Breast Invasive Carcinoma: PARADIGM pathway analysis of mRNA expression data
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 70 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
Signaling events regulated by Ret tyrosine kinase 115
Signaling events mediated by Stem cell factor receptor (c-Kit) 113
FOXM1 transcription factor network 92
Syndecan-1-mediated signaling events 91
IGF1 pathway 85
Wnt signaling 83
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 83
Endothelins 82
EGFR-dependent Endothelin signaling events 82
HIF-1-alpha transcription factor network 76
Results

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
Signaling events regulated by Ret tyrosine kinase 115 9443 82 -0.23 0.018 1000 -1000 -0.053 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 113 8848 78 -0.39 0.17 1000 -1000 -0.038 -1000
FOXM1 transcription factor network 92 4708 51 -0.43 0.024 1000 -1000 -0.11 -1000
Syndecan-1-mediated signaling events 91 3097 34 -0.19 0.018 1000 -1000 -0.014 -1000
IGF1 pathway 85 4876 57 -0.14 0.057 1000 -1000 -0.054 -1000
Wnt signaling 83 582 7 -0.13 -0.011 1000 -1000 -0.011 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 83 5658 68 -0.43 0.22 1000 -1000 -0.067 -1000
Endothelins 82 7915 96 -0.25 0.018 1000 -1000 -0.041 -1000
EGFR-dependent Endothelin signaling events 82 1742 21 -0.17 0.024 1000 -1000 -0.047 -1000
HIF-1-alpha transcription factor network 76 5835 76 -0.25 0.025 1000 -1000 -0.057 -1000
Fc-epsilon receptor I signaling in mast cells 76 7379 97 -0.15 0.038 1000 -1000 -0.051 -1000
Plasma membrane estrogen receptor signaling 74 6417 86 -0.2 0.19 1000 -1000 -0.057 -1000
FAS signaling pathway (CD95) 70 3295 47 -0.16 0.072 1000 -1000 -0.027 -1000
IL6-mediated signaling events 70 5301 75 -0.18 0.043 1000 -1000 -0.03 -1000
TCGA08_retinoblastoma 70 562 8 -0.052 0.026 1000 -1000 -0.004 -1000
IL4-mediated signaling events 68 6261 91 -0.52 0.39 1000 -1000 -0.11 -1000
IL27-mediated signaling events 67 3439 51 -0.27 0.17 1000 -1000 -0.045 -1000
Glucocorticoid receptor regulatory network 66 7604 114 -0.54 0.28 1000 -1000 -0.046 -1000
TCR signaling in naïve CD8+ T cells 66 6170 93 -0.13 0.07 1000 -1000 -0.045 -1000
IL12-mediated signaling events 62 5415 87 -0.3 0.029 1000 -1000 -0.083 -1000
Noncanonical Wnt signaling pathway 62 1636 26 -0.13 0.018 1000 -1000 -0.023 -1000
Osteopontin-mediated events 58 2234 38 -0.15 0.018 1000 -1000 -0.027 -1000
IL23-mediated signaling events 58 3489 60 -0.27 0.017 1000 -1000 -0.096 -1000
Arf6 signaling events 57 3584 62 -0.15 0.034 1000 -1000 -0.013 -1000
Thromboxane A2 receptor signaling 55 5871 105 -0.14 0.038 1000 -1000 -0.046 -1000
Nongenotropic Androgen signaling 54 2812 52 -0.13 0.064 1000 -1000 -0.034 -1000
PLK2 and PLK4 events 49 149 3 -0.049 0.008 1000 -1000 -0.004 -1000
Stabilization and expansion of the E-cadherin adherens junction 49 3674 74 -0.14 0.03 1000 -1000 -0.059 -1000
E-cadherin signaling events 49 249 5 -0.049 0.011 1000 -1000 -0.002 -1000
Syndecan-4-mediated signaling events 48 3265 67 -0.08 0.022 1000 -1000 -0.022 -1000
Signaling events mediated by the Hedgehog family 46 2434 52 -0.16 0.056 1000 -1000 -0.024 -1000
BMP receptor signaling 46 3778 81 -0.23 0.046 1000 -1000 -0.061 -1000
ErbB4 signaling events 44 3049 69 -0.17 0.097 1000 -1000 -0.064 -1000
IL2 signaling events mediated by PI3K 43 2540 58 -0.23 0.018 1000 -1000 -0.049 -1000
amb2 Integrin signaling 41 3427 82 -0.12 0.023 1000 -1000 -0.043 -1000
Ephrin B reverse signaling 41 2002 48 -0.14 0.021 1000 -1000 -0.041 -1000
LPA receptor mediated events 41 4267 102 -0.13 0.018 1000 -1000 -0.049 -1000
BCR signaling pathway 41 4142 99 -0.16 0.043 1000 -1000 -0.055 -1000
Caspase cascade in apoptosis 40 2970 74 -0.085 0.044 1000 -1000 -0.022 -1000
Syndecan-2-mediated signaling events 39 2696 69 -0.072 0.022 1000 -1000 -0.027 -1000
TCGA08_p53 39 277 7 -0.037 0.028 1000 -1000 -0.003 -1000
Signaling events mediated by PTP1B 37 2848 76 -0.15 0.055 1000 -1000 -0.047 -1000
Integrins in angiogenesis 37 3151 84 -0.18 0.031 1000 -1000 -0.058 -1000
Canonical Wnt signaling pathway 37 1906 51 -0.25 0.098 1000 -1000 -0.025 -1000
Calcium signaling in the CD4+ TCR pathway 36 1146 31 -0.14 0.026 1000 -1000 -0.034 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 35 1607 45 -0.13 0.018 1000 -1000 -0.057 -1000
Visual signal transduction: Rods 35 1868 52 -0.1 0.027 1000 -1000 -0.052 -1000
Ras signaling in the CD4+ TCR pathway 35 611 17 -0.038 0.013 1000 -1000 -0.006 -1000
IL1-mediated signaling events 34 2135 62 -0.082 0.051 1000 -1000 -0.052 -1000
Glypican 2 network 34 138 4 -0.016 0 1000 -1000 -0.002 -1000
Coregulation of Androgen receptor activity 33 2561 76 -0.18 0.029 1000 -1000 -0.015 -1000
Glypican 1 network 33 1618 48 -0.064 0.017 1000 -1000 -0.024 -1000
Signaling mediated by p38-gamma and p38-delta 33 504 15 -0.07 0.014 1000 -1000 -0.011 -1000
Class IB PI3K non-lipid kinase events 33 99 3 -0.004 -1000 1000 -1000 -0.001 -1000
Regulation of nuclear SMAD2/3 signaling 32 4415 136 -0.2 0.066 1000 -1000 -0.025 -1000
TRAIL signaling pathway 32 1581 48 -0.05 0.018 1000 -1000 -0.052 -1000
E-cadherin signaling in the nascent adherens junction 32 2487 76 -0.078 0.024 1000 -1000 -0.051 -1000
Presenilin action in Notch and Wnt signaling 31 1942 61 -0.22 0.036 1000 -1000 -0.036 -1000
Syndecan-3-mediated signaling events 31 1104 35 -0.099 0.033 1000 -1000 -0.026 -1000
Nectin adhesion pathway 30 1946 63 -0.11 0.024 1000 -1000 -0.051 -1000
Reelin signaling pathway 30 1695 56 -0.089 0.038 1000 -1000 -0.048 -1000
Visual signal transduction: Cones 29 1108 38 -0.072 0.025 1000 -1000 -0.005 -1000
Cellular roles of Anthrax toxin 29 1169 39 -0.14 0.018 1000 -1000 -0.015 -1000
PDGFR-alpha signaling pathway 29 1307 44 -0.18 0.028 1000 -1000 -0.011 -1000
Regulation of Telomerase 28 2899 102 -0.2 0.044 1000 -1000 -0.073 -1000
IFN-gamma pathway 27 1843 68 -0.086 0.023 1000 -1000 -0.054 -1000
IL2 signaling events mediated by STAT5 27 594 22 -0.073 0.021 1000 -1000 -0.016 -1000
Class I PI3K signaling events 27 2031 73 -0.089 0.031 1000 -1000 -0.03 -1000
Insulin Pathway 27 2032 74 -0.16 0.05 1000 -1000 -0.053 -1000
E-cadherin signaling in keratinocytes 27 1175 43 -0.079 0.018 1000 -1000 -0.018 -1000
p75(NTR)-mediated signaling 26 3260 125 -0.13 0.036 1000 -1000 -0.054 -1000
Ceramide signaling pathway 26 1987 76 -0.14 0.055 1000 -1000 -0.019 -1000
Aurora B signaling 26 1742 67 -0.095 0.02 1000 -1000 -0.043 -1000
RXR and RAR heterodimerization with other nuclear receptor 25 1317 52 -0.11 0.037 1000 -1000 -0.03 -1000
Effects of Botulinum toxin 25 675 26 -0.17 0.019 1000 -1000 -0.009 -1000
TCGA08_rtk_signaling 25 665 26 -0.079 0.039 1000 -1000 -0.01 -1000
FOXA2 and FOXA3 transcription factor networks 24 1132 46 -0.2 0.074 1000 -1000 -0.021 -1000
Regulation of Androgen receptor activity 23 1647 70 -0.18 0.026 1000 -1000 -0.032 -1000
Sphingosine 1-phosphate (S1P) pathway 22 625 28 -0.079 0.021 1000 -1000 -0.011 -1000
S1P1 pathway 22 817 36 -0.061 0.018 1000 -1000 -0.041 -1000
PLK1 signaling events 21 1867 85 -0.1 0.028 1000 -1000 -0.035 -1000
Atypical NF-kappaB pathway 21 681 31 -0.074 0.028 1000 -1000 -0.011 -1000
Angiopoietin receptor Tie2-mediated signaling 21 1870 88 -0.16 0.052 1000 -1000 -0.076 -1000
Arf6 downstream pathway 20 900 43 -0.022 0.019 1000 -1000 -0.027 -1000
mTOR signaling pathway 20 1092 53 -0.037 0.035 1000 -1000 -0.043 -1000
Aurora A signaling 19 1173 60 -0.037 0.034 1000 -1000 -0.01 -1000
HIF-2-alpha transcription factor network 19 855 43 -0.081 0.082 1000 -1000 -0.054 -1000
PDGFR-beta signaling pathway 19 1883 97 -0.082 0.036 1000 -1000 -0.052 -1000
Signaling events mediated by PRL 19 659 34 -0.095 0.026 1000 -1000 -0.017 -1000
EPHB forward signaling 18 1560 85 -0.039 0.038 1000 -1000 -0.057 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 18 608 33 -0.074 0.049 1000 -1000 -0.02 -1000
p38 MAPK signaling pathway 18 797 44 -0.078 0.034 1000 -1000 -0.05 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 17 956 54 -0.092 0.031 1000 -1000 -0.06 -1000
Hedgehog signaling events mediated by Gli proteins 17 1165 65 -0.051 0.041 1000 -1000 -0.048 -1000
ceramide signaling pathway 17 881 49 -0.11 0.037 1000 -1000 -0.021 -1000
Regulation of p38-alpha and p38-beta 17 969 54 -0.074 0.043 1000 -1000 -0.036 -1000
S1P3 pathway 17 745 42 -0.079 0.021 1000 -1000 -0.014 -1000
ErbB2/ErbB3 signaling events 16 1095 65 -0.059 0.024 1000 -1000 -0.044 -1000
BARD1 signaling events 16 949 57 -0.041 0.04 1000 -1000 -0.018 -1000
JNK signaling in the CD4+ TCR pathway 16 280 17 -0.036 0.029 1000 -1000 -0.018 -1000
Signaling events mediated by HDAC Class III 16 669 40 -0.077 0.034 1000 -1000 -0.023 -1000
Retinoic acid receptors-mediated signaling 16 930 58 -0.085 0.04 1000 -1000 -0.057 -1000
Signaling mediated by p38-alpha and p38-beta 16 733 44 -0.09 0.025 1000 -1000 -0.009 -1000
Signaling events mediated by VEGFR1 and VEGFR2 16 2032 125 -0.06 0.055 1000 -1000 -0.062 -1000
Neurotrophic factor-mediated Trk receptor signaling 16 2039 120 -0.12 0.053 1000 -1000 -0.047 -1000
Paxillin-independent events mediated by a4b1 and a4b7 15 567 37 -0.023 0.028 1000 -1000 -0.015 -1000
VEGFR1 specific signals 15 860 56 -0.035 0.026 1000 -1000 -0.025 -1000
LPA4-mediated signaling events 14 178 12 -0.03 0.015 1000 -1000 -0.002 -1000
a4b1 and a4b7 Integrin signaling 14 70 5 -0.007 0.018 1000 -1000 -0.007 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 14 1245 85 -0.14 0.039 1000 -1000 -0.047 -1000
EPO signaling pathway 14 792 55 -0.15 0.024 1000 -1000 -0.05 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 14 1244 83 -0.11 0.057 1000 -1000 -0.023 -1000
Signaling events mediated by HDAC Class II 12 949 75 -0.16 0.039 1000 -1000 -0.032 -1000
Paxillin-dependent events mediated by a4b1 12 432 36 -0.032 0.035 1000 -1000 -0.042 -1000
Nephrin/Neph1 signaling in the kidney podocyte 10 361 34 -0.009 0.035 1000 -1000 -0.013 -1000
Aurora C signaling 10 70 7 -0.007 0.016 1000 -1000 -0.033 -1000
FoxO family signaling 10 655 64 -0.12 0.068 1000 -1000 -0.021 -1000
Circadian rhythm pathway 9 202 22 -0.046 0.042 1000 -1000 -0.016 -1000
S1P5 pathway 9 161 17 -0.017 0.018 1000 -1000 -0.01 -1000
Alternative NF-kappaB pathway 9 117 13 0 0.034 1000 -1000 -0.005 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 8 193 23 -0.03 0.033 1000 -1000 -0.014 -1000
Canonical NF-kappaB pathway 8 342 39 -0.056 0.06 1000 -1000 -0.056 -1000
Ephrin A reverse signaling 8 60 7 0 0.015 1000 -1000 -0.007 -1000
Class I PI3K signaling events mediated by Akt 6 415 68 -0.038 0.052 1000 -1000 -0.02 -1000
Arf6 trafficking events 6 434 71 -0.021 0.031 1000 -1000 -0.046 -1000
S1P4 pathway 6 173 25 -0.017 0.021 1000 -1000 -0.013 -1000
Insulin-mediated glucose transport 5 178 32 -0.015 0.033 1000 -1000 -0.011 -1000
Signaling events mediated by HDAC Class I 5 527 104 -0.033 0.053 1000 -1000 -0.032 -1000
Rapid glucocorticoid signaling 5 117 20 -0.005 0.02 1000 -1000 -0.006 -1000
Arf1 pathway 3 164 54 -0.001 0.036 1000 -1000 -0.021 -1000
Sumoylation by RanBP2 regulates transcriptional repression 1 40 27 -0.001 0.04 1000 -1000 -0.037 -1000
Total 4443 264413 7203 -15 -990 131000 -131000 -4.5 -131000
Signaling events regulated by Ret tyrosine kinase

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.057 0.13 -9999 0 -0.74 13 13
Crk/p130 Cas/Paxillin -0.17 0.18 -9999 0 -0.4 164 164
JUN -0.17 0.21 -9999 0 -0.45 142 142
HRAS 0.012 0.051 -9999 0 -0.41 7 7
RET51/GFRalpha1/GDNF/GRB10 -0.21 0.22 -9999 0 -0.38 277 277
RAP1A 0.012 0.057 -9999 0 -0.52 6 6
FRS2 0.011 0.047 -9999 0 -0.27 13 13
RAP1A/GDP 0.009 0.041 -9999 0 -0.38 6 6
RET51/GFRalpha1/GDNF/DOK1 -0.21 0.22 -9999 0 -0.39 271 271
EntrezGene:5979 0 0 -9999 0 -10000 0 0
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.016 0.033 -9999 0 -0.52 2 2
RET9/GFRalpha1/GDNF/Enigma -0.1 0.14 -9999 0 -0.28 188 188
RHOA 0.005 0.08 -9999 0 -0.52 12 12
RAP1A/GTP -0.18 0.19 -9999 0 -0.36 245 245
GRB7 -0.017 0.1 -9999 0 -0.29 59 59
RET51/GFRalpha1/GDNF -0.2 0.21 -9999 0 -0.38 265 265
MAPKKK cascade -0.18 0.19 -9999 0 -0.45 145 145
BCAR1 0.017 0.012 -9999 0 -0.25 1 1
RET9/GFRalpha1/GDNF/IRS1 -0.14 0.19 -9999 0 -0.35 199 199
lamellipodium assembly -0.16 0.16 -9999 0 -0.33 220 220
RET51/GFRalpha1/GDNF/SHC -0.2 0.21 -9999 0 -0.38 266 266
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
RET9/GFRalpha1/GDNF/SHC -0.1 0.14 -9999 0 -0.28 189 189
RET9/GFRalpha1/GDNF/Shank3 -0.1 0.14 -9999 0 -0.28 190 190
MAPK3 -0.16 0.18 -9999 0 -0.43 135 135
DOK1 0.002 0.083 -9999 0 -0.41 19 19
DOK6 -0.028 0.14 -9999 0 -0.44 52 52
PXN 0.018 0 -9999 0 -10000 0 0
neurite development -0.16 0.19 -9999 0 -0.41 144 144
DOK5 -0.028 0.14 -9999 0 -0.38 60 60
GFRA1 -0.22 0.24 -9999 0 -0.43 282 282
MAPK8 -0.16 0.2 -9999 0 -0.43 145 145
HRAS/GTP -0.21 0.22 -9999 0 -0.41 242 242
tube development -0.091 0.13 -9999 0 -0.26 193 193
MAPK1 -0.17 0.18 -9999 0 -0.43 135 135
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.079 0.12 -9999 0 -0.24 189 189
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
SRC 0.015 0.035 -9999 0 -0.43 3 3
PDLIM7 0.017 0.012 -9999 0 -0.25 1 1
RET51/GFRalpha1/GDNF/Dok6 -0.2 0.23 -9999 0 -0.4 251 251
SHC1 0.017 0.023 -9999 0 -0.52 1 1
RET51/GFRalpha1/GDNF/Dok4 -0.2 0.21 -9999 0 -0.38 269 269
RET51/GFRalpha1/GDNF/Dok5 -0.22 0.23 -9999 0 -0.41 277 277
PRKCA 0.014 0.033 -9999 0 -0.25 8 8
HRAS/GDP 0.009 0.036 -9999 0 -0.29 7 7
CREB1 -0.14 0.19 -9999 0 -0.38 189 189
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.083 0.14 -9999 0 -0.25 192 192
RET51/GFRalpha1/GDNF/Grb7 -0.22 0.22 -9999 0 -0.4 275 275
mol:GDP 0 0 -9999 0 -10000 0 0
RET -0.18 0.23 -9999 0 -0.41 247 247
DOK4 0.013 0.047 -9999 0 -0.37 7 7
JNK cascade -0.16 0.2 -9999 0 -0.44 142 142
RET9/GFRalpha1/GDNF/FRS2 -0.11 0.14 -9999 0 -0.28 190 190
SHANK3 0.016 0.033 -9999 0 -0.52 2 2
RASA1 0.004 0.078 -9999 0 -0.42 16 16
NCK1 0.011 0.045 -9999 0 -0.28 12 12
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.077 0.12 -9999 0 -0.23 189 189
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.16 0.19 -9999 0 -0.43 133 133
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.17 0.21 -9999 0 -0.46 143 143
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.18 0.23 -9999 0 -0.54 131 131
PI3K -0.23 0.28 -9999 0 -0.52 219 219
SOS1 0.017 0.023 -9999 0 -0.52 1 1
RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.09 0.14 -9999 0 -0.26 193 193
GRB10 -0.003 0.097 -9999 0 -0.43 24 24
activation of MAPKK activity -0.13 0.16 -9999 0 -0.37 122 122
RET51/GFRalpha1/GDNF/FRS2 -0.2 0.21 -9999 0 -0.38 268 268
GAB1 0.006 0.074 -9999 0 -0.43 14 14
IRS1 -0.048 0.17 -9999 0 -0.49 68 68
IRS2 -0.026 0.13 -9999 0 -0.39 57 57
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.19 0.24 -9999 0 -0.55 136 136
RET51/GFRalpha1/GDNF/PKC alpha -0.2 0.21 -9999 0 -0.38 265 265
GRB2 0.016 0.024 -9999 0 -0.25 4 4
PRKACA 0.018 0 -9999 0 -10000 0 0
GDNF 0.014 0.042 -9999 0 -0.45 4 4
RAC1 0.018 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 -0.23 0.26 -9999 0 -0.43 274 274
Rac1/GTP -0.19 0.2 -9999 0 -0.4 220 220
RET9/GFRalpha1/GDNF -0.12 0.15 -9999 0 -0.32 188 188
GFRalpha1/GDNF -0.15 0.18 -9999 0 -0.37 188 188
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.15 0.21 -10000 0 -0.42 163 163
CRKL -0.16 0.22 -10000 0 -0.45 165 165
HRAS -0.12 0.19 -10000 0 -0.38 143 143
mol:PIP3 -0.15 0.2 0.24 1 -0.42 159 160
SPRED1 -0.002 0.098 -10000 0 -0.47 21 21
SPRED2 -0.003 0.1 -10000 0 -0.5 21 21
GAB1 -0.17 0.23 -10000 0 -0.47 168 168
FOXO3 -0.14 0.2 -10000 0 -0.42 155 155
AKT1 -0.16 0.21 -10000 0 -0.44 164 164
BAD -0.14 0.2 -10000 0 -0.41 159 159
megakaryocyte differentiation -0.17 0.23 -10000 0 -0.47 166 166
GSK3B -0.14 0.2 -10000 0 -0.41 159 159
RAF1 -0.088 0.16 -10000 0 -0.33 91 91
SHC1 0.017 0.023 -10000 0 -0.52 1 1
STAT3 -0.17 0.22 -10000 0 -0.47 163 163
STAT1 -0.37 0.49 -10000 0 -0.92 205 205
HRAS/SPRED1 -0.095 0.17 -10000 0 -0.35 99 99
cell proliferation -0.17 0.22 -10000 0 -0.45 165 165
PIK3CA 0.015 0.029 -10000 0 -0.34 3 3
TEC 0.013 0.052 -10000 0 -0.52 5 5
RPS6KB1 -0.17 0.22 -10000 0 -0.46 169 169
HRAS/SPRED2 -0.095 0.17 -10000 0 -0.35 96 96
LYN/TEC/p62DOK -0.15 0.22 -10000 0 -0.45 163 163
MAPK3 -0.053 0.12 -10000 0 -0.26 54 54
STAP1 -0.19 0.24 -10000 0 -0.48 176 176
GRAP2 0.012 0.042 -10000 0 -0.28 10 10
JAK2 -0.31 0.4 -10000 0 -0.75 213 213
STAT1 (dimer) -0.36 0.47 -10000 0 -0.89 205 205
mol:Gleevec 0.005 0.008 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.16 0.23 -10000 0 -0.45 168 168
actin filament polymerization -0.17 0.22 -10000 0 -0.44 182 182
LYN 0.014 0.031 -10000 0 -0.25 7 7
STAP1/STAT5A (dimer) -0.24 0.31 -10000 0 -0.64 166 166
PIK3R1 -0.01 0.11 -10000 0 -0.42 33 33
CBL/CRKL/GRB2 -0.13 0.2 -10000 0 -0.41 153 153
PI3K -0.16 0.23 -10000 0 -0.45 169 169
PTEN -0.001 0.1 -10000 0 -0.52 19 19
SCF/KIT/EPO/EPOR -0.39 0.54 -10000 0 -1.2 152 152
MAPK8 -0.17 0.22 -10000 0 -0.46 165 165
STAT3 (dimer) -0.17 0.22 -10000 0 -0.46 163 163
positive regulation of transcription -0.042 0.1 -10000 0 -0.21 53 53
mol:GDP -0.12 0.2 -10000 0 -0.4 148 148
PIK3C2B -0.17 0.22 -10000 0 -0.47 164 164
CBL/CRKL -0.14 0.21 -10000 0 -0.42 165 165
FER -0.17 0.22 -10000 0 -0.47 163 163
SH2B3 -0.17 0.22 -10000 0 -0.46 163 163
PDPK1 -0.14 0.18 -10000 0 -0.39 150 150
SNAI2 -0.19 0.25 -10000 0 -0.5 177 177
positive regulation of cell proliferation -0.27 0.36 -10000 0 -0.67 213 213
KITLG -0.096 0.2 -10000 0 -0.45 123 123
cell motility -0.27 0.36 -10000 0 -0.67 213 213
PTPN6 0.023 0.037 -10000 0 -0.43 3 3
EPOR -0.091 0.16 -10000 0 -0.96 2 2
STAT5A (dimer) -0.22 0.3 -10000 0 -0.59 187 187
SOCS1 0.015 0.031 -10000 0 -0.32 4 4
cell migration 0.17 0.22 0.46 170 -10000 0 170
SOS1 0.017 0.023 -10000 0 -0.52 1 1
EPO -0.03 0.099 -10000 0 -0.26 80 80
VAV1 -0.014 0.12 -10000 0 -0.39 42 42
GRB10 -0.18 0.23 -10000 0 -0.47 168 168
PTPN11 0.022 0.024 -10000 0 -0.5 1 1
SCF/KIT -0.18 0.23 -10000 0 -0.47 181 181
GO:0007205 0.008 0.011 -10000 0 -10000 0 0
MAP2K1 -0.063 0.13 -10000 0 -0.28 58 58
CBL 0.017 0.012 -10000 0 -0.25 1 1
KIT -0.33 0.53 -10000 0 -1.2 131 131
MAP2K2 -0.064 0.13 -10000 0 -0.29 59 59
SHC/Grb2/SOS1 -0.14 0.22 -10000 0 -0.43 161 161
STAT5A -0.23 0.31 -10000 0 -0.61 186 186
GRB2 0.016 0.024 -10000 0 -0.25 4 4
response to radiation -0.19 0.24 -10000 0 -0.49 177 177
SHC/GRAP2 0.022 0.034 -10000 0 -0.37 2 2
PTPRO -0.18 0.23 -10000 0 -0.48 166 166
SH2B2 -0.18 0.22 -10000 0 -0.44 182 182
DOK1 0.002 0.083 -10000 0 -0.41 19 19
MATK -0.18 0.23 -10000 0 -0.47 170 170
CREBBP 0.003 0.059 -10000 0 -0.54 2 2
BCL2 -0.33 0.55 -10000 0 -1.3 120 120
FOXM1 transcription factor network

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 -0.24 0.57 -10000 0 -1.1 111 111
PLK1 0.024 0.058 -10000 0 -10000 0 0
BIRC5 -0.092 0.39 -10000 0 -1.4 40 40
HSPA1B -0.25 0.56 -10000 0 -1.1 127 127
MAP2K1 0.018 0.047 -10000 0 -0.3 1 1
BRCA2 -0.26 0.59 -10000 0 -1.2 121 121
FOXM1 -0.4 0.94 -10000 0 -1.7 126 126
XRCC1 -0.24 0.57 -10000 0 -1.1 113 113
FOXM1B/p19 -0.42 0.55 0.45 1 -1.2 140 141
Cyclin D1/CDK4 -0.3 0.57 -10000 0 -1.1 156 156
CDC2 -0.27 0.62 -10000 0 -1.2 114 114
TGFA -0.29 0.55 -10000 0 -1 147 147
SKP2 -0.24 0.57 -10000 0 -1.1 111 111
CCNE1 -0.019 0.1 -10000 0 -0.29 64 64
CKS1B -0.24 0.57 -10000 0 -1.1 122 122
RB1 -0.22 0.32 -10000 0 -0.88 74 74
FOXM1C/SP1 -0.31 0.67 -10000 0 -1.3 130 130
AURKB 0.011 0.13 -10000 0 -1.4 3 3
CENPF -0.26 0.6 -10000 0 -1.2 117 117
CDK4 0.013 0.032 -10000 0 -0.26 5 5
MYC -0.22 0.52 -10000 0 -0.96 133 133
CHEK2 0.011 0.073 -10000 0 -0.41 9 9
ONECUT1 -0.28 0.57 -10000 0 -1.1 139 139
CDKN2A -0.056 0.15 -10000 0 -0.33 108 108
LAMA4 -0.24 0.58 -10000 0 -1.1 112 112
FOXM1B/HNF6 -0.37 0.71 -10000 0 -1.4 144 144
FOS -0.34 0.64 -10000 0 -1.2 158 158
SP1 0.017 0.024 -10000 0 -0.52 1 1
CDC25B -0.24 0.57 -10000 0 -1.1 111 111
response to radiation 0 0.039 -10000 0 -10000 0 0
CENPB -0.24 0.57 -10000 0 -1.1 106 106
CENPA -0.27 0.61 -10000 0 -1.2 113 113
NEK2 -0.29 0.62 -10000 0 -1.2 135 135
HIST1H2BA -0.24 0.57 -10000 0 -1.1 115 115
CCNA2 -0.027 0.14 -10000 0 -0.4 57 57
EP300 0.014 0.047 -10000 0 -0.52 4 4
CCNB1/CDK1 -0.32 0.7 -10000 0 -1.5 99 99
CCNB2 -0.25 0.59 -10000 0 -1.2 115 115
CCNB1 -0.27 0.62 -10000 0 -1.2 113 113
ETV5 -0.25 0.58 -10000 0 -1.1 114 114
ESR1 -0.43 0.71 -10000 0 -1.2 219 219
CCND1 -0.31 0.6 -10000 0 -1.1 157 157
GSK3A 0.019 0.037 -10000 0 -10000 0 0
Cyclin A-E1/CDK1-2 -0.014 0.13 -10000 0 -0.35 53 53
CDK2 0.011 0.048 -10000 0 -0.31 10 10
G2/M transition of mitotic cell cycle 0 0.046 -10000 0 -10000 0 0
FOXM1B/Cbp/p300 -0.38 0.53 -10000 0 -1.2 131 131
GAS1 -0.32 0.64 -10000 0 -1.2 149 149
MMP2 -0.28 0.62 -10000 0 -1.2 124 124
RB1/FOXM1C -0.31 0.6 -10000 0 -1.1 154 154
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
Syndecan-1-mediated signaling events

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.017 0.023 -9999 0 -0.52 1 1
CCL5 -0.051 0.18 -9999 0 -0.49 71 71
SDCBP 0.003 0.081 -9999 0 -0.4 19 19
FGFR/FGF2/Syndecan-1 -0.17 0.27 -9999 0 -0.46 180 180
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
Syndecan-1/Laminin-5 -0.16 0.26 -9999 0 -0.54 126 126
Syndecan-1/Syntenin -0.16 0.26 -9999 0 -0.53 129 129
MAPK3 -0.13 0.24 -9999 0 -0.53 104 104
HGF/MET 0.007 0.073 -9999 0 -0.38 13 13
TGFB1/TGF beta receptor Type II 0.017 0.023 -9999 0 -0.52 1 1
BSG 0.016 0.024 -9999 0 -0.25 4 4
keratinocyte migration -0.15 0.25 -9999 0 -0.53 126 126
Syndecan-1/RANTES -0.18 0.28 -9999 0 -0.53 157 157
Syndecan-1/CD147 -0.14 0.26 -9999 0 -0.54 117 117
Syndecan-1/Syntenin/PIP2 -0.15 0.25 -9999 0 -0.52 129 129
LAMA5 0.005 0.075 -9999 0 -0.41 15 15
positive regulation of cell-cell adhesion -0.15 0.24 -9999 0 -0.5 129 129
MMP7 -0.095 0.21 -9999 0 -0.44 129 129
HGF 0.008 0.069 -9999 0 -0.45 11 11
Syndecan-1/CASK -0.16 0.26 -9999 0 -0.44 180 180
Syndecan-1/HGF/MET -0.15 0.26 -9999 0 -0.55 116 116
regulation of cell adhesion -0.12 0.23 -9999 0 -0.51 106 106
HPSE -0.015 0.12 -9999 0 -0.39 43 43
positive regulation of cell migration -0.17 0.27 -9999 0 -0.46 180 180
SDC1 -0.17 0.27 -9999 0 -0.46 180 180
Syndecan-1/Collagen -0.17 0.27 -9999 0 -0.46 180 180
PPIB 0.014 0.044 -9999 0 -0.41 5 5
MET 0 0.075 -9999 0 -0.29 31 31
PRKACA 0.018 0 -9999 0 -10000 0 0
MMP9 -0.042 0.17 -9999 0 -0.51 60 60
MAPK1 -0.13 0.24 -9999 0 -0.53 106 106
homophilic cell adhesion -0.16 0.26 -9999 0 -0.45 180 180
MMP1 -0.19 0.22 -9999 0 -0.38 269 269
IGF1 pathway

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.015 0.026 -10000 0 -0.25 5 5
PTK2 0.016 0.029 -10000 0 -0.34 3 3
CRKL -0.1 0.19 -10000 0 -0.37 154 154
GRB2/SOS1/SHC 0.034 0.025 -10000 0 -0.3 2 2
HRAS 0.012 0.051 -10000 0 -0.41 7 7
IRS1/Crk -0.1 0.19 -10000 0 -0.36 154 154
IGF-1R heterotetramer/IGF1/PTP1B -0.11 0.18 -10000 0 -0.37 155 155
AKT1 -0.086 0.18 -10000 0 -0.42 84 84
BAD -0.075 0.17 -10000 0 -0.39 84 84
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.1 0.19 -10000 0 -0.36 154 154
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.1 0.19 -10000 0 -0.35 169 169
RAF1 -0.063 0.16 -10000 0 -0.39 70 70
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.088 0.19 -10000 0 -0.34 153 153
YWHAZ 0.017 0.017 -10000 0 -0.25 2 2
IGF-1R heterotetramer/IGF1/IRS1 -0.12 0.2 -10000 0 -0.38 169 169
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
RPS6KB1 -0.086 0.18 -10000 0 -0.4 95 95
GNB2L1 0.015 0.04 -10000 0 -0.52 3 3
positive regulation of MAPKKK cascade -0.058 0.14 -10000 0 -0.34 70 70
PXN 0.018 0 -10000 0 -10000 0 0
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
HRAS/GTP -0.099 0.15 -10000 0 -0.43 73 73
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.06 0.15 -10000 0 -0.35 71 71
IGF-1R heterotetramer -0.1 0.22 -10000 0 -0.51 110 110
IGF-1R heterotetramer/IGF1/IRS/Nck -0.1 0.19 -10000 0 -0.37 152 152
Crk/p130 Cas/Paxillin -0.078 0.18 -10000 0 -0.32 154 154
IGF1R -0.1 0.22 -10000 0 -0.51 110 110
IGF1 -0.12 0.22 -10000 0 -0.44 146 146
IRS2/Crk -0.11 0.2 -10000 0 -0.36 166 166
PI3K -0.1 0.2 -10000 0 -0.36 164 164
apoptosis 0.057 0.15 0.34 84 -10000 0 84
HRAS/GDP 0.009 0.036 -10000 0 -0.29 7 7
PRKCD -0.096 0.21 -10000 0 -0.39 153 153
RAF1/14-3-3 E -0.048 0.14 -10000 0 -0.34 69 69
BAD/14-3-3 -0.061 0.16 -10000 0 -0.36 84 84
PRKCZ -0.09 0.18 -10000 0 -0.32 164 164
Crk/p130 Cas/Paxillin/FAK1 -0.087 0.14 -10000 0 -0.37 75 75
PTPN1 0.002 0.07 -10000 0 -0.28 28 28
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.11 0.22 -10000 0 -0.41 153 153
BCAR1 0.017 0.012 -10000 0 -0.25 1 1
IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.086 0.17 -10000 0 -0.32 163 163
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.017 0.023 -10000 0 -0.52 1 1
IRS1/NCK2 -0.1 0.19 -10000 0 -0.37 152 152
GRB10 -0.003 0.097 -10000 0 -0.43 24 24
PTPN11 -0.1 0.19 -10000 0 -0.35 169 169
IRS1 -0.12 0.2 -10000 0 -0.38 169 169
IRS2 -0.12 0.21 -10000 0 -0.37 181 181
IGF-1R heterotetramer/IGF1 -0.14 0.22 -10000 0 -0.46 156 156
GRB2 0.016 0.024 -10000 0 -0.25 4 4
PDPK1 -0.094 0.18 -10000 0 -0.33 164 164
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
PRKD1 -0.12 0.23 -10000 0 -0.42 155 155
SHC1 0.017 0.023 -10000 0 -0.52 1 1
Wnt signaling

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.13 0.21 -9999 0 -0.46 102 102
FZD6 -0.077 0.2 -9999 0 -0.45 108 108
WNT6 -0.011 0.087 -9999 0 -0.26 54 54
WNT4 -0.062 0.18 -9999 0 -0.45 90 90
FZD3 -0.03 0.15 -9999 0 -0.48 51 51
WNT5A -0.084 0.2 -9999 0 -0.43 120 120
WNT11 -0.013 0.089 -9999 0 -0.26 57 57
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.017 0.037 -10000 0 -0.36 3 3
NFATC2 -0.11 0.26 -10000 0 -0.59 81 81
NFATC3 -0.055 0.11 -10000 0 -0.24 74 74
CD40LG -0.32 0.43 -10000 0 -0.89 157 157
ITCH 0.006 0.085 -10000 0 -10000 0 0
CBLB 0.005 0.088 -10000 0 -0.59 1 1
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.23 0.38 -10000 0 -0.88 94 94
JUNB 0.011 0.055 -10000 0 -0.36 10 10
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.008 0.1 -10000 0 -0.27 48 48
T cell anergy -0.033 0.14 -10000 0 -0.39 48 48
TLE4 -0.071 0.23 -10000 0 -0.72 37 37
Jun/NFAT1-c-4/p21SNFT -0.3 0.45 -10000 0 -0.91 148 148
AP-1/NFAT1-c-4 -0.37 0.52 -10000 0 -1 158 158
IKZF1 -0.08 0.23 -10000 0 -0.69 43 43
T-helper 2 cell differentiation -0.22 0.35 -10000 0 -0.76 124 124
AP-1/NFAT1 -0.14 0.24 -10000 0 -0.5 121 121
CALM1 0.003 0.058 -10000 0 -10000 0 0
EGR2 -0.29 0.52 -10000 0 -1.1 115 115
EGR3 -0.37 0.58 -10000 0 -1.2 142 142
NFAT1/FOXP3 -0.064 0.2 -10000 0 -0.52 49 49
EGR1 -0.1 0.2 -10000 0 -0.39 156 156
JUN -0.035 0.15 -10000 0 -0.46 57 57
EGR4 0 0.007 -10000 0 -10000 0 0
mol:Ca2+ -0.016 0.06 -10000 0 -0.17 48 48
GBP3 -0.14 0.31 -10000 0 -0.74 95 95
FOSL1 0.016 0.024 -10000 0 -0.25 4 4
NFAT1-c-4/MAF/IRF4 -0.28 0.44 -10000 0 -0.85 161 161
DGKA -0.066 0.21 -10000 0 -0.68 34 34
CREM 0.016 0.017 -10000 0 -0.26 2 2
NFAT1-c-4/PPARG -0.3 0.46 -10000 0 -0.9 162 162
CTLA4 -0.052 0.18 -10000 0 -0.55 37 37
NFAT1-c-4 (dimer)/EGR1 -0.33 0.48 -10000 0 -0.94 166 166
NFAT1-c-4 (dimer)/EGR4 -0.28 0.44 -10000 0 -0.88 159 159
FOS -0.11 0.2 -10000 0 -0.37 171 171
IFNG -0.3 0.47 -10000 0 -1.1 94 94
T cell activation -0.17 0.29 -10000 0 -0.75 64 64
MAF -0.012 0.12 -10000 0 -0.44 35 35
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.22 0.38 0.73 152 -10000 0 152
TNF -0.3 0.42 -10000 0 -0.83 169 169
FASLG -0.43 0.65 -10000 0 -1.3 167 167
TBX21 -0.11 0.21 -10000 0 -0.46 137 137
BATF3 0 0.001 -10000 0 -10000 0 0
PRKCQ -0.018 0.11 -10000 0 -0.32 51 51
PTPN1 -0.069 0.2 -10000 0 -0.58 44 44
NFAT1-c-4/ICER1 -0.28 0.44 -10000 0 -0.88 156 156
GATA3 -0.1 0.23 -10000 0 -0.51 124 124
T-helper 1 cell differentiation -0.28 0.44 -10000 0 -1.1 97 97
IL2RA -0.25 0.35 -10000 0 -0.81 108 108
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.058 0.19 -10000 0 -0.53 43 43
E2F1 0.013 0.071 -10000 0 -0.36 16 16
PPARG -0.036 0.14 -10000 0 -0.33 81 81
SLC3A2 -0.06 0.19 -10000 0 -0.56 38 38
IRF4 -0.01 0.085 -10000 0 -0.26 52 52
PTGS2 -0.33 0.44 -10000 0 -0.89 161 161
CSF2 -0.33 0.43 -10000 0 -0.89 159 159
JunB/Fra1/NFAT1-c-4 -0.26 0.43 -10000 0 -0.84 156 156
IL4 -0.24 0.37 -10000 0 -0.8 123 123
IL5 -0.32 0.43 -10000 0 -0.88 158 158
IL2 -0.18 0.29 -10000 0 -0.78 61 61
IL3 -0.04 0.052 -10000 0 -10000 0 0
RNF128 -0.053 0.2 -10000 0 -0.6 47 47
NFATC1 -0.22 0.39 -10000 0 -0.73 152 152
CDK4 0.14 0.22 0.56 57 -10000 0 57
PTPRK -0.12 0.3 -10000 0 -0.71 89 89
IL8 -0.36 0.44 -10000 0 -0.92 162 162
POU2F1 0.027 0 -10000 0 -10000 0 0
Endothelins

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.043 0.26 0.28 54 -0.58 61 115
PTK2B 0.017 0.017 -10000 0 -0.25 2 2
mol:Ca2+ -0.071 0.26 -10000 0 -0.68 54 54
EDN1 -0.065 0.24 0.23 20 -0.5 98 118
EDN3 -0.1 0.18 -10000 0 -0.32 190 190
EDN2 -0.13 0.22 -10000 0 -0.41 185 185
HRAS/GDP -0.11 0.24 -10000 0 -0.47 119 119
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.087 0.22 -10000 0 -0.44 109 109
ADCY4 -0.043 0.21 -10000 0 -0.52 59 59
ADCY5 -0.06 0.22 -10000 0 -0.49 73 73
ADCY6 -0.041 0.21 -10000 0 -0.5 61 61
ADCY7 -0.046 0.22 -10000 0 -0.52 61 61
ADCY1 -0.04 0.21 -10000 0 -0.5 60 60
ADCY2 -0.075 0.24 -10000 0 -0.5 87 87
ADCY3 -0.044 0.21 -10000 0 -0.5 64 64
ADCY8 -0.043 0.21 -10000 0 -0.5 59 59
ADCY9 -0.05 0.22 -10000 0 -0.5 67 67
arachidonic acid secretion -0.12 0.26 -10000 0 -0.5 134 134
ETB receptor/Endothelin-1/Gq/GTP -0.079 0.18 -10000 0 -0.35 114 114
GNAO1 0.016 0.024 -10000 0 -0.25 4 4
HRAS 0.011 0.051 -10000 0 -0.41 7 7
ETA receptor/Endothelin-1/G12/GTP -0.002 0.27 0.36 73 -0.56 57 130
ETA receptor/Endothelin-1/Gs/GTP -0.007 0.26 0.34 72 -0.53 59 131
mol:GTP -0.001 0.006 -10000 0 -10000 0 0
COL3A1 -0.048 0.28 -10000 0 -0.67 59 59
EDNRB -0.03 0.13 -10000 0 -0.39 52 52
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.042 0.26 -10000 0 -0.62 58 58
CYSLTR1 -0.075 0.3 -10000 0 -0.65 83 83
SLC9A1 -0.01 0.15 0.2 56 -0.3 57 113
mol:GDP -0.12 0.26 -10000 0 -0.5 126 126
SLC9A3 -0.13 0.34 -10000 0 -0.66 126 126
RAF1 -0.13 0.25 -10000 0 -0.49 130 130
JUN -0.11 0.36 -10000 0 -0.98 62 62
JAK2 -0.043 0.26 0.28 56 -0.58 62 118
mol:IP3 -0.11 0.22 -10000 0 -0.44 121 121
ETA receptor/Endothelin-1 -0.019 0.32 0.42 77 -0.57 84 161
PLCB1 -0.086 0.18 -10000 0 -0.38 138 138
PLCB2 0.014 0.027 -10000 0 -0.39 2 2
ETA receptor/Endothelin-3 -0.074 0.19 -10000 0 -0.4 99 99
FOS -0.18 0.35 -10000 0 -0.87 92 92
Gai/GDP -0.007 0.14 -10000 0 -0.82 10 10
CRK 0.016 0.033 -10000 0 -0.52 2 2
mol:Ca ++ -0.14 0.32 -10000 0 -0.6 127 127
BCAR1 0.017 0.012 -10000 0 -0.25 1 1
PRKCB1 -0.13 0.24 -10000 0 -0.47 131 131
GNAQ -0.001 0.007 -10000 0 -10000 0 0
GNAZ 0.001 0.088 -10000 0 -0.44 19 19
GNAL 0.011 0.052 -10000 0 -0.33 11 11
Gs family/GDP -0.12 0.22 -10000 0 -0.46 116 116
ETA receptor/Endothelin-1/Gq/GTP -0.068 0.23 -10000 0 -0.45 101 101
MAPK14 -0.084 0.17 -10000 0 -0.37 98 98
TRPC6 -0.077 0.28 -10000 0 -0.74 50 50
GNAI2 0.006 0.075 -10000 0 -0.48 12 12
GNAI3 0.018 0 -10000 0 -10000 0 0
GNAI1 -0.017 0.12 -10000 0 -0.38 46 46
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.096 0.18 -10000 0 -0.35 130 130
ETB receptor/Endothelin-2 -0.11 0.18 -10000 0 -0.4 135 135
ETB receptor/Endothelin-3 -0.09 0.16 -10000 0 -0.37 94 94
ETB receptor/Endothelin-1 -0.068 0.21 -10000 0 -0.39 120 120
MAPK3 -0.17 0.34 -10000 0 -0.75 108 108
MAPK1 -0.17 0.34 -10000 0 -0.76 106 106
Rac1/GDP -0.1 0.24 -10000 0 -0.46 121 121
cAMP biosynthetic process -0.047 0.22 0.27 1 -0.48 74 75
MAPK8 -0.089 0.29 -10000 0 -0.68 74 74
SRC 0.015 0.035 -10000 0 -0.43 3 3
ETB receptor/Endothelin-1/Gi/GTP -0.037 0.15 -10000 0 -0.36 61 61
p130Cas/CRK/Src/PYK2 -0.1 0.25 -10000 0 -0.52 110 110
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.1 0.24 -10000 0 -0.48 114 114
COL1A2 -0.12 0.38 -10000 0 -0.81 99 99
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.095 0.22 -10000 0 -0.41 148 148
mol:DAG -0.11 0.22 -10000 0 -0.44 121 121
MAP2K2 -0.15 0.28 -10000 0 -0.6 118 118
MAP2K1 -0.15 0.28 -10000 0 -0.58 124 124
EDNRA -0.003 0.2 -10000 0 -0.57 48 48
positive regulation of muscle contraction -0.031 0.22 -10000 0 -0.51 61 61
Gq family/GDP -0.13 0.21 -10000 0 -0.49 102 102
HRAS/GTP -0.12 0.23 -10000 0 -0.45 129 129
PRKCH -0.099 0.22 -10000 0 -0.45 113 113
RAC1 0.018 0 -10000 0 -10000 0 0
PRKCA -0.098 0.22 -10000 0 -0.44 109 109
PRKCB -0.1 0.21 -10000 0 -0.42 125 125
PRKCE -0.099 0.22 -10000 0 -0.44 115 115
PRKCD -0.098 0.22 -10000 0 -0.45 110 110
PRKCG -0.097 0.22 -10000 0 -0.45 106 106
regulation of vascular smooth muscle contraction -0.21 0.41 -10000 0 -1.1 89 89
PRKCQ -0.11 0.23 -10000 0 -0.46 116 116
PLA2G4A -0.14 0.28 -10000 0 -0.54 134 134
GNA14 -0.081 0.18 -10000 0 -0.35 140 140
GNA15 0.001 0.077 -10000 0 -0.34 23 23
GNA12 0.018 0 -10000 0 -10000 0 0
GNA11 0.012 0.047 -10000 0 -0.52 4 4
Rac1/GTP -0.002 0.27 0.36 73 -0.55 58 131
MMP1 -0.25 0.4 -10000 0 -0.89 132 132
EGFR-dependent Endothelin signaling events

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.012 0.051 -9999 0 -0.41 7 7
EGFR -0.079 0.18 -9999 0 -0.35 139 139
EGF/EGFR -0.17 0.21 -9999 0 -0.37 229 229
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.085 0.16 -9999 0 -0.29 169 169
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA -0.03 0.15 -9999 0 -0.5 49 49
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF -0.14 0.23 -9999 0 -0.42 193 193
EGF/EGFR dimer/SHC -0.12 0.18 -9999 0 -0.35 174 174
mol:GDP -0.086 0.15 -9999 0 -0.29 169 169
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 -0.097 0.21 -9999 0 -0.43 135 135
GRB2/SOS1 0.024 0.023 -9999 0 -0.37 1 1
HRAS/GTP -0.1 0.12 -9999 0 -0.34 60 60
SHC1 0.017 0.023 -9999 0 -0.52 1 1
HRAS/GDP -0.081 0.14 -9999 0 -0.35 60 60
FRAP1 -0.078 0.14 -9999 0 -0.35 58 58
EGF/EGFR dimer -0.15 0.2 -9999 0 -0.42 173 173
SOS1 0.017 0.023 -9999 0 -0.52 1 1
GRB2 0.016 0.024 -9999 0 -0.25 4 4
ETA receptor/Endothelin-1 -0.089 0.19 -9999 0 -0.41 120 120
HIF-1-alpha transcription factor network

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.15 0.47 -9999 0 -0.94 99 99
HDAC7 0.001 0.006 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.13 0.39 -9999 0 -0.78 87 87
SMAD4 0.01 0.067 -9999 0 -0.49 9 9
ID2 -0.16 0.48 -9999 0 -0.94 103 103
AP1 -0.1 0.19 -9999 0 -0.42 114 114
ABCG2 -0.16 0.48 -9999 0 -0.94 103 103
HIF1A -0.055 0.19 -9999 0 -0.53 59 59
TFF3 -0.23 0.52 -9999 0 -0.95 139 139
GATA2 -0.013 0.096 -9999 0 -0.33 40 40
AKT1 -0.006 0.1 -9999 0 -0.45 8 8
response to hypoxia -0.02 0.084 -9999 0 -0.17 16 16
MCL1 -0.16 0.47 -9999 0 -0.92 103 103
NDRG1 -0.17 0.49 -9999 0 -0.96 102 102
SERPINE1 -0.17 0.48 -9999 0 -0.94 105 105
FECH -0.16 0.48 -9999 0 -0.94 105 105
FURIN -0.16 0.48 -9999 0 -0.94 101 101
NCOA2 0.009 0.063 -9999 0 -0.4 11 11
EP300 0.009 0.12 -9999 0 -0.38 12 12
HMOX1 -0.17 0.49 -9999 0 -0.95 106 106
BHLHE40 -0.17 0.46 -9999 0 -0.92 105 105
BHLHE41 -0.17 0.46 -9999 0 -0.92 105 105
HIF1A/ARNT/SMAD3/SMAD4/SP1 -0.008 0.16 -9999 0 -0.37 49 49
ENG 0.007 0.15 -9999 0 -0.35 43 43
JUN -0.037 0.15 -9999 0 -0.47 57 57
RORA -0.17 0.49 -9999 0 -0.94 110 110
ABCB1 -0.1 0.25 -9999 0 -1.2 24 24
TFRC -0.18 0.49 -9999 0 -0.95 109 109
CXCR4 -0.18 0.49 -9999 0 -0.95 109 109
TF -0.16 0.48 -9999 0 -0.93 103 103
CITED2 -0.16 0.48 -9999 0 -0.95 100 100
HIF1A/ARNT -0.2 0.54 -9999 0 -1.1 90 90
LDHA -0.043 0.15 -9999 0 -1.2 8 8
ETS1 -0.16 0.48 -9999 0 -0.94 102 102
PGK1 -0.16 0.47 -9999 0 -0.93 101 101
NOS2 -0.17 0.46 -9999 0 -0.92 105 105
ITGB2 -0.17 0.49 -9999 0 -0.94 111 111
ALDOA -0.16 0.48 -9999 0 -0.94 101 101
Cbp/p300/CITED2 -0.16 0.48 -9999 0 -0.99 91 91
FOS -0.11 0.2 -9999 0 -0.38 171 171
HK2 -0.16 0.47 -9999 0 -0.94 99 99
SP1 0.022 0.031 -9999 0 -0.52 1 1
GCK 0.011 0.2 -9999 0 -0.93 7 7
HK1 -0.16 0.47 -9999 0 -0.93 99 99
NPM1 -0.16 0.47 -9999 0 -0.93 101 101
EGLN1 -0.16 0.48 -9999 0 -0.94 103 103
CREB1 0.025 0.024 -9999 0 -0.52 1 1
PGM1 -0.16 0.48 -9999 0 -0.94 103 103
SMAD3 0.005 0.079 -9999 0 -0.41 17 17
EDN1 -0.22 0.48 -9999 0 -1.2 98 98
IGFBP1 -0.16 0.47 -9999 0 -0.93 101 101
VEGFA -0.086 0.36 -9999 0 -0.71 83 83
HIF1A/JAB1 -0.038 0.14 -9999 0 -0.38 62 62
CP -0.25 0.51 -9999 0 -0.98 127 127
CXCL12 -0.18 0.51 -9999 0 -1 106 106
COPS5 0.01 0.056 -9999 0 -0.35 11 11
SMAD3/SMAD4 0.013 0.074 -9999 0 -0.36 18 18
BNIP3 -0.16 0.48 -9999 0 -0.92 108 108
EGLN3 -0.2 0.5 -9999 0 -0.99 109 109
CA9 -0.17 0.49 -9999 0 -0.96 103 103
TERT -0.16 0.48 -9999 0 -0.94 99 99
ENO1 -0.16 0.48 -9999 0 -0.94 100 100
PFKL -0.16 0.48 -9999 0 -0.94 101 101
NCOA1 0.011 0.057 -9999 0 -0.52 6 6
ADM -0.2 0.51 -9999 0 -0.98 113 113
ARNT 0.003 0.076 -9999 0 -10000 0 0
HNF4A 0.02 0.035 -9999 0 -0.52 2 2
ADFP -0.17 0.49 -9999 0 -0.94 111 111
SLC2A1 -0.085 0.36 -9999 0 -0.72 81 81
LEP -0.18 0.48 -9999 0 -0.92 112 112
HIF1A/ARNT/Cbp/p300 -0.13 0.4 -9999 0 -0.8 86 86
EPO -0.092 0.35 -9999 0 -0.76 57 57
CREBBP 0.01 0.12 -9999 0 -0.36 10 10
HIF1A/ARNT/Cbp/p300/HDAC7 -0.13 0.39 -9999 0 -0.8 83 83
PFKFB3 -0.16 0.48 -9999 0 -0.94 103 103
NT5E -0.16 0.48 -9999 0 -0.96 98 98
Fc-epsilon receptor I signaling in mast cells

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.007 0.074 -9999 0 -0.5 11 11
LAT2 -0.089 0.18 -9999 0 -0.34 142 142
AP1 -0.14 0.22 -9999 0 -0.47 132 132
mol:PIP3 -0.099 0.22 -9999 0 -0.4 151 151
IKBKB -0.043 0.12 -9999 0 -0.25 94 94
AKT1 -0.068 0.16 -9999 0 -0.4 73 73
IKBKG -0.041 0.12 -9999 0 -0.25 89 89
MS4A2 -0.15 0.23 -9999 0 -0.43 203 203
mol:Sphingosine-1-phosphate 0 0 -9999 0 -10000 0 0
PIK3CA 0.015 0.029 -9999 0 -0.34 3 3
MAP3K1 -0.086 0.19 -9999 0 -0.41 109 109
mol:Ca2+ -0.071 0.16 -9999 0 -0.3 151 151
LYN 0.012 0.032 -9999 0 -0.26 7 7
CBLB -0.086 0.18 -9999 0 -0.34 139 139
SHC1 0.017 0.023 -9999 0 -0.52 1 1
RasGAP/p62DOK -0.013 0.11 -9999 0 -0.3 58 58
positive regulation of cell migration -0.013 0.089 -9999 0 -0.28 46 46
INPP5D 0 0 -9999 0 -10000 0 0
PLD2 -0.088 0.18 -9999 0 -0.38 100 100
PTPN13 -0.12 0.22 -9999 0 -0.55 78 78
PTPN11 0.012 0.027 -9999 0 -0.56 1 1
GO:0007205 0 0 -9999 0 -10000 0 0
regulation of mast cell degranulation -0.046 0.14 -9999 0 -0.32 73 73
SYK -0.025 0.14 -9999 0 -0.49 43 43
GRB2 0.015 0.024 -9999 0 -0.26 4 4
LAT/PLCgamma1/GRB2/SLP76/GADs -0.14 0.2 -9999 0 -0.41 152 152
LAT -0.092 0.18 -9999 0 -0.34 143 143
PAK2 -0.081 0.2 -9999 0 -0.43 96 96
NFATC2 -0.042 0.082 -9999 0 -0.62 5 5
HRAS -0.096 0.21 -9999 0 -0.38 147 147
GAB2 0.009 0.048 -9999 0 -0.25 17 17
PLA2G1B 0.038 0.026 -9999 0 -10000 0 0
Fc epsilon R1 -0.12 0.2 -9999 0 -0.39 168 168
Antigen/IgE/Fc epsilon R1 -0.11 0.19 -9999 0 -0.35 168 168
mol:GDP -0.11 0.22 -9999 0 -0.41 149 149
JUN -0.034 0.15 -9999 0 -0.46 57 57
mol:Ca++ 0 0 -9999 0 -10000 0 0
PIK3R1 -0.01 0.11 -9999 0 -0.42 33 33
FOS -0.11 0.2 -9999 0 -0.37 171 171
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.097 0.18 -9999 0 -0.36 144 144
CHUK -0.046 0.12 -9999 0 -0.25 99 99
KLRG1 -0.084 0.17 -9999 0 -0.31 145 145
VAV1 -0.1 0.2 -9999 0 -0.36 149 149
calcium-dependent protein kinase C activity 0 0 -9999 0 -10000 0 0
CBL -0.086 0.18 -9999 0 -0.34 139 139
negative regulation of mast cell degranulation -0.079 0.16 -9999 0 -0.28 147 147
BTK -0.11 0.23 -9999 0 -0.42 147 147
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.13 0.25 -9999 0 -0.41 178 178
GAB2/PI3K/SHP2 -0.1 0.15 -9999 0 -0.43 74 74
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.097 0.2 -9999 0 -0.44 98 98
RAF1 0.029 0.026 -9999 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP -0.12 0.21 -9999 0 -0.36 184 184
FCER1G 0.02 0.026 -9999 0 -0.26 4 4
FCER1A -0.074 0.2 -9999 0 -0.51 91 91
Antigen/IgE/Fc epsilon R1/Fyn -0.095 0.18 -9999 0 -0.33 170 170
MAPK3 0.037 0.026 -9999 0 -10000 0 0
MAPK1 0.037 0.026 -9999 0 -10000 0 0
NFKB1 0.017 0.023 -9999 0 -0.52 1 1
MAPK8 -0.02 0.11 -9999 0 -0.48 19 19
DUSP1 -0.038 0.15 -9999 0 -0.41 69 69
NF-kappa-B/RelA -0.039 0.061 -9999 0 -0.18 41 41
actin cytoskeleton reorganization -0.088 0.18 -9999 0 -0.48 65 65
mol:Glucocorticoid Dexamethasone 0 0 -9999 0 -10000 0 0
PI3K -0.091 0.2 -9999 0 -0.45 99 99
FER -0.086 0.18 -9999 0 -0.34 140 140
RELA 0.018 0 -9999 0 -10000 0 0
ITK -0.053 0.13 -9999 0 -0.41 51 51
SOS1 0.017 0.023 -9999 0 -0.52 1 1
PLCG1 -0.1 0.22 -9999 0 -0.4 149 149
cytokine secretion -0.029 0.044 -9999 0 -0.16 4 4
SPHK1 -0.11 0.2 -9999 0 -0.35 167 167
PTK2 -0.092 0.19 -9999 0 -0.5 65 65
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.14 0.21 -9999 0 -0.42 149 149
EDG1 -0.013 0.089 -9999 0 -0.28 46 46
mol:DAG -0.095 0.22 -9999 0 -0.47 101 101
MAP2K2 0.032 0.031 -9999 0 -10000 0 0
MAP2K1 0.033 0.024 -9999 0 -10000 0 0
MAP2K7 0.017 0.023 -9999 0 -0.52 1 1
KLRG1/SHP2 -0.073 0.15 -9999 0 -0.37 77 77
MAP2K4 -0.011 0.16 -9999 0 -0.91 16 16
Fc epsilon R1/FcgammaRIIB -0.12 0.22 -9999 0 -0.38 184 184
mol:Choline -0.087 0.17 -9999 0 -0.38 100 100
SHC/Grb2/SOS1 -0.066 0.17 -9999 0 -0.41 74 74
FYN 0.008 0.067 -9999 0 -0.41 12 12
DOK1 0.002 0.083 -9999 0 -0.41 19 19
PXN -0.079 0.18 -9999 0 -0.46 65 65
HCLS1 -0.096 0.19 -9999 0 -0.36 145 145
PRKCB -0.069 0.16 -9999 0 -0.3 149 149
FCGR2B -0.031 0.15 -9999 0 -0.5 50 50
IGHE -0.003 0.006 -9999 0 -10000 0 0
KLRG1/SHIP -0.08 0.16 -9999 0 -0.29 145 145
LCP2 -0.004 0.098 -9999 0 -0.4 27 27
PLA2G4A -0.11 0.21 -9999 0 -0.38 157 157
RASA1 0.004 0.078 -9999 0 -0.42 16 16
mol:Phosphatidic acid -0.087 0.17 -9999 0 -0.38 100 100
IKK complex -0.023 0.098 -9999 0 -0.2 76 76
WIPF1 0.005 0.076 -9999 0 -0.4 16 16
Plasma membrane estrogen receptor signaling

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.058 0.14 -10000 0 -0.26 154 154
ER alpha/Gai/GDP/Gbeta gamma -0.089 0.19 -10000 0 -0.35 156 156
AKT1 -0.2 0.35 -10000 0 -0.74 152 152
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.2 0.35 -10000 0 -0.75 152 152
mol:Ca2+ -0.1 0.18 -10000 0 -0.44 88 88
IGF1R -0.083 0.2 -10000 0 -0.47 110 110
E2/ER alpha (dimer)/Striatin -0.09 0.15 -10000 0 -0.32 155 155
SHC1 0.017 0.023 -10000 0 -0.52 1 1
apoptosis 0.19 0.33 0.7 154 -10000 0 154
RhoA/GTP -0.086 0.12 -10000 0 -0.41 27 27
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.12 0.18 -10000 0 -0.38 155 155
regulation of stress fiber formation 0.041 0.12 0.29 41 -10000 0 41
E2/ERA-ERB (dimer) -0.086 0.15 -10000 0 -0.31 150 150
KRAS 0.009 0.065 -10000 0 -0.44 10 10
G13/GTP -0.08 0.14 -10000 0 -0.29 151 151
pseudopodium formation -0.041 0.12 -10000 0 -0.29 41 41
E2/ER alpha (dimer)/PELP1 -0.086 0.15 -10000 0 -0.31 150 150
GRB2 0.016 0.024 -10000 0 -0.25 4 4
GNG2 0.016 0.029 -10000 0 -0.34 3 3
GNAO1 0.016 0.024 -10000 0 -0.25 4 4
HRAS 0.012 0.051 -10000 0 -0.41 7 7
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.11 0.22 -10000 0 -0.44 153 153
E2/ER beta (dimer) 0.013 0.008 -10000 0 -0.17 1 1
mol:GDP -0.12 0.17 -10000 0 -0.39 150 150
mol:NADP -0.11 0.22 -10000 0 -0.44 153 153
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
mol:IP3 -0.11 0.19 -10000 0 -0.46 88 88
IGF-1R heterotetramer -0.083 0.2 -10000 0 -0.47 110 110
PLCB1 -0.12 0.19 -10000 0 -0.42 113 113
PLCB2 -0.074 0.17 -10000 0 -0.53 53 53
IGF1 -0.1 0.2 -10000 0 -0.41 146 146
mol:L-citrulline -0.11 0.22 -10000 0 -0.44 153 153
RHOA 0.005 0.08 -10000 0 -0.52 12 12
Gai/GDP -0.008 0.12 -10000 0 -0.75 10 10
JNK cascade 0.013 0.008 -10000 0 -0.17 1 1
BCAR1 0.017 0.012 -10000 0 -0.25 1 1
ESR2 0.017 0.012 -10000 0 -0.25 1 1
GNAQ 0 0 -10000 0 -10000 0 0
ESR1 -0.16 0.24 -10000 0 -0.46 199 199
Gq family/GDP/Gbeta gamma -0.024 0.12 -10000 0 -0.49 19 19
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 -0.044 0.13 -10000 0 -0.63 2 2
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.12 0.18 -10000 0 -0.38 156 156
GNAZ 0.001 0.088 -10000 0 -0.44 19 19
E2/ER alpha (dimer) -0.12 0.17 -10000 0 -0.33 199 199
STRN 0.011 0.056 -10000 0 -0.42 8 8
GNAL 0.011 0.052 -10000 0 -0.33 11 11
PELP1 0.018 0 -10000 0 -10000 0 0
MAPK11 0.021 0.007 -10000 0 -10000 0 0
GNAI2 0.006 0.075 -10000 0 -0.48 12 12
GNAI3 0.018 0 -10000 0 -10000 0 0
GNAI1 -0.017 0.12 -10000 0 -0.38 46 46
HBEGF -0.093 0.19 -10000 0 -0.41 71 71
cAMP biosynthetic process -0.081 0.11 -10000 0 -0.25 152 152
SRC -0.079 0.18 -10000 0 -0.33 157 157
PI3K 0.005 0.082 -10000 0 -0.37 21 21
GNB1 0.013 0.052 -10000 0 -0.52 5 5
G13/GDP/Gbeta gamma -0.1 0.15 -10000 0 -0.33 151 151
SOS1 0.017 0.023 -10000 0 -0.52 1 1
IGF-1R heterotetramer/IGF1 -0.16 0.21 -10000 0 -0.44 168 168
Gs family/GTP -0.066 0.13 -10000 0 -0.26 152 152
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.019 0.064 -10000 0 -0.28 20 20
vasodilation -0.1 0.22 -10000 0 -0.42 153 153
mol:DAG -0.11 0.19 -10000 0 -0.46 88 88
Gs family/GDP/Gbeta gamma -0.1 0.15 -10000 0 -0.32 152 152
MSN -0.045 0.13 -10000 0 -0.32 41 41
Gq family/GTP -0.084 0.18 -10000 0 -0.53 58 58
mol:PI-3-4-5-P3 -0.19 0.34 -10000 0 -0.72 152 152
NRAS 0.005 0.076 -10000 0 -0.4 16 16
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.1 0.22 0.42 153 -10000 0 153
GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
RhoA/GDP -0.093 0.18 -10000 0 -0.37 151 151
NOS3 -0.11 0.23 -10000 0 -0.46 153 153
GNA11 0.014 0.047 -10000 0 -0.52 4 4
MAPKKK cascade -0.12 0.26 -10000 0 -0.53 154 154
E2/ER alpha (dimer)/PELP1/Src -0.13 0.18 -10000 0 -0.4 155 155
ruffle organization -0.041 0.12 -10000 0 -0.29 41 41
ROCK2 -0.051 0.13 -10000 0 -0.37 29 29
GNA14 -0.079 0.18 -10000 0 -0.35 140 140
GNA15 0.002 0.076 -10000 0 -0.34 23 23
GNA13 0.011 0.055 -10000 0 -0.36 10 10
MMP9 -0.095 0.18 -10000 0 -0.4 63 63
MMP2 -0.09 0.2 -10000 0 -0.44 65 65
FAS signaling pathway (CD95)

