPP3CA(2), PPP3CC(4), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(6), USP5(11)	41725752	583	108	546	198	166	206	99	33	72	7	0.00088	0.0040
138	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	9	CREB1(5), FOS(2), JUN(1), KEAP1(7), MAPK1(2), MAPK14(4), MAPK8(7), NFE2L2(12), PRKCA(7)	3004024	47	31	44	8	6	15	10	7	9	0	0.00091	0.0041
139	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(36), CDH1(12), CREBBP(24), EP300(23), MAP2K1(2), MAP3K7(8), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6)	9292808	139	56	135	37	26	59	19	8	23	4	0.0010	0.0045
140	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(4), CASP2(4), CHUK(7), CRADD(2), IKBKB(8), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP4K2(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFRSF1A(4), TRAF2(2)	8353136	119	47	118	29	19	46	17	14	21	2	0.0012	0.0052
141	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(3), CDK2(2), CUL1(12), E2F1(6), RB1(23), SKP2(4)	3030312	50	28	49	8	8	18	10	2	8	4	0.0013	0.0058
142	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), PRKCE(7), SOD1(2)	2907552	63	33	58	21	19	22	8	4	10	0	0.0017	0.0076
143	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(5), CADM1(2), CADM3(5), CD2(4), CD22(11), CD226(5), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(2), CD40LG(5), CD58(1), CD6(5), CD80(5), CD86(4), CD8A(2), CD8B(1), CD99(1), CDH1(12), CDH2(11), CDH3(5), CDH4(13), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(12), CNTN2(6), CNTNAP1(9), CNTNAP2(24), CTLA4(2), F11R(1), GLG1(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(1), ICAM2(3), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(8), ITGA6(10), ITGA8(14), ITGA9(13), ITGAL(12), ITGAM(19), ITGAV(6), ITGB1(5), ITGB2(10), ITGB7(4), ITGB8(4), JAM2(7), JAM3(2), L1CAM(13), MAG(7), MPZ(1), MPZL1(2), NCAM1(7), NCAM2(30), NEGR1(3), NEO1(12), NFASC(27), NLGN1(6), NLGN2(4), NLGN3(18), NRCAM(10), NRXN1(25), NRXN2(16), NRXN3(21), OCLN(2), PTPRC(11), PTPRF(19), PTPRM(14), PVR(2), PVRL1(6), PVRL2(3), PVRL3(5), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SELE(5), SELL(3), SELP(10), SELPLG(7), SIGLEC1(10), SPN(1), VCAM1(9), VCAN(45)	51960712	721	118	696	228	194	298	101	35	85	8	0.0021	0.0092
144	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(3), ACTA2(5), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADM(2), ARRB1(4), ARRB2(3), ATF1(4), ATF2(6), ATF3(3), ATF4(3), ATF5(5), ATP2A2(6), ATP2A3(9), CACNB3(4), CALCA(1), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CNN1(2), CORIN(8), CRHR1(2), DGKZ(8), ETS2(5), FOS(2), GABPA(3), GABPB2(8), GBA2(9), GJA1(5), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GRK4(9), GRK5(8), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(9), IGFBP1(4), IGFBP2(4), IGFBP3(3), IGFBP6(1), IL1B(2), IL6(4), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), MIB1(6), MYL2(1), MYLK2(6), NFKB1(7), NOS1(14), NOS3(6), OXTR(4), PDE4B(12), PDE4D(7), PLCB3(9), PLCD1(5), PLCG1(8), PLCG2(23), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RAMP1(1), RAMP3(2), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR2(89), RYR3(65), SLC8A1(9), SP1(6), TNXB(16), USP5(11), YWHAH(2), YWHAQ(1)	62451856	844	120	819	316	244	352	112	37	90	9	0.0026	0.011
145	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(1), BAG4(3), CASP2(4), CASP3(3), CASP8(12), CRADD(2), DFFB(3), JUN(1), LMNA(5), LMNB1(4), MADD(15), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), RB1(23), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TRAF2(2)	14067304	200	59	195	61	50	65	28	11	40	6	0.0027	0.012
146	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CALM2(3), CRKL(4), GRB2(3), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), PAK1(1), PLCG1(8), PRKCA(7), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4)	9544280	120	54	116	39	32	42	15	13	16	2	0.0029	0.012
147	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5521472	83	40	81	21	15	38	7	4	19	0	0.0046	0.019
148	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5521472	83	40	81	21	15	38	7	4	19	0	0.0046	0.019
149	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5521472	83	40	81	21	15	38	7	4	19	0	0.0046	0.019
150	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(1), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(1), IL6(4), IL8(3), KITLG(2)	2280856	29	24	29	7	4	13	4	0	8	0	0.0046	0.019
151	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(12), ADCY8(15), ARAF(8), ATF4(3), BRAF(9), CACNA1C(21), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CREBBP(24), EP300(23), GRIA1(11), GRIA2(17), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), MAP2K1(2), MAPK1(2), MAPK3(3), NRAS(8), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R1A(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF3(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12)	36093920	510	103	475	168	128	197	101	18	64	2	0.0051	0.021
152	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(3), BDKRB2(7), CALM2(3), CHRM1(3), CHRNA1(6), FLT1(15), FLT4(9), KDR(20), NOS3(6), PDE2A(11), PDE3A(14), PDE3B(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKG1(4), PRKG2(8), RYR2(89), SLC7A1(6), SYT1(4), TNNI1(1)	13895688	242	62	236	83	58	103	30	11	35	5	0.0057	0.023
153	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1)	4000984	53	33	53	18	11	25	6	1	10	0	0.0063	0.025
154	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6)	941904	14	14	14	5	1	7	1	0	5	0	0.0064	0.026
155	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(7), IFNB1(2), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL6(4), IRAK1(4), IRAK2(5), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(5), TGFB3(8), TRAF6(3)	10439560	141	52	138	32	29	54	22	11	23	2	0.0067	0.027
156	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(6), CD8A(2), CSF1(3), CSF3(1), EPO(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3)	2205464	24	22	24	10	8	9	3	0	4	0	0.0072	0.029
157	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	55	ATP12A(13), ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ATP7B(9), COX10(1), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2), PPA2(3), SDHA(10), SDHB(1), SHMT1(4), UQCRB(3), UQCRC1(2)	12514576	178	63	174	45	47	76	19	8	28	0	0.0077	0.030
158	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(8), CD28(3), CD3D(3), CSK(1), CTLA4(2), DAG1(4), EPHB2(8), FBXW7(32), GRB2(3), ITK(5), ITPKB(7), LCK(3), LCP2(4), MAPK1(2), NCK1(4), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLCG1(8), PTPRC(11), RAF1(5), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), SOS1(10), SOS2(16), VAV1(10), ZAP70(6)	19522808	233	69	221	80	68	85	30	10	36	4	0.0090	0.035
159	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), FDXR(2), SHMT1(4)	5818576	85	40	83	21	15	38	9	4	19	0	0.0091	0.035
160	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(3), ALG6(3), CCKBR(3), CCR2(4), CCR3(4), CELSR2(18), CELSR3(18), CHRM2(8), CHRM3(6), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(3), EMR3(3), F2R(6), FSHR(14), GHRHR(1), GNRHR(3), GPR116(15), GPR132(6), GPR133(11), GPR143(4), GPR17(3), GPR18(1), GPR55(2), GPR56(2), GPR61(2), GPR77(1), GPR84(3), GRM1(18), GRPR(3), HRH4(4), LGR6(13), LPHN2(19), LPHN3(14), LTB4R2(3), NTSR1(4), OR8G2(5), P2RY11(8), P2RY13(1), PTGFR(9), SMO(5), SSTR2(2), TAAR5(5), TSHR(7), VN1R1(4)	21046272	283	74	280	98	85	113	37	16	32	0	0.0099	0.038
161	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(4), CALM2(3), CD79B(2), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK14(4), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10)	13570808	155	61	150	48	51	43	23	14	22	2	0.0099	0.038
162	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADK(1), ADSL(5), ADSS(6), AK2(2), AK5(5), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), ATP1B1(3), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), FHIT(2), GART(6), GDA(3), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NPR1(10), NPR2(10), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), PAICS(3), PAPSS1(5), PAPSS2(5), PDE1A(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6B(5), PDE6C(10), PDE7B(5), PDE8A(5), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), PPAT(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5)	44584696	564	100	555	172	144	236	75	33	76	0	0.010	0.038
163	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(13), AR(4), ESR1(10), ESR2(4), ESRRA(2), HNF4A(5), NPM1(2), NR0B1(6), NR1D1(3), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(2), NR1I3(5), NR2C2(5), NR2E1(5), NR2F1(5), NR2F2(5), NR3C1(11), NR4A1(4), NR4A2(6), NR5A2(10), PGR(10), PPARD(3), PPARG(5), RARA(1), RARB(4), RARG(2), ROR1(4), RORA(8), RORC(8), RXRA(1), RXRG(6), THRA(4), THRB(2), VDR(7)	14590088	179	62	171	55	51	75	27	11	15	0	0.010	0.039
164	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(7), CREBBP(24), DUSP1(2), EP300(23), IKBKB(8), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(6), MAP3K14(4), MAP3K7(8), MAPK14(4), MYD88(1), NFKB1(7), NFKBIA(2), NR3C1(11), RELA(4), TGFBR1(3), TGFBR2(6), TLR2(11)	10374088	143	52	140	45	28	54	26	9	26	0	0.011	0.043
165	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(10), ESR2(4), PDE1A(10), PDE1B(6), PLCB1(4), PLCB2(7), PRL(4), VIP(1)	3849952	46	32	45	20	12	16	9	4	5	0	0.011	0.043
166	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	FAU(1), MRPS7(3), RPL10A(1), RPL10L(7), RPL11(1), RPL14(7), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22L1(3), RPL23A(4), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL6(2), RPL8(1), RPL9(1), RPS10(1), RPS12(2), RPS13(1), RPS15A(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS29(2), RPS3(2), RPS3A(1), RPS6(6), RPS7(3), RPS8(2), RPS9(1)	7791416	98	45	89	29	17	46	18	3	14	0	0.012	0.043
167	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(7), AGTR1(1), ATF2(6), CALM2(3), EGFR(10), ELK1(2), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PAK1(1), PRKCA(7), PTK2(8), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4)	11993776	148	58	144	45	36	55	18	13	24	2	0.012	0.044
168	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(6), NFYB(2), NFYC(1), RB1(23), SP1(6), SP3(8)	2476032	46	24	44	9	7	16	10	1	8	4	0.012	0.045
169	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(1), AGTR2(7), ATP8A1(13), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CX3CR1(4), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GNRHR(3), GPR77(1), GRPR(3), LHCGR(14), MC2R(1), MC3R(5), MC4R(3), MC5R(8), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), PPYR1(6), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), TACR1(5), TACR2(2), TACR3(8), TRHR(2), TSHR(7)	17648176	281	70	276	103	71	135	29	11	35	0	0.012	0.045
170	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(4), AKT3(7), ASAH1(6), BRAF(9), DAG1(4), DRD2(6), EGFR(10), EPHB2(8), GRB2(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(13), PITX2(9), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), RAF1(5), RGS20(1), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT3(8), TERF2IP(2)	21195568	259	73	250	97	61	106	41	13	34	4	0.013	0.046
171	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(2), CDC40(7), CLK2(7), CLK3(4), CLK4(5), COL2A1(10), CPSF1(7), CPSF2(10), CPSF3(6), CPSF4(1), CSTF1(3), CSTF2(10), CSTF2T(4), CSTF3(9), DDIT3(1), DDX1(3), DDX20(4), DHX15(6), DHX16(9), DHX38(6), DHX8(6), DHX9(11), DICER1(27), DNAJC8(1), FUS(2), GIPC1(1), METTL3(5), NCBP1(8), NCBP2(2), NONO(11), NXF1(3), PABPN1(1), PAPOLA(9), PHF5A(1), POLR2A(17), PPM1G(6), PRPF18(4), PRPF3(8), PRPF4(4), PRPF4B(15), PRPF8(17), PSKH1(6), PTBP1(1), PTBP2(6), RBM17(4), RBM5(4), RNGTT(8), RNMT(6), SF3A1(3), SF3A3(5), SF3B1(15), SF3B2(7), SF3B4(3), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(2), SNRPE(1), SNRPG(1), SPOP(19), SRPK1(10), SRPK2(5), SRRM1(8), SUPT5H(15), U2AF1(3), U2AF2(5), XRN2(13)	37685832	432	99	415	123	128	155	63	33	53	0	0.013	0.049
172	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(2), CHUK(7), ELK1(2), FOS(2), IKBKB(8), IRAK1(4), JUN(1), LY96(3), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TIRAP(2), TLR10(18), TLR2(11), TLR3(5), TLR4(13), TLR6(9), TLR7(12), TLR9(5), TRAF6(3)	12986768	185	59	183	42	44	63	31	16	27	4	0.014	0.051
173	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(24), EP300(23), LPL(9), NCOA1(15), NCOA2(13), PPARG(5), RXRA(1)	6593576	90	44	88	23	18	32	15	7	18	0	0.014	0.051
174	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(32), ASH2L(9), C17orf79(2), CARM1(4), CTCFL(11), DOT1L(5), EED(6), EHMT2(1), EZH1(8), EZH2(9), FBXO11(5), HCFC1(21), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(10), MEN1(5), MLL(25), MLL2(38), MLL3(44), MLL4(40), MLL5(20), NSD1(25), OGT(13), PPP1CA(3), PPP1CB(4), PPP1CC(2), PRDM2(14), PRDM9(23), PRMT1(2), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), RBBP5(7), SATB1(14), SETD1A(9), SETD2(26), SETD7(5), SETD8(3), SETDB1(14), SETDB2(11), SETMAR(5), SMYD3(4), STK38(7), SUV39H1(7), SUV39H2(2), SUV420H1(11), SUZ12(5), WHSC1(15), WHSC1L1(16)	42288712	570	100	556	144	130	221	88	25	98	8	0.015	0.052
175	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(2), C1GALT1C1(4), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GCNT1(3), GCNT3(3), OGT(13), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(2), WBSCR17(11)	11595240	161	58	154	60	37	59	27	12	26	0	0.015	0.052
176	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), DRD1(5), DRD2(6), DRD3(4), DRD5(8), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3)	8312960	162	51	155	51	56	64	25	8	9	0	0.015	0.053
177	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(2), BAX(3), CASP8(12), CYCS(2), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(7), NSMAF(7), RAF1(5), RELA(4), RIPK1(8), SMPD1(10), TNFRSF1A(4), TRAF2(2)	7292936	108	43	105	22	23	36	18	5	24	2	0.016	0.055
178	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(17), EGFR(10), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(19), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SPRY1(3), SPRY2(4), SPRY4(1), SRC(2)	9088704	117	51	113	28	23	44	25	6	19	0	0.017	0.060
179	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(6), CSF1(3), CSF3(1), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3), LTA(2), TGFB1(2), TGFB2(5), TGFB3(8)	4784416	55	36	54	20	13	28	8	1	5	0	0.017	0.060
180	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(5), CREBBP(24), EP300(23), NCOA3(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RARA(1), RXRA(1)	7226968	87	44	84	27	18	34	10	6	19	0	0.019	0.066
181	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), NAT1(7), NAT2(3), XDH(9)	2971784	44	30	41	15	17	19	4	1	3	0	0.019	0.066
