rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 79 ANPEP(3), CD14(2), CD19(2), CD1B(1), CD1D(2), CD1E(1), CD22(5), CD33(3), CD34(2), CD36(2), CD38(2), CD3E(1), CD3G(1), CD44(4), CD5(2), CD55(2), CD7(2), CD8A(1), CD8B(1), CD9(2), CR1(5), CR2(6), CSF1R(3), CSF3R(2), DNTT(2), EPO(1), EPOR(1), FLT3(7), FLT3LG(1), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL1R1(2), IL2RA(3), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), ITGA1(1), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGAM(8), ITGB3(1), KIT(3), KITLG(2), MS4A1(2), TFRC(2), THPO(1), TPO(4) 31351365 137 76 135 51 54 23 28 20 12 0 0.00028 0.11 2 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 69 CALM1(1), CDS1(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(6), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), OCRL(1), PI4KA(1), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PRKCA(3), PRKCG(1), SYNJ1(1), SYNJ2(7) 46351323 183 92 181 48 68 29 33 25 27 1 0.00057 0.11 3 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 158 ADORA1(2), ADORA2B(1), ADORA3(1), ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCBP2(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CHML(2), CHRM2(4), CHRM3(3), CMKLR1(1), CNR1(2), CNR2(3), CX3CR1(2), CXCR3(2), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GPR17(1), GPR174(1), GPR27(3), GPR3(1), GPR37(3), GPR4(1), GPR50(3), GPR6(5), GPR83(4), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LHCGR(1), MC3R(6), MC4R(3), MC5R(2), MLNR(1), NMUR1(2), NMUR2(5), NPY5R(4), NTSR1(2), OPN1SW(2), OPRK1(1), OPRL1(2), OPRM1(4), OR1F1(2), OR1Q1(1), OR2H1(4), OR7A5(1), OR7C1(1), OXTR(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY6(2), PPYR1(2), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RHO(1), RRH(1), SSTR2(1), SSTR3(2), SSTR4(4), TRHR(2) 46757547 219 105 217 84 99 27 38 40 15 0 0.00070 0.11 4 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 238 ACVR1(3), ACVR2B(1), AMHR2(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CCL13(1), CCL15(1), CCL19(1), CCL2(2), CCL20(1), CCL22(1), CCL24(1), CCL26(1), CCL3(1), CCL5(1), CCL7(1), CCR1(2), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CD70(1), CLCF1(1), CNTF(1), CSF1R(3), CSF2RB(4), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL13(1), CXCL6(3), CXCR3(2), CXCR6(1), EDA(3), EGF(3), EPO(1), EPOR(1), FLT1(2), FLT3(7), FLT3LG(1), FLT4(3), GDF5(2), GH1(1), GH2(2), GHR(3), HGF(4), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL17RB(1), IL18R1(1), IL18RAP(4), IL1R1(2), IL1RAP(2), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), INHBA(3), INHBB(2), INHBE(1), KDR(10), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(1), MET(5), MPL(2), NGFR(1), OSM(1), OSMR(2), PDGFC(3), PDGFRB(5), PPBP(2), PRL(3), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF10A(2), TNFRSF11A(3), TNFRSF13B(2), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(3), TNFSF10(5), TNFSF11(4), TNFSF13B(2), TNFSF14(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFC(2), XCL1(2), XCL2(2), XCR1(1) 66065757 271 115 270 80 94 38 60 45 34 0 0.00075 0.11 5 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 GUSB(3), RPE(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), XYLB(4) 9832004 43 32 42 16 12 6 11 10 4 0 0.0010 0.12 6 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(4), NR0B2(3), NR1H3(1), NR1H4(3), RXRA(3) 2161711 14 14 14 3 3 2 4 3 2 0 0.0011 0.12 7 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(5), BDKRB1(1), BDKRB2(3), C1QB(1), C1QC(1), C1R(1), C1S(1), C2(2), C3(8), C3AR1(1), C5(1), C5AR1(1), C6(3), C7(6), C8A(3), C8B(5), C9(1), CD55(2), CFB(1), CFH(3), CFI(1), CPB2(1), CR1(5), CR2(6), F10(1), F13A1(5), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(2), MBL2(1), PLAU(2), PLAUR(1), PLG(2), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(5), THBD(3), VWF(10) 35749445 144 75 141 68 48 23 33 19 20 1 0.0021 0.18 8 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(1), GZMB(3), HLA-A(1), ITGAL(4), ITGB2(5), PRF1(3) 3417489 20 15 20 14 6 1 4 1 8 0 0.0047 0.35 9 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), LPA(6), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1), SERPINF2(1), VWF(10) 14027949 58 43 58 22 21 10 11 5 11 0 0.0052 0.35 10 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C1(3), AKR1C4(2), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1B1(4), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP2S1(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHDH(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3) 21984496 98 57 97 32 38 8 24 25 3 0 0.0063 0.37 11 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), COMT(2), DBH(6), DDC(1), FAH(1), GOT1(1), HPD(1), MAOB(1), PNMT(1), TAT(3), TPO(4), TYR(5) 12332970 66 42 64 14 35 9 9 13 0 0 0.0066 0.37 12 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CX3CR1(2), CXCR3(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GRPR(1), LHCGR(1), MC2R(1), MC3R(6), MC4R(3), MC5R(2), NPY5R(4), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR1(1), TACR3(4), TRHR(2), TSHR(1) 19940026 98 57 98 38 43 19 18 14 4 0 0.0075 0.39 13 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(1), CADM1(2), CADM3(1), CD22(5), CD226(2), CD274(1), CD276(3), CD28(1), CD34(2), CD58(1), CD6(2), CD8A(1), CD8B(1), CDH1(3), CDH15(3), CDH3(1), CDH4(3), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CNTN1(5), CNTN2(4), CNTNAP1(3), ESAM(1), F11R(1), GLG1(4), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), ICAM3(1), ICOSLG(1), ITGA4(7), ITGA6(2), ITGA8(7), ITGA9(1), ITGAL(4), ITGAM(8), ITGAV(1), ITGB2(5), ITGB7(2), ITGB8(3), JAM2(1), JAM3(1), L1CAM(7), MAG(5), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(5), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(3), NRXN3(3), OCLN(1), PDCD1(1), PECAM1(2), PTPRC(4), PTPRF(4), PTPRM(3), PVR(2), PVRL1(2), PVRL2(1), SDC1(1), SDC2(2), SDC4(1), SELE(1), SELP(2), SELPLG(2), SIGLEC1(1), VCAN(7) 57518880 209 106 208 97 81 29 35 32 31 1 0.0090 0.39 14 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(4), HDC(3), PNMT(1), TPH1(3) 2333567 17 13 17 6 10 4 2 1 0 0 0.0095 0.39 15 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), ETNK1(1), GNPAT(4), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH2(2), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB2(5), PLCG1(3), PLCG2(11), PPAP2C(1) 19614435 85 52 83 23 35 10 12 16 11 1 0.0096 0.39 16 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(3), CD5(2), CD7(2), IFNB1(1), IFNG(1), IL12B(1), IL4(1), ITGAX(7), TLR2(4), TLR4(1), TLR7(5), TLR9(2) 7416008 33 24 33 13 13 6 9 3 2 0 0.010 0.39 17 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 DNM1(5), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPHN(1), NSF(1), SRC(2), UBQLN1(2) 3977986 22 16 21 8 6 3 6 5 2 0 0.011 0.39 18 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPX1(2), PRKCE(1) 2387423 14 11 13 9 2 2 4 5 1 0 0.013 0.43 19 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 130 ACTB(1), CHAD(1), COL11A1(8), COL11A2(9), COL17A1(3), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DES(3), DSC1(5), DSC2(2), DSC3(2), DSG1(4), DSG2(1), DSG3(8), DSG4(10), FN1(3), GJA1(1), GJA10(1), GJA8(1), GJA9(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJC2(1), GJC3(1), INA(2), ITGA6(2), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT14(3), KRT15(1), KRT16(4), KRT17(3), KRT18(3), KRT19(5), KRT2(3), KRT20(1), KRT23(8), KRT24(1), KRT25(3), KRT28(3), KRT3(1), KRT31(3), KRT32(2), KRT33A(3), KRT33B(2), KRT34(3), KRT36(4), KRT37(2), KRT38(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(3), KRT72(1), KRT73(1), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(1), KRT82(1), KRT83(2), KRT84(2), KRT85(2), KRT9(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), LMNB1(1), LMNB2(3), NES(3), RELN(20), SPP1(1), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VIM(1), VWF(10) 92028094 408 154 404 168 154 79 71 48 55 1 0.014 0.45 20 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(7), AGT(3), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(5), REN(2) 3816834 27 16 27 9 11 5 5 3 3 0 0.015 0.47 21 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(2), CANX(4), CD8A(1), CD8B(1), CIITA(7), CTSS(2), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), HSP90AA1(1), HSP90AB1(2), HSPA5(2), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), LGMN(1), NFYB(1), NFYC(3), PDIA3(1), PSME1(1), PSME2(1), TAP1(4), TAP2(2) 18077249 71 47 70 26 16 11 17 12 15 0 0.019 0.51 22 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(1), AKT2(1), AKT3(1), BLNK(2), BTK(1), CARD11(6), CD19(2), CD22(5), CD72(2), CHUK(4), CR2(6), FOS(1), GSK3B(1), IFITM1(1), IKBKB(2), INPP5D(6), KRAS(1), LILRB3(1), LYN(1), MALT1(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(2), SYK(2), VAV1(6), VAV2(3), VAV3(2) 27775410 121 64 119 45 46 15 24 22 14 0 0.020 0.51 23 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(1), AKT2(1), AKT3(1), KDR(10), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NOS3(5), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), SH2D2A(2), SPHK1(1), SRC(2), VEGFA(2) 26123137 110 59 109 38 42 15 14 23 15 1 0.020 0.51 24 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(5), F2(1), FGA(3), FGB(1), FGG(4), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1) 5404654 22 20 22 8 9 5 4 2 2 0 0.020 0.51 25 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(1), EPO(1), FLT3(7), IL6(2), KITLG(2), TGFB1(1), TGFB2(1) 3311320 15 13 15 1 2 3 4 2 4 0 0.021 0.51 26 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1), SELP(2) 6700687 33 21 32 17 13 2 7 6 5 0 0.021 0.51 27 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 