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 0.067 0.099 0.23 128 -10000 0 128
RFC1 0.067 0.099 0.23 128 -10000 0 128
PRKDC 0.064 0.1 0.23 126 -0.3 1 127
RIPK1 0.018 0.024 -10000 0 -0.52 1 1
CASP7 -0.013 0.12 0.24 2 -0.68 14 16
FASLG/FAS/FADD/FAF1 -0.012 0.13 0.22 49 -0.3 48 97
MAP2K4 -0.045 0.16 -10000 0 -0.41 47 47
mol:ceramide -0.044 0.15 -10000 0 -0.38 59 59
GSN 0.056 0.11 0.24 123 -0.3 11 134
FASLG/FAS/FADD/FAF1/Caspase 8 -0.013 0.13 -10000 0 -0.36 41 41
FAS -0.026 0.13 -10000 0 -0.42 51 51
BID 0.012 0.066 0.29 16 -0.32 8 24
MAP3K1 -0.016 0.13 0.26 2 -0.34 40 42
MAP3K7 0.015 0.021 -10000 0 -0.25 3 3
RB1 0.054 0.11 0.23 117 -0.29 9 126
CFLAR 0.01 0.065 -10000 0 -0.44 10 10
HGF/MET -0.036 0.14 -10000 0 -0.33 90 90
ARHGDIB 0.044 0.12 0.23 113 -0.29 20 133
FADD -0.003 0.068 -10000 0 -0.26 35 35
actin filament polymerization -0.056 0.11 0.3 11 -0.23 123 134
NFKB1 -0.042 0.08 -10000 0 -0.85 1 1
MAPK8 -0.06 0.19 -10000 0 -0.47 71 71
DFFA 0.066 0.099 0.23 127 -10000 0 127
DNA fragmentation during apoptosis 0.066 0.098 0.23 127 -10000 0 127
FAS/FADD/MET -0.014 0.1 -10000 0 -0.33 39 39
CFLAR/RIP1 0.02 0.05 -10000 0 -0.36 8 8
FAIM3 -0.001 0.099 -10000 0 -0.49 20 20
FAF1 0.013 0.025 -10000 0 -0.52 1 1
PARP1 0.064 0.1 0.23 128 -0.28 5 133
DFFB 0.066 0.099 0.23 127 -10000 0 127
CHUK -0.025 0.091 -10000 0 -0.43 6 6
FASLG -0.065 0.17 -10000 0 -0.38 106 106
FAS/FADD -0.02 0.11 -10000 0 -0.36 37 37
HGF 0.008 0.069 -10000 0 -0.45 11 11
LMNA 0.06 0.095 0.22 112 -0.26 8 120
CASP6 0.063 0.1 0.23 126 -0.27 4 130
CASP10 0.012 0.029 -10000 0 -0.25 6 6
CASP3 0.072 0.12 0.28 128 -10000 0 128
PTPN13 -0.071 0.2 -10000 0 -0.49 93 93
CASP8 0.013 0.068 0.37 18 -10000 0 18
IL6 -0.16 0.4 -10000 0 -1.2 59 59
MET 0 0.075 -10000 0 -0.29 31 31
ICAD/CAD 0.066 0.089 0.22 115 -10000 0 115
FASLG/FAS/FADD/FAF1/Caspase 10 -0.045 0.15 -10000 0 -0.38 59 59
activation of caspase activity by cytochrome c 0.012 0.066 0.29 16 -0.32 8 24
PAK2 0.067 0.099 0.23 128 -10000 0 128
BCL2 -0.11 0.22 -10000 0 -0.47 144 144
IL6-mediated signaling events

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.11 0.3 -10000 0 -0.69 66 66
CRP -0.11 0.3 -10000 0 -0.67 73 73
cell cycle arrest -0.14 0.34 -10000 0 -0.73 96 96
TIMP1 -0.11 0.3 -10000 0 -0.73 67 67
IL6ST -0.11 0.22 -10000 0 -0.46 143 143
Rac1/GDP -0.1 0.22 0.28 2 -0.42 131 133
AP1 -0.05 0.16 -10000 0 -0.45 33 33
GAB2 0.011 0.048 -10000 0 -0.25 17 17
TNFSF11 -0.18 0.41 -10000 0 -0.96 91 91
HSP90B1 0.008 0.11 -10000 0 -0.8 6 6
GAB1 0.007 0.074 -10000 0 -0.42 14 14
MAPK14 -0.11 0.22 -10000 0 -0.49 84 84
AKT1 0.038 0.073 -10000 0 -0.47 3 3
FOXO1 0.036 0.086 -10000 0 -0.45 5 5
MAP2K6 -0.12 0.22 0.27 2 -0.4 149 151
mol:GTP 0 0.002 -10000 0 -10000 0 0
MAP2K4 -0.1 0.25 -10000 0 -0.48 119 119
MITF -0.11 0.22 0.29 2 -0.41 140 142
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 0.018 0 -10000 0 -10000 0 0
A2M -0.042 0.28 -10000 0 -1.4 22 22
CEBPB 0.013 0.073 -10000 0 -0.33 20 20
GRB2/SOS1/GAB family/SHP2 -0.017 0.1 -10000 0 -0.41 9 9
STAT3 -0.15 0.37 -10000 0 -0.78 96 96
STAT1 -0.042 0.17 -10000 0 -0.95 16 16
CEBPD -0.16 0.38 -10000 0 -0.9 85 85
PIK3CA 0.017 0.029 -10000 0 -0.34 3 3
PI3K 0.008 0.083 -10000 0 -0.37 21 21
JUN -0.034 0.15 -10000 0 -0.46 57 57
PIAS3/MITF -0.095 0.21 -10000 0 -0.44 100 100
MAPK11 -0.11 0.22 -10000 0 -0.48 88 88
STAT3 (dimer)/FOXO1 -0.082 0.29 -10000 0 -0.6 82 82
GRB2/SOS1/GAB family -0.11 0.18 -10000 0 -0.47 72 72
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.12 0.22 -10000 0 -0.39 168 168
GRB2 0.017 0.024 -10000 0 -0.25 4 4
JAK2 0.01 0.053 -10000 0 -0.32 12 12
LBP -0.097 0.26 -10000 0 -0.61 51 51
PIK3R1 -0.008 0.11 -10000 0 -0.42 33 33
JAK1 0.013 0.059 -10000 0 -0.53 6 6
MYC -0.14 0.37 -10000 0 -0.85 84 84
FGG -0.11 0.3 -10000 0 -0.67 75 75
macrophage differentiation -0.14 0.34 -10000 0 -0.73 96 96
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.13 0.2 -10000 0 -0.34 207 207
JUNB -0.11 0.29 -10000 0 -0.68 64 64
FOS -0.11 0.2 -10000 0 -0.37 171 171
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.12 0.22 0.31 2 -0.42 146 148
STAT1/PIAS1 -0.11 0.22 0.32 2 -0.42 128 130
GRB2/SOS1/GAB family/SHP2/PI3K 0.03 0.067 -10000 0 -0.38 4 4
STAT3 (dimer) -0.14 0.36 -10000 0 -0.77 96 96
PRKCD -0.1 0.27 -10000 0 -0.57 91 91
IL6R 0.002 0.085 -10000 0 -0.37 23 23
SOCS3 -0.1 0.23 -10000 0 -0.67 42 42
gp130 (dimer)/JAK1/JAK1/LMO4 -0.096 0.19 -10000 0 -0.35 170 170
Rac1/GTP -0.11 0.24 -10000 0 -0.45 120 120
HCK -0.005 0.11 -10000 0 -0.47 25 25
MAPKKK cascade 0.008 0.093 -10000 0 -0.55 4 4
bone resorption -0.16 0.38 -10000 0 -0.87 94 94
IRF1 -0.12 0.33 -10000 0 -0.79 68 68
mol:GDP -0.12 0.23 0.29 2 -0.41 150 152
SOS1 0.018 0.024 -10000 0 -0.52 1 1
VAV1 -0.12 0.23 0.29 2 -0.42 150 152
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.11 0.22 -10000 0 -0.48 90 90
PTPN11 0.004 0.058 -10000 0 -1.2 1 1
IL6/IL6RA -0.056 0.14 -10000 0 -0.36 79 79
gp130 (dimer)/TYK2/TYK2/LMO4 -0.095 0.18 -10000 0 -0.34 169 169
gp130 (dimer)/JAK2/JAK2/LMO4 -0.099 0.18 -10000 0 -0.35 174 174
IL6 -0.084 0.18 -10000 0 -0.36 146 146
PIAS3 0.018 0 -10000 0 -10000 0 0
PTPRE -0.002 0.088 -10000 0 -0.47 17 17
PIAS1 0.017 0.012 -10000 0 -0.25 1 1
RAC1 0.018 0.001 -10000 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.11 0.18 0.27 2 -0.32 195 197
LMO4 -0.073 0.18 -10000 0 -0.38 123 123
STAT3 (dimer)/PIAS3 -0.14 0.34 -10000 0 -0.72 97 97
MCL1 0.043 0.083 -10000 0 -0.82 2 2
TCGA08_retinoblastoma

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B -0.017 0.12 -10000 0 -0.38 46 46
CDKN2C 0.005 0.085 -10000 0 -0.37 23 23
CDKN2A -0.052 0.15 -10000 0 -0.32 107 107
CCND2 0.019 0.085 0.2 74 -0.15 6 80
RB1 -0.022 0.092 0.15 3 -0.22 77 80
CDK4 0.026 0.096 0.23 77 -10000 0 77
CDK6 0.019 0.093 0.23 63 -0.2 6 69
G1/S progression 0.022 0.092 0.22 77 -0.15 3 80
IL4-mediated signaling events

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.33 0.63 -10000 0 -1.3 118 118
STAT6 (cleaved dimer) -0.43 0.56 -10000 0 -1.2 144 144
IGHG1 -0.083 0.25 -10000 0 -0.48 45 45
IGHG3 -0.33 0.6 -10000 0 -1.2 139 139
AKT1 -0.11 0.31 -10000 0 -0.67 51 51
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.065 0.24 -10000 0 -0.61 27 27
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.14 0.34 -10000 0 -0.72 68 68
THY1 -0.35 0.65 -10000 0 -1.3 121 121
MYB -0.097 0.22 -10000 0 -0.49 119 119
HMGA1 0.014 0.039 -10000 0 -0.36 5 5
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.14 0.34 -10000 0 -0.64 94 94
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.12 0.31 -10000 0 -0.66 53 53
SP1 0.021 0.03 -10000 0 -0.53 1 1
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 0.016 0.055 -10000 0 -0.4 7 7
STAT6 (dimer)/ETS1 -0.34 0.63 -10000 0 -1.2 138 138
SOCS1 -0.18 0.4 -10000 0 -0.78 105 105
SOCS3 -0.12 0.33 -10000 0 -0.91 27 27
FCER2 -0.22 0.46 -10000 0 -0.91 103 103
PARP14 0.006 0.078 -10000 0 -0.43 15 15
CCL17 -0.42 0.71 -10000 0 -1.4 148 148
GRB2 0.016 0.024 -10000 0 -0.25 4 4
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.083 0.26 -10000 0 -0.63 27 27
T cell proliferation -0.35 0.65 -10000 0 -1.3 127 127
IL4R/JAK1 -0.35 0.64 -10000 0 -1.3 124 124
EGR2 -0.39 0.69 -10000 0 -1.4 136 136
JAK2 0.001 0.072 -10000 0 -0.34 12 12
JAK3 0.021 0.008 -10000 0 -10000 0 0
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
JAK1 0.012 0.061 -10000 0 -0.52 6 6
COL1A2 -0.22 0.54 -10000 0 -1.5 72 72
CCL26 -0.34 0.63 -10000 0 -1.3 118 118
IL4R -0.37 0.7 -10000 0 -1.4 121 121
PTPN6 0.021 0.038 -10000 0 -0.42 3 3
IL13RA2 -0.38 0.67 -10000 0 -1.3 141 141
IL13RA1 -0.002 0.089 -10000 0 -0.49 12 12
IRF4 -0.038 0.2 -10000 0 -0.76 11 11
ARG1 -0.064 0.27 -10000 0 -0.87 28 28
CBL -0.13 0.32 -10000 0 -0.61 91 91
GTF3A 0.02 0.032 -10000 0 -0.38 2 2
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
IL13RA1/JAK2 0.003 0.099 -10000 0 -0.36 18 18
IRF4/BCL6 -0.044 0.19 -10000 0 -0.71 11 11
CD40LG 0.012 0.07 -10000 0 -0.32 20 20
MAPK14 -0.13 0.33 -10000 0 -0.64 80 80
mitosis -0.1 0.3 -10000 0 -0.64 50 50
STAT6 -0.43 0.85 -10000 0 -1.6 139 139
SPI1 0.012 0.07 -10000 0 -0.41 12 12
RPS6KB1 -0.099 0.29 -10000 0 -0.63 44 44
STAT6 (dimer) -0.44 0.86 -10000 0 -1.6 139 139
STAT6 (dimer)/PARP14 -0.39 0.7 -10000 0 -1.4 140 140
mast cell activation 0.004 0.019 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.11 0.3 -10000 0 -0.67 49 49
FRAP1 -0.11 0.31 -10000 0 -0.67 51 51
LTA -0.33 0.63 -10000 0 -1.3 118 118
FES 0.01 0.058 -10000 0 -0.39 10 10
T-helper 1 cell differentiation 0.39 0.75 1.4 139 -10000 0 139
CCL11 -0.38 0.65 -10000 0 -1.3 141 141
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.1 0.3 -10000 0 -0.69 32 32
IL2RG 0.001 0.08 -10000 0 -0.29 35 35
IL10 -0.34 0.63 -10000 0 -1.3 123 123
IRS1 -0.048 0.17 -10000 0 -0.49 68 68
IRS2 -0.026 0.13 -10000 0 -0.39 57 57
IL4 -0.039 0.22 -10000 0 -1.4 6 6
IL5 -0.34 0.63 -10000 0 -1.3 119 119
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.24 0.5 -10000 0 -0.94 131 131
COL1A1 -0.23 0.56 -10000 0 -1.6 72 72
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.37 0.67 -10000 0 -1.4 120 120
IL2R gamma/JAK3 0.017 0.059 -10000 0 -0.33 5 5
TFF3 -0.52 0.77 -10000 0 -1.4 193 193
ALOX15 -0.35 0.64 -10000 0 -1.3 126 126
MYBL1 -0.066 0.17 -10000 0 -0.36 117 117
T-helper 2 cell differentiation -0.25 0.49 -10000 0 -0.95 130 130
SHC1 0.017 0.023 -10000 0 -0.52 1 1
CEBPB 0.008 0.075 -10000 0 -0.34 20 20
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.12 0.32 -10000 0 -0.73 44 44
mol:PI-3-4-5-P3 -0.11 0.31 -10000 0 -0.67 51 51
PI3K -0.12 0.33 -10000 0 -0.71 52 52
DOK2 -0.021 0.13 -10000 0 -0.4 48 48
ETS1 0.007 0.07 -10000 0 -0.28 24 24
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.073 0.25 -10000 0 -0.62 23 23
ITGB3 -0.34 0.63 -10000 0 -1.3 117 117
PIGR -0.5 0.76 -10000 0 -1.4 181 181
IGHE 0.022 0.086 0.2 52 -0.25 4 56
MAPKKK cascade -0.071 0.24 -10000 0 -0.6 23 23
BCL6 -0.004 0.1 -10000 0 -0.46 24 24
OPRM1 -0.34 0.63 -10000 0 -1.4 100 100
RETNLB -0.33 0.63 -10000 0 -1.3 116 116
SELP -0.46 0.75 -10000 0 -1.5 158 158
AICDA -0.35 0.61 -10000 0 -1.3 129 129
IL27-mediated signaling events

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.026 0.03 -10000 0 -0.46 2 2
CD4-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
cytokine production during immune response 0.17 0.26 0.61 102 -10000 0 102
IL27/IL27R/JAK1 -0.2 0.35 -10000 0 -0.86 84 84
TBX21 -0.22 0.3 -10000 0 -0.61 153 153
IL12B 0.001 0.075 -10000 0 -0.35 21 21
IL12A -0.01 0.064 -10000 0 -0.19 55 55
IL6ST -0.12 0.22 -10000 0 -0.47 143 143
IL27RA/JAK1 -0.11 0.33 -10000 0 -1.2 39 39
IL27 -0.082 0.2 -10000 0 -0.5 98 98
TYK2 0.011 0.011 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.006 0.11 -10000 0 -1.4 1 1
T-helper 2 cell differentiation 0.17 0.26 0.61 102 -10000 0 102
T cell proliferation during immune response 0.17 0.26 0.61 102 -10000 0 102
MAPKKK cascade -0.17 0.26 -10000 0 -0.61 102 102
STAT3 0.015 0.04 -10000 0 -0.52 3 3
STAT2 0.018 0 -10000 0 -10000 0 0
STAT1 -0.021 0.12 -10000 0 -0.33 58 58
IL12RB1 0.017 0.003 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.21 0.28 -10000 0 -0.58 158 158
IL27/IL27R/JAK2/TYK2 -0.17 0.27 -10000 0 -0.62 102 102
positive regulation of T cell mediated cytotoxicity -0.17 0.26 -10000 0 -0.61 102 102
STAT1 (dimer) -0.27 0.4 0.46 9 -0.91 104 113
JAK2 0.004 0.055 -10000 0 -0.33 12 12
JAK1 0.011 0.057 -10000 0 -0.52 6 6
STAT2 (dimer) -0.16 0.25 -10000 0 -0.58 102 102
T cell proliferation -0.2 0.27 -10000 0 -0.6 125 125
IL12/IL12R/TYK2/JAK2 -0.033 0.15 -10000 0 -0.85 9 9
IL17A -0.006 0.11 -10000 0 -1.4 1 1
mast cell activation 0.17 0.26 0.61 102 -10000 0 102
IFNG -0.031 0.047 -10000 0 -0.11 94 94
T cell differentiation -0.01 0.009 0.017 2 -0.021 176 178
STAT3 (dimer) -0.16 0.25 -10000 0 -0.58 103 103
STAT5A (dimer) -0.16 0.26 -10000 0 -0.59 104 104
STAT4 (dimer) -0.17 0.27 -10000 0 -0.59 120 120
STAT4 -0.024 0.13 -10000 0 -0.42 50 50
T cell activation 0.002 0.038 0.08 81 -10000 0 81
IL27R/JAK2/TYK2 -0.16 0.33 -10000 0 -0.93 63 63
GATA3 -0.25 0.55 -10000 0 -1.3 119 119
IL18 -0.035 0.12 -10000 0 -0.32 76 76
positive regulation of mast cell cytokine production -0.15 0.25 -10000 0 -0.57 103 103
IL27/EBI3 -0.06 0.16 -10000 0 -0.38 93 93
IL27RA -0.12 0.34 -10000 0 -1.3 38 38
IL6 -0.077 0.18 -10000 0 -0.35 147 147
STAT5A 0.011 0.056 -10000 0 -0.42 8 8
monocyte differentiation -0.001 0.002 -10000 0 -10000 0 0
IL2 0.054 0.16 0.49 38 -1.2 3 41
IL1B -0.033 0.12 -10000 0 -0.29 81 81
EBI3 0.002 0.071 -10000 0 -0.44 12 12
TNF -0.003 0.067 -10000 0 -0.25 31 31
Glucocorticoid receptor regulatory network

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.018 0.15 0.35 14 -0.84 10 24
SMARCC2 0.018 0 -10000 0 -10000 0 0
SMARCC1 0.012 0.051 -10000 0 -0.41 7 7
TBX21 -0.2 0.33 -10000 0 -0.74 124 124
SUMO2 0.014 0.022 -10000 0 -0.26 3 3
STAT1 (dimer) -0.023 0.13 -10000 0 -0.34 67 67
FKBP4 0.012 0.055 -10000 0 -0.44 7 7
FKBP5 -0.045 0.16 -10000 0 -0.42 75 75
GR alpha/HSP90/FKBP51/HSP90 0.073 0.16 0.29 76 -0.31 28 104
PRL -0.057 0.14 -10000 0 -0.87 3 3
cortisol/GR alpha (dimer)/TIF2 0.23 0.26 0.53 182 -0.4 2 184
RELA -0.052 0.091 -10000 0 -0.26 21 21
FGG 0.2 0.22 0.48 141 -0.38 3 144
GR beta/TIF2 0.11 0.14 0.3 109 -0.32 14 123
IFNG -0.41 0.43 -10000 0 -0.91 168 168
apoptosis -0.004 0.18 0.5 6 -0.55 5 11
CREB1 0.007 0.056 -10000 0 -0.36 5 5
histone acetylation -0.045 0.14 0.3 2 -0.35 51 53
BGLAP -0.072 0.15 -10000 0 -0.49 23 23
GR/PKAc 0.092 0.14 0.29 65 -0.33 14 79
NF kappa B1 p50/RelA -0.091 0.17 -10000 0 -0.4 63 63
SMARCD1 0.018 0 -10000 0 -10000 0 0
MDM2 0.099 0.1 0.24 137 -10000 0 137
GATA3 -0.093 0.23 -10000 0 -0.5 124 124
AKT1 0.006 0.059 0.21 4 -0.38 9 13
CSF2 -0.073 0.15 -10000 0 -0.87 7 7
GSK3B 0.016 0.008 -10000 0 -10000 0 0
NR1I3 0.009 0.18 0.52 2 -0.91 3 5
CSN2 0.17 0.18 0.42 110 -0.46 2 112
BRG1/BAF155/BAF170/BAF60A 0.041 0.034 -10000 0 -0.27 5 5
NFATC1 -0.004 0.12 -10000 0 -0.41 39 39
POU2F1 0.025 0.012 -10000 0 -0.22 1 1
CDKN1A -0.035 0.28 -10000 0 -1.5 16 16
response to stress 0 0 -10000 0 -10000 0 0
response to UV -0.002 0.007 -10000 0 -10000 0 0
SFN -0.015 0.12 -10000 0 -0.45 37 37
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.064 0.16 0.3 60 -0.32 30 90
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 -0.086 0.33 0.5 2 -0.8 80 82
JUN -0.21 0.24 -10000 0 -0.51 161 161
IL4 -0.1 0.2 -10000 0 -0.61 38 38
CDK5R1 0.013 0.031 -10000 0 -0.25 7 7
PRKACA 0.018 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.22 0.28 0.21 47 -0.49 227 274
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.081 0.15 0.3 63 -0.3 19 82
cortisol/GR alpha (monomer) 0.28 0.32 0.63 183 -0.46 3 186
NCOA2 0.009 0.063 -10000 0 -0.4 11 11
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.18 0.21 -10000 0 -0.45 171 171
AP-1/NFAT1-c-4 -0.44 0.4 -10000 0 -0.79 249 249
AFP -0.16 0.2 -10000 0 -0.61 39 39
SUV420H1 0.014 0.037 -10000 0 -0.29 7 7
IRF1 0.11 0.25 0.46 44 -0.81 19 63
TP53 -0.015 0.17 -10000 0 -0.53 47 47
PPP5C 0.012 0.052 -10000 0 -0.39 8 8
KRT17 -0.53 0.58 -10000 0 -1.1 215 215
KRT14 -0.32 0.51 -10000 0 -1.4 94 94
TBP 0.028 0.012 -10000 0 -0.24 1 1
CREBBP 0.061 0.1 0.26 65 -0.53 2 67
HDAC1 0.011 0.025 -10000 0 -0.53 1 1
HDAC2 0.008 0.053 -10000 0 -0.29 15 15
AP-1 -0.44 0.4 -10000 0 -0.79 252 252
MAPK14 0.015 0.013 -10000 0 -0.25 1 1
MAPK10 -0.026 0.12 -10000 0 -0.36 58 58
MAPK11 0.016 0.008 -10000 0 -10000 0 0
KRT5 -0.54 0.58 -10000 0 -1.2 209 209
interleukin-1 receptor activity -0.001 0.009 -10000 0 -10000 0 0
NCOA1 0.013 0.059 -10000 0 -0.52 6 6
STAT1 -0.023 0.13 -10000 0 -0.34 67 67
CGA -0.12 0.2 -10000 0 -0.6 38 38
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.12 0.16 0.38 98 -0.39 2 100
MAPK3 0.014 0.027 -10000 0 -0.39 2 2
MAPK1 0.014 0.034 -10000 0 -0.52 2 2
ICAM1 -0.22 0.34 -10000 0 -0.84 84 84
NFKB1 -0.053 0.093 -10000 0 -0.3 14 14
MAPK8 -0.15 0.19 -10000 0 -0.42 128 128
MAPK9 -0.008 0.11 -10000 0 -0.51 24 24
cortisol/GR alpha (dimer) -0.014 0.18 0.5 6 -0.58 5 11
BAX 0.001 0.11 -10000 0 -10000 0 0
POMC -0.13 0.2 -10000 0 -1.3 5 5
EP300 0.059 0.11 0.26 65 -0.53 4 69
cortisol/GR alpha (dimer)/p53 0.21 0.28 0.54 166 -0.48 4 170
proteasomal ubiquitin-dependent protein catabolic process 0.07 0.08 0.21 78 -10000 0 78
SGK1 0.11 0.13 0.34 96 -0.26 4 100
IL13 -0.31 0.29 -10000 0 -0.71 128 128
IL6 -0.28 0.41 -10000 0 -0.9 123 123
PRKACG 0.016 0.033 -10000 0 -0.52 2 2
IL5 -0.26 0.24 -10000 0 -0.63 97 97
IL2 -0.32 0.33 -10000 0 -0.74 144 144
CDK5 0.015 0.027 -10000 0 -0.39 2 2
PRKACB -0.036 0.14 -10000 0 -0.34 79 79
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
IL8 -0.27 0.37 -10000 0 -0.82 122 122
CDK5R1/CDK5 0.02 0.03 -10000 0 -0.37 1 1
NF kappa B1 p50/RelA/PKAc -0.063 0.15 -10000 0 -0.38 47 47
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.23 0.24 0.52 170 -10000 0 170
SMARCA4 0.015 0.031 -10000 0 -0.32 4 4
chromatin remodeling 0.16 0.16 0.36 141 -0.33 1 142
NF kappa B1 p50/RelA/Cbp -0.018 0.16 0.34 6 -0.41 22 28
JUN (dimer) -0.21 0.24 -10000 0 -0.5 161 161
YWHAH 0.013 0.048 -10000 0 -0.47 5 5
VIPR1 -0.11 0.24 -10000 0 -0.69 53 53
NR3C1 0.16 0.21 0.43 137 -0.46 11 148
NR4A1 0.01 0.063 -10000 0 -0.44 4 4
TIF2/SUV420H1 0.017 0.055 -10000 0 -0.42 6 6
MAPKKK cascade -0.004 0.18 0.5 6 -0.55 5 11
cortisol/GR alpha (dimer)/Src-1 0.24 0.26 0.54 180 -0.43 3 183
PBX1 0.004 0.1 -10000 0 -0.48 23 23
POU1F1 0.023 0.033 -10000 0 -0.3 5 5
SELE -0.35 0.47 -10000 0 -0.94 174 174
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.16 0.16 0.36 140 -0.34 1 141
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.23 0.24 0.52 170 -10000 0 170
mol:cortisol 0.16 0.19 0.37 183 -10000 0 183
MMP1 -0.44 0.52 -10000 0 -1.3 132 132
TCR signaling in naïve CD8+ T cells

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.058 0.21 -10000 0 -0.45 97 97
FYN -0.085 0.26 -10000 0 -0.55 105 105
LAT/GRAP2/SLP76 -0.098 0.21 -10000 0 -0.47 110 110
IKBKB 0.012 0.047 -10000 0 -0.31 10 10
AKT1 -0.048 0.19 -10000 0 -0.37 112 112
B2M -0.005 0.1 -10000 0 -0.45 25 25
IKBKG 0.003 0.061 -10000 0 -0.13 48 48
MAP3K8 -0.036 0.15 -10000 0 -0.39 70 70
mol:Ca2+ -0.022 0.031 -10000 0 -0.083 66 66
integrin-mediated signaling pathway 0.007 0.068 -10000 0 -0.31 20 20
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.083 0.26 -10000 0 -0.54 111 111
TRPV6 -0.11 0.19 -10000 0 -0.38 159 159
CD28 -0.044 0.16 -10000 0 -0.4 78 78
SHC1 -0.09 0.26 -10000 0 -0.56 103 103
receptor internalization -0.12 0.3 -10000 0 -0.59 123 123
PRF1 -0.079 0.24 -10000 0 -0.7 45 45
KRAS 0.009 0.065 -10000 0 -0.44 10 10
GRB2 0.016 0.024 -10000 0 -0.25 4 4
COT/AKT1 -0.047 0.16 -10000 0 -0.32 107 107
LAT -0.095 0.27 -10000 0 -0.56 112 112
EntrezGene:6955 0 0.004 -10000 0 -10000 0 0
CD3D -0.029 0.13 -10000 0 -0.35 68 68
CD3E 0.016 0.018 -10000 0 -0.26 2 2
CD3G -0.092 0.2 -10000 0 -0.41 136 136
RASGRP2 -0.002 0.036 -10000 0 -0.11 27 27
RASGRP1 -0.061 0.2 -10000 0 -0.37 127 127
HLA-A -0.012 0.12 -10000 0 -0.43 34 34
RASSF5 -0.004 0.096 -10000 0 -0.38 29 29
RAP1A/GTP/RAPL 0.007 0.068 -10000 0 -0.31 20 20
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.004 0.064 -10000 0 -0.11 71 71
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.045 0.078 -10000 0 -0.2 87 87
PRKCA -0.043 0.1 -10000 0 -0.24 100 100
GRAP2 0.012 0.042 -10000 0 -0.28 10 10
mol:IP3 -0.051 0.18 0.18 83 -0.37 104 187
EntrezGene:6957 -0.001 0.005 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.08 0.22 -10000 0 -0.46 99 99
ORAI1 0.07 0.11 0.3 66 -0.38 1 67
CSK -0.088 0.26 -10000 0 -0.55 103 103
B7 family/CD28 -0.11 0.3 -10000 0 -0.61 114 114
CHUK 0.005 0.081 -10000 0 -0.5 13 13
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.11 0.3 -10000 0 -0.64 104 104
PTPN6 -0.094 0.26 -10000 0 -0.57 102 102
VAV1 -0.1 0.28 -10000 0 -0.59 107 107
Monovalent TCR/CD3 -0.096 0.22 -10000 0 -0.41 142 142
CBL 0.017 0.012 -10000 0 -0.25 1 1
LCK -0.097 0.28 -10000 0 -0.58 107 107
PAG1 -0.092 0.26 -10000 0 -0.56 104 104
RAP1A 0.012 0.057 -10000 0 -0.52 6 6
TCR/CD3/MHC I/CD8/LCK -0.12 0.3 -10000 0 -0.64 106 106
CD80 0.009 0.048 -10000 0 -0.27 14 14
CD86 -0.008 0.11 -10000 0 -0.5 26 26
PDK1/CARD11/BCL10/MALT1 -0.054 0.094 -10000 0 -0.24 92 92
HRAS 0.012 0.051 -10000 0 -0.41 7 7
GO:0035030 -0.091 0.24 -10000 0 -0.5 115 115
CD8A 0 0.005 -10000 0 -10000 0 0
CD8B 0.001 0.069 -10000 0 -0.28 29 29
PTPRC -0.041 0.16 -10000 0 -0.42 71 71
PDK1/PKC theta -0.06 0.23 -10000 0 -0.46 108 108
CSK/PAG1 -0.08 0.25 -10000 0 -0.54 99 99
SOS1 0.017 0.023 -10000 0 -0.52 1 1
peptide-MHC class I -0.01 0.13 -10000 0 -0.44 36 36
GRAP2/SLP76 -0.085 0.26 -10000 0 -0.55 106 106
STIM1 0.034 0.059 -10000 0 -0.53 1 1
RAS family/GTP -0.002 0.088 -10000 0 -0.17 70 70
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.13 0.33 -10000 0 -0.64 122 122
mol:DAG -0.072 0.14 0.13 1 -0.33 109 110
RAP1A/GDP 0.003 0.031 -10000 0 -0.077 21 21
PLCG1 0.016 0.026 -10000 0 -0.39 2 2
CD247 -0.11 0.21 -10000 0 -0.41 153 153
cytotoxic T cell degranulation -0.076 0.23 -10000 0 -0.66 45 45
RAP1A/GTP -0.005 0.014 -10000 0 -0.075 17 17
mol:PI-3-4-5-P3 -0.063 0.22 -10000 0 -0.44 111 111
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.076 0.23 0.21 77 -0.48 106 183
NRAS 0.005 0.076 -10000 0 -0.4 16 16
ZAP70 0.005 0.06 -10000 0 -0.27 24 24
GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
LAT/GRAP2/SLP76/VAV1 -0.1 0.21 0.16 1 -0.48 109 110
MALT1 0.011 0.053 -10000 0 -0.37 9 9
TRAF6 0.017 0.023 -10000 0 -0.52 1 1
CD8 heterodimer 0.002 0.049 -10000 0 -0.19 29 29
CARD11 0.002 0.077 -10000 0 -0.33 24 24
PRKCB -0.048 0.1 -10000 0 -0.23 109 109
PRKCE -0.045 0.11 -10000 0 -0.24 103 103
PRKCQ -0.078 0.26 -10000 0 -0.52 112 112
LCP2 -0.004 0.097 -10000 0 -0.4 27 27
BCL10 0.017 0.012 -10000 0 -0.25 1 1
regulation of survival gene product expression -0.037 0.16 -10000 0 -0.32 112 112
IKK complex 0.012 0.059 -10000 0 -0.1 59 59
RAS family/GDP -0.008 0.015 -10000 0 -0.064 20 20
MAP3K14 -0.029 0.12 -10000 0 -0.25 91 91
PDPK1 -0.042 0.18 -10000 0 -0.36 104 104
TCR/CD3/MHC I/CD8/Fyn -0.091 0.26 -10000 0 -0.59 91 91
IL12-mediated signaling events

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.029 0.12 -10000 0 -0.36 29 29
TBX21 -0.3 0.59 -10000 0 -1.3 123 123
B2M -0.005 0.1 -10000 0 -0.45 25 25
TYK2 0.012 0.022 -10000 0 -10000 0 0
IL12RB1 0.012 0.022 -10000 0 -10000 0 0
GADD45B -0.18 0.44 -10000 0 -1 96 96
IL12RB2 -0.076 0.16 -10000 0 -0.32 142 142
GADD45G -0.18 0.43 -10000 0 -1 90 90
natural killer cell activation -0.005 0.024 -10000 0 -10000 0 0
RELB 0.003 0.078 -10000 0 -0.38 19 19
RELA 0.018 0 -10000 0 -10000 0 0
IL18 -0.046 0.17 -10000 0 -0.44 76 76
IL2RA -0.03 0.14 -10000 0 -0.4 60 60
IFNG -0.088 0.17 -10000 0 -0.33 161 161
STAT3 (dimer) -0.14 0.37 -10000 0 -0.76 112 112
HLA-DRB5 -0.002 0.093 -10000 0 -0.51 17 17
FASLG -0.24 0.52 -10000 0 -1.1 114 114
NF kappa B2 p52/RelB -0.24 0.41 -10000 0 -0.86 131 131
CD4 0.015 0.007 -10000 0 -10000 0 0
SOCS1 0.015 0.031 -10000 0 -0.32 4 4
EntrezGene:6955 -0.005 0.012 -10000 0 -10000 0 0
CD3D -0.033 0.13 -10000 0 -0.35 68 68
CD3E 0.013 0.021 -10000 0 -0.28 2 2
CD3G -0.097 0.2 -10000 0 -0.42 136 136
IL12Rbeta2/JAK2 -0.048 0.13 -10000 0 -0.33 59 59
CCL3 -0.2 0.44 -10000 0 -0.98 101 101
CCL4 -0.2 0.46 -10000 0 -0.98 110 110
HLA-A -0.012 0.11 -10000 0 -0.43 34 34
IL18/IL18R -0.056 0.21 -10000 0 -0.41 117 117
NOS2 -0.19 0.44 -10000 0 -0.82 135 135
IL12/IL12R/TYK2/JAK2/SPHK2 -0.029 0.12 -10000 0 -0.35 31 31
IL1R1 -0.25 0.51 -10000 0 -1.1 127 127
IL4 0.016 0.063 -10000 0 -0.48 7 7
JAK2 0.004 0.06 -10000 0 -0.34 12 12
EntrezGene:6957 -0.004 0.011 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.13 0.33 -10000 0 -0.66 103 103
RAB7A -0.12 0.34 -10000 0 -0.79 87 87
lysosomal transport -0.12 0.33 -10000 0 -0.74 88 88
FOS -0.29 0.5 -10000 0 -1 135 135
STAT4 (dimer) -0.18 0.43 -10000 0 -0.87 120 120
STAT5A (dimer) -0.27 0.42 -10000 0 -0.88 138 138
GZMA -0.2 0.43 -10000 0 -0.85 131 131
GZMB -0.28 0.57 -10000 0 -1.2 128 128
HLX 0.005 0.079 -10000 0 -0.48 13 13
LCK -0.25 0.52 -10000 0 -0.98 141 141
TCR/CD3/MHC II/CD4 -0.11 0.23 -10000 0 -0.49 107 107
IL2/IL2R -0.014 0.14 -10000 0 -0.33 71 71
MAPK14 -0.18 0.44 -10000 0 -0.94 105 105
CCR5 -0.19 0.46 -10000 0 -0.98 105 105
IL1B -0.053 0.17 -10000 0 -0.42 81 81
STAT6 -0.066 0.18 -10000 0 -0.37 77 77
STAT4 -0.024 0.13 -10000 0 -0.42 50 50
STAT3 0.015 0.04 -10000 0 -0.52 3 3
STAT1 -0.02 0.12 -10000 0 -0.33 58 58
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
NFKB2 0.015 0.031 -10000 0 -0.32 4 4
IL12B 0 0.077 -10000 0 -0.34 21 21
CD8A -0.001 0.008 -10000 0 -10000 0 0
CD8B 0.001 0.07 -10000 0 -0.28 29 29
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.029 0.12 0.35 29 -10000 0 29
IL2RB -0.016 0.12 -10000 0 -0.43 40 40
proteasomal ubiquitin-dependent protein catabolic process -0.16 0.38 -10000 0 -0.78 120 120
IL2RG -0.002 0.078 -10000 0 -0.28 35 35
IL12 -0.011 0.089 -10000 0 -0.32 19 19
STAT5A 0.011 0.056 -10000 0 -0.42 8 8
CD247 -0.11 0.21 -10000 0 -0.42 153 153
IL2 0.011 0.051 -10000 0 -0.33 10 10
SPHK2 0.017 0.023 -10000 0 -0.52 1 1
FRAP1 0.018 0 -10000 0 -10000 0 0
IL12A -0.019 0.095 -10000 0 -0.28 55 55
IL12/IL12R/TYK2/JAK2 -0.25 0.54 -10000 0 -1 131 131
MAP2K3 -0.18 0.44 -10000 0 -0.94 108 108
RIPK2 0.013 0.04 -10000 0 -0.28 9 9
MAP2K6 -0.19 0.45 -10000 0 -0.95 110 110
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA 0.002 0.08 -10000 0 -0.52 12 12
IL18RAP -0.071 0.19 -10000 0 -0.4 114 114
IL12Rbeta1/TYK2 0.018 0.032 -10000 0 -10000 0 0
EOMES -0.059 0.26 -10000 0 -1.3 21 21
STAT1 (dimer) -0.2 0.39 -10000 0 -0.78 129 129
T cell proliferation -0.12 0.31 -10000 0 -0.63 117 117
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 -0.01 0.12 -10000 0 -0.41 37 37
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.2 0.3 -10000 0 -0.69 120 120
ATF2 -0.15 0.4 -10000 0 -0.85 103 103
Noncanonical Wnt signaling pathway

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 0.013 0.048 -9999 0 -0.47 5 5
GNB1/GNG2 -0.11 0.19 -9999 0 -0.42 103 103
mol:DAG -0.093 0.18 -9999 0 -0.44 72 72
PLCG1 -0.096 0.18 -9999 0 -0.46 72 72
YES1 -0.12 0.2 -9999 0 -0.45 104 104
FZD3 -0.03 0.15 -9999 0 -0.48 51 51
FZD6 -0.077 0.2 -9999 0 -0.45 108 108
G protein -0.099 0.19 -9999 0 -0.46 76 76
MAP3K7 -0.068 0.15 -9999 0 -0.39 61 61
mol:Ca2+ -0.09 0.17 -9999 0 -0.43 72 72
mol:IP3 -0.093 0.18 -9999 0 -0.44 72 72
NLK 0.016 0.044 -9999 0 -0.9 1 1
GNB1 0.013 0.052 -9999 0 -0.52 5 5
CAMK2A -0.079 0.16 -9999 0 -0.42 61 61
MAP3K7IP1 0.018 0 -9999 0 -10000 0 0
Noncanonical Wnts/FZD -0.13 0.21 -9999 0 -0.46 102 102
CSNK1A1 0.017 0.023 -9999 0 -0.52 1 1
GNAS -0.12 0.2 -9999 0 -0.44 104 104
GO:0007205 -0.092 0.17 -9999 0 -0.43 73 73
WNT6 -0.011 0.087 -9999 0 -0.26 54 54
WNT4 -0.062 0.18 -9999 0 -0.45 90 90
NFAT1/CK1 alpha -0.091 0.19 -9999 0 -0.48 65 65
GNG2 0.016 0.029 -9999 0 -0.34 3 3
WNT5A -0.084 0.2 -9999 0 -0.43 120 120
WNT11 -0.013 0.089 -9999 0 -0.26 57 57
CDC42 -0.11 0.2 -9999 0 -0.42 104 104
Osteopontin-mediated events

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.062 0.17 -9999 0 -0.44 50 50
NF kappa B1 p50/RelA/I kappa B alpha -0.043 0.18 -9999 0 -0.5 41 41
alphaV/beta3 Integrin/Osteopontin/Src -0.098 0.18 -9999 0 -0.39 131 131
AP1 -0.15 0.26 -9999 0 -0.58 105 105
ILK -0.064 0.16 -9999 0 -0.42 44 44
bone resorption -0.055 0.17 -9999 0 -0.44 44 44
PTK2B 0.017 0.017 -9999 0 -0.25 2 2
PYK2/p130Cas -0.059 0.17 -9999 0 -0.41 54 54
ITGAV -0.001 0.1 -9999 0 -0.49 21 21
mol:GTP 0 0 -9999 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.007 0.081 -9999 0 -0.37 21 21
alphaV/beta3 Integrin/Osteopontin -0.076 0.18 -9999 0 -0.34 142 142
MAP3K1 -0.09 0.18 -9999 0 -0.32 166 166
JUN -0.034 0.15 -9999 0 -0.46 57 57
MAPK3 -0.064 0.17 -9999 0 -0.47 46 46
MAPK1 -0.064 0.17 -9999 0 -0.47 47 47
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
NFKB1 0.017 0.023 -9999 0 -0.52 1 1
MAPK8 -0.08 0.17 -9999 0 -0.41 67 67
ITGB3 0.003 0.077 -9999 0 -0.32 25 25
NFKBIA -0.063 0.19 -9999 0 -0.52 48 48
FOS -0.11 0.2 -9999 0 -0.37 171 171
CD44 -0.004 0.1 -9999 0 -0.43 26 26
CHUK 0.005 0.081 -9999 0 -0.5 13 13
PLAU -0.14 0.38 -9999 0 -1.2 54 54
NF kappa B1 p50/RelA -0.047 0.19 -9999 0 -0.52 45 45
BCAR1 0.017 0.012 -9999 0 -0.25 1 1
RELA 0.018 0 -9999 0 -10000 0 0
alphaV beta3 Integrin 0.003 0.1 -9999 0 -0.42 22 22
mol:GDP 0 0 -9999 0 -10000 0 0
SYK -0.085 0.18 -9999 0 -0.32 162 162
VAV3 -0.12 0.2 -9999 0 -0.43 100 100
MAP3K14 -0.069 0.17 -9999 0 -0.31 137 137
ROCK2 0.013 0.048 -9999 0 -0.47 5 5
SPP1 -0.14 0.23 -9999 0 -0.42 188 188
RAC1 0.018 0 -9999 0 -10000 0 0
Rac1/GTP -0.11 0.18 -9999 0 -0.4 97 97
MMP2 -0.13 0.24 -9999 0 -0.55 101 101
IL23-mediated signaling events

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.23 0.53 -10000 0 -1.3 86 86
IL23A -0.21 0.49 -10000 0 -1.2 68 68
NF kappa B1 p50/RelA/I kappa B alpha -0.22 0.42 -10000 0 -1 88 88
positive regulation of T cell mediated cytotoxicity -0.21 0.51 -10000 0 -1.1 91 91
ITGA3 -0.2 0.48 -10000 0 -1.1 80 80
IL17F -0.097 0.32 -10000 0 -0.68 76 76
IL12B 0.004 0.084 -10000 0 -0.35 21 21
STAT1 (dimer) -0.21 0.49 -10000 0 -1.1 93 93
CD4 -0.17 0.44 -10000 0 -1 76 76
IL23 -0.2 0.47 -10000 0 -1.2 69 69
IL23R -0.011 0.18 -10000 0 -1.4 7 7
IL1B -0.23 0.53 -10000 0 -1.3 80 80
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.18 0.44 -10000 0 -1 74 74
TYK2 0.013 0.024 -10000 0 -10000 0 0
STAT4 -0.024 0.13 -10000 0 -0.42 50 50
STAT3 0.015 0.041 -10000 0 -0.52 3 3
IL18RAP -0.075 0.18 -10000 0 -0.41 114 114
IL12RB1 0.013 0.024 -10000 0 -10000 0 0
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
IL12Rbeta1/TYK2 0.017 0.031 -10000 0 -10000 0 0
IL23R/JAK2 -0.013 0.19 -10000 0 -1 10 10
positive regulation of chronic inflammatory response -0.21 0.51 -10000 0 -1.1 91 91
natural killer cell activation 0.001 0.012 0.073 8 -10000 0 8
JAK2 0.011 0.065 -10000 0 -0.34 12 12
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
NFKB1 0.016 0.024 -10000 0 -0.52 1 1
RELA 0.017 0.004 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.19 0.45 -10000 0 -1.1 69 69
ALOX12B -0.17 0.44 -10000 0 -1.1 69 69
CXCL1 -0.27 0.54 -10000 0 -1.1 116 116
T cell proliferation -0.21 0.51 -10000 0 -1.1 91 91
NFKBIA 0.014 0.043 -10000 0 -0.46 4 4
IL17A -0.052 0.26 -10000 0 -0.55 55 55
PI3K -0.19 0.47 -10000 0 -1.1 88 88
IFNG -0.027 0.05 0.12 2 -0.12 59 61
STAT3 (dimer) -0.21 0.41 -10000 0 -0.98 92 92
IL18R1 -0.014 0.11 -10000 0 -0.41 37 37
IL23/IL23R/JAK2/TYK2/SOCS3 -0.08 0.28 -10000 0 -0.6 62 62
IL18/IL18R -0.082 0.2 -10000 0 -0.41 117 117
macrophage activation -0.015 0.017 -10000 0 -0.044 64 64
TNF -0.2 0.49 -10000 0 -1.2 76 76
STAT3/STAT4 -0.24 0.45 -10000 0 -1 97 97
STAT4 (dimer) -0.21 0.5 -10000 0 -1.1 96 96
IL18 -0.05 0.17 -10000 0 -0.44 76 76
IL19 -0.19 0.44 -10000 0 -1.1 70 70
STAT5A (dimer) -0.2 0.49 -10000 0 -1.1 92 92
STAT1 -0.02 0.12 -10000 0 -0.33 58 58
SOCS3 0.005 0.074 -10000 0 -0.38 17 17
CXCL9 -0.27 0.57 -10000 0 -1.2 122 122
MPO -0.17 0.44 -10000 0 -1.1 68 68
positive regulation of humoral immune response -0.21 0.51 -10000 0 -1.1 91 91
IL23/IL23R/JAK2/TYK2 -0.22 0.54 -10000 0 -1.2 91 91
IL6 -0.26 0.55 -10000 0 -1.2 100 100
STAT5A 0.011 0.056 -10000 0 -0.42 8 8
IL2 0.008 0.053 -10000 0 -0.34 10 10
positive regulation of tyrosine phosphorylation of STAT protein 0.001 0.012 0.073 8 -10000 0 8
CD3E -0.17 0.44 -10000 0 -1 68 68
keratinocyte proliferation -0.21 0.51 -10000 0 -1.1 91 91
NOS2 -0.18 0.44 -10000 0 -0.96 91 91
Arf6 signaling events

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0 0.058 -10000 0 -0.26 23 23
ARNO/beta Arrestin1-2 -0.013 0.089 -10000 0 -0.24 57 57
EGFR -0.079 0.18 -10000 0 -0.35 139 139
EPHA2 0.008 0.059 -10000 0 -0.33 14 14
USP6 0.012 0.04 -10000 0 -0.25 12 12
IQSEC1 0.016 0.026 -10000 0 -0.39 2 2
EGFR/EGFR/EGF/EGF -0.15 0.2 -10000 0 -0.42 173 173
ARRB2 0.011 0.052 -10000 0 -0.32 12 12
mol:GTP 0.006 0.015 0.063 11 -0.092 5 16
ARRB1 0.004 0.075 -10000 0 -0.37 18 18
FBXO8 0.015 0.04 -10000 0 -0.52 3 3
TSHR 0.008 0.071 -10000 0 -0.5 10 10
EGF -0.14 0.23 -10000 0 -0.42 193 193
somatostatin receptor activity 0 0 -10000 0 -0.001 95 95
ARAP2 0 0 -10000 0 0 108 108
mol:GDP -0.054 0.11 -10000 0 -0.25 89 89
mol:PI-3-4-5-P3 0 0 -10000 0 -0.001 96 96
ITGA2B 0.016 0.02 -10000 0 -0.25 3 3
ARF6 0.016 0.033 -10000 0 -0.52 2 2
Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.071 -10000 0 -0.27 24 24
ADAP1 0 0 -10000 0 0 87 87
KIF13B -0.002 0.095 -10000 0 -0.43 23 23
HGF/MET 0.007 0.073 -10000 0 -0.38 13 13
PXN 0.018 0 -10000 0 -10000 0 0
ARF6/GTP -0.067 0.11 -10000 0 -0.27 93 93
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.12 0.18 -10000 0 -0.35 173 173
ADRB2 -0.045 0.16 -10000 0 -0.4 80 80
receptor agonist activity 0 0 -10000 0 0 92 92
actin filament binding 0 0 -10000 0 0 96 96
SRC 0.015 0.035 -10000 0 -0.43 3 3
ITGB3 0.002 0.075 -10000 0 -0.32 25 25
GNAQ 0 0 -10000 0 -0.001 88 88
EFA6/PI-4-5-P2 0 0 -10000 0 -0.001 90 90
ARF6/GDP -0.003 0.059 -10000 0 -0.3 5 5
ARF6/GDP/GULP/ACAP1 -0.058 0.13 -10000 0 -0.33 74 74
alphaIIb/beta3 Integrin/paxillin/GIT1 0.034 0.048 -10000 0 -0.26 8 8
ACAP1 0 0 -10000 0 0 18 18
ACAP2 0 0 -10000 0 0 104 104
LHCGR/beta Arrestin2 0.009 0.07 -10000 0 -0.44 12 12
EFNA1 0 0.094 -10000 0 -0.49 18 18
HGF 0.008 0.069 -10000 0 -0.45 11 11
CYTH3 0 0 -10000 0 -0.001 94 94
CYTH2 -0.001 0.002 -10000 0 -0.004 100 100
NCK1 0.011 0.045 -10000 0 -0.28 12 12
fibronectin binding 0 0 -10000 0 0 75 75
endosomal lumen acidification 0 0 -10000 0 0 83 83
microtubule-based process 0 0 -10000 0 -10000 0 0
GULP1 -0.035 0.15 -10000 0 -0.44 61 61
GNAQ/ARNO -0.001 0.003 -10000 0 -0.006 89 89
mol:Phosphatidic acid 0 0 -10000 0 0 104 104
PIP3-E 0.004 0.068 -10000 0 -0.3 23 23
MET 0 0.075 -10000 0 -0.29 31 31
GNA14 -0.08 0.18 -10000 0 -0.35 140 140
GNA15 0.002 0.076 -10000 0 -0.34 23 23
GIT1 0.014 0.035 -10000 0 -0.3 6 6
mol:PI-4-5-P2 0 0 -10000 0 -0.001 92 92
GNA11 0.013 0.047 -10000 0 -0.52 4 4
LHCGR 0.003 0.083 -10000 0 -0.46 16 16
AGTR1 -0.15 0.21 -10000 0 -0.36 231 231
desensitization of G-protein coupled receptor protein signaling pathway 0.009 0.07 -10000 0 -0.44 12 12
IPCEF1/ARNO -0.095 0.14 -10000 0 -0.28 179 179
alphaIIb/beta3 Integrin 0.014 0.056 -10000 0 -0.36 7 7
Thromboxane A2 receptor signaling

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.015 0.12 -10000 0 -0.38 44 44
GNB1/GNG2 -0.058 0.078 -10000 0 -0.18 138 138
AKT1 -0.023 0.12 -10000 0 -0.21 79 79
EGF -0.14 0.23 -10000 0 -0.42 193 193
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR 0.03 0.061 -10000 0 -0.29 5 5
mol:Ca2+ -0.048 0.17 -10000 0 -0.29 141 141
LYN 0.029 0.062 -10000 0 -0.29 5 5
RhoA/GTP -0.041 0.056 -10000 0 -0.13 82 82
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.066 0.19 -10000 0 -0.35 142 142
GNG2 0.016 0.029 -10000 0 -0.34 3 3
ARRB2 0.018 0 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.004 0.1 -10000 0 -0.39 22 22
G beta5/gamma2 -0.075 0.1 -10000 0 -0.24 137 137
PRKCH -0.062 0.19 -10000 0 -0.35 139 139
DNM1 0.013 0.047 -10000 0 -0.37 7 7
TXA2/TP beta/beta Arrestin3 0.006 0.019 -10000 0 -0.21 2 2
mol:GTP 0 0.002 -10000 0 -10000 0 0
PTGDR -0.002 0.088 -10000 0 -0.35 29 29
G12 family/GTP -0.096 0.13 -10000 0 -0.3 141 141
ADRBK1 0.018 0 -10000 0 -10000 0 0
ADRBK2 0.002 0.088 -10000 0 -0.49 16 16
RhoA/GTP/ROCK1 0.016 0.05 -10000 0 -0.31 12 12
mol:GDP 0.019 0.12 0.35 19 -10000 0 19
mol:NADP 0.017 0.012 -10000 0 -0.25 1 1
RAB11A 0.016 0.029 -10000 0 -0.34 3 3
PRKG1 0.017 0.012 -10000 0 -0.25 1 1
mol:IP3 -0.067 0.2 -10000 0 -0.37 141 141
cell morphogenesis 0.016 0.05 -10000 0 -0.31 12 12
PLCB2 -0.1 0.26 -10000 0 -0.5 141 141
mol:cGMP 0 0.001 -10000 0 -10000 0 0
BLK 0.016 0.073 -10000 0 -0.31 6 6
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK 0.02 0.085 -10000 0 -0.38 12 12
RHOA 0.005 0.08 -10000 0 -0.52 12 12
PTGIR 0.016 0.033 -10000 0 -0.52 2 2
PRKCB1 -0.081 0.22 -10000 0 -0.4 142 142
GNAQ 0 0 -10000 0 -10000 0 0
mol:L-citrulline 0.017 0.012 -10000 0 -0.25 1 1
TXA2/TXA2-R family -0.11 0.27 -10000 0 -0.52 140 140
LCK -0.008 0.11 -10000 0 -0.37 16 16
TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.034 0.044 -10000 0 -0.36 2 2
TXA2-R family/G12 family/GDP/G beta/gamma 0.029 0.059 -10000 0 -0.53 5 5
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.034 0.044 -10000 0 -0.36 2 2
MAPK14 -0.033 0.13 -10000 0 -0.23 137 137
TGM2/GTP -0.079 0.23 -10000 0 -0.41 147 147
MAPK11 -0.033 0.13 -10000 0 -0.23 137 137
ARHGEF1 -0.021 0.1 -10000 0 -0.17 136 136
GNAI2 0.006 0.075 -10000 0 -0.48 12 12
JNK cascade -0.069 0.21 -10000 0 -0.38 140 140
RAB11/GDP 0.016 0.028 -10000 0 -0.34 3 3
ICAM1 -0.052 0.17 -10000 0 -0.3 139 139
cAMP biosynthetic process -0.063 0.19 -10000 0 -0.34 139 139
Gq family/GTP/EBP50 -0.038 0.11 -10000 0 -0.25 94 94
actin cytoskeleton reorganization 0.016 0.05 -10000 0 -0.31 12 12
SRC 0.029 0.062 -10000 0 -0.29 5 5
GNB5 0.005 0.081 -10000 0 -0.5 13 13
GNB1 0.013 0.052 -10000 0 -0.52 5 5
EGF/EGFR -0.028 0.11 -10000 0 -0.29 44 44
VCAM1 -0.054 0.17 -10000 0 -0.31 144 144
TP beta/Gq family/GDP/G beta5/gamma2 -0.004 0.1 -10000 0 -0.39 22 22
platelet activation -0.042 0.17 -10000 0 -0.3 139 139
PGI2/IP 0.012 0.024 -10000 0 -0.38 2 2
PRKACA 0.015 0.046 -10000 0 -0.26 12 12
Gq family/GDP/G beta5/gamma2 -0.005 0.096 -10000 0 -0.36 22 22
TXA2/TP beta/beta Arrestin2 -0.005 0.044 -10000 0 -0.56 3 3
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R 0.021 0.044 -10000 0 -0.24 12 12
mol:DAG -0.079 0.22 -10000 0 -0.41 140 140
EGFR -0.079 0.18 -10000 0 -0.35 139 139
TXA2/TP alpha -0.09 0.25 -10000 0 -0.46 139 139
Gq family/GTP -0.038 0.078 -10000 0 -0.24 58 58
YES1 0.026 0.07 -10000 0 -0.34 6 6
GNAI2/GTP -0.015 0.055 -10000 0 -0.33 5 5
PGD2/DP -0.001 0.062 -10000 0 -0.24 29 29
SLC9A3R1 -0.043 0.16 -10000 0 -0.44 70 70
FYN 0.026 0.073 -10000 0 -0.33 10 10
mol:NO 0.017 0.012 -10000 0 -0.25 1 1
GNA15 0.002 0.076 -10000 0 -0.34 23 23
PGK/cGMP 0.023 0.01 -10000 0 -10000 0 0
RhoA/GDP 0.006 0.079 -10000 0 -0.51 12 12
TP alpha/TGM2/GDP/G beta/gamma 0.028 0.078 -10000 0 -0.37 7 7
NOS3 0.017 0.012 -10000 0 -0.26 1 1
RAC1 0.018 0 -10000 0 -10000 0 0
PRKCA -0.061 0.19 -10000 0 -0.34 140 140
PRKCB -0.064 0.19 -10000 0 -0.35 141 141
PRKCE -0.062 0.19 -10000 0 -0.35 139 139
PRKCD -0.068 0.2 -10000 0 -0.37 139 139
PRKCG -0.069 0.2 -10000 0 -0.37 140 140
muscle contraction -0.095 0.25 -10000 0 -0.48 140 140
PRKCZ -0.06 0.18 -10000 0 -0.34 140 140
ARR3 0.017 0.012 -10000 0 -0.25 1 1
TXA2/TP beta 0.028 0.059 -10000 0 -0.25 8 8
PRKCQ -0.068 0.2 -10000 0 -0.35 145 145
MAPKKK cascade -0.086 0.23 -10000 0 -0.44 141 141
SELE -0.077 0.2 -10000 0 -0.38 144 144
TP beta/GNAI2/GDP/G beta/gamma 0.038 0.068 -10000 0 -0.37 7 7
ROCK1 0.018 0 -10000 0 -10000 0 0
GNA14 -0.079 0.18 -10000 0 -0.35 140 140
chemotaxis -0.13 0.31 -10000 0 -0.61 138 138
GNA12 0.018 0 -10000 0 -10000 0 0
GNA13 0.011 0.055 -10000 0 -0.36 10 10
GNA11 0.014 0.047 -10000 0 -0.52 4 4
Rac1/GTP 0.013 0.002 -10000 0 -10000 0 0
Nongenotropic Androgen signaling

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.011 0.02 -10000 0 -0.24 3 3
GNB1/GNG2 -0.031 0.13 -10000 0 -0.28 107 107
regulation of S phase of mitotic cell cycle -0.031 0.12 -10000 0 -0.24 120 120
GNAO1 0.016 0.024 -10000 0 -0.25 4 4
HRAS 0.011 0.051 -10000 0 -0.41 7 7
SHBG/T-DHT 0.012 0 -10000 0 -10000 0 0
PELP1 0.017 0.001 -10000 0 -10000 0 0
AKT1 0.008 0.038 -10000 0 -0.26 9 9
MAP2K1 -0.032 0.12 -10000 0 -0.32 32 32
T-DHT/AR -0.064 0.16 -10000 0 -0.38 104 104
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP -0.001 0.003 -10000 0 -0.005 166 166
GNAI2 0.006 0.075 -10000 0 -0.48 12 12
GNAI3 0.018 0 -10000 0 -10000 0 0
GNAI1 -0.017 0.12 -10000 0 -0.38 46 46
mol:GDP -0.089 0.17 -10000 0 -0.43 103 103
cell proliferation -0.066 0.18 -10000 0 -0.4 83 83
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
FOS -0.13 0.3 -10000 0 -0.78 81 81
mol:Ca2+ -0.014 0.022 -10000 0 -0.06 69 69
MAPK3 -0.05 0.14 -10000 0 -0.42 33 33
MAPK1 -0.029 0.092 -10000 0 -0.27 26 26
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
mol:IP3 -0.001 0.002 -10000 0 -0.003 171 171
cAMP biosynthetic process 0.013 0.021 -10000 0 -10000 0 0
GNG2 0.016 0.029 -10000 0 -0.34 3 3
potassium channel inhibitor activity -0.001 0.002 -10000 0 -0.003 171 171
HRAS/GTP -0.036 0.12 -10000 0 -0.26 107 107
actin cytoskeleton reorganization -0.01 0.049 -10000 0 -0.24 21 21
SRC 0.015 0.035 -10000 0 -0.43 3 3
voltage-gated calcium channel activity -0.001 0.002 -10000 0 -0.003 171 171
PI3K 0.006 0.07 -10000 0 -0.31 21 21
apoptosis 0.064 0.17 0.41 82 -10000 0 82
T-DHT/AR/PELP1 -0.044 0.13 -10000 0 -0.32 103 103
HRAS/GDP -0.063 0.18 -10000 0 -0.4 105 105
CREB1 -0.069 0.18 -10000 0 -0.44 82 82
RAC1-CDC42/GTP 0.02 0.057 -10000 0 -0.24 21 21
AR -0.089 0.21 -10000 0 -0.52 104 104
GNB1 0.013 0.052 -10000 0 -0.52 5 5
RAF1 -0.033 0.12 -10000 0 -0.25 107 107
RAC1-CDC42/GDP -0.047 0.17 -10000 0 -0.38 103 103
T-DHT/AR/PELP1/Src -0.032 0.12 -10000 0 -0.28 105 105
MAP2K2 -0.033 0.12 -10000 0 -0.33 32 32
T-DHT/AR/PELP1/Src/PI3K -0.032 0.12 -10000 0 -0.24 120 120
GNAZ 0.001 0.088 -10000 0 -0.44 19 19
SHBG 0.018 0 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP 0.002 0.1 -10000 0 -0.44 15 15
mol:T-DHT 0 0.001 0.002 1 -0.003 52 53
RAC1 0.018 0 -10000 0 -10000 0 0
GNRH1 0 0.057 -10000 0 -0.23 26 26
Gi family/GTP -0.022 0.092 -10000 0 -0.28 21 21
CDC42 0.018 0 -10000 0 -10000 0 0
PLK2 and PLK4 events