182	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(3), AKT2(4), AKT3(7), ARHGEF11(18), CDC42(4), DLG4(10), GNA13(7), LPA(11), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK8(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PI3(2), PIK3CB(13), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RDX(11), ROCK1(15), ROCK2(10), SERPINA4(4), SRF(2)	17428200	240	66	232	66	53	97	28	15	41	6	0.021	0.072
183	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(6), ABAT(9), ADSL(5), ADSS(6), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), CAD(21), CRAT(2), DARS(4), DDO(6), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), PC(9)	8972888	125	51	123	42	31	52	18	6	18	0	0.022	0.074
184	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(36), ASAH1(6), DAG1(4), DLG4(10), EPHB2(8), GNAI1(4), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PITX2(9), PTX3(1), RAC1(1), RHO(3), RYR1(59)	16874416	228	70	220	93	64	99	28	7	24	6	0.025	0.084
185	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(3), BAD(2), CABIN1(11), CALM2(3), CAMK2B(1), CAMK4(3), CD3E(1), CD3G(1), CD69(1), CDKN1A(1), CNR1(6), CREBBP(24), CSNK2A1(7), CTLA4(2), EGR2(4), EGR3(5), EP300(23), FCER1A(7), FCGR3A(1), FKBP1B(1), FOS(2), FOSL1(3), GATA3(2), GATA4(1), GSK3A(8), GSK3B(8), ICOS(2), IFNB1(2), IFNG(5), IL10(2), IL1B(2), IL2(2), IL2RA(2), IL6(4), IL8(3), ITK(5), KPNA5(6), MAPK14(4), MAPK8(7), MAPK9(4), MEF2A(3), MEF2B(1), MEF2D(5), MYF5(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB2(9), NFKBIE(5), NPPB(2), NUP214(13), P2RX7(1), PAK1(1), PPIA(1), PPP3CB(5), PPP3CC(4), PTPRC(11), RELA(4), SLA(5), SP1(6), SP3(8), TGFB1(2), TRAF2(2), TRPV6(9), VAV1(10), VAV2(3), VAV3(9), XPO5(7)	31985056	353	85	344	121	88	142	51	18	54	0	0.025	0.084
186	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL6(4), IL6R(7), IL6ST(6), JAK1(16), JAK2(14), JAK3(5), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(5), RAF1(5), SHC1(5), SOS1(10), SRF(2), STAT3(8)	8542856	107	47	104	26	23	39	18	9	14	4	0.025	0.084
187	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(7), CREBBP(24), EP300(23), HDAC3(8), IKBKB(8), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3)	7868544	99	42	95	29	14	43	16	3	23	0	0.027	0.089
188	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADK(1), ADSL(5), ADSS(6), ADSSL1(5), AK2(2), AK5(5), AK7(10), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), FHIT(2), GART(6), GDA(3), GMPR(6), GMPR2(2), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NME7(2), NPR1(10), NPR2(10), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), NUDT5(1), PAICS(3), PAPSS1(5), PAPSS2(5), PDE10A(11), PDE11A(10), PDE1A(10), PDE1C(10), PDE2A(11), PDE3B(9), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6D(1), PDE7B(5), PDE8A(5), PDE8B(15), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), XDH(9)	57999016	736	108	718	224	189	292	105	45	105	0	0.030	0.098
189	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(17), EGFR(10), ERBB3(14), NRG1(20)	3732648	61	32	59	13	13	26	11	4	7	0	0.031	0.10
190	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(6), IL1B(2), IL5(1), IL5RA(7), IL6(4)	1997640	24	19	22	7	2	12	2	0	8	0	0.031	0.10
191	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	ADRBK1(4), AKT1(3), AKT2(4), AKT3(7), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PIK3CB(13), PITX2(9), PLD1(9), PLD2(7), PLD3(2), VN1R1(4)	15765608	175	61	171	65	40	76	20	9	28	2	0.035	0.11
192	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(6), BCR(4), BLNK(3), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK1(2), MAPK3(3), PAPPA(26), RAC1(1), RPS6KA1(1), RPS6KA3(15), SHC1(5), SOS1(10), SYK(3), VAV1(10), VAV2(3), VAV3(9)	10307624	141	53	137	42	44	43	22	11	19	2	0.036	0.11
193	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABARAP(1), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GPHN(11), NSF(2), SRC(2), UBQLN1(4)	4361824	78	35	72	26	21	32	11	4	10	0	0.037	0.12
194	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(3), IL2RG(11), IL4R(5), IRS1(10), JAK1(16), JAK3(5), RPS6KB1(2), SHC1(5), STAT6(5)	5423264	65	38	65	23	14	29	10	3	9	0	0.037	0.12
195	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(8), GALNT10(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT6(1), GALNT7(9), GALNT8(9), GCNT1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), WBSCR17(11)	5177496	70	38	68	24	15	26	16	7	6	0	0.037	0.12
196	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), DBH(7), DCT(11), DDC(9), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HPD(7), MAOA(10), MAOB(5), PNMT(1), TAT(5), TPO(11), TYR(8)	10752536	164	50	156	44	42	58	26	13	25	0	0.040	0.12
197	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(11), GBA3(7), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TPO(11), TYR(8)	3365608	54	29	54	22	17	22	8	1	6	0	0.040	0.13
198	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(9), GLS2(6), GLUD1(3), GLUD2(6)	1506104	24	17	23	8	3	9	4	1	7	0	0.041	0.13
199	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(18), C5(14), C6(13), C7(16), ICAM1(1), IL6(4), IL8(3), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELP(10), SELPLG(7), VCAM1(9)	8782672	130	47	125	34	29	59	14	6	18	4	0.044	0.14
200	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CDO1(4), CSAD(7), GAD1(6), GAD2(10), GGT1(5)	2106264	37	23	37	9	10	9	13	0	5	0	0.045	0.14
201	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(15), AMY2A(4), AMY2B(9), ENPP1(8), ENPP3(14), G6PC(5), GAA(4), GANAB(8), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), MGAM(36), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), RNPC3(6), SI(43), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UXS1(5)	20177776	308	74	305	81	87	101	55	19	46	0	0.047	0.14
202	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(7), GAD1(6), HDC(6), PNMT(1), TPH1(9)	1926216	29	22	28	8	8	7	7	1	4	2	0.050	0.15
203	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(5), IFNGR1(5), IFNGR2(3), JAK1(16), JAK2(14), STAT1(12)	3048168	55	27	54	17	11	17	9	3	11	4	0.052	0.16
204	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(5), GRB2(3), HBXIP(1), PTK2B(13), SHC1(5), SOS1(10), SRC(2)	3088344	39	27	37	11	10	20	4	3	2	0	0.052	0.16
205	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(23), POLA2(1), POLB(3), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLG(5), POLG2(2), POLH(11), POLI(6), POLK(11), POLL(6), POLM(5), POLQ(18), PRIM1(2), PRIM2(7), REV1(9), REV3L(29), RFC5(7)	15226456	171	64	164	38	40	64	28	6	33	0	0.054	0.16
206	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	EEF1B2(3), EEF1D(7), EEF1G(3), EEF2(9), EEF2K(7), EIF1AX(1), EIF2AK1(7), EIF2AK2(13), EIF2AK3(11), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4EBP2(1), EIF4G1(10), EIF4G3(18), EIF5(2), EIF5A(4), EIF5B(12), ETF1(4), GSPT2(14), KIAA0664(11), PABPC1(8), PABPC3(7), PAIP1(3), SLC35A4(4)	14891408	197	67	194	49	51	80	30	8	26	2	0.054	0.16
207	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(12), GNAS(16), GNB1(1), PRKACA(4), PRKAR1A(4)	2146440	37	24	35	6	11	17	3	2	4	0	0.055	0.16
208	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRB1(1), DRD1(5), DRD2(6), EGF(17), EGFR(10), GJA1(5), GJD2(6), GNA11(2), GNAI1(4), GNAI2(4), GNAI3(3), GNAS(16), GRB2(3), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), HTR2A(9), HTR2B(2), HTR2C(13), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), MAP2K1(2), MAP2K5(2), MAP3K2(8), MAPK1(2), MAPK3(3), MAPK7(11), NPR1(10), NPR2(10), NRAS(8), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), PRKX(2), RAF1(5), SOS1(10), SOS2(16), SRC(2), TJP1(18), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3)	46781728	666	110	626	197	189	256	113	31	71	6	0.056	0.16
209	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(16), GNB1(1), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7)	3152328	49	29	46	17	11	23	4	4	7	0	0.056	0.17
210	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(5), IFNGR1(5), JAK1(16), JAK2(14), PTPRU(12), REG1A(2), STAT1(12)	4155240	67	32	66	19	12	25	9	3	14	4	0.057	0.17
211	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD8A(2), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1)	3785472	49	29	49	16	12	22	6	1	8	0	0.060	0.17
212	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(16), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(2), GPRC5D(3), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM7(10), GRM8(17)	7453640	133	45	128	46	45	41	24	5	16	2	0.061	0.18
213	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL4(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR7(6), CD28(3), CD4(6), CXCR3(5), CXCR4(1), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18R1(5), IL2(2), IL4R(5), IL5(1), TGFB1(2), TGFB2(5), TGFB3(8)	7073952	102	43	101	31	17	52	10	7	16	0	0.061	0.18
214	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(3), ATF1(4), CDC42(4), CREB1(5), CREB5(3), DUSP1(2), DUSP10(5), EEF2K(7), EIF4E(2), ELK1(2), IL1R1(4), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K10(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAPK1(2), MAPK13(2), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MKNK1(3), MKNK2(3), MYEF2(5), NFKB1(7), NR2C2(5), SRF(2), TRAF6(3)	11512904	151	53	149	47	38	68	23	9	13	0	0.061	0.18
215	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(6), AARS2(5), ABAT(9), ACY3(3), ADSL(5), ADSS(6), ADSSL1(5), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), ASS1(2), CAD(21), CRAT(2), DARS(4), DARS2(6), DDO(6), DLAT(1), DLD(3), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), NARS2(6), PC(9), PDHA1(4), PDHA2(8), PDHB(3)	13105312	171	59	168	65	42	71	25	10	23	0	0.062	0.18
216	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	126	ACTB(3), ACTG1(1), CHAD(1), COL11A1(22), COL11A2(6), COL17A1(18), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), DES(5), DSC2(11), DSC3(16), DSG1(15), DSG2(7), DSG4(10), FN1(31), GJA1(5), GJA10(6), GJA4(1), GJA8(5), GJA9(10), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GJB7(6), GJC1(1), GJC3(2), GJD2(6), GJD4(3), IBSP(5), INA(3), ITGA6(10), ITGB4(6), KRT1(3), KRT10(1), KRT12(5), KRT13(5), KRT14(4), KRT15(8), KRT16(5), KRT17(4), KRT19(3), KRT2(6), KRT20(4), KRT23(7), KRT24(5), KRT25(4), KRT27(4), KRT28(3), KRT3(7), KRT31(8), KRT32(6), KRT33A(7), KRT33B(2), KRT34(8), KRT35(6), KRT36(6), KRT37(5), KRT38(8), KRT4(10), KRT5(4), KRT6A(3), KRT6B(8), KRT6C(5), KRT7(2), KRT71(3), KRT72(5), KRT73(3), KRT74(1), KRT75(4), KRT76(5), KRT77(4), KRT78(2), KRT79(3), KRT8(2), KRT81(1), KRT82(1), KRT83(2), KRT84(5), KRT85(4), KRT86(1), KRT9(7), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), LMNA(5), LMNB1(4), NES(26), RELN(36), SPP1(2), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VIM(7), VWF(19)	81495280	1079	130	1056	354	297	445	143	52	116	26	0.063	0.18
217	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(3), CD3E(1), CD3G(1), GZMB(2), HLA-A(1), ICAM1(1), ITGAL(12), ITGB2(10), PRF1(6)	2973768	39	27	38	15	8	21	5	0	5	0	0.064	0.18
218	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(6), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHB(2), LDHC(4)	2381792	30	24	29	14	9	10	3	5	3	0	0.066	0.19
219	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CFLAR(5), DAXX(6), DFFB(3), FAF1(6), JUN(1), LMNA(5), LMNB1(4), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), PTPN13(20), RB1(23), RIPK2(5), SPTAN1(23)	15219760	219	57	213	60	62	67	33	11	40	6	0.066	0.19
220	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2)	4131184	53	30	53	16	9	22	6	6	10	0	0.067	0.19
221	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	107	ATP12A(13), ATP4A(6), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), ATP5L(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), COX10(1), COX15(3), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7B2(2), COX7C(2), COX8A(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(6), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(3), NDUFAB1(1), NDUFB1(1), NDUFB10(1), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(10), NDUFS2(4), NDUFS4(2), NDUFS5(1), NDUFS8(2), NDUFV1(2), NDUFV2(2), PPA1(3), PPA2(3), SDHA(10), SDHB(1), SDHC(4), TCIRG1(5), UQCRB(3), UQCRC1(2), UQCRC2(4), UQCRQ(2)	19545872	267	71	263	68	68	117	27	15	40	0	0.068	0.19
222	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(7), DAXX(6), EGF(17), EGFR(10), ETS1(4), ETS2(5), FOS(2), HOXA7(8), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), NFKB1(7), NFKBIA(2), PPP2CA(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), RAF1(5), RELA(4), RIPK1(8), SP1(6), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	17313624	232	63	228	70	46	95	39	15	35	2	0.069	0.19
223	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(7), AGTR2(7), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDK5(1), F2(8), FYN(6), GNA11(2), GNAI1(4), GNB1(1), GRB2(3), JAK2(14), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPT(9), MYLK(10), PLCG1(8), PRKCA(7), PTK2B(13), RAF1(5), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), SYT1(4)	14708880	181	62	175	58	49	72	26	9	21	4	0.069	0.19
224	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	242	ACVR1(9), ACVR1B(5), ACVR2A(5), ACVR2B(5), AMHR2(2), BMP2(5), BMP7(10), BMPR1A(4), BMPR1B(6), BMPR2(9), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(1), CCL28(1), CCL4(1), CCL5(2), CCL7(2), CCL8(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CD27(1), CD40(2), CD40LG(5), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CSF1(3), CSF1R(6), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL12(2), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(5), EGF(17), EGFR(10), EPO(1), EPOR(3), FAS(6), FASLG(5), FLT1(15), FLT3(7), FLT3LG(2), FLT4(9), GDF5(7), GH1(2), GH2(2), GHR(8), HGF(13), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL15(1), IL17RA(3), IL17RB(3), IL18(1), IL18R1(5), IL18RAP(11), IL19(1), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL25(1), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL8(3), IL9R(1), INHBA(3), INHBB(2), INHBC(1), INHBE(4), KDR(20), KIT(22), KITLG(2), LEP(1), LEPR(10), LIF(2), LIFR(19), LTA(2), LTBR(5), MET(9), MPL(4), NGFR(3), OSM(1), OSMR(11), PDGFB(2), PDGFC(2), PDGFRA(19), PDGFRB(10), PF4(1), PF4V1(1), PLEKHO2(3), PRL(4), PRLR(3), RELT(1), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF11A(4), TNFRSF11B(6), TNFRSF13B(1), TNFRSF14(2), TNFRSF19(3), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF8(6), TNFRSF9(1), TNFSF11(5), TNFSF12(4), TNFSF13B(2), TNFSF14(2), TNFSF15(2), TNFSF18(3), TNFSF4(3), TNFSF8(1), TPO(11), TSLP(1), VEGFB(2), VEGFC(6), XCL2(1), XCR1(3)	62425320	846	119	830	260	230	326	127	47	112	4	0.070	0.19