AKT1(1), ASAH1(1), CREB3(1), CREB5(1), CREBBP(8), DAG1(2), EGR1(2), EGR2(3), EGR3(4), ELK1(1), GNAQ(1), MAP1B(9), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NTRK1(4), OPN1LW(3), PIK3CD(2), PTPN11(6), RPS6KA3(5), SRC(2), TERF2IP(3) 16881445 78 46 78 19 21 13 21 17 6 0 0.023 0.52 28 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 293806 3 3 3 1 2 1 0 0 0 0 0.026 0.56 29 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1) 4433802 24 15 23 13 8 2 7 2 5 0 0.026 0.56 30 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 2753369 12 12 12 5 7 2 1 1 1 0 0.027 0.56 31 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), CHAT(3), COMT(2), DBH(6), DDC(1), GAD1(4), GAD2(3), HDC(3), PAH(1), PNMT(1), TPH1(3) 5608230 28 21 28 9 13 5 3 7 0 0 0.030 0.60 32 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 106 ACTN1(1), ACTN3(1), ACTN4(4), ARHGAP5(2), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(2), ESAM(1), EZR(3), F11R(1), GNAI2(1), GRLF1(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), JAM2(1), JAM3(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(1), MMP9(2), MSN(1), MYL2(2), MYLPF(1), NCF1(2), NCF4(1), NOX1(2), NOX3(5), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), RAPGEF3(1), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(2), ROCK1(3), ROCK2(4), SIPA1(3), TXK(1), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2) 46924543 179 86 177 79 67 19 42 27 24 0 0.034 0.60 33 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(1), CD244(1), FCER1G(1), FCGR3A(1), GZMB(3), HCST(1), HLA-A(1), HLA-B(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), ITGAL(4), ITGB2(5), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), KLRK1(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MICB(1), NCR1(2), NCR2(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), PAK1(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRF1(3), PRKCA(3), PRKCG(1), PTK2B(1), PTPN11(6), PTPN6(4), SH2D1B(1), SH3BP2(2), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SYK(2), TNFRSF10A(2), TNFSF10(5), ULBP1(1), VAV1(6), VAV2(3), VAV3(2), ZAP70(5) 42313032 161 79 161 77 52 18 37 30 24 0 0.034 0.60 34 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F5(9), F7(1), FGA(3), FGB(1), FGG(4), PROC(2), SERPINC1(2) 6457793 24 19 24 9 7 5 6 1 5 0 0.035 0.60 35 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), GALNS(1), GBA(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NAGLU(1), NEU1(1), NEU2(4), NEU4(4), SPAM1(6) 13554921 52 37 50 16 19 3 10 9 11 0 0.035 0.60 36 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 39 ALAS1(2), ALAS2(1), BLVRA(1), BLVRB(1), COX10(1), COX15(1), CP(4), CPOX(1), EARS2(2), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UROD(1), UROS(1) 15734582 66 40 65 21 16 6 15 20 9 0 0.035 0.60 37 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 49 ADORA3(1), CCKBR(2), CCR3(2), CELSR1(10), CELSR2(9), CELSR3(8), CHRM2(4), CHRM3(3), CXCR3(2), EDNRA(1), EMR2(4), EMR3(2), FSHR(1), GHRHR(3), GPR116(9), GPR132(3), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR56(2), GPR61(2), GPR84(1), GPR88(1), GRM1(1), GRPR(1), HRH4(1), LGR6(3), LPHN2(4), LPHN3(2), LTB4R2(2), NTSR1(2), OR2M4(2), OR8G2(1), P2RY13(3), PTGFR(2), SMO(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(1) 24791623 110 57 110 45 40 15 21 20 14 0 0.036 0.61 38 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(2), LRP8(2), RELN(20), VLDLR(2) 5680593 27 18 27 18 10 8 1 3 5 0 0.038 0.61 39 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(3), CTH(1), GOT1(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MPST(1), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(1), SULT4A1(1) 5047540 24 16 24 4 3 6 7 4 4 0 0.039 0.61 40 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 ACTA1(1), AKT1(1), BDKRB2(3), CALM1(1), CAV1(1), FLT1(2), FLT4(3), KDR(10), NOS3(5), PDE2A(3), PDE3A(1), PDE3B(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG2(5), SLC7A1(2), SYT1(1), TNNI1(2) 12178594 48 34 48 16 17 7 4 12 8 0 0.042 0.61 41 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(1), TAT(3), TYR(5) 1908974 10 9 10 1 1 3 2 4 0 0 0.042 0.61 42 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), MINPP1(1), MIOX(1), OCRL(1), PI4KA(1), PI4KB(3), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), SYNJ1(1), SYNJ2(7) 27995081 106 58 105 32 40 17 19 13 16 1 0.042 0.61 43 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), F10(1), F2(1), F5(9), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), PROC(2), SERPINC1(2), SERPING1(5) 17935830 70 45 68 18 20 17 13 10 10 0 0.042 0.61 44 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(3), SP1(6), SP3(1) 1979947 11 9 11 3 2 1 2 3 3 0 0.044 0.62 45 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ABP1(9), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), SDS(4), UPB1(1) 11727333 58 33 58 12 19 13 10 11 5 0 0.046 0.64 46 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1) 4933029 22 16 21 14 7 2 6 4 2 1 0.048 0.64 47 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), CREBBP(8), DFFA(1), DFFB(3), GZMA(1), GZMB(3), PRF1(3) 4170990 21 15 21 5 4 3 6 4 4 0 0.052 0.69 48 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(8), DVL2(2), EDNRB(1), EP300(5), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GSK3B(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MITF(2), NRAS(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), TCF7(3), TCF7L2(3), TYR(5), TYRP1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4) 42357653 175 82 171 50 59 21 39 31 23 2 0.056 0.71 49 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(4), ABCA10(2), ABCA12(2), ABCA13(5), ABCA2(3), ABCA4(6), ABCA5(4), ABCA6(2), ABCA7(3), ABCA8(1), ABCA9(4), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(8), ABCB5(7), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(2), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(5), ABCC4(4), ABCC5(7), ABCC6(5), ABCC8(6), ABCD1(4), ABCD2(4), ABCD3(2), ABCG1(2), ABCG2(2), ABCG4(6), ABCG5(3), ABCG8(3), CFTR(7), TAP1(4), TAP2(2) 44048101 148 71 147 57 53 18 32 19 23 3 0.064 0.81 50 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(2), ENPP3(1), NADSYN1(4), NMNAT2(1), NNMT(1), QPRT(3) 5902823 19 17 16 2 8 2 2 6 1 0 0.066 0.81 51 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD34(2), CD3E(1), CD3G(1), CD58(1), CD8A(1), IL6(2), KITLG(2) 2148473 10 9 10 2 4 0 3 1 2 0 0.068 0.81 52 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), RPS6KB1(1), STAT6(3) 5883058 23 18 22 6 8 3 3 7 2 0 0.069 0.81 53 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ABP1(9), AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), DAO(3), GAMT(1), GATM(2), GOT1(1), MAOB(1), NOS1(9), NOS3(5), OAT(1), ODC1(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1) 17269425 74 44 73 19 28 17 11 17 1 0 0.070 0.81 54 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(4), JAK3(4), MAPK1(3), MAPK3(2), STAT3(2), TYK2(3) 4692033 21 16 19 3 9 3 3 5 1 0 0.077 0.88 55 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1) 2311758 13 9 13 2 8 0 3 2 0 0 0.084 0.89 56 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 CALCR(6), CALCRL(2), CRHR1(2), ELTD1(5), EMR1(4), EMR2(4), GHRHR(3), GIPR(1), GLP1R(1), GLP2R(1), GPR64(2), LPHN2(4), LPHN3(2), SCTR(2), VIPR2(2) 9586511 41 26 41 16 14 5 8 8 6 0 0.084 0.89 57 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(1), AKT2(1), AKT3(1), ANKRD6(3), APC(7), AXIN1(2), AXIN2(1), DACT1(5), DKK1(1), DKK2(3), FSTL1(2), GSK3B(1), LRP1(15), MVP(2), NKD2(2), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2) 15524662 58 37 52 11 18 3 15 14 8 0 0.085 0.89 58 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 10 CREBBP(8), DAXX(4), PAX3(3), PML(2), SIRT1(2), SP100(3), TNFRSF1A(2), TNFRSF1B(2) 6197133 26 18 26 8 6 5 7 4 4 0 0.087 0.89 59 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), IL6(2), LDLR(4) 2160204 8 8 8 3 1 1 3 2 1 0 0.088 0.89 60 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(3), CD36(2), CD44(4), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), DAG1(2), FN1(3), FNDC1(1), FNDC3A(2), GP9(1), HMMR(1), HSPG2(16), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), RELN(20), SDC1(1), SDC2(2), SDC4(1), SPP1(1), SV2B(1), SV2C(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VWF(10) 83707935 323 133 320 121 118 67 51 41 45 1 0.089 0.89 61 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 4 CD28(1), CD3E(1), CD3G(1) 655647 3 3 3 1 1 0 1 0 1 0 0.092 0.89 62 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), LPO(1), MPO(3), PRDX2(2), TPO(4), TYR(5) 3807130 21 14 21 8 11 1 2 4 3 0 0.092 0.89 63 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MAX(2), SP1(6), SP3(1), WT1(3) 2504554 13 10 13 1 4 2 2 1 4 0 0.092 0.89 64 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), KERA(2), LUM(3) 1446169 7 7 6 4 2 2 1 0 2 0 0.092 0.89 65 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(4), ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(4), CACNA1B(7), GNAS(3), GNAT3(3), GNB1(1), GNB3(1), GRM4(5), ITPR3(11), KCNB1(3), PDE1A(1), PLCB2(5), PRKACG(1), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R14(2), TAS2R16(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R41(3), TAS2R42(1), TAS2R60(1), TAS2R8(1), TRPM5(1) 21727627 89 52 88 45 39 11 16 14 9 0 0.094 0.89 66 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(5), CACNA1D(9), CACNA1F(10), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CGA(1), ELK1(1), GNA11(2), GNAQ(1), GNAS(3), GNRH1(1), GNRH2(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK9(2), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLD2(1), PRKACG(1), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(1), SOS1(1), SOS2(4), SRC(2) 49572904 202 89 200 63 81 28 34 36 21 2 0.10 0.94 67 