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 -0.049 0.17 -9999 0 -0.44 77 77
PLK4 0.008 0.065 -9999 0 -0.38 13 13
regulation of centriole replication -0.029 0.13 -9999 0 -0.37 59 59
Stabilization and expansion of the E-cadherin adherens junction

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization -0.027 0.13 -10000 0 -0.26 110 110
epithelial cell differentiation -0.007 0.1 -10000 0 -0.26 76 76
CYFIP2 -0.042 0.16 -10000 0 -0.47 65 65
ENAH 0.012 0.096 -10000 0 -0.31 14 14
EGFR -0.079 0.18 -10000 0 -0.35 139 139
EPHA2 0.008 0.059 -10000 0 -0.33 14 14
MYO6 -0.012 0.11 -10000 0 -0.25 90 90
CTNNB1 0.001 0.09 -10000 0 -0.45 19 19
ABI1/Sra1/Nap1 -0.004 0.11 -10000 0 -0.31 53 53
AQP5 -0.086 0.19 -10000 0 -0.44 97 97
CTNND1 0.016 0.029 -10000 0 -0.34 3 3
mol:PI-4-5-P2 -0.004 0.1 -10000 0 -0.24 78 78
regulation of calcium-dependent cell-cell adhesion -0.014 0.1 -10000 0 -0.24 82 82
EGF -0.14 0.23 -10000 0 -0.42 193 193
NCKAP1 0.015 0.031 -10000 0 -0.32 4 4
AQP3 -0.088 0.2 -10000 0 -0.49 86 86
cortical microtubule organization -0.007 0.1 -10000 0 -0.26 76 76
GO:0000145 -0.006 0.095 -10000 0 -0.23 78 78
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.11 -10000 0 -0.26 76 76
MLLT4 -0.006 0.11 -10000 0 -0.46 26 26
ARF6/GDP -0.04 0.086 -10000 0 -0.39 12 12
ARF6 0.016 0.033 -10000 0 -0.52 2 2
Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.071 -10000 0 -0.27 24 24
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.006 0.12 -10000 0 -0.44 15 15
PVRL2 0.002 0.089 -10000 0 -0.52 15 15
ZYX -0.009 0.11 -10000 0 -0.24 84 84
ARF6/GTP 0.03 0.072 -10000 0 -0.27 22 22
CDH1 -0.049 0.17 -10000 0 -0.48 70 70
EGFR/EGFR/EGF/EGF -0.14 0.14 -10000 0 -0.38 92 92
RhoA/GDP -0.01 0.11 -10000 0 -0.25 85 85
actin cytoskeleton organization -0.007 0.11 -10000 0 -0.38 8 8
IGF-1R heterotetramer -0.083 0.2 -10000 0 -0.47 110 110
GIT1 0.014 0.035 -10000 0 -0.3 6 6
IGF1R -0.083 0.2 -10000 0 -0.47 110 110
IGF1 -0.1 0.2 -10000 0 -0.41 146 146
DIAPH1 -0.055 0.18 -10000 0 -0.58 53 53
Wnt receptor signaling pathway 0.007 0.1 0.26 76 -10000 0 76
RHOA 0.005 0.08 -10000 0 -0.52 12 12
RhoA/GTP -0.044 0.089 -10000 0 -0.37 16 16
CTNNA1 0.017 0.023 -10000 0 -0.52 1 1
VCL -0.007 0.11 -10000 0 -0.39 8 8
EFNA1 0 0.094 -10000 0 -0.49 18 18
LPP -0.003 0.1 -10000 0 -0.38 8 8
Ephrin A1/EPHA2 -0.044 0.094 -10000 0 -0.43 8 8
SEC6/SEC8 -0.045 0.092 -10000 0 -0.41 10 10
MGAT3 -0.014 0.11 -10000 0 -0.25 82 82
HGF/MET -0.044 0.089 -10000 0 -0.34 10 10
HGF 0.008 0.069 -10000 0 -0.45 11 11
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.13 -10000 0 -0.26 110 110
actin cable formation 0.017 0.1 -10000 0 -0.28 21 21
KIAA1543 0.001 0.1 -10000 0 -0.36 10 10
KIFC3 -0.005 0.1 -10000 0 -0.24 77 77
NCK1 0.011 0.045 -10000 0 -0.28 12 12
EXOC3 0.017 0.012 -10000 0 -0.25 1 1
ACTN1 -0.009 0.11 -10000 0 -0.24 85 85
NCK1/GIT1 0.019 0.042 -10000 0 -0.44 2 2
mol:GDP -0.007 0.1 -10000 0 -0.26 76 76
EXOC4 0.016 0.033 -10000 0 -0.52 2 2
STX4 -0.003 0.1 -10000 0 -0.24 76 76
PIP5K1C -0.004 0.1 -10000 0 -0.24 78 78
LIMA1 -0.024 0.14 -10000 0 -0.52 41 41
ABI1 0.016 0.02 -10000 0 -0.25 3 3
ROCK1 0.009 0.1 -10000 0 -0.36 10 10
adherens junction assembly 0.012 0.11 -10000 0 -0.44 8 8
IGF-1R heterotetramer/IGF1 -0.12 0.16 -10000 0 -0.31 166 166
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.1 -10000 0 -0.39 33 33
MET 0 0.075 -10000 0 -0.29 31 31
PLEKHA7 -0.003 0.099 -10000 0 -0.24 77 77
mol:GTP 0.024 0.07 -10000 0 -0.27 24 24
establishment of epithelial cell apical/basal polarity 0.006 0.11 -10000 0 -0.41 10 10
cortical actin cytoskeleton stabilization -0.027 0.13 -10000 0 -0.26 110 110
regulation of cell-cell adhesion -0.007 0.11 -10000 0 -0.38 8 8
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.13 -10000 0 -0.26 110 110
E-cadherin signaling events

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin -0.02 0.13 -9999 0 -0.32 78 78
E-cadherin/beta catenin -0.034 0.14 -9999 0 -0.38 74 74
CTNNB1 0.001 0.09 -9999 0 -0.45 19 19
JUP 0.011 0.056 -9999 0 -0.42 8 8
CDH1 -0.049 0.17 -9999 0 -0.48 70 70
Syndecan-4-mediated signaling events

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.042 0.19 -9999 0 -0.51 66 66
Syndecan-4/Syndesmos -0.044 0.21 -9999 0 -0.51 71 71
positive regulation of JNK cascade -0.072 0.22 -9999 0 -0.51 88 88
Syndecan-4/ADAM12 -0.071 0.24 -9999 0 -0.54 94 94
CCL5 -0.051 0.18 -9999 0 -0.49 71 71
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
DNM2 0.017 0.012 -9999 0 -0.25 1 1
ITGA5 0.015 0.035 -9999 0 -0.43 3 3
SDCBP 0.003 0.081 -9999 0 -0.4 19 19
PLG 0.016 0.033 -9999 0 -0.51 2 2
ADAM12 -0.051 0.17 -9999 0 -0.47 74 74
mol:GTP 0 0 -9999 0 -10000 0 0
NUDT16L1 0.01 0.063 -9999 0 -0.49 8 8
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
Syndecan-4/PKC alpha -0.006 0.012 -9999 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.041 0.21 -9999 0 -0.51 71 71
Syndecan-4/CXCL12/CXCR4 -0.077 0.24 -9999 0 -0.54 88 88
Syndecan-4/Laminin alpha3 -0.08 0.23 -9999 0 -0.55 77 77
MDK -0.016 0.12 -9999 0 -0.37 46 46
Syndecan-4/FZD7 -0.07 0.23 -9999 0 -0.53 85 85
Syndecan-4/Midkine -0.055 0.21 -9999 0 -0.52 76 76
FZD7 -0.049 0.16 -9999 0 -0.4 85 85
Syndecan-4/FGFR1/FGF -0.074 0.22 -9999 0 -0.49 87 87
THBS1 -0.025 0.14 -9999 0 -0.52 42 42
integrin-mediated signaling pathway -0.062 0.22 -9999 0 -0.51 84 84
positive regulation of MAPKKK cascade -0.072 0.22 -9999 0 -0.51 88 88
Syndecan-4/TACI -0.042 0.2 -9999 0 -0.51 72 72
CXCR4 -0.028 0.14 -9999 0 -0.42 55 55
cell adhesion -0.008 0.1 -9999 0 -0.29 56 56
Syndecan-4/Dynamin -0.04 0.2 -9999 0 -0.51 71 71
Syndecan-4/TSP1 -0.06 0.22 -9999 0 -0.52 81 81
Syndecan-4/GIPC -0.042 0.2 -9999 0 -0.51 71 71
Syndecan-4/RANTES -0.072 0.23 -9999 0 -0.55 78 78
ITGB1 0.014 0.044 -9999 0 -0.41 5 5
LAMA1 0.015 0.026 -9999 0 -0.25 5 5
LAMA3 -0.07 0.19 -9999 0 -0.43 103 103
RAC1 0.018 0 -9999 0 -10000 0 0
PRKCA 0.018 0.05 -9999 0 -0.23 8 8
Syndecan-4/alpha-Actinin -0.045 0.21 -9999 0 -0.52 73 73
TFPI 0.004 0.061 -9999 0 -0.26 25 25
F2 0.017 0.007 -9999 0 -10000 0 0
alpha5/beta1 Integrin 0.022 0.041 -9999 0 -0.37 5 5
positive regulation of cell adhesion -0.072 0.22 -9999 0 -0.52 77 77
ACTN1 0.005 0.079 -9999 0 -0.48 13 13
TNC -0.039 0.14 -9999 0 -0.36 79 79
Syndecan-4/CXCL12 -0.067 0.23 -9999 0 -0.54 82 82
FGF6 0.009 0.066 -9999 0 -0.52 8 8
RHOA 0.005 0.08 -9999 0 -0.52 12 12
CXCL12 -0.041 0.16 -9999 0 -0.47 64 64
TNFRSF13B 0.013 0.035 -9999 0 -0.25 9 9
FGF2 -0.064 0.16 -9999 0 -0.34 122 122
FGFR1 -0.013 0.11 -9999 0 -0.35 44 44
Syndecan-4/PI-4-5-P2 -0.05 0.2 -9999 0 -0.52 71 71
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.047 0.16 -9999 0 -0.45 73 73
cell migration 0.002 0.008 -9999 0 -10000 0 0
PRKCD 0.015 0.041 -9999 0 -0.44 4 4
vasculogenesis -0.057 0.21 -9999 0 -0.5 81 81
SDC4 -0.053 0.22 -9999 0 -0.55 71 71
Syndecan-4/Tenascin C -0.065 0.22 -9999 0 -0.53 84 84
Syndecan-4/PI-4-5-P2/PKC alpha -0.005 0.009 -9999 0 -10000 0 0
Syndecan-4/Syntenin -0.047 0.21 -9999 0 -0.52 73 73
MMP9 -0.04 0.17 -9999 0 -0.5 60 60
Rac1/GTP -0.008 0.1 -9999 0 -0.3 56 56
cytoskeleton organization -0.041 0.2 -9999 0 -0.49 71 71
GIPC1 0.014 0.042 -9999 0 -0.45 4 4
Syndecan-4/TFPI -0.046 0.21 -9999 0 -0.51 73 73
Signaling events mediated by the Hedgehog family

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 -0.1 0.26 -10000 0 -0.62 82 82
IHH -0.014 0.093 -10000 0 -0.48 14 14
SHH Np/Cholesterol/GAS1 -0.057 0.14 -10000 0 -0.29 133 133
LRPAP1 0.016 0.026 -10000 0 -0.39 2 2
dorsoventral neural tube patterning 0.056 0.14 0.29 133 -10000 0 133
SMO/beta Arrestin2 -0.055 0.17 -10000 0 -0.51 37 37
SMO -0.066 0.18 -10000 0 -0.55 37 37
AKT1 -0.027 0.13 -10000 0 -0.52 21 21
ARRB2 0.018 0 -10000 0 -10000 0 0
BOC -0.02 0.12 -10000 0 -0.38 50 50
ADRBK1 0.018 0 -10000 0 -10000 0 0
heart looping -0.065 0.18 -10000 0 -0.54 37 37
STIL -0.052 0.15 -10000 0 -0.37 52 52
DHH N/PTCH2 0.026 0 -10000 0 -10000 0 0
DHH N/PTCH1 -0.028 0.13 -10000 0 -0.37 24 24
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
DHH 0.018 0 -10000 0 -10000 0 0
PTHLH -0.12 0.31 -10000 0 -0.83 66 66
determination of left/right symmetry -0.065 0.18 -10000 0 -0.54 37 37
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
skeletal system development -0.12 0.31 -10000 0 -0.82 66 66
IHH N/Hhip 0.004 0.068 -10000 0 -0.29 22 22
DHH N/Hhip 0.021 0.037 -10000 0 -0.37 3 3
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.065 0.18 -10000 0 -0.54 37 37
pancreas development 0.011 0.052 -10000 0 -0.33 11 11
HHAT -0.045 0.17 -10000 0 -0.51 63 63
PI3K 0.005 0.082 -10000 0 -0.37 21 21
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.072 0.19 -10000 0 -0.47 98 98
somite specification -0.065 0.18 -10000 0 -0.54 37 37
SHH Np/Cholesterol/PTCH1 -0.049 0.14 -10000 0 -0.37 44 44
SHH Np/Cholesterol/PTCH2 -0.007 0.098 -10000 0 -0.28 61 61
SHH Np/Cholesterol/Megalin -0.1 0.18 -10000 0 -0.33 181 181
SHH -0.021 0.13 -10000 0 -0.37 61 61
catabolic process -0.042 0.14 -10000 0 -0.42 24 24
SMO/Vitamin D3 -0.061 0.17 -10000 0 -0.46 40 40
SHH Np/Cholesterol/Hhip -0.01 0.1 -10000 0 -0.28 64 64
LRP2 -0.16 0.24 -10000 0 -0.48 183 183
receptor-mediated endocytosis -0.12 0.2 -10000 0 -0.49 74 74
SHH Np/Cholesterol/BOC -0.027 0.12 -10000 0 -0.28 85 85
SHH Np/Cholesterol/CDO -0.019 0.11 -10000 0 -0.29 74 74
mesenchymal cell differentiation 0.011 0.1 0.28 64 -10000 0 64
mol:Vitamin D3 -0.047 0.14 -10000 0 -0.37 44 44
IHH N/PTCH2 0.01 0.055 -10000 0 -0.32 11 11
CDON -0.004 0.099 -10000 0 -0.41 27 27
IHH N/PTCH1 -0.04 0.14 -10000 0 -0.42 24 24
Megalin/LRPAP1 -0.1 0.18 -10000 0 -0.37 158 158
PTCH2 0.018 0 -10000 0 -10000 0 0
SHH Np/Cholesterol -0.017 0.097 -10000 0 -0.28 61 61
PTCH1 -0.043 0.14 -10000 0 -0.42 24 24
HHIP 0.011 0.052 -10000 0 -0.33 11 11
BMP receptor signaling

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.065 0.13 -9999 0 -0.32 63 63
SMAD6-7/SMURF1 0.034 0.021 -9999 0 -0.3 1 1
NOG 0.009 0.056 -9999 0 -0.31 14 14
SMAD9 -0.023 0.12 -9999 0 -0.65 12 12
SMAD4 0.009 0.067 -9999 0 -0.49 9 9
SMAD5 -0.062 0.14 -9999 0 -0.38 56 56
BMP7/USAG1 -0.18 0.18 -9999 0 -0.39 202 202
SMAD5/SKI -0.051 0.14 -9999 0 -0.39 43 43
SMAD1 0.024 0.061 -9999 0 -0.37 7 7
BMP2 -0.019 0.11 -9999 0 -0.32 58 58
SMAD1/SMAD1/SMAD4 -0.01 0.044 -9999 0 -0.33 3 3
BMPR1A 0.009 0.068 -9999 0 -0.47 10 10
BMPR1B -0.11 0.16 -9999 0 -0.29 216 216
BMPR1A-1B/BAMBI -0.13 0.17 -9999 0 -0.36 157 157
AHSG 0.016 0.024 -9999 0 -0.25 4 4
CER1 0.017 0.012 -9999 0 -0.25 1 1
BMP2-4/CER1 -0.052 0.14 -9999 0 -0.35 84 84
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.053 0.14 -9999 0 -0.38 43 43
BMP2-4 (homodimer) -0.075 0.16 -9999 0 -0.42 83 83
RGMB 0.009 0.07 -9999 0 -0.52 9 9
BMP6/BMPR2/BMPR1A-1B -0.042 0.11 -9999 0 -0.3 53 53
RGMA -0.027 0.12 -9999 0 -0.3 75 75
SMURF1 0.018 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.072 0.14 -9999 0 -0.32 96 96
BMP2-4/USAG1 -0.2 0.2 -9999 0 -0.38 245 245
SMAD6/SMURF1/SMAD5 -0.051 0.14 -9999 0 -0.39 41 41
SOSTDC1 -0.23 0.23 -9999 0 -0.39 314 314
BMP7/BMPR2/BMPR1A-1B -0.06 0.12 -9999 0 -0.3 68 68
SKI 0.017 0.017 -9999 0 -0.25 2 2
BMP6 (homodimer) -0.006 0.089 -9999 0 -0.3 40 40
HFE2 0.004 0.08 -9999 0 -0.45 15 15
ZFYVE16 0.016 0.033 -9999 0 -0.52 2 2
MAP3K7 0.016 0.02 -9999 0 -0.25 3 3
BMP2-4/CHRD -0.059 0.16 -9999 0 -0.37 84 84
SMAD5/SMAD5/SMAD4 -0.055 0.14 -9999 0 -0.39 45 45
MAPK1 0.016 0.033 -9999 0 -0.52 2 2
TAK1/TAB family -0.032 0.13 -9999 0 -0.43 25 25
BMP7 (homodimer) -0.041 0.13 -9999 0 -0.29 101 101
NUP214 0.016 0.026 -9999 0 -0.39 2 2
BMP6/FETUA 0.008 0.065 -9999 0 -0.36 8 8
SMAD1/SKI 0.032 0.06 -9999 0 -0.34 7 7
SMAD6 0.016 0.024 -9999 0 -0.25 4 4
CTDSP2 0.014 0.044 -9999 0 -0.41 5 5
BMP2-4/FETUA -0.053 0.14 -9999 0 -0.35 84 84
MAP3K7IP1 0.018 0 -9999 0 -10000 0 0
GREM1 -0.038 0.16 -9999 0 -0.45 63 63
BMPR2 (homodimer) 0.016 0.033 -9999 0 -0.52 2 2
GADD34/PP1CA 0.03 0.04 -9999 0 -0.3 5 5
BMPR1A-1B (homodimer) -0.068 0.12 -9999 0 -0.38 39 39
CHRDL1 -0.013 0.09 -9999 0 -0.27 56 56
ENDOFIN/SMAD1 0.032 0.063 -9999 0 -0.36 8 8
SMAD6-7/SMURF1/SMAD1 0.046 0.058 -9999 0 -0.37 3 3
SMAD6/SMURF1 0.018 0 -9999 0 -10000 0 0
BAMBI -0.13 0.22 -9999 0 -0.41 182 182
SMURF2 0.009 0.058 -9999 0 -0.34 13 13
BMP2-4/CHRDL1 -0.068 0.16 -9999 0 -0.36 97 97
BMP2-4/GREM1 -0.085 0.18 -9999 0 -0.37 119 119
SMAD7 0.016 0.026 -9999 0 -0.39 2 2
SMAD8A/SMAD8A/SMAD4 -0.016 0.11 -9999 0 -0.47 20 20
SMAD1/SMAD6 0.033 0.06 -9999 0 -0.34 7 7
TAK1/SMAD6 0.025 0.014 -9999 0 -10000 0 0
BMP7 -0.041 0.13 -9999 0 -0.29 101 101
BMP6 -0.006 0.089 -9999 0 -0.3 40 40
MAP3K7IP2 0.014 0.047 -9999 0 -0.52 4 4
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.052 0.13 -9999 0 -0.37 40 40
PPM1A 0.016 0.026 -9999 0 -0.39 2 2
SMAD1/SMURF2 0.029 0.067 -9999 0 -0.35 8 8
SMAD7/SMURF1 0.025 0.019 -9999 0 -0.37 1 1
CTDSPL 0.011 0.062 -9999 0 -0.52 7 7
PPP1CA 0.011 0.048 -9999 0 -0.3 11 11
XIAP 0 0 -9999 0 -10000 0 0
CTDSP1 0.016 0.033 -9999 0 -0.52 2 2
PPP1R15A 0.016 0.029 -9999 0 -0.34 3 3
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.081 0.16 -9999 0 -0.36 89 89
CHRD 0.003 0.073 -9999 0 -0.33 22 22
BMPR2 0.016 0.033 -9999 0 -0.52 2 2
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.074 0.15 -9999 0 -0.33 96 96
BMP4 -0.092 0.19 -9999 0 -0.39 143 143
FST -0.017 0.11 -9999 0 -0.32 54 54
BMP2-4/NOG -0.056 0.15 -9999 0 -0.35 88 88
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.048 0.11 -9999 0 -0.3 53 53
ErbB4 signaling events

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF -0.1 0.3 -10000 0 -0.91 53 53
epithelial cell differentiation -0.1 0.23 -10000 0 -0.72 56 56
ITCH 0.019 0.028 -10000 0 -10000 0 0
WWP1 -0.13 0.4 -10000 0 -1.4 44 44
FYN 0.008 0.067 -10000 0 -0.41 12 12
EGFR -0.079 0.18 -10000 0 -0.35 139 139
PRL 0.015 0.031 -10000 0 -0.32 4 4
neuron projection morphogenesis -0.032 0.22 -10000 0 -0.71 45 45
PTPRZ1 -0.028 0.11 -10000 0 -0.29 79 79
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.047 0.25 -10000 0 -0.82 45 45
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.08 0.27 -10000 0 -0.93 45 45
ADAM17 0.017 0.037 -10000 0 -0.26 4 4
ErbB4/ErbB4 -0.11 0.32 -10000 0 -0.99 52 52
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.1 0.3 -10000 0 -0.88 56 56
NCOR1 0.016 0.033 -10000 0 -0.52 2 2
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.073 0.26 -10000 0 -0.88 46 46
GRIN2B -0.074 0.25 -10000 0 -0.82 47 47
ErbB4/ErbB2/betacellulin -0.12 0.28 -10000 0 -0.73 71 71
STAT1 -0.02 0.12 -10000 0 -0.33 58 58
HBEGF 0.005 0.072 -10000 0 -0.36 18 18
PRLR -0.03 0.15 -10000 0 -0.49 50 50
E4ICDs/ETO2 -0.17 0.34 -10000 0 -0.79 89 89
axon guidance -0.079 0.28 -10000 0 -0.91 47 47
NEDD4 0.003 0.095 -10000 0 -0.53 15 15
Prolactin receptor/Prolactin receptor/Prolactin -0.01 0.11 -10000 0 -0.37 45 45
CBFA2T3 -0.13 0.23 -10000 0 -0.45 162 162
ErbB4/ErbB2/HBEGF -0.091 0.27 -10000 0 -0.81 54 54
MAPK3 -0.04 0.23 -10000 0 -0.75 45 45
STAT1 (dimer) -0.11 0.3 -10000 0 -0.9 56 56
MAPK1 -0.04 0.23 -10000 0 -0.75 45 45
JAK2 0.01 0.053 -10000 0 -0.32 12 12
ErbB4/ErbB2/neuregulin 1 beta -0.09 0.27 -10000 0 -0.83 52 52
NRG1 0.018 0.047 -10000 0 -0.36 3 3
NRG3 0 0.081 -10000 0 -0.34 26 26
NRG2 -0.017 0.1 -10000 0 -0.3 57 57
NRG4 0.009 0.051 -10000 0 -0.27 16 16
heart development -0.079 0.28 -10000 0 -0.91 47 47
neural crest cell migration -0.088 0.26 -10000 0 -0.82 52 52
ERBB2 -0.007 0.088 -10000 0 -0.35 18 18
WWOX/E4ICDs -0.1 0.29 -10000 0 -0.91 52 52
SHC1 0.017 0.023 -10000 0 -0.52 1 1
ErbB4/EGFR/neuregulin 4 -0.13 0.31 -10000 0 -0.85 63 63
apoptosis 0.097 0.28 0.9 49 -10000 0 49
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.11 0.31 -10000 0 -0.92 55 55
ErbB4/ErbB2/epiregulin -0.1 0.27 -10000 0 -0.81 55 55
ErbB4/ErbB4/betacellulin/betacellulin -0.13 0.3 -10000 0 -0.88 60 60
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.088 0.29 -10000 0 -0.72 74 74
MDM2 -0.096 0.3 -10000 0 -0.92 52 52
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.062 0.25 -10000 0 -0.84 44 44
STAT5A -0.072 0.27 -10000 0 -0.88 47 47
ErbB4/EGFR/neuregulin 1 beta -0.11 0.28 -10000 0 -0.8 61 61
DLG4 0.018 0 -10000 0 -10000 0 0
GRB2/SHC 0.024 0.023 -10000 0 -0.37 1 1
E4ICDs/TAB2/NCoR1 -0.081 0.28 -10000 0 -0.93 47 47
STAT5A (dimer) -0.11 0.26 -10000 0 -0.81 56 56
MAP3K7IP2 0.014 0.047 -10000 0 -0.52 4 4
STAT5B (dimer) -0.068 0.27 -10000 0 -0.86 48 48
LRIG1 -0.032 0.15 -10000 0 -0.48 53 53
EREG -0.024 0.11 -10000 0 -0.28 74 74
BTC -0.05 0.17 -10000 0 -0.42 82 82
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.081 0.28 -10000 0 -0.93 47 47
ERBB4 -0.11 0.32 -10000 0 -1 52 52
STAT5B 0.016 0.026 -10000 0 -0.39 2 2
YAP1 -0.014 0.1 -10000 0 -0.71 6 6
GRB2 0.016 0.024 -10000 0 -0.25 4 4
ErbB4/ErbB2/neuregulin 4 -0.088 0.27 -10000 0 -0.83 52 52
glial cell differentiation 0.079 0.28 0.91 47 -10000 0 47
WWOX -0.003 0.072 -10000 0 -0.25 40 40
cell proliferation -0.1 0.27 -10000 0 -0.81 54 54
IL2 signaling events mediated by PI3K

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.005 0.13 -10000 0 -0.46 25 25
UGCG -0.11 0.27 -10000 0 -0.77 74 74
AKT1/mTOR/p70S6K/Hsp90/TERT -0.07 0.19 -10000 0 -0.38 100 100
mol:GTP 0 0.001 -10000 0 -10000 0 0
mol:glucosylceramide -0.11 0.27 -10000 0 -0.76 74 74
mol:DAG -0.014 0.12 -10000 0 -0.95 8 8
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.14 0.2 -10000 0 -0.42 149 149
FRAP1 -0.12 0.26 -10000 0 -0.47 159 159
FOXO3 -0.064 0.19 -10000 0 -0.4 89 89
AKT1 -0.073 0.21 -10000 0 -0.43 93 93
GAB2 0.007 0.048 -10000 0 -0.25 17 17
SMPD1 -0.004 0.079 -10000 0 -0.8 4 4
SGMS1 -0.01 0.099 -10000 0 -0.73 8 8
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP 0 0.069 -10000 0 -0.31 21 21
CALM1 0.018 0 -10000 0 -10000 0 0
cell proliferation -0.088 0.2 -10000 0 -0.42 119 119
EIF3A 0.017 0.012 -10000 0 -0.25 1 1
PI3K 0.006 0.083 -10000 0 -0.37 21 21
RPS6KB1 -0.034 0.1 -10000 0 -0.24 62 62
mol:sphingomyelin -0.014 0.12 -10000 0 -0.95 8 8
natural killer cell activation -0.002 0.004 -10000 0 -0.013 30 30
JAK3 0.018 0.004 -10000 0 -10000 0 0
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
JAK1 0.012 0.057 -10000 0 -0.52 6 6
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
MYC -0.091 0.28 -10000 0 -0.81 50 50
MYB -0.23 0.5 -10000 0 -1.2 108 108
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.043 0.16 -10000 0 -0.36 66 66
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.014 0.099 -10000 0 -0.38 4 4
mol:PI-3-4-5-P3 -0.042 0.16 -10000 0 -0.35 66 66
Rac1/GDP 0.011 0.064 -10000 0 -0.28 21 21
T cell proliferation -0.038 0.15 -10000 0 -0.33 66 66
SHC1 0.015 0.024 -10000 0 -0.52 1 1
RAC1 0.017 0.001 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity -0.009 0.029 -10000 0 -0.061 118 118
PRKCZ -0.04 0.15 -10000 0 -0.34 66 66
NF kappa B1 p50/RelA -0.085 0.23 -10000 0 -0.46 108 108
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.016 0.14 -10000 0 -0.49 28 28
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
RELA 0.018 0 -10000 0 -10000 0 0
IL2RA -0.032 0.14 -10000 0 -0.41 60 60
IL2RB -0.016 0.12 -10000 0 -0.43 40 40
TERT 0.013 0.042 -10000 0 -0.33 7 7
E2F1 -0.076 0.19 -10000 0 -0.44 113 113
SOS1 0.015 0.024 -10000 0 -0.53 1 1
RPS6 0.015 0.037 -10000 0 -0.39 4 4
mol:cAMP 0.004 0.014 0.029 119 -10000 0 119
PTPN11 0.015 0.024 -10000 0 -0.52 1 1
IL2RG -0.002 0.078 -10000 0 -0.28 35 35
actin cytoskeleton organization -0.038 0.15 -10000 0 -0.33 66 66
GRB2 0.014 0.024 -10000 0 -0.25 4 4
IL2 0.011 0.051 -10000 0 -0.33 10 10
PIK3CA 0.016 0.03 -10000 0 -0.35 3 3
Rac1/GTP 0.013 0.064 -10000 0 -0.26 21 21
LCK -0.073 0.18 -10000 0 -0.4 117 117
BCL2 -0.19 0.39 -10000 0 -0.83 129 129
amb2 Integrin signaling

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.029 0.15 -9999 0 -0.39 65 65
alphaM/beta2 Integrin/GPIbA -0.011 0.11 -9999 0 -0.33 42 42
alphaM/beta2 Integrin/proMMP-9 -0.036 0.15 -9999 0 -0.36 83 83
PLAUR -0.016 0.13 -9999 0 -0.47 37 37
HMGB1 0.011 0.021 -9999 0 -0.27 1 1
alphaM/beta2 Integrin/Talin 0 0.1 -9999 0 -0.36 31 31
AGER 0.01 0.031 -9999 0 -0.39 2 2
RAP1A 0.012 0.057 -9999 0 -0.52 6 6
SELPLG -0.003 0.097 -9999 0 -0.43 24 24
mol:LDL 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.012 0.13 -9999 0 -0.36 39 39
mol:GTP 0 0 -9999 0 -10000 0 0
MMP9 -0.042 0.17 -9999 0 -0.51 60 60
CYR61 -0.042 0.16 -9999 0 -0.42 72 72
TLN1 0.017 0.023 -9999 0 -0.52 1 1
Rap1/GTP -0.036 0.1 -9999 0 -0.42 26 26
RHOA 0.005 0.08 -9999 0 -0.52 12 12
P-selectin oligomer -0.12 0.22 -9999 0 -0.44 156 156
MYH2 -0.003 0.13 -9999 0 -0.41 29 29
MST1R -0.039 0.16 -9999 0 -0.51 57 57
leukocyte activation during inflammatory response 0.008 0.086 -9999 0 -0.31 30 30
APOB 0.018 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
complement component iC3b receptor activity 0 0 -9999 0 -10000 0 0
MMP2 -0.032 0.15 -9999 0 -0.47 54 54
JAM3 -0.006 0.11 -9999 0 -0.5 24 24
GP1BA -0.002 0.071 -9999 0 -0.25 39 39
alphaM/beta2 Integrin/CTGF -0.031 0.14 -9999 0 -0.39 59 59
alphaM/beta2 Integrin -0.008 0.13 -9999 0 -0.43 29 29
JAM3 homodimer -0.006 0.11 -9999 0 -0.5 24 24
ICAM2 0.007 0.068 -9999 0 -0.4 13 13
ICAM1 -0.019 0.12 -9999 0 -0.39 47 47
phagocytosis triggered by activation of immune response cell surface activating receptor -0.008 0.13 -9999 0 -0.43 29 29
cell adhesion -0.011 0.11 -9999 0 -0.33 42 42
NFKB1 -0.032 0.17 -9999 0 -0.38 76 76
THY1 -0.007 0.11 -9999 0 -0.5 25 25
RhoA/GDP 0.004 0.058 -9999 0 -0.38 12 12
Lipoprotein(a) 0.023 0.016 -9999 0 -0.31 1 1
alphaM/beta2 Integrin/LRP/tPA -0.049 0.14 -9999 0 -0.32 93 93
IL6 -0.087 0.27 -9999 0 -0.71 71 71
ITGB2 -0.022 0.12 -9999 0 -0.43 40 40
elevation of cytosolic calcium ion concentration -0.044 0.18 -9999 0 -0.41 82 82
alphaM/beta2 Integrin/JAM2/JAM3 -0.02 0.15 -9999 0 -0.38 64 64
JAM2 -0.019 0.13 -9999 0 -0.43 43 43
alphaM/beta2 Integrin/ICAM1 -0.028 0.16 -9999 0 -0.33 91 91
alphaM/beta2 Integrin/uPA/Plg -0.027 0.14 -9999 0 -0.34 75 75
RhoA/GTP -0.008 0.14 -9999 0 -0.44 30 30
positive regulation of phagocytosis -0.007 0.16 -9999 0 -0.46 42 42
Ron/MSP -0.017 0.12 -9999 0 -0.37 55 55
alphaM/beta2 Integrin/uPAR/uPA -0.044 0.18 -9999 0 -0.41 82 82
alphaM/beta2 Integrin/uPAR -0.019 0.14 -9999 0 -0.39 53 53
PLAU -0.052 0.17 -9999 0 -0.43 83 83
PLAT -0.093 0.19 -9999 0 -0.37 150 150
actin filament polymerization -0.001 0.13 -9999 0 -0.4 29 29
MST1 0.016 0.02 -9999 0 -0.25 3 3
alphaM/beta2 Integrin/lipoprotein(a) 0.011 0.088 -9999 0 -0.31 30 30
TNF -0.035 0.19 -9999 0 -0.61 32 32
RAP1B 0.013 0.044 -9999 0 -0.32 8 8
alphaM/beta2 Integrin/uPA -0.041 0.15 -9999 0 -0.37 75 75
fibrinolysis -0.028 0.14 -9999 0 -0.34 75 75
HCK -0.005 0.11 -9999 0 -0.47 25 25
dendritic cell antigen processing and presentation -0.008 0.13 -9999 0 -0.43 29 29
VTN 0.016 0.02 -9999 0 -0.25 3 3
alphaM/beta2 Integrin/CYR61 -0.035 0.14 -9999 0 -0.36 70 70
LPA 0.016 0.026 -9999 0 -0.39 2 2
LRP1 0.017 0.023 -9999 0 -0.52 1 1
cell migration -0.051 0.18 -9999 0 -0.36 107 107
FN1 -0.048 0.17 -9999 0 -0.46 73 73
alphaM/beta2 Integrin/Thy1 -0.014 0.12 -9999 0 -0.36 50 50
MPO 0.008 0.05 -9999 0 -0.25 19 19
KNG1 0.017 0.017 -9999 0 -0.25 2 2
RAP1/GDP 0.017 0.044 -9999 0 -0.31 8 8
ROCK1 0 0.13 -9999 0 -0.41 29 29
ELA2 0.017 0.017 -9999 0 -0.25 2 2
PLG 0.016 0.033 -9999 0 -0.52 2 2
CTGF -0.035 0.15 -9999 0 -0.42 63 63
alphaM/beta2 Integrin/Hck -0.012 0.14 -9999 0 -0.43 42 42
ITGAM 0.002 0.071 -9999 0 -0.48 10 10
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.072 0.18 -9999 0 -0.34 132 132
HP 0.013 0.049 -9999 0 -0.43 6 6
leukocyte adhesion -0.034 0.18 -9999 0 -0.54 43 43
SELP -0.12 0.22 -9999 0 -0.44 156 156
Ephrin B reverse signaling

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 -0.008 0.11 -10000 0 -0.4 33 33
EPHB2 0.008 0.062 -10000 0 -0.32 16 16
EFNB1 0.017 0.051 -10000 0 -0.4 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.021 0.082 -10000 0 -0.34 9 9
Ephrin B2/EPHB1-2 -0.006 0.089 -10000 0 -0.28 34 34
neuron projection morphogenesis -0.023 0.061 -10000 0 -0.31 10 10
Ephrin B1/EPHB1-2/Tiam1 0.015 0.087 -10000 0 -0.29 22 22
DNM1 0.013 0.047 -10000 0 -0.37 7 7
cell-cell signaling 0 0.002 -10000 0 -10000 0 0
MAP2K4 -0.084 0.23 -10000 0 -0.59 84 84
YES1 -0.13 0.3 -10000 0 -0.84 81 81
Ephrin B1/EPHB1-2/NCK2 0.019 0.078 -10000 0 -0.28 17 17
PI3K -0.081 0.24 -10000 0 -0.6 83 83
mol:GDP 0.013 0.086 -10000 0 -0.29 22 22
ITGA2B 0.016 0.02 -10000 0 -0.25 3 3
endothelial cell proliferation -0.01 0.1 -10000 0 -0.33 40 40
FYN -0.13 0.3 -10000 0 -0.83 81 81
MAP3K7 -0.084 0.23 -10000 0 -0.63 81 81
FGR -0.11 0.3 -10000 0 -0.82 81 81
TIAM1 0.006 0.073 -10000 0 -0.44 13 13
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
RGS3 0.017 0.012 -10000 0 -0.25 1 1
cell adhesion -0.069 0.22 -10000 0 -0.56 82 82
LYN -0.12 0.3 -10000 0 -0.83 81 81
Ephrin B1/EPHB1-2/Src Family Kinases -0.12 0.28 -10000 0 -0.77 81 81
Ephrin B1/EPHB1-2 -0.11 0.25 -10000 0 -0.68 81 81
SRC -0.11 0.3 -10000 0 -0.82 81 81
ITGB3 0.002 0.075 -10000 0 -0.32 25 25
EPHB1 -0.022 0.1 -10000 0 -0.28 72 72
EPHB4 -0.013 0.12 -10000 0 -0.43 36 36
RAC1 0.018 0 -10000 0 -10000 0 0
Ephrin B2/EPHB4 -0.01 0.1 -10000 0 -0.34 40 40
alphaIIb/beta3 Integrin 0.014 0.056 -10000 0 -0.36 7 7
BLK -0.13 0.3 -10000 0 -0.83 81 81
HCK -0.13 0.3 -10000 0 -0.83 81 81
regulation of stress fiber formation -0.018 0.076 0.28 17 -10000 0 17
MAPK8 -0.074 0.22 -10000 0 -0.56 82 82
Ephrin B1/EPHB1-2/RGS3 0.02 0.075 -10000 0 -0.27 15 15
endothelial cell migration -0.09 0.22 -10000 0 -0.53 92 92
NCK2 0.015 0.026 -10000 0 -0.25 5 5
PTPN13 -0.089 0.24 -10000 0 -0.64 81 81
regulation of focal adhesion formation -0.018 0.076 0.28 17 -10000 0 17
chemotaxis -0.019 0.074 0.27 15 -10000 0 15
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
Rac1/GTP 0.015 0.078 -10000 0 -0.33 9 9
angiogenesis -0.11 0.24 -10000 0 -0.68 81 81
LCK -0.14 0.31 -10000 0 -0.84 81 81
LPA receptor mediated events

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.005 0.08 -9999 0 -0.24 48 48
NF kappa B1 p50/RelA/I kappa B alpha 0.003 0.086 -9999 0 -0.31 14 14
AP1 -0.092 0.14 -9999 0 -0.3 133 133
mol:PIP3 -0.067 0.11 -9999 0 -0.28 85 85
AKT1 0.007 0.11 -9999 0 -0.36 24 24
PTK2B -0.009 0.064 -9999 0 -0.2 47 47
RHOA -0.007 0.093 -9999 0 -0.41 17 17
PIK3CB 0.012 0.055 -9999 0 -0.44 7 7
mol:Ca2+ -0.025 0.094 -9999 0 -0.26 61 61
MAGI3 -0.014 0.12 -9999 0 -0.46 35 35
RELA 0.018 0 -9999 0 -10000 0 0
apoptosis -0.004 0.067 -9999 0 -0.22 44 44
HRAS/GDP 0.009 0.036 -9999 0 -0.29 7 7
positive regulation of microtubule depolymerization -0.045 0.12 -9999 0 -0.26 116 116
NF kappa B1 p50/RelA -0.04 0.092 -9999 0 -0.32 30 30
endothelial cell migration -0.036 0.18 -9999 0 -0.55 54 54
ADCY4 -0.005 0.11 -9999 0 -0.3 48 48
ADCY5 -0.014 0.11 -9999 0 -0.31 48 48
ADCY6 -0.004 0.1 -9999 0 -0.29 47 47
ADCY7 -0.007 0.11 -9999 0 -0.32 47 47
ADCY1 -0.003 0.1 -9999 0 -0.29 47 47
ADCY2 -0.025 0.12 -9999 0 -0.35 51 51
ADCY3 -0.006 0.1 -9999 0 -0.29 49 49
ADCY8 -0.005 0.1 -9999 0 -0.29 47 47
ADCY9 -0.01 0.11 -9999 0 -0.29 48 48
GSK3B -0.002 0.061 -9999 0 -0.18 44 44
arachidonic acid secretion 0.001 0.1 -9999 0 -0.28 49 49
GNG2 0.016 0.029 -9999 0 -0.34 3 3
TRIP6 0 0.088 -9999 0 -0.4 23 23
GNAO1 -0.004 0.078 -9999 0 -0.25 44 44
HRAS 0.012 0.051 -9999 0 -0.41 7 7
NFKBIA -0.014 0.091 -9999 0 -0.3 23 23
GAB1 0.006 0.074 -9999 0 -0.43 14 14
mol:GTP 0 0 -9999 0 -10000 0 0
lamellipodium assembly 0.006 0.15 -9999 0 -0.89 15 15
JUN -0.034 0.15 -9999 0 -0.46 57 57
LPA/LPA2/NHERF2 -0.024 0.1 -9999 0 -0.31 52 52
TIAM1 -0.025 0.18 -9999 0 -1 15 15
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
mol:IP3 -0.025 0.095 -9999 0 -0.26 61 61
PLCB3 -0.016 0.094 -9999 0 -0.3 49 49
FOS -0.11 0.2 -9999 0 -0.37 171 171
positive regulation of mitosis 0.001 0.1 -9999 0 -0.28 49 49
LPA/LPA1-2-3 -0.015 0.068 -9999 0 -0.21 54 54
mol:Ca ++ 0 0 -9999 0 -10000 0 0
JNK cascade 0 0 -9999 0 -10000 0 0
BCAR1 0.017 0.012 -9999 0 -0.25 1 1
stress fiber formation 0.001 0.063 -9999 0 -0.19 45 45
GNAZ -0.013 0.096 -9999 0 -0.28 55 55
EGFR/PI3K-beta/Gab1 -0.069 0.12 -9999 0 -0.3 85 85
positive regulation of dendritic cell cytokine production -0.015 0.068 -9999 0 -0.21 54 54
LPA/LPA2/MAGI-3 -0.013 0.08 -9999 0 -0.28 35 35
ARHGEF1 0.009 0.074 -9999 0 -0.22 36 36
GNAI2 -0.01 0.095 -9999 0 -0.29 49 49
GNAI3 -0.003 0.077 -9999 0 -0.25 44 44
GNAI1 -0.023 0.11 -9999 0 -0.31 58 58
LPA/LPA3 -0.011 0.033 -9999 0 -0.11 54 54
LPA/LPA2 -0.011 0.033 -9999 0 -0.1 54 54
LPA/LPA1 -0.019 0.09 -9999 0 -0.28 54 54
HB-EGF/EGFR -0.069 0.16 -9999 0 -0.35 104 104
HBEGF -0.027 0.13 -9999 0 -0.38 64 64
mol:DAG -0.025 0.095 -9999 0 -0.26 61 61
cAMP biosynthetic process -0.007 0.11 -9999 0 -0.3 51 51
NFKB1 0.017 0.023 -9999 0 -0.52 1 1
SRC 0.015 0.035 -9999 0 -0.43 3 3
GNB1 0.013 0.052 -9999 0 -0.52 5 5
LYN -0.013 0.088 -9999 0 -0.27 29 29
GNAQ -0.005 0.027 -9999 0 -0.082 54 54
LPAR2 0 0.001 -9999 0 -10000 0 0
LPAR3 0 0.001 -9999 0 -10000 0 0
LPAR1 -0.012 0.052 -9999 0 -0.16 54 54
IL8 -0.13 0.19 -9999 0 -0.41 122 122
PTK2 -0.003 0.067 -9999 0 -0.21 45 45
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
CASP3 -0.004 0.068 -9999 0 -0.22 44 44
EGFR -0.079 0.18 -9999 0 -0.35 139 139
PLCG1 -0.014 0.056 -9999 0 -0.14 66 66
PLD2 -0.004 0.071 -9999 0 -0.22 47 47
G12/G13 0.005 0.08 -9999 0 -0.24 46 46
PI3K-beta -0.039 0.098 -9999 0 -0.36 30 30
cell migration 0.016 0.062 -9999 0 -0.25 17 17
SLC9A3R2 -0.032 0.15 -9999 0 -0.49 52 52
PXN 0.001 0.064 -9999 0 -0.2 45 45
HRAS/GTP 0.001 0.1 -9999 0 -0.28 49 49
RAC1 0.018 0 -9999 0 -10000 0 0
MMP9 -0.042 0.17 -9999 0 -0.51 60 60
PRKCE 0.01 0.061 -9999 0 -0.43 9 9
PRKCD -0.019 0.094 -9999 0 -0.26 56 56
Gi(beta/gamma) 0 0.11 -9999 0 -0.29 48 48
mol:LPA -0.012 0.052 -9999 0 -0.16 54 54
TRIP6/p130 Cas/FAK1/Paxillin 0.012 0.086 -9999 0 -0.34 13 13
MAPKKK cascade 0.001 0.1 -9999 0 -0.28 49 49
contractile ring contraction involved in cytokinesis -0.007 0.092 -9999 0 -0.4 17 17
mol:GDP 0 0 -9999 0 -10000 0 0
GNA14 -0.043 0.096 -9999 0 -0.25 70 70
GNA15 -0.003 0.051 -9999 0 -0.18 23 23
GNA12 0.018 0 -9999 0 -10000 0 0
GNA13 0.011 0.055 -9999 0 -0.36 10 10
MAPT -0.047 0.13 -9999 0 -0.27 116 116
GNA11 0.002 0.038 -9999 0 -0.3 4 4
Rac1/GTP 0.005 0.16 -9999 0 -0.94 15 15
MMP2 -0.036 0.18 -9999 0 -0.55 54 54
BCR signaling pathway

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.061 0.16 -10000 0 -0.39 72 72
IKBKB 0.005 0.077 -10000 0 -0.25 11 11
AKT1 -0.017 0.098 0.21 10 -0.22 49 59
IKBKG 0.008 0.078 -10000 0 -0.25 11 11
CALM1 -0.03 0.13 0.21 11 -0.35 48 59
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
MAP3K1 -0.075 0.19 -10000 0 -0.47 69 69
MAP3K7 0.016 0.02 -10000 0 -0.25 3 3
mol:Ca2+ -0.039 0.14 0.21 11 -0.35 57 68
DOK1 0.002 0.083 -10000 0 -0.41 19 19
AP-1 -0.045 0.1 0.18 1 -0.24 73 74
LYN 0.014 0.031 -10000 0 -0.25 7 7
BLNK -0.012 0.12 -10000 0 -0.51 30 30
SHC1 0.017 0.023 -10000 0 -0.52 1 1
BCR complex -0.033 0.13 -10000 0 -0.34 71 71
CD22 -0.055 0.19 -10000 0 -0.48 63 63
CAMK2G -0.022 0.12 0.21 11 -0.33 45 56
CSNK2A1 0.017 0.023 -10000 0 -0.52 1 1
INPP5D 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.057 0.11 -10000 0 -0.44 21 21
GO:0007205 -0.04 0.14 0.21 11 -0.36 57 68
SYK -0.023 0.14 -10000 0 -0.48 43 43
ELK1 -0.032 0.13 0.21 11 -0.36 49 60
NFATC1 -0.04 0.16 -10000 0 -0.38 64 64
B-cell antigen/BCR complex -0.033 0.13 -10000 0 -0.34 71 71
PAG1/CSK 0.009 0.074 -10000 0 -0.37 16 16
NFKBIB 0.014 0.031 0.097 1 -0.11 3 4
HRAS -0.028 0.13 0.19 3 -0.33 51 54
NFKBIA 0.015 0.03 0.097 1 -0.13 1 2
NF-kappa-B/RelA/I kappa B beta 0.02 0.027 -10000 0 -0.16 1 1
RasGAP/Csk -0.026 0.14 -10000 0 -0.31 77 77
mol:GDP -0.038 0.13 0.21 11 -0.34 57 68
PTEN -0.002 0.1 -10000 0 -0.52 19 19
CD79B -0.042 0.15 -10000 0 -0.36 84 84
NF-kappa-B/RelA/I kappa B alpha 0.02 0.027 -10000 0 -0.16 1 1
GRB2 0.016 0.024 -10000 0 -0.25 4 4
PI3K/BCAP/CD19 -0.063 0.18 -10000 0 -0.48 60 60
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
mol:IP3 -0.041 0.14 0.21 11 -0.36 57 68
CSK 0.015 0.031 -10000 0 -0.32 4 4
FOS -0.078 0.15 0.21 8 -0.32 113 121
CHUK 0.001 0.094 -10000 0 -0.32 21 21
IBTK 0.016 0.033 -10000 0 -0.52 2 2
CARD11/BCL10/MALT1/TAK1 -0.023 0.12 0.2 1 -0.36 39 40
PTPN6 -0.046 0.18 -10000 0 -0.52 48 48
RELA 0.018 0 -10000 0 -10000 0 0
BCL2A1 0.013 0.03 -10000 0 -0.096 9 9
VAV2 -0.065 0.19 -10000 0 -0.51 60 60
ubiquitin-dependent protein catabolic process 0.019 0.03 0.1 1 -0.11 2 3
BTK -0.036 0.2 -10000 0 -1.1 18 18
CD19 -0.073 0.2 -10000 0 -0.44 90 90
MAP4K1 0.012 0.04 -10000 0 -0.25 12 12
CD72 -0.03 0.14 -10000 0 -0.37 65 65
PAG1 -0.005 0.097 -10000 0 -0.38 30 30
MAPK14 -0.057 0.16 -10000 0 -0.41 63 63
SH3BP5 -0.005 0.1 -10000 0 -0.44 26 26
PIK3AP1 -0.045 0.16 0.23 11 -0.43 54 65
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.055 0.19 -10000 0 -0.44 71 71
RAF1 -0.02 0.12 -10000 0 -0.32 45 45
RasGAP/p62DOK/SHIP -0.036 0.15 -10000 0 -0.32 79 79
CD79A -0.011 0.084 -10000 0 -0.26 54 54
re-entry into mitotic cell cycle -0.045 0.1 0.18 1 -0.24 72 73
RASA1 0.004 0.078 -10000 0 -0.42 16 16
MAPK3 -0.003 0.1 -10000 0 -0.31 28 28
MAPK1 -0.003 0.1 -10000 0 -0.31 29 29
CD72/SHP1 -0.055 0.19 -10000 0 -0.51 60 60
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
MAPK8 -0.058 0.17 -10000 0 -0.42 61 61
actin cytoskeleton organization -0.049 0.17 -10000 0 -0.44 59 59
NF-kappa-B/RelA 0.043 0.054 0.19 1 -0.23 3 4
Calcineurin -0.023 0.12 -10000 0 -0.34 43 43
PI3K -0.087 0.14 -10000 0 -0.39 74 74
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.043 0.15 0.24 11 -0.4 52 63
SOS1 0.017 0.023 -10000 0 -0.52 1 1
Bam32/HPK1 -0.13 0.31 -10000 0 -0.75 95 95
DAPP1 -0.16 0.35 -10000 0 -0.86 95 95
cytokine secretion -0.037 0.15 -10000 0 -0.35 64 64
mol:DAG -0.041 0.14 0.21 11 -0.36 57 68
PLCG2 -0.017 0.11 -10000 0 -0.32 55 55
MAP2K1 -0.011 0.11 -10000 0 -0.33 32 32
B-cell antigen/BCR complex/FcgammaRIIB -0.045 0.15 -10000 0 -0.32 106 106
mol:PI-3-4-5-P3 -0.058 0.11 0.25 13 -0.29 63 76
ETS1 -0.019 0.12 0.2 10 -0.35 39 49
B-cell antigen/BCR complex/LYN/SYK/BLNK -0.031 0.15 -10000 0 -0.31 86 86
B-cell antigen/BCR complex/LYN -0.077 0.18 -10000 0 -0.51 56 56
MALT1 0.011 0.053 -10000 0 -0.37 9 9
TRAF6 0.017 0.023 -10000 0 -0.52 1 1
RAC1 -0.053 0.18 -10000 0 -0.47 57 57
B-cell antigen/BCR complex/LYN/SYK -0.053 0.19 -10000 0 -0.51 59 59
CARD11 -0.038 0.14 0.21 11 -0.35 64 75
FCGR2B -0.031 0.15 -10000 0 -0.5 50 50
PPP3CA 0.006 0.073 -10000 0 -0.44 13 13
BCL10 0.017 0.012 -10000 0 -0.25 1 1
IKK complex 0.012 0.04 0.11 1 -0.11 8 9
PTPRC -0.04 0.15 -10000 0 -0.41 71 71
PDPK1 -0.017 0.091 0.2 9 -0.21 51 60
PPP3CB 0.016 0.026 -10000 0 -0.39 2 2
PPP3CC -0.001 0.098 -10000 0 -0.51 19 19
POU2F2 0.019 0.021 -10000 0 -0.098 1 1
Caspase cascade in apoptosis

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.002 0.11 0.22 4 -0.26 52 56
ACTA1 -0.03 0.14 0.24 8 -0.33 64 72
NUMA1 -0.005 0.11 0.22 3 -0.26 54 57
SPTAN1 -0.01 0.13 0.24 11 -0.32 55 66
LIMK1 -0.029 0.15 0.23 9 -0.33 78 87
BIRC3 -0.085 0.19 -10000 0 -0.41 128 128
BIRC2 0.016 0.02 -10000 0 -0.25 3 3
BAX 0.016 0.02 -10000 0 -0.25 3 3
CASP10 -0.042 0.13 -10000 0 -0.31 100 100
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
PTK2 -0.003 0.12 0.22 3 -0.27 52 55
DIABLO 0.018 0 -10000 0 -10000 0 0
apoptotic nuclear changes -0.009 0.13 0.23 11 -0.32 55 66
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.01 0.063 -10000 0 -0.49 8 8
GSN -0.019 0.14 0.23 9 -0.33 65 74
MADD 0.018 0 -10000 0 -10000 0 0
TFAP2A -0.009 0.14 -10000 0 -0.56 27 27
BID -0.022 0.089 -10000 0 -0.2 96 96
MAP3K1 -0.029 0.13 -10000 0 -0.41 43 43
TRADD 0.016 0.026 -10000 0 -0.39 2 2
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.022 0.041 -10000 0 -0.37 5 5
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.029 0.14 0.23 5 -0.33 69 74
CASP9 0.017 0.023 -10000 0 -0.52 1 1
DNA repair -0.02 0.075 0.29 8 -0.19 37 45
neuron apoptosis -0.026 0.17 -10000 0 -0.64 36 36
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.005 0.13 0.23 11 -0.3 56 67
APAF1 0.012 0.051 -10000 0 -0.41 7 7
CASP6 0.003 0.11 -10000 0 -0.7 7 7
TRAF2 0.014 0.042 -10000 0 -0.45 4 4
ICAD/CAD -0.003 0.13 0.23 11 -0.31 55 66
CASP7 0.044 0.12 0.29 68 -0.4 11 79
KRT18 -0.071 0.21 -10000 0 -0.57 76 76
apoptosis -0.005 0.13 0.26 8 -0.3 56 64
DFFA -0.01 0.13 0.24 11 -0.32 55 66
DFFB -0.01 0.13 0.24 11 -0.32 55 66
PARP1 0.02 0.075 0.19 37 -0.3 8 45
actin filament polymerization 0.026 0.14 0.3 85 -0.22 9 94
TNF -0.004 0.094 -10000 0 -0.36 31 31
CYCS -0.012 0.062 -10000 0 -0.16 34 34
SATB1 -0.019 0.13 -10000 0 -0.46 23 23
SLK -0.01 0.13 0.24 11 -0.32 56 67
p15 BID/BAX -0.011 0.081 -10000 0 -0.28 11 11
CASP2 0.011 0.089 -10000 0 -0.38 11 11
JNK cascade 0.029 0.13 0.41 43 -10000 0 43
CASP3 -0.017 0.14 0.24 14 -0.34 61 75
LMNB2 0.018 0.068 -10000 0 -0.29 7 7
RIPK1 0.017 0.023 -10000 0 -0.52 1 1
CASP4 -0.005 0.11 -10000 0 -0.49 24 24
Mammalian IAPs/DIABLO -0.024 0.11 -10000 0 -0.28 76 76
negative regulation of DNA binding -0.009 0.14 -10000 0 -0.56 27 27
stress fiber formation -0.01 0.13 0.23 11 -0.32 56 67
GZMB -0.058 0.16 -10000 0 -0.37 98 98
CASP1 -0.038 0.16 -10000 0 -0.42 60 60
LMNB1 -0.032 0.12 -10000 0 -0.29 38 38
APP -0.027 0.17 -10000 0 -0.65 36 36
TNFRSF1A 0.016 0.033 -10000 0 -0.52 2 2
response to stress 0 0 -10000 0 -10000 0 0
CASP8 0.013 0 -10000 0 -10000 0 0
VIM -0.009 0.13 0.26 8 -0.3 56 64
LMNA 0.014 0.076 -10000 0 -0.3 11 11
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.004 0.094 -10000 0 -0.38 13 13
LRDD 0.018 0 -10000 0 -10000 0 0
SREBF1 -0.036 0.15 0.24 10 -0.32 86 96
APAF-1/Caspase 9 0.014 0.068 -10000 0 -0.57 2 2
nuclear fragmentation during apoptosis -0.005 0.11 0.22 3 -0.25 54 57
CFL2 -0.027 0.15 0.22 9 -0.31 85 94
GAS2 -0.035 0.15 0.24 10 -0.32 83 93
positive regulation of apoptosis -0.002 0.08 -10000 0 -0.26 21 21
PRF1 -0.008 0.091 -10000 0 -0.3 43 43
Syndecan-2-mediated signaling events

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin -0.042 0.15 -9999 0 -0.38 76 76
EPHB2 0.007 0.061 -9999 0 -0.32 16 16
Syndecan-2/TACI -0.006 0.092 -9999 0 -0.3 38 38
LAMA1 0.015 0.026 -9999 0 -0.25 5 5
Syndecan-2/alpha2 ITGB1 -0.062 0.17 -9999 0 -0.31 139 139
HRAS 0.012 0.051 -9999 0 -0.41 7 7
Syndecan-2/CASK -0.016 0.089 -9999 0 -0.31 38 38
ITGA5 0.015 0.035 -9999 0 -0.43 3 3
BAX 0.01 0.085 -9999 0 -10000 0 0
EPB41 0.016 0.026 -9999 0 -0.39 2 2
positive regulation of cell-cell adhesion -0.011 0.094 -9999 0 -0.28 49 49
LAMA3 -0.07 0.19 -9999 0 -0.43 103 103
EZR 0 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
CAV2 -0.019 0.12 -9999 0 -0.39 48 48
Syndecan-2/MMP2 -0.033 0.14 -9999 0 -0.38 65 65
RP11-540L11.1 0 0 -9999 0 -10000 0 0
alpha2 ITGB1 -0.024 0.13 -9999 0 -0.37 58 58
dendrite morphogenesis -0.009 0.095 -9999 0 -0.3 42 42
Syndecan-2/GM-CSF -0.014 0.099 -9999 0 -0.31 43 43
determination of left/right symmetry -0.017 0.11 -9999 0 -0.37 38 38
Syndecan-2/PKC delta -0.006 0.094 -9999 0 -0.3 41 41
GNB2L1 0.015 0.04 -9999 0 -0.52 3 3
MAPK3 -0.005 0.09 -9999 0 -0.27 44 44
MAPK1 -0.005 0.092 -9999 0 -0.28 44 44
Syndecan-2/RACK1 0.004 0.087 -9999 0 -0.26 44 44
NF1 0.015 0.035 -9999 0 -0.43 3 3
FGFR/FGF/Syndecan-2 -0.017 0.11 -9999 0 -0.37 38 38
ITGA2 -0.048 0.17 -9999 0 -0.46 73 73
MAPK8 0.001 0.094 -9999 0 -0.3 41 41
Syndecan-2/alpha2/beta1 Integrin -0.018 0.13 -9999 0 -0.3 84 84
Syndecan-2/Kininogen -0.004 0.091 -9999 0 -0.3 38 38
ITGB1 0.014 0.044 -9999 0 -0.41 5 5
SRC 0.007 0.085 -9999 0 -0.25 45 45
Syndecan-2/CASK/Protein 4.1 -0.004 0.083 -9999 0 -0.27 39 39
extracellular matrix organization -0.004 0.091 -9999 0 -0.3 39 39
actin cytoskeleton reorganization -0.042 0.15 -9999 0 -0.38 76 76
Syndecan-2/Caveolin-2/Ras -0.014 0.12 -9999 0 -0.33 55 55
Syndecan-2/Laminin alpha3 -0.055 0.15 -9999 0 -0.34 99 99
Syndecan-2/RasGAP 0.006 0.094 -9999 0 -0.25 52 52
alpha5/beta1 Integrin 0.022 0.041 -9999 0 -0.37 5 5
PRKCD 0.014 0.042 -9999 0 -0.45 4 4
Syndecan-2 dimer -0.009 0.096 -9999 0 -0.3 42 42
GO:0007205 0.004 0.005 -9999 0 -10000 0 0
DNA mediated transformation 0 0 -9999 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.012 0.094 -9999 0 -0.24 53 53
RHOA 0.005 0.08 -9999 0 -0.52 12 12
SDCBP 0.003 0.081 -9999 0 -0.4 19 19
TNFRSF13B 0.013 0.035 -9999 0 -0.25 9 9
RASA1 0.004 0.078 -9999 0 -0.42 16 16
alpha2/beta1 Integrin -0.024 0.13 -9999 0 -0.37 58 58
Syndecan-2/Synbindin -0.003 0.091 -9999 0 -0.3 38 38
TGFB1 0.017 0.023 -9999 0 -0.52 1 1
CASP3 0.003 0.085 -9999 0 -0.27 41 41
FN1 -0.048 0.17 -9999 0 -0.46 73 73
Syndecan-2/IL8 -0.055 0.14 -9999 0 -0.33 87 87
SDC2 -0.017 0.11 -9999 0 -0.37 38 38
KNG1 0.017 0.017 -9999 0 -0.25 2 2
Syndecan-2/Neurofibromin -0.005 0.093 -9999 0 -0.3 40 40
TRAPPC4 0.018 0 -9999 0 -10000 0 0
CSF2 -0.001 0.074 -9999 0 -0.28 33 33
Syndecan-2/TGFB1 -0.004 0.092 -9999 0 -0.3 39 39
Syndecan-2/Syntenin/PI-4-5-P2 -0.011 0.094 -9999 0 -0.28 49 49
Syndecan-2/Ezrin -0.01 0.092 -9999 0 -0.28 50 50
PRKACA 0.004 0.084 -9999 0 -0.27 40 40
angiogenesis -0.055 0.14 -9999 0 -0.33 87 87
MMP2 -0.032 0.15 -9999 0 -0.47 54 54
IL8 -0.072 0.17 -9999 0 -0.34 135 135
calcineurin-NFAT signaling pathway -0.006 0.092 -9999 0 -0.3 38 38
TCGA08_p53

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.037 0.11 -10000 0 -0.23 108 108
TP53 -0.036 0.1 0.28 2 -0.36 37 39
Senescence -0.036 0.1 0.28 2 -0.36 37 39
Apoptosis -0.036 0.1 0.28 2 -0.36 37 39
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.028 0.072 0.24 31 -0.18 13 44
MDM4 0.013 0.044 -10000 0 -0.32 8 8
Signaling events mediated by PTP1B