225	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(1), AKR1B10(3), B4GALT1(2), B4GALT2(3), G6PC(5), G6PC2(4), GAA(4), GALK1(1), GALK2(2), GALT(2), GANC(13), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), HSD3B7(3), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4), RDH11(1), RDH12(3), RDH13(4), RDH14(2), UGP2(5)	12895752	169	59	167	61	45	68	22	14	20	0	0.070	0.19
226	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3D(3), CD3E(1), CD3G(1), IFNG(5), IL2(2), IL2RA(2), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), TOB1(2), TOB2(5)	3856896	56	30	56	22	11	27	8	3	7	0	0.071	0.19
227	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(11), CKM(2), EIF4E(2), FBL(2), LDHA(6), LDHB(2), LDHC(4), MAPK14(4), NCL(3)	3089336	36	26	36	19	9	12	4	4	5	2	0.072	0.20
228	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(9), NR3C1(11), PPARG(5), RETN(1), RXRA(1)	2049472	30	21	30	6	10	8	2	2	8	0	0.074	0.20
229	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(6), CHUK(7), IFNG(5), IKBKB(8), IL2(2), JUN(1), MAP3K1(24), MAP3K5(19), MAP4K5(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(1), TRAF2(2)	7099496	105	37	101	30	24	43	10	8	18	2	0.074	0.20
230	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(11), GBA(3), GBA3(7), LPO(4), MPO(6), PRDX6(2), TPO(11)	2960624	44	27	44	20	16	15	6	1	6	0	0.076	0.20
231	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL2(2), IL2RA(2), IL2RB(1), IL2RG(11), JAK1(16), JAK3(5), JUN(1), LCK(3), MAP2K1(2), MAPK3(3), MAPK8(7), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3)	8416128	95	45	92	23	28	38	12	6	11	0	0.077	0.20
232	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(12), ADRB2(5), GNAS(16), PLCE1(31), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	4951568	85	37	81	22	19	35	15	4	12	0	0.077	0.20
233	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(5), ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG6(3), ALG8(5), ALG9(5), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT5(2), B4GALT7(3), C1GALT1(2), C1GALT1C1(4), CHPF(3), CHST1(8), CHST11(7), CHST12(3), CHST14(2), CHST2(1), CHST3(3), CHST4(1), CHST7(4), DAD1(1), DDOST(3), DPAGT1(2), EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), FUT11(4), FUT8(12), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GANAB(8), GCNT1(3), GCNT3(3), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), NDST1(11), NDST2(4), NDST3(12), NDST4(11), OGT(13), RPN1(2), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST6GAL1(6), ST6GALNAC1(2), STT3B(3), UST(3), WBSCR17(11), XYLT1(10), XYLT2(3)	38453144	517	91	495	162	129	213	89	24	58	4	0.082	0.21
234	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(6), CNR2(3), DNMT1(11), MTNR1A(4), MTNR1B(3), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2)	3602696	57	32	55	22	14	28	8	4	3	0	0.082	0.21
235	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(4), GRIA2(17), PPP1R1B(2)	1266536	24	17	23	5	4	8	5	0	7	0	0.083	0.22
236	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(6), CASP1(5), CASP3(3), CASP7(4), CASP8(12), GAPDH(2), INSR(12), ITCH(7), MAGI1(20), MAGI2(23), RERE(13), WWP1(12), WWP2(4)	8327344	123	43	120	37	23	60	17	4	17	2	0.083	0.22
237	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(5), GSTZ1(4)	480872	9	8	9	1	0	6	1	1	1	0	0.084	0.22
238	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(16), BDKRB1(2), BDKRB2(7), C1QA(4), C1QB(2), C1QC(4), C1R(9), C1S(5), C2(3), C3(18), C3AR1(7), C4BPA(6), C4BPB(2), C5(14), C5AR1(3), C6(13), C7(16), C8A(9), C8B(3), C9(18), CD46(1), CD55(5), CD59(3), CFB(3), CFH(15), CFI(6), CPB2(6), CR1(18), CR2(19), F10(9), F11(9), F12(2), F13A1(7), F13B(13), F2(8), F2R(6), F3(6), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), KNG1(7), MASP1(9), MASP2(5), MBL2(3), PLAT(5), PLAU(4), PLAUR(5), PLG(9), PROC(3), PROS1(1), SERPINA1(3), SERPINA5(3), SERPINC1(5), SERPIND1(4), SERPINE1(5), SERPINF2(4), SERPING1(6), TFPI(7), VWF(19)	32498168	531	86	507	152	141	218	73	28	63	8	0.085	0.22
239	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(4), CSF1(3), IL6(4), LDLR(6), LPL(9)	1946552	26	20	26	6	8	9	3	1	5	0	0.086	0.22
240	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TAT(5), TPO(11)	7821672	110	41	104	42	28	38	16	9	19	0	0.091	0.23
241	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(18), CR2(19), FCGR2B(3), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11)	5514032	79	37	79	22	23	32	10	3	9	2	0.099	0.25
242	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), CAT(3), EPX(11), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11)	4054056	49	31	49	22	15	21	6	1	6	0	0.100	0.25
243	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(12), DYRK1B(2), GLI2(7), GLI3(14), GSK3B(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SHH(4), SMO(5), SUFU(3)	5711192	76	35	75	36	22	34	5	4	9	2	0.10	0.25
244	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5)	3288232	44	25	44	17	8	19	4	3	10	0	0.10	0.25
245	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5)	3288232	44	25	44	17	8	19	4	3	10	0	0.10	0.25
246	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(5), ALOX15(7), ALOX5(6), CBR1(1), CBR3(1), CYP4F2(8), CYP4F3(7), EPX(11), GGT1(5), LPO(4), LTA4H(4), MPO(6), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PRDX2(4), PRDX5(1), PRDX6(2), PTGDS(4), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4), TPO(11)	9577512	134	49	131	48	39	61	17	4	13	0	0.10	0.26
247	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(6)	898752	9	9	9	4	1	5	0	0	3	0	0.10	0.26
248	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(26), ABCB11(13), ABCB4(24), ABCC1(12), ABCC3(8), GSTP1(2)	5399952	85	34	82	30	26	23	13	7	14	2	0.10	0.26
249	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CHEK1(2), WEE1(1), YWHAH(2)	4999184	61	31	58	10	13	17	13	0	14	4	0.10	0.26
250	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(10), ACO2(5), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), PC(9), PCK1(8), SDHA(10), SDHB(1), SUCLA2(5), SUCLG1(3), SUCLG2(10)	7464056	108	44	107	46	32	46	13	8	9	0	0.11	0.26
251	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(25), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADIPOQ(2), ADIPOR2(7), AGRP(2), AKT1(3), AKT2(4), AKT3(7), CAMKK1(9), CAMKK2(6), CD36(5), CHUK(7), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), G6PC(5), G6PC2(4), IKBKB(8), IRS1(10), IRS4(16), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), MAPK10(7), MAPK8(7), MAPK9(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NPY(2), PCK1(8), PCK2(7), POMC(1), PPARGC1A(8), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKCQ(6), PTPN11(5), RELA(4), RXRA(1), RXRG(6), SLC2A1(2), SLC2A4(5), STAT3(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2), TYK2(4)	29134544	381	84	374	131	75	168	63	17	50	8	0.11	0.26
252	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(1), ANXA3(3), ANXA4(8), ANXA5(2), ANXA6(8), CYP11A1(7), EDN1(2), EDNRA(5), HPGD(2), HSD11B1(3), PLA2G4A(9), PRL(4), PTGDR(6), PTGDS(4), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), PTGIS(6), PTGS1(5), PTGS2(6), SCGB1A1(1), TBXAS1(4)	7501256	110	42	110	30	33	40	15	7	15	0	0.11	0.26
253	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	ATF2(6), BRAF(9), CHUK(7), CREB1(5), DAXX(6), ELK1(2), FOS(2), GRB2(3), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP3K9(3), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAP4K5(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK4(3), MAPK6(7), MAPK7(11), MAPK8(7), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MKNK2(3), MYC(6), NFKB1(7), NFKBIA(2), PAK1(1), PAK2(3), RAC1(1), RAF1(5), RELA(4), RIPK1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KB1(2), RPS6KB2(4), SHC1(5), SP1(6), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2)	33131560	449	89	441	115	105	190	53	29	68	4	0.11	0.27
254	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(5), IFNG(5), IL12A(5), IL12B(2), IL18(1), IL2(2)	1135344	20	16	19	6	6	7	3	2	2	0	0.11	0.27
255	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(11), BID(2), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CYCS(2), DFFB(3), GAS2(6), LMNA(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF10A(2), TNFRSF10B(4), TNFRSF25(1), TNFSF12(4), TRAF2(2)	11713288	146	52	142	41	40	52	18	4	32	0	0.11	0.27
256	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(9), GOT1(5), GOT2(3), TAT(5), TYR(8)	1696816	30	19	30	3	5	14	5	4	2	0	0.12	0.28
257	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(17), EGFR(10), MAP2K1(2), MAP3K1(24), MAPK14(4), NCOR2(16), RARA(1), RXRA(1), THRA(4), THRB(2)	5496176	81	36	79	28	18	27	13	9	12	2	0.12	0.28
258	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6)	7810512	106	44	102	33	21	50	12	5	18	0	0.12	0.28
259	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6)	7810512	106	44	102	33	21	50	12	5	18	0	0.12	0.28
260	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18)	4487560	88	31	83	19	16	37	15	5	11	4	0.12	0.28
261	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(7), IKBKB(8), IL1R1(4), IRAK1(4), MAP3K1(24), MAP3K14(4), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TLR4(13), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3)	8543600	104	42	103	26	26	35	13	8	20	2	0.12	0.29
262	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(6), CDO1(4), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), SDS(1), SULT1B1(4), SULT1C2(4), SULT1C4(3), SULT4A1(3)	4366784	58	32	55	29	20	16	10	6	6	0	0.12	0.29
263	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AGPS(9), CHPT1(1), ENPP2(18), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH2(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PPAP2A(4), PPAP2B(2)	7958568	106	43	103	29	23	48	11	4	18	2	0.12	0.29
264	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(4), IL6R(7), JAK1(16), JAK2(14), JAK3(5), PIAS3(7), PTPRU(12), REG1A(2), SRC(2), STAT3(8)	5459968	78	34	77	22	13	31	13	3	14	4	0.12	0.29
265	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(10), AP2A1(6), AP2M1(5), BIN1(3), CALM2(3), DNM1(4), EPN1(7), EPS15(8), PICALM(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYNJ1(24), SYNJ2(8), SYT1(4)	7812248	102	43	99	41	27	38	16	5	16	0	0.13	0.29
266	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(1), ITGAL(12), ITGAM(19), ITGB2(10), SELE(5), SELL(3)	4301064	54	31	53	22	12	23	6	2	9	2	0.13	0.29
267	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(3), CHUK(7), EGR2(4), EGR3(5), MAP3K1(24), MYC(6), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), SYT1(4), VIP(1)	9629096	116	45	113	35	29	46	11	12	16	2	0.13	0.30
268	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(27), ACACB(25), MCAT(2), OLAH(7), OXSM(5)	4386624	66	33	63	21	20	22	11	1	8	4	0.13	0.31
269	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), RRM1(2), RRM2(5), TK1(1), TK2(6), TXNRD1(9), UCK1(5), UCK2(5), UMPS(5), UNG(1), UPB1(8), UPP1(3)	19896792	226	67	221	69	44	95	32	19	36	0	0.13	0.31
270	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(42), BMPR1B(6), CCND2(7), CDK4(3), CDKN1B(6), DAZL(5), DMC1(4), EGR1(6), ESR2(4), FSHR(14), GJA4(1), INHA(1), LHCGR(14), MLH1(7), MSH5(7), NCOR1(16), NRIP1(14), PGR(10), PRLR(3), PTGER2(2), SMPD1(10), VDR(7), ZP2(11)	12424800	200	51	192	50	44	75	29	5	41	6	0.14	0.31
271	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AICDA(2), AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), NME7(2), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PRIM1(2), PRIM2(7), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), TK1(1), TK2(6), TXNRD1(9), TXNRD2(4), UCK1(5), UCK2(5), UMPS(5), UPB1(8), UPP1(3), UPP2(4), UPRT(6)	28865960	336	78	327	111	70	130	52	28	56	0	0.14	0.31
272	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7)	3519864	38	27	38	13	7	22	4	0	5	0	0.14	0.31
273	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(11), CD14(2), CD19(3), CD1A(5), CD1B(1), CD1C(11), CD1D(3), CD1E(5), CD2(4), CD22(11), CD33(6), CD34(1), CD36(5), CD37(1), CD38(5), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD44(4), CD5(5), CD55(5), CD59(3), CD8A(2), CD8B(1), CD9(3), CR1(18), CR2(19), CSF1(3), CSF1R(6), CSF2RA(7), CSF3(1), CSF3R(7), DNTT(1), EPO(1), EPOR(3), FCGR1A(5), FLT3(7), FLT3LG(2), GP1BA(9), GP5(2), GYPA(1), HLA-DRB5(2), IL11RA(5), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL7(1), IL7R(7), IL9R(1), ITGA1(13), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGAM(19), ITGB3(10), KIT(22), KITLG(2), MME(6), MS4A1(5), TFRC(3), THPO(5), TPO(11)	30199704	411	84	404	132	116	151	55	22	61	6	0.14	0.31
274	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(3), BIRC3(2), CASP8(12), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	2831416	32	22	31	10	5	11	5	1	10	0	0.14	0.32
275	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(12), ADRB2(5), CFTR(12), GNAS(16), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SLC9A3R1(2)	4327104	68	32	64	16	16	31	7	3	11	0	0.15	0.33
276	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	90	ANK2(26), B3GALT4(3), CDR1(2), DGKI(16), FAU(1), IL6ST(6), MRPL19(5), PIGK(6), RPL10(4), RPL11(1), RPL14(7), RPL15(1), RPL17(5), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22(3), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL4(3), RPL5(5), RPL6(2), RPL8(1), RPL9(1), RPLP0(4), RPS10(1), RPS12(2), RPS13(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS27A(3), RPS29(2), RPS3(2), RPS3A(1), RPS4X(1), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), RPS7(3), RPS8(2), RPS9(1), SLC36A2(5), TBC1D10C(1), TSPAN9(3), UBB(1), UBC(7)	18571480	237	64	224	85	63	86	36	14	38	0	0.15	0.33
277	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(3), AP2A1(6), AP2M1(5), ARF1(3), BAD(2), BTK(4), EEA1(16), GRASP(3), GSK3A(8), GSK3B(8), LYN(6), PDPK1(2), PFKM(4), PFKP(6), PLCG1(8), PRKCE(7), PRKCZ(3), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(3)	8307752	101	45	97	40	33	37	15	5	11	0	0.15	0.33
278	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	187984	3	3	3	0	2	0	0	0	1	0	0.15	0.33
279	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	1712192	21	18	21	6	7	9	3	1	1	0	0.15	0.33
280	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(2), CREBBP(24), DFFB(3), GZMA(6), GZMB(2), HMGB2(4), PRF1(6), SET(4)	3740832	53	29	51	18	8	21	8	4	12	0	0.15	0.34
281	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(21), GNA12(7), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3)	3613856	43	29	41	14	8	18	5	4	8	0	0.16	0.34
282	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(2), IL5(1), MAF(2), MAP2K3(7), MAPK14(4), NFATC2(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	3646096	46	27	45	17	6	23	4	6	7	0	0.16	0.34