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(2), ABCB4(8), ABCC1(3), ABCC3(5), GSTP1(1) 5751848 23 18 23 12 9 4 2 4 4 0 0.10 0.94 68 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR109B(3), GPR161(2), GPR18(1), GPR34(1), GPR45(2), GPR65(1), GPR68(2), GPR81(2) 3922283 16 12 16 5 6 2 2 4 2 0 0.10 0.94 69 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ITGA4(7), ITGAL(4), ITGB2(5), PECAM1(2), SELE(1) 5304269 23 14 23 13 7 1 4 6 5 0 0.11 0.94 70 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(4), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(5), NFATC1(3), NFATC2(1), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SYT1(1), VIP(1), VIPR2(2) 10901738 36 28 35 16 7 4 4 12 9 0 0.11 0.94 71 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(9), AOC2(2), AOC3(2), CES1(2) 2419051 15 10 15 1 8 3 1 3 0 0 0.11 0.94 72 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 143 AKT1(1), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND2(1), CLCF1(1), CNTF(1), CREBBP(8), CSF2RB(4), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(3), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), IRF9(2), JAK1(3), JAK2(4), JAK3(4), LEPR(1), LIFR(1), MPL(2), OSM(1), OSMR(2), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PRL(3), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(1), SOCS4(2), SOS1(1), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(2), STAM2(2), STAT1(1), STAT2(5), STAT3(2), STAT4(1), STAT5A(2), STAT5B(2), STAT6(3), TPO(4), TYK2(3) 55040248 199 88 196 72 71 28 47 34 18 1 0.12 0.94 73 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(1), AKT2(1), AKT3(1), BTK(1), FCER1A(3), FCER1G(1), GAB2(3), IL4(1), INPP5D(6), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PRKCA(3), PRKCD(5), PRKCE(1), SOS1(1), SOS2(4), SYK(2), VAV1(6), VAV2(3), VAV3(2) 26888762 113 56 113 46 49 16 17 17 13 1 0.12 0.94 74 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(1), AKT2(1), AKT3(1), CCL3(1), CCL5(1), CD14(2), CHUK(4), FOS(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IKBKB(2), IL12B(1), IL6(2), IRAK1(2), IRAK4(2), LBP(2), LY96(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), RIPK1(1), SPP1(1), STAT1(1), TBK1(2), TLR1(2), TLR2(4), TLR4(1), TLR5(4), TLR6(6), TLR7(5), TLR8(3), TLR9(2), TRAF3(3) 33670243 110 59 109 52 29 21 18 27 15 0 0.12 0.94 75 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 5 CCL2(2), MST1R(6) 2032362 8 8 8 5 4 0 0 3 1 0 0.12 0.94 76 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(2), ARSD(1), ARSE(1), CARM1(1), CYP11B2(4), CYP19A1(3), HSD11B1(2), HSD17B3(1), HSD17B7(1), HSD17B8(1), HSD3B2(2), LCMT1(1), PRMT7(2), PRMT8(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3) 18808187 61 42 60 32 19 8 17 13 4 0 0.12 0.94 77 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(2), ACADS(4), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), SDS(4) 10403076 48 27 48 14 13 12 7 9 7 0 0.12 0.94 78 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL2RA(3), IL4(1), IL4R(6) 5130651 28 15 28 4 12 5 4 5 2 0 0.13 0.94 79 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(9), FASN(7), MCAT(1), OXSM(3) 5930850 28 17 28 7 11 1 8 5 3 0 0.13 0.94 80 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), JAK1(3), STAT1(1), STAT2(5), TYK2(3) 4326909 14 12 14 3 4 2 5 1 2 0 0.13 0.94 81 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), NAGLU(1), SPAM1(6) 8100775 32 22 31 10 12 2 6 6 6 0 0.13 0.94 82 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(1), CD3G(1), CD8A(1), ITGAL(4), ITGB2(5), PTPRC(4) 4298928 17 12 17 12 5 2 3 0 7 0 0.13 0.94 83 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 3532572 12 11 12 7 6 3 2 0 1 0 0.13 0.94 84 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 3532572 12 11 12 7 6 3 2 0 1 0 0.13 0.94 85 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 227 ADORA1(2), ADORA2B(1), ADORA3(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), C5AR1(1), CALCR(6), CALCRL(2), CCKAR(3), CCKBR(2), CGA(1), CHRM2(4), CHRM3(3), CNR1(2), CNR2(3), CRHR1(2), CTSG(4), CYSLTR1(1), CYSLTR2(1), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR1(1), GABBR2(6), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRB1(3), GABRB3(2), GABRD(2), GABRG1(2), GABRG2(6), GABRP(4), GABRQ(2), GABRR2(1), GALR1(3), GALR2(1), GH1(1), GH2(2), GHR(3), GHRHR(3), GHSR(4), GIPR(1), GLP1R(1), GLP2R(1), GLRA2(1), GLRA3(3), GLRB(1), GPR156(3), GPR50(3), GPR83(4), GRIA1(4), GRIA3(5), GRIA4(2), GRID1(3), GRID2(1), GRIK1(1), GRIK2(2), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRIN3B(1), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM6(6), GRM7(3), GRM8(8), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HRH4(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R2(2), MC2R(1), MC3R(6), MC4R(3), MC5R(2), MCHR1(2), MCHR2(3), MLNR(1), NMUR1(2), NMUR2(5), NPBWR1(2), NPFFR1(2), NPFFR2(2), NPY5R(4), NR3C1(1), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY4(2), P2RY6(2), PARD3(2), PPYR1(2), PRL(3), PRSS1(1), PTAFR(2), PTGDR(1), PTGER2(2), PTGER3(2), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(3), RXFP2(1), SCTR(2), SSTR2(1), SSTR3(2), SSTR4(4), SSTR5(2), TAAR2(1), TAAR5(1), TACR1(1), TACR3(4), THRA(1), TRHR(2), TSHB(1), TSHR(1), TSPO(1), UTS2R(1), VIPR2(2) 84158765 383 144 382 165 173 49 62 67 32 0 0.13 0.94 86 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NFKB1(1), SP1(6) 5623970 22 16 22 5 4 5 2 5 6 0 0.14 0.94 87 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(1) 1952432 8 8 6 1 6 0 1 1 0 0 0.14 0.94 88 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(5), AMY2B(1), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHX58(2), ENPP3(1), EP400(15), ERCC2(1), ERCC3(2), G6PC(2), GAA(3), GANC(1), GBA(1), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), IFIH1(2), MGAM(7), MOV10L1(2), PGM3(2), PYGB(4), PYGL(1), PYGM(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SI(3), SKIV2L2(1), SMARCA2(5), SMARCA5(2), TREH(2), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UXS1(1) 48283018 159 79 156 56 56 23 34 28 18 0 0.14 0.94 89 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(2), CDKN2A(3), FLOT1(2), GAB1(1), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), NR0B2(3), PLCG2(11), PREX1(9), PTPRC(4), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SYK(2), TEC(5), VAV1(6) 20753223 91 48 91 29 32 17 18 12 12 0 0.14 0.94 90 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGAT2(2), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), GK(1), GK2(2), GLA(1), GLB1(1), GPAM(2), LCT(8), LIPC(1), LIPG(5), MGLL(2), PNLIP(2), PNLIPRP1(2), PNPLA3(1), PPAP2C(1) 23080983 89 50 88 25 37 11 17 16 8 0 0.14 0.94 91 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), GK(1), GLA(1), GLB1(1), LCT(8), LIPC(1), LIPG(5), PNLIP(2), PNLIPRP1(2), PPAP2C(1) 18858900 84 44 83 21 34 14 17 12 7 0 0.14 0.94 92 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(4), GPAM(2), GPD1(2), GPD2(1), LCAT(1), MYST3(4), MYST4(4), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1), PTDSS2(1), SH3GLB1(2) 25960462 89 52 87 26 30 11 15 18 14 1 0.14 0.94 93 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 ALOX15(2), ALOX5(1), CBR1(1), CBR3(2), CYP4F2(5), CYP4F3(5), EPX(6), GGT1(2), LPO(1), LTA4H(1), MPO(3), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PRDX2(2), PTGIS(1), PTGS1(2), TBXAS1(3), TPO(4) 10927491 51 31 51 18 28 5 6 5 6 1 0.15 0.94 94 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 APH1A(3), CREBBP(8), CTBP1(3), CTBP2(4), DLL3(1), DTX1(1), DTX3L(1), DVL2(2), EP300(5), HDAC1(1), HDAC2(3), HES1(1), JAG1(3), JAG2(5), LFNG(1), MAML1(3), MAML2(2), MAML3(1), MFNG(2), NCOR2(5), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMB(1), NUMBL(2), PSEN2(1), RBPJ(1), RBPJL(4), SNW1(1) 25862211 87 52 84 29 27 12 20 15 12 1 0.15 0.94 95 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(1) 468602 2 2 2 1 0 0 1 0 1 0 0.15 0.94 96 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), NOS1(9), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SYT1(1) 9871541 44 29 42 19 20 3 8 11 2 0 0.15 0.94 97 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(1), LPO(1), MPO(3), TPO(4) 3329226 15 12 15 7 11 0 0 1 3 0 0.15 0.94 98 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP5(2), ACP6(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CMBL(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHRS7(1), PON1(4), PON3(2) 6896273 31 19 31 7 12 3 7 8 1 0 0.15 0.94 99 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1), NTAN1(1), SIRT1(2), SIRT2(2), VNN2(1) 4653069 13 11 13 1 2 2 1 2 6 0 0.15 0.94 100 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 8 EGF(3), MAP2K1(1), MAP3K1(5), MAPK14(1), NCOR2(5), RXRA(3), THRA(1) 5254910 19 14 19 7 4 3 2 5 5 0 0.15 0.94 101 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 1940571 9 7 9 2 0 4 1 1 3 0 0.16 0.96 102 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PIK3CD(2), SYT1(1), TRAF2(2), TRAF3(3), TRAF5(1) 11061156 43 28 43 13 13 4 9 11 6 0 0.16 0.96 103 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(3), EPHB1(10), ITGA1(1), L1CAM(7), LYN(1), RAP1B(2), SELP(2) 6284921 27 17 26 8 11 5 6 3 2 0 0.16 0.97 104 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(1), C6(3), C7(6), IL6(2), ITGA4(7), ITGAL(4), ITGB2(5), SELP(2), SELPLG(2) 9840865 40 25 39 26 13 3 7 8 8 1 0.16 0.97 105 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 21 IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MIOX(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PIK3CG(12), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11) 15943347 64 37 63 19 23 11 15 5 9 1 0.17 0.97 106 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ABP1(9), ACADM(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), UPB1(1) 