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.01 0.066 -10000 0 -0.52 8 8
Jak2/Leptin Receptor -0.039 0.12 0.21 1 -0.34 49 50
PTP1B/AKT1 -0.043 0.12 0.29 2 -0.33 45 47
FYN 0.008 0.067 -10000 0 -0.41 12 12
p210 bcr-abl/PTP1B -0.055 0.12 0.32 2 -0.32 63 65
EGFR -0.085 0.18 -10000 0 -0.36 139 139
EGF/EGFR -0.14 0.2 -10000 0 -0.38 184 184
CSF1 0.014 0.037 -10000 0 -0.29 7 7
AKT1 0.011 0.054 -10000 0 -0.38 9 9
INSR 0.015 0.037 -10000 0 -0.39 4 4
PTP1B/N-cadherin -0.065 0.15 0.28 2 -0.35 72 74
Insulin Receptor/Insulin -0.02 0.1 -10000 0 -0.34 23 23
HCK -0.005 0.11 -10000 0 -0.47 25 25
CRK 0.016 0.033 -10000 0 -0.52 2 2
TYK2 -0.046 0.12 0.3 2 -0.32 55 57
EGF -0.15 0.23 -10000 0 -0.43 193 193
YES1 0.007 0.07 -10000 0 -0.43 12 12
CAV1 -0.074 0.14 0.29 2 -0.37 62 64
TXN 0.013 0.017 -10000 0 -0.26 2 2
PTP1B/IRS1/GRB2 -0.067 0.15 -10000 0 -0.35 89 89
cell migration 0.055 0.12 0.32 63 -0.32 2 65
STAT3 0.014 0.041 -10000 0 -0.52 3 3
PRLR -0.027 0.15 -10000 0 -0.49 50 50
ITGA2B 0.015 0.02 -10000 0 -0.25 3 3
CSF1R 0.017 0.017 -10000 0 -0.25 2 2
Prolactin Receptor/Prolactin -0.002 0.12 -10000 0 -0.36 47 47
FGR 0.017 0.017 -10000 0 -0.25 2 2
PTP1B/p130 Cas -0.044 0.12 0.28 2 -0.32 55 57
Crk/p130 Cas -0.036 0.12 -10000 0 -0.33 42 42
DOK1 -0.039 0.13 0.3 2 -0.38 40 42
JAK2 -0.037 0.12 -10000 0 -0.35 41 41
Jak2/Leptin Receptor/Leptin -0.069 0.13 -10000 0 -0.36 53 53
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
PTPN1 -0.056 0.12 0.32 2 -0.33 63 65
LYN 0.014 0.031 -10000 0 -0.25 7 7
CDH2 -0.027 0.13 -10000 0 -0.34 66 66
SRC -0.005 0.07 -10000 0 -0.68 3 3
ITGB3 0.001 0.076 -10000 0 -0.32 25 25
CAT1/PTP1B -0.085 0.17 0.27 1 -0.44 65 66
CAPN1 0.003 0.078 -10000 0 -0.44 15 15
CSK 0.015 0.031 -10000 0 -0.32 4 4
PI3K -0.036 0.1 -10000 0 -0.35 30 30
mol:H2O2 -0.003 0.005 -10000 0 -10000 0 0
STAT3 (dimer) -0.062 0.12 -10000 0 -0.38 40 40
negative regulation of transcription -0.037 0.11 -10000 0 -0.35 41 41
FCGR2A -0.003 0.099 -10000 0 -0.45 23 23
FER 0.013 0.027 -10000 0 -0.4 2 2
alphaIIb/beta3 Integrin 0.011 0.056 -10000 0 -0.37 7 7
BLK -0.019 0.1 -10000 0 -0.29 63 63
Insulin Receptor/Insulin/Shc 0.032 0.032 -10000 0 -0.31 4 4
RHOA 0.004 0.081 -10000 0 -0.53 12 12
LEPR -0.005 0.093 -10000 0 -0.34 34 34
BCAR1 0.017 0.012 -10000 0 -0.25 1 1
p210 bcr-abl/Grb2 0.016 0.023 -10000 0 -0.25 4 4
mol:NADPH -0.003 0.004 -10000 0 -10000 0 0
TRPV6 -0.06 0.16 -10000 0 -0.44 54 54
PRL 0.018 0.033 -10000 0 -0.32 4 4
SOCS3 -0.005 0.17 -10000 0 -1.3 8 8
SPRY2 -0.036 0.15 -10000 0 -0.43 60 60
Insulin Receptor/Insulin/IRS1 -0.008 0.12 -10000 0 -0.32 62 62
CSF1/CSF1R -0.037 0.12 -10000 0 -0.34 39 39
Ras protein signal transduction 0.029 0.039 -10000 0 -0.19 3 3
IRS1 -0.048 0.17 -10000 0 -0.49 68 68
INS 0.017 0.024 -10000 0 -0.53 1 1
LEP -0.051 0.15 -10000 0 -0.34 101 101
STAT5B -0.043 0.11 0.25 2 -0.28 64 66
STAT5A -0.044 0.11 0.25 2 -0.28 65 67
GRB2 0.016 0.024 -10000 0 -0.25 4 4
PDGFB-D/PDGFRB -0.048 0.13 0.28 2 -0.36 55 57
CSN2 0.02 0.1 -10000 0 -1.4 2 2
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
LAT -0.025 0.12 -10000 0 -0.55 19 19
YBX1 0.007 0.072 -10000 0 -0.33 16 16
LCK -0.074 0.18 -10000 0 -0.4 117 117
SHC1 0.017 0.023 -10000 0 -0.52 1 1
NOX4 -0.059 0.18 -10000 0 -0.49 78 78
Integrins in angiogenesis

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.01 0.064 -9999 0 -0.37 9 9
alphaV beta3 Integrin -0.034 0.13 -9999 0 -0.33 62 62
PTK2 -0.008 0.14 -9999 0 -0.48 25 25
IGF1R -0.083 0.2 -9999 0 -0.47 110 110
PI4KB 0.016 0.033 -9999 0 -0.52 2 2
MFGE8 -0.018 0.12 -9999 0 -0.36 50 50
SRC 0.015 0.035 -9999 0 -0.43 3 3
CDKN1B -0.022 0.13 -9999 0 -0.48 30 30
VEGFA 0 0.075 -9999 0 -0.29 31 31
ILK 0.002 0.072 -9999 0 -0.75 2 2
ROCK1 0.018 0 -9999 0 -10000 0 0
AKT1 0.007 0.075 -9999 0 -0.49 5 5
PTK2B 0.012 0.091 -9999 0 -0.32 27 27
alphaV/beta3 Integrin/JAM-A -0.014 0.12 -9999 0 -0.28 60 60
CBL 0.017 0.012 -9999 0 -0.25 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 0.01 0.087 -9999 0 -0.33 27 27
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.11 0.22 -9999 0 -0.39 169 169
VEGF/Rho/ROCK/alphaV/beta3 Integrin 0.021 0.086 -9999 0 -0.37 14 14
alphaV/beta3 Integrin/Syndecan-1 -0.02 0.13 -9999 0 -0.33 67 67
PI4KA 0.018 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.18 0.24 -9999 0 -0.53 131 131
PI4 Kinase 0.025 0.024 -9999 0 -0.37 2 2
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
alphaV/beta3 Integrin/Osteopontin -0.082 0.16 -9999 0 -0.33 141 141
RPS6KB1 -0.15 0.23 -9999 0 -0.49 135 135
TLN1 0.017 0.023 -9999 0 -0.52 1 1
MAPK3 -0.092 0.22 -9999 0 -0.65 57 57
GPR124 0 0.095 -9999 0 -0.52 17 17
MAPK1 -0.092 0.22 -9999 0 -0.65 57 57
PXN 0.018 0 -9999 0 -10000 0 0
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
alphaV/beta3 Integrin/Tumstatin 0.011 0.087 -9999 0 -0.35 24 24
cell adhesion -0.008 0.12 -9999 0 -0.42 24 24
ANGPTL3 0.011 0.056 -9999 0 -0.42 8 8
VEGFR2 homodimer/VEGFA homodimer/Src 0.021 0.059 -9999 0 -0.3 11 11
IGF-1R heterotetramer -0.083 0.2 -9999 0 -0.47 110 110
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
TGFBR2 0.013 0.049 -9999 0 -0.43 6 6
ITGB3 0.002 0.075 -9999 0 -0.32 25 25
IGF1 -0.1 0.2 -9999 0 -0.41 146 146
RAC1 0.018 0 -9999 0 -10000 0 0
regulation of cell-matrix adhesion 0.004 0.11 -9999 0 -0.38 33 33
apoptosis -0.002 0.099 -9999 0 -0.48 21 21
CD47 -0.005 0.11 -9999 0 -0.47 25 25
alphaV/beta3 Integrin/CD47 0 0.1 -9999 0 -0.32 42 42
VCL 0.016 0.029 -9999 0 -0.34 3 3
alphaV/beta3 Integrin/Del1 -0.066 0.17 -9999 0 -0.35 115 115
CSF1 0.014 0.037 -9999 0 -0.29 7 7
PIK3C2A -0.003 0.096 -9999 0 -0.74 6 6
PI4 Kinase/Pyk2 -0.042 0.092 -9999 0 -0.4 18 18
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.013 0.099 -9999 0 -0.34 29 29
FAK1/Vinculin 0.004 0.11 -9999 0 -0.38 24 24
alphaV beta3/Integrin/ppsTEM5 0.004 0.11 -9999 0 -0.38 33 33
RHOA 0.005 0.08 -9999 0 -0.52 12 12
VTN 0.016 0.02 -9999 0 -0.25 3 3
BCAR1 0.017 0.012 -9999 0 -0.25 1 1
FGF2 -0.064 0.16 -9999 0 -0.34 122 122
F11R -0.037 0.12 -9999 0 -0.37 41 41
alphaV/beta3 Integrin/Lactadherin -0.006 0.12 -9999 0 -0.39 38 38
alphaV/beta3 Integrin/TGFBR2 0.011 0.089 -9999 0 -0.35 26 26
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.031 0.062 -9999 0 -0.27 19 19
HSP90AA1 0.013 0.045 -9999 0 -0.39 6 6
alphaV/beta3 Integrin/Talin 0.014 0.075 -9999 0 -0.31 23 23
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.048 0.17 -9999 0 -0.46 73 73
alphaV/beta3 Integrin/Pyk2 0.018 0.094 -9999 0 -0.32 27 27
SDC1 -0.038 0.16 -9999 0 -0.46 62 62
VAV3 -0.024 0.13 -9999 0 -0.27 102 102
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
IRS1 -0.048 0.17 -9999 0 -0.49 68 68
FAK1/Paxillin 0.004 0.11 -9999 0 -0.38 22 22
cell migration 0.011 0.1 -9999 0 -0.38 15 15
ITGAV -0.002 0.1 -9999 0 -0.48 21 21
PI3K -0.016 0.12 -9999 0 -0.41 22 22
SPP1 -0.14 0.23 -9999 0 -0.43 188 188
KDR 0.013 0.052 -9999 0 -0.52 5 5
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 -0.002 0.099 -9999 0 -0.48 21 21
COL4A3 0.013 0.047 -9999 0 -0.37 7 7
angiogenesis -0.081 0.22 -9999 0 -0.65 56 56
Rac1/GTP -0.013 0.12 -9999 0 -0.42 11 11
EDIL3 -0.11 0.22 -9999 0 -0.44 152 152
cell proliferation 0.011 0.089 -9999 0 -0.34 26 26
Canonical Wnt signaling pathway

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.035 0.05 0.21 4 -0.53 1 5
AES 0.033 0.037 0.2 3 -10000 0 3
FBXW11 0.015 0.035 -10000 0 -0.43 3 3
mol:GTP 0.001 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.009 0.076 -10000 0 -0.36 19 19
SMAD4 0.009 0.067 -10000 0 -0.49 9 9
DKK2 -0.026 0.14 -10000 0 -0.42 52 52
TLE1 -0.017 0.16 0.2 2 -0.45 55 57
MACF1 0.016 0.026 -10000 0 -0.39 2 2
CTNNB1 -0.006 0.098 0.28 2 -0.35 15 17
WIF1 -0.024 0.098 -10000 0 -0.25 81 81
beta catenin/RanBP3 0.069 0.19 0.38 114 -0.46 2 116
KREMEN2 -0.19 0.23 -10000 0 -0.41 257 257
DKK1 -0.12 0.19 -10000 0 -0.34 199 199
beta catenin/beta TrCP1 0.005 0.096 0.27 2 -0.35 13 15
FZD1 0.003 0.082 -10000 0 -0.43 17 17
AXIN2 -0.097 0.33 -10000 0 -1.3 31 31
AXIN1 0.017 0.012 -10000 0 -0.25 1 1
RAN 0.018 0.012 -10000 0 -0.25 1 1
Axin1/APC/GSK3/beta catenin 0.034 0.036 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.017 0.16 -10000 0 -0.43 35 35
Axin1/APC/GSK3 0.049 0.042 0.24 4 -10000 0 4
Axin1/APC/GSK3/beta catenin/Macf1 0.037 0.067 -10000 0 -0.3 2 2
HNF1A 0.031 0.044 0.2 1 -0.24 3 4
CTBP1 0.033 0.041 0.21 2 -0.26 1 3
MYC -0.12 0.36 -10000 0 -1.2 44 44
RANBP3 0.018 0.001 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.12 0.16 -10000 0 -0.33 186 186
NKD1 0.009 0.059 -10000 0 -0.38 11 11
TCF4 0.008 0.12 0.2 2 -0.49 26 28
TCF3 0.029 0.057 0.18 9 -0.29 8 17
WNT1/LRP6/FZD1/Axin1 0.031 0.062 -10000 0 -0.27 20 20
Ran/GTP 0.014 0.009 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.098 0.25 0.5 120 -0.48 8 128
LEF1 -0.007 0.13 0.2 4 -0.31 64 68
DVL1 0.045 0.042 -10000 0 -0.31 3 3
CSNK2A1 0.017 0.023 -10000 0 -0.52 1 1
beta catenin/TCF/CtBP/CBP/TLE1/AES -0.038 0.17 -10000 0 -0.49 35 35
DKK1/LRP6/Kremen 2 -0.17 0.17 -10000 0 -0.33 249 249
LRP6 0.008 0.065 -10000 0 -0.38 13 13
CSNK1A1 0.035 0.048 0.19 17 -0.46 1 18
NLK 0.008 0.044 -10000 0 -0.28 11 11
CCND1 -0.25 0.54 -10000 0 -1.4 87 87
WNT1 0.016 0.023 -10000 0 -0.52 1 1
GSK3A 0.018 0.001 -10000 0 -10000 0 0
GSK3B 0.017 0.001 -10000 0 -10000 0 0
FRAT1 0.008 0.068 -10000 0 -0.47 10 10
PPP2R5D 0.028 0.035 0.26 5 -10000 0 5
APC 0.026 0.062 -10000 0 -0.24 23 23
WNT1/LRP6/FZD1 0.037 0.06 -10000 0 -0.23 11 11
CREBBP 0.032 0.051 0.21 2 -0.52 2 4
Calcium signaling in the CD4+ TCR pathway

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.002 0.077 -9999 0 -0.3 26 26
NFATC2 0.013 0.043 -9999 0 -0.3 5 5
NFATC3 0.015 0.03 -9999 0 -10000 0 0
CD40LG -0.097 0.25 -9999 0 -0.55 86 86
PTGS2 -0.11 0.26 -9999 0 -0.55 93 93
JUNB 0.011 0.055 -9999 0 -0.36 10 10
CaM/Ca2+/Calcineurin A alpha-beta B1 0.008 0.018 -9999 0 -10000 0 0
CaM/Ca2+ 0.008 0.018 -9999 0 -10000 0 0
CALM1 0.016 0.009 -9999 0 -10000 0 0
JUN -0.035 0.15 -9999 0 -0.46 57 57
mol:Ca2+ -0.004 0.011 -9999 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.011 0.011 -9999 0 -0.14 2 2
FOSL1 0.016 0.024 -9999 0 -0.25 4 4
CREM 0.016 0.017 -9999 0 -0.26 2 2
Jun/NFAT1-c-4/p21SNFT -0.024 0.15 -9999 0 -0.35 53 53
FOS -0.11 0.2 -9999 0 -0.37 171 171
IFNG -0.14 0.3 -9999 0 -0.6 115 115
AP-1/NFAT1-c-4 -0.1 0.3 -9999 0 -0.62 95 95
FASLG -0.12 0.3 -9999 0 -0.61 110 110
NFAT1-c-4/ICER1 0.008 0.095 -9999 0 -0.31 14 14
IL2RA -0.11 0.28 -9999 0 -0.56 106 106
FKBP12/FK506 0.012 0.011 -9999 0 -0.17 2 2
CSF2 -0.099 0.26 -9999 0 -0.55 90 90
JunB/Fra1/NFAT1-c-4 0.016 0.1 -9999 0 -0.33 14 14
IL4 -0.095 0.25 -9999 0 -0.54 86 86
IL2 -0.005 0.1 -9999 0 -1.3 3 3
IL3 0.008 0.021 -9999 0 -10000 0 0
FKBP1A 0.017 0.017 -9999 0 -0.25 2 2
BATF3 0 0 -9999 0 -10000 0 0
mol:FK506 0 0 -9999 0 -10000 0 0
POU2F1 0.026 0 -9999 0 -10000 0 0
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.002 0.07 -9999 0 -0.28 28 28
Caspase 8 (4 units) -0.034 0.14 -9999 0 -0.39 37 37
NEF -0.014 0.042 -9999 0 -0.18 10 10
NFKBIA -0.004 0.061 -9999 0 -0.52 4 4
BIRC3 -0.064 0.21 -9999 0 -0.55 74 74
CYCS -0.04 0.14 -9999 0 -0.4 38 38
RIPK1 0.017 0.023 -9999 0 -0.52 1 1
CD247 -0.13 0.24 -9999 0 -0.47 153 153
MAP2K7 -0.023 0.13 -9999 0 -0.53 14 14
protein ubiquitination 0.018 0.095 -9999 0 -0.34 12 12
CRADD 0.01 0.063 -9999 0 -0.49 8 8
DAXX 0.017 0.012 -9999 0 -0.25 1 1
FAS -0.024 0.13 -9999 0 -0.42 51 51
BID -0.048 0.14 -9999 0 -0.33 77 77
NF-kappa-B/RelA/I kappa B alpha -0.014 0.12 -9999 0 -0.27 76 76
TRADD 0.016 0.026 -9999 0 -0.39 2 2
MAP3K5 -0.022 0.13 -9999 0 -0.42 47 47
CFLAR 0.009 0.065 -9999 0 -0.44 10 10
FADD 0 0.067 -9999 0 -0.25 35 35
NF-kappa-B/RelA/I kappa B alpha/ubiquitin -0.014 0.12 -9999 0 -0.27 76 76
MAPK8 -0.016 0.12 -9999 0 -0.55 11 11
APAF1 0.012 0.051 -9999 0 -0.41 7 7
TRAF1 0.013 0.04 -9999 0 -0.28 9 9
TRAF2 0.014 0.042 -9999 0 -0.45 4 4
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.052 0.15 -9999 0 -0.32 91 91
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.01 0.1 -9999 0 -0.43 9 9
CHUK 0.017 0.1 -9999 0 -0.37 12 12
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0 0.11 -9999 0 -0.29 55 55
TCRz/NEF -0.11 0.21 -9999 0 -0.43 133 133
TNF -0.004 0.094 -9999 0 -0.36 31 31
FASLG -0.12 0.26 -9999 0 -0.46 157 157
NFKB1 -0.001 0.046 -9999 0 -0.52 1 1
TNFR1A/BAG4/TNF-alpha 0.012 0.074 -9999 0 -0.31 18 18
CASP6 -0.02 0.14 -9999 0 -0.55 18 18
CASP7 -0.072 0.23 -9999 0 -0.54 80 80
RELA 0 0.04 -9999 0 -10000 0 0
CASP2 0.018 0 -9999 0 -10000 0 0
CASP3 -0.066 0.22 -9999 0 -0.54 78 78
TNFRSF1A 0.016 0.033 -9999 0 -0.52 2 2
TNFR1A/BAG4 0.014 0.054 -9999 0 -0.37 5 5
CASP8 0.018 0 -9999 0 -10000 0 0
CASP9 0.017 0.023 -9999 0 -0.52 1 1
MAP3K14 0.015 0.1 -9999 0 -0.43 9 9
APAF-1/Caspase 9 -0.097 0.15 -9999 0 -0.4 87 87
BCL2 -0.066 0.15 -9999 0 -0.44 35 35
Visual signal transduction: Rods

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.011 0.056 -9999 0 -0.42 8 8
GNAT1/GTP 0.01 0.035 -9999 0 -0.34 5 5
Metarhodopsin II/Arrestin -0.045 0.12 -9999 0 -0.31 64 64
PDE6G/GNAT1/GTP 0.02 0.033 -9999 0 -0.31 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
GNAT1 0.013 0.048 -9999 0 -0.47 5 5
GRK1 0 0 -9999 0 -10000 0 0
CNG Channel -0.082 0.12 -9999 0 -0.36 46 46
mol:Na + -0.04 0.088 -9999 0 -0.43 14 14
mol:ADP 0 0 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.056 0.15 -9999 0 -0.34 96 96
mol:GDP 0 0 -9999 0 -10000 0 0
cGMP/CNG Channel -0.002 0.11 -9999 0 -0.44 14 14
CNGB1 0.018 0 -9999 0 -10000 0 0
RDH5 -0.003 0.072 -9999 0 -0.25 40 40
SAG -0.098 0.19 -9999 0 -0.36 162 162
mol:Ca2+ 0.001 0.11 -9999 0 -0.39 17 17
Na + (4 Units) -0.039 0.085 -9999 0 -0.38 17 17
RGS9 -0.033 0.13 -9999 0 -0.31 81 81
GNB1/GNGT1 -0.033 0.1 -9999 0 -0.37 18 18
GNAT1/GDP -0.04 0.13 -9999 0 -0.29 99 99
GUCY2D 0.018 0 -9999 0 -10000 0 0
GNGT1 -0.063 0.14 -9999 0 -0.28 144 144
GUCY2F 0.006 0.076 -9999 0 -0.46 13 13
GNB5 0.005 0.081 -9999 0 -0.5 13 13
mol:GMP (4 units) -0.034 0.12 -9999 0 -0.26 118 118
mol:11-cis-retinal -0.003 0.072 -9999 0 -0.25 40 40
mol:cGMP 0.026 0.087 -9999 0 -0.3 30 30
GNB1 0.013 0.052 -9999 0 -0.52 5 5
Rhodopsin 0.012 0.049 -9999 0 -10000 0 0
SLC24A1 0.011 0.056 -9999 0 -0.42 8 8
CNGA1 -0.061 0.15 -9999 0 -0.32 123 123
Metarhodopsin II 0.011 0 -9999 0 -10000 0 0
mol:Ca ++ 0 0 -9999 0 -10000 0 0
GC1/GCAP Family 0.027 0.075 -9999 0 -0.29 24 24
RGS9BP -0.072 0.18 -9999 0 -0.41 111 111
Metarhodopsin II/Transducin -0.005 0.064 -9999 0 -0.25 22 22
GCAP Family/Ca ++ 0.016 0.074 -9999 0 -0.3 24 24
PDE6A/B -0.066 0.17 -9999 0 -0.37 115 115
mol:Pi -0.056 0.15 -9999 0 -0.34 96 96
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
Transducin -0.014 0.083 -9999 0 -0.29 22 22
PDE6B -0.1 0.22 -9999 0 -0.5 123 123
PDE6A 0.011 0.048 -9999 0 -0.3 11 11
PDE6G 0.016 0.024 -9999 0 -0.25 4 4
RHO 0.018 0 -9999 0 -10000 0 0
PDE6 -0.088 0.17 -9999 0 -0.41 63 63
GUCA1A 0.001 0.092 -9999 0 -0.48 18 18
GC2/GCAP Family 0.02 0.092 -9999 0 -0.32 30 30
GUCA1C 0.005 0.078 -9999 0 -0.43 15 15
GUCA1B 0.014 0.035 -9999 0 -0.3 6 6
Ras signaling in the CD4+ TCR pathway

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.034 0.14 -9999 0 -0.33 76 76
MAP3K8 -0.038 0.15 -9999 0 -0.39 70 70
FOS -0.014 0.092 -9999 0 -0.28 16 16
PRKCA 0.01 0.034 -9999 0 -0.26 8 8
PTPN7 0.006 0.049 -9999 0 -0.28 14 14
HRAS 0.011 0.051 -9999 0 -0.41 7 7
PRKCB -0.003 0.007 -9999 0 -0.013 171 171
NRAS 0.004 0.076 -9999 0 -0.41 16 16
RAS family/GTP 0.013 0.064 -9999 0 -0.28 20 20
MAPK3 0.002 0.057 -9999 0 -0.45 2 2
MAP2K1 -0.005 0.064 -9999 0 -0.22 16 16
ELK1 0.01 0.038 -9999 0 -0.39 4 4
BRAF 0.004 0.057 -9999 0 -0.41 7 7
mol:GTP -0.001 0.002 -9999 0 -0.004 171 171
MAPK1 0.001 0.06 -9999 0 -0.43 3 3
RAF1 0.011 0.028 -9999 0 -10000 0 0
KRAS 0.008 0.065 -9999 0 -0.44 10 10
IL1-mediated signaling events

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.012 0.011 -9999 0 -0.17 2 2
PRKCZ 0 0 -9999 0 -10000 0 0
MAP3K7IP2 0.014 0.047 -9999 0 -0.52 4 4
ERC1 0.011 0.056 -9999 0 -0.42 8 8
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.024 0.11 -9999 0 -0.32 40 40
IRAK/TOLLIP 0.029 0.019 -9999 0 -0.23 1 1
IKBKB 0.012 0.047 -9999 0 -0.31 10 10
IKBKG 0.018 0 -9999 0 -10000 0 0
IL1 alpha/IL1R2 -0.025 0.12 -9999 0 -0.36 46 46
IL1A 0.006 0.063 -9999 0 -0.31 18 18
IL1B -0.067 0.18 -9999 0 -0.43 86 86
IRAK/TRAF6/p62/Atypical PKCs 0.031 0.053 -9999 0 -0.23 18 18
IL1R2 -0.045 0.15 -9999 0 -0.35 89 89
IL1R1 -0.046 0.16 -9999 0 -0.4 80 80
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.018 0.12 -9999 0 -0.29 61 61
TOLLIP 0.017 0.012 -9999 0 -0.25 1 1
TICAM2 0 0 -9999 0 -10000 0 0
MAP3K3 0.017 0.012 -9999 0 -0.25 1 1
TAK1/TAB1/TAB2 0.033 0.034 -9999 0 -0.34 4 4
IKK complex/ELKS 0.051 0.075 -9999 0 -0.45 3 3
JUN 0.014 0.093 -9999 0 -0.44 4 4
MAP3K7 0.016 0.02 -9999 0 -0.25 3 3
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.059 0.18 -9999 0 -0.34 120 120
IL1 alpha/IL1R1/IL1RAP/MYD88 -0.002 0.1 -9999 0 -0.28 57 57
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.005 0.1 -9999 0 -0.26 57 57
IL1 beta fragment/IL1R1/IL1RAP -0.069 0.18 -9999 0 -0.36 120 120
NFKB1 0.017 0.023 -9999 0 -0.52 1 1
MAPK8 0.032 0.063 -9999 0 -0.37 2 2
IRAK1 0.019 0.018 -9999 0 -10000 0 0
IL1RN/IL1R1 -0.061 0.17 -9999 0 -0.41 87 87
IRAK4 0.014 0.044 -9999 0 -0.41 5 5
PRKCI 0.002 0.085 -9999 0 -0.43 18 18
TRAF6 0.017 0.023 -9999 0 -0.52 1 1
PI3K 0.005 0.082 -9999 0 -0.37 21 21
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.032 0.13 -9999 0 -0.36 47 47
CHUK 0.005 0.081 -9999 0 -0.5 13 13
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.069 0.18 -9999 0 -0.36 120 120
IL1 beta/IL1R2 -0.082 0.18 -9999 0 -0.36 128 128
IRAK/TRAF6/TAK1/TAB1/TAB2 0.048 0.033 -9999 0 -0.33 1 1
NF kappa B1 p50/RelA -0.082 0.14 -9999 0 -0.44 54 54
IRAK3 -0.018 0.099 -9999 0 -0.28 64 64
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.056 0.17 -9999 0 -0.34 110 110
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.004 0.089 -9999 0 -0.23 57 57
IL1 alpha/IL1R1/IL1RAP -0.013 0.11 -9999 0 -0.31 53 53
RELA 0.018 0 -9999 0 -10000 0 0
MAP3K7IP1 0.018 0 -9999 0 -10000 0 0
SQSTM1 0.012 0.053 -9999 0 -0.48 6 6
MYD88 0.013 0.048 -9999 0 -0.47 5 5
IRAK/TRAF6/MEKK3 0.038 0.021 -9999 0 -0.25 1 1
IL1RAP 0.012 0.044 -9999 0 -0.28 11 11
UBE2N 0.017 0.017 -9999 0 -0.25 2 2
IRAK/TRAF6 -0.069 0.12 -9999 0 -0.39 49 49
CASP1 -0.051 0.17 -9999 0 -0.42 84 84
IL1RN/IL1R2 -0.06 0.16 -9999 0 -0.39 82 82
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.057 0.17 -9999 0 -0.35 111 111
TMEM189-UBE2V1 0 0 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.003 0.1 -9999 0 -0.3 50 50
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
IL1RN -0.043 0.16 -9999 0 -0.4 76 76
TRAF6/TAK1/TAB1/TAB2 0.04 0.031 -9999 0 -0.26 5 5
MAP2K6 0.028 0.063 -9999 0 -0.4 2 2
Glypican 2 network

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK -0.016 0.12 -9999 0 -0.37 46 46
GPC2 0 0 -9999 0 -10000 0 0
GPC2/Midkine -0.011 0.083 -9999 0 -0.26 46 46
neuron projection morphogenesis -0.011 0.083 -9999 0 -0.26 46 46
Coregulation of Androgen receptor activity

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 -0.042 0.16 -9999 0 -0.46 67 67
SVIL -0.004 0.1 -9999 0 -0.43 27 27
ZNF318 0.014 0.005 -9999 0 -10000 0 0
JMJD2C 0.023 0.032 -9999 0 -0.32 4 4
T-DHT/AR/Ubc9 -0.065 0.14 -9999 0 -0.33 103 103
CARM1 0.014 0.039 -9999 0 -0.36 5 5
PRDX1 0.012 0.05 -9999 0 -0.43 6 6
PELP1 0.017 0.001 -9999 0 -10000 0 0
CTNNB1 0.002 0.09 -9999 0 -0.45 19 19
AKT1 0.01 0.053 -9999 0 -0.37 9 9
PTK2B 0.017 0.017 -9999 0 -0.25 2 2
MED1 -0.001 0.066 -9999 0 -0.25 34 34
MAK -0.018 0.094 -9999 0 -0.28 57 57
response to oxidative stress 0 0 -9999 0 -10000 0 0
HIP1 0.019 0.012 -9999 0 -0.25 1 1
GSN 0 0.095 -9999 0 -0.43 23 23
NCOA2 0.009 0.063 -9999 0 -0.4 11 11
NCOA6 0.019 0.012 -9999 0 -0.25 1 1
DNA-PK 0.029 0.029 -9999 0 -0.31 2 2
NCOA4 0.008 0.069 -9999 0 -0.45 11 11
PIAS3 0.019 0.002 -9999 0 -10000 0 0
cell proliferation -0.043 0.092 -9999 0 -0.57 9 9
XRCC5 0.017 0.001 -9999 0 -10000 0 0
UBE3A 0.018 0.033 -9999 0 -0.52 2 2
T-DHT/AR/SNURF -0.076 0.14 -9999 0 -0.32 118 118
FHL2 -0.15 0.34 -9999 0 -0.97 70 70
RANBP9 0.019 0.012 -9999 0 -0.25 1 1
JMJD1A -0.002 0.055 -9999 0 -10000 0 0
CDK6 -0.019 0.1 -9999 0 -0.29 63 63
TGFB1I1 -0.003 0.1 -9999 0 -0.48 23 23
T-DHT/AR/CyclinD1 -0.12 0.21 -9999 0 -0.43 149 149
XRCC6 0.016 0.012 -9999 0 -0.26 1 1
T-DHT/AR -0.085 0.17 -9999 0 -0.33 138 138
CTDSP1 0.016 0.033 -9999 0 -0.52 2 2
CTDSP2 0.011 0.044 -9999 0 -0.42 5 5
BRCA1 0.001 0.094 -9999 0 -0.48 19 19
TCF4 -0.01 0.12 -9999 0 -0.51 26 26
CDKN2A -0.055 0.15 -9999 0 -0.33 108 108
SRF 0 0.054 -9999 0 -0.28 4 4
NKX3-1 -0.056 0.11 -9999 0 -0.24 105 105
KLK3 0.022 0.055 -9999 0 -10000 0 0
TMF1 0.018 0.001 -9999 0 -10000 0 0
HNRNPA1 0.015 0.023 -9999 0 -0.52 1 1
AOF2 0.018 0.026 -9999 0 -0.39 2 2
APPL1 0.015 0.054 -9999 0 -0.37 9 9
T-DHT/AR/Caspase 8 -0.066 0.14 -9999 0 -0.33 103 103
AR -0.11 0.21 -9999 0 -0.53 104 104
UBA3 0 0.001 -9999 0 -10000 0 0
PATZ1 0.003 0.084 -9999 0 -0.5 14 14
PAWR 0.001 0.091 -9999 0 -0.44 20 20
PRKDC 0.011 0.045 -9999 0 -0.31 9 9
PA2G4 0.016 0.012 -9999 0 -0.26 1 1
UBE2I 0.018 0 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 -0.059 0.13 -9999 0 -0.3 103 103
RPS6KA3 0.011 0.057 -9999 0 -0.34 12 12
T-DHT/AR/ARA70 -0.071 0.15 -9999 0 -0.34 109 109
LATS2 0.004 0.078 -9999 0 -0.48 13 13
T-DHT/AR/PRX1 -0.062 0.13 -9999 0 -0.31 106 106
Cyclin D3/CDK11 p58 0.013 0.008 -9999 0 -0.17 1 1
VAV3 -0.082 0.2 -9999 0 -0.48 108 108
KLK2 -0.013 0.075 -9999 0 -0.4 1 1
CASP8 0.017 0.001 -9999 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 -0.054 0.14 -9999 0 -0.3 111 111
TMPRSS2 -0.18 0.38 -9999 0 -0.91 105 105
CCND1 -0.089 0.2 -9999 0 -0.44 124 124
PIAS1 0.019 0.012 -9999 0 -0.25 1 1
mol:T-DHT -0.018 0.037 -9999 0 -0.077 130 130
CDC2L1 0 0 -9999 0 -10000 0 0
PIAS4 0.016 0.05 -9999 0 -0.43 6 6
T-DHT/AR/CDK6 -0.085 0.17 -9999 0 -0.37 118 118
CMTM2 0.016 0.023 -9999 0 -0.52 1 1
SNURF 0 0 -9999 0 -10000 0 0
ZMIZ1 -0.003 0.049 -9999 0 -0.31 6 6
CCND3 0.017 0.012 -9999 0 -0.25 1 1
TGIF1 0.006 0.073 -9999 0 -0.52 10 10
FKBP4 0.013 0.055 -9999 0 -0.44 7 7
Glypican 1 network

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer -0.045 0.14 -10000 0 -0.37 67 67
fibroblast growth factor receptor signaling pathway -0.045 0.14 -10000 0 -0.36 67 67
LAMA1 0.015 0.026 -10000 0 -0.25 5 5
PRNP 0.006 0.073 -10000 0 -0.44 13 13
GPC1/SLIT2 -0.025 0.14 -10000 0 -0.39 60 60
SMAD2 0.012 0.084 -10000 0 -0.28 36 36
GPC1/PrPc/Cu2+ 0.002 0.083 -10000 0 -0.33 30 30
GPC1/Laminin alpha1 0.007 0.082 -10000 0 -0.37 22 22
TDGF1 0.017 0.012 -10000 0 -0.25 1 1
CRIPTO/GPC1 0.009 0.08 -10000 0 -0.37 22 22
APP/GPC1 -0.025 0.13 -10000 0 -0.38 57 57
mol:NO 0 0 -10000 0 -10000 0 0
YES1 0.01 0.081 -10000 0 -0.31 30 30
FLT1 0.004 0.08 -10000 0 -0.45 15 15
GPC1/TGFB/TGFBR1/TGFBR2 0.009 0.093 -10000 0 -0.32 35 35
SERPINC1 0.007 0.054 -10000 0 -0.27 19 19
FYN 0.01 0.079 -10000 0 -0.31 29 29
FGR 0.015 0.068 -10000 0 -0.3 22 22
positive regulation of MAPKKK cascade -0.012 0.12 -10000 0 -0.39 32 32
SLIT2 -0.029 0.15 -10000 0 -0.48 50 50
GPC1/NRG 0.002 0.089 -10000 0 -0.38 23 23
NRG1 0.008 0.053 -10000 0 -0.27 18 18
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.002 0.097 -10000 0 -0.32 37 37
LYN 0.014 0.071 -10000 0 -0.31 22 22
mol:Spermine -0.005 0.079 -10000 0 -0.38 22 22
cell growth -0.045 0.14 -10000 0 -0.36 67 67
BMP signaling pathway 0.006 0.11 0.49 25 -10000 0 25
SRC 0.015 0.073 -10000 0 -0.32 23 23
TGFBR1 0.003 0.082 -10000 0 -0.42 18 18
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.054 0.14 -10000 0 -0.3 122 122
GPC1 -0.006 0.11 -10000 0 -0.49 25 25
TGFBR1 (dimer) 0.003 0.082 -10000 0 -0.42 18 18
VEGFA 0 0.075 -10000 0 -0.29 31 31
BLK -0.005 0.092 -10000 0 -0.33 30 30
HCK 0.002 0.095 -10000 0 -0.32 41 41
FGF2 -0.064 0.16 -10000 0 -0.34 122 122
FGFR1 -0.013 0.11 -10000 0 -0.35 44 44
VEGFR1 homodimer 0.004 0.08 -10000 0 -0.45 15 15
TGFBR2 0.013 0.049 -10000 0 -0.43 6 6
cell death -0.025 0.13 -10000 0 -0.38 57 57
ATIII/GPC1 0.002 0.088 -10000 0 -0.38 23 23
PLA2G2A/GPC1 -0.041 0.12 -10000 0 -0.39 41 41
LCK -0.039 0.13 -10000 0 -0.32 82 82
neuron differentiation 0.002 0.089 -10000 0 -0.38 23 23
PrPc/Cu2+ 0.005 0.053 -10000 0 -0.38 9 9
APP -0.029 0.14 -10000 0 -0.43 56 56
TGFBR2 (dimer) 0.013 0.049 -10000 0 -0.43 6 6
Signaling mediated by p38-gamma and p38-delta

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K 0.018 0.062 -9999 0 -0.31 17 17
SNTA1 0.011 0.058 -9999 0 -0.48 7 7
response to hypoxia 0 0 -9999 0 -10000 0 0
STMN1 0.004 0.086 -9999 0 -0.32 31 31
MAPK12 -0.004 0.092 -9999 0 -0.28 46 46
CCND1 -0.07 0.17 -9999 0 -0.42 91 91
p38 gamma/SNTA1 0.002 0.093 -9999 0 -0.26 51 51
MAP2K3 0.014 0.037 -9999 0 -0.29 7 7
PKN1 0.013 0.045 -9999 0 -0.39 6 6
G2/M transition checkpoint -0.004 0.091 -9999 0 -0.28 46 46
MAP2K6 -0.005 0.091 -9999 0 -0.3 43 43
MAPT -0.054 0.15 -9999 0 -0.32 120 120
MAPK13 0.011 0.071 -9999 0 -0.38 16 16
hyperosmotic response 0 0 -9999 0 -10000 0 0
ZAK 0.003 0.072 -9999 0 -0.33 23 23
Class IB PI3K non-lipid kinase events

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process 0.004 0.088 0.33 33 -10000 0 33
PI3K Class IB/PDE3B -0.004 0.088 -10000 0 -0.33 33 33
PDE3B -0.004 0.088 -10000 0 -0.33 33 33
Regulation of nuclear SMAD2/3 signaling

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.019 0.049 -10000 0 -0.51 4 4
HSPA8 0.001 0.09 -10000 0 -0.52 15 15
SMAD3/SMAD4/ER alpha -0.091 0.2 0.23 5 -0.36 162 167
AKT1 0.01 0.056 -10000 0 -0.37 9 9
GSC -0.2 0.49 -10000 0 -1.4 77 77
NKX2-5 -0.018 0.093 -10000 0 -0.26 67 67
muscle cell differentiation 0.066 0.16 0.47 46 -10000 0 46
SMAD2-3/SMAD4/SP1 -0.006 0.18 -10000 0 -0.43 57 57
SMAD4 -0.015 0.1 -10000 0 -0.32 33 33
CBFB 0.015 0.037 -10000 0 -0.39 4 4
SAP18 0.017 0.002 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.014 0.075 -10000 0 -0.29 8 8
SMAD3/SMAD4/VDR 0.027 0.12 -10000 0 -0.36 27 27
MYC -0.024 0.14 -10000 0 -0.44 49 49
CDKN2B -0.047 0.3 -10000 0 -1.3 25 25
AP1 -0.068 0.23 -10000 0 -0.54 76 76
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.037 0.066 -10000 0 -0.28 2 2
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 0.004 0.12 -10000 0 -0.34 36 36
SP3 0.014 0.02 -10000 0 -10000 0 0
CREB1 0.017 0.023 -10000 0 -0.52 1 1
FOXH1 -0.001 0.042 -10000 0 -10000 0 0
SMAD3/SMAD4/GR -0.004 0.13 -10000 0 -0.36 44 44
GATA3 -0.099 0.22 -10000 0 -0.5 124 124
SKI/SIN3/HDAC complex/NCoR1 0.042 0.037 -10000 0 -10000 0 0
MEF2C/TIF2 -0.028 0.17 -10000 0 -0.51 40 40
endothelial cell migration 0.018 0.24 1.3 16 -10000 0 16
MAX 0.018 0.009 -10000 0 -10000 0 0
RBBP7 0.01 0.051 -10000 0 -0.3 13 13
RBBP4 0.016 0.026 -10000 0 -0.39 2 2
RUNX2 0.013 0.049 -10000 0 -0.43 6 6
RUNX3 -0.062 0.18 -10000 0 -0.4 101 101
RUNX1 -0.027 0.14 -10000 0 -0.42 54 54
CTBP1 0.017 0.017 -10000 0 -0.25 2 2
NR3C1 -0.001 0.099 -10000 0 -0.51 19 19
VDR -0.003 0.1 -10000 0 -0.51 21 21
CDKN1A -0.03 0.27 -10000 0 -1.3 18 18
KAT2B 0.001 0.006 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 -0.016 0.13 -10000 0 -0.32 48 48
DCP1A 0.017 0.023 -10000 0 -0.52 1 1
SKI 0.016 0.017 -10000 0 -0.25 2 2
SERPINE1 -0.019 0.24 -10000 0 -1.3 16 16
SMAD3/SMAD4/ATF2 0.006 0.11 -10000 0 -0.33 30 30
SMAD3/SMAD4/ATF3 -0.017 0.14 -10000 0 -0.35 55 55
SAP30 0.012 0.053 -10000 0 -0.48 6 6
Cbp/p300/PIAS3 0.047 0.053 -10000 0 -0.29 6 6
JUN -0.07 0.22 -10000 0 -0.54 75 75
SMAD3/SMAD4/IRF7 0.002 0.13 -10000 0 -0.37 36 36
TFE3 0.018 0.026 -10000 0 -10000 0 0
COL1A2 -0.1 0.37 -10000 0 -1 72 72
mesenchymal cell differentiation -0.003 0.11 0.35 33 -10000 0 33
DLX1 -0.009 0.081 -10000 0 -0.25 53 53
TCF3 0.013 0.044 -10000 0 -0.32 8 8
FOS -0.11 0.2 -10000 0 -0.38 171 171
SMAD3/SMAD4/Max 0.008 0.11 -10000 0 -0.33 30 30
Cbp/p300/SNIP1 0.035 0.046 -10000 0 -0.3 9 9
ZBTB17 0.019 0.012 -10000 0 -10000 0 0
LAMC1 0.003 0.15 -10000 0 -0.53 30 30
TGIF2/HDAC complex/SMAD3/SMAD4 0.001 0.12 -10000 0 -0.35 36 36
IRF7 0.007 0.079 -10000 0 -0.49 12 12
ESR1 -0.15 0.24 -10000 0 -0.46 182 182
HNF4A 0.016 0.033 -10000 0 -0.52 2 2
MEF2C -0.035 0.18 -10000 0 -0.54 40 40
SMAD2-3/SMAD4 -0.008 0.12 -10000 0 -0.34 40 40
Cbp/p300/Src-1 0.036 0.055 -10000 0 -0.28 12 12
IGHV3OR16-13 -0.017 0.039 -10000 0 -0.52 1 1
TGIF2/HDAC complex 0.009 0.066 -10000 0 -0.42 11 11
CREBBP 0.019 0.034 -10000 0 -0.51 2 2
SKIL 0.005 0.07 -10000 0 -0.34 19 19
HDAC1 0.016 0.023 -10000 0 -0.52 1 1
HDAC2 0.008 0.053 -10000 0 -0.29 15 15
SNIP1 0.014 0.041 -10000 0 -0.52 3 3
GCN5L2 0.018 0.044 -10000 0 -0.46 4 4
SMAD3/SMAD4/TFE3 0.014 0.12 -10000 0 -0.33 44 44
MSG1/HSC70 -0.019 0.097 -10000 0 -0.41 16 16
SMAD2 -0.002 0.051 -10000 0 -0.51 1 1
SMAD3 -0.004 0.1 -10000 0 -0.47 17 17
SMAD3/E2F4-5/DP1/p107/SMAD4 0.008 0.097 -10000 0 -0.29 28 28
SMAD2/SMAD2/SMAD4 -0.007 0.055 -10000 0 -0.3 10 10
NCOR1 0.015 0.033 -10000 0 -0.52 2 2
NCOA2 0.009 0.063 -10000 0 -0.4 11 11
NCOA1 0.012 0.057 -10000 0 -0.52 6 6
MYOD/E2A -0.001 0.097 -10000 0 -0.37 31 31
SMAD2-3/SMAD4/SP1/MIZ-1 0.007 0.17 -10000 0 -0.43 47 47
IFNB1 0.005 0.13 -10000 0 -0.43 27 27
SMAD3/SMAD4/MEF2C -0.027 0.2 -10000 0 -0.55 47 47
CITED1 -0.029 0.1 -10000 0 -0.26 89 89
SMAD2-3/SMAD4/ARC105 0.009 0.12 -10000 0 -0.34 25 25
RBL1 0.01 0.048 -10000 0 -0.27 14 14
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB 0.001 0.15 -10000 0 -0.48 35 35
RUNX1-3/PEBPB2 -0.042 0.14 -10000 0 -0.34 86 86
SMAD7 -0.042 0.23 -10000 0 -0.6 49 49
MYC/MIZ-1 -0.003 0.1 -10000 0 -0.36 34 34
SMAD3/SMAD4 0.046 0.14 0.3 39 -0.4 15 54
IL10 -0.046 0.18 -10000 0 -0.39 82 82
PIASy/HDAC complex 0.009 0.051 -10000 0 -0.44 6 6
PIAS3 0.019 0.005 -10000 0 -10000 0 0
CDK2 0.015 0.048 -10000 0 -0.3 10 10
IL5 -0.047 0.18 -10000 0 -0.38 80 80
CDK4 0.019 0.029 -10000 0 -0.25 5 5
PIAS4 0.009 0.051 -10000 0 -0.44 6 6
ATF3 -0.02 0.13 -10000 0 -0.41 47 47
SMAD3/SMAD4/SP1 -0.01 0.18 -10000 0 -0.42 61 61
FOXG1 -0.007 0.083 -10000 0 -0.27 45 45
FOXO3 0.015 0.061 -10000 0 -0.4 8 8
FOXO1 0.007 0.081 -10000 0 -0.37 20 20
FOXO4 0.019 0.047 -10000 0 -0.37 5 5
heart looping -0.034 0.17 -10000 0 -0.53 40 40
CEBPB 0.004 0.073 -10000 0 -0.34 20 20
SMAD3/SMAD4/DLX1 -0.01 0.12 -10000 0 -0.33 38 38
MYOD1 -0.015 0.13 -10000 0 -0.47 36 36
SMAD3/SMAD4/HNF4 0.005 0.11 -10000 0 -0.32 33 33
SMAD3/SMAD4/GATA3 -0.062 0.2 -10000 0 -0.38 127 127
SnoN/SIN3/HDAC complex/NCoR1 0.005 0.07 -10000 0 -0.34 19 19
SMAD3/SMAD4/RUNX1-3/PEBPB2 -0.036 0.17 -10000 0 -0.34 100 100
SMAD3/SMAD4/SP1-3 -0.001 0.19 -10000 0 -0.47 53 53
MED15 0.018 0 -10000 0 -10000 0 0
SP1 -0.002 0.069 -10000 0 -0.23 18 18
SIN3B 0.017 0.012 -10000 0 -0.25 1 1
SIN3A 0.017 0.002 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 -0.02 0.15 -10000 0 -0.38 45 45
ITGB5 -0.032 0.23 -10000 0 -0.65 56 56
TGIF/SIN3/HDAC complex/CtBP 0.041 0.042 -10000 0 -10000 0 0
SMAD3/SMAD4/AR -0.061 0.19 -10000 0 -0.39 117 117
AR -0.088 0.21 -10000 0 -0.52 104 104
negative regulation of cell growth -0.002 0.12 -10000 0 -0.36 33 33
SMAD3/SMAD4/MYOD -0.016 0.13 -10000 0 -0.32 59 59
E2F5 -0.014 0.12 -10000 0 -0.39 41 41
E2F4 0.017 0.017 -10000 0 -0.25 2 2
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.01 0.11 -10000 0 -0.32 18 18
SMAD2-3/SMAD4/FOXO1-3a-4 0.005 0.13 -10000 0 -0.36 41 41
TFDP1 0.011 0.042 -10000 0 -0.25 13 13
SMAD3/SMAD4/AP1 -0.064 0.24 -10000 0 -0.55 75 75
SMAD3/SMAD4/RUNX2 0.003 0.12 -10000 0 -0.35 33 33
TGIF2 0.009 0.066 -10000 0 -0.42 11 11
TGIF1 0.008 0.073 -10000 0 -0.52 10 10
ATF2 0.018 0 -10000 0 -10000 0 0
TRAIL signaling pathway

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 -0.042 0.16 -10000 0 -0.46 67 67
positive regulation of NF-kappaB transcription factor activity -0.019 0.12 -10000 0 -0.37 52 52
MAP2K4 -0.013 0.12 -10000 0 -0.38 28 28
IKBKB 0.012 0.047 -10000 0 -0.31 10 10
TNFRSF10B 0.005 0.079 -10000 0 -0.46 14 14
TNFRSF10A -0.004 0.1 -10000 0 -0.47 24 24
SMPD1 -0.008 0.086 -10000 0 -0.23 58 58
IKBKG 0.018 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D 0.015 0.031 -10000 0 -0.32 4 4
TRAIL/TRAILR2 -0.026 0.14 -10000 0 -0.4 57 57
TRAIL/TRAILR3 -0.032 0.13 -10000 0 -0.37 54 54
TRAIL/TRAILR1 -0.032 0.14 -10000 0 -0.4 64 64
TRAIL/TRAILR4 -0.019 0.12 -10000 0 -0.37 52 52
TRAIL/TRAILR1/DAP3/GTP -0.013 0.12 -10000 0 -0.3 65 65
IKK complex -0.028 0.082 -10000 0 -0.42 15 15
RIPK1 0.017 0.023 -10000 0 -0.52 1 1
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP 0.012 0.019 -10000 0 -0.27 2 2
MAPK3 -0.019 0.12 -10000 0 -0.37 52 52
MAP3K1 -0.01 0.12 -10000 0 -0.38 26 26
TRAILR4 (trimer) 0.015 0.031 -10000 0 -0.32 4 4
TRADD 0.016 0.026 -10000 0 -0.39 2 2
TRAILR1 (trimer) -0.004 0.1 -10000 0 -0.46 24 24
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 -0.004 0.11 -10000 0 -0.43 13 13
CFLAR 0.009 0.065 -10000 0 -0.44 10 10
MAPK1 -0.02 0.12 -10000 0 -0.37 53 53
TRAIL/TRAILR1/FADD/TRADD/RIP -0.002 0.12 -10000 0 -0.29 64 64
mol:ceramide -0.008 0.086 -10000 0 -0.23 58 58
FADD 0 0.067 -10000 0 -0.25 35 35
MAPK8 -0.007 0.12 -10000 0 -0.39 23 23
TRAF2 0.014 0.042 -10000 0 -0.45 4 4
TRAILR3 (trimer) -0.004 0.075 -10000 0 -0.26 41 41
CHUK 0.005 0.081 -10000 0 -0.5 13 13
TRAIL/TRAILR1/FADD -0.025 0.13 -10000 0 -0.34 65 65
DAP3 0.016 0.026 -10000 0 -0.39 2 2
CASP10 -0.05 0.12 0.26 1 -0.36 54 55
JNK cascade -0.019 0.12 -10000 0 -0.37 52 52
TRAIL (trimer) -0.042 0.16 -10000 0 -0.46 67 67
TNFRSF10C -0.004 0.075 -10000 0 -0.26 41 41
TRAIL/TRAILR1/DAP3/GTP/FADD -0.011 0.12 -10000 0 -0.29 65 65
TRAIL/TRAILR2/FADD -0.019 0.13 -10000 0 -0.34 58 58
cell death -0.008 0.086 -10000 0 -0.23 58 58
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0 0.11 -10000 0 -0.27 59 59
TRAILR2 (trimer) 0.005 0.079 -10000 0 -0.46 14 14
CASP8 0.01 0.042 -10000 0 -10000 0 0
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.003 0.12 -10000 0 -0.29 56 56
E-cadherin signaling in the nascent adherens junction

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.037 0.17 -9999 0 -0.45 74 74
KLHL20 -0.015 0.099 -9999 0 -0.25 25 25
CYFIP2 -0.042 0.16 -9999 0 -0.47 65 65
Rac1/GDP 0.006 0.11 -9999 0 -0.25 74 74
ENAH -0.036 0.18 -9999 0 -0.45 76 76
AP1M1 0.017 0.023 -9999 0 -0.52 1 1
RAP1B 0.013 0.044 -9999 0 -0.32 8 8
RAP1A 0.012 0.057 -9999 0 -0.52 6 6
CTNNB1 0.001 0.09 -9999 0 -0.45 19 19
CDC42/GTP -0.032 0.069 -9999 0 -0.3 10 10
ABI1/Sra1/Nap1 -0.042 0.054 -9999 0 -0.17 36 36
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.005 0.12 -9999 0 -0.28 79 79
RAPGEF1 -0.015 0.15 -9999 0 -0.38 74 74
CTNND1 0.016 0.029 -9999 0 -0.34 3 3
regulation of calcium-dependent cell-cell adhesion -0.039 0.17 -9999 0 -0.46 74 74
CRK -0.024 0.16 -9999 0 -0.41 74 74
E-cadherin/gamma catenin/alpha catenin -0.01 0.12 -9999 0 -0.31 65 65
alphaE/beta7 Integrin 0.023 0.038 -9999 0 -0.37 5 5
IQGAP1 0.018 0 -9999 0 -10000 0 0
NCKAP1 0.015 0.031 -9999 0 -0.32 4 4
Rap1/GTP/I-afadin 0.014 0.073 -9999 0 -0.28 28 28
DLG1 -0.031 0.17 -9999 0 -0.44 74 74
ChemicalAbstracts:7440-70-2 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.028 0.055 -9999 0 -0.22 15 15
MLLT4 -0.006 0.11 -9999 0 -0.46 26 26
ARF6/GTP/NME1/Tiam1 0.023 0.052 -9999 0 -0.3 10 10
PI3K -0.036 0.07 -9999 0 -0.29 13 13
ARF6 0.016 0.033 -9999 0 -0.52 2 2
mol:Ca2+ 0 0 -9999 0 -10000 0 0
E-cadherin/gamma catenin -0.027 0.13 -9999 0 -0.37 64 64
TIAM1 0.006 0.073 -9999 0 -0.44 13 13
E-cadherin(dimer)/Ca2+ -0.005 0.11 -9999 0 -0.26 76 76
AKT1 -0.022 0.043 -9999 0 -0.17 14 14
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
CDH1 -0.049 0.17 -9999 0 -0.48 70 70
RhoA/GDP 0.003 0.12 -9999 0 -0.32 27 27
actin cytoskeleton organization -0.009 0.075 -9999 0 -0.18 25 25
CDC42/GDP 0.008 0.11 -9999 0 -0.29 23 23
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.007 0.09 -9999 0 -0.24 66 66
ITGB7 0.018 0 -9999 0 -10000 0 0
RAC1 0.018 0 -9999 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin -0.005 0.11 -9999 0 -0.28 76 76
E-cadherin/Ca2+/beta catenin/alpha catenin -0.014 0.1 -9999 0 -0.27 75 75
mol:GDP -0.004 0.13 -9999 0 -0.3 75 75
CDC42/GTP/IQGAP1 0.024 0 -9999 0 -10000 0 0
JUP 0.011 0.056 -9999 0 -0.42 8 8
p120 catenin/RhoA/GDP 0.002 0.12 -9999 0 -0.34 20 20
RAC1/GTP/IQGAP1 0.024 0 -9999 0 -10000 0 0
PIP5K1C/AP1M1 0.023 0.035 -9999 0 -0.37 4 4
RHOA 0.005 0.08 -9999 0 -0.52 12 12
CDC42 0.018 0 -9999 0 -10000 0 0
CTNNA1 0.017 0.023 -9999 0 -0.52 1 1
positive regulation of S phase of mitotic cell cycle -0.027 0.094 -9999 0 -0.2 97 97
NME1 0.012 0.039 -9999 0 -0.25 11 11
clathrin coat assembly 0 0 -9999 0 -10000 0 0
TJP1 -0.033 0.17 -9999 0 -0.44 75 75
regulation of cell-cell adhesion -0.029 0.061 -9999 0 -0.26 10 10
WASF2 -0.021 0.031 -9999 0 -0.15 2 2
Rap1/GTP -0.038 0.08 -9999 0 -0.34 10 10
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.009 0.1 -9999 0 -0.25 70 70
CCND1 -0.035 0.12 -9999 0 -0.26 95 95
VAV2 -0.022 0.16 -9999 0 -0.4 74 74
RAP1/GDP 0.005 0.11 -9999 0 -0.36 9 9
adherens junction assembly -0.031 0.17 -9999 0 -0.43 75 75
homophilic cell adhesion 0 0 -9999 0 -10000 0 0
ABI1 0.016 0.02 -9999 0 -0.25 3 3
PIP5K1C 0.014 0.042 -9999 0 -0.45 4 4
regulation of heterotypic cell-cell adhesion 0.006 0.11 -9999 0 -0.33 7 7
E-cadherin/beta catenin -0.045 0.11 -9999 0 -0.34 64 64
mol:GTP 0 0 -9999 0 -10000 0 0
SRC -0.033 0.17 -9999 0 -0.44 75 75
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
Rac1/GTP -0.078 0.12 -9999 0 -0.42 27 27
E-cadherin/beta catenin/alpha catenin -0.017 0.12 -9999 0 -0.31 75 75
ITGAE 0.013 0.052 -9999 0 -0.52 5 5
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.18 -9999 0 -0.47 74 74
Presenilin action in Notch and Wnt signaling

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) 0.025 0.076 -10000 0 -0.64 6 6
HDAC1 0.022 0.03 -10000 0 -0.53 1 1
AES 0.019 0.006 -10000 0 -10000 0 0
FBXW11 0.015 0.035 -10000 0 -0.43 3 3
DTX1 0.012 0.049 -10000 0 -0.34 9 9
LRP6/FZD1 0.009 0.076 -10000 0 -0.36 19 19
TLE1 -0.031 0.15 -10000 0 -0.45 56 56
AP1 -0.05 0.13 -10000 0 -0.3 82 82
NCSTN 0.017 0.023 -10000 0 -0.52 1 1
ADAM10 0.013 0.045 -10000 0 -0.39 6 6
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.041 0.13 -10000 0 -0.42 8 8
NICD/RBPSUH 0.027 0.076 -10000 0 -0.63 6 6
WIF1 -0.024 0.098 -10000 0 -0.25 81 81
NOTCH1 -0.003 0.077 -10000 0 -0.67 6 6
PSENEN 0.017 0.012 -10000 0 -0.25 1 1
KREMEN2 -0.19 0.23 -10000 0 -0.41 257 257
DKK1 -0.12 0.19 -10000 0 -0.34 199 199
beta catenin/beta TrCP1 0.004 0.084 0.24 4 -0.35 17 21
APH1B 0.001 0.093 -10000 0 -0.51 17 17
APH1A 0.003 0.067 -10000 0 -0.29 25 25
AXIN1 0.006 0.04 0.24 8 -0.23 3 11
CtBP/CBP/TCF1/TLE1/AES 0.036 0.1 0.29 5 -0.26 1 6
PSEN1 0.013 0.052 -10000 0 -0.52 5 5
FOS -0.11 0.2 -10000 0 -0.37 171 171
JUN -0.034 0.15 -10000 0 -0.46 57 57
MAP3K7 0.019 0.022 -10000 0 -0.26 3 3
CTNNB1 -0.005 0.084 0.23 6 -0.38 15 21
MAPK3 0.016 0.026 -10000 0 -0.39 2 2
DKK2/LRP6/Kremen 2 -0.12 0.16 -10000 0 -0.33 186 186
HNF1A 0.017 0.026 -10000 0 -0.24 5 5
CTBP1 0.018 0.018 -10000 0 -0.26 2 2
MYC -0.086 0.34 -10000 0 -1.4 34 34
NKD1 0.01 0.059 -10000 0 -0.38 11 11
FZD1 0.003 0.082 -10000 0 -0.43 17 17
NOTCH1 precursor/Deltex homolog 1 0.024 0.085 -10000 0 -0.69 6 6
apoptosis -0.05 0.12 -10000 0 -0.3 82 82
Delta 1/NOTCHprecursor 0.027 0.076 -10000 0 -0.63 6 6
DLL1 0.017 0.012 -10000 0 -0.25 1 1
PPARD 0.004 0.045 -10000 0 -10000 0 0
Gamma Secretase 0.031 0.069 -10000 0 -0.25 25 25
APC 0.002 0.055 0.24 7 -0.35 7 14
DVL1 0.022 0.038 -10000 0 -0.38 3 3
CSNK2A1 0.016 0.023 -10000 0 -0.52 1 1
MAP3K7IP1 0.02 0.008 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 -0.17 0.17 -10000 0 -0.34 249 249
LRP6 0.008 0.065 -10000 0 -0.38 13 13
CSNK1A1 0.016 0.024 -10000 0 -0.52 1 1
NLK 0.032 0.03 -10000 0 -0.26 1 1
CCND1 -0.22 0.51 -10000 0 -1.4 87 87
WNT1 0.017 0.023 -10000 0 -0.52 1 1
Axin1/APC/beta catenin 0.017 0.074 0.28 4 -0.35 6 10
DKK2 -0.026 0.14 -10000 0 -0.42 52 52
NOTCH1 precursor/DVL1 0.036 0.077 -10000 0 -0.54 7 7
GSK3B 0.018 0.001 -10000 0 -10000 0 0
FRAT1 0.01 0.068 -10000 0 -0.47 10 10
NOTCH/Deltex homolog 1 0.022 0.085 -10000 0 -0.7 6 6
PPP2R5D 0.013 0.036 0.27 5 -10000 0 5
MAPK1 0.016 0.033 -10000 0 -0.52 2 2
WNT1/LRP6/FZD1 0.009 0.079 -10000 0 -0.27 23 23
RBPJ 0.018 0 -10000 0 -10000 0 0
CREBBP 0.013 0.035 -10000 0 -0.52 2 2
Syndecan-3-mediated signaling events