283	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), CARM1(4), DBH(7), DCT(11), DDC(9), ECH1(2), ESCO1(8), ESCO2(5), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HEMK1(1), HPD(7), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NAT6(1), PNMT(1), PNPLA3(6), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SH3GLB1(6), TAT(5), TPO(11), TYR(8), TYRP1(7), WBSCR22(5)	20674520	253	65	243	69	65	90	40	16	42	0	0.16	0.35
284	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), B4GALT2(3), G6PC(5), GAA(4), GALK1(1), GALK2(2), GALT(2), GANAB(8), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4)	11222992	139	52	138	57	38	55	18	10	18	0	0.16	0.36
285	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), LTA(2), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFAIP3(2), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4)	8127952	92	39	91	23	21	38	7	8	16	2	0.16	0.36
286	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(12), GNAS(16), GNB1(1), PPP2CA(4), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	5127896	78	34	75	20	17	41	7	3	10	0	0.17	0.36
287	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(4), DLG4(10), EPHB2(8), F2(8), F2RL1(2), F2RL2(2), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(11), MAPK8(7), MYEF2(5), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RAF1(5), RASAL1(11), SRC(2), TEC(5), VAV1(10)	9655136	121	47	120	47	33	45	21	3	19	0	0.17	0.36
288	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(4), CD3D(3), CD3E(1), CD3G(1), CD4(6), CXCR3(5), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), JAK2(14), STAT4(6), TYK2(4)	5174520	75	33	74	26	13	28	11	7	12	4	0.18	0.38
289	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BTRC(11), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK1G1(5), CSNK1G3(6), DHH(2), FBXW11(4), GLI1(8), GLI2(7), GLI3(14), GSK3B(8), HHIP(11), IHH(3), LRP2(61), PRKACA(4), PRKACG(7), PRKX(2), PTCH1(17), PTCH2(12), RAB23(2), SHH(4), SMO(5), STK36(6), SUFU(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1), ZIC2(1)	20735280	293	72	285	95	98	118	36	11	30	0	0.18	0.38
290	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(3), EPX(11), LPO(4), MPO(6), MTHFR(5), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11)	4035952	48	29	48	20	15	18	6	1	8	0	0.18	0.38
291	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(3), CASP8(12), CFL1(1), CFLAR(5), PDE6D(1)	1352592	22	14	21	9	4	7	4	1	6	0	0.18	0.39
292	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(3), SLPI(2)	633144	9	9	8	0	3	3	2	0	1	0	0.19	0.40
293	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(3), AKT3(7), CAPN1(2), CAPN10(7), CAPN11(6), CAPN2(5), CAPN3(8), CAPN5(6), CAPN6(4), CAPN7(4), CAPN9(8), CAPNS1(1), CAV2(1), CDC42(4), CRK(1), CSK(1), DOCK1(17), FYN(6), GIT2(6), GRB2(3), ILK(4), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAPK10(7), MAPK4(3), MAPK6(7), MAPK7(11), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAP1B(2), RAPGEF1(9), RHO(3), ROCK1(15), ROCK2(10), SDCCAG8(11), SEPP1(3), SHC1(5), SHC3(9), SORBS1(14), SOS1(10), SRC(2), TLN1(20), TNS1(15), VASP(1), VAV2(3), VAV3(9), VCL(8), ZYX(11)	47185968	557	97	543	216	154	216	74	30	73	10	0.19	0.40
294	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(5), CREM(3), FOS(2), JUN(1), MAPK3(3), OPRK1(6), POLR2A(17), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	4489296	58	31	57	18	11	30	6	4	7	0	0.19	0.40
295	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(6), CD80(5), IL10(2), IL2(2)	1493952	18	13	18	9	4	8	3	0	3	0	0.20	0.42
296	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD36(5), CD44(4), CD47(5), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), DAG1(4), FN1(31), FNDC1(20), FNDC3A(6), FNDC4(1), FNDC5(1), GP1BA(9), GP5(2), GP6(2), HMMR(12), HSPG2(16), IBSP(5), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), RELN(36), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SPP1(2), SV2A(10), SV2B(10), SV2C(9), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VWF(19)	77138416	932	121	915	319	237	382	121	55	113	24	0.20	0.42
297	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4)	3800848	52	26	52	17	8	15	12	4	9	4	0.20	0.42
298	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4)	3800848	52	26	52	17	8	15	12	4	9	4	0.20	0.42
299	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(3), ARSB(4), FUCA1(2), FUCA2(3), GBA(3), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NAGLU(2), NEU2(4), NEU3(2), SPAM1(11)	11804304	128	49	127	56	33	59	17	8	11	0	0.20	0.42
300	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(7), ALOX5(6), CYP1A2(5), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), HSD3B7(3), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	8490776	105	44	104	28	29	39	18	4	15	0	0.21	0.43
301	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(11), ARHGDIB(1), BIRC2(10), BIRC3(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), DFFB(3), GZMB(2), LMNA(5), LMNB1(4), PRF1(6)	6682360	92	34	87	26	25	31	14	2	20	0	0.21	0.44
302	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(7), ACADM(4), ACADS(4), ACADVL(4), ACSL1(9), ACSL3(6), ACSL4(17), CPT1A(6), CPT2(4), EHHADH(4), HADHA(5), PECR(4), SCP2(8), SLC25A20(3)	6056408	85	34	82	23	20	28	18	6	13	0	0.22	0.45
303	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(5), ADSS(6), DHFR(3), HPRT1(2), IMPDH1(5), MTHFD2(2), POLB(3), POLD1(11), POLG(5), PRPS2(6), RRM1(2), SRM(1)	4275768	51	29	50	19	14	23	6	4	4	0	0.22	0.45
304	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(9), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GLS(9), GLS2(6), GLUD1(3), GLUL(6), GMPS(11), GOT1(5), GOT2(3), GPT2(4), GSS(3), NADSYN1(6), PPAT(7), QARS(4)	11630208	160	51	155	46	29	67	26	10	24	4	0.22	0.45
305	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(4), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), IL2(2), IL2RA(2), IL4R(5)	4682488	61	31	60	19	13	27	5	6	10	0	0.23	0.47
306	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(8), ERBB4(19), NRG2(2), NRG3(11), PRKCA(7), PSEN1(5)	3201680	52	24	51	19	10	21	9	6	6	0	0.24	0.48
307	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), RFK(1), TYR(8)	3529288	49	25	49	13	11	19	12	5	2	0	0.24	0.49
308	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(3), BIRC2(10), BIRC3(2), CASP3(3), CASP8(12), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(8), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR2C2(5), RALBP1(4), RIPK1(8), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	9320336	105	43	103	29	21	44	17	4	19	0	0.25	0.49
309	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(27), ACACB(25), ACADM(4), ACAT1(4), ACAT2(4), ACSS1(3), ACSS2(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(6), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SUCLA2(5), SUCLG1(3), SUCLG2(10)	14300424	177	54	172	48	47	63	29	13	23	2	0.25	0.49
310	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(2), ALOX12(5), ALOX12B(8), ALOX15(7), ALOX15B(5), ALOX5(6), CBR1(1), CBR3(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(5), CYP4F2(8), CYP4F3(7), EPHX2(5), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PTGDS(4), PTGES(2), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4)	13418288	177	54	173	50	49	77	25	8	18	0	0.25	0.49
311	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(11), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP7(4), CASP8(12), CASP9(2), DFFB(3), GZMB(2), PRF1(6), SCAP(10), SREBF1(2), SREBF2(8)	6073024	83	36	79	26	24	26	11	3	19	0	0.25	0.49
312	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(5), PRKCA(7), TGM2(6)	1835696	23	19	23	14	9	6	3	3	2	0	0.25	0.49
313	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME3(6), PGK1(5), PGK2(2), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4), TKTL1(7), TKTL2(12)	6775112	94	38	91	32	24	40	11	6	13	0	0.25	0.50
314	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(9), ADC(5), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EARS2(3), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GFPT2(10), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), GMPS(11), GNPNAT1(1), GOT1(5), GOT2(3), GPT2(4), GSR(4), GSS(3), NADSYN1(6), NAGK(1), PPAT(7), QARS(4)	13876096	190	55	185	59	38	83	27	10	28	4	0.25	0.50
315	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3)	2161072	26	20	26	13	6	13	4	1	2	0	0.26	0.50
316	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3)	2161072	26	20	26	13	6	13	4	1	2	0	0.26	0.50
317	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3)	8473168	86	38	85	27	20	32	9	9	16	0	0.26	0.50
318	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(5)	676792	11	9	10	7	4	3	1	0	3	0	0.26	0.50
319	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(3), ADAM17(8), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CCL5(2), CDC42(4), CHUK(7), CSK(1), CXCL1(1), EGFR(10), F11R(1), GIT1(8), HBEGF(2), IGSF5(6), IKBKB(8), IL8(3), JAM2(7), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(4), MAPK10(7), MAPK13(2), MAPK14(4), MAPK8(7), MAPK9(4), MET(9), NFKB1(7), NFKB2(9), NFKBIA(2), NOD1(7), PAK1(1), PLCG1(8), PLCG2(23), PTPN11(5), PTPRZ1(35), RAC1(1), RELA(4), SRC(2), TCIRG1(5), TJP1(18)	24767512	350	72	344	110	78	154	47	17	52	2	0.27	0.51
320	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNB1(1), HTR2C(13), PLCB1(4), TUB(11)	2571016	32	23	31	10	11	11	6	3	1	0	0.27	0.51
321	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(6), ENO1(4), GPI(5), HK1(9), PGAM1(1), PGK1(5), PKLR(5)	2672696	35	21	34	10	10	13	3	2	7	0	0.27	0.51
322	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2)	7077176	79	39	78	28	20	34	13	5	7	0	0.27	0.51
323	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(5), GOT2(3), TAT(5)	934216	13	11	13	2	2	5	2	4	0	0	0.28	0.53
324	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(6), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH9A1(1), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HMGCL(2), L2HGDH(3), OXCT1(8), PDHA1(4), PDHA2(8), PDHB(3), SDHB(1), SDS(1)	9084736	114	44	111	33	26	45	17	10	16	0	0.28	0.53
325	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(4), BAD(2), BRAF(9), CREB1(5), CREB5(3), DUSP6(1), DUSP9(1), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(2), MAP3K8(6), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(7), RAP1A(3), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), SHC1(5), SOS1(10), SOS2(16), TRAF3(4)	10345816	137	49	133	42	33	53	23	10	16	2	0.28	0.53
326	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2)	5744672	64	34	63	23	16	23	13	5	7	0	0.28	0.53
327	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(9), COPS5(5), CREB1(5), EDN1(2), EP300(23), EPO(1), HIF1A(12), JUN(1), LDHA(6), NOS3(6), VHL(2)	5812624	74	31	73	11	20	22	14	4	14	0	0.28	0.53
328	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(13)	2451480	31	21	30	19	9	13	4	4	1	0	0.28	0.53
329	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(10), ACO2(5), AFMID(4), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2)	4881880	60	32	59	23	23	21	7	5	4	0	0.29	0.53
330	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(7), F2(8), F2R(6), FGA(23), FGB(4), FGG(9), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5)	4928008	92	34	88	22	32	28	20	5	7	0	0.29	0.54
331	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(4), ASL(2), CPS1(19), GLS(9), GLUD1(3), GOT1(5)	2720064	42	21	40	11	8	17	5	2	6	4	0.29	0.54
332	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(9), F2(8), F2R(6), F3(6), F5(36), F7(1), FGA(23), FGB(4), FGG(9), PROC(3), PROS1(1), SERPINC1(5), TFPI(7)	5748144	118	35	113	24	40	43	19	7	9	0	0.29	0.54
333	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(3), DLG4(10), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), NOS1(14), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), SYT1(4)	8881624	119	44	117	60	25	53	23	6	12	0	0.30	0.55
334	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(15), CAPN1(2), CAPNS1(1), CAPNS2(3), CDK5(1), CDK5R1(2), CSNK1A1(4), GSK3B(8), MAPT(9), PPP2CA(4)	3212592	49	24	48	14	11	25	6	1	6	0	0.30	0.55
335	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(7), CYP11B2(5), CYP17A1(1), HSD11B1(3), HSD3B1(1), HSD3B2(5)	2552664	26	20	26	12	6	10	2	1	7	0	0.30	0.55
336	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), AOX1(14), BCAT1(5), BCKDHA(4), BCKDHB(2), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), HIBADH(3), HMGCL(2), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), PCCA(6), PCCB(7), SDS(1)	12613032	144	50	142	50	35	56	25	11	17	0	0.30	0.55
337	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(10), ACO2(5), CLYBL(7), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), OGDHL(15), PC(9), PCK1(8), PCK2(7), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10)	10859424	156	51	152	60	38	71	21	12	14	0	0.30	0.55
338	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(21), APOC1(1), APOE(1), CETP(4), CYP7A1(10), HMGCR(9), LCAT(2), LDLR(6), LIPC(5), LPL(9), LRP1(36), SCARB1(6), SOAT1(7)	9114496	117	47	115	30	36	50	15	6	10	0	0.30	0.55
339	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(6), IFNB1(2), JAK1(16), PTPRU(12), REG1A(2), STAT1(12), STAT2(5), TYK2(4)	4487064	59	30	58	20	12	24	10	5	8	0	0.31	0.56
340	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(11), BAD(2), BAX(3), BCL2L1(3), BCL2L2(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CD40(2), CD40LG(5), CRADD(2), CYCS(2), DAXX(6), DFFB(3), FAS(6), FASLG(5), IKBKE(1), LTA(2), MCL1(1), NFKB1(7), NFKBIA(2), NGFR(3), NR3C1(11), NTRK1(11), PTPN13(20), RIPK1(8), TFG(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4), TRAF6(3)	15656736	185	52	182	54	50	69	28	7	31	0	0.31	0.56
341	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP2(6), MMP9(11), RECK(13), TIMP1(3), TIMP2(1), TIMP3(8), TIMP4(1)	2711136	46	24	45	17	15	18	7	1	5	0	0.31	0.56
342	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(3), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), ILVBL(7), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCDC(1), PPCS(4), UPB1(8), VNN1(6)	5983248	96	35	94	21	28	34	17	6	11	0	0.31	0.56
343	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(4), ACADL(7), ACADM(4), ACOX1(3), ACOX2(6), ACOX3(5), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADIPOQ(2), APOA2(1), APOA5(1), AQP7(4), CD36(5), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP27A1(8), CYP4A11(4), CYP4A22(5), CYP7A1(10), CYP8B1(4), DBI(1), EHHADH(4), FABP1(4), FABP2(2), FABP3(1), FABP5(3), FABP6(3), FABP7(2), FADS2(1), GK(13), GK2(18), HMGCS2(6), ILK(4), LPL(9), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK1(8), PCK2(7), PDPK1(2), PLTP(3), PPARD(3), PPARG(5), RXRA(1), RXRG(6), SCD(6), SCP2(8), SLC27A1(8), SLC27A2(2), SLC27A4(3), SLC27A5(3), SLC27A6(9), SORBS1(14), UBC(7), UCP1(1)	23464024	324	70	317	86	84	132	52	17	39	0	0.31	0.56