10880045 46 28 46 9 17 7 8 11 3 0 0.17 0.97 107 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD28(1), CD3E(1), CD3G(1), ITGAL(4), ITGB2(5), PTPRC(4) 4160681 16 11 16 12 4 2 3 0 7 0 0.17 0.97 108 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), CHRM2(4), CHRM3(3), DRD1(2), DRD2(1), DRD3(1), DRD5(4), HRH1(1), HRH2(5), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1) 9718968 48 29 48 18 23 5 8 8 4 0 0.17 0.97 109 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(1), GSS(1), NFKB1(1), NOX1(2), XDH(8) 4061497 15 11 14 5 2 3 7 1 2 0 0.17 0.97 110 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), MAPK1(3), MAPK3(2), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(4), PLCG1(3) 5981265 19 18 19 10 5 5 4 5 0 0 0.17 0.97 111 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE1(1), CCNE2(1), CDKN1B(3), CDKN2A(3), E2F2(3) 3378480 12 11 12 8 3 3 1 1 4 0 0.18 0.99 112 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(3) 1070053 4 4 4 0 1 2 1 0 0 0 0.18 0.99 113 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 12 CASR(5), GABBR1(1), GPRC5A(1), GPRC5C(1), GPRC5D(2), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM7(3), GRM8(8) 7588700 29 21 29 26 14 1 6 4 4 0 0.18 1.00 114 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 14 CD28(1), CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), PTPN11(6) 3153520 13 10 13 5 2 3 3 4 1 0 0.19 1.00 115 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(4), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2) 12777875 58 33 54 16 28 6 10 10 4 0 0.19 1.00 116 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), PIAS3(4), PTPRU(3), SRC(2), STAT3(2) 6157097 26 19 23 4 12 4 3 5 2 0 0.19 1.00 117 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(2), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CLCA1(3), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(2), CNGB1(5), GNAL(1), GUCA1B(1), GUCA1C(3), PDE1C(4), PRKACG(1), PRKG2(5), PRKX(2) 12240769 45 30 44 22 13 7 11 11 3 0 0.19 1.00 118 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), DHFR(1), FPGS(2) 2450112 11 9 11 4 4 0 4 2 1 0 0.20 1.00 119 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(9), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DDC(1), HAL(2), HARS(3), HDC(3), HNMT(1), MAOB(1), PRPS2(2) 9896289 48 27 48 9 24 9 5 8 2 0 0.20 1.00 120 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(1), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(4), GOT1(1), NOS1(9), NOS3(5), OAT(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(1), RARS2(1) 13953345 52 33 51 16 20 8 11 12 1 0 0.20 1.00 121 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(7), ACE2(2), AGT(3), AGTR1(2), AGTR2(1), ANPEP(3), CTSA(2), CTSG(4), ENPEP(9), LNPEP(2), NLN(1), REN(2), THOP1(1) 8431879 39 22 39 13 17 5 8 3 6 0 0.20 1.00 122 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 GUSB(3), RPE(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5) 6320515 18 16 18 11 4 5 3 3 3 0 0.20 1.00 123 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), COMT(2), DBH(6), DDC(1), ESCO1(2), FAH(1), GOT1(1), HPD(1), LCMT1(1), MAOB(1), MYST3(4), MYST4(4), PNMT(1), PNPLA3(1), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(3), TPO(4), TYR(5), TYRP1(2) 23154003 86 51 84 23 40 11 12 18 5 0 0.20 1.00 124 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3) 4182675 17 12 16 5 10 2 3 1 1 0 0.20 1.00 125 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3) 4182675 17 12 16 5 10 2 3 1 1 0 0.20 1.00 126 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(7), CD44(4), FCGR3A(1), IL6R(2), TGFB1(1), TGFB2(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(3), TNFSF8(1) 5271297 24 14 24 7 6 4 6 3 5 0 0.21 1.00 127 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), PRDX2(2), TAT(3), TPO(4) 8803849 43 26 43 10 23 5 4 8 3 0 0.21 1.00 128 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX1(2), ACOX3(1), FADS2(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3) 3962896 19 12 19 6 7 1 2 4 4 1 0.21 1.00 129 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(2), AP2M1(4), BIN1(1), CALM1(1), DNM1(5), EPN1(1), EPS15(1), PICALM(2), PPP3CB(1), SYNJ1(1), SYNJ2(7), SYT1(1) 8612476 33 21 32 7 9 6 8 3 7 0 0.21 1.00 130 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4) 8067047 29 21 28 9 14 1 5 4 5 0 0.22 1.00 131 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), ELAVL1(1), FLT1(2), FLT4(3), HIF1A(1), KDR(10), NOS3(5), PLCG1(3), PRKCA(3), PTK2(2), PXN(1), VHL(1) 11874292 41 28 41 12 13 5 6 11 6 0 0.22 1.00 132 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 19 ACY1(1), ALDH18A1(1), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), GAMT(1), GATM(2), OAT(1), ODC1(1), OTC(2) 6636656 21 16 21 5 4 5 4 7 1 0 0.22 1.00 133 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(2), HLA-A(1), KLRC1(1), KLRC3(3), MAP2K1(1), MAPK3(2), PAK1(2), PTK2B(1), PTPN6(4), SYK(2), VAV1(6) 5990598 25 15 25 12 7 1 12 2 3 0 0.22 1.00 134 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(3), SCAP(5), SREBF1(2), SREBF2(3) 4554029 18 12 18 6 7 2 4 0 5 0 0.23 1.00 135 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 13 CD3E(1), CD3G(1), CXCR3(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(4), STAT4(1), TYK2(3) 5256848 22 14 21 8 11 1 5 1 4 0 0.23 1.00 136 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), IKBKB(2), IL1R1(2), IRAK1(2), MAP3K1(5), MAP3K14(2), MAP3K7(2), NFKB1(1), NFKBIA(2), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2) 9716920 29 22 28 14 4 5 6 10 4 0 0.23 1.00 137 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME3(3), PGK2(3), PKLR(4), RPE(1), TKT(2), TKTL1(2), TKTL2(2) 7845277 34 21 34 8 11 5 7 8 3 0 0.23 1.00 138 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(5), TYK2(3) 5024612 16 14 16 4 7 1 5 1 2 0 0.24 1.00 139 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 ERBB2(7), ERBB4(1), ETV7(1), FMN2(2), KRAS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(3), PIWIL3(4), PIWIL4(1), SOS1(1), SOS2(4), SPIRE1(3), SPIRE2(4) 18770439 60 39 55 20 15 5 10 16 14 0 0.24 1.00 140 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), CHUK(4), ELK1(1), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(1), RALA(1), RALBP1(3), RALGDS(3), RHOA(1) 6100778 19 15 18 5 4 1 3 6 5 0 0.24 1.00 141 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), NR3C1(1), RETN(1), RXRA(3) 2319283 7 7 7 4 1 2 0 1 3 0 0.24 1.00 142 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), PTPRC(4), ZAP70(5) 3302814 14 9 14 5 4 4 2 1 3 0 0.25 1.00 143 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 25 CCL3(1), CCR1(2), CCR3(2), CCR4(1), CCR7(2), CD28(1), CXCR3(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL4(1), IL4R(6), TGFB1(1), TGFB2(1) 7153969 34 18 34 6 12 3 8 5 6 0 0.25 1.00 144 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), C9orf95(1), CD38(2), ENPP3(1), NADK(3), NADSYN1(4), NMNAT2(1), NNMT(1), NT5C1B(3), NT5C2(2), QPRT(3) 8700021 28 21 25 8 10 2 5 9 2 0 0.26 1.00 145 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 BLVRA(1), BLVRB(1), CP(4), CPOX(1), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UROD(1), UROS(1) 10330169 38 24 38 16 10 4 6 12 6 0 0.26 1.00 146 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3) 9003646 30 21 29 12 6 3 6 11 4 0 0.26 1.00 147 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(8), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CREBBP(8), EP300(5), GNAQ(1), GRIA1(4), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NRAS(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RAP1B(2), RAPGEF3(1), RPS6KA2(2), RPS6KA3(5) 38930540 149 68 146 54 52 23 34 25 13 2 0.27 1.00 148 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1) 6877628 27 17 26 20 9 3 7 5 2 1 0.27 1.00 149 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(1), PDE1A(1), PLCB1(3), PLCB2(5), PRL(3), TRH(1), VIP(1) 4434609 18 11 18 5 10 3 2 1 1 1 0.27 1.00 150 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), HLA-DRA(1), HLA-DRB1(2) 599954 4 3 4 0 1 2 0 1 0 0 0.28 1.00 151 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), CHST1(2), CHST2(3), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL3(1) 4837895 20 14 20 5 6 6 2 5 1 0 0.28 1.00 152 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(1), IL12B(1), IL2(1) 1206627 7 4 7 0 1 2 0 2 2 0 0.28 1.00 153 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(8), GNA12(2), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1) 4103160 15 11 15 5 4 1 3 5 2 0 0.28 1.00 154 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4) 19416741 88 44 87 15 42 14 13 13 6 0 0.28 1.00 155 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4) 19416741 88 44 87 15 42 14 13 13 6 0 0.28 1.00 156 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CAMKK1(3), CAMKK2(1), SYT1(1) 4626443 15 13 15 6 3 1 2 6 3 0 0.29 1.00 157 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(3), TNFSF11(4) 4476253 12 11 12 7 4 3 2 0 3 0 0.29 1.00 158 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SPTLC1(2), SPTLC2(1), UGCG(1) 9552915 35 23 34 15 12 5 4 4 9 1 0.29 1.00 159 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 207423 1 1 1 0 1 0 0 0 0 0 0.29 1.00 160 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(1), CDKN1B(3), CDKN2A(3), E2F2(3), MDM2(1) 2835188 11 10 11 7 2 5 0 0 4 0 0.29 1.00 161 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 4899111 23 13 23 5 5 8 4 3 3 0 0.29 1.00 162 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 5388913 21 14 21 5 11 1 5 4 0 0 0.29 1.00 163 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(1) 620625 2 2 2 0 0 0 1 1 0 0 0.29 1.00 164 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(9), AGXT2(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PISD(3), PLCB2(5), PLCG1(3), PLCG2(11), PSPH(2), SHMT2(1), TARS(2) 