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.003 0.068 -9999 0 -0.28 26 26
Syndecan-3/Src/Cortactin -0.046 0.16 -9999 0 -0.52 35 35
Syndecan-3/Neurocan -0.007 0.13 -9999 0 -0.57 24 24
POMC 0.001 0.072 -9999 0 -0.28 30 30
EGFR -0.079 0.18 -9999 0 -0.35 139 139
Syndecan-3/EGFR -0.049 0.16 -9999 0 -0.39 68 68
AGRP 0.016 0.029 -9999 0 -0.34 3 3
NCSTN 0.017 0.023 -9999 0 -0.52 1 1
PSENEN 0.017 0.012 -9999 0 -0.25 1 1
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.001 0.093 -9999 0 -0.51 17 17
APH1A 0.003 0.067 -9999 0 -0.29 25 25
NCAN 0.007 0.053 -9999 0 -0.25 21 21
long-term memory -0.003 0.13 -9999 0 -0.55 25 25
Syndecan-3/IL8 -0.045 0.16 -9999 0 -0.42 58 58
PSEN1 0.013 0.052 -9999 0 -0.52 5 5
Src/Cortactin 0.014 0.054 -9999 0 -0.37 5 5
FYN 0.008 0.067 -9999 0 -0.41 12 12
limb bud formation -0.031 0.12 -9999 0 -0.59 24 24
MC4R 0.014 0.039 -9999 0 -0.36 5 5
SRC 0.015 0.035 -9999 0 -0.43 3 3
PTN -0.099 0.19 -9999 0 -0.37 158 158
FGFR/FGF/Syndecan-3 -0.032 0.12 -9999 0 -0.6 24 24
neuron projection morphogenesis -0.045 0.16 -9999 0 -0.47 40 40
Syndecan-3/AgRP -0.003 0.13 -9999 0 -0.56 25 25
Syndecan-3/AgRP/MC4R 0.006 0.13 -9999 0 -0.56 24 24
Fyn/Cortactin 0.009 0.068 -9999 0 -0.38 10 10
SDC3 -0.032 0.13 -9999 0 -0.61 24 24
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.044 0.15 -9999 0 -0.41 58 58
IL8 -0.072 0.17 -9999 0 -0.34 135 135
Syndecan-3/Fyn/Cortactin -0.003 0.13 -9999 0 -0.57 25 25
Syndecan-3/CASK -0.03 0.12 -9999 0 -0.58 24 24
alpha-MSH/MC4R 0.012 0.057 -9999 0 -0.37 5 5
Gamma Secretase 0.033 0.069 -9999 0 -0.25 25 25
Nectin adhesion pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.01 0.066 -9999 0 -0.52 8 8
alphaV beta3 Integrin 0.001 0.094 -9999 0 -0.4 22 22
PTK2 -0.001 0.15 -9999 0 -0.46 42 42
positive regulation of JNK cascade -0.028 0.086 -9999 0 -0.31 43 43
CDC42/GDP 0.021 0.13 -9999 0 -0.42 41 41
Rac1/GDP 0.023 0.13 -9999 0 -0.41 41 41
RAP1B 0.013 0.044 -9999 0 -0.32 8 8
RAP1A 0.012 0.057 -9999 0 -0.52 6 6
CTNNB1 0.001 0.09 -9999 0 -0.45 19 19
CDC42/GTP -0.033 0.11 -9999 0 -0.38 43 43
nectin-3/I-afadin -0.016 0.12 -9999 0 -0.41 41 41
RAPGEF1 0.009 0.15 -9999 0 -0.47 41 41
mol:GTP 0 0 -9999 0 -10000 0 0
CRK -0.001 0.17 -9999 0 -0.54 41 41
PDGFB-D/PDGFRB 0.01 0.066 -9999 0 -0.52 8 8
TLN1 0.004 0.099 -9999 0 -0.4 20 20
Rap1/GTP -0.031 0.093 -9999 0 -0.33 42 42
IQGAP1 0.018 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0.015 0.073 -9999 0 -0.28 28 28
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.016 0.12 -9999 0 -0.41 41 41
PVR 0.008 0.059 -9999 0 -0.33 14 14
Necl-5(dimer) 0.008 0.059 -9999 0 -0.33 14 14
mol:GDP 0.011 0.16 -9999 0 -0.51 41 41
MLLT4 -0.006 0.11 -9999 0 -0.46 26 26
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
PI3K 0.001 0.13 -9999 0 -0.32 59 59
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.007 0.082 -9999 0 -0.38 21 21
positive regulation of lamellipodium assembly -0.028 0.088 -9999 0 -0.32 41 41
PVRL1 0.014 0.035 -9999 0 -0.3 6 6
PVRL3 -0.019 0.12 -9999 0 -0.4 46 46
PVRL2 0.002 0.089 -9999 0 -0.52 15 15
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
CDH1 -0.049 0.17 -9999 0 -0.48 70 70
CLDN1 -0.11 0.21 -9999 0 -0.4 165 165
JAM-A/CLDN1 -0.065 0.16 -9999 0 -0.32 128 128
SRC -0.01 0.18 -9999 0 -0.61 41 41
ITGB3 0.002 0.075 -9999 0 -0.32 25 25
nectin-1(dimer)/I-afadin/I-afadin 0.007 0.082 -9999 0 -0.38 21 21
FARP2 0.006 0.16 -9999 0 -0.51 43 43
RAC1 0.018 0 -9999 0 -10000 0 0
CTNNA1 0.017 0.023 -9999 0 -0.52 1 1
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) -0.006 0.11 -9999 0 -0.35 44 44
nectin-1/I-afadin 0.007 0.082 -9999 0 -0.38 21 21
nectin-2/I-afadin -0.002 0.1 -9999 0 -0.39 33 33
RAC1/GTP/IQGAP1/filamentous actin 0.024 0 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.002 0.11 -9999 0 -0.34 43 43
CDC42/GTP/IQGAP1/filamentous actin 0.024 0 -9999 0 -10000 0 0
F11R 0.011 0.055 -9999 0 -0.36 10 10
positive regulation of filopodium formation -0.028 0.086 -9999 0 -0.31 43 43
alphaV/beta3 Integrin/Talin 0.006 0.13 -9999 0 -0.48 20 20
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.1 -9999 0 -0.39 33 33
nectin-2(dimer)/I-afadin/I-afadin -0.002 0.1 -9999 0 -0.39 33 33
PIP5K1C -0.004 0.1 -9999 0 -0.42 21 21
VAV2 0.006 0.16 -9999 0 -0.52 41 41
RAP1/GDP 0.019 0.13 -9999 0 -0.38 42 42
ITGAV -0.002 0.1 -9999 0 -0.48 21 21
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin -0.01 0.12 -9999 0 -0.35 53 53
nectin-3(dimer)/I-afadin/I-afadin -0.016 0.12 -9999 0 -0.41 41 41
Rac1/GTP -0.032 0.11 -9999 0 -0.4 41 41
PTPRM -0.011 0.11 -9999 0 -0.31 47 47
E-cadherin/beta catenin/alpha catenin -0.012 0.13 -9999 0 -0.46 11 11
adherens junction assembly 0 0 -9999 0 -10000 0 0
CDC42 0.018 0 -9999 0 -10000 0 0
Reelin signaling pathway

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.023 0.028 -9999 0 -0.37 1 1
VLDLR -0.061 0.17 -9999 0 -0.4 100 100
CRKL 0.014 0.047 -9999 0 -0.52 4 4
LRPAP1 0.016 0.026 -9999 0 -0.39 2 2
FYN 0.008 0.067 -9999 0 -0.41 12 12
ITGA3 -0.003 0.096 -9999 0 -0.41 25 25
RELN/VLDLR/Fyn -0.023 0.12 -9999 0 -0.32 64 64
MAPK8IP1/MKK7/MAP3K11/JNK1 0.038 0.061 -9999 0 -0.36 2 2
AKT1 -0.011 0.11 -9999 0 -0.42 15 15
MAP2K7 0.017 0.023 -9999 0 -0.52 1 1
RAPGEF1 0.018 0 -9999 0 -10000 0 0
DAB1 0.018 0 -9999 0 -10000 0 0
RELN/LRP8/DAB1 -0.011 0.094 -9999 0 -0.28 42 42
LRPAP1/LRP8 -0.027 0.11 -9999 0 -0.37 37 37
RELN/LRP8/DAB1/Fyn -0.006 0.096 -9999 0 -0.26 48 48
DAB1/alpha3/beta1 Integrin -0.067 0.11 -9999 0 -0.37 26 26
long-term memory -0.002 0.1 -9999 0 -0.39 6 6
DAB1/LIS1 -0.028 0.12 -9999 0 -0.25 93 93
DAB1/CRLK/C3G -0.059 0.097 -9999 0 -0.37 16 16
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
DAB1/NCK2 -0.029 0.12 -9999 0 -0.25 94 94
ARHGEF2 0.004 0.079 -9999 0 -0.41 17 17
mol:Src family inhibitors PP1 and PP2 0 0 -9999 0 -10000 0 0
GRIN2A 0.017 0.012 -9999 0 -0.25 1 1
CDK5R1 0.014 0.031 -9999 0 -0.25 7 7
RELN 0.01 0.059 -9999 0 -0.38 11 11
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
RELN/LRP8/Fyn -0.02 0.11 -9999 0 -0.32 48 48
GRIN2A/RELN/LRP8/DAB1/Fyn 0.004 0.097 -9999 0 -0.26 47 47
MAPK8 0.015 0.04 -9999 0 -0.52 3 3
RELN/VLDLR/DAB1 -0.014 0.1 -9999 0 -0.28 59 59
ITGB1 0.014 0.044 -9999 0 -0.41 5 5
MAP1B -0.058 0.15 -9999 0 -0.3 111 111
RELN/LRP8 -0.015 0.1 -9999 0 -0.31 43 43
GRIN2B/RELN/LRP8/DAB1/Fyn -0.009 0.11 -9999 0 -0.26 65 65
PI3K 0.005 0.082 -9999 0 -0.37 21 21
mol:PP2 0 0 -9999 0 -10000 0 0
alpha3/beta1 Integrin 0.009 0.078 -9999 0 -0.39 17 17
RAP1A -0.019 0.12 -9999 0 -0.36 17 17
PAFAH1B1 0.017 0.023 -9999 0 -0.52 1 1
MAPK8IP1 0.011 0.048 -9999 0 -0.3 11 11
CRLK/C3G 0.023 0.034 -9999 0 -0.37 4 4
GRIN2B -0.007 0.1 -9999 0 -0.44 28 28
NCK2 0.015 0.026 -9999 0 -0.25 5 5
neuron differentiation 0.011 0.079 -9999 0 -0.33 4 4
neuron adhesion -0.016 0.12 -9999 0 -0.33 28 28
LRP8 -0.057 0.16 -9999 0 -0.34 110 110
GSK3B -0.004 0.1 -9999 0 -0.4 14 14
RELN/VLDLR/DAB1/Fyn -0.009 0.11 -9999 0 -0.27 64 64
MAP3K11 0.015 0.035 -9999 0 -0.43 3 3
RELN/VLDLR/DAB1/P13K -0.016 0.11 -9999 0 -0.26 74 74
CDK5 0.016 0.026 -9999 0 -0.39 2 2
MAPT -0.089 0.2 -9999 0 -0.48 107 107
neuron migration -0.013 0.12 -9999 0 -0.35 27 27
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 0.011 0.079 -9999 0 -0.34 4 4
RELN/VLDLR -0.045 0.14 -9999 0 -0.28 113 113
Visual signal transduction: Cones

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin 0.019 0.061 -9999 0 -0.27 21 21
RGS9BP -0.072 0.18 -9999 0 -0.41 111 111
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
mol:Na + -0.016 0.089 -9999 0 -0.33 24 24
mol:ADP 0.011 0.025 -9999 0 -0.31 3 3
GNAT2 -0.004 0.1 -9999 0 -0.49 23 23
RGS9-1/Gbeta5/R9AP -0.056 0.15 -9999 0 -0.34 96 96
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP -0.001 0.089 -9999 0 -0.33 33 33
GRK7 0.015 0.035 -9999 0 -0.43 3 3
CNGB3 -0.006 0.086 -9999 0 -0.3 39 39
Cone Metarhodopsin II/X-Arrestin 0.013 0.008 -9999 0 -0.17 1 1
mol:Ca2+ -0.009 0.083 -9999 0 -0.29 27 27
Cone PDE6 -0.043 0.14 -9999 0 -0.29 114 114
Cone Metarhodopsin II 0.01 0.019 -9999 0 -0.24 3 3
Na + (4 Units) -0.005 0.085 -9999 0 -0.29 27 27
GNAT2/GDP -0.049 0.14 -9999 0 -0.29 112 112
GNB5 0.005 0.081 -9999 0 -0.5 13 13
mol:GMP (4 units) 0.001 0.091 -9999 0 -0.31 37 37
Cone Transducin 0.02 0.065 -9999 0 -0.29 21 21
SLC24A2 0.014 0.044 -9999 0 -0.41 5 5
GNB3/GNGT2 0.025 0.026 -9999 0 -0.37 2 2
GNB3 0.017 0.012 -9999 0 -0.25 1 1
GNAT2/GTP -0.003 0.076 -9999 0 -0.35 23 23
CNGA3 -0.028 0.12 -9999 0 -0.31 73 73
ARR3 0.017 0.012 -9999 0 -0.25 1 1
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel -0.016 0.089 -9999 0 -0.33 24 24
mol:Pi -0.056 0.15 -9999 0 -0.34 96 96
Cone CNG Channel -0.014 0.11 -9999 0 -0.3 53 53
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + 0.014 0.044 -9999 0 -0.41 5 5
RGS9 -0.033 0.13 -9999 0 -0.31 81 81
PDE6C 0.008 0.065 -9999 0 -0.38 13 13
GNGT2 0.016 0.033 -9999 0 -0.52 2 2
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H -0.001 0.093 -9999 0 -0.44 21 21
Cellular roles of Anthrax toxin

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 -0.024 0.14 -10000 0 -0.46 46 46
ANTXR2 0.002 0.09 -10000 0 -0.5 16 16
negative regulation of myeloid dendritic cell antigen processing and presentation -0.007 0.021 -10000 0 -0.074 44 44
monocyte activation -0.022 0.12 -10000 0 -0.41 41 41
MAP2K2 0.007 0.06 -10000 0 -0.77 3 3
MAP2K1 0.005 0.021 -10000 0 -0.095 7 7
MAP2K7 0.005 0.024 -10000 0 -0.27 1 1
MAP2K6 -0.009 0.063 -10000 0 -0.21 37 37
CYAA -0.014 0.092 -10000 0 -0.3 44 44
MAP2K4 -0.006 0.056 -10000 0 -0.21 31 31
IL1B -0.03 0.095 -10000 0 -0.28 55 55
Channel -0.009 0.1 -10000 0 -0.32 44 44
NLRP1 0.002 0.036 -10000 0 -0.2 9 9
CALM1 0.018 0 -10000 0 -10000 0 0
negative regulation of phagocytosis 0.007 0.027 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.007 0.021 0.074 44 -10000 0 44
MAPK3 0.005 0.024 -10000 0 -0.19 2 2
MAPK1 0.004 0.027 -10000 0 -0.27 2 2
PGR -0.14 0.12 -10000 0 -0.27 215 215
PA/Cellular Receptors -0.011 0.11 -10000 0 -0.35 44 44
apoptosis -0.007 0.021 -10000 0 -0.074 44 44
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) -0.008 0.094 -10000 0 -0.3 44 44
macrophage activation 0.011 0.028 -10000 0 -0.25 3 3
TNF -0.004 0.094 -10000 0 -0.36 31 31
VCAM1 -0.022 0.12 -10000 0 -0.42 41 41
platelet activation 0.007 0.027 -10000 0 -10000 0 0
MAPKKK cascade -0.001 0.034 0.12 18 -10000 0 18
IL18 -0.031 0.11 -10000 0 -0.28 67 67
negative regulation of macrophage activation -0.007 0.021 -10000 0 -0.074 44 44
LEF -0.007 0.021 -10000 0 -0.074 44 44
CASP1 -0.006 0.042 -10000 0 -0.098 60 60
mol:cAMP 0.007 0.027 -10000 0 -10000 0 0
necrosis -0.007 0.021 -10000 0 -0.074 44 44
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) -0.008 0.095 -10000 0 -0.3 44 44
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
PDGFR-alpha signaling pathway

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.025 0.13 -9999 0 -0.5 37 37
PDGF/PDGFRA/CRKL -0.006 0.1 -9999 0 -0.37 36 36
positive regulation of JUN kinase activity 0.019 0.077 -9999 0 -0.26 34 34
CRKL 0.014 0.047 -9999 0 -0.52 4 4
PDGF/PDGFRA/Caveolin-3 -0.004 0.097 -9999 0 -0.37 33 33
AP1 -0.18 0.34 -9999 0 -0.91 84 84
mol:IP3 -0.015 0.1 -9999 0 -0.39 33 33
PLCG1 -0.015 0.1 -9999 0 -0.39 33 33
PDGF/PDGFRA/alphaV Integrin -0.017 0.12 -9999 0 -0.4 47 47
RAPGEF1 0.018 0 -9999 0 -10000 0 0
CRK 0.016 0.033 -9999 0 -0.52 2 2
mol:Ca2+ -0.015 0.1 -9999 0 -0.39 33 33
CAV3 0.016 0.029 -9999 0 -0.34 3 3
CAV1 -0.001 0.083 -9999 0 -0.33 29 29
SHC/Grb2/SOS1 0.02 0.077 -9999 0 -0.27 34 34
PDGF/PDGFRA/Shf -0.009 0.1 -9999 0 -0.34 40 40
FOS -0.17 0.34 -9999 0 -0.89 84 84
JUN -0.051 0.11 -9999 0 -0.38 52 52
oligodendrocyte development -0.017 0.12 -9999 0 -0.4 47 47
GRB2 0.016 0.024 -9999 0 -0.25 4 4
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
mol:DAG -0.015 0.1 -9999 0 -0.39 33 33
PDGF/PDGFRA -0.025 0.13 -9999 0 -0.5 37 37
actin cytoskeleton reorganization -0.01 0.11 -9999 0 -0.39 38 38
SRF 0.028 0.025 -9999 0 -0.35 1 1
SHC1 0.017 0.023 -9999 0 -0.52 1 1
PI3K -0.007 0.11 -9999 0 -0.34 49 49
PDGF/PDGFRA/Crk/C3G 0.01 0.085 -9999 0 -0.31 33 33
JAK1 -0.009 0.1 -9999 0 -0.38 37 37
ELK1/SRF 0.012 0.083 -9999 0 -0.28 36 36
SHB 0.008 0.067 -9999 0 -0.41 12 12
SHF 0.01 0.049 -9999 0 -0.27 15 15
CSNK2A1 0.025 0.029 -9999 0 -0.49 1 1
GO:0007205 -0.018 0.11 -9999 0 -0.42 33 33
SOS1 0.017 0.023 -9999 0 -0.52 1 1
Ras protein signal transduction 0.019 0.077 -9999 0 -0.26 34 34
PDGF/PDGFRA/SHB -0.01 0.11 -9999 0 -0.39 38 38
PDGF/PDGFRA/Caveolin-1 -0.016 0.12 -9999 0 -0.41 36 36
ITGAV -0.002 0.1 -9999 0 -0.48 21 21
ELK1 -0.018 0.1 -9999 0 -0.36 36 36
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
PDGF/PDGFRA/Crk -0.004 0.1 -9999 0 -0.38 33 33
JAK-STAT cascade -0.009 0.1 -9999 0 -0.38 37 37
cell proliferation -0.009 0.1 -9999 0 -0.34 40 40
Regulation of Telomerase

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.1 0.22 -10000 0 -0.62 48 48
RAD9A 0.018 0 -10000 0 -10000 0 0
AP1 -0.1 0.19 -10000 0 -0.43 107 107
IFNAR2 0.013 0.036 -10000 0 -0.3 6 6
AKT1 -0.053 0.12 -10000 0 -0.26 76 76
ER alpha/Oestrogen -0.12 0.18 -10000 0 -0.33 199 199
NFX1/SIN3/HDAC complex 0.038 0.048 -10000 0 -0.28 3 3
EGF -0.14 0.23 -10000 0 -0.42 193 193
SMG5 0.016 0.029 -10000 0 -0.34 3 3
SMG6 0.017 0.023 -10000 0 -0.52 1 1
SP3/HDAC2 0.019 0.041 -10000 0 -0.25 6 6
TERT/c-Abl -0.089 0.21 -10000 0 -0.58 46 46
SAP18 0.017 0.001 -10000 0 -10000 0 0
MRN complex 0.03 0.045 -10000 0 -0.3 9 9
WT1 -0.1 0.19 -10000 0 -0.35 172 172
WRN 0.012 0.049 -10000 0 -0.34 9 9
SP1 0.016 0.025 -10000 0 -0.53 1 1
SP3 0.017 0.003 -10000 0 -10000 0 0
TERF2IP 0.018 0 -10000 0 -10000 0 0
Telomerase/Nucleolin -0.099 0.17 -10000 0 -0.55 35 35
Mad/Max 0.021 0.023 -10000 0 -10000 0 0
TERT -0.1 0.23 -10000 0 -0.65 42 42
CCND1 -0.2 0.44 -10000 0 -1.1 89 89
MAX 0.017 0.004 -10000 0 -10000 0 0
RBBP7 0.01 0.051 -10000 0 -0.3 13 13
RBBP4 0.016 0.026 -10000 0 -0.39 2 2
TERF2 0.014 0.036 -10000 0 -0.46 3 3
PTGES3 0.016 0.026 -10000 0 -0.39 2 2
SIN3A 0.017 0.001 -10000 0 -10000 0 0
Telomerase/911 0.026 0.046 -10000 0 -0.35 2 2
CDKN1B -0.072 0.19 -10000 0 -0.43 84 84
RAD1 0.016 0.033 -10000 0 -0.52 2 2
XRCC5 0.018 0 -10000 0 -10000 0 0
XRCC6 0.017 0.012 -10000 0 -0.25 1 1
SAP30 0.012 0.053 -10000 0 -0.48 6 6
TRF2/PARP2 0.024 0.03 -10000 0 -0.36 3 3
UBE3A 0.015 0.033 -10000 0 -0.52 2 2
JUN -0.034 0.15 -10000 0 -0.46 57 57
E6 -0.001 0.003 -10000 0 -10000 0 0
HPV-16 E6/E6AP 0.011 0.025 -10000 0 -0.38 2 2
FOS -0.11 0.2 -10000 0 -0.37 171 171
IFN-gamma/IRF1 -0.075 0.16 -10000 0 -0.36 103 103
PARP2 0.017 0.012 -10000 0 -0.25 1 1
BLM -0.021 0.13 -10000 0 -0.4 48 48
Telomerase 0.025 0.06 -10000 0 -0.34 3 3
IRF1 -0.017 0.12 -10000 0 -0.37 40 40
ESR1 -0.16 0.24 -10000 0 -0.46 199 199
KU/TER 0.026 0.008 -10000 0 -10000 0 0
ATM/TRF2 0.025 0.023 -10000 0 -0.26 3 3
ubiquitin-dependent protein catabolic process 0.043 0.051 -10000 0 -0.35 2 2
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.043 0.052 -10000 0 -0.36 2 2
HDAC1 0.016 0.023 -10000 0 -0.52 1 1
HDAC2 0.008 0.055 -10000 0 -0.3 15 15
ATM 0.001 0.017 0.21 3 -10000 0 3
SMAD3 0.015 0.059 -10000 0 -0.36 11 11
ABL1 0.018 0 -10000 0 -10000 0 0
MXD1 0.014 0.031 -10000 0 -0.25 7 7
MRE11A 0.018 0 -10000 0 -10000 0 0
HUS1 0.016 0.02 -10000 0 -0.25 3 3
RPS6KB1 0.008 0.049 -10000 0 -0.25 18 18
TERT/NF kappa B1/14-3-3 -0.091 0.22 -10000 0 -0.57 62 62
NR2F2 -0.05 0.17 -10000 0 -0.44 79 79
MAPK3 0.019 0.041 -10000 0 -0.37 4 4
MAPK1 0.018 0.044 -10000 0 -0.37 5 5
TGFB1/TGF beta receptor Type II 0.017 0.023 -10000 0 -0.52 1 1
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
HNRNPC 0.018 0 -10000 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.001 0.017 0.21 3 -10000 0 3
NBN 0.015 0.035 -10000 0 -0.43 3 3
EGFR -0.079 0.18 -10000 0 -0.35 139 139
mol:Oestrogen 0 0.002 -10000 0 -10000 0 0
EGF/EGFR -0.15 0.2 -10000 0 -0.42 173 173
MYC -0.027 0.14 -10000 0 -0.43 52 52
IL2 0.01 0.052 -10000 0 -0.34 10 10
KU 0.026 0.008 -10000 0 -10000 0 0
RAD50 0.011 0.062 -10000 0 -0.52 7 7
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
TGFB1 0.017 0.024 -10000 0 -0.52 1 1
TRF2/BLM -0.002 0.091 -10000 0 -0.35 30 30
FRAP1 0.018 0 -10000 0 -10000 0 0
KU/TERT -0.08 0.21 -10000 0 -0.6 37 37
SP1/HDAC2 0.019 0.048 -10000 0 -0.25 11 11
PINX1 0.016 0.02 -10000 0 -0.25 3 3
Telomerase/EST1A -0.1 0.17 -10000 0 -0.55 36 36
Smad3/Myc -0.003 0.099 -10000 0 -0.31 46 46
911 complex 0.034 0.024 -10000 0 -0.3 2 2
IFNG -0.092 0.18 -10000 0 -0.33 161 161
Telomerase/PinX1 -0.099 0.17 -10000 0 -0.55 37 37
Telomerase/AKT1/mTOR/p70S6K -0.008 0.092 -10000 0 -0.47 5 5
SIN3B 0.017 0.012 -10000 0 -0.25 1 1
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
Telomerase/EST1B -0.1 0.17 -10000 0 -0.55 38 38
response to DNA damage stimulus 0.004 0.005 -10000 0 -10000 0 0
MRN complex/TRF2/Rap1 0.044 0.047 -10000 0 -0.27 11 11
TRF2/WRN 0.02 0.043 -10000 0 -0.35 6 6
Telomerase/hnRNP C1/C2 -0.099 0.17 -10000 0 -0.55 35 35
E2F1 0.005 0.071 -10000 0 -0.37 16 16
ZNFX1 0.007 0.071 -10000 0 -0.42 13 13
PIF1 0.015 0.026 -10000 0 -0.25 5 5
NCL 0.018 0 -10000 0 -10000 0 0
DKC1 0.016 0.02 -10000 0 -0.25 3 3
telomeric DNA binding 0 0 -10000 0 -10000 0 0
IFN-gamma pathway

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.012 0.1 -10000 0 -0.26 56 56
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
CRKL 0.014 0.047 -10000 0 -0.52 4 4
STAT1 (dimer)/Cbp/p300 -0.01 0.15 -10000 0 -0.45 28 28
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.015 0.061 -10000 0 -0.35 10 10
antigen processing and presentation of peptide antigen via MHC class I -0.055 0.1 -10000 0 -0.29 60 60
CaM/Ca2+ -0.007 0.097 -10000 0 -0.32 16 16
RAP1A 0.012 0.057 -10000 0 -0.52 6 6
STAT1 (dimer)/SHP2 -0.027 0.13 -10000 0 -0.35 39 39
AKT1 -0.012 0.11 -10000 0 -0.36 19 19
MAP2K1 -0.024 0.12 -10000 0 -0.34 36 36
MAP3K11 -0.011 0.098 -10000 0 -0.32 18 18
IFNGR1 0.01 0.034 -10000 0 -0.27 7 7
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.03 0.14 -10000 0 -0.42 33 33
Rap1/GTP -0.03 0.07 -10000 0 -0.33 13 13
CRKL/C3G 0.023 0.034 -10000 0 -0.37 4 4
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP -0.009 0.11 -10000 0 -0.27 52 52
CEBPB -0.01 0.16 -10000 0 -0.44 33 33
STAT3 0.015 0.04 -10000 0 -0.52 3 3
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 0.001 0.11 -10000 0 -0.67 4 4
STAT1 -0.029 0.13 -10000 0 -0.35 39 39
CALM1 0.018 0 -10000 0 -10000 0 0
IFN-gamma (dimer) -0.086 0.17 -10000 0 -0.33 161 161
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
STAT1 (dimer)/PIAS1 -0.019 0.12 -10000 0 -0.38 28 28
CEBPB/PTGES2/Cbp/p300 -0.043 0.11 -10000 0 -0.38 33 33
mol:Ca2+ -0.014 0.1 -10000 0 -0.26 56 56
MAPK3 -0.016 0.14 -10000 0 -0.46 17 17
STAT1 (dimer) -0.07 0.15 -10000 0 -0.43 55 55
MAPK1 -0.017 0.14 -10000 0 -0.49 17 17
JAK2 0.007 0.056 -10000 0 -0.34 12 12
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
JAK1 0.008 0.059 -10000 0 -0.54 6 6
CAMK2D -0.005 0.1 -10000 0 -0.4 29 29
DAPK1 0 0.14 -10000 0 -0.48 23 23
SMAD7 0.004 0.073 -10000 0 -0.18 21 21
CBL/CRKL/C3G 0.005 0.095 -10000 0 -0.35 11 11
PI3K -0.022 0.11 -10000 0 -0.36 21 21
IFNG -0.086 0.17 -10000 0 -0.33 161 161
apoptosis -0.007 0.12 0.27 2 -0.34 31 33
CAMK2G 0.017 0.017 -10000 0 -0.25 2 2
STAT3 (dimer) 0.015 0.04 -10000 0 -0.52 3 3
CAMK2A 0.017 0.023 -10000 0 -0.52 1 1
CAMK2B -0.078 0.18 -10000 0 -0.36 133 133
FRAP1 -0.004 0.1 -10000 0 -0.36 14 14
PRKCD -0.01 0.11 -10000 0 -0.36 18 18
RAP1B 0.013 0.044 -10000 0 -0.32 8 8
negative regulation of cell growth -0.055 0.1 -10000 0 -0.29 60 60
PTPN2 0.016 0.024 -10000 0 -0.25 4 4
EP300 0.014 0.047 -10000 0 -0.52 4 4
IRF1 -0.007 0.15 -10000 0 -0.47 35 35
STAT1 (dimer)/PIASy -0.024 0.13 -10000 0 -0.41 25 25
SOCS1 0.01 0.064 -10000 0 -1.4 1 1
mol:GDP 0.003 0.091 -10000 0 -0.33 11 11
CASP1 -0.017 0.12 -10000 0 -0.28 68 68
PTGES2 0.017 0.012 -10000 0 -0.25 1 1
IRF9 0.017 0.085 -10000 0 -0.31 20 20
mol:PI-3-4-5-P3 -0.048 0.089 -10000 0 -0.34 23 23
RAP1/GDP -0.03 0.071 -10000 0 -0.33 14 14
CBL -0.01 0.097 -10000 0 -0.31 19 19
MAP3K1 -0.033 0.12 -10000 0 -0.32 54 54
PIAS1 0.017 0.012 -10000 0 -0.25 1 1
PIAS4 0.012 0.05 -10000 0 -0.43 6 6
antigen processing and presentation of peptide antigen via MHC class II -0.055 0.1 -10000 0 -0.29 60 60
PTPN11 -0.019 0.1 -10000 0 -0.26 56 56
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
RAPGEF1 0.018 0 -10000 0 -10000 0 0
IL2 signaling events mediated by STAT5

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.01 0.048 -9999 0 -0.25 17 17
ELF1 -0.012 0.12 -9999 0 -0.37 44 44
CCNA2 -0.026 0.13 -9999 0 -0.39 57 57
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
JAK3 0.018 0 -9999 0 -10000 0 0
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
JAK1 0.012 0.057 -9999 0 -0.52 6 6
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.01 0.14 -9999 0 -0.43 27 27
SHC1 0.018 0.023 -9999 0 -0.52 1 1
SP1 0.015 0.07 -9999 0 -0.36 16 16
IL2RA -0.035 0.2 -9999 0 -0.68 43 43
IL2RB -0.016 0.12 -9999 0 -0.43 40 40
SOS1 0.017 0.023 -9999 0 -0.52 1 1
IL2RG -0.001 0.078 -9999 0 -0.28 35 35
G1/S transition of mitotic cell cycle -0.026 0.2 -9999 0 -0.57 47 47
PTPN11 0.018 0.023 -9999 0 -0.52 1 1
CCND2 0.009 0.14 -9999 0 -0.77 16 16
LCK -0.073 0.18 -9999 0 -0.4 117 117
GRB2 0.016 0.024 -9999 0 -0.25 4 4
IL2 0.012 0.051 -9999 0 -0.33 10 10
CDK6 -0.019 0.1 -9999 0 -0.29 63 63
CCND3 0.021 0.12 -9999 0 -0.45 13 13
Class I PI3K signaling events

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP 0.019 0.071 0.24 15 -0.24 23 38
DAPP1 -0.038 0.14 -10000 0 -0.43 42 42
Src family/SYK family/BLNK-LAT/BTK-ITK -0.051 0.22 -10000 0 -0.53 65 65
mol:DAG 0.001 0.1 0.19 9 -0.23 49 58
HRAS 0.012 0.051 -10000 0 -0.41 7 7
RAP1A 0.012 0.057 -10000 0 -0.52 6 6
ARF5/GDP -0.016 0.11 -10000 0 -0.32 30 30
PLCG2 -0.017 0.11 -10000 0 -0.32 55 55
PLCG1 0.016 0.026 -10000 0 -0.39 2 2
ARF5 0.015 0.04 -10000 0 -0.52 3 3
mol:GTP -0.006 0.068 0.22 15 -0.25 25 40
ARF1/GTP -0.006 0.067 0.22 15 -0.24 25 40
RHOA 0.005 0.08 -10000 0 -0.52 12 12
YES1 0.007 0.07 -10000 0 -0.43 12 12
RAP1A/GTP 0.015 0.069 0.22 15 -0.25 25 40
ADAP1 -0.006 0.065 0.21 15 -0.24 25 40
ARAP3 -0.006 0.067 0.22 15 -0.25 25 40
INPPL1 0.012 0.055 -10000 0 -0.44 7 7
PREX1 -0.089 0.2 -10000 0 -0.44 124 124
ARHGEF6 -0.019 0.13 -10000 0 -0.41 45 45
ARHGEF7 0.016 0.02 -10000 0 -0.25 3 3
ARF1 0.017 0.023 -10000 0 -0.52 1 1
NRAS 0.005 0.076 -10000 0 -0.4 16 16
FYN 0.008 0.067 -10000 0 -0.41 12 12
ARF6 0.016 0.033 -10000 0 -0.52 2 2
FGR 0.017 0.017 -10000 0 -0.25 2 2
mol:Ca2+ 0.006 0.054 -10000 0 -10000 0 0
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.006 0.073 -10000 0 -0.44 13 13
ZAP70 0.005 0.06 -10000 0 -0.26 24 24
mol:IP3 0.004 0.073 -10000 0 -0.18 24 24
LYN 0.014 0.031 -10000 0 -0.25 7 7
ARF1/GDP -0.015 0.1 -10000 0 -0.32 28 28
RhoA/GDP 0.003 0.099 0.23 6 -0.34 25 31
PDK1/Src/Hsp90 0.031 0.039 -10000 0 -0.3 6 6
BLNK -0.012 0.12 -10000 0 -0.51 30 30
actin cytoskeleton reorganization -0.006 0.12 0.23 6 -0.41 23 29
SRC 0.015 0.035 -10000 0 -0.43 3 3
PLEKHA2 0.014 0.043 -10000 0 -0.31 8 8
RAC1 0.018 0 -10000 0 -10000 0 0
PTEN -0.003 0.096 -10000 0 -0.5 19 19
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
ARF6/GTP 0.019 0.069 0.24 14 -0.24 21 35
RhoA/GTP 0.015 0.082 0.22 14 -0.26 32 46
Src family/SYK family/BLNK-LAT -0.032 0.17 -10000 0 -0.47 47 47
BLK -0.019 0.1 -10000 0 -0.29 63 63
PDPK1 0.016 0.026 -10000 0 -0.39 2 2
CYTH1 -0.006 0.065 0.21 15 -0.24 25 40
HCK -0.005 0.11 -10000 0 -0.47 25 25
CYTH3 -0.006 0.065 0.21 15 -0.24 25 40
CYTH2 -0.006 0.065 0.21 15 -0.24 25 40
KRAS 0.009 0.065 -10000 0 -0.44 10 10
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.025 0.052 0.18 12 -0.22 5 17
SGK1 -0.004 0.047 0.18 13 -0.21 6 19
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP -0.025 0.11 -10000 0 -0.29 41 41
SOS1 0.017 0.023 -10000 0 -0.52 1 1
SYK -0.023 0.14 -10000 0 -0.48 43 43
ARF6/GDP 0.005 0.085 0.24 6 -0.3 20 26
mol:PI-3-4-5-P3 -0.004 0.074 0.25 19 -0.25 25 44
ARAP3/RAP1A/GTP 0.014 0.07 0.22 15 -0.25 25 40
VAV1 -0.014 0.12 -10000 0 -0.39 42 42
mol:PI-3-4-P2 0.008 0.039 -10000 0 -0.32 7 7
RAS family/GTP/PI3K Class I 0.022 0.069 -10000 0 -0.25 25 25
PLEKHA1 0.012 0.052 -10000 0 -0.32 12 12
Rac1/GDP -0.014 0.1 -10000 0 -0.32 28 28
LAT 0.002 0.068 -10000 0 -0.27 29 29
Rac1/GTP -0.03 0.14 -10000 0 -0.4 42 42
ITK -0.008 0.1 0.22 14 -0.25 57 71
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.008 0.13 0.22 8 -0.32 50 58
LCK -0.074 0.18 -10000 0 -0.4 117 117
BTK 0.007 0.091 0.22 14 -0.27 37 51
Insulin Pathway

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP -0.048 0.1 -9999 0 -0.26 88 88
TC10/GTP -0.022 0.063 -9999 0 -0.23 39 39
Insulin Receptor/Insulin/IRS1/Shp2 0.005 0.11 -9999 0 -0.29 63 63
HRAS 0.012 0.051 -9999 0 -0.41 7 7
APS homodimer 0 0 -9999 0 -10000 0 0
GRB14 -0.16 0.21 -9999 0 -0.36 247 247
FOXO3 -0.021 0.065 -9999 0 -0.71 4 4
AKT1 -0.068 0.14 -9999 0 -0.37 44 44
INSR 0.015 0.038 -9999 0 -0.38 4 4
Insulin Receptor/Insulin 0.036 0.079 -9999 0 -0.49 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
GRB10 -0.003 0.097 -9999 0 -0.43 24 24
SORBS1 -0.032 0.14 -9999 0 -0.39 65 65
CRK 0.016 0.033 -9999 0 -0.52 2 2
PTPN1 0.023 0.075 -9999 0 -0.48 4 4
CAV1 -0.012 0.11 -9999 0 -0.27 69 69
CBL/APS/CAP/Crk-II/C3G 0.014 0.078 -9999 0 -0.25 35 35
Insulin Receptor/Insulin/IRS1/NCK2 0.004 0.11 -9999 0 -0.29 62 62
mol:GDP 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.011 0.11 -9999 0 -0.25 80 80
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.013 0.09 -9999 0 -0.46 6 6
RPS6KB1 -0.06 0.13 -9999 0 -0.33 50 50
PARD6A 0.004 0.081 -9999 0 -0.44 16 16
CBL 0.017 0.012 -9999 0 -0.25 1 1
tumor necrosis factor-mediated signaling pathway 0 0 -9999 0 -10000 0 0
DOK1 -0.014 0.11 -9999 0 -0.78 11 11
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.082 0.11 -9999 0 -0.33 51 51
HRAS/GTP -0.028 0.073 -9999 0 -0.33 7 7
Insulin Receptor 0.015 0.037 -9999 0 -0.38 4 4
Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.014 0.1 -9999 0 -0.26 63 63
PRKCI -0.033 0.1 -9999 0 -0.52 21 21
Insulin Receptor/Insulin/GRB14/PDK1 -0.098 0.12 -9999 0 -0.37 48 48
SHC1 0.017 0.023 -9999 0 -0.52 1 1
negative regulation of MAPKKK cascade 0.009 0.12 -9999 0 -0.67 12 12
PI3K -0.005 0.11 -9999 0 -0.26 80 80
NCK2 0.015 0.026 -9999 0 -0.25 5 5
RHOQ 0.012 0.053 -9999 0 -0.48 6 6
mol:H2O2 -0.002 0.008 -9999 0 -10000 0 0
HRAS/GDP 0.009 0.036 -9999 0 -0.29 7 7
AKT2 -0.065 0.13 -9999 0 -0.36 42 42
PRKCZ -0.028 0.074 -9999 0 -0.53 9 9
SH2B2 0 0 -9999 0 -10000 0 0
SHC/SHIP -0.002 0.093 -9999 0 -0.25 63 63
F2RL2 -0.074 0.19 -9999 0 -0.44 105 105
TRIP10 0.013 0.048 -9999 0 -0.47 5 5
Insulin Receptor/Insulin/Shc 0.032 0.029 -9999 0 -0.27 4 4
TC10/GTP/CIP4/Exocyst 0.018 0.045 -9999 0 -0.31 9 9
Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.05 0.036 -9999 0 -0.38 2 2
RAPGEF1 0.018 0 -9999 0 -10000 0 0
RASA1 0.004 0.078 -9999 0 -0.42 16 16
NCK1 0.011 0.045 -9999 0 -0.28 12 12
CBL/APS/CAP/Crk-II 0.005 0.082 -9999 0 -0.28 35 35
TC10/GDP 0.009 0.039 -9999 0 -0.34 6 6
Insulin Receptor/Insulin/SHC/GRB10 0.032 0.064 -9999 0 -0.27 20 20
INPP5D -0.014 0.096 -9999 0 -0.27 62 62
SOS1 0.017 0.023 -9999 0 -0.52 1 1
SGK1 -0.01 0.012 -9999 0 -10000 0 0
mol:cAMP 0 0 -9999 0 -10000 0 0
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
IRS1 -0.048 0.17 -9999 0 -0.49 68 68
p62DOK/RasGAP 0.009 0.12 -9999 0 -0.68 12 12
INS 0.017 0.025 -9999 0 -0.52 1 1
mol:PI-3-4-P2 -0.013 0.096 -9999 0 -0.27 62 62
GRB2 0.016 0.024 -9999 0 -0.25 4 4
EIF4EBP1 -0.067 0.13 -9999 0 -0.34 57 57
PTPRA 0.017 0.028 -9999 0 -0.4 2 2
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
TC10/GTP/CIP4 0.018 0.045 -9999 0 -0.31 9 9
PDPK1 0.016 0.026 -9999 0 -0.39 2 2
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.009 0.095 -9999 0 -0.4 6 6
Insulin Receptor/Insulin/IRS1 -0.006 0.11 -9999 0 -0.29 62 62
Insulin Receptor/Insulin/IRS3 0.024 0.034 -9999 0 -0.37 3 3
Par3/Par6 -0.02 0.13 -9999 0 -0.29 86 86
E-cadherin signaling in keratinocytes

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.011 0.088 -10000 0 -0.29 23 23
adherens junction organization -0.013 0.11 -10000 0 -0.25 78 78
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.019 0.11 -10000 0 -0.34 21 21
FMN1 -0.008 0.1 -10000 0 -0.24 78 78
mol:IP3 0.006 0.081 -10000 0 -0.25 23 23
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.008 0.11 -10000 0 -0.25 78 78
CTNNB1 0.002 0.09 -10000 0 -0.45 19 19
AKT1 0.007 0.092 -10000 0 -0.33 11 11
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.018 0.15 -10000 0 -0.38 76 76
CTNND1 0.016 0.029 -10000 0 -0.34 3 3
mol:PI-4-5-P2 0 0.1 -10000 0 -0.33 10 10
VASP -0.007 0.11 -10000 0 -0.32 20 20
ZYX -0.006 0.11 -10000 0 -0.36 13 13
JUB -0.023 0.13 -10000 0 -0.39 21 21
EGFR(dimer) -0.043 0.13 -10000 0 -0.35 32 32
E-cadherin/beta catenin-gamma catenin -0.019 0.12 -10000 0 -0.3 78 78
mol:PI-3-4-5-P3 0.003 0.092 -10000 0 -0.26 28 28
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
PI3K 0.004 0.093 -10000 0 -0.26 28 28
FYN 0.015 0.085 -10000 0 -0.3 15 15
mol:Ca2+ 0.006 0.08 -10000 0 -0.24 23 23
JUP 0.012 0.056 -10000 0 -0.42 8 8
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
mol:DAG 0.006 0.081 -10000 0 -0.25 23 23
CDH1 -0.049 0.17 -10000 0 -0.48 70 70
RhoA/GDP -0.025 0.12 -10000 0 -0.35 28 28
establishment of polarity of embryonic epithelium -0.006 0.11 -10000 0 -0.32 20 20
SRC 0.015 0.035 -10000 0 -0.43 3 3
RAC1 0.018 0 -10000 0 -10000 0 0
RHOA 0.005 0.08 -10000 0 -0.52 12 12
EGFR -0.079 0.18 -10000 0 -0.35 139 139
CASR 0.012 0.078 -10000 0 -0.31 7 7
RhoA/GTP 0.008 0.086 -10000 0 -0.32 11 11
AKT2 0.009 0.087 -10000 0 -0.32 7 7
actin cable formation -0.007 0.1 -10000 0 -0.31 20 20
apoptosis -0.006 0.089 0.26 26 -10000 0 26
CTNNA1 0.017 0.024 -10000 0 -0.52 1 1
mol:GDP -0.03 0.12 -10000 0 -0.36 22 22
PIP5K1A -0.001 0.1 -10000 0 -0.34 10 10
PLCG1 0.006 0.082 -10000 0 -0.25 23 23
Rac1/GTP -0.034 0.12 -10000 0 -0.32 31 31
homophilic cell adhesion 0 0.003 -10000 0 -10000 0 0
p75(NTR)-mediated signaling

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.019 0.05 -10000 0 -0.37 8 8
Necdin/E2F1 -0.027 0.14 -10000 0 -0.38 62 62
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E -0.01 0.11 -10000 0 -0.27 78 78
NGF (dimer)/p75(NTR)/BEX1 -0.016 0.075 -10000 0 -0.29 12 12
NT-4/5 (dimer)/p75(NTR) 0.004 0.045 -10000 0 -0.2 23 23
IKBKB 0.012 0.047 -10000 0 -0.31 10 10
AKT1 0.01 0.072 -10000 0 -0.25 30 30
IKBKG 0.018 0 -10000 0 -10000 0 0
BDNF -0.016 0.091 -10000 0 -0.26 64 64
MGDIs/NGR/p75(NTR)/LINGO1 -0.003 0.086 -10000 0 -0.31 22 22
FURIN 0.004 0.076 -10000 0 -0.37 19 19
proBDNF (dimer)/p75(NTR)/Sortilin 0.004 0.075 -10000 0 -0.33 11 11
LINGO1 -0.019 0.095 -10000 0 -0.26 69 69
Sortilin/TRAF6/NRIF -0.017 0.056 -10000 0 -0.33 5 5
proBDNF (dimer) -0.016 0.09 -10000 0 -0.26 64 64
NTRK1 0.01 0.053 -10000 0 -0.32 12 12
RTN4R 0.001 0.087 -10000 0 -0.41 21 21
neuron apoptosis 0.003 0.1 -10000 0 -0.43 9 9
IRAK1 0.015 0.029 -10000 0 -0.25 6 6
SHC1 0.013 0.04 -10000 0 -0.31 4 4
ARHGDIA 0.016 0.029 -10000 0 -0.34 3 3
RhoA/GTP 0.004 0.058 -10000 0 -0.38 12 12
Gamma Secretase 0.033 0.069 -10000 0 -0.25 25 25
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.001 0.095 -10000 0 -0.3 43 43
MAGEH1 -0.019 0.14 -10000 0 -0.52 36 36
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.013 0.11 -10000 0 -0.3 65 65
Mammalian IAPs/DIABLO -0.024 0.11 -10000 0 -0.28 76 76
proNGF (dimer) 0 0 -10000 0 -10000 0 0
MAGED1 -0.008 0.11 -10000 0 -0.48 27 27
APP -0.029 0.14 -10000 0 -0.43 56 56
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
ZNF274 0.013 0.044 -10000 0 -0.32 8 8
RhoA/GDP/RHOGDI 0.017 0.057 -10000 0 -0.27 16 16
NGF 0 0 -10000 0 -10000 0 0
cell cycle arrest 0.006 0.054 0.15 3 -0.26 10 13
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.026 0.04 -10000 0 -0.23 9 9
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.016 0.041 -10000 0 -0.31 4 4
NCSTN 0.017 0.023 -10000 0 -0.52 1 1
mol:GTP -0.016 0.089 -10000 0 -0.31 31 31
PSENEN 0.017 0.012 -10000 0 -0.25 1 1
mol:ceramide 0.014 0.056 -10000 0 -0.29 12 12
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.022 0.049 -10000 0 -0.19 22 22
p75(NTR)/beta APP -0.017 0.11 -10000 0 -0.37 39 39
BEX1 -0.039 0.11 -10000 0 -0.26 108 108
mol:GDP 0.002 0.037 -10000 0 -0.16 23 23
NGF (dimer) -0.038 0.13 -10000 0 -0.29 101 101
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.009 0.081 -10000 0 -0.28 23 23
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
RAC1/GTP 0.015 0.032 -10000 0 -0.27 3 3
MYD88 0.013 0.048 -10000 0 -0.47 5 5
CHUK 0.005 0.081 -10000 0 -0.5 13 13
NGF (dimer)/p75(NTR)/PKA -0.016 0.09 -10000 0 -0.31 31 31
RHOB -0.041 0.17 -10000 0 -0.52 58 58
RHOA 0.005 0.08 -10000 0 -0.52 12 12
MAGE-G1/E2F1 0.018 0.051 -10000 0 -0.37 7 7
NT3 (dimer) -0.021 0.11 -10000 0 -0.28 68 68
TP53 -0.001 0.098 -10000 0 -0.26 49 49
PRDM4 0.017 0.049 -10000 0 -0.28 10 10
BDNF (dimer) -0.12 0.2 -10000 0 -0.37 173 173
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
SORT1 0.009 0.065 -10000 0 -0.44 10 10
activation of caspase activity -0.013 0.11 -10000 0 -0.27 78 78
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.022 0.052 -10000 0 -0.28 11 11
RHOC 0.015 0.04 -10000 0 -0.52 3 3
XIAP 0 0 -10000 0 -10000 0 0
MAPK10 0 0.095 -10000 0 -0.29 22 22
DIABLO 0.018 0 -10000 0 -10000 0 0
SMPD2 0.014 0.056 -10000 0 -0.3 12 12
APH1B 0.001 0.093 -10000 0 -0.51 17 17
APH1A 0.003 0.067 -10000 0 -0.29 25 25
proNGF (dimer)/p75(NTR)/Sortilin 0.011 0.055 -10000 0 -0.31 10 10
PSEN1 0.013 0.052 -10000 0 -0.52 5 5
APAF-1/Pro-Caspase 9 0.022 0.041 -10000 0 -0.37 5 5
NT3 (dimer)/p75(NTR) -0.009 0.09 -10000 0 -0.4 13 13
MAPK8 0.014 0.08 -10000 0 -0.28 11 11
MAPK9 0.005 0.096 -10000 0 -0.31 20 20
APAF1 0.012 0.051 -10000 0 -0.41 7 7
NTF3 -0.021 0.11 -10000 0 -0.28 68 68
NTF4 0 0 -10000 0 -10000 0 0
NDN -0.044 0.17 -10000 0 -0.49 65 65
RAC1/GDP 0.013 0 -10000 0 -10000 0 0
RhoA-B-C/GDP -0.028 0.12 -10000 0 -0.25 96 96
p75 CTF/Sortilin/TRAF6/NRIF 0.036 0.048 -10000 0 -0.27 10 10
RhoA-B-C/GTP -0.016 0.089 -10000 0 -0.31 31 31
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.021 0.07 -10000 0 -0.26 14 14
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.015 0.071 -10000 0 -0.29 12 12
PRKACB -0.036 0.14 -10000 0 -0.34 79 79
proBDNF (dimer)/p75 ECD 0.002 0.064 -10000 0 -0.34 2 2
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 -0.085 0.19 -10000 0 -0.41 128 128
BIRC2 0.016 0.02 -10000 0 -0.25 3 3
neuron projection morphogenesis -0.033 0.11 0.2 2 -0.3 50 52
BAD 0.008 0.091 -10000 0 -0.29 17 17
RIPK2 0.013 0.04 -10000 0 -0.28 9 9
NGFR 0.004 0.065 -10000 0 -0.29 23 23
CYCS 0.01 0.074 -10000 0 -0.25 34 34
ADAM17 0.016 0.024 -10000 0 -0.25 4 4
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.024 0.044 -10000 0 -0.27 6 6
BCL2L11 0.008 0.091 -10000 0 -0.29 17 17
BDNF (dimer)/p75(NTR) -0.006 0.075 -10000 0 -0.4 4 4
PI3K 0.011 0.072 -10000 0 -0.28 25 25
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.022 0.05 -10000 0 -0.28 10 10
NDNL2 0.018 0 -10000 0 -10000 0 0
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
PRKCI 0.002 0.085 -10000 0 -0.43 18 18
NGF (dimer)/p75(NTR) 0.004 0.045 -10000 0 -0.2 23 23
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.008 0.08 -10000 0 -0.28 33 33
TRAF6 0.017 0.023 -10000 0 -0.52 1 1
RAC1 0.018 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
PLG 0.016 0.033 -10000 0 -0.52 2 2
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 0.005 0.07 -10000 0 -0.28 18 18
SQSTM1 0.012 0.053 -10000 0 -0.48 6 6
NGFRAP1 -0.055 0.18 -10000 0 -0.52 72 72
CASP3 0.01 0.087 -10000 0 -0.27 17 17
E2F1 0.006 0.07 -10000 0 -0.37 16 16
CASP9 0.017 0.023 -10000 0 -0.52 1 1
IKK complex -0.013 0.047 -10000 0 -0.34 3 3
NGF (dimer)/TRKA 0.008 0.037 -10000 0 -0.22 12 12
MMP7 -0.095 0.21 -10000 0 -0.44 129 129
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.028 0.054 -10000 0 -0.25 13 13
MMP3 -0.13 0.22 -10000 0 -0.42 177 177
APAF-1/Caspase 9 -0.046 0.077 -10000 0 -0.31 10 10
Ceramide signaling pathway

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.01 0.074 -10000 0 -0.37 18 18
MAP4K4 -0.003 0.11 -10000 0 -0.45 12 12
BAG4 0.002 0.07 -10000 0 -0.28 28 28
PKC zeta/ceramide -0.025 0.04 0.13 8 -0.12 1 9
NFKBIA 0.014 0.042 -10000 0 -0.45 4 4
BIRC3 -0.085 0.19 -10000 0 -0.41 128 128
BAX -0.003 0.022 -10000 0 -10000 0 0
RIPK1 0.017 0.023 -10000 0 -0.52 1 1
AKT1 0.017 0.051 -10000 0 -0.34 9 9
BAD -0.018 0.041 0.14 10 -0.18 1 11
SMPD1 0.008 0.06 -10000 0 -0.24 19 19
RB1 -0.028 0.07 0.15 8 -0.32 20 28
FADD/Caspase 8 0.007 0.1 -10000 0 -0.43 11 11
MAP2K4 -0.043 0.092 0.15 5 -0.28 55 60
NSMAF 0.009 0.065 -10000 0 -0.44 10 10
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.01 0.04 0.15 4 -0.18 1 5
EGF -0.14 0.23 -10000 0 -0.42 193 193
mol:ceramide -0.027 0.044 0.14 11 -0.12 1 12
MADD 0.018 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid -0.028 0.13 -10000 0 -0.38 56 56
ASAH1 -0.036 0.15 -10000 0 -0.42 65 65
negative regulation of cell cycle -0.027 0.069 0.15 8 -0.31 20 28
cell proliferation -0.036 0.097 -10000 0 -0.23 83 83
BID -0.013 0.12 -10000 0 -0.55 17 17
MAP3K1 -0.041 0.084 0.15 7 -0.3 38 45
EIF2A -0.013 0.059 0.15 1 -0.26 15 16
TRADD 0.016 0.026 -10000 0 -0.39 2 2
CRADD 0.01 0.063 -10000 0 -0.49 8 8
MAPK3 0.002 0.039 0.16 1 -0.19 1 2
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 0.001 0.04 -10000 0 -0.19 1 1
Cathepsin D/ceramide -0.022 0.055 0.14 7 -0.22 12 19
FADD -0.006 0.11 -10000 0 -0.38 19 19
KSR1 -0.017 0.042 0.15 8 -0.2 1 9
MAPK8 -0.03 0.069 0.14 5 -0.2 51 56
PRKRA -0.017 0.042 0.15 8 -10000 0 8
PDGFA -0.003 0.099 -10000 0 -0.44 24 24
TRAF2 0.014 0.042 -10000 0 -0.45 4 4
IGF1 -0.1 0.2 -10000 0 -0.41 146 146
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.026 0.044 0.14 11 -0.12 1 12
CTSD 0.002 0.075 -10000 0 -0.32 24 24
regulation of nitric oxide biosynthetic process 0.026 0.017 -10000 0 -0.37 1 1
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.035 0.11 -10000 0 -0.25 81 81
PRKCD 0.014 0.042 -10000 0 -0.45 4 4
PRKCZ 0 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine -0.028 0.13 -10000 0 -0.38 56 56
RelA/NF kappa B1 0.026 0.017 -10000 0 -0.37 1 1
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0 0.091 -10000 0 -0.44 20 20
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.005 0.11 -10000 0 -0.45 13 13
TNFR1A/BAG4/TNF-alpha 0.012 0.074 -10000 0 -0.31 18 18
mol:Sphingosine-1-phosphate 0.01 0.074 -10000 0 -0.37 18 18
MAP2K1 -0.002 0.039 -10000 0 -10000 0 0
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.018 0 -10000 0 -10000 0 0
CYCS 0.027 0.065 0.16 76 -10000 0 76
TNFRSF1A 0.016 0.033 -10000 0 -0.52 2 2
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
TNFR1A/BAG4 0.014 0.054 -10000 0 -0.37 5 5
EIF2AK2 -0.02 0.061 0.15 7 -0.26 18 25
TNF-alpha/TNFR1A/FAN 0.016 0.073 -10000 0 -0.31 21 21
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.02 0.062 -10000 0 -0.3 2 2
MAP2K2 -0.003 0.043 -10000 0 -0.27 3 3
SMPD3 0.005 0.072 -10000 0 -0.26 20 20
TNF -0.004 0.094 -10000 0 -0.36 31 31
PKC zeta/PAR4 0.001 0.065 -10000 0 -0.32 20 20
mol:PHOSPHOCHOLINE 0.055 0.1 0.22 129 -10000 0 129
NF kappa B1/RelA/I kappa B alpha 0.03 0.055 -10000 0 -0.25 18 18
AIFM1 0.027 0.065 0.16 76 -10000 0 76
BCL2 -0.11 0.22 -10000 0 -0.47 144 144
Aurora B signaling

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex 0.01 0.079 -9999 0 -0.29 23 23
STMN1 0.002 0.088 -9999 0 -0.38 22 22
Aurora B/RasGAP/Survivin -0.011 0.12 -9999 0 -0.34 53 53
Chromosomal passenger complex/Cul3 protein complex -0.052 0.14 -9999 0 -0.35 57 57
BIRC5 -0.038 0.16 -9999 0 -0.43 67 67
DES -0.026 0.13 -9999 0 -0.68 16 16
Aurora C/Aurora B/INCENP 0.015 0.062 -9999 0 -0.29 14 14
Aurora B/TACC1 -0.005 0.088 -9999 0 -0.32 32 32
Aurora B/PP2A 0.019 0.042 -9999 0 -0.39 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
CBX5 0.011 0.033 -9999 0 -0.21 9 9
mitotic metaphase/anaphase transition 0 0.005 -9999 0 -10000 0 0
NDC80 -0.014 0.12 -9999 0 -0.4 39 39
Cul3 protein complex -0.048 0.14 -9999 0 -0.33 93 93
KIF2C -0.061 0.24 -9999 0 -0.65 59 59
PEBP1 0.013 0.047 -9999 0 -0.53 4 4
KIF20A -0.027 0.14 -9999 0 -0.46 49 49
mol:GDP 0 0 -9999 0 -10000 0 0
Aurora B/RasGAP 0.011 0.07 -9999 0 -0.38 13 13
SEPT1 0.008 0.052 -9999 0 -0.27 17 17
SMC2 0.003 0.077 -9999 0 -0.36 20 20
SMC4 0.014 0.04 -9999 0 -0.34 6 6
NSUN2/NPM1/Nucleolin 0.015 0.082 -9999 0 -0.87 3 3
PSMA3 0.017 0.012 -9999 0 -0.25 1 1
G2/M transition of mitotic cell cycle 0 0.003 -9999 0 -10000 0 0
H3F3B 0.013 0.04 -9999 0 -0.33 5 5
AURKB 0.009 0.058 -9999 0 -0.32 14 14
AURKC 0.008 0.053 -9999 0 -0.27 18 18
CDCA8 -0.016 0.12 -9999 0 -0.4 42 42
cytokinesis -0.049 0.26 -9999 0 -0.74 49 49
Aurora B/Septin1 -0.036 0.23 -9999 0 -0.7 45 45
AURKA -0.012 0.11 -9999 0 -0.41 36 36
INCENP 0.001 0.082 -9999 0 -0.37 22 22
KLHL13 -0.095 0.2 -9999 0 -0.39 146 146
BUB1 -0.052 0.17 -9999 0 -0.44 81 81
hSgo1/Aurora B/Survivin -0.016 0.14 -9999 0 -0.38 52 52
EVI5 0.013 0.047 -9999 0 -0.52 4 4
RhoA/GTP -0.045 0.24 -9999 0 -0.65 57 57
SGOL1 -0.01 0.11 -9999 0 -0.38 37 37
CENPA -0.041 0.21 -9999 0 -0.6 50 50
NCAPG 0 0 -9999 0 -10000 0 0
Aurora B/HC8 Proteasome 0.02 0.041 -9999 0 -0.39 3 3
NCAPD2 0.012 0.04 -9999 0 -0.25 12 12
Aurora B/PP1-gamma 0.018 0.05 -9999 0 -0.38 6 6
RHOA 0.005 0.08 -9999 0 -0.52 12 12
NCAPH -0.008 0.11 -9999 0 -0.46 29 29
NPM1 0.012 0.052 -9999 0 -0.6 3 3
RASA1 0.004 0.078 -9999 0 -0.42 16 16
KLHL9 -0.001 0.096 -9999 0 -0.49 19 19
mitotic prometaphase -0.001 0.005 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.02 0.041 -9999 0 -0.38 3 3
PPP1CC 0.015 0.04 -9999 0 -0.52 3 3
Centraspindlin -0.053 0.27 -9999 0 -0.69 60 60
RhoA/GDP 0.004 0.058 -9999 0 -0.38 12 12
NSUN2 0.012 0.054 -9999 0 -0.6 3 3
MYLK 0.003 0.07 -9999 0 -0.33 20 20
KIF23 -0.024 0.14 -9999 0 -0.45 47 47
VIM -0.01 0.11 -9999 0 -0.38 34 34
RACGAP1 -0.004 0.1 -9999 0 -0.5 22 22
mitosis 0 0 -9999 0 -10000 0 0
NCL 0.013 0.052 -9999 0 -0.6 3 3
Chromosomal passenger complex -0.045 0.22 -9999 0 -0.59 54 54
Chromosomal passenger complex/EVI5 -0.012 0.15 -9999 0 -0.36 62 62
TACC1 -0.022 0.13 -9999 0 -0.41 49 49
PPP2R5D 0.016 0.02 -9999 0 -0.25 3 3
CUL3 0.01 0.06 -9999 0 -0.43 9 9
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
RXR and RAR heterodimerization with other nuclear receptor

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.003 0.062 -9999 0 -1.2 1 1
VDR -0.003 0.1 -9999 0 -0.51 21 21
FAM120B 0.016 0.033 -9999 0 -0.52 2 2
RXRs/LXRs/DNA/9cRA 0.012 0.13 -9999 0 -0.41 22 22
RXRs/LXRs/DNA/Oxysterols -0.001 0.18 -9999 0 -0.44 69 69
MED1 0 0.067 -9999 0 -0.25 34 34
mol:9cRA -0.001 0.021 -9999 0 -10000 0 0
RARs/THRs/DNA/Src-1 -0.003 0.11 -9999 0 -0.43 16 16
RXRs/NUR77 0.031 0.076 -9999 0 -0.28 19 19
RXRs/PPAR 0.008 0.093 -9999 0 -0.34 17 17
NCOR2 0.018 0 -9999 0 -10000 0 0
VDR/VDR/Vit D3 -0.002 0.075 -9999 0 -0.37 21 21
RARs/VDR/DNA/Vit D3 0.004 0.095 -9999 0 -0.27 47 47
RARA 0.011 0.057 -9999 0 -0.4 9 9
NCOA1 0.012 0.057 -9999 0 -0.52 6 6
VDR/VDR/DNA -0.003 0.1 -9999 0 -0.51 21 21
RARs/RARs/DNA/9cRA 0.005 0.077 -9999 0 -0.27 29 29
RARG 0.017 0.023 -9999 0 -0.52 1 1
RPS6KB1 0.004 0.055 -9999 0 -0.24 19 19
RARs/THRs/DNA/SMRT 0 0.1 -9999 0 -0.27 57 57
THRA -0.01 0.11 -9999 0 -0.38 37 37
mol:Bile acids 0 0 -9999 0 -10000 0 0
VDR/Vit D3/DNA -0.002 0.075 -9999 0 -0.37 21 21
RXRs/PPAR/9cRA/PGJ2/DNA 0.022 0.084 -9999 0 -0.29 18 18
NR1H4 0.015 0.031 -9999 0 -0.32 4 4
RXRs/LXRs/DNA 0.037 0.11 -9999 0 -0.42 10 10
NR1H2 0.018 0.017 -9999 0 -10000 0 0
NR1H3 0.008 0.07 -9999 0 -0.44 11 11
RXRs/VDR/DNA/Vit D3 0.021 0.088 -9999 0 -0.27 37 37
NR4A1 0.01 0.049 -9999 0 -0.27 15 15
mol:ATRA 0 0 -9999 0 -10000 0 0
RXRs/FXR/9cRA/MED1 0.016 0.063 -9999 0 -0.26 9 9
RXRG 0.004 0.084 -9999 0 -0.47 15 15
RXR alpha/CCPG 0.023 0.041 -9999 0 -0.38 5 5
RXRA 0.014 0.045 -9999 0 -0.54 3 3
RXRB 0.014 0.045 -9999 0 -0.52 3 3
THRB -0.001 0.097 -9999 0 -0.48 20 20
PPARG -0.036 0.14 -9999 0 -0.33 81 81
PPARD 0.017 0.017 -9999 0 -0.25 2 2
TNF -0.01 0.23 -9999 0 -0.8 28 28
mol:Oxysterols 0 0.018 -9999 0 -10000 0 0
cholesterol transport 0 0.18 -9999 0 -0.43 69 69
PPARA 0.012 0.047 -9999 0 -0.31 10 10
mol:Vit D3 0 0 -9999 0 -10000 0 0
RARB -0.025 0.13 -9999 0 -0.36 60 60
RXRs/NUR77/BCL2 -0.04 0.12 -9999 0 -0.24 130 130
SREBF1 -0.052 0.33 -9999 0 -1 51 51
RXRs/RXRs/DNA/9cRA 0.022 0.084 -9999 0 -0.29 18 18
ABCA1 -0.01 0.24 -9999 0 -0.83 29 29
RARs/THRs 0.001 0.12 -9999 0 -0.29 57 57
RXRs/FXR 0.034 0.074 -9999 0 -0.28 19 19
BCL2 -0.11 0.22 -9999 0 -0.47 144 144
Effects of Botulinum toxin