344	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(2), EGFR(10), ELK1(2), GNAS(16), GNB1(1), GRB2(3), IGF1R(10), ITGB1(5), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(6), NGFR(3), PDGFRA(19), PPP2CA(4), PTPRR(13), RAF1(5), RPS6KA1(1), RPS6KA5(7), SHC1(5), SOS1(10), SRC(2), STAT3(8)	11406016	147	50	142	32	35	63	23	9	15	2	0.32	0.57
345	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(27), ACADL(7), ACADM(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), LDHA(6), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SDS(1), SUCLA2(5), SUCLG1(3), SUCLG2(10)	11894824	151	49	149	46	36	51	28	13	23	0	0.32	0.57
346	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(5), DLAT(1), DLD(3), DLST(8), FH(8), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), PC(9), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PDK1(2), PDK2(3), PDK3(10), PDK4(7), PDP2(4), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10)	10220576	149	47	147	51	37	66	18	10	18	0	0.32	0.57
347	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	12	NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2)	2343848	35	21	34	8	11	17	2	2	3	0	0.33	0.58
348	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM2(3), CCL4(1), CXCL12(2), CXCR4(1), FOS(2), JUN(1), MAPK14(4), MAPK8(7), PLCG1(8), PRKCA(7), PTK2B(13), SYT1(4)	4736304	53	29	52	25	16	17	7	6	7	0	0.33	0.58
349	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(10), ACO2(5), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SDHB(1), SUCLA2(5)	3250536	42	26	42	23	12	18	3	5	4	0	0.33	0.58
350	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(4), ARSD(6), ARSE(5), ASAH1(6), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SMPD1(10), SMPD2(4), SPTLC1(5), SPTLC2(4), UGCG(4)	8156720	103	40	102	31	26	51	7	8	11	0	0.33	0.58
351	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), PHPT1(1), RFK(1), TYR(8)	5416816	77	31	76	22	15	28	17	5	12	0	0.33	0.59
352	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(8), AGT(7), AGTR2(7), EDN1(2), EDNRA(5), EGF(17), EGFR(10), FOS(2), JUN(1), MYC(6), NFKB1(7), PLCG1(8), PRKCA(7), RELA(4)	7517376	91	39	87	35	18	43	16	7	7	0	0.34	0.59
353	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(4), CYB5R3(5), GCK(3), GFPT1(8), GNE(8), GNPDA1(1), GNPDA2(6), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), PGM3(4), RENBP(3), UAP1(5)	6044752	73	35	72	30	18	24	14	7	10	0	0.34	0.59
354	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PGK1(5), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4)	6047728	78	34	76	26	20	32	12	5	9	0	0.34	0.60
355	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(1), CDC7(10), CDK2(2), DIAPH2(18), GMNN(2), MCM10(5), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), NACA(17), PCNA(2), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), PRIM1(2), RFC1(13), RFC2(3), RFC3(4), RFC4(3), RFC5(7), RPA1(5), RPA2(2), RPA3(3), RPA4(4), RPS27A(3), UBB(1), UBC(7)	17802184	170	58	163	42	58	65	17	7	23	0	0.34	0.60
356	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(4), ACAA2(2), ACADM(4), ACADS(4), ACAT1(4), ACAT2(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), AOX1(14), AUH(3), BCAT1(5), BCAT2(3), BCKDHA(4), BCKDHB(2), DBT(3), DLD(3), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HADHB(3), HIBADH(3), HIBCH(6), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), OXCT2(2), PCCA(6), PCCB(7)	15176856	169	54	166	49	42	68	32	11	16	0	0.35	0.60
357	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(8), DLL1(6), FURIN(4), PSEN1(5)	1817592	23	16	23	11	3	14	1	1	4	0	0.35	0.60
358	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELE(5), SELL(3)	4849640	48	29	48	22	15	16	7	4	6	0	0.36	0.61
359	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(3), ACTA2(5), ACTN2(7), ACTN3(6), ACTN4(6), DES(5), DMD(67), FAM48A(3), MYBPC1(13), MYBPC2(5), MYBPC3(10), MYH3(20), MYH6(12), MYH7(26), MYH8(25), MYL1(5), MYL2(1), MYL9(3), MYOM1(29), NEB(101), TMOD1(2), TNNC2(3), TNNI1(1), TNNI3(2), TNNT1(3), TNNT2(6), TPM1(2), TPM3(4), TPM4(3), TTN(439), VIM(7)	50949616	824	103	795	231	231	301	125	48	51	68	0.36	0.61
360	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(11), ARHGAP5(18), ARHGDIB(1), CASP1(5), CASP10(8), CASP3(3), CASP8(12), CASP9(2), CYCS(2), GZMB(2), JUN(1), PRF1(6)	4739776	71	28	68	18	17	22	11	3	16	2	0.36	0.61
361	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(1), CANX(4), CD4(6), CD8A(2), CD8B(1), CIITA(12), CREB1(5), CTSL1(4), CTSS(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(6), HSP90AB1(17), HSPA5(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), KIR2DL1(4), KIR2DL4(2), KIR2DS4(5), KIR3DL1(6), KIR3DL2(3), KIR3DL3(2), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), LGMN(4), LTA(2), NFYA(6), NFYB(2), NFYC(1), PDIA3(3), PSME1(1), PSME2(1), RFX5(6), RFXANK(3), RFXAP(2), TAP1(6), TAPBP(4)	17171024	184	56	179	48	42	86	21	8	27	0	0.36	0.61
362	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACADVL(4), ACAT1(4), ACAT2(4), ACOX1(3), ACOX3(5), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(5), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8)	17435392	200	54	196	50	45	79	39	11	26	0	0.36	0.61
363	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(27), CPT1A(6), LEP(1), LEPR(10), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3)	5292568	68	31	67	20	20	26	8	3	11	0	0.36	0.62
364	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(5), ACADL(7), ACADM(4), ACADSB(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), MLYCD(3), SDS(1), SMS(7), UPB1(8)	10426168	133	47	130	51	39	39	23	13	19	0	0.37	0.63
365	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(7), ARSB(4), ARSD(6), ARSE(5), CYP11B1(4), CYP11B2(5), HSD11B1(3), HSD17B2(2), HSD17B3(5), HSD17B8(2), HSD3B1(1), HSD3B2(5), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7)	9646456	133	44	126	40	40	50	15	13	15	0	0.37	0.63
366	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(3), CAMK1(2), CAMK1G(3), ELK1(2), FPR1(1), GNA15(1), GNB1(1), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(4), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PAK1(1), PIK3C2G(12), PLCB1(4), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAC1(1), RAF1(5), RELA(4), SYT1(4)	13463424	144	52	142	39	38	44	25	10	25	2	0.37	0.63
367	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(5), CA1(2), CA13(1), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), HAL(4)	7629968	101	38	96	34	35	34	11	2	15	4	0.38	0.63
368	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18)	6411048	111	34	106	33	20	47	19	7	14	4	0.38	0.63
369	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(3), IL10(2), IL10RA(3), IL10RB(6), IL6(4), JAK1(16), STAT1(12), STAT3(8), STAT5A(2)	4429776	57	28	56	22	11	27	7	2	10	0	0.38	0.63
370	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CSK(1), GRB2(3), PRKCA(7), PTPRA(7), SRC(2)	3332376	41	25	40	18	8	11	10	4	8	0	0.38	0.63
371	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(3), CD3E(1), CD3G(1)	423088	5	5	5	1	0	2	1	0	2	0	0.38	0.63
372	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(4), ACAT2(4), HMGCL(2), OXCT1(8)	1210736	18	14	18	2	5	9	1	0	3	0	0.38	0.63
373	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(12), CALM2(3), CREB1(5), ELK1(2), FOS(2), GNAI1(4), GNAS(16), GNB1(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAF1(5), RPS6KA3(15), SYT1(4)	11877216	147	48	141	42	42	51	20	11	23	0	0.38	0.63
374	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAD(3), ALAS1(5), ALAS2(10), CPO(1), FECH(4), GATA1(5), HBB(2), HMBS(5), UROD(1), UROS(3)	2925656	39	21	38	13	6	20	6	2	5	0	0.39	0.63
375	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2E3(6), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(1), UBE2N(4), UBE3A(11)	3496056	47	26	47	16	9	18	11	1	8	0	0.39	0.63
376	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), PON1(11)	10547688	147	45	145	51	45	52	23	9	16	2	0.39	0.64
377	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), SELE(5), SELL(3), SELP(10)	6316312	77	35	74	26	22	30	8	4	11	2	0.39	0.64
378	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(4), TRAF6(3)	6570760	75	33	74	21	17	28	9	7	12	2	0.40	0.65
379	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(7), FMOD(2), KERA(8), LUM(11)	1357552	31	16	28	10	10	12	3	1	5	0	0.40	0.65
380	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(4), GLS(9), GLUD1(3), OAT(6)	1703760	23	16	21	8	2	11	5	1	4	0	0.40	0.65
381	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(5), ACTR3(1), ARHGAP1(2), ARHGAP4(8), ARHGAP5(18), ARHGAP6(11), ARHGEF1(9), ARHGEF11(18), ARHGEF5(4), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CFL1(1), DIAPH1(10), GSN(4), LIMK1(6), MYL2(1), MYLK(10), OPHN1(10), PFN1(1), PIP5K1A(6), PIP5K1B(3), PPP1R12B(11), ROCK1(15), SRC(2), TLN1(20), VCL(8)	16659400	194	57	191	66	67	71	22	14	16	4	0.41	0.66
382	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(11), ARRB2(3), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CLCA1(13), CLCA2(8), CLCA4(10), CNGA3(10), CNGA4(6), CNGB1(9), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(3), PDE1C(10), PRKACA(4), PRKACG(7), PRKG1(4), PRKG2(8), PRKX(2)	10849752	147	48	144	60	41	59	17	6	24	0	0.41	0.66
383	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(6), CYSLTR2(3), GPR161(3), GPR171(5), GPR18(1), GPR34(6), GPR39(8), GPR45(2), GPR65(8), GPR68(3), GPR75(8)	3622536	53	25	50	23	10	20	16	3	4	0	0.41	0.66
384	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(5), ACADM(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HIBCH(6), MLYCD(3), SMS(7), SRM(1), UPB1(8)	9586936	116	43	113	38	36	34	20	11	15	0	0.41	0.66
385	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(21), ABCA10(20), ABCA12(37), ABCA13(57), ABCA3(9), ABCA4(23), ABCA5(22), ABCA6(15), ABCA8(23), ABCA9(22), ABCB1(26), ABCB10(8), ABCB11(13), ABCB4(24), ABCB5(22), ABCB6(7), ABCB7(15), ABCB8(3), ABCB9(7), ABCC1(12), ABCC10(7), ABCC11(21), ABCC12(18), ABCC2(23), ABCC3(8), ABCC4(6), ABCC5(7), ABCC6(13), ABCC8(17), ABCC9(22), ABCD1(11), ABCD2(7), ABCD3(7), ABCD4(2), ABCG1(6), ABCG2(8), ABCG4(6), ABCG5(2), ABCG8(7), CFTR(12), TAP1(6)	40677456	602	95	581	159	150	243	77	37	82	13	0.41	0.66
386	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(16), JAK2(14), JAK3(5), PIAS1(3), PIAS3(7), PTPRU(12), REG1A(2), SOAT1(7)	5002904	67	29	66	18	13	28	9	3	10	4	0.42	0.67
387	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCS(4), UPB1(8)	4731344	79	29	78	13	24	25	14	5	11	0	0.42	0.67
388	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(5), CA1(2), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUL(6), HAL(4)	6862160	94	36	89	26	33	30	10	2	15	4	0.42	0.67
389	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(4), ALDOB(6), ALDOC(3), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GAPDHS(8), GCK(3), GOT1(5), GOT2(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(2), MDH2(4), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PKLR(5), PKM2(4), TNFAIP1(1)	14394664	170	53	168	62	49	66	20	13	22	0	0.43	0.68
390	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(27), ACACB(25), ACAT1(4), ACAT2(4), ACOT12(9), ACSS1(3), ACSS2(7), ACYP1(2), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PCK2(7), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4)	16478856	196	59	189	70	55	76	22	9	32	2	0.43	0.68
391	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), CDC42(4), CFL1(1), CFL2(7), FLNA(27), FLNC(27), FSCN1(2), FSCN3(4), GDI1(4), GDI2(1), LIMK1(6), MYH2(31), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PFN1(1), PFN2(1), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), VASP(1), WASF1(3), WASL(7)	16606328	211	59	209	62	66	84	21	9	29	2	0.43	0.68
392	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), ESRRA(2), HDAC5(10), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), SLC2A4(5), SYT1(4), YWHAH(2)	7029312	76	34	76	28	16	34	11	2	13	0	0.43	0.68
393	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(10), ACO2(5), ACSS1(3), ACSS2(7), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SUCLA2(5)	4867744	57	30	56	29	16	22	4	7	8	0	0.43	0.68
394	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(36), ASAH1(6), CASP3(3), CERK(6), CREB1(5), CREB5(3), CXCL2(2), DAG1(4), EPHB2(8), FOS(2), ITPKB(7), JUN(1), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4)	8730096	111	39	110	36	29	40	8	6	22	6	0.44	0.68
395	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL16(12), IL18(1), IL2(2), IL5(1), IL6(4), IL8(3), LTA(2)	3729672	42	25	41	13	9	19	6	2	6	0	0.44	0.68
396	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(5), ADCY9(17), ARF1(3), ARF3(2), ARF4(2), ARF5(4), ARF6(2), ARL4D(1), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ERO1L(5), GNAS(16), PDIA4(3), PLCG1(8), PLCG2(23), PRKCA(7), SEC61A1(2), SEC61A2(3), SEC61B(1), SEC61G(3), TRIM23(11)	13089440	197	52	191	47	53	87	19	10	26	2	0.44	0.68
397	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(6), CBS(9), CTH(4), MUT(6)	1639032	27	17	26	5	8	12	3	1	3	0	0.44	0.68
398	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPS(9), CDS1(4), CHAT(1), CHKA(7), CPT1B(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), ETNK1(8), GNPAT(6), GPD1(2), GPD2(3), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(4), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB2(7), PLCG1(8), PLCG2(23), PPAP2A(4), PPAP2B(2)	16781416	200	59	198	63	57	77	29	14	21	2	0.44	0.68
399	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(4), GLB1(4), HEXA(1), HEXB(3), LCT(24), SLC33A1(6), ST3GAL1(1), ST3GAL2(3), ST3GAL5(2), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5)	5898432	73	32	71	29	22	29	7	6	9	0	0.45	0.69
400	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), CAPN1(2), CAPNS1(1), CAPNS2(3), ITGA1(13), ITGB1(5), ITGB3(10), PTK2(8), PXN(4), RAC1(1), SPTAN1(23), SRC(2), TLN1(20)	10313080	115	45	114	49	43	42	11	4	15	0	0.45	0.69
401	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(31), RANGAP1(3)	2990880	35	21	35	5	8	11	7	2	7	0	0.45	0.69
402	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), AFMID(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(5), CYP1B1(1), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADH(1), HADHA(5), HEMK1(1), HSD17B10(2), HSD17B4(8), INMT(2), KMO(7), KYNU(3), LCMT1(2), LCMT2(8), LNX1(7), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NFX1(8), OGDH(9), OGDHL(15), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), TDO2(2), TPH1(9), TPH2(4), WARS(5), WARS2(2), WBSCR22(5)	21709920	276	66	266	77	66	112	41	21	34	2	0.45	0.69
403	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(9), FOS(2), GRB2(3), IL3RA(8), JAK2(14), MAP2K1(2), MAPK3(3), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	6209176	66	32	64	18	16	28	10	5	3	4	0.46	0.70