16243288 68 37 68 18 29 14 11 8 6 0 0.30 1.00 165 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(1), AKT2(1), AKT3(1), CAB39(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(1), MAPK1(3), MAPK3(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PRKAA2(1), RICTOR(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TSC1(4), TSC2(2), ULK1(1), ULK2(6), ULK3(1), VEGFA(2), VEGFC(2) 18505523 68 39 68 22 22 12 10 11 13 0 0.30 1.00 166 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), TNFAIP3(1), TRAF3(3) 7318170 24 16 23 9 3 3 4 10 4 0 0.30 1.00 167 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(8), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SDS(4), SUCLA2(1), SUCLG1(2) 13418593 50 29 50 11 12 13 10 6 9 0 0.30 1.00 168 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(3), ACVRL1(2), AKT1(1), BMPR1A(2), BMPR2(2), BUB1(4), CDKL1(3), CDS1(1), CLK2(2), CLK4(2), CSNK2A1(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11), PLK3(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TGFBR1(1) 42886776 152 69 150 44 49 30 25 25 22 1 0.30 1.00 169 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C8B(5), C9(1), MASP1(2) 8218368 34 20 33 21 10 5 9 7 2 1 0.31 1.00 170 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 88 AKT1(1), AKT2(1), AKT3(1), CARD11(6), CBL(1), CBLB(1), CBLC(1), CD28(1), CD3E(1), CD3G(1), CD8A(1), CD8B(1), CHUK(4), FOS(1), GRAP2(1), IFNG(1), IKBKB(2), IL2(1), IL4(1), KRAS(1), MALT1(3), MAP3K14(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDCD1(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCQ(1), PTPN6(4), PTPRC(4), RASGRP1(1), RHOA(1), SOS1(1), SOS2(4), TEC(5), VAV1(6), VAV2(3), VAV3(2), ZAP70(5) 37678058 126 63 125 55 42 17 26 25 16 0 0.31 1.00 171 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(1), FOS(1), IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2), STAT3(2) 9560632 34 23 32 6 11 5 6 8 4 0 0.31 1.00 172 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(2) 10143840 39 26 37 13 15 10 4 4 6 0 0.31 1.00 173 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(1), NAT2(1), XDH(8) 3252534 12 10 12 4 3 2 4 1 2 0 0.31 1.00 174 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.32 1.00 175 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.32 1.00 176 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.32 1.00 177 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2B(1), ADORA3(1), P2RY1(1), P2RY2(2), P2RY6(2) 2363953 9 8 9 1 3 0 2 2 2 0 0.32 1.00 178 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4) 6545653 23 15 22 7 11 1 3 4 4 0 0.32 1.00 179 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME2(2), ME3(3), PKLR(4), RPE(1), TKT(2) 6979042 29 18 29 6 10 3 6 8 2 0 0.32 1.00 180 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(5), ESR1(3), MAPK1(3), MAPK3(2), PELP1(2), SRC(2) 5861877 25 14 25 4 6 5 8 4 1 1 0.32 1.00 181 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(8), CD3E(1), CD3G(1), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8585976 38 23 38 11 14 8 7 4 5 0 0.32 1.00 182 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(8), CD3E(1), CD3G(1), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8585976 38 23 38 11 14 8 7 4 5 0 0.32 1.00 183 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(4), ELK1(1), FOS(1), IKBKB(2), IRAK1(2), LY96(1), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), PPARA(1), TLR10(1), TLR2(4), TLR4(1), TLR6(6), TLR7(5), TLR9(2) 14541644 47 32 46 25 9 13 8 12 5 0 0.32 1.00 184 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), JAK2(4), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(3), SOAT1(2) 5522242 22 15 19 4 12 1 4 4 1 0 0.32 1.00 185 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNB1(1), IKBKB(2), IL1R1(2), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(2), IRAK2(3), IRAK3(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), TGFB1(1), TGFB2(1) 11783783 37 26 36 16 5 5 5 13 9 0 0.33 1.00 186 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(12), CALM1(1), CAPN2(1), CAPNS1(1), EP300(5), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(3), NFATC2(1), PPP3CB(1), PRKCA(3), SYT1(1) 9559706 34 22 34 10 9 3 8 9 4 1 0.33 1.00 187 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 IFNG(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(4), NFKB1(1), NFKBIA(2), TNFRSF1A(2), TNFRSF1B(2), USH1C(1), WT1(3) 6173227 20 14 19 8 7 1 4 5 3 0 0.33 1.00 188 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 BTK(1), CAD(6), CASP8AP2(3), CD7(2), DAXX(4), DFFA(1), DIABLO(1), EPHB2(6), FAF1(3), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MET(5), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), NR0B2(3), PTPN13(4), RALBP1(3), RIPK1(1), ROCK1(3), TNFRSF6B(2), TPX2(1), TRAF2(2), TUFM(1) 26766043 92 46 92 30 25 17 20 18 12 0 0.34 1.00 189 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2), TOB1(2), TOB2(1) 4320259 22 10 22 3 5 3 4 3 7 0 0.34 1.00 190 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(12), CALM1(1), CAMK1(2), HDAC5(4), IGF1R(2), INSR(5), MAPK14(1), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2), NFATC1(3), NFATC2(1), PPP3CB(1), SYT1(1) 12060348 42 29 42 14 11 8 9 9 5 0 0.35 1.00 191 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), PON1(4) 11601263 49 29 49 17 21 2 14 11 1 0 0.36 1.00 192 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2) 2695597 11 7 11 1 2 3 2 2 2 0 0.36 1.00 193 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(5), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2) 3035540 12 8 12 4 1 4 4 1 2 0 0.36 1.00 194 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SP1(6), SP3(1), SYT1(1) 8245499 26 19 26 11 4 4 4 8 6 0 0.36 1.00 195 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4) 14781438 56 32 56 14 17 10 12 10 7 0 0.37 1.00 196 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(3), PLCG1(3), PRKCA(3), VAV1(6) 3662901 16 9 16 7 5 4 4 2 0 1 0.37 1.00 197 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), DFFB(3), GZMB(3), TOP2A(1), TOP2B(1) 3551959 9 8 9 2 2 0 2 3 2 0 0.37 1.00 198 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(2), ARSB(2), ARSD(1), ARSE(1), CYP11B2(4), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B2(2), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5) 10343168 33 23 33 22 10 6 7 6 4 0 0.37 1.00 199 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(4), APOE(1), CETP(2), HMGCR(1), LCAT(1), LDLR(4), LIPC(1), LRP1(15), SCARB1(1), SOAT1(2) 10040960 32 21 29 9 5 5 12 5 4 1 0.37 1.00 200 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 75 AIFM1(4), AKT1(1), AKT2(1), AKT3(1), APAF1(1), ATM(7), BCL2(3), BIRC2(1), BIRC3(1), CAPN1(5), CAPN2(1), CASP6(1), CHUK(4), CSF2RB(4), DFFA(1), DFFB(3), IKBKB(2), IL1R1(2), IL1RAP(2), IRAK1(2), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RIPK1(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(5), TRAF2(2) 30829292 105 53 104 37 33 17 20 25 10 0 0.37 1.00 201 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(3), BCMO1(2), RDH5(1) 1582419 10 5 10 1 3 5 1 0 1 0 0.38 1.00 202 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(2), GOT1(1), PAH(1), TAT(3), YARS(2) 3374325 10 9 10 4 4 2 2 2 0 0 0.38 1.00 203 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(3), GALNT2(4), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), ST3GAL1(2), WBSCR17(7) 5757903 29 15 29 14 15 4 6 1 3 0 0.38 1.00 204 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(1), ABLIM2(1), ABLIM3(2), CFL2(1), DCC(9), DPYSL2(2), DPYSL5(2), EFNA3(2), EFNA5(2), EFNB1(2), EFNB2(2), EFNB3(1), EPHA1(6), EPHA2(2), EPHA3(2), EPHA4(3), EPHA5(4), EPHA6(2), EPHA7(6), EPHA8(6), EPHB1(10), EPHB2(6), EPHB3(1), EPHB4(2), EPHB6(5), FES(3), GNAI2(1), GSK3B(1), KRAS(1), L1CAM(7), LIMK1(1), LIMK2(1), LRRC4C(3), MAPK1(3), MAPK3(2), MET(5), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), NRP1(5), NTN1(3), NTN4(2), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLXNA1(3), PLXNA2(8), PLXNA3(3), PLXNB1(3), PLXNB3(7), PLXNC1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTK2(2), RGS3(2), RHOA(1), RHOD(1), RND1(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(4), SEMA3A(1), SEMA3B(1), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(3), SEMA4G(3), SEMA5A(2), SEMA5B(2), SEMA6B(1), SEMA6C(1), SEMA7A(1), SLIT1(4), SLIT2(5), SLIT3(14), SRGAP1(5), SRGAP2(2), SRGAP3(4), UNC5A(4), UNC5D(2) 73879908 254 115 250 87 71 45 52 49 37 0 0.38 1.00 205 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), MAPK1(3), MAPK3(2), MYT1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SRC(2) 7939238 31 19 31 7 14 3 5 6 3 0 0.38 1.00 206 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 13 CD8A(1), EPO(1), IL2(1), IL4(1), IL6(2), IL7(1) 2026590 7 6 7 1 3 1 0 2 1 0 0.38 1.00 207 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(4), PC(3), PDHA1(1), SLC25A11(3) 3635305 13 9 13 5 3 1 4 4 1 0 0.38 1.00 208 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(6), LPO(1), MPO(3), MTHFR(3), SHMT2(1), TPO(4) 4632196 18 13 18 9 12 0 2 1 3 0 0.39 1.00 209 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), AKT2(1), AKT3(1), BCL2(3), BCR(1), BLNK(2), BTK(1), CD19(2), CD22(5), CR2(6), DAG1(2), FLOT1(2), GSK3B(1), INPP5D(6), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NR0B2(3), PIK3CD(2), PLCG2(11), PPP3CB(1), PTPRC(4), SOS1(1), SOS2(4), SYK(2), VAV1(6) 27675255 108 53 107 32 43 14 20 16 15 0 0.39 1.00 210 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TAL1(1), TALDO1(1), TKT(2) 8108679 38 20 38 7 16 7 3 8 4 0 0.39 1.00 211 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(3), GREB1(2), MTA1(4), MTA3(2), PDZK1(1), TUBA8(4) 4036321 