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A 0.009 0.027 -9999 0 -0.17 12 12
UniProt:P19321 0 0 -9999 0 -10000 0 0
RIMS1/UNC13B 0.007 0.062 -9999 0 -0.4 3 3
STXBP1 0.017 0.017 -9999 0 -0.25 2 2
ACh/CHRNA1 0.008 0.046 -9999 0 -0.34 7 7
RAB3GAP2/RIMS1/UNC13B 0.019 0.054 -9999 0 -0.32 4 4
mol:Ca2+ 0 0 -9999 0 -10000 0 0
UniProt:P30996 0 0 -9999 0 -10000 0 0
UniProt:Q60393 0 0 -9999 0 -10000 0 0
CST086 0 0 -9999 0 -10000 0 0
RIMS1 -0.003 0.073 -9999 0 -0.25 41 41
mol:ACh 0.002 0.026 -9999 0 -0.1 24 24
RAB3GAP2 0.017 0.023 -9999 0 -0.52 1 1
STX1A/SNAP25/VAMP2 0.018 0.053 -9999 0 -0.25 3 3
UniProt:P10844 0 0 -9999 0 -10000 0 0
muscle contraction 0.008 0.046 -9999 0 -0.34 7 7
UNC13B 0.011 0.049 -9999 0 -0.3 12 12
CHRNA1 0.01 0.064 -9999 0 -0.46 9 9
UniProt:P10845 0 0 -9999 0 -10000 0 0
ACh/Synaptotagmin 1 -0.1 0.14 -9999 0 -0.22 265 265
SNAP25 -0.008 0.055 -9999 0 -0.29 15 15
VAMP2 0.007 0.011 -9999 0 -0.26 1 1
SYT1 -0.17 0.21 -9999 0 -0.36 265 265
UniProt:Q00496 0 0 -9999 0 -10000 0 0
STXIA/STXBP1 0.019 0.026 -9999 0 -0.27 1 1
STX1A/SNAP25 fragment 1/VAMP2 0.018 0.053 -9999 0 -0.25 3 3
TCGA08_rtk_signaling

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.017 0.13 -10000 0 -0.48 37 37
HRAS 0.012 0.051 -10000 0 -0.41 7 7
EGFR -0.079 0.18 -10000 0 -0.35 139 139
AKT 0.014 0.079 -10000 0 -0.27 24 24
FOXO3 0.011 0.053 -10000 0 -0.37 9 9
AKT1 0.011 0.053 -10000 0 -0.37 9 9
FOXO1 0 0.092 -10000 0 -0.46 19 19
AKT3 -0.006 0.084 -10000 0 -0.28 43 43
FOXO4 0.017 0.023 -10000 0 -0.52 1 1
MET 0 0.075 -10000 0 -0.29 31 31
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
PIK3CB 0.012 0.055 -10000 0 -0.44 7 7
NRAS 0.005 0.076 -10000 0 -0.4 16 16
PIK3CG -0.007 0.1 -10000 0 -0.41 31 31
PIK3R3 0 0.091 -10000 0 -0.43 21 21
PIK3R2 0.018 0 -10000 0 -10000 0 0
NF1 0.015 0.035 -10000 0 -0.43 3 3
RAS -0.027 0.097 0.21 1 -0.27 47 48
ERBB2 -0.027 0.12 -10000 0 -0.31 72 72
proliferation/survival/translation -0.028 0.057 0.23 10 -0.17 3 13
PI3K -0.019 0.099 0.18 5 -0.24 62 67
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
KRAS 0.009 0.065 -10000 0 -0.44 10 10
FOXO 0.039 0.038 -10000 0 -0.18 2 2
AKT2 0.017 0.012 -10000 0 -0.25 1 1
PTEN -0.002 0.1 -10000 0 -0.52 19 19
FOXA2 and FOXA3 transcription factor networks

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL 0.019 0.27 -9999 0 -0.76 29 29
PCK1 0.019 0.2 -9999 0 -1 5 5
HNF4A 0.033 0.27 -9999 0 -0.84 14 14
KCNJ11 -0.015 0.38 -9999 0 -1 49 49
AKT1 0.011 0.17 -9999 0 -0.44 29 29
response to starvation 0.006 0.003 -9999 0 -10000 0 0
DLK1 0.019 0.3 -9999 0 -0.78 28 28
NKX2-1 0.074 0.14 -9999 0 -10000 0 0
ACADM 0.01 0.29 -9999 0 -0.77 35 35
TAT 0.018 0.17 -9999 0 -0.55 7 7
CEBPB 0.01 0.071 -9999 0 -0.33 20 20
CEBPA 0.011 0.085 -9999 0 -0.5 14 14
TTR -0.041 0.28 -9999 0 -0.75 39 39
PKLR 0.022 0.26 -9999 0 -0.72 27 27
APOA1 0.032 0.3 -9999 0 -0.84 23 23
CPT1C 0 0.3 -9999 0 -0.85 35 35
ALAS1 0.039 0.19 -9999 0 -1.6 2 2
TFRC -0.047 0.39 -9999 0 -1.1 47 47
FOXF1 -0.002 0.062 -9999 0 -0.3 19 19
NF1 0.023 0.039 -9999 0 -0.46 3 3
HNF1A (dimer) 0.03 0.047 -9999 0 -0.24 6 6
CPT1A 0.007 0.3 -9999 0 -0.84 33 33
HMGCS1 0.018 0.27 -9999 0 -0.73 28 28
NR3C1 0.007 0.1 -9999 0 -0.5 19 19
CPT1B 0.022 0.26 -9999 0 -0.74 25 25
chromatin remodeling 0 0 -9999 0 -10000 0 0
SP1 0.02 0.04 -9999 0 -0.25 8 8
GCK 0.017 0.27 -9999 0 -0.73 31 31
CREB1 0.02 0.036 -9999 0 -0.51 1 1
IGFBP1 0.028 0.16 -9999 0 -0.73 4 4
PDX1 0.035 0.26 -9999 0 -1.2 13 13
UCP2 -0.025 0.35 -9999 0 -0.9 52 52
ALDOB 0.024 0.29 -9999 0 -0.79 26 26
AFP -0.049 0.15 -9999 0 -0.45 20 20
BDH1 0.011 0.28 -9999 0 -0.75 35 35
HADH 0.021 0.3 -9999 0 -0.81 29 29
F2 0.032 0.3 -9999 0 -0.92 14 14
HNF1A 0.03 0.047 -9999 0 -0.24 6 6
G6PC 0.035 0.096 -9999 0 -1.3 1 1
SLC2A2 0.042 0.22 -9999 0 -1.1 5 5
INS 0.002 0.028 -9999 0 -0.53 1 1
FOXA1 -0.081 0.21 -9999 0 -0.5 104 104
FOXA3 -0.016 0.13 -9999 0 -0.38 31 31
FOXA2 0.032 0.35 -9999 0 -0.86 32 32
ABCC8 -0.2 0.52 -9999 0 -0.91 167 167
ALB -0.055 0.17 -9999 0 -0.67 16 16
Regulation of Androgen receptor activity

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.025 0.017 -9999 0 -0.37 1 1
SMARCC1 -0.003 0.12 -9999 0 -1.3 4 4
REL 0 0.087 -9999 0 -0.41 21 21
HDAC7 -0.025 0.13 -9999 0 -0.39 30 30
JUN -0.033 0.15 -9999 0 -0.46 57 57
EP300 0.014 0.047 -9999 0 -0.52 4 4
KAT2B 0 0 -9999 0 -10000 0 0
KAT5 0 0 -9999 0 -10000 0 0
MAPK14 0.002 0.084 -9999 0 -0.36 22 22
FOXO1 0.001 0.092 -9999 0 -0.46 19 19
T-DHT/AR -0.019 0.15 -9999 0 -0.41 30 30
MAP2K6 -0.013 0.11 -9999 0 -0.4 37 37
BRM/BAF57 0.026 0.028 -9999 0 -0.37 2 2
MAP2K4 -0.007 0.1 -9999 0 -0.39 31 31
SMARCA2 0.016 0.033 -9999 0 -0.52 2 2
PDE9A -0.026 0.16 -9999 0 -0.8 11 11
NCOA2 0.01 0.063 -9999 0 -0.4 11 11
CEBPA 0.004 0.084 -9999 0 -0.5 14 14
EHMT2 0.018 0.001 -9999 0 -10000 0 0
cell proliferation 0.007 0.13 -9999 0 -0.36 23 23
NR0B1 -0.01 0.087 -9999 0 -0.27 51 51
EGR1 -0.1 0.2 -9999 0 -0.39 156 156
RXRs/9cRA 0.025 0.057 -9999 0 -0.28 18 18
AR/RACK1/Src 0.003 0.1 -9999 0 -0.34 20 20
AR/GR -0.038 0.13 -9999 0 -0.29 73 73
GNB2L1 0.015 0.04 -9999 0 -0.52 3 3
PKN1 0.013 0.045 -9999 0 -0.39 6 6
RCHY1 0.002 0.09 -9999 0 -0.5 16 16
epidermal growth factor receptor activity 0 0.001 -9999 0 -0.005 6 6
MAPK8 0.004 0.08 -9999 0 -0.38 18 18
T-DHT/AR/TIF2/CARM1 0 0.11 -9999 0 -0.36 22 22
SRC 0.005 0.09 -9999 0 -0.28 38 38
NR3C1 -0.001 0.098 -9999 0 -0.51 19 19
KLK3 -0.038 0.11 -9999 0 -0.46 6 6
APPBP2 0.009 0.042 -9999 0 -0.25 13 13
TRIM24 0.017 0.024 -9999 0 -0.25 4 4
T-DHT/AR/TIP60 -0.021 0.1 -9999 0 -0.31 42 42
TMPRSS2 -0.18 0.43 -9999 0 -1.1 95 95
RXRG 0.004 0.083 -9999 0 -0.47 15 15
mol:9cRA 0 0 -9999 0 -10000 0 0
RXRA 0.015 0.04 -9999 0 -0.52 3 3
RXRB 0.015 0.04 -9999 0 -0.52 3 3
CARM1 0.015 0.039 -9999 0 -0.36 5 5
NR2C2 0.016 0.02 -9999 0 -0.25 3 3
KLK2 0.021 0.095 -9999 0 -0.4 4 4
AR -0.04 0.13 -9999 0 -0.28 106 106
SENP1 0.018 0 -9999 0 -10000 0 0
HSP90AA1 0.013 0.045 -9999 0 -0.39 6 6
MDM2 0.009 0.044 -9999 0 -0.26 14 14
SRY 0.001 0.085 -9999 0 -0.43 18 18
GATA2 -0.007 0.093 -9999 0 -0.31 40 40
MYST2 0.011 0.047 -9999 0 -0.31 10 10
HOXB13 -0.074 0.13 -9999 0 -0.25 182 182
T-DHT/AR/RACK1/Src -0.002 0.11 -9999 0 -0.35 20 20
positive regulation of transcription -0.007 0.093 -9999 0 -0.31 40 40
DNAJA1 0.012 0.043 -9999 0 -0.46 4 4
proteasomal ubiquitin-dependent protein catabolic process 0.02 0.06 -9999 0 -0.31 16 16
NCOA1 0.016 0.063 -9999 0 -0.55 6 6
SPDEF -0.081 0.21 -9999 0 -0.52 98 98
T-DHT/AR/TIF2 0.009 0.08 -9999 0 -0.3 11 11
T-DHT/AR/Hsp90 -0.012 0.11 -9999 0 -0.36 22 22
GSK3B 0.018 0.003 -9999 0 -10000 0 0
NR2C1 0.01 0.062 -9999 0 -0.52 7 7
mol:T-DHT -0.002 0.095 -9999 0 -0.3 36 36
SIRT1 0.016 0.029 -9999 0 -0.34 3 3
ZMIZ2 0.016 0.002 -9999 0 -10000 0 0
POU2F1 0.014 0.038 -9999 0 -10000 0 0
T-DHT/AR/DAX-1 -0.022 0.12 -9999 0 -0.31 45 45
CREBBP 0.016 0.033 -9999 0 -0.52 2 2
SMARCE1 0.017 0.021 -9999 0 -0.26 3 3
Sphingosine 1-phosphate (S1P) pathway

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.017 0.023 -9999 0 -0.52 1 1
SPHK1 -0.027 0.14 -9999 0 -0.42 54 54
GNAI2 0.006 0.075 -9999 0 -0.48 12 12
mol:S1P -0.001 0.087 -9999 0 -0.3 35 35
GNAO1 0.016 0.024 -9999 0 -0.25 4 4
mol:Sphinganine-1-P -0.007 0.1 -9999 0 -0.38 33 33
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.015 0.075 -9999 0 -0.39 8 8
GNAI3 0.018 0 -9999 0 -10000 0 0
G12/G13 0.021 0.039 -9999 0 -0.37 4 4
S1PR3 0 0 -9999 0 -10000 0 0
S1PR2 0 0 -9999 0 -10000 0 0
EDG1 -0.019 0.12 -9999 0 -0.4 46 46
S1P1/S1P -0.012 0.11 -9999 0 -0.28 58 58
S1PR5 0 0 -9999 0 -10000 0 0
S1PR4 0 0 -9999 0 -10000 0 0
GNAI1 -0.017 0.12 -9999 0 -0.38 46 46
S1P/S1P5/G12 0.008 0.07 -9999 0 -0.23 35 35
S1P/S1P3/Gq -0.026 0.11 -9999 0 -0.28 66 66
S1P/S1P4/Gi 0.006 0.087 -9999 0 -0.32 20 20
GNAQ 0 0 -9999 0 -10000 0 0
GNAZ 0.001 0.088 -9999 0 -0.44 19 19
GNA14 -0.079 0.18 -9999 0 -0.35 140 140
GNA15 0.002 0.076 -9999 0 -0.34 23 23
GNA12 0.018 0 -9999 0 -10000 0 0
GNA13 0.011 0.055 -9999 0 -0.36 10 10
GNA11 0.014 0.047 -9999 0 -0.52 4 4
ABCC1 0.012 0.051 -9999 0 -0.41 7 7
S1P1 pathway

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0 0.1 -9999 0 -0.36 30 30
PDGFRB 0.01 0.067 -9999 0 -0.53 8 8
SPHK1 -0.054 0.19 -9999 0 -0.76 33 33
mol:S1P -0.049 0.17 -9999 0 -0.65 35 35
S1P1/S1P/Gi -0.002 0.15 -9999 0 -0.49 25 25
GNAO1 0.016 0.024 -9999 0 -0.26 4 4
PDGFB-D/PDGFRB/PLCgamma1 0.008 0.14 -9999 0 -0.49 21 21
PLCG1 0.004 0.14 -9999 0 -0.48 22 22
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB 0.01 0.067 -9999 0 -0.53 8 8
GNAI2 0.007 0.076 -9999 0 -0.48 12 12
GNAI3 0.018 0.003 -9999 0 -10000 0 0
GNAI1 -0.016 0.12 -9999 0 -0.38 46 46
mol:GDP 0 0 -9999 0 -10000 0 0
EDG1 -0.012 0.16 -9999 0 -0.52 38 38
S1P1/S1P -0.026 0.19 -9999 0 -0.51 56 56
negative regulation of cAMP metabolic process -0.001 0.14 -9999 0 -0.47 25 25
MAPK3 0.002 0.16 -9999 0 -0.53 22 22
calcium-dependent phospholipase C activity 0 0.003 -9999 0 -10000 0 0
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
RhoA/GDP 0.004 0.058 -9999 0 -0.38 12 12
KDR 0.006 0.076 -9999 0 -0.65 5 5
PLCB2 -0.015 0.17 -9999 0 -0.44 56 56
RAC1 0.018 0 -9999 0 -10000 0 0
RhoA/GTP -0.061 0.14 -9999 0 -0.42 59 59
receptor internalization -0.024 0.17 -9999 0 -0.47 57 57
PTGS2 -0.001 0.17 -9999 0 -0.72 14 14
Rac1/GTP -0.056 0.14 -9999 0 -0.42 56 56
RHOA 0.005 0.08 -9999 0 -0.52 12 12
VEGFA -0.006 0.085 -9999 0 -0.29 31 31
negative regulation of T cell proliferation -0.001 0.14 -9999 0 -0.47 25 25
GO:0007205 0 0 -9999 0 -10000 0 0
GNAZ 0.002 0.088 -9999 0 -0.44 19 19
MAPK1 0.002 0.16 -9999 0 -0.53 22 22
S1P1/S1P/PDGFB-D/PDGFRB -0.016 0.2 -9999 0 -0.49 57 57
ABCC1 0.012 0.051 -9999 0 -0.41 7 7
PLK1 signaling events

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion 0.001 0.05 0.26 17 -10000 0 17
BUB1B -0.017 0.12 -10000 0 -0.42 39 39
PLK1 0.002 0.041 -10000 0 -0.12 44 44
PLK1S1 0.002 0.019 -10000 0 -0.054 41 41
KIF2A 0.005 0.054 -10000 0 -0.28 10 10
regulation of mitotic centrosome separation 0.002 0.041 -10000 0 -0.12 44 44
GOLGA2 0.016 0.026 -10000 0 -0.39 2 2
Hec1/SPC24 -0.012 0.094 -10000 0 -0.31 39 39
WEE1 -0.003 0.093 -10000 0 -0.35 25 25
cytokinesis -0.025 0.16 -10000 0 -0.52 44 44
PP2A-alpha B56 -0.059 0.27 -10000 0 -0.76 62 62
AURKA -0.002 0.064 -10000 0 -0.28 23 23
PICH/PLK1 -0.023 0.18 -10000 0 -0.55 42 42
CENPE -0.011 0.096 -10000 0 -0.33 37 37
RhoA/GTP 0.004 0.058 -10000 0 -0.38 12 12
positive regulation of microtubule depolymerization 0.005 0.054 -10000 0 -0.28 10 10
PPP2CA 0.011 0.062 -10000 0 -0.52 7 7
FZR1 0.018 0 -10000 0 -10000 0 0
TPX2 -0.013 0.083 -10000 0 -0.29 40 40
PAK1 -0.023 0.13 -10000 0 -0.38 54 54
SPC24 0 0 -10000 0 -10000 0 0
FBXW11 0.015 0.035 -10000 0 -0.43 3 3
CLSPN 0.002 0.057 -10000 0 -0.33 12 12
GORASP1 0.017 0.023 -10000 0 -0.52 1 1
metaphase 0 0.002 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.002 0.019 -10000 0 -0.054 41 41
G2 phase of mitotic cell cycle -0.001 0.003 0.016 1 -0.013 21 22
STAG2 0.017 0.023 -10000 0 -0.52 1 1
GRASP65/GM130/RAB1/GTP 0.021 0.04 -10000 0 -0.74 1 1
spindle elongation 0.002 0.041 -10000 0 -0.12 44 44
ODF2 0.016 0.024 -10000 0 -0.53 1 1
BUB1 -0.1 0.28 -10000 0 -0.85 60 60
TPT1 0.009 0.019 -10000 0 -10000 0 0
CDC25C -0.016 0.11 -10000 0 -0.44 34 34
CDC25B 0.004 0.069 -10000 0 -0.3 23 23
SGOL1 -0.001 0.051 -10000 0 -0.26 17 17
RHOA 0.005 0.08 -10000 0 -0.52 12 12
CCNB1/CDK1 -0.013 0.15 -10000 0 -0.5 40 40
CDC14B 0.01 0.03 -10000 0 -0.38 3 3
CDC20 -0.02 0.12 -10000 0 -0.37 51 51
PLK1/PBIP1 -0.011 0.083 -10000 0 -0.29 37 37
mitosis 0.002 0.007 0.034 22 -10000 0 22
FBXO5 0.003 0.054 -10000 0 -0.19 20 20
CDC2 -0.012 0.12 -10000 0 -0.45 34 34
NDC80 -0.029 0.14 -10000 0 -0.41 57 57
metaphase plate congression 0.009 0.023 -10000 0 -10000 0 0
ERCC6L -0.026 0.19 -10000 0 -0.6 42 42
NLP/gamma Tubulin 0.005 0.022 -10000 0 -0.075 5 5
microtubule cytoskeleton organization 0.009 0.019 -10000 0 -10000 0 0
G2/M transition DNA damage checkpoint 0 0.002 0.011 5 -10000 0 5
PPP1R12A 0.015 0.031 -10000 0 -0.32 4 4
interphase 0 0.002 0.011 5 -10000 0 5
PLK1/PRC1-2 -0.017 0.14 -10000 0 -0.42 49 49
GRASP65/GM130/RAB1/GTP/PLK1 0.028 0.039 -10000 0 -0.22 3 3
RAB1A 0.017 0.023 -10000 0 -0.52 1 1
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.006 0.039 -10000 0 -0.15 18 18
mitotic prometaphase 0 0.001 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.018 0.058 -10000 0 -0.33 5 5
microtubule-based process -0.011 0.1 -10000 0 -0.34 40 40
Golgi organization 0.002 0.041 -10000 0 -0.12 44 44
Cohesin/SA2 0.009 0.036 -10000 0 -0.16 5 5
PPP1CB/MYPT1 0.023 0.026 -10000 0 -0.37 1 1
KIF20A -0.027 0.14 -10000 0 -0.46 49 49
APC/C/CDC20 -0.007 0.089 -10000 0 -0.34 28 28
PPP2R1A 0.017 0.012 -10000 0 -0.25 1 1
chromosome segregation -0.011 0.082 -10000 0 -0.28 37 37
PRC1 -0.019 0.13 -10000 0 -0.43 43 43
ECT2 -0.001 0.07 -10000 0 -0.31 18 18
C13orf34 0.006 0.037 -10000 0 -0.13 14 14
NUDC 0.009 0.023 -10000 0 -10000 0 0
regulation of attachment of spindle microtubules to kinetochore -0.016 0.12 -10000 0 -0.41 39 39
spindle assembly 0.005 0.031 -10000 0 -0.093 27 27
spindle stabilization 0.002 0.019 -10000 0 -0.053 41 41
APC/C/HCDH1 0.02 0.025 -10000 0 -0.32 3 3
MKLP2/PLK1 -0.011 0.1 -10000 0 -0.34 40 40
CCNB1 -0.016 0.13 -10000 0 -0.5 35 35
PPP1CB 0.016 0.02 -10000 0 -0.25 3 3
BTRC 0.008 0.054 -10000 0 -0.29 16 16
ROCK2 0.008 0.055 -10000 0 -0.34 7 7
TUBG1 0.008 0.02 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.046 0.14 -10000 0 -0.48 40 40
MLF1IP -0.018 0.1 -10000 0 -0.32 49 49
INCENP 0.001 0.081 -10000 0 -0.37 22 22
Atypical NF-kappaB pathway

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.019 0.052 -9999 0 -0.37 9 9
FBXW11 0.015 0.035 -9999 0 -0.43 3 3
NF kappa B1 p50/c-Rel 0.018 0.062 -9999 0 -0.31 15 15
NF kappa B1 p50/RelA/I kappa B alpha 0 0.11 -9999 0 -0.44 18 18
NFKBIA -0.024 0.12 -9999 0 -0.26 87 87
MAPK14 0.017 0.012 -9999 0 -0.25 1 1
NF kappa B1 p105/p50 0.026 0.038 -9999 0 -0.3 5 5
ARRB2 0.02 0.005 -9999 0 -10000 0 0
REL 0.001 0.087 -9999 0 -0.41 21 21
response to oxidative stress 0 0 -9999 0 -10000 0 0
BCL3/NF kappa B1 p50 0.022 0.054 -9999 0 -0.3 12 12
response to UV 0 0 -9999 0 -10000 0 0
NF kappa B1 p105/RelA 0.028 0.031 -9999 0 -0.3 3 3
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
NF kappa B1 p50 dimer 0.019 0.037 -9999 0 -0.37 3 3
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
NFKB1 0.02 0.037 -9999 0 -0.37 3 3
RELA 0.018 0 -9999 0 -10000 0 0
positive regulation of anti-apoptosis -0.014 0.1 -9999 0 -0.23 85 85
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.005 0.11 -9999 0 -0.44 17 17
SRC 0.015 0.035 -9999 0 -0.43 3 3
PI3K 0.005 0.082 -9999 0 -0.37 21 21
NF kappa B1 p50/RelA -0.014 0.1 -9999 0 -0.23 85 85
IKBKB 0.012 0.047 -9999 0 -0.31 10 10
beta TrCP1/SCF ubiquitin ligase complex 0.015 0.035 -9999 0 -0.43 3 3
SYK -0.023 0.14 -9999 0 -0.48 43 43
I kappa B alpha/PIK3R1 -0.027 0.13 -9999 0 -0.37 39 39
cell death 0.005 0.1 -9999 0 -0.42 17 17
NF kappa B1 p105/c-Rel 0.018 0.062 -9999 0 -0.31 15 15
LCK -0.074 0.18 -9999 0 -0.4 117 117
BCL3 0.008 0.071 -9999 0 -0.5 10 10
Angiopoietin receptor Tie2-mediated signaling

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.041 0.17 -10000 0 -0.9 12 12
NCK1/PAK1/Dok-R -0.032 0.083 -10000 0 -0.46 11 11
NCK1/Dok-R 0.029 0.18 -10000 0 -1.1 11 11
PIK3CA 0.015 0.029 -10000 0 -0.34 3 3
mol:beta2-estradiol -0.009 0.02 0.24 1 -10000 0 1
RELA 0.018 0 -10000 0 -10000 0 0
SHC1 0.017 0.024 -10000 0 -0.52 1 1
Rac/GDP 0.013 0 -10000 0 -10000 0 0
F2 0.006 0.021 0.26 1 -10000 0 1
TNIP2 0.012 0.052 -10000 0 -0.39 8 8
NF kappa B/RelA 0.052 0.15 -10000 0 -0.9 11 11
FN1 -0.048 0.17 -10000 0 -0.46 73 73
PLD2 0.037 0.16 -10000 0 -1 11 11
PTPN11 0.017 0.023 -10000 0 -0.52 1 1
GRB14 -0.16 0.21 -10000 0 -0.36 247 247
ELK1 0.046 0.15 -10000 0 -0.92 11 11
GRB7 -0.017 0.1 -10000 0 -0.29 59 59
PAK1 -0.022 0.13 -10000 0 -0.37 54 54
Tie2/Ang1/alpha5/beta1 Integrin 0.022 0.19 -10000 0 -1 11 11
CDKN1A 0.02 0.2 -10000 0 -0.76 28 28
ITGA5 0.015 0.035 -10000 0 -0.43 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R 0.026 0.18 -10000 0 -1 12 12
CRK 0.016 0.033 -10000 0 -0.52 2 2
mol:NO 0.05 0.14 -10000 0 -0.66 12 12
PLG 0.039 0.16 -10000 0 -1 11 11
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis 0.048 0.16 -10000 0 -0.87 11 11
GRB2 0.016 0.024 -10000 0 -0.25 4 4
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
ANGPT2 -0.018 0.16 -10000 0 -0.75 10 10
BMX 0.012 0.19 -10000 0 -1.2 11 11
ANGPT1 0.021 0.085 -10000 0 -1.2 1 1
tube development 0.026 0.17 -10000 0 -0.74 16 16
ANGPT4 0.017 0.026 -10000 0 -0.39 2 2
response to hypoxia 0.003 0.011 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.045 0.19 -10000 0 -1.1 11 11
alpha5/beta1 Integrin 0.022 0.041 -10000 0 -0.37 5 5
FGF2 -0.065 0.16 -10000 0 -0.34 122 122
STAT5A (dimer) 0.026 0.21 -10000 0 -0.79 25 25
mol:L-citrulline 0.05 0.14 -10000 0 -0.66 12 12
AGTR1 -0.15 0.21 -10000 0 -0.36 231 231
MAPK14 0.035 0.18 -10000 0 -1.1 11 11
Tie2/SHP2 0.027 0.16 -10000 0 -1.1 10 10
TEK 0.024 0.18 -10000 0 -1.2 10 10
RPS6KB1 0.04 0.16 -10000 0 -0.88 11 11
Angiotensin II/AT1 -0.099 0.15 -10000 0 -0.25 231 231
Tie2/Ang1/GRB2 0.04 0.16 -10000 0 -1 11 11
MAPK3 0.043 0.15 -10000 0 -0.92 11 11
MAPK1 0.042 0.15 -10000 0 -0.92 11 11
Tie2/Ang1/GRB7 0.025 0.17 -10000 0 -1 11 11
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
MAPK8 0.038 0.16 -10000 0 -1 11 11
PI3K 0.035 0.19 -10000 0 -1.1 11 11
FES 0.031 0.19 -10000 0 -1.1 12 12
Crk/Dok-R 0.031 0.18 -10000 0 -1 11 11
Tie2/Ang1/ABIN2 0.038 0.16 -10000 0 -1 11 11
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity 0.043 0.16 -10000 0 -0.8 12 12
STAT5A 0.011 0.056 -10000 0 -0.42 8 8
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 0.043 0.16 -10000 0 -0.88 11 11
Tie2/Ang2 0.015 0.22 -10000 0 -1 15 15
Tie2/Ang1 0.034 0.17 -10000 0 -1.1 11 11
FOXO1 0.043 0.17 -10000 0 -0.77 16 16
ELF1 0.017 0.073 -10000 0 -0.49 10 10
ELF2 0.037 0.16 -10000 0 -1 11 11
mol:Choline 0.038 0.16 -10000 0 -0.96 11 11
cell migration -0.023 0.051 -10000 0 -0.22 20 20
FYN 0.023 0.19 -10000 0 -0.85 16 16
DOK2 -0.021 0.13 -10000 0 -0.4 48 48
negative regulation of cell cycle 0.024 0.18 -10000 0 -0.67 28 28
ETS1 0.011 0.075 -10000 0 -0.3 24 24
PXN 0.05 0.14 -10000 0 -0.72 11 11
ITGB1 0.014 0.044 -10000 0 -0.41 5 5
NOS3 0.049 0.15 -10000 0 -0.75 12 12
RAC1 0.018 0 -10000 0 -10000 0 0
TNF 0.004 0.097 -10000 0 -0.35 32 32
MAPKKK cascade 0.038 0.16 -10000 0 -0.96 11 11
RASA1 0.004 0.078 -10000 0 -0.42 16 16
Tie2/Ang1/Shc 0.041 0.16 -10000 0 -1 11 11
NCK1 0.011 0.045 -10000 0 -0.28 12 12
vasculogenesis 0.051 0.13 -10000 0 -0.59 12 12
mol:Phosphatidic acid 0.038 0.16 -10000 0 -0.96 11 11
mol:Angiotensin II 0.002 0.002 -10000 0 -10000 0 0
mol:NADP 0.05 0.14 -10000 0 -0.66 12 12
Rac1/GTP -0.011 0.14 -10000 0 -0.82 11 11
MMP2 0.016 0.19 -10000 0 -1.1 11 11
Arf6 downstream pathway

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR -0.022 0.26 -10000 0 -1.1 30 30
regulation of axonogenesis -0.012 0.065 0.35 8 -10000 0 8
myoblast fusion 0.003 0.1 0.4 31 -10000 0 31
mol:GTP -0.002 0.062 -10000 0 -0.24 32 32
regulation of calcium-dependent cell-cell adhesion -0.018 0.082 0.25 39 -10000 0 39
ARF1/GTP 0.012 0.05 -10000 0 -0.32 3 3
mol:GM1 0 0.047 -10000 0 -0.25 4 4
mol:Choline 0.007 0.075 -10000 0 -0.34 16 16
lamellipodium assembly -0.001 0.11 -10000 0 -0.43 32 32
MAPK3 0.009 0.089 -10000 0 -0.33 33 33
ARF6/GTP/NME1/Tiam1 0.019 0.083 -10000 0 -0.25 39 39
ARF1 0.017 0.023 -10000 0 -0.52 1 1
ARF6/GDP -0.003 0.1 -10000 0 -0.4 31 31
ARF1/GDP 0.006 0.097 -10000 0 -0.36 33 33
ARF6 0.007 0.05 -10000 0 -0.62 2 2
RAB11A 0.016 0.029 -10000 0 -0.34 3 3
TIAM1 0.007 0.074 -10000 0 -0.44 13 13
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.009 0.09 -10000 0 -0.33 34 34
actin filament bundle formation 0.001 0.11 0.35 41 -10000 0 41
KALRN -0.022 0.078 -10000 0 -0.31 32 32
RAB11FIP3/RAB11A 0.019 0.05 -10000 0 -0.37 8 8
RhoA/GDP -0.001 0.11 -10000 0 -0.36 41 41
NME1 0.012 0.039 -10000 0 -0.25 11 11
Rac1/GDP 0.005 0.096 -10000 0 -0.36 32 32
substrate adhesion-dependent cell spreading -0.002 0.062 -10000 0 -0.24 32 32
cortical actin cytoskeleton organization -0.002 0.11 -10000 0 -0.43 32 32
RAC1 0.018 0 -10000 0 -10000 0 0
liver development -0.002 0.062 -10000 0 -0.24 32 32
ARF6/GTP -0.002 0.062 -10000 0 -0.24 32 32
RhoA/GTP 0.004 0.074 -10000 0 -0.36 14 14
mol:GDP -0.003 0.1 -10000 0 -0.4 32 32
ARF6/GTP/RAB11FIP3/RAB11A 0.019 0.058 -10000 0 -0.28 10 10
RHOA 0.005 0.08 -10000 0 -0.52 12 12
PLD1 0.001 0.078 -10000 0 -0.37 13 13
RAB11FIP3 0.01 0.063 -10000 0 -0.49 8 8
tube morphogenesis -0.001 0.11 -10000 0 -0.43 32 32
ruffle organization 0.012 0.065 -10000 0 -0.35 8 8
regulation of epithelial cell migration -0.002 0.062 -10000 0 -0.24 32 32
PLD2 0.01 0.06 -10000 0 -0.38 6 6
PIP5K1A 0.012 0.065 -10000 0 -0.35 8 8
mol:Phosphatidic acid 0.007 0.075 -10000 0 -0.34 16 16
Rac1/GTP -0.002 0.11 -10000 0 -0.44 32 32
mTOR signaling pathway

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0.015 0.035 -10000 0 -0.43 3 3
MKNK1 0.018 0 -10000 0 -10000 0 0
mol:PIP3 -0.037 0.11 0.25 10 -0.28 70 80
FRAP1 0.015 0.034 -10000 0 -10000 0 0
AKT1 -0.011 0.1 0.22 8 -0.25 71 79
INSR 0.015 0.037 -10000 0 -0.39 4 4
Insulin Receptor/Insulin 0.021 0.027 -10000 0 -0.31 3 3
mol:GTP 0.004 0.085 -10000 0 -0.24 28 28
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit -0.01 0.027 -10000 0 -0.18 1 1
TSC2 0.016 0.026 -10000 0 -0.39 2 2
RHEB/GDP -0.026 0.062 -10000 0 -0.27 15 15
TSC1 0.018 0 -10000 0 -10000 0 0
Insulin Receptor/IRS1 -0.022 0.12 -10000 0 -0.33 62 62
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA -0.011 0.031 -10000 0 -0.19 3 3
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.017 0.012 -10000 0 -0.25 1 1
RPS6KB1 0.01 0.065 0.19 8 -0.26 5 13
MAP3K5 -0.014 0.089 -10000 0 -0.36 30 30
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
apoptosis -0.014 0.089 -10000 0 -0.36 30 30
mol:LY294002 0 0.001 0.001 1 -0.001 67 68
EIF4B 0.016 0.062 0.18 8 -0.24 7 15
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.02 0.057 -10000 0 -0.24 3 3
eIF4E/eIF4G1/eIF4A1 -0.002 0.014 -10000 0 -10000 0 0
KIAA1303 0.015 0.031 -10000 0 -0.32 4 4
PI3K -0.02 0.12 -10000 0 -0.3 79 79
mTOR/RHEB/GTP/Raptor/GBL 0.032 0.054 0.18 8 -0.3 2 10
FKBP1A 0.017 0.017 -10000 0 -0.25 2 2
RHEB/GTP 0.009 0.076 -10000 0 -0.27 15 15
mol:Amino Acids 0 0.001 0.001 1 -0.001 67 68
FKBP12/Rapamycin 0.012 0.011 -10000 0 -0.17 2 2
PDPK1 -0.014 0.1 0.23 8 -0.26 70 78
EIF4E 0.018 0 -10000 0 -10000 0 0
ASK1/PP5C -0.011 0.15 -10000 0 -0.59 30 30
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.035 0.056 -10000 0 -0.56 4 4
TSC1/TSC2 0.009 0.095 0.22 8 -0.32 14 22
tumor necrosis factor receptor activity 0 0.001 0.001 67 -0.001 1 68
RPS6 0.015 0.037 -10000 0 -0.39 4 4
PPP5C 0.012 0.052 -10000 0 -0.39 8 8
EIF4G1 0.014 0.047 -10000 0 -0.52 4 4
IRS1 -0.034 0.12 -10000 0 -0.36 61 61
INS 0.017 0.023 -10000 0 -0.52 1 1
PTEN -0.002 0.1 -10000 0 -0.52 19 19
PDK2 -0.02 0.11 0.23 8 -0.27 76 84
EIF4EBP1 -0.012 0.16 -10000 0 -1.1 10 10
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
PPP2R5D 0.021 0.033 -10000 0 -10000 0 0
peptide biosynthetic process 0.025 0.03 -10000 0 -0.28 5 5
RHEB 0.016 0.026 -10000 0 -0.39 2 2
EIF4A1 0.018 0 -10000 0 -10000 0 0
mol:Rapamycin 0 0.001 0.003 15 -0.002 6 21
EEF2 0.025 0.031 -10000 0 -0.28 5 5
eIF4E/4E-BP1 -0.001 0.14 -10000 0 -1 10 10
Aurora A signaling

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.008 0.081 -9999 0 -0.29 23 23
BIRC5 -0.037 0.15 -9999 0 -0.41 67 67
NFKBIA 0.024 0.054 -9999 0 -0.33 3 3
CPEB1 0.003 0.071 -9999 0 -0.31 23 23
AKT1 0.022 0.057 -9999 0 -0.28 5 5
NDEL1 0.018 0 -9999 0 -10000 0 0
Aurora A/BRCA1 0.013 0.067 -9999 0 -0.28 16 16
NDEL1/TACC3 0.021 0.079 -9999 0 -0.36 16 16
GADD45A -0.011 0.11 -9999 0 -0.39 38 38
GSK3B 0.021 0.015 -9999 0 -10000 0 0
PAK1/Aurora A 0.002 0.087 -9999 0 -0.3 25 25
MDM2 0.011 0.044 -9999 0 -0.25 14 14
JUB -0.027 0.15 -9999 0 -0.49 47 47
TPX2 -0.009 0.11 -9999 0 -0.37 40 40
TP53 0.004 0.089 -9999 0 -0.29 37 37
DLG7 -0.005 0.11 -9999 0 -0.35 44 44
AURKAIP1 0.016 0.029 -9999 0 -0.34 3 3
ARHGEF7 0.016 0.02 -9999 0 -0.25 3 3
G2 phase of mitotic cell cycle 0 0 -9999 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.022 0.083 -9999 0 -0.38 16 16
G2/M transition of mitotic cell cycle 0.013 0.066 -9999 0 -0.28 16 16
AURKA 0.021 0.058 -9999 0 -0.21 21 21
AURKB -0.007 0.078 -9999 0 -0.32 21 21
CDC25B 0.011 0.069 -9999 0 -0.31 8 8
G2/M transition checkpoint -0.002 0.088 -9999 0 -0.27 42 42
mRNA polyadenylation 0.015 0.054 -9999 0 -0.26 6 6
Aurora A/CPEB 0.016 0.055 -9999 0 -0.26 6 6
Aurora A/TACC1/TRAP/chTOG 0.016 0.093 -9999 0 -0.26 37 37
BRCA1 0 0.094 -9999 0 -0.48 19 19
centrosome duplication 0.002 0.087 -9999 0 -0.3 25 25
regulation of centrosome cycle 0.02 0.078 -9999 0 -0.35 16 16
spindle assembly 0.015 0.092 -9999 0 -0.26 37 37
TDRD7 0.004 0.084 -9999 0 -0.5 14 14
Aurora A/RasGAP/Survivin -0.001 0.12 -9999 0 -0.3 57 57
CENPA -0.016 0.12 -9999 0 -0.36 46 46
Aurora A/PP2A 0.025 0.047 -9999 0 -0.21 1 1
meiosis 0 0 -9999 0 -10000 0 0
protein catabolic process 0.008 0.088 -9999 0 -0.33 21 21
negative regulation of DNA binding 0.004 0.089 -9999 0 -0.29 37 37
prophase 0 0 -9999 0 -10000 0 0
GIT1/beta-PIX 0.023 0.028 -9999 0 -0.37 1 1
RASA1 0.004 0.078 -9999 0 -0.42 16 16
Ajuba/Aurora A -0.002 0.089 -9999 0 -0.27 42 42
mitotic prometaphase -0.001 0.007 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.021 0.058 -9999 0 -0.21 21 21
TACC1 -0.022 0.13 -9999 0 -0.41 49 49
TACC3 -0.006 0.11 -9999 0 -0.47 26 26
Aurora A/Antizyme1 0.034 0.044 -9999 0 -0.27 1 1
Aurora A/RasGAP 0.018 0.066 -9999 0 -0.3 11 11
OAZ1 0.018 0 -9999 0 -10000 0 0
RAN 0.017 0.012 -9999 0 -0.25 1 1
mitosis 0 0 -9999 0 -10000 0 0
PRKACA 0.021 0.015 -9999 0 -10000 0 0
GIT1 0.014 0.035 -9999 0 -0.3 6 6
GIT1/beta-PIX/PAK1 0.009 0.084 -9999 0 -0.32 24 24
Importin alpha/Importin beta/TPX2 -0.009 0.11 -9999 0 -0.37 40 40
PPP2R5D 0.016 0.02 -9999 0 -0.25 3 3
Aurora A/TPX2 0.006 0.1 -9999 0 -0.4 26 26
PAK1 -0.022 0.13 -9999 0 -0.37 54 54
CKAP5 0.017 0.017 -9999 0 -0.25 2 2
HIF-2-alpha transcription factor network

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 -0.054 0.27 -10000 0 -1.2 28 28
oxygen homeostasis 0.007 0.013 -10000 0 -10000 0 0
TCEB2 0.018 0 -10000 0 -10000 0 0
TCEB1 0.014 0.035 -10000 0 -0.3 6 6
VHL/Elongin B/Elongin C/HIF2A 0.035 0.13 -10000 0 -0.38 21 21
EPO 0.051 0.23 -10000 0 -0.58 28 28
FIH (dimer) 0.024 0.027 -10000 0 -0.52 1 1
APEX1 0.024 0.019 -10000 0 -0.26 1 1
SERPINE1 0.051 0.26 -10000 0 -0.7 31 31
FLT1 -0.023 0.2 -10000 0 -1.1 15 15
ADORA2A 0.041 0.25 -10000 0 -0.66 33 33
germ cell development 0.066 0.23 -10000 0 -0.62 26 26
SLC11A2 0.064 0.24 -10000 0 -0.66 27 27
BHLHE40 0.056 0.23 -10000 0 -0.62 31 31
HIF1AN 0.024 0.027 -10000 0 -0.53 1 1
HIF2A/ARNT/SIRT1 0.039 0.17 -10000 0 -0.43 30 30
ETS1 0.018 0.075 -10000 0 -0.3 24 24
CITED2 -0.013 0.15 -10000 0 -1.1 9 9
KDR -0.01 0.15 -10000 0 -1.1 9 9
PGK1 0.066 0.23 -10000 0 -0.65 25 25
SIRT1 0.015 0.029 -10000 0 -0.35 3 3
response to hypoxia -0.001 0.003 -10000 0 -10000 0 0
HIF2A/ARNT 0.082 0.27 -10000 0 -0.72 31 31
EPAS1 0.018 0.15 -10000 0 -0.38 35 35
SP1 0.023 0.027 -10000 0 -0.52 1 1
ABCG2 0.058 0.25 -10000 0 -0.69 30 30
EFNA1 0.056 0.25 -10000 0 -0.63 34 34
FXN 0.057 0.23 -10000 0 -0.65 25 25
POU5F1 0.066 0.23 -10000 0 -0.65 26 26
neuron apoptosis -0.081 0.27 0.7 31 -10000 0 31
EP300 0.014 0.047 -10000 0 -0.52 4 4
EGLN3 -0.066 0.18 -10000 0 -0.39 116 116
EGLN2 0.018 0.054 -10000 0 -0.36 9 9
EGLN1 0.008 0.084 -10000 0 -0.35 24 24
VHL/Elongin B/Elongin C 0.032 0.027 -10000 0 -0.3 1 1
VHL 0.015 0.029 -10000 0 -0.25 6 6
ARNT 0.025 0.014 -10000 0 -10000 0 0
SLC2A1 0.051 0.24 -10000 0 -0.65 29 29
TWIST1 0.035 0.27 -10000 0 -0.7 43 43
ELK1 0.022 0.038 -10000 0 -0.38 4 4
HIF2A/ARNT/Cbp/p300 0.052 0.17 -10000 0 -0.44 27 27
VEGFA 0.058 0.24 -10000 0 -0.65 28 28
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
PDGFR-beta signaling pathway

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate -0.012 0.14 -9999 0 -0.44 32 32
PDGFB-D/PDGFRB/SLAP 0.01 0.074 -9999 0 -0.38 17 17
PDGFB-D/PDGFRB/APS/CBL 0.018 0.042 -9999 0 -0.32 8 8
AKT1 -0.021 0.14 -9999 0 -0.39 34 34
mol:PI-4-5-P2 0 0.001 -9999 0 -10000 0 0
mol:Sphingosine-1-phosphate -0.006 0.13 -9999 0 -0.49 22 22
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
FGR -0.008 0.065 -9999 0 -0.39 10 10
mol:Ca2+ 0.004 0.11 -9999 0 -0.62 11 11
MYC -0.029 0.22 -9999 0 -0.74 42 42
SHC1 0.017 0.023 -9999 0 -0.52 1 1
HRAS/GDP 0.02 0.069 -9999 0 -0.25 25 25
LRP1/PDGFRB/PDGFB 0.024 0.064 -9999 0 -0.35 13 13
GRB10 -0.003 0.097 -9999 0 -0.43 24 24
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
GO:0007205 0.003 0.11 -9999 0 -0.63 11 11
PTEN -0.002 0.1 -9999 0 -0.52 19 19
GRB2 0.016 0.024 -9999 0 -0.25 4 4
GRB7 -0.017 0.1 -9999 0 -0.29 59 59
PDGFB-D/PDGFRB/SHP2 0.019 0.052 -9999 0 -0.37 9 9
PDGFB-D/PDGFRB/GRB10 0.005 0.086 -9999 0 -0.37 24 24
cell cycle arrest 0.01 0.074 -9999 0 -0.37 17 17
HRAS 0.012 0.051 -9999 0 -0.41 7 7
HIF1A -0.035 0.14 -9999 0 -0.34 49 49
GAB1 -0.011 0.13 -9999 0 -0.61 15 15
mol:GTP 0 0 -9999 0 -10000 0 0
DNM2 -0.008 0.13 -9999 0 -0.59 14 14
PDGFB-D/PDGFRB 0.019 0.067 -9999 0 -0.35 12 12
mol:GDP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.016 0.062 -9999 0 -0.37 13 13
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB -0.017 0.15 -9999 0 -0.47 33 33
positive regulation of MAPKKK cascade 0.019 0.052 -9999 0 -0.37 9 9
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
mol:IP3 0.003 0.11 -9999 0 -0.64 11 11
E5 0 0.002 -9999 0 -10000 0 0
CSK 0.015 0.031 -9999 0 -0.32 4 4
PDGFB-D/PDGFRB/GRB7 -0.004 0.085 -9999 0 -0.37 16 16
SHB 0.008 0.067 -9999 0 -0.41 12 12
BLK -0.024 0.091 -9999 0 -0.45 18 18
PTPN2 0.015 0.024 -9999 0 -0.26 4 4
PDGFB-D/PDGFRB/SNX15 0.019 0.05 -9999 0 -0.37 8 8
BCAR1 0.017 0.012 -9999 0 -0.25 1 1
VAV2 -0.011 0.14 -9999 0 -0.53 21 21
CBL 0.017 0.012 -9999 0 -0.25 1 1
PDGFB-D/PDGFRB/DEP1 0.015 0.063 -9999 0 -0.37 13 13
LCK -0.082 0.2 -9999 0 -0.57 68 68
PDGFRB 0.009 0.067 -9999 0 -0.53 8 8
ACP1 0.013 0.052 -9999 0 -0.52 5 5
HCK -0.029 0.14 -9999 0 -0.55 28 28
ABL1 -0.005 0.11 -9999 0 -0.49 17 17
PDGFB-D/PDGFRB/CBL -0.01 0.14 -9999 0 -0.64 16 16
PTPN1 0.001 0.07 -9999 0 -0.28 28 28
SNX15 0.017 0.012 -9999 0 -0.25 1 1
STAT3 0.015 0.04 -9999 0 -0.52 3 3
STAT1 -0.02 0.12 -9999 0 -0.33 58 58
cell proliferation -0.022 0.2 -9999 0 -0.64 43 43
SLA 0.004 0.078 -9999 0 -0.39 18 18
actin cytoskeleton reorganization 0.032 0.07 -9999 0 -0.37 7 7
SRC -0.009 0.083 -9999 0 -0.46 12 12
PI3K -0.066 0.12 -9999 0 -0.44 31 31
PDGFB-D/PDGFRB/GRB7/SHC 0.01 0.074 -9999 0 -0.31 17 17
SH2B2 0 0 -9999 0 -10000 0 0
PLCgamma1/SPHK1 -0.007 0.14 -9999 0 -0.51 22 22
LYN -0.007 0.066 -9999 0 -0.38 11 11
LRP1 0.017 0.023 -9999 0 -0.52 1 1
SOS1 0.017 0.023 -9999 0 -0.52 1 1
STAT5B 0.016 0.026 -9999 0 -0.39 2 2
STAT5A 0.011 0.056 -9999 0 -0.42 8 8
NCK1-2/p130 Cas 0.033 0.062 -9999 0 -0.35 5 5
SPHK1 -0.027 0.14 -9999 0 -0.42 54 54
EDG1 -0.019 0.12 -9999 0 -0.4 46 46
mol:DAG 0.003 0.11 -9999 0 -0.64 11 11
PLCG1 0.003 0.11 -9999 0 -0.66 11 11
NHERF/PDGFRB -0.038 0.15 -9999 0 -0.35 91 91
YES1 -0.016 0.096 -9999 0 -0.47 18 18
cell migration -0.038 0.15 -9999 0 -0.35 91 91
SHC/Grb2/SOS1 0.036 0.06 -9999 0 -0.3 7 7
SLC9A3R2 -0.032 0.15 -9999 0 -0.49 52 52
SLC9A3R1 -0.043 0.16 -9999 0 -0.44 70 70
NHERF1-2/PDGFRB/PTEN -0.033 0.16 -9999 0 -0.32 103 103
FYN -0.017 0.14 -9999 0 -0.77 12 12
DOK1 0.013 0.074 -9999 0 -0.3 23 23
HRAS/GTP 0.009 0.036 -9999 0 -0.29 7 7
PDGFB 0.009 0.064 -9999 0 -0.39 12 12
RAC1 -0.011 0.16 -9999 0 -0.49 40 40
PRKCD 0.019 0.065 -9999 0 -0.32 14 14
FER 0.02 0.06 -9999 0 -0.3 13 13
MAPKKK cascade -0.006 0.05 -9999 0 -0.34 4 4
RASA1 0.013 0.072 -9999 0 -0.29 22 22
NCK1 0.011 0.045 -9999 0 -0.28 12 12
NCK2 0.015 0.026 -9999 0 -0.25 5 5
p62DOK/Csk 0.023 0.071 -9999 0 -0.27 23 23
PDGFB-D/PDGFRB/SHB 0.013 0.071 -9999 0 -0.4 14 14
chemotaxis -0.004 0.11 -9999 0 -0.47 17 17
STAT1-3-5/STAT1-3-5 -0.021 0.071 -9999 0 -0.4 6 6
Bovine Papilomavirus E5/PDGFRB 0.006 0.049 -9999 0 -0.39 8 8
PTPRJ 0.012 0.055 -9999 0 -0.44 7 7
Signaling events mediated by PRL

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 -0.018 0.099 -10000 0 -0.28 64 64
mol:Halofuginone 0.004 0.012 -10000 0 -10000 0 0
ITGA1 0 0.096 -10000 0 -0.51 18 18
CDKN1A -0.017 0.12 -10000 0 -0.47 24 24
PRL-3/alpha Tubulin 0.024 0.026 -10000 0 -0.37 1 1
mol:Ca2+ -0.076 0.13 0.38 1 -0.26 156 157
AGT -0.095 0.19 -10000 0 -0.36 158 158
CCNA2 -0.044 0.13 -10000 0 -0.68 4 4
TUBA1B 0.018 0 -10000 0 -10000 0 0
EGR1 -0.06 0.15 -10000 0 -0.37 82 82
CDK2/Cyclin E1 -0.016 0.12 -10000 0 -0.44 27 27
MAPK3 0.022 0.032 -10000 0 -0.37 2 2
PRL-2 /Rab GGTase beta 0.017 0.053 -10000 0 -0.37 8 8
MAPK1 0.021 0.035 -10000 0 -0.37 3 3
PTP4A1 -0.031 0.12 -10000 0 -0.66 4 4
PTP4A3 0.014 0.037 -10000 0 -0.29 7 7
PTP4A2 0.006 0.072 -10000 0 -0.4 15 15
ITGB1 0.02 0.041 -10000 0 -0.37 4 4
SRC 0.015 0.035 -10000 0 -0.43 3 3
RAC1 0.004 0.066 -10000 0 -0.57 2 2
Rab GGTase beta/Rab GGTase alpha 0.026 0.011 -10000 0 -10000 0 0
PRL-1/ATF-5 -0.022 0.12 -10000 0 -0.61 4 4
RABGGTA 0.018 0 -10000 0 -10000 0 0
BCAR1 0.002 0.023 0.38 1 -10000 0 1
RHOC 0.001 0.075 -10000 0 -0.5 5 5
RHOA -0.006 0.089 -10000 0 -0.42 14 14
cell motility 0.002 0.075 -10000 0 -0.49 3 3
PRL-1/alpha Tubulin -0.02 0.12 -10000 0 -0.61 4 4
PRL-3/alpha1 Integrin 0.011 0.077 -10000 0 -0.39 17 17
ROCK1 0.002 0.075 -10000 0 -0.5 3 3
RABGGTB 0.017 0.017 -10000 0 -0.25 2 2
CDK2 0.012 0.047 -10000 0 -0.31 10 10
mitosis -0.031 0.12 -10000 0 -0.65 4 4
ATF5 0.013 0.04 -10000 0 -0.28 9 9
EPHB forward signaling

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0.011 0.056 -10000 0 -0.3 12 12
cell-cell adhesion 0.038 0.084 0.37 18 -10000 0 18
Ephrin B/EPHB2/RasGAP 0.023 0.087 -10000 0 -0.28 32 32
ITSN1 0.015 0.035 -10000 0 -0.43 3 3
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
SHC1 0.017 0.023 -10000 0 -0.52 1 1
Ephrin B1/EPHB3 0.006 0.072 -10000 0 -0.32 21 21
Ephrin B1/EPHB1 -0.003 0.07 -10000 0 -0.3 13 13
HRAS/GDP -0.034 0.081 -10000 0 -0.3 28 28
Ephrin B/EPHB1/GRB7 -0.003 0.097 -10000 0 -0.27 34 34
Endophilin/SYNJ1 0.018 0.065 -10000 0 -0.23 25 25
KRAS 0.009 0.065 -10000 0 -0.44 10 10
Ephrin B/EPHB1/Src 0.013 0.089 -10000 0 -0.28 26 26
endothelial cell migration -0.006 0.11 -10000 0 -0.28 59 59
GRB2 0.016 0.024 -10000 0 -0.25 4 4
GRB7 -0.017 0.1 -10000 0 -0.29 59 59
PAK1 0.002 0.093 -10000 0 -0.35 8 8
HRAS 0.012 0.051 -10000 0 -0.41 7 7
RRAS 0.015 0.075 -10000 0 -0.25 32 32
DNM1 0.013 0.047 -10000 0 -0.37 7 7
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK 0.005 0.079 -10000 0 -0.26 27 27
lamellipodium assembly -0.038 0.084 -10000 0 -0.37 18 18
Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.016 0.077 -10000 0 -0.47 5 5
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
EPHB2 0.007 0.061 -10000 0 -0.32 16 16
EPHB3 -0.005 0.1 -10000 0 -0.45 26 26
EPHB1 -0.022 0.1 -10000 0 -0.28 72 72
EPHB4 -0.013 0.12 -10000 0 -0.43 36 36
mol:GDP 0 0.1 -10000 0 -0.33 25 25
Ephrin B/EPHB2 0.019 0.07 -10000 0 -0.25 26 26
Ephrin B/EPHB3 0.012 0.086 -10000 0 -0.27 37 37
JNK cascade 0.006 0.082 -10000 0 -0.28 23 23
Ephrin B/EPHB1 0.005 0.084 -10000 0 -0.26 33 33
RAP1/GDP 0.013 0.099 -10000 0 -0.33 15 15
EFNB2 -0.008 0.11 -10000 0 -0.4 33 33
EFNB3 0.018 0 -10000 0 -10000 0 0
EFNB1 0.01 0.051 -10000 0 -0.3 13 13
Ephrin B2/EPHB1-2 -0.007 0.089 -10000 0 -0.28 34 34
RAP1B 0.013 0.044 -10000 0 -0.32 8 8
RAP1A 0.012 0.057 -10000 0 -0.52 6 6
CDC42/GTP -0.031 0.076 -10000 0 -0.39 11 11
Rap1/GTP -0.03 0.079 -10000 0 -0.4 14 14
axon guidance 0.011 0.056 -10000 0 -0.3 12 12
MAPK3 0.027 0.07 -10000 0 -0.42 5 5
MAPK1 0.027 0.071 -10000 0 -0.39 6 6
Rac1/GDP 0.01 0.095 -10000 0 -0.31 23 23
actin cytoskeleton reorganization -0.035 0.074 -10000 0 -0.31 18 18
CDC42/GDP 0.01 0.095 -10000 0 -0.31 23 23
PI3K -0.003 0.11 -10000 0 -0.28 59 59
EFNA5 0.006 0.068 -10000 0 -0.35 17 17
Ephrin B2/EPHB4 -0.01 0.1 -10000 0 -0.33 40 40
Ephrin B/EPHB2/Intersectin/N-WASP 0.02 0.069 -10000 0 -0.23 34 34
CDC42 0.018 0 -10000 0 -10000 0 0
RAS family/GTP -0.035 0.077 -10000 0 -0.34 17 17
PTK2 0.006 0.034 -10000 0 -0.34 3 3
MAP4K4 0.006 0.083 -10000 0 -0.28 23 23
SRC 0.015 0.035 -10000 0 -0.43 3 3
KALRN 0.006 0.057 -10000 0 -0.27 21 21
Intersectin/N-WASP 0.019 0.054 -10000 0 -0.37 10 10
neuron projection morphogenesis 0.009 0.11 -10000 0 -0.34 22 22
MAP2K1 0.022 0.073 -10000 0 -0.44 5 5
WASL 0.01 0.066 -10000 0 -0.52 8 8
Ephrin B1/EPHB1-2/NCK1 0.011 0.081 -10000 0 -0.27 26 26
cell migration 0.026 0.077 -10000 0 -0.45 5 5
NRAS 0.005 0.076 -10000 0 -0.4 16 16
SYNJ1 0.019 0.066 -10000 0 -0.24 25 25
PXN 0.018 0 -10000 0 -10000 0 0
TF 0.019 0.066 -10000 0 -0.32 1 1
HRAS/GTP 0.004 0.092 -10000 0 -0.38 12 12
Ephrin B1/EPHB1-2 0.004 0.074 -10000 0 -0.27 22 22
cell adhesion mediated by integrin 0.012 0.062 0.26 22 -10000 0 22
RAC1 0.018 0 -10000 0 -10000 0 0
mol:GTP 0.008 0.097 -10000 0 -0.41 11 11
RAC1-CDC42/GTP -0.034 0.08 -10000 0 -0.35 18 18
RASA1 0.004 0.078 -10000 0 -0.42 16 16
RAC1-CDC42/GDP 0.017 0.093 -10000 0 -0.34 9 9
ruffle organization 0.008 0.11 -10000 0 -0.38 17 17
NCK1 0.011 0.045 -10000 0 -0.28 12 12
receptor internalization 0.022 0.067 -10000 0 -0.32 2 2
Ephrin B/EPHB2/KALRN 0.024 0.078 -10000 0 -0.27 24 24
ROCK1 0.012 0.064 -10000 0 -0.28 21 21
RAS family/GDP -0.035 0.077 -10000 0 -0.33 17 17
Rac1/GTP -0.039 0.089 -10000 0 -0.39 18 18
Ephrin B/EPHB1/Src/Paxillin 0.013 0.077 -10000 0 -0.49 4 4
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A 0.015 0.029 -9999 0 -0.25 6 6
oxygen homeostasis 0 0 -9999 0 -10000 0 0
TCEB2 0.018 0 -9999 0 -10000 0 0
TCEB1 0.014 0.035 -9999 0 -0.3 6 6
HIF1A/p53 -0.02 0.11 -9999 0 -0.32 39 39
HIF1A -0.011 0.087 -9999 0 -0.32 20 20
COPS5 0.01 0.056 -9999 0 -0.35 11 11
VHL/Elongin B/Elongin C/RBX1/CUL2 0.049 0.025 -9999 0 -0.24 1 1
FIH (dimer) 0.017 0.023 -9999 0 -0.52 1 1
CDKN2A -0.053 0.15 -9999 0 -0.33 108 108
ARNT/IPAS 0.024 0.02 -9999 0 -10000 0 0
HIF1AN 0.017 0.023 -9999 0 -0.52 1 1
GNB2L1 0.015 0.04 -9999 0 -0.52 3 3
HIF1A/ARNT 0 0.084 -9999 0 -0.3 20 20
CUL2 0.017 0.017 -9999 0 -0.25 2 2
OS9 0.014 0.04 -9999 0 -0.34 6 6
RACK1/Elongin B/Elongin C 0.032 0.033 -9999 0 -0.3 4 4
response to hypoxia 0 0 -9999 0 -10000 0 0
HIF1A/Hsp90 -0.002 0.089 -9999 0 -0.32 20 20
PHD1-3/OS9 -0.021 0.12 -9999 0 -0.29 76 76
HIF1A/RACK1/Elongin B/Elongin C 0.013 0.083 -9999 0 -0.27 18 18
VHL 0.015 0.029 -9999 0 -0.25 6 6
HSP90AA1 0.013 0.045 -9999 0 -0.39 6 6
HIF1A/JAB1 -0.004 0.087 -9999 0 -0.29 22 22
EGLN3 -0.074 0.18 -9999 0 -0.4 116 116
EGLN2 0.011 0.053 -9999 0 -0.37 9 9
EGLN1 0.001 0.082 -9999 0 -0.35 24 24
TP53 -0.023 0.14 -9999 0 -0.48 43 43
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.034 0.033 -9999 0 -0.5 1 1
ARNT 0.018 0 -9999 0 -10000 0 0
ARD1A 0.016 0.02 -9999 0 -0.25 3 3
RBX1 0.018 0 -9999 0 -10000 0 0
HIF1A/p19ARF -0.032 0.11 -9999 0 -0.32 36 36
p38 MAPK signaling pathway