404	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(5), SNCA(2), SNCAIP(8), UBE2E2(2), UBE2F(1), UBE2G1(2), UBE2L3(2), UBE2L6(1)	2247376	30	19	30	11	9	12	3	4	2	0	0.46	0.70
405	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGK(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CEL(5), DAK(4), DGAT2(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), GK(13), GK2(18), GLA(2), GLB1(4), GPAM(6), LCT(24), LIPA(5), LIPC(5), LIPF(6), LIPG(4), LPL(9), MGLL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PNPLA3(6), PPAP2A(4), PPAP2B(2)	20289624	281	64	275	79	80	111	39	22	29	0	0.46	0.70
406	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2)	1543304	19	15	19	4	4	9	2	0	4	0	0.46	0.70
407	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4)	2091384	32	19	32	5	9	10	8	0	5	0	0.47	0.71
408	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(14), EPHB1(19), FYN(6), ITGA1(13), ITGB1(5), L1CAM(13), LYN(6), RAP1B(2), SELP(10)	5883056	91	33	89	28	22	44	10	4	11	0	0.47	0.71
409	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HSD3B7(3), PON1(11), PON2(6), PON3(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	3188536	48	26	46	8	15	16	9	2	6	0	0.47	0.71
410	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(6), AADAC(4), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ACSM1(8), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH7A1(2), ALDH9A1(1), BDH1(3), BDH2(4), DDHD1(10), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADH(1), HADHA(5), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), HSD3B7(3), ILVBL(7), L2HGDH(3), OXCT1(8), OXCT2(2), PDHA1(4), PDHA2(8), PDHB(3), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	14378792	180	52	173	48	45	72	26	15	20	2	0.47	0.71
411	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), ESCO1(8), ESCO2(5), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), NAT6(1), PNPLA3(6), PRDX6(2), SH3GLB1(6), TAT(5), TPO(11)	12331800	131	46	125	47	35	43	21	9	23	0	0.47	0.71
412	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(8), BCMO1(2), RDH5(3)	1415336	19	13	19	11	7	6	1	1	4	0	0.48	0.71
413	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(2), EPO(1), EPOR(3), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PLCG1(8), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	7731648	78	36	74	18	22	27	13	6	6	4	0.48	0.71
414	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(6), IFNAR2(6), IFNB1(2), JAK1(16), STAT1(12), STAT2(5), TYK2(4)	3963784	51	25	49	18	11	16	11	5	8	0	0.48	0.71
415	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(3), CD3E(1), CD3G(1), CXCR3(5), ETV5(3), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), JAK2(14), JUN(1), MAP2K6(6), MAPK14(4), MAPK8(7), STAT4(6), TYK2(4)	6621848	92	34	91	25	16	28	16	12	16	4	0.48	0.71
416	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(3), ALDH18A1(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), GATM(4), GLUD1(3), OAT(6), ODC1(1), OTC(6), SMS(7)	5584216	72	31	70	25	18	31	9	3	7	4	0.48	0.71
417	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(7), ARSD(6), ARSE(5), CARM1(4), CYP11B1(4), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD17B1(3), HSD17B12(3), HSD17B2(2), HSD17B3(5), HSD17B7(3), HSD17B8(2), HSD3B1(1), HSD3B2(5), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), SULT2B1(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), WBSCR22(5)	17466640	264	56	251	72	74	100	34	19	35	2	0.48	0.71
418	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(14), BMPR1A(4), BMPR1B(6), BMPR2(9)	2225552	33	19	33	5	10	13	7	0	3	0	0.49	0.71
419	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	AANAT(2), ACHE(3), CHAT(1), DBH(7), DDC(9), GAD1(6), GAD2(10), HDC(6), MAOA(10), PAH(1), PNMT(1), TPH1(9)	4825336	65	29	64	16	14	19	17	1	12	2	0.49	0.71
420	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(2), DRD1(5), DRD2(6), GRM1(18), PLCB1(4), PPP1CA(3), PPP1R1B(2), PPP2CA(4), PPP3CA(2), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	5614224	68	31	67	28	19	29	8	2	10	0	0.49	0.71
421	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), IMPA2(5), PGM1(5), PGM3(4), TGDS(3)	3838296	45	25	45	23	12	15	8	4	6	0	0.49	0.72
422	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(5), AGXT(3), AGXT2(8), AKR1B10(3), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), BHMT(2), CBS(9), CHDH(2), CHKA(7), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), GNMT(2), HSD3B7(3), MAOA(10), MAOB(5), PEMT(1), PHGDH(5), PIPOX(2), PISD(2), PSAT1(3), PSPH(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SARDH(8), SARS(2), SARS2(3), SDS(1), SHMT1(4), SHMT2(2), TARS(5), TARS2(7)	15046904	181	51	176	67	51	71	30	9	20	0	0.49	0.72
423	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(9), F11(9), F12(2), F13B(13), F2(8), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), LPA(11), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5), SERPINF2(4), VWF(19)	12544832	221	49	209	62	62	84	40	9	26	0	0.49	0.72
424	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ACAA2(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(7), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), SOAT2(5), SRD5A1(4), SRD5A2(5)	8363552	120	38	116	30	39	40	19	7	15	0	0.49	0.72
425	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(1)	1899928	17	15	17	7	8	5	3	0	1	0	0.50	0.72
426	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	B3GALNT1(3), B3GALT1(9), B3GALT2(6), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT6(4), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GBGT1(5), GCNT2(10), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGX(2), PIGZ(4), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5), UGCG(4)	16131656	222	59	218	49	63	100	24	12	23	0	0.50	0.72
427	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(5), AGXT(3), AGXT2(8), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), ATP6V0C(1), BHMT(2), CBS(9), CHDH(2), CHKA(7), CPT1B(1), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), MAOA(10), MAOB(5), PEMT(1), PISD(2), PLCB2(7), PLCG1(8), PLCG2(23), PSPH(1), SARDH(8), SARS(2), SHMT1(4), SHMT2(2), TARS(5)	14641920	182	52	176	57	53	69	27	12	21	0	0.51	0.73
428	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(7), SUCLA2(5)	783184	12	9	11	2	2	9	0	0	1	0	0.51	0.73
429	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(3), FUT2(1), FUT3(7), FUT6(9), ST3GAL3(4)	1592160	24	16	24	9	2	18	2	1	1	0	0.51	0.74
430	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(1), B4GALT7(3), CHPF(3), CHST11(7), CHST12(3), CHST14(2), CHST3(3), CHST7(4), DSE(14), UST(3), XYLT1(10), XYLT2(3)	4813184	61	29	60	28	14	28	14	2	3	0	0.52	0.74
431	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(5), ALAS2(10), CPOX(4), FECH(4), HMBS(5), UROD(1), UROS(3)	2826456	35	18	34	9	5	18	6	2	4	0	0.52	0.74
432	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), CEL(5), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), GK(13), GLA(2), GLB1(4), LCT(24), LIPC(5), LIPF(6), LIPG(4), LPL(9), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PPAP2A(4), PPAP2B(2)	16470920	222	57	220	63	61	86	33	18	24	0	0.52	0.74
433	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ALDH4A1(1), ARG1(4), ARG2(3), ASL(2), ASS1(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), EPRS(7), GATM(4), GLUD1(3), GLUD2(6), GOT1(5), GOT2(3), LAP3(6), NOS1(14), NOS3(6), OAT(6), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), PARS2(3), PYCR2(1), PYCRL(1), RARS(9), RARS2(6)	11903008	142	48	139	60	34	64	22	7	11	4	0.52	0.74
434	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL1(3), FOSL2(5), IFNAR1(6), IFNAR2(6), IFNB1(2), MAPK8(7), NFKB1(7), RELA(4), TNFRSF11A(4), TNFSF11(5), TRAF6(3)	4038928	54	27	52	11	14	18	14	2	6	0	0.52	0.74
435	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18), MASP1(9), MASP2(5), MBL2(3)	7723712	128	37	122	42	26	58	19	7	14	4	0.52	0.74
436	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(6), ARSE(5), ASAH1(6), B4GALT6(4), CERK(6), DEGS1(5), DEGS2(4), ENPP7(2), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SGMS1(2), SGMS2(3), SGPP1(2), SGPP2(3), SMPD1(10), SMPD2(4), SMPD3(4), SMPD4(7), SPHK1(2), SPHK2(1), SPTLC1(5), SPTLC2(4), UGCG(4), UGT8(11)	11599208	155	47	152	46	48	66	11	10	20	0	0.53	0.74
437	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTR(7)	6094352	78	33	75	34	20	36	9	2	11	0	0.53	0.74
438	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(6), NTRK1(11), PIR(4), RAC1(1), WASF1(3), WASF2(3), WASF3(7), WASL(7)	5606536	65	31	65	23	23	28	6	2	6	0	0.53	0.74
439	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(5), MDH1(2), ME1(7), PC(9), PDHA1(4), SLC25A1(2), SLC25A11(2)	3281536	37	21	37	20	7	17	6	2	5	0	0.53	0.75
440	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18)	6123864	48	32	47	13	13	22	8	2	3	0	0.53	0.75
441	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(3), GTF2F1(5), HDAC3(8), NCOA1(15), NCOA2(13), NCOA3(8), NCOR2(16), POLR2A(17), RARA(1), RXRA(1), TBP(3)	8342472	104	38	101	40	23	46	20	5	10	0	0.53	0.75
442	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIK(1), BIRC2(10), BIRC3(2), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), DFFB(3), DIABLO(2)	4777720	66	26	64	20	16	17	14	2	17	0	0.54	0.75
443	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CSF3(1), EPO(1), FLT3(7), IGF1(2), IL6(4), KITLG(2), TGFB1(2), TGFB2(5), TGFB3(8)	2993360	32	20	32	7	7	17	4	0	4	0	0.54	0.75
444	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(7), ACADM(4), ACADS(4), ACAT1(4), ECHS1(2), HADHA(5)	1881576	26	15	26	10	3	12	4	4	3	0	0.55	0.76
445	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(3), CAPN2(5), CAPNS1(1), CAPNS2(3), EP300(23), HDAC1(3), HDAC2(4), MEF2D(5), NFATC2(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SYT1(4)	8418856	89	35	88	29	19	28	15	6	19	2	0.55	0.76
446	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(12), CAP1(7), CCNB1(7), CDC25C(5), GNAI1(4), GNAS(16), GNB1(1), MAPK1(2), MAPK3(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RPS6KA1(1), SRC(2)	6755272	84	36	81	22	18	39	12	3	12	0	0.55	0.76
447	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(4), AASS(6), KARS(3)	1715912	19	14	18	7	8	4	5	2	0	0	0.55	0.76
448	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(4), CBS(9), CTH(4), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(8), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), METTL2B(3), METTL6(3), PAPSS1(5), PAPSS2(5), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SCLY(2), SEPHS1(10), SEPHS2(3), WBSCR22(5)	8667104	124	38	119	37	37	49	15	5	18	0	0.56	0.76
449	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C8B(3), C9(18), MASP1(9)	7634432	123	36	116	39	23	56	19	7	14	4	0.56	0.77
450	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(4), GPLD1(7), PGAP1(8), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGW(7), PIGX(2), PIGZ(4)	8335280	100	41	99	18	27	41	14	6	12	0	0.56	0.77
451	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(7), MAP3K14(4), MAPK14(4), MAPK8(7), NFKB1(7), RELA(4), TNFRSF13B(1), TNFSF13B(2), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3)	5151456	51	28	50	16	9	21	9	3	9	0	0.57	0.78
452	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(4), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(3), HMGCS2(6), OXCT1(8), OXCT2(2)	2530096	36	21	36	6	13	15	2	2	4	0	0.57	0.78
453	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), PGM1(5), PGM3(4), TGDS(3)	3653784	40	23	40	23	12	11	8	4	5	0	0.58	0.78
454	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(16), JAK2(14), JAK3(5), MAPK1(2), MAPK3(3), STAT3(8), TYK2(4)	4198888	52	25	52	23	5	21	10	3	9	4	0.58	0.78
455	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GCNT2(10), ST3GAL6(6), ST8SIA1(1)	5107064	72	28	71	14	17	37	6	4	8	0	0.58	0.78
456	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), HSD3B7(3), NSD1(25), OGDH(9), OGDHL(15), PIPOX(2), PLOD1(3), PLOD2(13), PLOD3(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SETD1A(9), SETD7(5), SETDB1(14), SHMT1(4), SHMT2(2), SPCS3(2), SUV39H1(7), SUV39H2(2), TMLHE(4)	20225392	216	62	210	66	55	87	39	14	19	2	0.58	0.78
457	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB1A(3), RAB27A(2), RAB3A(2), RAB4A(4), RAB5A(1), RAB6A(1), RAB9A(6)	1595136	23	14	22	7	9	8	3	0	3	0	0.59	0.79
458	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(12), CREM(3), FHL5(4), FSHR(14), GNAS(16), XPO1(12)	3251280	61	24	57	14	20	27	9	1	4	0	0.59	0.79
459	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(2), CHIT1(4), CMAS(4), CTBS(3), CYB5R1(3), CYB5R3(5), GFPT1(8), GFPT2(10), GNE(8), GNPDA1(1), GNPDA2(6), GNPNAT1(1), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NAGK(1), NANS(4), NPL(5), PGM3(4), PHPT1(1), RENBP(3), UAP1(5)	10217848	133	44	131	47	31	49	22	7	24	0	0.59	0.79
460	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), F10(9), F11(9), F12(2), F2(8), F2R(6), F5(36), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), PROC(3), PROS1(1), SERPINC1(5), SERPING1(6)	16154472	278	56	267	64	83	100	43	15	32	5	0.59	0.80
461	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(9), B3GALT2(6), B3GALT5(4), B3GNT5(4), FUT1(3), FUT2(1), FUT3(7), ST3GAL3(4), ST3GAL4(3)	2672200	41	21	39	11	9	20	5	2	5	0	0.60	0.80
462	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), GSR(4), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), TXNDC12(4)	7264912	96	38	93	34	28	33	14	11	8	2	0.60	0.80
463	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(3), CDKN1A(1), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SP1(6), SP3(8), SYT1(4)	7233416	73	33	70	29	21	24	12	5	11	0	0.60	0.80
464	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(3), CASP7(4), DFFB(3), GZMB(2), HMGB1(2), HMGB2(4), TOP2A(11), TOP2B(19)	3651800	48	24	47	13	4	15	11	5	13	0	0.60	0.80
465	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(5), ACY1(3), ADC(5), AGMAT(3), ALDH18A1(9), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), ASS1(2), CPS1(19), GATM(4), MAOA(10), MAOB(5), ODC1(1), OTC(6), SAT1(5), SMS(7), SRM(1)	10386984	124	43	120	51	37	47	14	8	14	4	0.61	0.80
466	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(3), HDAC9(14), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), YWHAH(2)	2920944	41	21	39	13	5	22	6	2	6	0	0.61	0.80
467	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(1), AKR1B10(3), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), FUK(4), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), HSD3B7(3), KHK(1), LHPP(2), MPI(3), MTMR1(13), MTMR2(2), MTMR6(7), PFKFB1(7), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PGM2(4), PHPT1(1), PMM2(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SORD(3), TSTA3(3)	12474400	143	50	139	55	32	57	21	9	24	0	0.61	0.81