18 10 18 7 7 2 5 1 3 0 0.39 1.00 212 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6464244 27 16 27 8 9 6 8 1 3 0 0.39 1.00 213 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3E(1), CD3G(1), CXCR3(2), ETV5(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), JAK2(4), MAPK14(1), STAT4(1), TYK2(3) 7214838 26 17 25 11 11 1 7 2 5 0 0.39 1.00 214 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(9), ACY3(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AMDHD1(3), AOC2(2), AOC3(2), CARM1(1), CNDP1(4), DDC(1), FTCD(3), HAL(2), HARS(3), HARS2(1), HDC(3), HNMT(1), LCMT1(1), MAOB(1), PRMT7(2), PRMT8(1), PRPS2(2), UROC1(2) 15524197 56 36 56 17 29 5 6 14 2 0 0.40 1.00 215 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(1), ABP1(9), ACMSD(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), KYNU(3), MAOB(1), SDS(4), TDO2(2), TPH1(3) 21968333 88 44 86 22 36 13 20 14 5 0 0.40 1.00 216 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDPS(2), HMGCR(1), LSS(1), MVD(1), MVK(1), NQO2(1), PMVK(1), SC5DL(2), SQLE(1) 4352042 15 10 14 1 6 0 3 3 3 0 0.40 1.00 217 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(3), ACVR1C(2), ACVR2B(1), ACVRL1(2), AMHR2(3), BMP5(3), BMP6(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CDKN2B(1), COMP(1), CREBBP(8), CUL1(5), DCN(2), EP300(5), FST(2), GDF5(2), GDF6(1), GDF7(1), ID1(1), IFNG(1), INHBA(3), INHBB(2), INHBE(1), LEFTY1(5), LEFTY2(2), LTBP1(1), MAPK1(3), MAPK3(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(3), RBL2(1), RHOA(1), ROCK1(3), ROCK2(4), RPS6KB1(1), SMAD3(1), SMAD4(1), SMAD7(1), SMAD9(1), SMURF1(6), SP1(6), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), THBS1(3), THBS2(5), THBS3(1), THBS4(2), ZFYVE16(2), ZFYVE9(2) 38984308 131 61 130 36 32 26 31 23 18 1 0.40 1.00 218 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ACADVL(3), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CPT2(1), CYP4A11(3), CYP4A22(4), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1) 19720139 63 39 61 16 23 4 14 12 10 0 0.41 1.00 219 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(1), GOT1(1), PAH(1), TAT(3), YARS(2), YARS2(2) 3538569 11 9 11 2 2 4 3 2 0 0 0.41 1.00 220 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(5), AMY2B(1), ENPP3(1), G6PC(2), GAA(3), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), MGAM(7), PGM3(2), PYGB(4), PYGL(1), PYGM(2), SI(3), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UXS1(1) 21856473 66 42 64 30 30 8 12 9 7 0 0.42 1.00 221 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(2), ACP6(2), ACPT(3), ENPP3(1), LHPP(1), MTMR1(2), MTMR2(3), RFK(1), TYR(5) 6011045 20 12 20 5 4 4 4 6 2 0 0.42 1.00 222 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(1), BCL2(3), CABIN1(12), CALM1(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(2), CREBBP(8), CSNK2A1(3), EGR2(3), EGR3(4), EP300(5), FCER1A(3), FCGR3A(1), FOS(1), GATA3(2), GATA4(2), GRLF1(4), GSK3B(1), IFNB1(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), IL6(2), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(3), P2RX7(2), PAK1(2), PPP3CB(1), PPP3R1(1), PTPRC(4), SLA(1), SP1(6), SP3(1), TGFB1(1), TRAF2(2), VAV1(6), VAV2(3), VAV3(2), XPO5(1) 34487562 127 56 127 37 33 21 31 18 23 1 0.42 1.00 223 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), CHUK(4), GH1(1), GHR(3), NFKB1(1), NFKBIA(2), PPP2CA(1) 4158788 13 10 12 4 3 2 2 4 2 0 0.42 1.00 224 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLUD2(4) 1683449 7 5 7 2 3 0 3 0 1 0 0.42 1.00 225 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), BIRC3(1), DFFA(1), DFFB(3), GZMB(3), PRF1(3), SCAP(5), SREBF1(2), SREBF2(3) 7117067 23 16 23 9 8 1 4 4 6 0 0.43 1.00 226 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 88 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRB1(1), DRD1(2), DRD2(1), EGF(3), GJA1(1), GNA11(2), GNAI2(1), GNAQ(1), GNAS(3), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(2), MAPK7(3), NPR2(1), NRAS(1), PDGFC(3), PDGFD(2), PDGFRB(5), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKG2(5), PRKX(2), SOS1(1), SOS2(4), SRC(2), TJP1(2), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 49674282 177 83 173 69 69 22 33 26 26 1 0.44 1.00 227 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(3), INSR(5), IRS1(4), JAK2(4), MAP2K1(1), MAPK1(3), MAPK3(2), PLCG1(3), PRKCA(3), PTPN6(4), SLC2A4(3), SOCS1(1), SOS1(1), SRF(2), STAT5A(2), STAT5B(2) 11643369 44 26 43 13 16 7 8 10 3 0 0.44 1.00 228 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(1), CCND2(1), CCNE1(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), RBL1(3) 5489046 17 12 17 8 1 4 5 2 5 0 0.44 1.00 229 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(8), GNAS(3), GNB1(1), GNGT1(1) 2556429 13 10 13 4 7 1 3 1 1 0 0.44 1.00 230 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(6), GLS(3), GOT1(1) 3019519 10 7 10 2 2 2 4 1 1 0 0.44 1.00 231 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(3), AGTR1(2), AGTR2(1), COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), REN(2) 10340714 39 23 37 11 13 11 6 5 4 0 0.44 1.00 232 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), CALM1(1), ELK1(1), FCER1A(3), FCER1G(1), FOS(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLA2G4A(4), PLCG1(3), PPP3CB(1), SOS1(1), SYK(2), SYT1(1), VAV1(6) 15627890 46 30 46 23 9 10 8 12 6 1 0.44 1.00 233 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 24 AKT1(1), AKT2(1), AKT3(1), BCL2(3), GSK3B(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), MAP4K1(1), MAPK1(3), MAPK3(2), PIK3CD(2), SOCS1(1), SOS1(1), SOS2(4), STAT6(3) 12602564 41 27 40 11 14 4 9 11 3 0 0.44 1.00 234 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(1) 2728774 9 7 9 6 2 1 3 2 1 0 0.44 1.00 235 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NGFR(1) 3196853 11 8 11 2 4 1 2 3 1 0 0.45 1.00 236 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS2(2), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PGM3(2), PKLR(4) 22858971 92 46 91 21 41 12 15 16 8 0 0.45 1.00 237 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(1), IFNGR2(1), JAK1(3), JAK2(4), STAT1(1) 3343293 11 8 10 0 6 0 1 2 2 0 0.45 1.00 238 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(4) 1930467 7 5 7 2 0 1 1 4 1 0 0.45 1.00 239 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), ARHGDIB(4), CASP1(4), GZMB(3), PRF1(3) 5217895 17 11 17 7 3 4 2 4 4 0 0.45 1.00 240 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(2), ALAS2(1), CPOX(1), FECH(3), HMBS(1), PPOX(2), UROD(1), UROS(1) 3096938 12 8 12 1 2 1 3 3 3 0 0.46 1.00 241 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(9), AGXT2(2), AKR1B10(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PHGDH(1), PIPOX(2), PISD(3), PSPH(2), RDH13(1), SARS2(2), SDS(4), SHMT2(1), TARS(2), TARS2(1) 16579849 62 35 61 15 23 14 12 7 6 0 0.46 1.00 242 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(9), ACOT12(1), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4) 18815701 65 37 65 20 22 6 16 13 8 0 0.46 1.00 243 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(1), ALDOC(3), DERA(2), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKT(2), TKTL1(2), TKTL2(2) 9580655 43 22 43 7 18 6 6 8 5 0 0.47 1.00 244 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(8), ADRB2(1), CFTR(7), GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5000185 22 13 22 6 11 3 4 2 2 0 0.47 1.00 245 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(2), ACADS(4), ACADVL(3), ACSL3(3), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1) 6771058 20 13 20 4 6 3 4 5 2 0 0.48 1.00 246 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCR3(2), HLA-DRA(1), HLA-DRB1(2), IL4(1), IL5RA(1), IL6(2) 1808654 9 5 9 1 2 3 0 2 2 0 0.48 1.00 247 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ADC(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EARS2(2), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GFPT2(2), GLS(3), GLUD2(4), GLUL(1), GMPS(1), GOT1(1), GSR(1), GSS(1), NADSYN1(4), NAGK(2), QARS(3) 15751750 59 32 59 13 14 9 15 17 3 1 0.48 1.00 248 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(1), LEPR(1), PRKAA2(1), PRKAG1(2), PRKAG2(5) 5919449 18 12 18 3 8 1 5 1 3 0 0.49 1.00 249 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1), MASP1(2), MBL2(1) 8383457 30 18 29 23 9 3 8 7 2 1 0.49 1.00 250 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3) 2740861 9 8 9 4 5 0 0 1 3 0 0.49 1.00 251 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSS(1), GSTA1(2), GSTA4(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1) 6880063 26 15 25 6 11 2 6 6 1 0 0.49 1.00 252 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(2), GAD1(4), GAD2(3), GGT1(2) 2278836 12 6 12 2 4 3 2 3 0 0 0.49 1.00 253 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(1), IL12B(1), IL16(4), IL2(1), IL4(1), IL6(2) 3964825 11 8 11 5 2 1 2 4 2 0 0.49 1.00 254 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(3), ADCY9(5), AK1(1), ARF4(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), GNAS(3), PLCG1(3), PLCG2(11), PRKCA(3), SEC61A1(1), TRIM23(1) 14879216 59 32 59 22 24 11 12 5 7 0 0.49 1.00 255 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1) 4061066 14 9 14 4 5 4 1 0 4 0 0.49 1.00 256 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1C1(3), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(7) 12995770 54 29 54 22 27 5 9 3 10 0 0.50 1.00 257 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(5), ESR1(3), ESR2(1), ESRRA(2), NPM1(1), NR1D1(3), NR1H2(1), NR1H3(1), NR1I3(2), NR2F2(2), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(2), NR5A1(1), NR5A2(1), PGR(4), PPARA(1), RARG(2), ROR1(2), RORA(1), RORC(3), RXRA(3), RXRB(1), RXRG(1), THRA(1), VDR(2) 15986444 51 33 49 27 16 2 10 12 11 0 