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.001 0.073 -9999 0 -0.26 34 34
TRAF2/ASK1 -0.002 0.085 -9999 0 -0.31 33 33
ATM 0.017 0.012 -9999 0 -0.25 1 1
MAP2K3 -0.011 0.12 -9999 0 -0.38 37 37
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 -0.016 0.12 -9999 0 -0.33 40 40
hyperosmotic response 0 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
GADD45G 0.003 0.083 -9999 0 -0.45 16 16
TXN 0.009 0.007 -9999 0 -10000 0 0
CALM1 0.018 0 -9999 0 -10000 0 0
GADD45A -0.011 0.11 -9999 0 -0.39 38 38
GADD45B -0.002 0.097 -9999 0 -0.44 23 23
MAP3K1 -0.03 0.14 -9999 0 -0.42 58 58
MAP3K6 0.015 0.035 -9999 0 -0.43 3 3
MAP3K7 0.016 0.02 -9999 0 -0.25 3 3
MAP3K4 0.018 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
ASK1/ASK2 -0.004 0.099 -9999 0 -0.37 33 33
TAK1/TAB family 0.01 0.038 -9999 0 -0.42 4 4
RAC1/OSM/MEKK3 0.034 0.006 -9999 0 -10000 0 0
TRAF2 0.014 0.042 -9999 0 -0.45 4 4
RAC1/OSM/MEKK3/MKK3 -0.029 0.079 -9999 0 -0.28 37 37
TRAF6 0.017 0.033 -9999 0 -0.32 5 5
RAC1 0.018 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
CAMK2B -0.078 0.18 -9999 0 -0.36 133 133
CCM2 0.018 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB -0.034 0.11 -9999 0 -0.31 55 55
MAPK11 0.018 0 -9999 0 -10000 0 0
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 -0.04 0.12 -9999 0 -0.29 87 87
OSM/MEKK3 0.026 0.008 -9999 0 -10000 0 0
TAOK1 0.012 0.044 -9999 0 -0.32 7 7
TAOK2 0.02 0.005 -9999 0 -10000 0 0
TAOK3 0.019 0.016 -9999 0 -0.32 1 1
MAP3K7IP1 0.018 0 -9999 0 -10000 0 0
MAPK14 0.017 0.012 -9999 0 -0.25 1 1
MAP3K7IP2 0.014 0.047 -9999 0 -0.52 4 4
MAP3K5 -0.022 0.13 -9999 0 -0.42 47 47
MAP3K10 -0.001 0.097 -9999 0 -0.48 20 20
MAP3K3 0.017 0.012 -9999 0 -0.25 1 1
TRX/ASK1 -0.003 0.079 -9999 0 -0.31 30 30
GADD45/MTK1/MTK1 0.009 0.097 -9999 0 -0.29 42 42
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.018 0 -9999 0 -10000 0 0
VLDLR -0.061 0.17 -9999 0 -0.4 100 100
LRPAP1 0.016 0.026 -9999 0 -0.39 2 2
NUDC 0.018 0 -9999 0 -10000 0 0
RELN/LRP8 -0.015 0.1 -9999 0 -0.31 43 43
CaM/Ca2+ 0.013 0 -9999 0 -10000 0 0
KATNA1 0.015 0.033 -9999 0 -0.31 5 5
GO:0030286 0 0 -9999 0 -10000 0 0
ABL1 -0.008 0.093 -9999 0 -0.28 43 43
IQGAP1/CaM 0.026 0 -9999 0 -10000 0 0
DAB1 0.018 0 -9999 0 -10000 0 0
IQGAP1 0.018 0 -9999 0 -10000 0 0
PLA2G7 -0.092 0.2 -9999 0 -0.41 137 137
CALM1 0.018 0 -9999 0 -10000 0 0
DYNLT1 0.018 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
LRPAP1/LRP8 -0.027 0.11 -9999 0 -0.37 37 37
UniProt:Q4QZ09 0 0 -9999 0 -10000 0 0
CLIP1 0.015 0.037 -9999 0 -0.39 4 4
CDK5R1 0.014 0.031 -9999 0 -0.25 7 7
LIS1/Poliovirus Protein 3A 0.018 0.02 -9999 0 -0.31 2 2
CDK5R2 0.017 0.017 -9999 0 -0.25 2 2
mol:PP1 0 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1 -0.017 0.11 -9999 0 -0.31 59 59
YWHAE 0.016 0.029 -9999 0 -0.34 3 3
NDEL1/14-3-3 E 0.024 0.079 -9999 0 -0.29 4 4
MAP1B -0.015 0.075 -9999 0 -0.29 34 34
RAC1 0.024 0.01 -9999 0 -10000 0 0
p35/CDK5 0.007 0.085 -9999 0 -0.33 3 3
RELN 0.01 0.059 -9999 0 -0.38 11 11
PAFAH/LIS1 -0.036 0.12 -9999 0 -0.3 80 80
LIS1/CLIP170 0.029 0.031 -9999 0 -0.3 4 4
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.016 0.043 -9999 0 -0.29 1 1
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 0.002 0.096 -9999 0 -0.45 3 3
GO:0005869 0 0 -9999 0 -10000 0 0
NDEL1 0.016 0.08 -9999 0 -0.31 3 3
LIS1/IQGAP1 0.031 0.021 -9999 0 -0.3 2 2
RHOA 0.014 0.067 -9999 0 -0.42 12 12
PAFAH1B1 0.024 0.024 -9999 0 -0.37 2 2
PAFAH1B3 0.009 0.067 -9999 0 -0.49 9 9
PAFAH1B2 0.017 0.012 -9999 0 -0.25 1 1
MAP1B/LIS1/Dynein heavy chain 0.013 0.055 -9999 0 -0.31 2 2
NDEL1/Katanin 60/Dynein heavy chain 0.031 0.078 -9999 0 -10000 0 0
LRP8 -0.057 0.16 -9999 0 -0.34 110 110
NDEL1/Katanin 60 0.024 0.079 -9999 0 -0.29 3 3
P39/CDK5 0.008 0.084 -9999 0 -0.33 3 3
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.031 0.021 -9999 0 -0.3 2 2
CDK5 -0.001 0.087 -9999 0 -0.25 43 43
PPP2R5D 0.016 0.02 -9999 0 -0.25 3 3
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.025 0.026 -9999 0 -0.26 4 4
CSNK2A1 0.017 0.023 -9999 0 -0.52 1 1
RELN/VLDLR/DAB1/LIS1 0.003 0.1 -9999 0 -0.25 59 59
RELN/VLDLR -0.045 0.14 -9999 0 -0.28 113 113
CDC42 0.024 0.01 -9999 0 -10000 0 0
Hedgehog signaling events mediated by Gli proteins

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.016 0.023 -9999 0 -0.52 1 1
HDAC2 0.009 0.053 -9999 0 -0.29 15 15
GNB1/GNG2 -0.008 0.11 -9999 0 -0.31 55 55
forebrain development 0.005 0.14 -9999 0 -0.54 18 18
GNAO1 0.017 0.024 -9999 0 -0.25 4 4
SMO/beta Arrestin2 -0.018 0.12 -9999 0 -0.37 49 49
SMO -0.047 0.16 -9999 0 -0.41 82 82
ARRB2 0.019 0.001 -9999 0 -10000 0 0
GLI3/SPOP 0.011 0.13 -9999 0 -0.43 21 21
mol:GTP 0.001 0.001 -9999 0 -10000 0 0
GSK3B 0.018 0 -9999 0 -10000 0 0
GNAI2 0.007 0.075 -9999 0 -0.48 12 12
SIN3/HDAC complex 0.041 0.032 -9999 0 -0.27 5 5
GNAI1 -0.016 0.12 -9999 0 -0.38 46 46
XPO1 0.021 0.003 -9999 0 -10000 0 0
GLI1/Su(fu) -0.006 0.17 -9999 0 -0.58 25 25
SAP30 0.012 0.053 -9999 0 -0.48 6 6
mol:GDP -0.047 0.16 -9999 0 -0.41 82 82
MIM/GLI2A -0.022 0.14 -9999 0 -0.4 61 61
IFT88 -0.001 0.097 -9999 0 -0.48 20 20
GNAI3 0.019 0.001 -9999 0 -10000 0 0
GLI2 0.035 0.055 -9999 0 -0.41 1 1
GLI3 0.004 0.14 -9999 0 -0.38 29 29
CSNK1D 0.018 0 -9999 0 -10000 0 0
CSNK1E 0.017 0.012 -9999 0 -0.25 1 1
SAP18 0.017 0 -9999 0 -10000 0 0
embryonic digit morphogenesis -0.001 0.097 -9999 0 -0.48 20 20
GNG2 0.016 0.029 -9999 0 -0.34 3 3
Gi family/GTP -0.008 0.12 -9999 0 -0.38 25 25
SIN3B 0.017 0.012 -9999 0 -0.25 1 1
SIN3A 0.017 0 -9999 0 -10000 0 0
GLI3/Su(fu) 0.009 0.14 -9999 0 -0.43 35 35
GLI2/Su(fu) 0.026 0.1 -9999 0 -0.34 15 15
FOXA2 -0.051 0.18 -9999 0 -0.73 34 34
neural tube patterning 0.005 0.14 -9999 0 -0.54 18 18
SPOP 0.013 0.042 -9999 0 -0.33 7 7
Su(fu)/PIAS1 0.004 0.093 -9999 0 -0.34 21 21
GNB1 0.013 0.052 -9999 0 -0.52 5 5
CSNK1G2 0.016 0.033 -9999 0 -0.52 2 2
CSNK1G3 0.013 0.052 -9999 0 -0.52 5 5
MTSS1 -0.023 0.14 -9999 0 -0.4 61 61
embryonic limb morphogenesis 0.005 0.14 -9999 0 -0.54 18 18
SUFU -0.006 0.1 -9999 0 -0.38 21 21
LGALS3 -0.041 0.16 -9999 0 -0.48 63 63
catabolic process 0.031 0.12 -9999 0 -0.37 22 22
GLI3A/CBP 0.006 0.07 -9999 0 -0.36 10 10
KIF3A 0.007 0.074 -9999 0 -0.5 11 11
GLI1 0.005 0.14 -9999 0 -0.56 18 18
RAB23 0.008 0.065 -9999 0 -0.38 13 13
CSNK1A1 0.017 0.023 -9999 0 -0.52 1 1
IFT172 0.013 0.049 -9999 0 -0.43 6 6
RBBP7 0.01 0.051 -9999 0 -0.3 13 13
Su(fu)/Galectin3 -0.028 0.14 -9999 0 -0.34 71 71
GNAZ 0.002 0.088 -9999 0 -0.44 19 19
RBBP4 0.016 0.026 -9999 0 -0.39 2 2
CSNK1G1 0.017 0.012 -9999 0 -0.25 1 1
PIAS1 0.017 0.012 -9999 0 -0.25 1 1
PRKACA 0.018 0 -9999 0 -10000 0 0
GLI2/SPOP 0.04 0.057 -9999 0 -0.39 2 2
STK36 0 0.11 -9999 0 -0.52 21 21
Gi family/GNB1/GNG2/GDP 0 0.11 -9999 0 -0.36 28 28
PTCH1 0.014 0.13 -9999 0 -0.66 7 7
MIM/GLI1 0 0.16 -9999 0 -0.54 21 21
CREBBP 0.006 0.07 -9999 0 -0.36 10 10
Su(fu)/SIN3/HDAC complex 0.036 0.047 -9999 0 -0.26 1 1
ceramide signaling pathway

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 -0.009 0.13 -10000 0 -0.51 12 12
BAG4 0.002 0.07 -10000 0 -0.28 28 28
BAD 0.012 0.045 -10000 0 -0.18 9 9
NFKBIA 0.014 0.042 -10000 0 -0.45 4 4
BIRC3 -0.085 0.19 -10000 0 -0.41 128 128
BAX 0.011 0.045 -10000 0 -0.19 7 7
EnzymeConsortium:3.1.4.12 0.002 0.03 -10000 0 -0.11 12 12
IKBKB -0.003 0.12 -10000 0 -0.44 16 16
MAP2K2 0.023 0.046 -10000 0 -0.24 6 6
MAP2K1 0.024 0.043 -10000 0 -0.23 4 4
SMPD1 0.006 0.039 -10000 0 -0.19 9 9
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 -0.002 0.12 -10000 0 -0.42 19 19
MAP2K4 -0.011 0.089 -10000 0 -0.24 55 55
protein ubiquitination -0.003 0.12 -10000 0 -0.46 14 14
EnzymeConsortium:2.7.1.37 0.02 0.052 -10000 0 -0.26 4 4
response to UV 0 0 -10000 0 -0.002 4 4
RAF1 0.018 0.044 -10000 0 -0.22 4 4
CRADD 0.01 0.063 -10000 0 -0.49 8 8
mol:ceramide 0.005 0.046 -10000 0 -0.17 13 13
I-kappa-B-alpha/RELA/p50/ubiquitin 0.022 0.026 -10000 0 -0.31 3 3
MADD 0.018 0 -10000 0 -10000 0 0
MAP3K1 -0.009 0.083 -10000 0 -0.24 44 44
TRADD 0.016 0.026 -10000 0 -0.39 2 2
RELA/p50 0.018 0 -10000 0 -10000 0 0
MAPK3 0.027 0.044 -10000 0 -0.22 3 3
MAPK1 0.026 0.044 -10000 0 -0.22 3 3
p50/RELA/I-kappa-B-alpha 0.024 0.031 -10000 0 -0.37 3 3
FADD -0.011 0.13 -10000 0 -0.44 19 19
KSR1 0.012 0.045 -10000 0 -0.19 7 7
MAPK8 -0.004 0.086 -10000 0 -0.24 37 37
TRAF2 0.014 0.042 -10000 0 -0.45 4 4
response to radiation 0 0 -10000 0 -0.002 1 1
CHUK -0.007 0.13 -10000 0 -0.46 16 16
TNF R/SODD 0.014 0.054 -10000 0 -0.37 5 5
TNF -0.004 0.094 -10000 0 -0.36 31 31
CYCS 0.036 0.056 0.14 65 -0.17 5 70
IKBKG -0.001 0.12 -10000 0 -0.47 12 12
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD -0.011 0.13 -10000 0 -0.55 11 11
RELA 0.018 0 -10000 0 -10000 0 0
RIPK1 0.017 0.023 -10000 0 -0.52 1 1
AIFM1 0.037 0.056 0.14 65 -0.17 5 70
TNF/TNF R/SODD 0.012 0.074 -10000 0 -0.31 18 18
TNFRSF1A 0.016 0.033 -10000 0 -0.52 2 2
response to heat 0 0 -10000 0 -0.002 1 1
CASP8 0.021 0.032 -10000 0 -10000 0 0
NSMAF -0.007 0.13 -10000 0 -0.48 14 14
response to hydrogen peroxide 0 0 -10000 0 -0.002 4 4
BCL2 -0.11 0.22 -10000 0 -0.47 144 144
Regulation of p38-alpha and p38-beta

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.023 0.016 -9999 0 -0.31 1 1
response to insulin stimulus 0 0 -9999 0 -10000 0 0
RIPK1 0.017 0.023 -9999 0 -0.52 1 1
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 -0.011 0.11 -9999 0 -0.4 37 37
mol:GTP 0 0 -9999 0 -10000 0 0
MAP2K4 -0.006 0.1 -9999 0 -0.38 31 31
RAC1-CDC42/GTP/PAK family -0.001 0.072 -9999 0 -0.22 41 41
response to UV 0 0 -9999 0 -10000 0 0
YES1 0.007 0.07 -9999 0 -0.43 12 12
interleukin-1 receptor activity 0 0 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
MAP3K3 0.017 0.012 -9999 0 -0.25 1 1
FYN 0.008 0.067 -9999 0 -0.41 12 12
MAP3K12 0.018 0 -9999 0 -10000 0 0
FGR 0.017 0.017 -9999 0 -0.25 2 2
p38 alpha/TAB1 0.01 0.094 -9999 0 -0.28 29 29
PRKG1 0.017 0.012 -9999 0 -0.25 1 1
DUSP8 -0.005 0.1 -9999 0 -0.48 24 24
PGK/cGMP/p38 alpha -0.028 0.071 -9999 0 -0.26 32 32
apoptosis 0.009 0.09 -9999 0 -0.27 30 30
RAL/GTP 0.022 0.029 -9999 0 -0.31 4 4
LYN 0.014 0.031 -9999 0 -0.25 7 7
DUSP1 -0.038 0.15 -9999 0 -0.41 69 69
PAK1 -0.022 0.13 -9999 0 -0.37 54 54
SRC 0.015 0.035 -9999 0 -0.43 3 3
RAC1/OSM/MEKK3/MKK3 0.043 0.021 -9999 0 -0.27 1 1
TRAF6 0.017 0.023 -9999 0 -0.52 1 1
RAC1 0.018 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
mol:cGMP 0 0 -9999 0 -10000 0 0
CCM2 0.018 0 -9999 0 -10000 0 0
RAC1-CDC42/GTP 0.024 0 -9999 0 -10000 0 0
MAPK11 0.002 0.11 -9999 0 -0.32 34 34
BLK -0.019 0.1 -9999 0 -0.29 63 63
HCK -0.005 0.11 -9999 0 -0.47 25 25
MAP2K3 0.014 0.037 -9999 0 -0.29 7 7
DUSP16 0.005 0.078 -9999 0 -0.43 15 15
DUSP10 -0.017 0.12 -9999 0 -0.39 44 44
TRAF6/MEKK3 0.022 0.015 -9999 0 -0.28 1 1
MAP3K7IP1 0.018 0 -9999 0 -10000 0 0
MAPK14 0.003 0.1 -9999 0 -0.3 33 33
positive regulation of innate immune response 0.002 0.12 -9999 0 -0.37 31 31
LCK -0.074 0.18 -9999 0 -0.4 117 117
p38alpha-beta/MKP7 0.006 0.13 -9999 0 -0.36 36 36
p38alpha-beta/MKP5 -0.003 0.13 -9999 0 -0.35 40 40
PGK/cGMP 0.013 0.008 -9999 0 -0.17 1 1
PAK2 0.018 0 -9999 0 -10000 0 0
p38alpha-beta/MKP1 -0.013 0.14 -9999 0 -0.36 45 45
CDC42 0.018 0 -9999 0 -10000 0 0
RALB 0.014 0.047 -9999 0 -0.52 4 4
RALA 0.018 0 -9999 0 -10000 0 0
PAK3 -0.033 0.13 -9999 0 -0.32 80 80
S1P3 pathway

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.01 0.066 -9999 0 -0.52 8 8
mol:S1P 0 0.005 -9999 0 -0.015 43 43
S1P1/S1P/Gi 0 0.1 -9999 0 -0.4 16 16
GNAO1 0.016 0.024 -9999 0 -0.25 4 4
S1P/S1P3/G12/G13 0.02 0.031 -9999 0 -0.29 4 4
AKT1 0.012 0.097 -9999 0 -0.58 12 12
AKT3 0.004 0.14 -9999 0 -1.2 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB 0.01 0.066 -9999 0 -0.52 8 8
GNAI2 0.007 0.075 -9999 0 -0.48 12 12
GNAI3 0.018 0.004 -9999 0 -10000 0 0
GNAI1 -0.016 0.12 -9999 0 -0.38 46 46
mol:GDP 0 0 -9999 0 -10000 0 0
S1PR3 0.001 0.005 -9999 0 -0.017 43 43
S1PR2 0 0 -9999 0 -10000 0 0
EDG1 -0.019 0.12 -9999 0 -0.4 46 46
mol:Ca2+ 0.01 0.081 -9999 0 -0.29 15 15
MAPK3 0.016 0.078 -9999 0 -0.34 8 8
MAPK1 0.016 0.078 -9999 0 -0.33 9 9
JAK2 0.006 0.095 -9999 0 -0.34 19 19
CXCR4 -0.006 0.11 -9999 0 -0.31 42 42
FLT1 0.006 0.08 -9999 0 -0.45 15 15
RhoA/GDP 0.004 0.058 -9999 0 -0.38 12 12
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
SRC 0.015 0.08 -9999 0 -0.36 9 9
S1P/S1P3/Gi 0.01 0.082 -9999 0 -0.3 15 15
RAC1 0.018 0 -9999 0 -10000 0 0
RhoA/GTP 0.011 0.087 -9999 0 -0.3 18 18
VEGFA 0.001 0.076 -9999 0 -0.29 31 31
S1P/S1P2/Gi 0.009 0.076 -9999 0 -0.29 14 14
VEGFR1 homodimer/VEGFA homodimer 0.01 0.083 -9999 0 -0.39 15 15
RHOA 0.005 0.08 -9999 0 -0.52 12 12
S1P/S1P3/Gq -0.027 0.094 -9999 0 -0.27 58 58
GNAQ 0 0 -9999 0 -10000 0 0
GNAZ 0.002 0.088 -9999 0 -0.44 19 19
G12/G13 0.021 0.039 -9999 0 -0.37 4 4
GNA14 -0.079 0.18 -9999 0 -0.35 140 140
GNA15 0.002 0.076 -9999 0 -0.34 23 23
GNA12 0.018 0 -9999 0 -10000 0 0
GNA13 0.011 0.055 -9999 0 -0.36 10 10
GNA11 0.014 0.047 -9999 0 -0.52 4 4
Rac1/GTP 0.018 0.075 -9999 0 -0.34 7 7
ErbB2/ErbB3 signaling events

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 0.015 0.034 -10000 0 -0.32 4 4
RAS family/GTP 0.002 0.099 -10000 0 -0.33 22 22
NFATC4 0.007 0.079 -10000 0 -0.32 11 11
ERBB2IP 0.017 0.023 -10000 0 -0.52 1 1
HSP90 (dimer) 0.013 0.045 -10000 0 -0.39 6 6
mammary gland morphogenesis -0.01 0.094 -10000 0 -0.33 18 18
JUN 0.02 0.072 -10000 0 -10000 0 0
HRAS 0.012 0.051 -10000 0 -0.41 7 7
DOCK7 -0.002 0.092 -10000 0 -0.39 10 10
ErbB2/ErbB3/neuregulin 1 beta/SHC -0.013 0.1 -10000 0 -0.3 47 47
AKT1 0.008 0.038 -10000 0 -0.26 9 9
BAD 0.016 0.035 -10000 0 -0.31 5 5
MAPK10 0.003 0.069 -10000 0 -0.22 18 18
mol:GTP -0.001 0.002 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta -0.01 0.1 -10000 0 -0.36 18 18
RAF1 0.006 0.1 -10000 0 -0.34 20 20
ErbB2/ErbB3/neuregulin 2 -0.037 0.12 -10000 0 -0.34 57 57
STAT3 0.016 0.095 -10000 0 -0.95 5 5
cell migration 0.009 0.07 -10000 0 -0.21 16 16
mol:PI-3-4-5-P3 0 0.002 -10000 0 -10000 0 0
cell proliferation -0.045 0.24 -10000 0 -0.62 54 54
FOS -0.059 0.22 -10000 0 -0.45 106 106
NRAS 0.005 0.076 -10000 0 -0.4 16 16
mol:Ca2+ -0.01 0.094 -10000 0 -0.33 18 18
MAPK3 -0.021 0.19 -10000 0 -0.47 53 53
MAPK1 -0.021 0.19 -10000 0 -0.47 53 53
JAK2 -0.004 0.096 -10000 0 -0.39 13 13
NF2 0.003 0.01 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 0.001 0.082 -10000 0 -0.27 39 39
NRG1 0.007 0.053 -10000 0 -0.27 18 18
GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
MAPK8 -0.001 0.089 -10000 0 -0.29 22 22
MAPK9 0.008 0.067 -10000 0 -0.23 15 15
ERBB2 -0.03 0.082 -10000 0 -0.39 15 15
ERBB3 -0.019 0.14 -10000 0 -0.52 36 36
SHC1 0.016 0.023 -10000 0 -0.52 1 1
RAC1 0.018 0 -10000 0 -10000 0 0
apoptosis -0.01 0.041 0.35 5 -10000 0 5
STAT3 (dimer) 0.016 0.093 -10000 0 -0.93 5 5
RNF41 0.02 0.031 -10000 0 -0.28 4 4
FRAP1 0.016 0.032 -10000 0 -0.31 4 4
RAC1-CDC42/GTP -0.022 0.055 -10000 0 -0.27 10 10
ErbB2/ErbB2/HSP90 (dimer) -0.015 0.074 -10000 0 -0.32 18 18
CHRNA1 -0.008 0.16 -10000 0 -0.43 34 34
myelination 0.014 0.079 -10000 0 -0.32 11 11
PPP3CB -0.001 0.086 -10000 0 -0.37 9 9
KRAS 0.009 0.065 -10000 0 -0.44 10 10
RAC1-CDC42/GDP 0.021 0.074 -10000 0 -0.29 10 10
NRG2 -0.017 0.1 -10000 0 -0.3 57 57
mol:GDP 0.001 0.082 -10000 0 -0.27 39 39
SOS1 0.017 0.023 -10000 0 -0.52 1 1
MAP2K2 0.006 0.11 -10000 0 -0.35 21 21
SRC 0.015 0.035 -10000 0 -0.43 3 3
mol:cAMP -0.001 0.001 -10000 0 -10000 0 0
PTPN11 0 0.091 -10000 0 -0.4 9 9
MAP2K1 -0.024 0.17 -10000 0 -0.44 38 38
heart morphogenesis -0.01 0.094 -10000 0 -0.33 18 18
RAS family/GDP 0.013 0.099 -10000 0 -0.34 18 18
GRB2 0.015 0.024 -10000 0 -0.25 4 4
PRKACA -0.001 0.005 -10000 0 -10000 0 0
CHRNE 0.016 0.019 -10000 0 -10000 0 0
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
activation of caspase activity -0.008 0.038 0.26 9 -10000 0 9
nervous system development -0.01 0.094 -10000 0 -0.33 18 18
CDC42 0.018 0 -10000 0 -10000 0 0
BARD1 signaling events

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.021 0.042 -10000 0 -0.37 5 5
ATM 0.017 0.012 -10000 0 -0.25 1 1
UBE2D3 0.018 0 -10000 0 -10000 0 0
PRKDC 0.012 0.045 -10000 0 -0.31 9 9
ATR 0.017 0.012 -10000 0 -0.25 1 1
UBE2L3 0.018 0 -10000 0 -10000 0 0
FANCD2 0.029 0.012 -10000 0 -10000 0 0
protein ubiquitination 0.016 0.083 -10000 0 -0.28 26 26
XRCC5 0.018 0 -10000 0 -10000 0 0
XRCC6 0.017 0.012 -10000 0 -0.25 1 1
M/R/N Complex 0.03 0.045 -10000 0 -0.3 9 9
MRE11A 0.018 0 -10000 0 -10000 0 0
DNA-PK 0.032 0.028 -10000 0 -0.3 2 2
FA complex/FANCD2/Ubiquitin 0.028 0.075 -10000 0 -0.37 6 6
FANCF 0.012 0.057 -10000 0 -0.52 6 6
BRCA1 0 0.094 -10000 0 -0.48 19 19
CCNE1 -0.018 0.099 -10000 0 -0.28 64 64
CDK2/Cyclin E1 -0.002 0.08 -10000 0 -0.37 11 11
FANCG 0.016 0.024 -10000 0 -0.25 4 4
BRCA1/BACH1/BARD1 0.01 0.076 -10000 0 -0.37 20 20
FANCE 0.006 0.061 -10000 0 -0.3 19 19
FANCC 0.013 0.042 -10000 0 -0.33 7 7
NBN 0.015 0.035 -10000 0 -0.43 3 3
FANCA -0.032 0.12 -10000 0 -0.31 80 80
DNA repair 0.012 0.12 -10000 0 -0.38 25 25
BRCA1/BARD1/ubiquitin 0.01 0.076 -10000 0 -0.37 20 20
BARD1/DNA-PK 0.04 0.038 -10000 0 -0.27 6 6
FANCL 0.014 0.031 -10000 0 -0.25 7 7
mRNA polyadenylation -0.021 0.042 0.37 5 -10000 0 5
BRCA1/BARD1/CTIP/M/R/N Complex 0.026 0.057 -10000 0 -0.32 2 2
BRCA1/BACH1/BARD1/TopBP1 0.022 0.068 -10000 0 -0.31 20 20
BRCA1/BARD1/P53 0.01 0.11 -10000 0 -0.3 51 51
BARD1/CSTF1/BRCA1 0.02 0.069 -10000 0 -0.3 21 21
BRCA1/BACH1 0 0.094 -10000 0 -0.48 19 19
BARD1 0.014 0.047 -10000 0 -0.52 4 4
PCNA 0.009 0.064 -10000 0 -0.39 12 12
BRCA1/BARD1/UbcH5C 0.022 0.066 -10000 0 -0.3 20 20
BRCA1/BARD1/UbcH7 0.022 0.066 -10000 0 -0.3 20 20
BRCA1/BARD1/RAD51/PCNA -0.006 0.12 -10000 0 -0.28 74 74
BARD1/DNA-PK/P53 0.025 0.085 -10000 0 -0.25 43 43
BRCA1/BARD1/Ubiquitin 0.01 0.076 -10000 0 -0.37 20 20
BRCA1/BARD1/CTIP 0.015 0.081 -10000 0 -0.28 32 32
FA complex 0.017 0.073 -10000 0 -0.34 6 6
BARD1/EWS 0.023 0.034 -10000 0 -0.37 4 4
RBBP8 0.007 0.07 -10000 0 -0.37 12 12
TP53 -0.023 0.14 -10000 0 -0.48 43 43
TOPBP1 0.017 0.017 -10000 0 -0.25 2 2
G1/S transition of mitotic cell cycle -0.008 0.11 0.3 51 -10000 0 51
BRCA1/BARD1 0.02 0.085 -10000 0 -0.28 26 26
CSTF1 0.014 0.035 -10000 0 -0.3 6 6
BARD1/EWS-Fli1 0.01 0.034 -10000 0 -0.38 4 4
CDK2 0.012 0.047 -10000 0 -0.31 10 10
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 -0.041 0.16 -10000 0 -0.47 64 64
RAD50 0.011 0.062 -10000 0 -0.52 7 7
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.01 0.076 -10000 0 -0.37 20 20
EWSR1 0.018 0 -10000 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.02 0.089 -9999 0 -0.3 33 33
MAP4K1 0.012 0.04 -9999 0 -0.25 12 12
MAP3K8 -0.036 0.15 -9999 0 -0.39 70 70
PRKCB 0 0 -9999 0 -10000 0 0
DBNL 0.014 0.039 -9999 0 -0.36 5 5
CRKL 0.014 0.047 -9999 0 -0.52 4 4
MAP3K1 0.006 0.099 -9999 0 -0.35 12 12
JUN -0.008 0.092 -9999 0 -0.33 19 19
MAP3K7 0.029 0.065 -9999 0 -0.28 6 6
GRAP2 0.012 0.042 -9999 0 -0.28 10 10
CRK 0.016 0.033 -9999 0 -0.52 2 2
MAP2K4 0.006 0.094 -9999 0 -0.35 15 15
LAT 0.002 0.068 -9999 0 -0.27 29 29
LCP2 -0.004 0.097 -9999 0 -0.4 27 27
MAPK8 0.011 0.052 -9999 0 -0.58 3 3
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.024 0.069 -9999 0 -0.3 6 6
LAT/GRAP2/SLP76/HPK1/HIP-55 0.026 0.087 -9999 0 -0.3 27 27
Signaling events mediated by HDAC Class III

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.014 0.047 -10000 0 -0.52 4 4
HDAC4 0.017 0.023 -10000 0 -0.52 1 1
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle -0.011 0.027 0.24 3 -10000 0 3
CDKN1A -0.018 0.13 -10000 0 -0.71 16 16
KAT2B 0 0 -10000 0 -10000 0 0
BAX 0.016 0.02 -10000 0 -0.25 3 3
FOXO3 0.001 0.043 0.41 4 -0.25 4 8
FOXO1 0 0.092 -10000 0 -0.46 19 19
FOXO4 0.022 0.034 -10000 0 -0.27 7 7
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.017 0.012 -10000 0 -0.25 1 1
TAT -0.007 0.078 -10000 0 -0.25 48 48
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.011 0.091 -10000 0 -0.34 36 36
PPARGC1A -0.012 0.1 -10000 0 -0.31 48 48
FHL2 -0.077 0.19 -10000 0 -0.41 117 117
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.024 0.029 -10000 0 -0.37 1 1
HIST2H4A 0.011 0.027 -10000 0 -0.24 3 3
SIRT1/FOXO3a 0.005 0.041 0.32 4 -0.2 5 9
SIRT1 0.016 0.04 0.2 10 -0.35 3 13
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.034 0.029 -10000 0 -0.31 2 2
SIRT1/Histone H1b 0.004 0.072 -10000 0 -0.23 38 38
apoptosis -0.033 0.028 0.31 1 -10000 0 1
SIRT1/PGC1A 0.005 0.064 -10000 0 -0.32 11 11
p53/SIRT1 -0.016 0.11 0.4 10 -0.37 32 42
SIRT1/FOXO4 0.027 0.038 -10000 0 -0.24 7 7
FOXO1/FHL2/SIRT1 -0.03 0.12 -10000 0 -0.3 79 79
HIST1H1E -0.005 0.08 -10000 0 -0.27 39 39
SIRT1/p300 0.022 0.043 -10000 0 -0.36 5 5
muscle cell differentiation 0.002 0.081 0.31 30 -10000 0 30
TP53 -0.022 0.14 -10000 0 -0.47 43 43
KU70/SIRT1/BAX 0.033 0.028 -10000 0 -0.31 1 1
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
MEF2D 0.018 0 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 0.008 0.06 -10000 0 -0.37 1 1
ACSS2 0.023 0.029 -10000 0 -0.37 1 1
SIRT1/PCAF/MYOD -0.002 0.081 -10000 0 -0.32 30 30
Retinoic acid receptors-mediated signaling

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0.023 -10000 0 -0.52 1 1
HDAC3 0.018 0 -10000 0 -10000 0 0
VDR -0.003 0.1 -10000 0 -0.51 21 21
Cbp/p300/PCAF 0.02 0.036 -10000 0 -0.31 6 6
EP300 0.014 0.047 -10000 0 -0.52 4 4
RARs/AIB1/Cbp/p300/PCAF/9cRA 0.022 0.059 -10000 0 -0.28 3 3
KAT2B 0 0 -10000 0 -10000 0 0
MAPK14 0.017 0.012 -10000 0 -0.25 1 1
AKT1 0.03 0.093 0.22 54 -0.24 20 74
RAR alpha/9cRA/Cyclin H -0.024 0.062 -10000 0 -0.4 5 5
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA 0.014 0.07 -10000 0 -0.29 9 9
CDC2 -0.012 0.12 -10000 0 -0.44 34 34
response to UV -0.002 0.009 -10000 0 -10000 0 0
RAR alpha/Jnk1 0.015 0.049 -10000 0 -0.37 5 5
NCOR2 0.018 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 -0.002 0.075 -10000 0 -0.37 21 21
RXRs/RARs/NRIP1/9cRA -0.009 0.19 -10000 0 -0.54 53 53
NCOA2 0.009 0.063 -10000 0 -0.4 11 11
NCOA3 0.013 0.047 -10000 0 -0.37 7 7
NCOA1 0.012 0.057 -10000 0 -0.52 6 6
VDR/VDR/DNA -0.003 0.1 -10000 0 -0.51 21 21
RARG 0.016 0.024 -10000 0 -0.52 1 1
RAR gamma1/9cRA 0.022 0.016 -10000 0 -0.31 1 1
MAPK3 0.015 0.027 -10000 0 -0.39 2 2
MAPK1 0.016 0.033 -10000 0 -0.52 2 2
MAPK8 0.013 0.041 -10000 0 -0.52 3 3
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.002 0.12 -10000 0 -0.46 10 10
RARA 0.019 0.047 -10000 0 -0.25 8 8
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA 0.014 0.067 -10000 0 -0.26 7 7
PRKCA 0.011 0.038 -10000 0 -0.26 8 8
RXRs/RARs/NRIP1/9cRA/HDAC1 -0.026 0.21 -10000 0 -0.6 54 54
RXRG 0.014 0.063 -10000 0 -0.33 12 12
RXRA 0.011 0.08 -10000 0 -0.33 5 5
RXRB 0.021 0.041 -10000 0 -0.3 3 3
VDR/Vit D3/DNA -0.002 0.075 -10000 0 -0.37 21 21
RBP1 -0.076 0.19 -10000 0 -0.42 112 112
CRBP1/9-cic-RA -0.053 0.14 -10000 0 -0.3 112 112
RARB -0.025 0.13 -10000 0 -0.36 60 60
PRKCG 0.016 0.017 -10000 0 -10000 0 0
MNAT1 0.017 0.012 -10000 0 -0.25 1 1
RAR alpha/RXRs 0.02 0.15 -10000 0 -0.43 18 18
RXRs/RARs/SMRT(N-CoR2)/9cRA 0.023 0.11 -10000 0 -0.33 14 14
proteasomal ubiquitin-dependent protein catabolic process 0.021 0.064 -10000 0 -0.27 4 4
RXRs/RARs/NRIP1/9cRA/HDAC3 -0.026 0.21 -10000 0 -0.6 54 54
positive regulation of DNA binding -0.023 0.059 -10000 0 -0.38 5 5
NRIP1 -0.085 0.38 -10000 0 -1.2 53 53
RXRs/RARs -0.011 0.15 -10000 0 -0.42 55 55
RXRs/RXRs/DNA/9cRA 0.003 0.12 -10000 0 -0.4 9 9
PRKACA 0.018 0 -10000 0 -10000 0 0
CDK7 0.017 0.012 -10000 0 -0.25 1 1
TFIIH 0.033 0.031 -10000 0 -0.3 4 4
RAR alpha/9cRA 0.04 0.041 -10000 0 -0.27 3 3
CCNH 0.014 0.047 -10000 0 -0.52 4 4
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
RAR gamma2/9cRA -0.002 0.022 -10000 0 -10000 0 0
Signaling mediated by p38-alpha and p38-beta

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.002 0.14 -9999 0 -1.1 5 5
MKNK1 0.018 0 -9999 0 -10000 0 0
MAPK14 0.006 0.055 -9999 0 -0.29 6 6
ATF2/c-Jun -0.028 0.19 -9999 0 -0.64 44 44
MAPK11 0.006 0.053 -9999 0 -0.28 5 5
MITF 0.014 0.071 -9999 0 -0.34 11 11
MAPKAPK5 0.018 0.059 -9999 0 -0.33 5 5
KRT8 -0.004 0.1 -9999 0 -0.34 31 31
MAPKAPK3 0.017 0.017 -9999 0 -0.25 2 2
MAPKAPK2 0.014 0.047 -9999 0 -0.52 4 4
p38alpha-beta/CK2 0.009 0.074 -9999 0 -0.37 7 7
CEBPB 0.011 0.072 -9999 0 -0.32 11 11
SLC9A1 0.018 0.059 -9999 0 -0.33 5 5
mol:GDP 0 0 -9999 0 -10000 0 0
ATF2 0.013 0.079 -9999 0 -0.31 6 6
p38alpha-beta/MNK1 0.023 0.059 -9999 0 -0.32 5 5
JUN -0.028 0.19 -9999 0 -0.63 44 44
PPARGC1A 0.003 0.088 -9999 0 -0.35 15 15
USF1 0.006 0.084 -9999 0 -0.36 14 14
RAB5/GDP/GDI1 0.019 0.042 -9999 0 -0.22 6 6
NOS2 0.008 0.059 -9999 0 -0.3 7 7
DDIT3 0.014 0.066 -9999 0 -0.37 6 6
RAB5A 0.018 0 -9999 0 -10000 0 0
HSPB1 -0.012 0.12 -9999 0 -0.33 54 54
p38alpha-beta/HBP1 0.021 0.066 -9999 0 -0.34 8 8
CREB1 0.014 0.075 -9999 0 -0.28 17 17
RAB5/GDP 0.013 0 -9999 0 -10000 0 0
EIF4E 0.025 0.049 -9999 0 -0.27 5 5
RPS6KA4 0.018 0.061 -9999 0 -0.32 6 6
PLA2G4A -0.006 0.1 -9999 0 -0.31 30 30
GDI1 0.017 0.061 -9999 0 -0.32 6 6
TP53 -0.001 0.096 -9999 0 -0.34 21 21
RPS6KA5 0 0.1 -9999 0 -0.34 33 33
ESR1 -0.09 0.17 -9999 0 -0.33 155 155
HBP1 0.015 0.04 -9999 0 -0.52 3 3
MEF2C -0.001 0.1 -9999 0 -0.34 32 32
MEF2A 0.017 0.062 -9999 0 -0.33 6 6
EIF4EBP1 0.008 0.08 -9999 0 -0.29 18 18
KRT19 -0.014 0.12 -9999 0 -0.34 53 53
ELK4 0.016 0.065 -9999 0 -0.31 9 9
ATF6 0.018 0.06 -9999 0 -0.32 6 6
ATF1 0.014 0.076 -9999 0 -0.28 18 18
p38alpha-beta/MAPKAPK2 0.02 0.069 -9999 0 -0.37 8 8
p38alpha-beta/MAPKAPK3 0.022 0.059 -9999 0 -0.3 6 6
Signaling events mediated by VEGFR1 and VEGFR2

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin 0.001 0.094 -9999 0 -0.4 22 22
AKT1 0.029 0.15 -9999 0 -0.49 23 23
PTK2B 0.015 0.13 -9999 0 -0.56 15 15
VEGFR2 homodimer/Frs2 0.02 0.098 -9999 0 -0.52 12 12
CAV1 -0.001 0.083 -9999 0 -0.33 29 29
CALM1 0.018 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 0.019 0.11 -9999 0 -0.55 11 11
endothelial cell proliferation 0.046 0.13 -9999 0 -0.46 18 18
mol:Ca2+ 0.014 0.14 -9999 0 -0.57 17 17
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac 0.033 0.1 -9999 0 -0.54 10 10
RP11-342D11.1 0.005 0.14 -9999 0 -0.58 16 16
CDH5 0.013 0.052 -9999 0 -0.52 5 5
VEGFA homodimer 0.003 0.099 -9999 0 -0.27 52 52
SHC1 0.017 0.023 -9999 0 -0.52 1 1
SHC2 -0.06 0.19 -9999 0 -0.51 77 77
HRAS/GDP -0.036 0.099 -9999 0 -0.5 16 16
SH2D2A -0.039 0.15 -9999 0 -0.38 76 76
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS 0.044 0.12 -9999 0 -0.45 17 17
VEGFR2 homodimer/VEGFA homodimer/TsAd -0.008 0.14 -9999 0 -0.54 15 15
VEGFR1 homodimer 0.004 0.08 -9999 0 -0.45 15 15
SHC/GRB2/SOS1 0.026 0.13 -9999 0 -0.55 16 16
GRB10 0.005 0.17 -9999 0 -0.61 28 28
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
GRB2 0.016 0.024 -9999 0 -0.25 4 4
PAK1 -0.022 0.13 -9999 0 -0.37 54 54
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin 0.029 0.12 -9999 0 -0.52 15 15
HRAS 0.012 0.051 -9999 0 -0.41 7 7
VEGF/Rho/ROCK1/Integrin Complex 0.018 0.12 -9999 0 -0.56 13 13
HIF1A -0.037 0.16 -9999 0 -0.46 61 61
FRS2 0.011 0.047 -9999 0 -0.27 13 13
oxygen and reactive oxygen species metabolic process 0.031 0.1 -9999 0 -0.53 10 10
mol:GTP 0 0 -9999 0 -10000 0 0
FLT4 0.018 0 -9999 0 -10000 0 0
Nck/Pak -0.007 0.095 -9999 0 -0.37 25 25
VEGFR2 homodimer/VEGFA homodimer/Fyn 0.018 0.12 -9999 0 -0.63 11 11
mol:GDP -0.038 0.1 -9999 0 -0.53 16 16
mol:NADP 0.042 0.11 -9999 0 -0.4 17 17
eNOS/Hsp90 0.047 0.11 -9999 0 -0.38 16 16
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
mol:IP3 0.014 0.14 -9999 0 -0.58 17 17
HIF1A/ARNT -0.014 0.12 -9999 0 -0.37 47 47
SHB 0.008 0.067 -9999 0 -0.41 12 12
VEGFA -0.002 0.076 -9999 0 -0.28 31 31
VEGFC -0.001 0.095 -9999 0 -0.47 20 20
FAK1/Vinculin 0.034 0.13 -9999 0 -0.79 7 7
mol:Ca ++ 0 0 -9999 0 -10000 0 0
RHOA 0.005 0.08 -9999 0 -0.52 12 12
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.015 0.14 -9999 0 -0.6 15 15
PTPN6 0.015 0.035 -9999 0 -0.43 3 3
EPAS1 0.012 0.088 -9999 0 -0.46 16 16
mol:L-citrulline 0.042 0.11 -9999 0 -0.4 17 17
ITGAV -0.002 0.1 -9999 0 -0.48 21 21
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.028 0.11 -9999 0 -0.52 11 11
VEGFR2 homodimer/VEGFA homodimer 0.013 0.15 -9999 0 -0.64 16 16
VEGFR2/3 heterodimer 0.024 0.095 -9999 0 -0.56 10 10
VEGFB 0.017 0.023 -9999 0 -0.52 1 1
MAPK11 0.015 0.14 -9999 0 -0.56 19 19
VEGFR2 homodimer 0.018 0.11 -9999 0 -0.55 15 15
FLT1 0.004 0.08 -9999 0 -0.45 15 15
NEDD4 0.001 0.093 -9999 0 -0.53 15 15
MAPK3 0.017 0.13 -9999 0 -0.52 17 17
MAPK1 0.016 0.13 -9999 0 -0.52 17 17
VEGFA145/NRP2 0.009 0.065 -9999 0 -0.35 9 9
VEGFR1/2 heterodimer 0.016 0.11 -9999 0 -0.47 20 20
KDR 0.018 0.11 -9999 0 -0.55 15 15
VEGFA165/NRP1/VEGFR2 homodimer 0.017 0.14 -9999 0 -0.57 18 18
SRC 0.015 0.035 -9999 0 -0.43 3 3
platelet activating factor biosynthetic process 0.018 0.13 -9999 0 -0.54 17 17
PI3K 0.02 0.16 -9999 0 -0.57 23 23
VEGFR2 homodimer/VEGFA homodimer/NCK1 0.02 0.11 -9999 0 -0.57 10 10
FES 0.011 0.15 -9999 0 -0.62 16 16
GAB1 0.02 0.15 -9999 0 -0.56 18 18
VEGFR2 homodimer/VEGFA homodimer/Src 0.022 0.11 -9999 0 -0.57 10 10
CTNNB1 0.001 0.09 -9999 0 -0.45 19 19
SOS1 0.017 0.023 -9999 0 -0.52 1 1
ARNT 0.018 0 -9999 0 -10000 0 0
eNOS/Caveolin-1 0.041 0.12 -9999 0 -0.42 19 19
VEGFR2 homodimer/VEGFA homodimer/Yes 0.018 0.12 -9999 0 -0.54 13 13
PI3K/GAB1 0.027 0.16 -9999 0 -0.48 25 25
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak 0.013 0.12 -9999 0 -0.44 18 18
PRKACA 0.018 0 -9999 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer 0.024 0.12 -9999 0 -0.53 16 16
HSP90AA1 0.013 0.045 -9999 0 -0.39 6 6
CDC42 0.015 0.14 -9999 0 -0.6 16 16
actin cytoskeleton reorganization -0.008 0.13 -9999 0 -0.53 15 15
PTK2 0.026 0.14 -9999 0 -0.66 12 12
EDG1 -0.003 0.19 -9999 0 -0.64 31 31
mol:DAG 0.014 0.14 -9999 0 -0.58 17 17
CaM/Ca2+ 0.021 0.13 -9999 0 -0.53 17 17
MAP2K3 0.015 0.14 -9999 0 -0.55 19 19
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 0.011 0.18 -9999 0 -0.62 28 28
PLCG1 0.014 0.14 -9999 0 -0.59 17 17
VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.027 0.11 -9999 0 -0.48 15 15
IQGAP1 0.018 0 -9999 0 -10000 0 0
YES1 0.007 0.07 -9999 0 -0.43 12 12
VEGFR2 homodimer/VEGFA homodimer/SHP2 0.023 0.11 -9999 0 -0.57 11 11
VEGFR2 homodimer/VEGFA homodimer/SHP1 0.022 0.11 -9999 0 -0.57 10 10
cell migration 0.055 0.12 -9999 0 -0.64 8 8
mol:PI-3-4-5-P3 0.021 0.15 -9999 0 -0.53 23 23
FYN 0.008 0.067 -9999 0 -0.41 12 12
VEGFB/NRP1 0.014 0.13 -9999 0 -0.56 16 16
mol:NO 0.042 0.11 -9999 0 -0.4 17 17
PXN 0.018 0 -9999 0 -10000 0 0
HRAS/GTP -0.036 0.098 -9999 0 -0.5 16 16
VEGFR2 homodimer/VEGFA homodimer/GRB10 0.009 0.17 -9999 0 -0.62 28 28
VHL 0.015 0.029 -9999 0 -0.25 6 6
ITGB3 0.002 0.075 -9999 0 -0.32 25 25
NOS3 0.041 0.12 -9999 0 -0.45 17 17
VEGFR2 homodimer/VEGFA homodimer/Sck -0.021 0.15 -9999 0 -0.48 25 25
RAC1 0.018 0 -9999 0 -10000 0 0
PRKCA 0.019 0.13 -9999 0 -0.5 20 20
PRKCB 0.012 0.13 -9999 0 -0.54 17 17
VCL 0.016 0.029 -9999 0 -0.34 3 3
VEGFA165/NRP1 0.008 0.14 -9999 0 -0.59 16 16
VEGFR1/2 heterodimer/VEGFA homodimer 0.016 0.12 -9999 0 -0.57 14 14
VEGFA165/NRP2 0.009 0.065 -9999 0 -0.35 9 9
MAPKKK cascade 0.031 0.15 -9999 0 -0.51 28 28
NRP2 0.011 0.052 -9999 0 -0.33 11 11
VEGFC homodimer -0.001 0.095 -9999 0 -0.47 20 20
NCK1 0.011 0.045 -9999 0 -0.28 12 12
ROCK1 0.018 0 -9999 0 -10000 0 0
FAK1/Paxillin 0.035 0.13 -9999 0 -0.78 7 7
MAP3K13 0.01 0.15 -9999 0 -0.58 19 19
PDPK1 0.027 0.14 -9999 0 -0.47 23 23
Neurotrophic factor-mediated Trk receptor signaling

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.014 0.047 -10000 0 -0.52 4 4
RAS family/GTP/Tiam1 0.003 0.08 -10000 0 -0.28 28 28
NT3 (dimer)/TRKC -0.019 0.093 -10000 0 -0.35 17 17
NT3 (dimer)/TRKB -0.015 0.1 -10000 0 -0.32 37 37
SHC/Grb2/SOS1/GAB1/PI3K 0.023 0.065 -10000 0 -10000 0 0
RAPGEF1 0.018 0 -10000 0 -10000 0 0
BDNF -0.016 0.091 -10000 0 -0.26 64 64
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
DYNLT1 0.018 0 -10000 0 -10000 0 0
NTRK1 0.01 0.053 -10000 0 -0.32 12 12
NTRK2 -0.017 0.11 -10000 0 -0.34 52 52
NTRK3 -0.009 0.081 -10000 0 -0.25 53 53
NT-4/5 (dimer)/TRKB -0.004 0.079 -10000 0 -0.31 23 23
neuron apoptosis 0.036 0.15 0.34 79 -10000 0 79
SHC 2-3/Grb2 -0.039 0.16 -10000 0 -0.37 79 79
SHC1 0.017 0.023 -10000 0 -0.52 1 1
SHC2 -0.061 0.2 -10000 0 -0.5 78 78
SHC3 -0.007 0.11 -10000 0 -0.46 18 18
STAT3 (dimer) -0.045 0.14 -10000 0 -0.34 89 89
NT3 (dimer)/TRKA 0.001 0.083 -10000 0 -0.33 17 17
RIN/GDP 0.047 0.05 -10000 0 -0.24 3 3
GIPC1 0.014 0.042 -10000 0 -0.45 4 4
KRAS 0.009 0.065 -10000 0 -0.44 10 10
DNAJA3 0.017 0.066 0.23 21 -0.26 6 27
RIN/GTP 0.011 0.025 -10000 0 -0.31 3 3
CCND1 -0.12 0.29 -10000 0 -0.75 89 89
MAGED1 -0.008 0.11 -10000 0 -0.48 27 27
PTPN11 0.017 0.023 -10000 0 -0.52 1 1
RICS 0.003 0.083 -10000 0 -0.45 16 16
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.034 0.025 -10000 0 -0.3 2 2
GRB2 0.016 0.024 -10000 0 -0.25 4 4
NGF (dimer)/TRKA/MATK 0.008 0.054 -10000 0 -0.3 7 7
TRKA/NEDD4-2 -0.01 0.11 -10000 0 -0.37 39 39
ELMO1 0.017 0.017 -10000 0 -0.25 2 2
RhoG/GTP/ELMO1/DOCK1 0.016 0.049 -10000 0 -0.31 11 11
NGF 0 0 -10000 0 -10000 0 0
HRAS 0.012 0.051 -10000 0 -0.41 7 7
DOCK1 0.006 0.078 -10000 0 -0.5 12 12
GAB2 0.009 0.048 -10000 0 -0.25 17 17
RIT2 0.015 0.035 -10000 0 -0.43 3 3
RIT1 0.016 0.033 -10000 0 -0.52 2 2
FRS2 0.011 0.047 -10000 0 -0.27 13 13
DNM1 0.013 0.047 -10000 0 -0.37 7 7
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.016 0.033 -10000 0 -0.52 2 2
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP 0.018 0.064 0.22 21 -0.25 6 27
mol:GDP 0.053 0.065 -10000 0 -0.4 2 2
NGF (dimer) 0 0 -10000 0 -10000 0 0
RhoG/GDP 0.012 0.011 -10000 0 -0.17 2 2
RIT1/GDP 0.048 0.049 -10000 0 -0.26 2 2
TIAM1 0.006 0.073 -10000 0 -0.44 13 13
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
BDNF (dimer)/TRKB -0.007 0.09 -10000 0 -0.32 24 24
KIDINS220/CRKL/C3G 0.023 0.034 -10000 0 -0.37 4 4
SHC/RasGAP 0.016 0.059 -10000 0 -0.37 11 11
FRS2 family/SHP2 0.031 0.032 -10000 0 -0.3 2 2
SHC/GRB2/SOS1/GAB1 0.037 0.049 -10000 0 -0.26 12 12
RIT1/GTP 0.012 0.024 -10000 0 -0.38 2 2
NT3 (dimer) -0.021 0.11 -10000 0 -0.28 68 68
RAP1/GDP -0.006 0.028 -10000 0 -0.26 2 2
KIDINS220/CRKL 0.014 0.047 -10000 0 -0.52 4 4
BDNF (dimer) -0.016 0.09 -10000 0 -0.26 64 64
ubiquitin-dependent protein catabolic process -0.007 0.091 -10000 0 -0.31 39 39
Schwann cell development -0.008 0.017 -10000 0 -10000 0 0
EHD4 0.013 0.052 -10000 0 -0.52 5 5
FRS2 family/GRB2/SOS1 0.04 0.037 -10000 0 -0.39 2 2
FRS2 family/SHP2/CRK family/C3G/GAB2 0.038 0.037 -10000 0 -0.23 6 6
RAP1B 0.013 0.044 -10000 0 -0.32 8 8
RAP1A 0.012 0.057 -10000 0 -0.52 6 6
CDC42/GTP -0.043 0.077 -10000 0 -0.35 14 14
ABL1 0.018 0 -10000 0 -10000 0 0
SH2B family/GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
Rap1/GTP 0.032 0.072 -10000 0 -0.39 8 8
STAT3 -0.045 0.14 -10000 0 -0.34 89 89
axon guidance -0.041 0.074 -10000 0 -0.34 14 14
MAPK3 0.013 0.05 -10000 0 -0.26 8 8
MAPK1 0.013 0.052 -10000 0 -0.27 9 9
CDC42/GDP 0.048 0.048 -10000 0 -0.26 2 2
NTF3 -0.021 0.11 -10000 0 -0.28 68 68
NTF4 0 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM 0.018 0.036 -10000 0 -0.31 4 4
PI3K 0.005 0.082 -10000 0 -0.37 21 21
FRS3 0.017 0.012 -10000 0 -0.25 1 1
FAIM 0.016 0.029 -10000 0 -0.34 3 3
GAB1 0.006 0.074 -10000 0 -0.43 14 14
RASGRF1 0.007 0.076 0.23 20 -0.26 12 32
SOS1 0.017 0.023 -10000 0 -0.52 1 1
MCF2L -0.009 0.083 -10000 0 -0.3 21 21
RGS19 0.014 0.039 -10000 0 -0.36 5 5
CDC42 0.018 0 -10000 0 -10000 0 0
RAS family/GTP 0.047 0.07 -10000 0 -0.38 7 7
Rac1/GDP 0.048 0.048 -10000 0 -0.26 2 2
NGF (dimer)/TRKA/GRIT 0.011 0.06 -10000 0 -0.31 15 15
neuron projection morphogenesis -0.013 0.13 -10000 0 -0.53 10 10
NGF (dimer)/TRKA/NEDD4-2 -0.007 0.091 -10000 0 -0.31 39 39
MAP2K1 0.034 0.045 -10000 0 -0.24 11 11
NGFR 0.004 0.065 -10000 0 -0.29 23 23
NGF (dimer)/TRKA/GIPC/GAIP 0.028 0.047 -10000 0 -0.27 10 10
RAS family/GTP/PI3K 0.011 0.077 -10000 0 -0.25 39 39
FRS2 family/SHP2/GRB2/SOS1 0.047 0.037 -10000 0 -0.38 2 2
NRAS 0.005 0.076 -10000 0 -0.4 16 16
GRB2/SOS1 0.024 0.023 -10000 0 -0.37 1 1
PRKCI 0.002 0.085 -10000 0 -0.43 18 18
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.018 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
MAPKKK cascade -0.018 0.052 -10000 0 -0.48 4 4
RASA1 0.004 0.078 -10000 0 -0.42 16 16
TRKA/c-Abl 0.021 0.038 -10000 0 -0.37 3 3
SQSTM1 0.012 0.053 -10000 0 -0.48 6 6
BDNF (dimer)/TRKB/GIPC 0.007 0.081 -10000 0 -0.28 22 22
NGF (dimer)/TRKA/p62/Atypical PKCs 0.017 0.059 -10000 0 -0.26 20 20
MATK -0.003 0.075 -10000 0 -0.27 38 38
NEDD4L -0.025 0.14 -10000 0 -0.45 48 48
RAS family/GDP -0.01 0.033 -10000 0 -0.28 1 1
NGF (dimer)/TRKA 0.009 0.07 0.24 21 -0.19 25 46
Rac1/GTP -0.02 0.052 -10000 0 -0.22 19 19
FRS2 family/SHP2/CRK family 0.045 0.043 -10000 0 -0.26 8 8
Paxillin-independent events mediated by a4b1 and a4b7

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.017 0.079 -9999 0 -0.37 18 18
CRKL 0.014 0.047 -9999 0 -0.52 4 4
Rac1/GDP 0.013 0 -9999 0 -10000 0 0
DOCK1 0.006 0.078 -9999 0 -0.5 12 12
ITGA4 -0.007 0.1 -9999 0 -0.39 32 32
alpha4/beta7 Integrin/MAdCAM1 0.023 0.079 -9999 0 -0.29 27 27
EPO -0.023 0.097 -9999 0 -0.25 80 80
alpha4/beta7 Integrin 0.009 0.074 -9999 0 -0.37 16 16
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.016 0.033 -9999 0 -0.52 2 2
alpha4/beta1 Integrin 0.006 0.084 -9999 0 -0.41 17 17
EPO/EPOR (dimer) -0.003 0.069 -9999 0 -0.32 2 2
lamellipodium assembly 0.022 0.069 -9999 0 -0.35 6 6
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
PI3K 0.005 0.082 -9999 0 -0.37 21 21
ARF6 0.016 0.033 -9999 0 -0.52 2 2
JAK2 0.007 0.079 -9999 0 -0.39 10 10
PXN 0.018 0 -9999 0 -10000 0 0
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
MADCAM1 0.014 0.033 -9999 0 -0.25 8 8
cell adhesion 0.021 0.079 -9999 0 -0.29 27 27
CRKL/CBL 0.023 0.035 -9999 0 -0.37 4 4
ITGB1 0.014 0.044 -9999 0 -0.41 5 5
SRC -0.001 0.11 -9999 0 -0.31 48 48
ITGB7 0.018 0 -9999 0 -10000 0 0
RAC1 0.018 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 -0.005 0.12 -9999 0 -0.35 46 46
p130Cas/Crk/Dock1 0.018 0.1 -9999 0 -0.46 8 8
VCAM1 -0.022 0.13 -9999 0 -0.42 48 48
RHOA 0.005 0.08 -9999 0 -0.52 12 12
alpha4/beta1 Integrin/Paxillin/GIT1 0.028 0.07 -9999 0 -0.3 18 18
BCAR1 0.006 0.1 -9999 0 -0.29 42 42
EPOR 0.016 0.02 -9999 0 -0.25 3 3
mol:GDP 0 0 -9999 0 -10000 0 0
CBL 0.017 0.012 -9999 0 -0.25 1 1
GIT1 0.014 0.035 -9999 0 -0.3 6 6
Rac1/GTP 0.022 0.071 -9999 0 -0.36 6 6
VEGFR1 specific signals

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer -0.009 0.14 -9999 0 -0.7 13 13
VEGFR1 homodimer/NRP1 -0.021 0.14 -9999 0 -0.39 56 56
mol:DAG -0.004 0.14 -9999 0 -0.66 12 12
VEGFR1 homodimer/NRP1/VEGFR 121 -0.017 0.14 -9999 0 -0.64 14 14
CaM/Ca2+ 0.006 0.13 -9999 0 -0.63 12 12
HIF1A -0.035 0.17 -9999 0 -0.51 56 56
GAB1 0.006 0.074 -9999 0 -0.43 14 14
AKT1 -0.001 0.14 -9999 0 -0.57 17 17
PLCG1 -0.004 0.14 -9999 0 -0.67 12 12
NOS3 0.018 0.12 -9999 0 -0.56 13 13
CBL 0.017 0.012 -9999 0 -0.25 1 1
mol:NO 0.019 0.12 -9999 0 -0.53 13 13
FLT1 -0.021 0.16 -9999 0 -0.45 56 56
PGF 0.012 0.051 -9999 0 -0.41 7 7
VEGFR1 homodimer/NRP2/VEGFR121 -0.01 0.14 -9999 0 -0.64 15 15
CALM1 0.018 0 -9999 0 -10000 0 0
PIK3CA 0.016 0.029 -9999 0 -0.34 3 3
eNOS/Hsp90 0.026 0.12 -9999 0 -0.54 12 12
endothelial cell proliferation 0 0.13 -9999 0 -0.6 14 14
mol:Ca2+ -0.004 0.13 -9999 0 -0.66 12 12
MAPK3 0.007 0.12 -9999 0 -0.57 13 13
MAPK1 0.007 0.12 -9999 0 -0.58 12 12
PIK3R1 -0.009 0.11 -9999 0 -0.42 33 33
PLGF homodimer 0.012 0.051 -9999 0 -0.41 7 7
PRKACA 0.018 0 -9999 0 -10000 0 0
RP11-342D11.1 0 0 -9999 0 -10000 0 0
CAV1 -0.001 0.083 -9999 0 -0.33 29 29
VEGFA homodimer 0 0.075 -9999 0 -0.29 31 31
VEGFR1 homodimer/VEGFA homodimer -0.019 0.15 -9999 0 -0.68 14 14
platelet activating factor biosynthetic process 0.012 0.12 -9999 0 -0.57 12 12
PI3K -0.004 0.15 -9999 0 -0.61 16 16
PRKCA 0.001 0.13 -9999 0 -0.61 12 12
PRKCB -0.005 0.13 -9999 0 -0.62 12 12
VEGFR1 homodimer/PLGF homodimer -0.012 0.15 -9999 0 -0.7 13 13
VEGFA 0 0.075 -9999 0 -0.29 31 31
VEGFB 0.017 0.023 -9999 0 -0.52 1 1
mol:IP3 -0.004 0.14 -9999 0 -0.66 12 12
RASA1 -0.008 0.14 -9999 0 -0.67 13 13
NRP2 0.011 0.052 -9999 0 -0.33 11 11
VEGFR1 homodimer -0.021 0.16 -9999 0 -0.45 56 56
VEGFB homodimer 0.017 0.023 -9999 0 -0.52 1 1
NCK1 0.011 0.045 -9999 0 -0.28 12 12
eNOS/Caveolin-1 0.02 0.13 -9999 0 -0.57 14 14
PTPN11 0.017 0.023 -9999 0 -0.52 1 1
mol:PI-3-4-5-P3 -0.005 0.14 -9999 0 -0.6 16 16
mol:L-citrulline 0.019 0.12 -9999 0 -0.53 13 13
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.004 0.13 -9999 0 -0.62 13 13
VEGFR1 homodimer/VEGFA homodimer/NCK1 -0.009 0.14 -9999 0 -0.65 14 14
CD2AP 0.016 0.029 -9999 0 -0.34 3 3
PI3K/GAB1 -0.001 0.14 -9999 0 -0.56 17 17
PDPK1 -0.003 0.13 -9999 0 -0.56 16 16
VEGFR1 homodimer/VEGFA homodimer/SHP2 -0.007 0.14 -9999 0 -0.63 14 14
mol:NADP 0.019 0.12 -9999 0 -0.53 13 13
HSP90AA1 0.013 0.045 -9999 0 -0.39 6 6
ubiquitin-dependent protein catabolic process 0.003 0.13 -9999 0 -0.61 13 13
VEGFR1 homodimer/NRP2 -0.013 0.15 -9999 0 -0.69 14 14
LPA4-mediated signaling events

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 0.011 0.053 -9999 0 -0.31 13 13
ADCY5 -0.01 0.074 -9999 0 -0.32 15 15
ADCY6 0.014 0.042 -9999 0 -0.31 8 8
ADCY7 0.007 0.06 -9999 0 -0.32 14 14
ADCY1 0.015 0.038 -9999 0 -0.31 6 6
ADCY2 -0.03 0.11 -9999 0 -0.33 51 51
ADCY3 0.01 0.054 -9999 0 -0.31 13 13
ADCY8 0.011 0.046 -9999 0 -0.31 7 7
PRKCE 0.007 0.044 -9999 0 -0.31 9 9
ADCY9 0.002 0.075 -9999 0 -0.33 24 24
mol:DAG 0 0 -9999 0 -10000 0 0
cAMP biosynthetic process -0.002 0.072 -9999 0 -0.28 18 18
a4b1 and a4b7 Integrin signaling