468	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAA2(2), ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(3), AKR1C4(5), AKR1D1(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), HSD3B7(3), LIPA(5), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(7), SOAT2(5), SRD5A1(4), SRD5A2(5)	11266888	151	44	147	37	49	53	23	7	17	2	0.61	0.81
469	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	549816	8	7	8	1	1	4	2	0	1	0	0.62	0.81
470	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(5), FARSB(5), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4), YARS2(2)	3187544	32	21	32	9	10	11	6	5	0	0	0.62	0.81
471	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(5), FOS(2), FYN(6), JUN(1), MAPK14(4), THBS1(9)	2701216	30	19	30	7	8	11	2	4	5	0	0.62	0.81
472	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFAT5(10), PDE6A(9), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(12)	12596168	141	47	139	54	40	55	18	3	23	2	0.62	0.81
473	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(3), ANKRD1(3), ATF3(3), CYR61(2), DUSP14(3), EIF4E(2), HBEGF(2), IFNG(5), IFRD1(6), IL18(1), IL1R1(4), MYOG(1), NR4A3(8), WDR1(9)	3764144	52	24	52	16	16	15	11	2	8	0	0.62	0.81
474	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), NAGLU(2), SPAM1(11)	7048656	78	34	78	40	18	36	9	7	8	0	0.63	0.81
475	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), HMGCS1(3), IDI1(3), MVD(3), MVK(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4)	4303792	50	25	49	21	18	14	8	3	7	0	0.63	0.81
476	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(6), AOC3(9), CES1(11), ESD(1)	2289040	32	18	29	13	10	8	8	3	3	0	0.63	0.81
477	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PCYT1A(1), PCYT1B(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5)	4952808	59	26	57	17	17	20	6	3	13	0	0.63	0.82
478	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(3), CD3E(1), CD3G(1), CD4(6), FYN(6), LCK(3), PTPRC(11), ZAP70(6)	3304600	37	21	37	8	6	16	4	1	10	0	0.64	0.82
479	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(27), ACAT1(4), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4)	12873680	148	49	146	54	39	56	18	8	27	0	0.64	0.82
480	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(7), CDC25B(2), CDK7(4), CDKN1A(1), CHEK1(2), NEK1(17), WEE1(1)	2677656	34	20	32	3	11	12	4	1	6	0	0.64	0.82
481	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(9), CTH(4), GGT1(5), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), PAPSS1(5), PAPSS2(5), SCLY(2), SEPHS1(10)	4285936	67	26	64	24	21	29	9	2	6	0	0.64	0.82
482	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(2), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTAP(2), MTR(7), SRM(1), TAT(5)	7179600	88	35	85	42	22	41	11	3	11	0	0.64	0.82
483	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(6), CARS(6), DARS(4), EPRS(7), FARS2(2), GARS(6), HARS(3), IARS(7), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), QARS(4), RARS(9), SARS(2), TARS(5), WARS(5), WARS2(2), YARS(4)	11726680	115	43	115	48	26	53	21	5	10	0	0.64	0.82
484	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(7), CCNH(3), CDC25A(7), CDC25B(2), CDC25C(5), CDK7(4), SHH(4), XPO1(12)	3142656	44	22	42	9	10	16	10	2	6	0	0.65	0.82
485	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(10), ACE2(17), AGT(7), AGTR1(1), AGTR2(7), ANPEP(11), CMA1(1), CPA3(4), CTSA(8), CTSG(3), ENPEP(12), LNPEP(6), MAS1(1), MME(6), NLN(4), REN(1)	7290704	99	35	95	33	31	35	16	6	9	2	0.65	0.82
486	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(10), ACO2(5), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2)	4654216	56	29	55	22	21	20	7	5	3	0	0.65	0.82
487	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), BCR(4), CAPN1(2), CAPNS1(1), CAPNS2(3), CRKL(4), CSK(1), FYN(6), GRB2(3), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(11), PTK2(8), PXN(4), RAF1(5), RAP1A(3), ROCK1(15), SHC1(5), SOS1(10), SRC(2), TLN1(20), VCL(8), ZYX(11)	16047832	182	55	178	48	60	69	24	7	20	2	0.65	0.82
488	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(5), ACY3(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), AMDHD1(10), AOC2(6), AOC3(9), ASPA(4), CARM1(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HARS2(6), HDC(6), HEMK1(1), HNMT(4), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(6), UROC1(8), WBSCR22(5)	13852536	177	49	171	53	53	58	26	11	29	0	0.65	0.82
489	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(3), IL8(3), NFKB1(7), NOX1(10), RELA(4), SOD1(2), XDH(9)	3707352	42	22	42	11	12	14	8	2	6	0	0.65	0.82
490	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), CHST1(8), CHST2(1), CHST4(1), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3)	3989576	56	27	52	22	18	26	8	1	3	0	0.66	0.82
491	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(7)	2992864	34	20	34	10	10	15	2	0	7	0	0.66	0.82
492	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), GCK(3), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), KHK(1), MPI(3), PFKFB1(7), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PMM2(6), SORD(3)	8502432	93	39	92	41	22	39	13	7	12	0	0.66	0.83
493	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PDXK(3), PNPO(1), PSAT1(3)	1675736	21	15	21	11	6	8	3	1	3	0	0.67	0.83
494	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(3), ENO3(3), FARS2(2), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4)	3036264	30	18	30	8	5	13	5	5	2	0	0.67	0.83
495	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), LTB4R(2), P2RY1(2), P2RY2(3), P2RY6(3)	2076504	21	17	21	11	6	7	6	2	0	0	0.67	0.84
496	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(6), AARS2(5), CARS(6), DARS(4), DARS2(6), EARS2(3), EPRS(7), FARS2(2), FARSA(5), FARSB(5), GARS(6), HARS(3), HARS2(6), IARS(7), IARS2(13), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), NARS2(6), PARS2(3), QARS(4), RARS(9), RARS2(6), SARS(2), SARS2(3), TARS(5), TARS2(7), VARS(4), WARS(5), WARS2(2), YARS(4), YARS2(2)	19823384	189	61	188	71	48	86	31	9	15	0	0.67	0.84
497	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), GLCE(2), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), NDST1(11), NDST2(4), NDST3(12), NDST4(11)	7166208	112	37	110	32	26	50	17	4	13	2	0.68	0.84
498	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(5), FH(8), IDH2(4), MDH1(2), OGDH(9), SDHA(10), SUCLA2(5)	3451416	48	23	48	19	12	25	5	4	2	0	0.68	0.84
499	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(18), ARHGEF1(9), GNA12(7), GNA13(7), GNB1(1), MYL2(1), MYLK(10), PLCB1(4), PPP1R12B(11), PRKCA(7), ROCK1(15)	7568216	90	34	88	30	30	30	12	6	6	6	0.69	0.85
500	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(43), MAP2(21), PPP1CA(3), PPP2CA(4), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3), PRKCE(7)	6711624	93	33	91	21	17	35	17	3	18	3	0.69	0.85
501	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	ASAH1(6), DAG1(4), ITPKB(7)	1915800	17	16	17	11	6	7	1	0	3	0	0.70	0.85
502	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(3), IL1B(2), MST1(3), MST1R(9)	2187608	17	13	16	8	7	4	1	1	4	0	0.70	0.86
503	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), KARS(3)	2547456	26	18	25	12	10	5	7	2	2	0	0.70	0.86
504	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), IDI1(3), MVD(3), MVK(3), NQO1(3), NQO2(4), PMVK(2), SC5DL(2), SQLE(4), VKORC1(1)	3534000	43	22	41	19	13	16	6	3	5	0	0.70	0.86
505	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CAMKK1(9), CAMKK2(6), CREB1(5), SYT1(4)	3969488	49	26	48	11	11	23	5	2	8	0	0.71	0.86
506	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(6), MBTPS1(9), MBTPS2(8), SCAP(10), SREBF1(2), SREBF2(8)	3681808	46	24	45	17	11	22	5	2	6	0	0.72	0.87
507	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(3), UGDH(2), UGP2(5), UXS1(5)	1864216	17	14	16	7	5	6	3	1	2	0	0.72	0.87
508	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(4), ERCC3(8), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2H1(6), ILK(4), POLR1A(11), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3B(6), POLR3D(2), POLR3E(3), POLR3H(3), TAF5(5), TAF6(6), TAF7(3), TAF9(2), TBP(3)	12831520	128	45	126	45	29	55	16	11	17	0	0.72	0.87
509	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5), CYP2C9(4)	748464	9	7	9	3	4	4	0	0	1	0	0.72	0.88
510	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	268832	3	2	3	0	1	2	0	0	0	0	0.73	0.88
511	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(13), HSD17B1(3), HSD17B2(2), HSD17B3(5), HSD17B4(8), HSD17B7(3), HSD3B1(1), HSD3B2(5)	2945000	41	22	38	17	12	18	3	1	7	0	0.73	0.88
512	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(3), APAF1(11), CASP3(3), CASP9(2), CYCS(2), DAXX(6), FAS(6), FASLG(5), HSPB2(1), MAPKAPK2(4), MAPKAPK3(2)	3952376	45	24	45	11	13	15	8	3	6	0	0.73	0.88
513	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB10(3), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMB8(2), PSMB9(1)	3166216	34	20	32	11	4	14	5	2	9	0	0.74	0.89
514	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMD14(2), RPN1(2), RPN2(5), UBE2A(3), UBE3A(11)	4810456	51	25	49	17	7	22	7	3	12	0	0.75	0.89
515	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CAT(3), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADHA(5), KMO(7), KYNU(3), MAOA(10), MAOB(5), SDS(1), TDO2(2), TPH1(9), WARS(5), WARS2(2)	20085024	266	60	262	87	76	96	40	18	32	4	0.75	0.90
516	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(4), ALDOB(6), ALDOC(3), DERA(8), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TALDO1(3), TKT(4), TKTL1(7), TKTL2(12)	8161928	103	39	98	35	28	43	14	5	13	0	0.75	0.90
517	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(2), ATG5(3), ATG7(2), GABARAP(1), GABARAPL1(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNG(5), PIK3C3(9), PIK3R4(17), PRKAA1(5), PRKAA2(7), ULK2(7), ULK3(5)	7000048	88	32	88	24	27	35	12	4	10	0	0.75	0.90
518	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(4), COQ5(3), COQ6(3), COQ7(3), NDUFA13(1)	1462208	14	12	14	5	2	7	3	0	2	0	0.76	0.90
519	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(2), SNAP23(1), SNAP25(7), SNAP29(1), STX10(1), STX11(3), STX12(3), STX16(1), STX17(1), STX18(1), STX3(6), STX4(4), STX5(5), STX6(3), STX7(4), STX8(2), TSNARE1(3), USE1(4), VAMP1(1), VAMP4(1), VTI1B(5), YKT6(4)	5946048	65	31	62	24	15	30	8	3	9	0	0.76	0.90
520	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NFS1(2), PHPT1(1), TPK1(2)	2294000	29	16	28	12	5	9	6	0	9	0	0.76	0.90
521	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8), MECR(6), PPT1(2), PPT2(1)	3002784	32	20	31	7	6	11	7	7	1	0	0.76	0.90
522	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RELA(4)	3000800	24	18	24	16	2	10	6	3	3	0	0.76	0.90
523	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(9), PER2(6), PER3(10)	5806176	59	29	56	16	21	21	7	2	8	0	0.76	0.90
524	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(6), BFAR(6), BRAF(9), CREB1(5), CREB5(3), MAPK1(2), RAF1(5), SNX13(11), SRC(2), TERF2IP(2)	4115560	51	23	51	10	9	19	11	3	9	0	0.76	0.90
525	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5)	5201304	68	26	66	14	18	25	7	3	15	0	0.76	0.90
526	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(7), AMT(2), ATIC(6), ATP6V0C(1), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2)	6538024	60	31	58	22	14	30	6	3	7	0	0.77	0.90
527	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), PER1(9)	2852744	33	19	32	9	13	10	5	1	4	0	0.77	0.90
528	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(8), F2R(6), GNAI1(4), GNB1(1), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(9), PLCB1(4), PRKCA(7), PTGS1(5), PTK2(8), RAF1(5), SRC(2), SYK(3), TBXAS1(4)	8641312	91	36	91	32	23	31	19	6	12	0	0.77	0.90
529	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(8), AZIN1(3), CBX3(3), CLOCK(6), CRY1(5), CRY2(2), DNAJA1(2), EIF4G2(6), ETV6(5), GFRA1(6), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(7), IDI1(3), KLF9(3), MYF6(5), NCKAP1(6), NCOA4(6), NR1D2(1), PER1(9), PER2(6), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), SF3A3(5), SUMO3(2), TOB1(2), UGP2(5), VAPA(5), ZFR(9)	12857064	136	44	132	36	40	53	19	9	15	0	0.78	0.91
530	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(6), RXRA(1)	1914808	22	16	22	5	3	12	4	0	3	0	0.78	0.91
531	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(4), ACOX1(3), ACOX3(5), ELOVL2(6), ELOVL5(2), ELOVL6(2), FADS1(4), FADS2(1), HADHA(5), HSD17B12(3), PECR(4), SCD(6)	3856400	45	22	45	12	10	20	8	3	4	0	0.79	0.91
532	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(10), CD44(4), CSF1(3), FCGR3A(1), IL1B(2), IL6R(7), SELL(3), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(6), TNFSF8(1)	4773008	50	26	47	18	11	19	9	3	8	0	0.79	0.91
533	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(5), AGMAT(3), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), GATM(4), GLUD1(3), GOT1(5), GOT2(3), MAOA(10), MAOB(5), NOS1(14), NOS3(6), OAT(6), ODC1(1), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), RARS(9), SMS(7)	14916952	183	50	178	67	49	76	21	14	19	4	0.79	0.91
534	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3)	2704192	41	20	37	11	14	18	7	0	2	0	0.79	0.91
535	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), SLC23A1(6), SLC23A2(4), SLC2A1(2), SLC2A3(8)	9232792	123	39	120	36	36	49	12	7	14	5	0.79	0.91
536	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(6), IDI1(3), SQLE(4)	1173288	14	10	14	2	5	4	3	1	1	0	0.80	0.92
537	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CMBL(3), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), PON1(11), PON2(6), PON3(1)	6301928	84	31	82	26	20	26	18	7	13	0	0.80	0.92
538	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(6), SNAP25(7)	1192384	16	13	15	4	7	5	3	0	1	0	0.81	0.92
539	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(3), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2)	2042776	21	15	21	9	4	11	2	0	4	0	0.81	0.92
540	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ADCY4(7), ADCY6(10), ADCY8(15), CACNA1A(15), GNAS(16), GNAT3(6), GNB1(1), GNG13(2), GNG3(2), GRM4(12), ITPR3(15), KCNB1(11), PDE1A(10), PLCB2(7), PRKACA(4), PRKACG(7), PRKX(2), SCNN1A(2), SCNN1B(4), SCNN1G(8), TAS1R1(7), TAS1R2(8), TAS2R1(4), TAS2R10(5), TAS2R13(2), TAS2R14(5), TAS2R16(2), TAS2R3(2), TAS2R38(3), TAS2R39(7), TAS2R4(2), TAS2R40(4), TAS2R41(2), TAS2R42(3), TAS2R46(2), TAS2R5(3), TAS2R50(2), TAS2R60(5), TAS2R7(2), TAS2R8(5)	19686240	231	54	225	88	67	97	30	12	25	0	0.81	0.92
541	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(7), AGTR1(1), AGTR2(7), BDKRB2(7), KNG1(7), NOS3(6), REN(1)	3176880	46	21	43	11	16	22	3	2	3	0	0.81	0.92
542	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(3), UGDH(2), UXS1(5)	1475600	12	11	12	7	3	4	3	1	1	0	0.81	0.92