0.51 1.00 258 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAS1(2), ALAS2(1), CPO(3), FECH(3), GATA1(1), HMBS(1), UROD(1), UROS(1) 3207720 13 7 13 2 2 3 2 4 2 0 0.51 1.00 259 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(4), DNAJC3(3), EIF2S2(1), MAP3K14(2), NFKB1(1), NFKBIA(2) 3587258 13 7 12 4 1 1 3 5 3 0 0.51 1.00 260 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PAK1(2) 5856060 16 13 16 5 1 4 4 4 3 0 0.51 1.00 261 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), SQLE(1) 1248932 3 3 3 0 1 0 0 2 0 0 0.52 1.00 262 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(4), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2) 4233734 15 10 15 9 5 1 4 2 3 0 0.52 1.00 263 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), ESCO1(2), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(4) 13787304 54 32 54 11 25 7 5 11 6 0 0.52 1.00 264 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(4), MAP3K14(2), MAPK14(1), NFKB1(1), TNFRSF13B(2), TNFSF13B(2), TRAF2(2), TRAF3(3), TRAF5(1) 5745691 18 12 17 6 4 0 4 7 3 0 0.52 1.00 265 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), CCL5(1), CHUK(4), CXCL1(1), F11R(1), GIT1(2), IKBKB(2), JAM2(1), JAM3(1), LYN(1), MAP3K14(2), MAPK13(1), MAPK14(1), MAPK9(2), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(11), PTPN11(6), PTPRZ1(3), SRC(2), TCIRG1(2), TJP1(2) 26992127 94 46 93 39 30 14 20 19 11 0 0.52 1.00 266 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CALM1(1), CCL2(2), FOS(1), GNAQ(1), MAPK14(1), PLCG1(3), PRKCA(3), PTK2B(1), SYT1(1) 5281234 14 11 14 9 3 2 2 6 1 0 0.53 1.00 267 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(1), ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(3), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SGMS1(1), SGMS2(1), SMPD3(1), SPHK1(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(2) 13471713 44 28 43 18 16 8 4 5 10 1 0.53 1.00 268 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(3), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFKB1(1), NSMAF(3), RIPK1(1), TNFRSF1A(2), TRAF2(2) 8274482 23 18 23 7 5 4 4 5 5 0 0.53 1.00 269 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12B(1), ALOX15(2), ALOX15B(1), ALOX5(1), CBR1(1), CBR3(2), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP4A11(3), CYP4A22(4), CYP4F2(5), CYP4F3(5), EPHX2(2), GGT1(2), GPX1(2), GPX2(1), GPX5(2), LTA4H(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3) 15372562 67 33 66 28 31 6 15 9 5 1 0.53 1.00 270 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(2), IL10RA(1), IL6(2), JAK1(3), STAT1(1), STAT3(2), STAT5A(2) 4931464 15 10 15 4 4 2 2 3 4 0 0.54 1.00 271 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(2), ACADS(4), ECHS1(1), HADHA(1) 2142674 8 5 8 2 3 1 2 1 1 0 0.54 1.00 272 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT2(1), AKT3(1), CDKN1A(1), ELK1(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(2), SOS1(1) 5448617 15 12 15 6 6 3 1 3 2 0 0.54 1.00 273 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(6), HLA-DRA(1), HLA-DRB1(2), ITGAL(4), ITGB2(5), PTPRC(4) 5799042 27 11 26 13 6 6 7 1 7 0 0.54 1.00 274 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 19 ADCY1(8), AKT1(1), BCL2(3), CSF2RB(4), IGF1R(2), KIT(3), KITLG(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 6807436 26 17 26 5 11 3 6 4 2 0 0.54 1.00 275 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(1), CERK(1), CREB3(1), CREB5(1), DAG1(2), EPHB2(6), FOS(1), GNAQ(1), ITPKB(2), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2) 11048405 40 24 40 11 12 4 10 9 5 0 0.54 1.00 276 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(1), ANXA5(1), CYP11A1(1), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(4), PRL(3), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS1(2), SCGB1A1(1), TBXAS1(3) 8177226 31 16 31 9 9 6 3 8 4 1 0.54 1.00 277 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(2), ELOVL5(1), FADS1(1), FADS2(1), FASN(7), HADHA(1), PECR(1), SCD(2) 5319808 20 12 20 3 6 3 4 4 3 0 0.54 1.00 278 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1) 4066968 13 10 12 1 7 1 2 3 0 0 0.55 1.00 279 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2), GNAQ(1), ITPKB(2) 2334197 6 6 6 1 2 0 0 2 2 0 0.56 1.00 280 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(1), AKT2(1), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(2), DAG1(2), EPHB2(6), ITPKB(2), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PIK3CD(2), PLCG2(11), SOS1(1), SOS2(4), SYK(2), VAV1(6) 19051693 67 36 67 28 25 11 11 12 8 0 0.56 1.00 281 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(4), IFNG(1), IKBKB(2), IL2(1), IL4(1), MAP3K1(5), MAP3K5(1), MAPK14(1), NFKB1(1), NFKBIA(2), TNFSF9(3), TRAF2(2) 7816794 25 15 24 13 8 2 3 7 5 0 0.56 1.00 282 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 10 CCNE1(1), CDKN1B(3), CUL1(5) 2609413 9 7 9 3 2 2 2 0 3 0 0.56 1.00 283 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GLS(3), GLUL(1), GMPS(1), GOT1(1), GSS(1), NADSYN1(4), QARS(3) 13204749 46 26 46 9 10 9 11 13 3 0 0.56 1.00 284 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(3), IL22RA1(1), JAK1(3), JAK2(4), JAK3(4), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), TYK2(3) 7302229 26 16 24 6 12 2 6 5 1 0 0.56 1.00 285 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(3), DHCR7(4), FDPS(2), GGCX(1), HMGCR(1), HSD17B7(1), IDI2(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1), TM7SF2(2) 7681268 26 16 25 7 8 2 7 3 6 0 0.56 1.00 286 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(1), ABL2(1), AKT1(1), AKT2(1), AKT3(1), ARAF(1), AREG(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CBL(1), CBLB(1), CBLC(1), CDKN1A(1), CDKN1B(3), EGF(3), ELK1(1), ERBB2(7), ERBB3(4), ERBB4(1), GAB1(1), GSK3B(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK9(2), NRAS(1), NRG1(4), NRG2(1), NRG3(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SRC(2), STAT5A(2), STAT5B(2), TGFA(2) 37720762 123 61 121 45 46 14 22 26 15 0 0.57 1.00 287 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(7), CDC25B(1), MYT1(7) 5167848 15 9 15 0 5 3 2 2 3 0 0.57 1.00 288 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT2(1), AKT3(1), BPNT1(1), ILK(2), MAPK1(3), MAPK3(2), PIK3CD(2), PTK2B(1), RBL2(1), SOS1(1) 6879113 16 13 16 6 4 2 3 6 1 0 0.58 1.00 289 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), IMPDH1(2), OAZ1(1), POLD1(3), POLG(4), PRPS2(2), RRM1(2) 4959256 15 10 14 6 4 2 3 3 3 0 0.58 1.00 290 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(1), CAPN1(5), CAPN10(2), CAPN11(1), CAPN2(1), CAPN3(2), CAPN5(1), CAPN6(5), CAPNS1(1), CAV1(1), CAV3(1), DOCK1(9), GIT2(2), ILK(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK6(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PIK3R2(5), PTK2(2), PXN(1), RAP1B(2), RHO(1), ROCK1(3), ROCK2(4), SEPP1(1), SHC3(1), SORBS1(2), SOS1(1), SRC(2), TLN1(6), TNS1(5), VASP(2), VAV2(3), VAV3(2), VCL(2), ZYX(2) 52505328 182 77 181 71 69 23 38 27 25 0 0.58 1.00 291 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(1), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(4), GRIA3(5), GRID2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IGF1R(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NOS1(9), NOS3(5), NPR2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(3), PRKCG(1), PRKG2(5), RYR1(14) 42481798 158 70 154 62 66 21 27 21 21 2 0.58 1.00 292 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CUL1(5), FBXW7(2) 2642751 8 7 8 4 3 1 2 0 2 0 0.58 1.00 293 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(5), MYL2(2), MYLK(7), PAK1(2), PPP1R12B(6), RALBP1(3), RPS6KB1(1), TRIO(8), VAV1(6), WASF1(1) 11688440 44 24 44 16 13 6 13 7 5 0 0.59 1.00 294 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), B4GALT2(1), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GANC(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2), RDH13(1), UGP2(1) 15097310 59 32 55 14 30 5 11 8 5 0 0.59 1.00 295 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAR2A(1), PRKAR2B(1) 5958974 25 15 25 6 12 1 6 4 2 0 0.59 1.00 296 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(3), CHUK(4), DAXX(4), EGF(3), FOS(1), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), RIPK1(1), SP1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 18655627 67 36 66 25 16 10 16 15 10 0 0.59 1.00 297 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT4(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GCNT2(1), ST3GAL6(2) 6100494 22 13 22 9 8 3 4 6 1 0 0.60 1.00 298 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(9), ACY1(1), ADC(2), AGMAT(1), ALDH18A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CPS1(6), GATM(2), MAOB(1), ODC1(1), OTC(2), SAT1(1), SAT2(1) 11918551 43 25 43 9 13 10 8 12 0 0 0.60 1.00 299 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(1), ALDOC(3), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GAPDHS(2), GCK(2), GOT1(1), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6B(1), LDHC(1), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PKLR(4) 16619362 68 32 67 20 26 11 11 13 7 0 0.60 1.00 300 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(2), ACPT(3), ENPP3(1), RFK(1), TYR(5) 3874593 12 7 12 4 2 2 2 5 1 0 0.60 1.00 301 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3), ERBB3(4), NRG1(4) 3105556 11 7 11 2 4 0 3 3 1 0 0.61 1.00 302 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ABAT(2), ACADS(4), ACSM1(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(1), RDH13(1) 16399088 52 31 52 20 18 7 10 9 8 0 0.61 1.00 303 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 ACTR3(2), AKT1(1), ANGPTL2(2), DAG1(2), GCA(1), ITGA9(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), MAP2K1(1), MAPK1(3), MAPK3(2), NR1I3(2), PAK1(2), PDE3A(1), PDE3B(4), PIK3CD(2), PLDN(1), PSME1(1), RIPK3(2), RPS4X(1), VASP(2) 