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.014 0.044 -9999 0 -0.41 5 5
ITGB7 0.018 0 -9999 0 -10000 0 0
ITGA4 -0.007 0.1 -9999 0 -0.39 32 32
alpha4/beta7 Integrin 0.009 0.074 -9999 0 -0.37 16 16
alpha4/beta1 Integrin 0.006 0.084 -9999 0 -0.41 17 17
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.014 0.053 -10000 0 -0.37 4 4
CRKL 0.02 0.086 -10000 0 -0.44 12 12
mol:PIP3 -0.004 0.091 0.46 19 -10000 0 19
AKT1 0.007 0.068 0.34 18 -0.28 4 22
PTK2B 0.017 0.017 -10000 0 -0.25 2 2
RAPGEF1 0.026 0.082 -10000 0 -0.42 11 11
RANBP10 0.018 0 -10000 0 -10000 0 0
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
HGF/MET/SHIP2 0.016 0.071 -10000 0 -0.31 18 18
MAP3K5 0.018 0.099 -10000 0 -0.41 14 14
HGF/MET/CIN85/CBL/ENDOPHILINS 0.021 0.079 -10000 0 -0.29 24 24
AP1 -0.087 0.16 -10000 0 -0.37 110 110
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.017 0.023 -10000 0 -0.52 1 1
apoptosis -0.14 0.3 -10000 0 -0.74 100 100
STAT3 (dimer) 0.029 0.058 -10000 0 -0.29 2 2
GAB1/CRKL/SHP2/PI3K 0.029 0.098 -10000 0 -0.4 15 15
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK 0.03 0.081 -10000 0 -0.44 10 10
PTPN11 0.017 0.023 -10000 0 -0.52 1 1
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.016 0.026 -10000 0 -0.39 2 2
PTEN -0.002 0.1 -10000 0 -0.52 19 19
ELK1 -0.005 0.036 0.25 3 -0.18 5 8
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 0.023 0.045 -10000 0 -0.23 7 7
PAK1 -0.005 0.089 0.32 17 -0.26 29 46
HGF/MET/RANBP10 0.02 0.063 -10000 0 -0.31 13 13
HRAS 0.025 0.077 -10000 0 -0.52 6 6
DOCK1 0.021 0.093 -10000 0 -0.47 11 11
GAB1 0.016 0.087 -10000 0 -0.43 14 14
CRK 0.021 0.084 -10000 0 -0.45 11 11
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP 0.021 0.083 -10000 0 -0.49 12 12
JUN -0.034 0.15 -10000 0 -0.46 57 57
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET 0.005 0.05 -10000 0 -0.24 17 17
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
cell morphogenesis 0.039 0.088 -10000 0 -0.36 9 9
GRB2/SHC 0.024 0.049 -10000 0 -0.23 11 11
FOS -0.11 0.2 -10000 0 -0.37 171 171
GLMN -0.001 0.014 -10000 0 -0.25 1 1
cell motility -0.005 0.036 0.25 3 -0.18 5 8
HGF/MET/MUC20 0.008 0.062 -10000 0 -0.32 13 13
cell migration 0.024 0.048 -10000 0 -0.23 11 11
GRB2 0.016 0.024 -10000 0 -0.25 4 4
CBL 0.017 0.012 -10000 0 -0.25 1 1
MET/RANBP10 0.014 0.053 -10000 0 -0.37 4 4
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.025 0.059 -10000 0 -0.3 2 2
MET/MUC20 0.001 0.052 -10000 0 -0.2 31 31
RAP1B 0.03 0.08 -10000 0 -0.39 12 12
RAP1A 0.03 0.087 -10000 0 -0.44 12 12
HGF/MET/RANBP9 0.019 0.063 -10000 0 -0.31 13 13
RAF1 0.031 0.073 -10000 0 -0.48 6 6
STAT3 0.029 0.059 -10000 0 -0.29 2 2
cell proliferation 0.037 0.07 -10000 0 -0.32 13 13
RPS6KB1 0.009 0.023 -10000 0 -0.15 1 1
MAPK3 -0.01 0.04 0.66 1 -10000 0 1
MAPK1 -0.009 0.055 0.76 2 -10000 0 2
RANBP9 0.017 0.012 -10000 0 -0.25 1 1
MAPK8 0.025 0.093 -10000 0 -0.4 8 8
SRC 0.029 0.058 -10000 0 -0.28 2 2
PI3K 0.011 0.077 -10000 0 -0.26 29 29
MET/Glomulin 0.005 0.047 -10000 0 -0.3 5 5
SOS1 0.017 0.023 -10000 0 -0.52 1 1
MAP2K1 0.037 0.069 -10000 0 -0.44 6 6
MET 0 0.075 -10000 0 -0.29 31 31
MAP4K1 0.03 0.081 -10000 0 -0.46 9 9
PTK2 0.016 0.029 -10000 0 -0.34 3 3
MAP2K2 0.036 0.073 -10000 0 -0.47 6 6
BAD 0.013 0.064 0.32 18 -0.26 5 23
MAP2K4 0.015 0.1 -10000 0 -0.35 17 17
SHP2/GRB2/SOS1/GAB1 -0.016 0.067 -10000 0 -0.38 13 13
INPPL1 0.012 0.055 -10000 0 -0.44 7 7
PXN 0.018 0 -10000 0 -10000 0 0
SH3KBP1 0 0.086 -10000 0 -0.38 23 23
HGS 0.012 0.048 -10000 0 -0.22 18 18
PLCgamma1/PKC 0.012 0.019 -10000 0 -0.27 2 2
HGF 0.008 0.069 -10000 0 -0.45 11 11
RASA1 0.004 0.078 -10000 0 -0.42 16 16
NCK1 0.011 0.045 -10000 0 -0.28 12 12
PTPRJ 0.012 0.055 -10000 0 -0.44 7 7
NCK/PLCgamma1 0.024 0.055 -10000 0 -0.24 12 12
PDPK1 0.003 0.07 0.37 18 -10000 0 18
HGF/MET/SHIP 0.008 0.062 -10000 0 -0.32 13 13
EPO signaling pathway

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.029 0.17 -10000 0 -0.44 13 13
CRKL 0.006 0.074 -10000 0 -0.3 8 8
mol:DAG 0.006 0.083 -10000 0 -0.27 5 5
HRAS 0.024 0.075 -10000 0 -0.41 2 2
MAPK8 0.009 0.058 -10000 0 -0.28 4 4
RAP1A 0.005 0.077 -10000 0 -0.32 9 9
GAB1 0.002 0.08 -10000 0 -0.28 13 13
MAPK14 0.011 0.054 -10000 0 -0.22 2 2
EPO -0.025 0.098 -10000 0 -0.26 80 80
PLCG1 0.006 0.084 -10000 0 -0.28 5 5
EPOR/TRPC2/IP3 Receptors 0.013 0.024 -10000 0 -0.27 3 3
RAPGEF1 0.018 0 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 0.001 0.073 -10000 0 -0.32 10 10
GAB1/SHC/GRB2/SOS1 0.02 0.074 -10000 0 -0.43 2 2
EPO/EPOR (dimer) -0.005 0.071 -10000 0 -0.28 3 3
IRS2 -0.013 0.1 -10000 0 -0.31 34 34
STAT1 -0.026 0.14 -10000 0 -0.32 61 61
STAT5B -0.002 0.1 -10000 0 -0.28 8 8
cell proliferation 0.016 0.054 -10000 0 -0.27 3 3
GAB1/SHIP/PIK3R1/SHP2/SHC -0.031 0.066 -10000 0 -0.31 12 12
TEC 0.005 0.074 -10000 0 -0.28 9 9
SOCS3 0.005 0.074 -10000 0 -0.38 17 17
STAT1 (dimer) -0.026 0.14 -10000 0 -0.31 61 61
JAK2 0.008 0.054 -10000 0 -0.32 12 12
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
EPO/EPOR (dimer)/JAK2 0.015 0.083 -10000 0 -0.29 6 6
EPO/EPOR -0.005 0.071 -10000 0 -0.28 3 3
LYN 0.012 0.033 -10000 0 -0.26 7 7
TEC/VAV2 0.014 0.076 -10000 0 -0.29 6 6
elevation of cytosolic calcium ion concentration 0.013 0.023 -10000 0 -0.27 3 3
SHC1 0.017 0.023 -10000 0 -0.52 1 1
EPO/EPOR (dimer)/LYN 0.009 0.066 -10000 0 -0.26 2 2
mol:IP3 0.006 0.083 -10000 0 -0.27 5 5
PI3K regualtory subunit polypeptide 1/IRS2/SHIP -0.017 0.11 -10000 0 -0.32 39 39
SH2B3 0.015 0.024 -10000 0 -0.52 1 1
NFKB1 0.01 0.055 -10000 0 -0.27 2 2
EPO/EPOR (dimer)/JAK2/SOCS3 -0.004 0.05 0.26 1 -0.23 11 12
PTPN6 0 0.072 -10000 0 -0.29 6 6
TEC/VAV2/GRB2 0.021 0.074 -10000 0 -0.33 3 3
EPOR 0.013 0.024 -10000 0 -0.27 3 3
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.019 0.075 -10000 0 -0.44 2 2
SOS1 0.017 0.023 -10000 0 -0.52 1 1
PLCG2 -0.017 0.11 -10000 0 -0.32 55 55
CRKL/CBL/C3G 0.023 0.073 -10000 0 -0.36 3 3
VAV2 0.007 0.071 -10000 0 -0.3 4 4
CBL 0.008 0.07 -10000 0 -0.3 4 4
SHC/Grb2/SOS1 -0.021 0.044 -10000 0 -0.27 5 5
STAT5A -0.005 0.11 -10000 0 -0.31 9 9
GRB2 0.016 0.024 -10000 0 -0.25 4 4
STAT5 (dimer) -0.013 0.15 -10000 0 -0.35 40 40
LYN/PLCgamma2 -0.002 0.082 -10000 0 -0.36 16 16
PTPN11 0.017 0.023 -10000 0 -0.52 1 1
BTK -0.005 0.092 -10000 0 -0.31 23 23
BCL2 -0.15 0.38 -10000 0 -0.86 117 117
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.018 0 -10000 0 -10000 0 0
NFATC1 0.033 0.073 -10000 0 -10000 0 0
NFATC2 0.027 0.041 -10000 0 -0.25 1 1
NFATC3 0.017 0.006 -10000 0 -10000 0 0
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
Calcineurin A alpha-beta B1/CABIN1 0.003 0.094 -10000 0 -0.37 14 14
Exportin 1/Ran/NUP214 0.035 0.018 -10000 0 -0.3 1 1
mol:DAG 0 0.001 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV 0.021 0.09 -10000 0 -0.42 9 9
BCL2/BAX -0.071 0.16 -10000 0 -0.37 115 115
CaM/Ca2+/Calcineurin A alpha-beta B1 0.015 0.003 -10000 0 -10000 0 0
CaM/Ca2+ 0.015 0.003 -10000 0 -10000 0 0
BAX 0.016 0.02 -10000 0 -0.25 3 3
MAPK14 0.018 0.012 -10000 0 -0.25 1 1
BAD 0.017 0.023 -10000 0 -0.52 1 1
CABIN1/MEF2D 0.012 0.09 -10000 0 -0.39 11 11
Calcineurin A alpha-beta B1/BCL2 -0.11 0.22 -10000 0 -0.47 144 144
FKBP8 0.017 0.012 -10000 0 -0.25 1 1
activation-induced cell death of T cells -0.012 0.089 0.38 11 -10000 0 11
KPNB1 0.012 0.057 -10000 0 -0.52 6 6
KPNA2 -0.001 0.084 -10000 0 -0.34 27 27
XPO1 0.018 0 -10000 0 -10000 0 0
SFN -0.015 0.12 -10000 0 -0.45 37 37
MAP3K8 -0.036 0.15 -10000 0 -0.39 70 70
NFAT4/CK1 alpha 0.011 0.074 -10000 0 -0.24 37 37
MEF2D/NFAT1/Cbp/p300 0.057 0.059 -10000 0 -0.33 3 3
CABIN1 0.003 0.095 -10000 0 -0.38 14 14
CALM1 0.018 0.001 -10000 0 -10000 0 0
RAN 0.017 0.012 -10000 0 -0.25 1 1
MAP3K1 -0.03 0.14 -10000 0 -0.42 58 58
CAMK4 0.011 0.052 -10000 0 -0.33 11 11
mol:Ca2+ 0.001 0.002 -10000 0 -10000 0 0
MAPK3 0.016 0.026 -10000 0 -0.39 2 2
YWHAH 0.013 0.048 -10000 0 -0.47 5 5
Calcineurin A alpha-beta B1/AKAP79/PKA -0.01 0.11 -10000 0 -0.37 39 39
YWHAB 0.015 0.037 -10000 0 -0.39 4 4
MAPK8 0.015 0.041 -10000 0 -0.52 3 3
MAPK9 -0.006 0.11 -10000 0 -0.51 24 24
YWHAG 0.017 0.017 -10000 0 -0.25 2 2
FKBP1A 0.017 0.017 -10000 0 -0.25 2 2
NFAT1-c-4/YWHAQ 0.051 0.067 -10000 0 -0.28 1 1
PRKCH 0.011 0.056 -10000 0 -0.42 8 8
CABIN1/Cbp/p300 0.023 0.042 -10000 0 -0.37 6 6
CASP3 0.018 0.001 -10000 0 -10000 0 0
PIM1 0.013 0.035 -10000 0 -0.25 9 9
Calcineurin A alpha-beta B1/FKBP12/FK506 0.012 0.009 -10000 0 -10000 0 0
apoptosis -0.026 0.046 -10000 0 -0.32 1 1
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.033 0.052 -10000 0 -0.33 1 1
PRKCB 0 0 -10000 0 -10000 0 0
PRKCE 0.01 0.06 -10000 0 -0.43 9 9
JNK2/NFAT4 0.013 0.062 -10000 0 -0.28 23 23
BAD/BCL-XL 0.026 0.017 -10000 0 -0.37 1 1
PRKCD 0.014 0.042 -10000 0 -0.45 4 4
NUP214 0.016 0.026 -10000 0 -0.39 2 2
PRKCZ 0 0.001 -10000 0 -10000 0 0
PRKCA 0.014 0.033 -10000 0 -0.25 8 8
PRKCG 0.018 0 -10000 0 -10000 0 0
PRKCQ -0.014 0.1 -10000 0 -0.31 51 51
FKBP38/BCL2 -0.07 0.16 -10000 0 -0.37 115 115
EP300 0.014 0.047 -10000 0 -0.52 4 4
PRKCB1 -0.052 0.16 -10000 0 -0.39 90 90
CSNK2A1 0.017 0.023 -10000 0 -0.52 1 1
NFATc/JNK1 0.041 0.073 -10000 0 -10000 0 0
CaM/Ca2+/FKBP38 0.025 0.007 -10000 0 -10000 0 0
FKBP12/FK506 0.012 0.011 -10000 0 -0.17 2 2
CSNK1A1 0.022 0.015 -10000 0 -0.31 1 1
CaM/Ca2+/CAMK IV 0.021 0.032 -10000 0 -0.31 3 3
NFATc/ERK1 0.041 0.073 -10000 0 -0.49 1 1
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV 0.019 0.091 -10000 0 -0.42 10 10
NR4A1 0.052 0.066 -10000 0 -0.51 2 2
GSK3B 0.018 0.001 -10000 0 -10000 0 0
positive T cell selection 0.017 0.006 -10000 0 -10000 0 0
NFAT1/CK1 alpha 0.027 0.036 -10000 0 -0.25 2 2
RCH1/ KPNB1 0.009 0.074 -10000 0 -0.38 15 15
YWHAQ 0.014 0.039 -10000 0 -0.36 5 5
PRKACA 0.018 0.001 -10000 0 -10000 0 0
AKAP5 -0.033 0.15 -10000 0 -0.42 61 61
MEF2D 0.018 0.001 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.017 0.017 -10000 0 -0.25 2 2
NFATc/p38 alpha 0.042 0.07 -10000 0 -10000 0 0
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
BCL2 -0.11 0.22 -10000 0 -0.47 144 144
Signaling events mediated by HDAC Class II

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.041 0.037 -10000 0 -0.27 7 7
HDAC3 0.018 0 -10000 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.001 0.011 -10000 0 -0.22 1 1
GATA1/HDAC4 0.026 0.017 -10000 0 -0.37 1 1
GATA1/HDAC5 0.026 0.017 -10000 0 -0.37 1 1
GATA2/HDAC5 0.008 0.068 -10000 0 -0.37 10 10
HDAC5/BCL6/BCoR 0.016 0.078 -10000 0 -0.3 28 28
HDAC9 0.011 0.045 -10000 0 -0.28 12 12
Glucocorticoid receptor/Hsp90/HDAC6 0.021 0.068 -10000 0 -0.3 21 21
HDAC4/ANKRA2 0.013 0.072 -10000 0 -0.37 18 18
HDAC5/YWHAB 0.023 0.032 -10000 0 -0.37 3 3
NPC/RanGAP1/SUMO1/Ubc9 0.023 0.013 -10000 0 -0.2 1 1
GATA2 -0.007 0.093 -10000 0 -0.31 40 40
HDAC4/RFXANK 0.025 0.019 -10000 0 -0.37 1 1
BCOR 0.009 0.07 -10000 0 -0.52 9 9
mol:GTP 0 0 -10000 0 -10000 0 0
HDAC10 0.015 0.037 -10000 0 -0.39 4 4
HDAC5 0.017 0.023 -10000 0 -0.52 1 1
GNB1/GNG2 0.021 0.043 -10000 0 -0.37 6 6
Histones 0.02 0.07 -10000 0 -0.25 29 29
ADRBK1 0.018 0 -10000 0 -10000 0 0
HDAC4 0.017 0.023 -10000 0 -0.52 1 1
XPO1 0.018 0 -10000 0 -10000 0 0
HDAC5/ANKRA2 0.013 0.072 -10000 0 -0.37 18 18
HDAC4/Ubc9 0.026 0.017 -10000 0 -0.37 1 1
HDAC7 0 0 -10000 0 -10000 0 0
HDAC5/14-3-3 E 0.024 0.027 -10000 0 -0.37 2 2
TUBA1B 0.018 0 -10000 0 -10000 0 0
HDAC6 0.018 0 -10000 0 -10000 0 0
HDAC5/RFXANK 0.025 0.019 -10000 0 -0.37 1 1
CAMK4 0.011 0.052 -10000 0 -0.33 11 11
Tubulin/HDAC6 0.022 0.063 -10000 0 -0.3 17 17
SUMO1 0.018 0 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
YWHAB 0.015 0.037 -10000 0 -0.39 4 4
GATA1 0.018 0 -10000 0 -10000 0 0
EntrezGene:8021 0 0 -10000 0 -10000 0 0
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
NR3C1 -0.001 0.098 -10000 0 -0.51 19 19
SUMO1/HDAC4 0.036 0.019 -10000 0 -0.31 1 1
SRF 0.016 0.024 -10000 0 -0.25 4 4
HDAC4/YWHAB 0.023 0.032 -10000 0 -0.37 3 3
Tubulin 0.011 0.073 -10000 0 -0.37 17 17
HDAC4/14-3-3 E 0.024 0.03 -10000 0 -0.44 2 2
GNB1 0.013 0.052 -10000 0 -0.52 5 5
RANGAP1 0.014 0.037 -10000 0 -0.29 7 7
BCL6/BCoR 0.004 0.089 -10000 0 -0.37 27 27
HDAC4/HDAC3/SMRT (N-CoR2) 0.035 0.015 -10000 0 -0.3 1 1
HDAC4/SRF 0.03 0.037 -10000 0 -0.3 4 4
HDAC4/ER alpha -0.1 0.18 -10000 0 -0.37 151 151
EntrezGene:23225 0 0 -10000 0 -10000 0 0
positive regulation of chromatin silencing 0.02 0.069 -10000 0 -0.25 29 29
cell motility 0.022 0.063 -10000 0 -0.3 17 17
EntrezGene:23636 0 0 -10000 0 -10000 0 0
UBE2I 0.018 0 -10000 0 -10000 0 0
HDAC7/HDAC3 0.013 0 -10000 0 -10000 0 0
BCL6 -0.004 0.1 -10000 0 -0.45 24 24
HDAC4/CaMK II delta B 0.017 0.023 -10000 0 -0.52 1 1
Hsp90/HDAC6 0.023 0.033 -10000 0 -0.37 3 3
ESR1 -0.16 0.24 -10000 0 -0.46 199 199
HDAC6/HDAC11 0.004 0.089 -10000 0 -0.37 28 28
Ran/GTP/Exportin 1 0.039 0.013 -10000 0 -10000 0 0
NPC 0.01 0.008 -10000 0 -10000 0 0
MEF2C -0.014 0.12 -10000 0 -0.45 36 36
RAN 0.017 0.012 -10000 0 -0.25 1 1
HDAC4/MEF2C 0.035 0.069 -10000 0 -0.24 28 28
GNG2 0.016 0.029 -10000 0 -0.34 3 3
NCOR2 0.018 0 -10000 0 -10000 0 0
TUBB2A -0.004 0.1 -10000 0 -0.43 26 26
HDAC11 -0.012 0.12 -10000 0 -0.5 31 31
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
RANBP2 0.017 0.017 -10000 0 -0.25 2 2
ANKRA2 0 0.095 -10000 0 -0.52 17 17
RFXANK 0.017 0.012 -10000 0 -0.25 1 1
nuclear import -0.032 0.035 0.31 5 -10000 0 5
Paxillin-dependent events mediated by a4b1

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.014 0.047 -10000 0 -0.52 4 4
Rac1/GDP 0.003 0.012 -10000 0 -10000 0 0
DOCK1 0.006 0.078 -10000 0 -0.5 12 12
ITGA4 -0.007 0.1 -10000 0 -0.39 32 32
RAC1 0.018 0 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.009 0.074 -10000 0 -0.37 16 16
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.016 0.033 -10000 0 -0.52 2 2
alpha4/beta1 Integrin 0.019 0.073 -10000 0 -0.34 17 17
alpha4/beta7 Integrin/Paxillin 0.028 0.058 -10000 0 -0.27 16 16
lamellipodium assembly 0.028 0.091 -10000 0 -0.35 22 22
PIK3CA 0.016 0.029 -10000 0 -0.34 3 3
PI3K 0.005 0.082 -10000 0 -0.37 21 21
ARF6 0.016 0.033 -10000 0 -0.52 2 2
TLN1 0.017 0.023 -10000 0 -0.52 1 1
PXN 0.025 0 -10000 0 -10000 0 0
PIK3R1 -0.009 0.11 -10000 0 -0.42 33 33
ARF6/GTP 0.031 0.061 -10000 0 -0.47 2 2
cell adhesion 0.033 0.064 -10000 0 -0.27 18 18
CRKL/CBL 0.023 0.035 -10000 0 -0.37 4 4
alpha4/beta1 Integrin/Paxillin 0.026 0.067 -10000 0 -0.3 17 17
ITGB1 0.014 0.044 -10000 0 -0.41 5 5
ITGB7 0.018 0 -10000 0 -10000 0 0
ARF6/GDP 0.001 0.034 -10000 0 -0.51 2 2
alpha4/beta1 Integrin/Paxillin/VCAM1 0.015 0.1 -10000 0 -0.3 40 40
p130Cas/Crk/Dock1 0.027 0.054 -10000 0 -0.3 13 13
VCAM1 -0.022 0.13 -10000 0 -0.42 48 48
alpha4/beta1 Integrin/Paxillin/Talin 0.035 0.065 -10000 0 -0.28 18 18
alpha4/beta1 Integrin/Paxillin/GIT1 0.034 0.066 -10000 0 -0.28 18 18
BCAR1 0.017 0.012 -10000 0 -0.25 1 1
mol:GDP -0.032 0.065 0.27 18 -10000 0 18
CBL 0.017 0.012 -10000 0 -0.25 1 1
PRKACA 0.018 0 -10000 0 -10000 0 0
GIT1 0.014 0.035 -10000 0 -0.3 6 6
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.035 0.065 -10000 0 -0.28 18 18
Rac1/GTP -0.019 0.087 -10000 0 -0.38 22 22
Nephrin/Neph1 signaling in the kidney podocyte

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity -0.009 0.07 0.39 11 -10000 0 11
KIRREL 0.007 0.075 -10000 0 -0.53 10 10
Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.01 0.07 -10000 0 -0.39 11 11
PLCG1 0.016 0.026 -10000 0 -0.39 2 2
ARRB2 0.018 0 -10000 0 -10000 0 0
WASL 0.01 0.066 -10000 0 -0.52 8 8
Nephrin/NEPH1/podocin/CD2AP 0.028 0.059 -10000 0 -0.27 14 14
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.025 0.06 -10000 0 -0.25 14 14
FYN 0.014 0.059 -10000 0 -0.25 20 20
mol:Ca2+ 0.027 0.06 -10000 0 -0.29 13 13
mol:DAG 0.028 0.06 -10000 0 -0.29 13 13
NPHS2 0.015 0.036 -10000 0 -0.43 3 3
mol:IP3 0.028 0.06 -10000 0 -0.29 13 13
regulation of endocytosis 0.028 0.058 -10000 0 -0.25 13 13
Nephrin/NEPH1/podocin/Cholesterol 0.018 0.056 -10000 0 -0.28 13 13
establishment of cell polarity 0.009 0.07 -10000 0 -0.39 11 11
Nephrin/NEPH1/podocin/NCK1-2 0.035 0.06 -10000 0 -0.25 14 14
Nephrin/NEPH1/beta Arrestin2 0.029 0.059 -10000 0 -0.26 13 13
NPHS1 0.004 0.061 -10000 0 -0.26 25 25
Nephrin/NEPH1/podocin 0.02 0.061 -10000 0 -0.25 20 20
TJP1 0.013 0.052 -10000 0 -0.52 5 5
NCK1 0.011 0.045 -10000 0 -0.28 12 12
NCK2 0.015 0.026 -10000 0 -0.25 5 5
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.061 -10000 0 -0.3 13 13
CD2AP 0.016 0.029 -10000 0 -0.34 3 3
Nephrin/NEPH1/podocin/GRB2 0.028 0.058 -10000 0 -0.27 13 13
GRB2 0.016 0.024 -10000 0 -0.25 4 4
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 0.012 0.068 -10000 0 -0.27 24 24
cytoskeleton organization 0.029 0.063 -10000 0 -0.27 14 14
Nephrin/NEPH1 0.011 0.049 -10000 0 -0.27 11 11
Nephrin/NEPH1/ZO-1 0.019 0.066 -10000 0 -0.31 16 16
Aurora C signaling

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.002 0.081 -9999 0 -0.36 22 22
Aurora C/Aurora B/INCENP 0.016 0.061 -9999 0 -0.28 14 14
metaphase 0 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
H3F3B -0.007 0.037 -9999 0 -0.52 2 2
AURKB 0.009 0.056 -9999 0 -0.31 14 14
AURKC 0.008 0.053 -9999 0 -0.27 18 18
FoxO family signaling

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.04 0.082 -9999 0 -1.3 1 1
PLK1 0.03 0.18 -9999 0 -0.68 9 9
CDKN1B 0.062 0.17 -9999 0 -0.48 31 31
FOXO3 0.022 0.19 -9999 0 -0.57 21 21
KAT2B 0.003 0.02 -9999 0 -0.048 24 24
FOXO1/SIRT1 0.035 0.067 -9999 0 -0.37 5 5
CAT 0.024 0.2 -9999 0 -0.86 12 12
CTNNB1 0.001 0.09 -9999 0 -0.45 19 19
AKT1 0.019 0.057 -9999 0 -0.36 9 9
FOXO1 0.035 0.067 -9999 0 -0.33 7 7
MAPK10 0.014 0.073 -9999 0 -0.26 27 27
mol:GTP 0.001 0.003 -9999 0 -10000 0 0
FOXO4 0.061 0.1 -9999 0 -0.4 5 5
response to oxidative stress 0.008 0.022 -9999 0 -0.049 23 23
FOXO3A/SIRT1 0.035 0.16 -9999 0 -0.49 19 19
XPO1 0.018 0.001 -9999 0 -10000 0 0
EP300 0.017 0.047 -9999 0 -0.52 4 4
BCL2L11 0.027 0.038 -9999 0 -10000 0 0
FOXO1/SKP2 0.035 0.071 -9999 0 -0.42 5 5
mol:GDP 0.008 0.022 -9999 0 -0.049 23 23
RAN 0.018 0.012 -9999 0 -0.25 1 1
GADD45A 0.038 0.22 -9999 0 -0.9 21 21
YWHAQ 0.014 0.039 -9999 0 -0.36 5 5
FOXO1/14-3-3 family 0.066 0.061 -9999 0 -0.34 2 2
MST1 0.02 0.03 -9999 0 -0.29 3 3
CSNK1D 0.018 0 -9999 0 -10000 0 0
CSNK1E 0.017 0.012 -9999 0 -0.25 1 1
FOXO4/14-3-3 family 0.04 0.081 -9999 0 -0.56 1 1
YWHAB 0.015 0.037 -9999 0 -0.39 4 4
MAPK8 0.034 0.038 -9999 0 -0.26 7 7
MAPK9 0.023 0.067 -9999 0 -0.25 27 27
YWHAG 0.017 0.017 -9999 0 -0.25 2 2
YWHAE 0.016 0.029 -9999 0 -0.34 3 3
YWHAZ 0.017 0.017 -9999 0 -0.25 2 2
SIRT1 0.018 0.035 -9999 0 -0.35 3 3
SOD2 0.066 0.17 -9999 0 -0.58 12 12
RBL2 0.046 0.16 -9999 0 -0.82 6 6
RAL/GDP 0.031 0.034 -9999 0 -0.31 4 4
CHUK 0.009 0.083 -9999 0 -0.5 13 13
Ran/GTP 0.016 0.009 -9999 0 -0.16 1 1
CSNK1G2 0.016 0.033 -9999 0 -0.52 2 2
RAL/GTP 0.036 0.035 -9999 0 -0.28 4 4
CSNK1G1 0.017 0.012 -9999 0 -0.25 1 1
FASLG -0.12 0.41 -9999 0 -1.4 49 49
SKP2 0.007 0.052 -9999 0 -0.25 20 20
USP7 0.018 0.012 -9999 0 -0.26 1 1
IKBKB 0.015 0.051 -9999 0 -0.31 10 10
CCNB1 -0.02 0.32 -9999 0 -1.1 37 37
FOXO1-3a-4/beta catenin 0.068 0.17 -9999 0 -0.41 24 24
proteasomal ubiquitin-dependent protein catabolic process 0.034 0.071 -9999 0 -0.41 5 5
CSNK1A1 0.017 0.023 -9999 0 -0.52 1 1
SGK1 0.003 0.02 -9999 0 -0.048 24 24
CSNK1G3 0.013 0.052 -9999 0 -0.52 5 5
Ran/GTP/Exportin 1 0.028 0.011 -9999 0 -10000 0 0
ZFAND5 0.067 0.09 -9999 0 -0.39 1 1
SFN -0.015 0.12 -9999 0 -0.45 37 37
CDK2 0.015 0.047 -9999 0 -0.3 10 10
FOXO3A/14-3-3 0.043 0.08 -9999 0 -0.35 7 7
CREBBP 0.019 0.033 -9999 0 -0.52 2 2
FBXO32 -0.007 0.3 -9999 0 -1.2 25 25
BCL6 0.016 0.26 -9999 0 -1.2 19 19
RALB 0.015 0.047 -9999 0 -0.52 4 4
RALA 0.019 0.002 -9999 0 -10000 0 0
YWHAH 0.013 0.048 -9999 0 -0.47 5 5
Circadian rhythm pathway

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.017 0.1 -10000 0 -1.3 1 1
CLOCK 0.02 0.024 -10000 0 -0.52 1 1
TIMELESS/CRY2 0.041 0.06 -10000 0 -1.2 1 1
DEC1/BMAL1 0.015 0.072 -10000 0 -0.39 15 15
ATR 0.017 0.012 -10000 0 -0.25 1 1
NR1D1 0.036 0.045 -10000 0 -10000 0 0
ARNTL 0.009 0.078 -10000 0 -0.49 12 12
TIMELESS 0.036 0.065 -10000 0 -1.3 1 1
NPAS2 -0.004 0.094 -10000 0 -0.32 39 39
CRY2 0.017 0.012 -10000 0 -0.25 1 1
mol:CO -0.014 0.012 0.14 1 -10000 0 1
CHEK1 -0.046 0.16 -10000 0 -0.38 84 84
mol:HEME 0.014 0.012 -10000 0 -0.14 1 1
PER1 0.014 0.037 -10000 0 -0.29 7 7
BMAL/CLOCK/NPAS2 0.03 0.082 -10000 0 -0.32 21 21
BMAL1/CLOCK 0.042 0.076 -10000 0 -0.5 3 3
S phase of mitotic cell cycle 0.017 0.1 -10000 0 -1.3 1 1
TIMELESS/CHEK1/ATR 0.017 0.1 -10000 0 -1.4 1 1
mol:NADPH 0.014 0.012 -10000 0 -0.14 1 1
PER1/TIMELESS 0.039 0.063 -10000 0 -1.2 1 1
PER1-2 / CRY1-2 0 0 -10000 0 -10000 0 0
DEC1 0.011 0.057 -10000 0 -0.4 9 9
S1P5 pathway

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.01 0.078 0.29 16 -10000 0 16
GNAI2 0.006 0.075 -10000 0 -0.48 12 12
S1P/S1P5/G12 0.012 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 0.016 0.024 -10000 0 -0.25 4 4
RhoA/GTP 0.01 0.08 -10000 0 -0.29 16 16
negative regulation of cAMP metabolic process 0.008 0.072 -10000 0 -0.29 12 12
GNAZ 0.001 0.088 -10000 0 -0.44 19 19
GNAI3 0.018 0 -10000 0 -10000 0 0
GNA12 0.018 0 -10000 0 -10000 0 0
S1PR5 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi 0.008 0.072 -10000 0 -0.29 12 12
RhoA/GDP 0.004 0.058 -10000 0 -0.38 12 12
RHOA 0.005 0.08 -10000 0 -0.52 12 12
GNAI1 -0.017 0.12 -10000 0 -0.38 46 46
Alternative NF-kappaB pathway

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.015 0.065 -9999 0 -0.37 14 14
FBXW11 0.015 0.035 -9999 0 -0.43 3 3
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.015 0.035 -9999 0 -0.43 3 3
CHUK 0.005 0.081 -9999 0 -0.5 13 13
NF kappa B2 p100/RelB 0.034 0.074 -9999 0 -0.28 24 24
NFKB1 0.017 0.023 -9999 0 -0.52 1 1
MAP3K14 0.015 0.037 -9999 0 -0.39 4 4
NF kappa B1 p50/RelB 0.015 0.059 -9999 0 -0.37 10 10
RELB 0.003 0.078 -9999 0 -0.38 19 19
NFKB2 0.015 0.031 -9999 0 -0.32 4 4
NF kappa B2 p52/RelB 0.014 0.052 -9999 0 -0.31 11 11
regulation of B cell activation 0.014 0.052 -9999 0 -0.31 11 11
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.009 0.067 -10000 0 -0.49 9 9
SMAD2 0.021 0.048 0.24 1 -0.23 9 10
SMAD3 0.032 0.056 -10000 0 -0.39 2 2
SMAD3/SMAD4 0.033 0.069 -10000 0 -0.34 9 9
SMAD4/Ubc9/PIASy 0.027 0.052 -10000 0 -0.3 12 12
SMAD2/SMAD2/SMAD4 0.031 0.061 -10000 0 -0.27 1 1
PPM1A 0.016 0.026 -10000 0 -0.39 2 2
CALM1 0.018 0 -10000 0 -10000 0 0
SMAD2/SMAD4 0.024 0.056 0.2 1 -0.23 17 18
MAP3K1 -0.03 0.14 -10000 0 -0.42 58 58
TRAP-1/SMAD4 0.02 0.049 -10000 0 -0.37 8 8
MAPK3 0.016 0.026 -10000 0 -0.39 2 2
MAPK1 0.016 0.033 -10000 0 -0.52 2 2
NUP214 0.016 0.026 -10000 0 -0.39 2 2
CTDSP1 0.016 0.033 -10000 0 -0.52 2 2
CTDSP2 0.014 0.044 -10000 0 -0.41 5 5
CTDSPL 0.011 0.062 -10000 0 -0.52 7 7
KPNB1 0.012 0.057 -10000 0 -0.52 6 6
TGFBRAP1 0.017 0.012 -10000 0 -0.25 1 1
UBE2I 0.018 0 -10000 0 -10000 0 0
NUP153 0.016 0.024 -10000 0 -0.25 4 4
KPNA2 -0.001 0.084 -10000 0 -0.34 27 27
PIAS4 0.013 0.049 -10000 0 -0.43 6 6
Canonical NF-kappaB pathway

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.018 0.036 -9999 0 -0.43 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.06 0.078 -9999 0 -0.38 4 4
ERC1 0.011 0.056 -9999 0 -0.42 8 8
RIP2/NOD2 -0.031 0.13 -9999 0 -0.37 66 66
NFKBIA 0.042 0.051 -9999 0 -0.54 3 3
BIRC2 0.016 0.02 -9999 0 -0.25 3 3
IKBKB 0.012 0.047 -9999 0 -0.31 10 10
RIPK2 0.013 0.04 -9999 0 -0.28 9 9
IKBKG 0.016 0.091 -9999 0 -0.51 5 5
IKK complex/A20 0.027 0.1 -9999 0 -0.44 9 9
NEMO/A20/RIP2 0.013 0.04 -9999 0 -0.28 9 9
XPO1 0.018 0 -9999 0 -10000 0 0
NEMO/ATM 0.024 0.088 -9999 0 -0.48 5 5
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
RAN 0.017 0.012 -9999 0 -0.25 1 1
Exportin 1/RanGTP 0.024 0.007 -9999 0 -10000 0 0
IKK complex/ELKS -0.028 0.077 -9999 0 -0.46 8 8
BCL10/MALT1/TRAF6 0.031 0.041 -9999 0 -0.38 4 4
NOD2 -0.056 0.18 -9999 0 -0.46 81 81
NFKB1 0.019 0.025 -9999 0 -0.52 1 1
RELA 0.02 0.009 -9999 0 -10000 0 0
MALT1 0.011 0.053 -9999 0 -0.37 9 9
cIAP1/UbcH5C 0.025 0.014 -9999 0 -10000 0 0
ATM 0.017 0.012 -9999 0 -0.25 1 1
TNF/TNFR1A 0.009 0.071 -9999 0 -0.37 14 14
TRAF6 0.017 0.023 -9999 0 -0.52 1 1
PRKCA 0.014 0.033 -9999 0 -0.25 8 8
CHUK 0.005 0.081 -9999 0 -0.5 13 13
UBE2D3 0.018 0 -9999 0 -10000 0 0
TNF -0.004 0.094 -9999 0 -0.36 31 31
NF kappa B1 p50/RelA 0.045 0.036 -9999 0 -0.28 6 6
BCL10 0.017 0.012 -9999 0 -0.25 1 1
proteasomal ubiquitin-dependent protein catabolic process 0.042 0.051 -9999 0 -0.54 3 3
beta TrCP1/SCF ubiquitin ligase complex 0.018 0.036 -9999 0 -0.42 3 3
TNFRSF1A 0.016 0.033 -9999 0 -0.52 2 2
IKK complex 0.025 0.1 -9999 0 -0.46 9 9
CYLD 0.014 0.044 -9999 0 -0.41 5 5
IKK complex/PKC alpha 0.03 0.1 -9999 0 -0.49 7 7
Ephrin A reverse signaling

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade 0.015 0.047 -9999 0 -0.31 8 8
EFNA5 0.006 0.068 -9999 0 -0.35 17 17
FYN 0.015 0.055 -9999 0 -0.28 15 15
neuron projection morphogenesis 0.015 0.047 -9999 0 -0.31 8 8
cell-cell signaling 0 0 -9999 0 -10000 0 0
Ephrin A5/EPHA5 0.015 0.047 -9999 0 -0.31 8 8
EPHA5 0.015 0.037 -9999 0 -0.39 4 4
Class I PI3K signaling events mediated by Akt

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.025 0 -10000 0 -10000 0 0
BAD/BCL-XL/YWHAZ 0.04 0.016 -10000 0 -0.27 1 1
CDKN1B 0.021 0.079 -10000 0 -0.37 8 8
CDKN1A 0.025 0.072 -10000 0 -0.44 6 6
FRAP1 0.018 0 -10000 0 -10000 0 0
PRKDC 0.012 0.045 -10000 0 -0.31 9 9
FOXO3 0.033 0.062 -10000 0 -0.46 6 6
AKT1 0.03 0.053 -10000 0 -0.43 6 6
BAD 0.017 0.023 -10000 0 -0.52 1 1
AKT3 0.007 0.046 -10000 0 -0.32 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 0.035 0.053 -10000 0 -0.39 7 7
AKT1/ASK1 0.018 0.081 -10000 0 -0.36 10 10
BAD/YWHAZ 0.035 0.018 -10000 0 -0.3 1 1
RICTOR 0.018 0 -10000 0 -10000 0 0
RAF1 0.017 0.012 -10000 0 -0.25 1 1
JNK cascade -0.017 0.079 0.35 10 -10000 0 10
TSC1 0.036 0.051 -10000 0 -0.4 6 6
YWHAZ 0.017 0.017 -10000 0 -0.25 2 2
AKT1/RAF1 0.038 0.052 -10000 0 -0.4 6 6
EP300 0.014 0.047 -10000 0 -0.52 4 4
mol:GDP 0.03 0.053 -10000 0 -0.42 6 6
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 0.035 0.056 -10000 0 -0.44 6 6
YWHAQ 0.014 0.039 -10000 0 -0.36 5 5
TBC1D4 0.011 0.063 -10000 0 -0.3 19 19
MAP3K5 -0.022 0.13 -10000 0 -0.42 47 47
MAPKAP1 0.016 0.026 -10000 0 -0.39 2 2
negative regulation of cell cycle -0.034 0.048 0.24 3 -10000 0 3
YWHAH 0.013 0.048 -10000 0 -0.47 5 5
AKT1S1 0.032 0.063 -10000 0 -0.4 9 9
CASP9 0.035 0.053 -10000 0 -0.39 7 7
YWHAB 0.015 0.037 -10000 0 -0.39 4 4
p27Kip1/KPNA1 0.03 0.076 -10000 0 -0.36 7 7
GBL 0.015 0.035 -10000 0 -0.43 3 3
PDK1/Src/Hsp90 0.031 0.039 -10000 0 -0.3 6 6
YWHAE 0.016 0.029 -10000 0 -0.34 3 3
SRC 0.015 0.035 -10000 0 -0.43 3 3
AKT2/p21CIP1 0.03 0.068 -10000 0 -0.39 6 6
KIAA1303 0.015 0.031 -10000 0 -0.32 4 4
mTOR/RHEB/GTP/Raptor/GBL 0.038 0.041 -10000 0 -0.39 4 4
CHUK 0.03 0.068 -10000 0 -0.42 7 7
BAD/BCL-XL 0.052 0.051 -10000 0 -0.37 6 6
mTORC2 0.043 0.025 -10000 0 -0.27 3 3
AKT2 0.019 0.017 -10000 0 -0.32 1 1
FOXO1-3a-4/14-3-3 family 0.046 0.064 -10000 0 -0.29 4 4
PDPK1 0.016 0.026 -10000 0 -0.39 2 2
MDM2 0.033 0.054 -10000 0 -0.4 6 6
MAPKKK cascade -0.038 0.051 0.39 6 -10000 0 6
MDM2/Cbp/p300 0.047 0.061 -10000 0 -0.4 6 6
TSC1/TSC2 0.041 0.055 -10000 0 -0.42 6 6
proteasomal ubiquitin-dependent protein catabolic process 0.045 0.058 -10000 0 -0.38 6 6
glucose import 0.011 0.064 -10000 0 -0.26 21 21
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.044 0.053 -10000 0 -0.41 4 4
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 0.011 0.064 -10000 0 -0.26 21 21
GSK3A 0.036 0.051 -10000 0 -0.4 6 6
FOXO1 0.027 0.068 -10000 0 -0.39 7 7
GSK3B 0.036 0.051 -10000 0 -0.4 6 6
SFN -0.015 0.12 -10000 0 -0.45 37 37
G1/S transition of mitotic cell cycle 0.042 0.05 -10000 0 -0.38 6 6
p27Kip1/14-3-3 family 0.034 0.063 -10000 0 -0.37 4 4
PRKACA 0.018 0 -10000 0 -10000 0 0
KPNA1 0.018 0 -10000 0 -10000 0 0
HSP90AA1 0.013 0.045 -10000 0 -0.39 6 6
YWHAG 0.017 0.017 -10000 0 -0.25 2 2
RHEB 0.016 0.026 -10000 0 -0.39 2 2
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
Arf6 trafficking events

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 0.005 0.06 -10000 0 -0.26 24 24
CLTC 0.025 0.05 -10000 0 -0.49 3 3
calcium ion-dependent exocytosis 0.021 0.039 -10000 0 -0.28 4 4
Dynamin 2/GTP 0.025 0.027 -10000 0 -0.28 2 2
EXOC4 0.016 0.033 -10000 0 -0.52 2 2
CD59 0.021 0.05 -10000 0 -0.42 4 4
CPE -0.021 0.11 -10000 0 -0.32 53 53
CTNNB1 0.001 0.09 -10000 0 -0.45 19 19
membrane fusion 0.021 0.041 -10000 0 -0.39 2 2
CTNND1 0.029 0.029 -10000 0 -0.25 3 3
DNM2 0.017 0.012 -10000 0 -0.25 1 1
mol:PI-4-5-P2 0.027 0.039 -10000 0 -0.35 3 3
TSHR 0.014 0.048 -10000 0 -0.31 11 11
INS 0.02 0.026 -10000 0 -0.51 1 1
BIN1 0.014 0.04 -10000 0 -0.34 6 6
mol:Choline 0.021 0.041 -10000 0 -0.39 2 2
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.017 0.03 -10000 0 -0.31 2 2
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.016 0.033 -10000 0 -0.52 2 2
mol:Ca2+ 0.025 0.027 -10000 0 -0.27 2 2
JUP 0.023 0.046 -10000 0 -0.48 3 3
ASAP2/amphiphysin II 0.019 0.029 -10000 0 -0.28 4 4
ARF6/GTP 0.012 0.024 -10000 0 -0.38 2 2
CDH1 0 0.078 -10000 0 -0.46 3 3
clathrin-independent pinocytosis 0.012 0.024 -10000 0 -0.38 2 2
MAPK8IP3 0.006 0.075 -10000 0 -0.48 12 12
positive regulation of endocytosis 0.012 0.024 -10000 0 -0.38 2 2
EXOC2 -0.004 0.085 -10000 0 -0.31 35 35
substrate adhesion-dependent cell spreading 0.023 0.078 -10000 0 -0.24 37 37
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.014 0.035 -10000 0 -0.3 6 6
regulation of calcium-dependent cell-cell adhesion -0.011 0.077 0.44 4 -10000 0 4
positive regulation of phagocytosis 0.018 0.032 -10000 0 -0.31 5 5
ARF6/GTP/JIP3 0.016 0.051 -10000 0 -0.31 12 12
ACAP1 0.019 0.035 -10000 0 -0.35 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 0.016 0.046 -10000 0 -0.52 2 2
clathrin heavy chain/ACAP1 0.028 0.048 -10000 0 -0.46 3 3
JIP4/KLC1 0.031 0.027 -10000 0 -0.28 3 3
EXOC1 0.018 0 -10000 0 -10000 0 0
exocyst 0.023 0.078 -10000 0 -0.25 37 37
RALA/GTP 0.013 0 -10000 0 -10000 0 0
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.021 0.029 -10000 0 -0.31 3 3
receptor recycling 0.012 0.024 -10000 0 -0.38 2 2
CTNNA1 0.03 0.028 -10000 0 -0.25 3 3
NME1 0.017 0.03 -10000 0 -0.31 2 2
clathrin coat assembly 0.025 0.05 -10000 0 -0.48 3 3
IL2RA 0.008 0.069 -10000 0 -0.35 7 7
VAMP3 0.018 0.032 -10000 0 -0.31 5 5
GLUT4/clathrin heavy chain/ACAP1 -0.008 0.04 -10000 0 -0.43 3 3
EXOC6 -0.012 0.12 -10000 0 -0.5 30 30
PLD1 0.015 0.05 -10000 0 -0.29 11 11
PLD2 0.021 0.033 -10000 0 -0.26 6 6
EXOC5 0.016 0.033 -10000 0 -0.52 2 2
PIP5K1C 0.028 0.039 -10000 0 -0.35 3 3
SDC1 0.004 0.072 -10000 0 -0.39 4 4
ARF6/GDP 0.018 0.03 -10000 0 -0.31 2 2
EXOC7 0.018 0 -10000 0 -10000 0 0
E-cadherin/beta catenin 0.013 0.079 -10000 0 -0.52 3 3
mol:Phosphatidic acid 0.021 0.041 -10000 0 -0.39 2 2
endocytosis -0.019 0.029 0.28 4 -10000 0 4
SCAMP2 0.015 0.035 -10000 0 -0.43 3 3
ADRB2 0.001 0.096 -10000 0 -0.45 8 8
EXOC3 0.017 0.012 -10000 0 -0.25 1 1
ASAP2 0 0 -10000 0 -10000 0 0
Dynamin 2/GDP 0.027 0.028 -10000 0 -0.27 2 2
KLC1 0.018 0 -10000 0 -10000 0 0
AVPR2 0.03 0.049 -10000 0 -0.45 3 3
RALA 0.018 0 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.022 0.076 -10000 0 -0.58 2 2
S1P4 pathway

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
GNAO1 0.016 0.024 -9999 0 -0.25 4 4
CDC42/GTP 0.016 0.067 -9999 0 -0.33 5 5
PLCG1 0.014 0.07 -9999 0 -0.26 13 13
mol:GTP 0 0 -9999 0 -10000 0 0
GNAI2 0.006 0.075 -9999 0 -0.48 12 12
GNAI3 0.018 0 -9999 0 -10000 0 0
G12/G13 0.021 0.039 -9999 0 -0.37 4 4
cell migration 0.016 0.065 -9999 0 -0.32 5 5
S1PR5 0 0 -9999 0 -10000 0 0
S1PR4 0 0 -9999 0 -10000 0 0
MAPK3 0.014 0.069 -9999 0 -0.32 6 6
MAPK1 0.014 0.07 -9999 0 -0.31 7 7
S1P/S1P5/Gi 0.008 0.072 -9999 0 -0.29 12 12
GNAI1 -0.017 0.12 -9999 0 -0.38 46 46
CDC42/GDP 0.013 0 -9999 0 -10000 0 0
S1P/S1P5/G12 0.012 0 -9999 0 -10000 0 0
RHOA 0.017 0.056 -9999 0 -0.3 14 14
S1P/S1P4/Gi 0.008 0.072 -9999 0 -0.29 12 12
mol:GDP 0 0 -9999 0 -10000 0 0
GNAZ 0.001 0.088 -9999 0 -0.44 19 19
S1P/S1P4/G12/G13 0.019 0.03 -9999 0 -0.28 4 4
GNA12 0.018 0 -9999 0 -10000 0 0
GNA13 0.011 0.055 -9999 0 -0.36 10 10
CDC42 0.018 0 -9999 0 -10000 0 0
Insulin-mediated glucose transport

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles 0.038 0.06 -9999 0 -0.35 4 4
CaM/Ca2+ 0.013 0 -9999 0 -10000 0 0
AKT1 0.011 0.053 -9999 0 -0.37 9 9
AKT2 0.017 0.012 -9999 0 -0.25 1 1
STXBP4 0.008 0.06 -9999 0 -0.32 15 15
mol:GTP 0 0 -9999 0 -10000 0 0
mol:glucose 0.033 0.053 -9999 0 -0.26 3 3
YWHAZ 0.017 0.017 -9999 0 -0.25 2 2
CALM1 0.018 0 -9999 0 -10000 0 0
YWHAQ 0.014 0.039 -9999 0 -0.36 5 5
TBC1D4 0.004 0.086 -9999 0 -0.38 21 21
mol:Ca2+ 0 0 -9999 0 -10000 0 0
YWHAH 0.013 0.048 -9999 0 -0.47 5 5
YWHAB 0.015 0.037 -9999 0 -0.39 4 4
SNARE/Synip 0.029 0.042 -9999 0 -0.3 6 6
YWHAG 0.017 0.017 -9999 0 -0.25 2 2
ASIP 0 0 -9999 0 -10000 0 0
PRKCI 0.002 0.085 -9999 0 -0.43 18 18
AS160/CaM/Ca2+ 0.013 0 -9999 0 -10000 0 0
RHOQ 0.012 0.053 -9999 0 -0.48 6 6
GYS1 0.031 0.027 -9999 0 -0.26 4 4
PRKCZ 0 0 -9999 0 -10000 0 0
TRIP10 0.013 0.048 -9999 0 -0.47 5 5
TC10/GTP/CIP4/Exocyst 0.018 0.045 -9999 0 -0.31 9 9
AS160/14-3-3 0.025 0.066 -9999 0 -0.39 1 1
VAMP2 0.017 0.023 -9999 0 -0.52 1 1
SLC2A4 0.033 0.056 -9999 0 -0.28 3 3
STX4 0.017 0.023 -9999 0 -0.52 1 1
GSK3B 0.026 0.032 -9999 0 -0.31 4 4
SFN -0.015 0.12 -9999 0 -0.45 37 37
LNPEP 0.01 0.06 -9999 0 -0.43 9 9
YWHAE 0.016 0.029 -9999 0 -0.34 3 3
Signaling events mediated by HDAC Class I

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0.033 0.064 -10000 0 -0.29 16 16
Ran/GTP/Exportin 1/HDAC1 -0.001 0.011 -10000 0 -0.22 1 1
NF kappa B1 p50/RelA/I kappa B alpha 0.039 0.064 -10000 0 -0.27 14 14
SUMO1 0.018 0 -10000 0 -10000 0 0
ZFPM1 0.009 0.068 -10000 0 -0.47 10 10
NPC/RanGAP1/SUMO1/Ubc9 0.023 0.013 -10000 0 -0.2 1 1
FKBP3 0.013 0.048 -10000 0 -0.47 5 5
Histones 0.043 0.05 -10000 0 -0.28 2 2
YY1/LSF 0.02 0.056 -10000 0 -0.26 20 20
SMG5 0.016 0.029 -10000 0 -0.34 3 3
RAN 0.017 0.012 -10000 0 -0.25 1 1
I kappa B alpha/HDAC3 0.025 0.056 -10000 0 -0.24 19 19
I kappa B alpha/HDAC1 0.027 0.051 -10000 0 -0.31 6 6
SAP18 0.018 0 -10000 0 -10000 0 0
RELA 0.03 0.051 -10000 0 -10000 0 0
HDAC1/Smad7 0.035 0.022 -10000 0 -0.3 2 2
RANGAP1 0.014 0.037 -10000 0 -0.29 7 7
HDAC3/TR2 0.026 0.053 -10000 0 -0.28 9 9
NuRD/MBD3 Complex 0.045 0.038 -10000 0 -0.27 2 2
NF kappa B1 p50/RelA 0.035 0.049 -10000 0 -0.24 1 1
EntrezGene:23225 0 0 -10000 0 -10000 0 0
GATA2 -0.007 0.093 -10000 0 -0.31 40 40
GATA1 0.018 0 -10000 0 -10000 0 0
Mad/Max 0.024 0.021 -10000 0 -10000 0 0
NuRD/MBD3 Complex/GATA1/Fog1 0.053 0.054 -10000 0 -0.48 2 2
RBBP7 0.01 0.051 -10000 0 -0.3 13 13
NPC 0.01 0.008 -10000 0 -10000 0 0
RBBP4 0.016 0.026 -10000 0 -0.39 2 2
MAX 0.018 0 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
FBXW11 0.015 0.035 -10000 0 -0.43 3 3
NFKBIA 0.02 0.054 -10000 0 -0.36 5 5
KAT2B 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
SIN3/HDAC complex 0.041 0.036 -10000 0 -10000 0 0
SIN3 complex 0.042 0.032 -10000 0 -0.27 5 5
SMURF1 0.018 0 -10000 0 -10000 0 0
CHD3 0.015 0.037 -10000 0 -0.39 4 4
SAP30 0.012 0.053 -10000 0 -0.48 6 6
EntrezGene:23636 0 0 -10000 0 -10000 0 0
NCOR1 0.016 0.033 -10000 0 -0.52 2 2
YY1/HDAC3 0.032 0.046 -10000 0 -0.29 2 2
YY1/HDAC2 0.022 0.045 -10000 0 -0.25 11 11
YY1/HDAC1 0.027 0.036 -10000 0 -0.23 10 10
NuRD/MBD2 Complex (MeCP1) 0.044 0.038 -10000 0 -0.27 2 2
PPARG 0.006 0.096 -10000 0 -0.3 38 38
HDAC8/hEST1B 0.034 0.027 -10000 0 -0.3 3 3
UBE2I 0.018 0 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.015 0.035 -10000 0 -0.43 3 3
TNFRSF1A 0.016 0.033 -10000 0 -0.52 2 2
HDAC3/SMRT (N-CoR2) 0.03 0.041 -10000 0 -0.32 2 2
MBD3L2 0.007 0.072 -10000 0 -0.45 12 12
ubiquitin-dependent protein catabolic process 0.034 0.022 -10000 0 -0.3 2 2
CREBBP 0.016 0.033 -10000 0 -0.52 2 2
NuRD/MBD3/MBD3L2 Complex 0.049 0.051 -10000 0 -0.32 2 2
HDAC1 0.017 0.023 -10000 0 -0.52 1 1
HDAC3 0.023 0.045 -10000 0 -0.36 2 2
HDAC2 0.009 0.053 -10000 0 -0.29 15 15
YY1 0.021 0.038 -10000 0 -0.27 9 9
HDAC8 0.016 0.033 -10000 0 -0.52 2 2
SMAD7 0.016 0.026 -10000 0 -0.39 2 2
NCOR2 0.018 0 -10000 0 -10000 0 0
MXD1 0.014 0.031 -10000 0 -0.25 7 7
STAT3 0.024 0.044 -10000 0 -0.31 9 9
NFKB1 0.017 0.023 -10000 0 -0.52 1 1
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 0.017 0.017 -10000 0 -0.25 2 2
YY1/LSF/HDAC1 0.03 0.054 -10000 0 -0.26 12 12
YY1/SAP30/HDAC1 0.033 0.047 -10000 0 -0.3 6 6
EP300 0.014 0.047 -10000 0 -0.52 4 4
STAT3 (dimer non-phopshorylated) 0.024 0.044 -10000 0 -0.31 9 9
proteasomal ubiquitin-dependent protein catabolic process 0.02 0.054 -10000 0 -0.36 5 5
histone deacetylation 0.044 0.038 -10000 0 -0.27 2 2
STAT3 (dimer non-phopshorylated)/HDAC3 0.035 0.051 -10000 0 -0.32 3 3
nuclear export -0.033 0.027 0.3 3 -10000 0 3
PRKACA 0.018 0 -10000 0 -10000 0 0
GATAD2B 0.017 0.023 -10000 0 -0.52 1 1
GATAD2A 0.014 0.037 -10000 0 -0.29 7 7
GATA2/HDAC3 0.017 0.069 -10000 0 -0.32 12 12
GATA1/HDAC1 0.026 0.017 -10000 0 -0.37 1 1
GATA1/HDAC3 0.03 0.041 -10000 0 -0.32 2 2
CHD4 0.017 0.023 -10000 0 -0.52 1 1
TNF-alpha/TNFR1A 0.009 0.071 -10000 0 -0.37 14 14
SIN3/HDAC complex/Mad/Max 0.046 0.033 -10000 0 -10000 0 0
NuRD Complex 0.052 0.044 -10000 0 -0.32 2 2
positive regulation of chromatin silencing 0.04 0.049 -10000 0 -0.27 2 2
SIN3B 0.017 0.012 -10000 0 -0.25 1 1
MTA2 0.014 0.044 -10000 0 -0.41 5 5
SIN3A 0.018 0 -10000 0 -10000 0 0
XPO1 0.018 0 -10000 0 -10000 0 0
SUMO1/HDAC1 0.036 0.018 -10000 0 -0.24 1 1
HDAC complex 0.035 0.045 -10000 0 -0.26 7 7
GATA1/Fog1 0.02 0.049 -10000 0 -0.37 8 8
FKBP25/HDAC1/HDAC2 0.027 0.047 -10000 0 -0.3 8 8
TNF -0.004 0.094 -10000 0 -0.36 31 31
negative regulation of cell growth 0.046 0.033 -10000 0 -10000 0 0
NuRD/MBD2/PRMT5 Complex 0.044 0.038 -10000 0 -0.27 2 2
Ran/GTP/Exportin 1 0.039 0.013 -10000 0 -10000 0 0
NF kappa B/RelA/I kappa B alpha 0.031 0.065 -10000 0 -0.29 16 16
SIN3/HDAC complex/NCoR1 0.043 0.035 -10000 0 -10000 0 0
TFCP2 0.006 0.077 -10000 0 -0.52 11 11
NR2C1 0.011 0.062 -10000 0 -0.52 7 7
MBD3 0.018 0 -10000 0 -10000 0 0
MBD2 0.017 0.017 -10000 0 -0.25 2 2
Rapid glucocorticoid signaling

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0.024 0.045 -10000 0 -0.29 8 8
MAPK9 -0.005 0.07 -10000 0 -0.33 23 23
adrenocorticotropin secretion 0.005 0.042 -10000 0 -0.2 18 18
GNB1/GNG2 0.02 0.037 -10000 0 -0.31 6 6
GNB1 0.013 0.052 -10000 0 -0.52 5 5
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 0.01 0.005 -10000 0 -10000 0 0
Gs family/GTP 0.008 0.028 -10000 0 -0.17 11 11
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.001 0.007 0.048 11 -10000 0 11
GNAL 0.011 0.052 -10000 0 -0.33 11 11
GNG2 0.016 0.029 -10000 0 -0.34 3 3
CRH 0.007 0.06 -10000 0 -0.3 18 18
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.008 0.026 -10000 0 -0.33 3 3
MAPK11 0.01 0 -10000 0 -10000 0 0
Arf1 pathway

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex 0.023 0.017 -10000 0 -0.2 2 2
EntrezGene:79658 0 0 -10000 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A 0.02 0.019 -10000 0 -0.27 1 1
AP2 0.021 0.04 -10000 0 -0.36 5 5
mol:DAG 0 0 -10000 0 -10000 0 0
Arfaptin 2/Rac/GTP 0.019 0.041 -10000 0 -0.31 8 8
CLTB 0.015 0.035 -10000 0 -0.43 3 3
coatomer protein complex/ARF1/GTP/ER cargo protein 0.027 0.02 -10000 0 -0.24 3 3
CD4 0.018 0 -10000 0 -10000 0 0
CLTA 0.018 0 -10000 0 -10000 0 0
mol:GTP 0.001 0.002 -10000 0 -10000 0 0
ARFGAP1 0.012 0.011 -10000 0 -0.17 2 2
mol:PI-4-5-P2 0.012 0.025 0.15 8 -0.18 4 12
ARF1/GTP -0.001 0.015 -10000 0 -0.29 1 1
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein 0.028 0.014 -10000 0 -0.2 1 1
mol:Choline 0.011 0.025 0.15 8 -0.19 4 12
mol:GDP 0 0 -10000 0 -10000 0 0
ARF1 0.016 0.024 -10000 0 -0.53 1 1
DDEF1 0.012 0.025 0.15 8 -0.19 4 12
ARF1/GDP 0.009 0.012 -10000 0 -10000 0 0
AP2M1 0.013 0.049 -10000 0 -0.43 6 6
EntrezGene:1313 0 0 -10000 0 -10000 0 0
actin filament polymerization 0.017 0.013 -10000 0 -0.28 1 1
Rac/GTP 0.014 0.001 -10000 0 -10000 0 0
ARF1/GTP/GGA3/ARF-GAP1 0.028 0.02 -10000 0 -0.26 2 2
ARFIP2 0.008 0.063 -10000 0 -0.47 9 9
COPA 0.018 0 -10000 0 -10000 0 0
RAC1 0.018 0 -10000 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.026 0.017 -10000 0 -0.2 2 2
ARF1/GTP/ARHGAP10 0.01 0.014 -10000 0 -0.32 1 1
GGA3 0.016 0.026 -10000 0 -0.39 2 2
ARF1/GTP/Membrin 0.017 0.015 -10000 0 -0.27 1 1
AP2A1 0.016 0.024 -10000 0 -0.25 4 4
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.028 0.021 -10000 0 -0.23 3 3
ARF1/GDP/Membrin 0.019 0.015 -10000 0 -0.26 1 1
Arfaptin 2/Rac/GDP 0.018 0.041 -10000 0 -0.31 8 8
CYTH2 0.001 0.002 -10000 0 -10000 0 0
ARF1/GTP/GGA3 0.021 0.022 -10000 0 -0.32 2 2
mol:ATP 0 0 -10000 0 -10000 0 0
Rac/GDP 0.013 0 -10000 0 -10000 0 0
mol:Brefeldin A 0 0 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.036 0.036 -10000 0 -0.36 3 3
PLD2 0.011 0.026 0.15 8 -0.19 4 12
ARF-GAP1/v-SNARE 0.012 0.011 -10000 0 -0.17 2 2
PIP5K1A 0.012 0.025 0.15 8 -0.18 4 12
ARF1/GTP/Membrin/GBF1/p115 0.018 0.016 -10000 0 -0.26 1 1
mol:Phosphatic acid 0 0 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.011 0.025 0.15 8 -0.19 4 12
KDEL Receptor/Ligand/ARF-GAP1 0.012 0.011 -10000 0 -0.17 2 2
GOSR2 0.015 0.014 -10000 0 -10000 0 0
USO1 0.015 0.013 -10000 0 -10000 0 0
GBF1 0.014 0.023 -10000 0 -0.41 1 1
ARF1/GTP/Arfaptin 2 0.018 0.044 -10000 0 -0.31 9 9
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0.032 0.035 -10000 0 -0.3 5 5
Sumoylation by RanBP2 regulates transcriptional repression

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0.023 -9999 0 -0.52 1 1
Ran/GTP/Exportin 1/HDAC4 -0.001 0.012 -9999 0 -0.25 1 1
MDM2/SUMO1 0.033 0.024 -9999 0 -10000 0 0
HDAC4 0.017 0.023 -9999 0 -0.52 1 1
Ran/GTP/Exportin 1/HDAC1 -0.001 0.011 -9999 0 -0.2 1 1
SUMO1 0.018 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1 0.018 0.015 -9999 0 -0.24 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 0.029 0.013 -9999 0 -0.18 1 1
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.017 0.012 -9999 0 -0.25 1 1
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.017 0.017 -9999 0 -0.25 2 2
SUMO1/HDAC4 0.036 0.019 -9999 0 -0.31 1 1
SUMO1/HDAC1 0.036 0.018 -9999 0 -0.24 1 1
RANGAP1 0.014 0.037 -9999 0 -0.29 7 7
MDM2/SUMO1/SUMO1 0.04 0.031 -9999 0 -0.27 2 2
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 0.023 0.013 -9999 0 -0.2 1 1
Ran/GTP 0.031 0.013 -9999 0 -0.18 1 1
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.011 0.044 -9999 0 -0.25 14 14
UBE2I 0.018 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.037 0.013 -9999 0 -10000 0 0
NPC 0.01 0.008 -9999 0 -10000 0 0
PIAS2 0.015 0.035 -9999 0 -0.43 3 3
PIAS1 0.017 0.012 -9999 0 -0.25 1 1
EntrezGene:9972 0 0 -9999 0 -10000 0 0
Methods & Data
Input

  • Expression Data Normalization = Tumor samples were used to median center the expression data used in this analysis.

  • Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_MergeDataFilesPipeline/BRCA/1444279/2.GDAC_MergeDataFiles.Finished/BRCA.transcriptome__agilentg4502a_07_3__unc_edu__Level_3__unc_lowess_normalization_gene_level__data.data.txt

  • Copy Number File Used = Copy number data was not used in this analysis.

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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