543	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(17), AGT(7), AGTR1(1), AGTR2(7), CMA1(1), COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), REN(1)	9366464	137	40	133	31	43	56	12	7	14	5	0.82	0.93
544	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), PGD(2)	6509008	77	33	75	27	22	28	10	11	4	2	0.82	0.93
545	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(11), BAD(2), BAK1(3), BAX(3), BCL10(2), BCL2L1(3), BCL2L11(5), BID(2), CASP8AP2(3), CASP9(2), CES1(11)	4133664	47	23	46	8	9	16	14	1	7	0	0.82	0.93
546	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(11), EIF2AK4(5), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF5(2), GSK3B(8), PPP1CA(3)	4211288	43	25	42	10	11	19	5	2	6	0	0.83	0.93
547	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(7), APOBEC2(3), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(4), APOBEC3G(2), APOBEC4(4)	2687080	36	20	36	9	9	19	6	1	1	0	0.83	0.93
548	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	17239968	193	54	191	67	54	73	25	12	29	0	0.83	0.93
549	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	17239968	193	54	191	67	54	73	25	12	29	0	0.83	0.93
550	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(15), AMY2A(4), AMY2B(9), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHX58(5), ENPP1(8), ENPP3(14), ENTPD7(6), ERCC2(1), ERCC3(8), G6PC(5), G6PC2(4), GAA(4), GANC(13), GBA(3), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), IFIH1(3), LYZL1(1), MGAM(36), NUDT5(1), NUDT8(1), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SI(43), SKIV2L2(15), SMARCA2(18), SMARCA5(14), TREH(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UXS1(5)	43804240	589	85	570	154	153	207	110	39	73	7	0.83	0.93
551	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAS(16), GNB1(1), LIMK1(6), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), NOX1(10), PIK3C2G(12), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2(8), RAF1(5), ROCK2(10)	9087960	103	37	100	30	29	36	19	7	12	0	0.84	0.93
552	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(4), CALCRL(7), CD97(7), CRHR1(2), CRHR2(1), ELTD1(10), EMR1(19), EMR2(3), GHRHR(1), GIPR(3), GLP1R(5), GLP2R(8), GPR64(8), LPHN1(11), LPHN2(19), LPHN3(14), SCTR(3), VIPR1(2)	9781120	132	39	127	49	30	65	12	8	15	2	0.84	0.93
553	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(3), CXCR3(5), EGF(17), EGFR(10), ITGA1(13), ITGB1(5), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTK2(8), PXN(4), TLN1(20)	11861344	133	43	131	41	33	57	20	5	18	0	0.84	0.93
554	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(7), AMT(2), ATIC(6), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2)	6685832	59	30	57	23	13	30	6	3	7	0	0.84	0.93
555	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(3), ACSS2(7), ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), G6PC2(4), GAPDH(2), GAPDHS(8), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	19935232	215	56	212	76	64	78	29	15	29	0	0.84	0.93
556	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(11), CD2(4), CD33(6), CD5(5), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL5(1), ITGAX(7), TLR2(11), TLR4(13), TLR7(12), TLR9(5)	6853480	91	32	89	32	27	36	13	4	9	2	0.86	0.95
557	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CYP2C19(5), CYP2C9(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2)	11057576	79	36	78	29	25	28	10	6	10	0	0.86	0.96
558	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TAL1(1), TALDO1(3), TKT(4)	7175384	77	32	75	30	23	31	12	4	7	0	0.88	0.97
559	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), EPO(1), EPOR(3), GRIN1(3), HIF1A(12), JAK2(14), NFKB1(7), NFKBIA(2), RELA(4), SOD2(3)	4406960	52	22	52	17	11	17	12	3	5	4	0.88	0.97
560	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(5), FUT1(3), FUT2(1), FUT9(7), GCNT2(10), ST8SIA1(1)	2206208	27	17	27	6	7	14	4	2	0	0	0.88	0.97
561	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(5), ALOX15(7), ALOX15B(5), ALOX5(6), ALOX5AP(2), GGT1(5), LTA4H(4), PLA2G6(7), PTGDS(4), PTGES(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4)	4815168	68	26	67	16	20	31	9	3	5	0	0.89	0.97
562	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(3), ARFGAP1(2), ARFGAP3(3), ARFGEF2(24), CLTB(5), COPA(11), GBF1(10), GPLD1(7), KDELR1(1), KDELR3(3)	5715408	69	27	68	20	9	35	11	5	7	2	0.89	0.97
563	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1)	4213768	37	21	36	21	12	11	4	6	4	0	0.90	0.98
564	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(6), HLCS(3), SPCS3(2)	1099880	11	8	11	8	5	1	4	0	1	0	0.90	0.98
565	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), IDS(5), LCT(24), NAGLU(2)	4815168	48	25	48	23	11	22	6	5	4	0	0.90	0.98
566	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), DHFR(3), FPGS(3), GCH1(1), GGH(2)	2095352	19	15	19	9	4	10	2	2	1	0	0.91	0.98
567	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(16), JAK2(14), JAK3(5), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), TYK2(4)	6542736	70	29	69	37	10	34	10	3	9	4	0.91	0.98
568	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3)	597184	3	3	3	1	0	1	1	0	1	0	0.91	0.98
569	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1)	4730104	45	22	44	11	15	14	8	2	6	0	0.91	0.98
570	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(23), ABCG2(8), BCHE(13), CES1(11), CES2(2), CYP3A4(9), CYP3A5(4), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2)	8482344	116	34	112	33	28	46	21	11	8	2	0.91	0.98
571	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(14), CD38(5), ENPP1(8), ENPP3(14), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5E(5), NT5M(3)	5208248	73	27	71	12	15	32	16	7	3	0	0.92	0.98
572	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(4), RPE(2), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7)	5888760	62	27	60	14	24	21	8	4	5	0	0.92	0.98
573	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(4), ALDOB(6), ALDOC(3)	1435176	16	11	15	4	3	7	3	1	2	0	0.92	0.98
574	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRB(1), CP(11), CPOX(4), EPRS(7), FECH(4), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UROD(1), UROS(3)	9482032	99	35	96	31	30	42	14	6	7	0	0.92	0.98
575	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(3), GTF2A1L(2), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2F1(5), GTF2H1(6), GTF2H3(3), GTF2I(2), GTF2IRD1(6), STON1(1), TAF1(37), TAF10(1), TAF1L(30), TAF2(10), TAF4(8), TAF4B(4), TAF5(5), TAF5L(2), TAF6(6), TAF6L(4), TAF7(3), TAF7L(8), TAF9(2), TBPL1(4), TBPL2(4)	13185168	164	44	161	43	47	66	26	7	18	0	0.92	0.98
576	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAA2(2), ACAT1(4), ACAT2(4), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), SDS(1)	2957400	29	17	29	12	7	11	7	3	1	0	0.92	0.98
577	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), DAD1(1), DDOST(3), DHDDS(4), DOLPP1(1), DPAGT1(2), DPM1(1), FUT8(12), GANAB(8), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), RFT1(4), RPN1(2), RPN2(5), ST6GAL1(6), STT3B(3)	14900832	179	50	166	47	45	74	33	6	19	2	0.92	0.98
578	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), AOC2(6), AOC3(9), ASPA(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HDC(6), HNMT(4), MAOA(10), MAOB(5), PRPS1(3), PRPS2(6)	8900720	108	32	104	37	31	35	15	9	18	0	0.92	0.98
579	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3)	3696192	50	21	49	9	9	21	6	4	10	0	0.92	0.98
580	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(4), ACAT2(4), ACYP1(2), ECHS1(2), EHHADH(4), GCDH(5), HADHA(5), SDHB(1), SDS(1)	2745856	28	17	28	14	5	13	5	3	2	0	0.93	0.98
581	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(2), GPD2(3), NDUFA1(1), SDHA(10), SDHB(1), SDHC(4), UQCRC1(2)	2417256	30	16	30	7	5	17	5	2	1	0	0.93	0.98
582	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(9), KHK(1), LCT(24), MPI(3), PGM1(5), PYGL(6), PYGM(4), TREH(2)	4851624	54	22	54	29	8	23	10	6	7	0	0.93	0.98
583	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), CDS1(4), CHAT(1), CHKA(7), CHPT1(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), ESCO1(8), ESCO2(5), ETNK1(8), ETNK2(1), GNPAT(6), GPAM(6), GPD1(2), GPD1L(3), GPD2(3), LCAT(2), LYPLA1(1), LYPLA2(4), NAT6(1), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PNPLA3(6), PPAP2A(4), PPAP2B(2), PTDSS1(5), SH3GLB1(6)	22378280	235	60	234	79	62	93	34	13	33	0	0.93	0.98
584	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(3), DPAGT1(2), DPM1(1), FUT8(12), MAN1A1(10), MAN1B1(3), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), RPN1(2), RPN2(5), ST6GAL1(6)	6804624	84	30	77	21	26	32	16	2	8	0	0.93	0.98
585	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1)	1679952	13	10	13	14	3	4	3	3	0	0	0.93	0.98
586	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(6), GGPS1(2), IDI1(3), IDI2(1), SQLE(4)	1573808	17	11	17	5	6	6	3	1	1	0	0.93	0.98
587	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(2), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(6), NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RAF1(5), RELA(4)	5586448	49	25	49	17	7	19	11	8	4	0	0.93	0.98
588	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1)	2784296	25	15	24	10	9	8	1	3	4	0	0.94	0.98
589	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1)	2784296	25	15	24	10	9	8	1	3	4	0	0.94	0.98
590	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(6), EGF(17), EGFR(10), GRB2(3), MET(9), PDGFRA(19), PRKCA(7), SH3GLB1(6), SH3GLB2(3), SH3KBP1(6), SRC(2)	7119584	96	31	93	35	21	37	20	5	11	2	0.94	0.98
591	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), CDK5R1(2), DPM2(2), EGR1(6), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), NGFR(3), RAF1(5)	2731968	28	18	28	11	7	13	6	1	1	0	0.94	0.98
592	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(7), CHST12(3), PAPSS1(5), PAPSS2(5), SULT1A1(4), SULT1A2(1), SULT1E1(9), SULT2A1(6), SULT2B1(2)	3294928	43	19	39	17	11	24	5	1	2	0	0.94	0.98
593	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMC2(2), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(1), PSMD2(6), PSMD6(1)	5803696	53	25	50	21	11	20	8	2	12	0	0.95	0.98
594	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(2), DAB1(4), FYN(6), LRP8(3), RELN(36), VLDLR(3)	5183200	55	25	53	19	17	19	10	2	5	2	0.95	0.98
595	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(3), SRP19(3), SRP54(7), SRP68(4), SRP72(6), SRP9(1), SRPR(9)	2741144	34	16	34	8	10	14	2	3	5	0	0.95	0.98
596	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(1), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), NTAN1(3), SIRT1(4), SIRT2(4), SIRT5(1), VNN2(8)	4042400	43	20	41	18	7	21	9	4	2	0	0.95	0.98
597	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(4), ACAT2(4), ACOT11(4), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), GCDH(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2)	9325296	72	34	72	24	17	29	12	4	10	0	0.95	0.98
598	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(4), RPE(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), XYLB(5)	9133840	125	33	118	26	42	48	19	7	9	0	0.96	0.99
599	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(3), AKR1C2(3), AKR1C3(2), AKR1C4(5), ALDH3A1(2), ALDH3B2(5), CYP1A1(9), CYP1A2(5), CYP1B1(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2F1(3), CYP2S1(6), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHDH(2), EPHX1(1), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), MGST1(4), MGST3(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3)	20205800	274	56	265	64	80	108	45	16	25	0	0.97	0.99
600	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(14), BST1(1), CD38(5), ENPP1(8), ENPP3(14), NADK(4), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT12(2)	7702136	99	31	96	27	23	40	21	11	4	0	0.97	0.99
601	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ATP6V0C(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADHA(5), PLOD1(3), PLOD2(13), PLOD3(6), SDS(1), SHMT1(4), SHMT2(2), TMLHE(4)	12466216	120	40	118	43	34	39	20	10	15	2	0.97	0.99
602	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(1), CHKA(7), PCYT1A(1), PDHA1(4), PDHA2(8), PEMT(1)	2469336	25	14	25	10	9	5	5	2	4	0	0.97	0.99
603	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(3), IARS(7), IARS2(13), ILVBL(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3), VARS(4)	6785032	77	27	75	18	15	37	7	6	12	0	0.97	0.99
604	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(1), NR1I3(5), PTGS1(5), PTGS2(6)	1944320	22	13	22	6	7	8	3	1	3	0	0.98	0.99
605	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(4), ABP1(5), AOC2(6), AOC3(9), CES1(11), DDHD1(10), ESCO1(8), ESCO2(5), LIPA(5), NAT6(1), PLA1A(3), PNPLA3(6), PPME1(1), PRDX6(2), SH3GLB1(6)	9327776	82	31	78	32	23	23	17	5	12	2	0.98	0.99
606	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(3), DHCR24(5), DHCR7(2), FDFT1(1), FDPS(6), GGCX(7), GGPS1(2), HMGCR(9), HSD17B7(3), IDI1(3), IDI2(1), MVD(3), MVK(3), NQO1(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4), TM7SF2(1), VKORC1(1)	6542488	78	24	77	40	28	29	10	4	7	0	0.98	0.99
607	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(5), ALAS2(10), BLVRB(1), COX10(1), COX15(3), CP(11), CPOX(4), EARS2(3), EPRS(7), FECH(4), FTH1(2), FTMT(5), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), MMAB(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UROD(1), UROS(3)	14519408	186	42	178	51	55	79	29	11	12	0	0.98	0.99
608	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(2), CCR3(4), IL5(1)	1124184	7	6	7	1	0	4	2	0	1	0	0.98	1.00
609	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(5), PAPSS2(5), SULT1A2(1), SULT1E1(9), SULT2A1(6)	2261760	27	13	24	10	6	15	3	1	2	0	0.99	1.00
610	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(16), EGF(17), EGFR(10), RAB5A(1), TF(12), TFRC(3)	4653968	59	22	57	15	13	24	10	2	10	0	0.99	1.00
611	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6)	9099864	84	28	84	18	22	31	15	0	14	2	0.99	1.00
612	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(3), B3GALT5(4), FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST8SIA1(1)	3688256	36	18	34	15	10	16	5	2	3	0	0.99	1.00
613	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6)	6008296	40	22	40	9	11	16	6	0	7	0	1.00	1.00
614	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), UGDH(2)	2853240	15	12	14	7	7	4	0	2	2	0	1.00	1.00
615	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST8SIA1(1)	3458360	32	16	32	13	9	14	7	2	0	0	1.00	1.00
616	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHFR(3), DHX58(5), ENTPD7(6), ERCC2(1), ERCC3(8), FPGS(3), GCH1(1), GGH(2), IFIH1(3), NUDT5(1), NUDT8(1), PTS(1), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SKIV2L2(15), SMARCA2(18), SMARCA5(14)	22054640	234	51	223	66	57	84	45	16	25	7	1.00	1.00