16749545 64 34 64 17 18 11 14 10 11 0 0.61 1.00 304 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(1), B4GALT2(1), DDOST(2), DPAGT1(1), FUT8(1), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), RPN1(1), ST6GAL1(4) 7750835 24 15 24 5 6 5 3 5 5 0 0.62 1.00 305 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), EIF4E(2), FBL(1), LDHA(2), LDHC(1), MAPK14(1), NCL(3) 3536753 14 7 14 3 4 1 1 5 3 0 0.62 1.00 306 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(3), BTK(1), CFL2(1), INPPL1(4), ITPR1(7), ITPR2(11), ITPR3(11), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CD(2), PIK3CG(12), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), WASF1(1) 25865054 89 45 89 31 34 13 19 10 13 0 0.62 1.00 307 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 3235255 15 8 15 3 5 5 3 2 0 0 0.62 1.00 308 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 3235255 15 8 15 3 5 5 3 2 0 0 0.62 1.00 309 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 653274 2 2 2 0 0 1 1 0 0 0 0.63 1.00 310 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), NTRK1(4), PLCG1(3), PRKCA(3), SOS1(1) 4715254 12 10 12 7 3 3 2 4 0 0 0.63 1.00 311 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(1), UXS1(1) 1560555 5 3 5 0 2 2 0 1 0 0 0.63 1.00 312 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(2), HLA-DRA(1), HLA-DRB1(2) 1233437 6 3 6 0 0 3 0 2 1 0 0.63 1.00 313 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(8), FSHR(1), GNAS(3), XPO1(2) 3767123 14 10 14 3 8 1 3 1 1 0 0.64 1.00 314 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), IL4(1) 1253980 6 3 6 0 2 2 0 2 0 0 0.64 1.00 315 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), ESRRA(2), HDAC5(4), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CB(1), SLC2A4(3), SYT1(1) 8008658 25 16 25 7 4 4 6 7 4 0 0.64 1.00 316 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(9), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), AKT1(1), AKT2(1), AKT3(1), CAMKK1(3), CAMKK2(1), CD36(2), CHUK(4), CPT1A(1), CPT1C(2), CPT2(1), G6PC(2), IKBKB(2), IRS1(4), IRS4(3), JAK1(3), JAK2(4), JAK3(4), LEPR(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK1(4), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKCQ(1), PTPN11(6), RXRA(3), RXRB(1), RXRG(1), SLC2A1(4), SLC2A4(3), STAT3(2), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2), TYK2(3) 32767225 117 54 112 39 42 14 23 19 19 0 0.64 1.00 317 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), ENPP2(5), PAFAH2(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLD2(1), PPAP2C(1) 9229215 32 19 32 17 13 3 4 5 6 1 0.64 1.00 318 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 IFNG(1), IFNGR1(1), JAK1(3), JAK2(4), PTPRU(3), STAT1(1) 4512928 13 10 12 1 9 0 1 1 2 0 0.65 1.00 319 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(2), VAMP2(1) 1301392 3 3 3 1 2 0 0 0 1 0 0.65 1.00 320 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 NRF1(2), TAX1BP3(1), UBE2A(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE3A(4) 4005221 12 7 12 1 3 2 3 1 2 1 0.65 1.00 321 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(6), LPO(1), MPO(3), PRDX2(2), SHMT2(1), TPO(4) 4676705 17 11 17 9 11 0 2 1 3 0 0.66 1.00 322 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(8), CALM1(1), ELK1(1), FOS(1), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), MAP2K1(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RPS6KA3(5), SYT1(1) 13613042 43 27 43 15 12 6 8 12 5 0 0.66 1.00 323 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(2) 827895 2 2 2 2 1 0 1 0 0 0 0.66 1.00 324 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG2(2), ACTR3(2), AKT1(1), ANGPTL2(2), CFL2(1), FLNA(14), FLNC(6), FSCN3(2), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), VASP(2), WASF1(1) 16803805 59 33 59 19 20 7 15 8 9 0 0.66 1.00 325 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(2), EGF(3), HGS(3), TFRC(2) 4056839 10 7 10 4 0 2 2 3 3 0 0.66 1.00 326 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(1), CREBBP(8), EP300(5), ERCC3(2), ESR1(3), GRIP1(6), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), MEF2C(1), NCOR2(5), NRIP1(3), PELP1(2), POLR2A(2), TBP(2) 18281204 59 34 59 14 19 7 18 6 8 1 0.66 1.00 327 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK1(3), MAPK3(2), SOS1(1) 5980178 14 12 14 3 4 3 1 5 1 0 0.66 1.00 328 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 26 HLA-DRA(1), HLA-DRB1(2), IFNB1(1), IFNG(1), IL12B(1), IL2(1), IL4(1), IL6(2), IL7(1), TGFB1(1), TGFB2(1) 4819639 13 9 13 4 2 3 1 3 4 0 0.66 1.00 329 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(2), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), MAPK8IP3(5), PAPPA(6), RPS6KA3(5), SOS1(1), SYK(2), VAV1(6), VAV2(3), VAV3(2) 12633746 48 26 48 14 18 9 9 8 4 0 0.66 1.00 330 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB3(1), CREB5(1), MAPK1(3), SNX13(1), SRC(2), TERF2IP(3) 3828054 12 7 12 1 2 2 3 5 0 0 0.66 1.00 331 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(7), AXIN1(2), CCND2(1), DVL2(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LDLR(4), MAPK9(2), PLAU(2), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), RHOA(1), TCF7(3), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT4(3), WNT5A(1) 23140736 82 43 79 26 27 7 18 14 16 0 0.67 1.00 332 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(8), ACACB(9), ACADM(2), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLA2(1), SUCLG1(2) 16123336 52 29 52 13 16 7 13 8 8 0 0.67 1.00 333 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(1), CD28(1), DAG1(2), EPHB2(6), FBXW7(2), GRAP2(1), ITPKB(2), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLCG1(3), PTPRC(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(1), SOS2(4), VAV1(6), ZAP70(5) 21140684 73 38 73 27 25 11 12 13 12 0 0.67 1.00 334 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(4), BIRC2(1), BIRC3(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), DFFA(1), DFFB(3), GZMB(3), LMNB1(1), LMNB2(3), PRF1(3) 7723788 28 16 28 7 4 5 5 8 6 0 0.67 1.00 335 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSR(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1) 8192219 30 16 29 7 14 2 7 6 1 0 0.67 1.00 336 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(3), ELK1(1), FOS(1), INSR(5), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SLC2A4(3), SOS1(1), SRF(2) 8615025 29 17 29 8 8 6 5 6 4 0 0.67 1.00 337 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 9 ATM(7), CDC25B(1), MYT1(7) 5677758 15 9 15 1 5 3 2 2 3 0 0.68 1.00 338 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 44 ACOX1(2), APOA2(1), CD36(2), CREBBP(8), EHHADH(2), EP300(5), HSD17B4(1), MAPK1(3), MAPK3(2), ME1(4), MRPL11(1), NCOA1(3), NCOR1(5), NCOR2(5), NFKBIA(2), NR0B2(3), NR1H3(1), NRIP1(3), PPARA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RXRA(3), SP1(6), STAT5A(2), STAT5B(2) 22308002 73 38 73 24 18 7 19 17 10 2 0.68 1.00 339 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP2E1(4), NR1I3(2), PTGS1(2) 2149083 8 5 8 5 3 0 3 1 1 0 0.68 1.00 340 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), BCL2(3), DAXX(4), MAPKAPK2(1), MAPKAPK3(1) 4559228 11 9 11 4 2 1 4 2 2 0 0.68 1.00 341 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR2(2), SNAP23(1), SNAP25(2), SNAP29(1), STX11(1), STX19(1), STX2(1), STX3(1), STX4(1), STX5(2), STX7(1), STX8(1), TSNARE1(2), USE1(1), VAMP2(1), VAMP5(1) 6371131 20 12 20 7 6 3 1 5 5 0 0.69 1.00 342 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP12A(5), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), ATP7B(3), COX10(1), COX8A(1), NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2), PPA2(1), UQCRC1(3) 14093507 52 27 52 15 14 11 13 7 7 0 0.69 1.00 343 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(2) 1249454 4 3 4 2 1 1 0 0 2 0 0.69 1.00 344 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4) 2470997 8 5 8 5 2 1 1 3 1 0 0.70 1.00 345 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(4), FDPS(2), HMGCR(1), HMGCS1(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1) 5222852 16 9 15 3 5 0 5 3 3 0 0.70 1.00 346 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 3135228 8 6 8 4 0 3 1 1 3 0 0.70 1.00 347 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI2(1), SQLE(1) 1690221 4 3 4 0 1 0 0 2 1 0 0.70 1.00 348 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(1), BCL2(3), IGF1R(2), POLR2A(2), PPP2CA(1), PRKCA(3), TEP1(4), TERT(8), TNKS(4), XRCC5(1) 9171493 29 19 27 4 12 3 6 4 4 0 0.70 1.00 349 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(1), ACTA2(2), ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF2(1), ATF4(1), ATP2A2(2), ATP2A3(4), CACNB3(1), CALCA(3), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CNN2(1), CORIN(5), CREB3(1), CRHR1(2), DGKZ(5), FOS(1), GABPA(1), GJA1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), GSTO1(3), GUCA2B(1), GUCY1A3(5), IGFBP1(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(7), ITPR2(11), ITPR3(11), MIB1(2), MYL2(2), MYLK2(1), NFKB1(1), NOS1(9), NOS3(5), OXTR(2), PDE4B(1), PDE4D(3), PLCB3(5), PLCD1(1), PLCG1(3), PLCG2(11), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RAMP3(2), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SP1(6), TNXB(6), USP5(5), YWHAB(1) 64122809 255 100 250 85 106 32 48 38 31 0 0.70 1.00 350 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), SOAT2(2) 9397592 38 19 38 9 16 10 8 4 0 0 0.71 1.00 351 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(1), AFMID(3), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1) 5436982 14 11 14 7 7 1 4 2 0 0 0.71 1.00 352 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1) 4578927 13 10 12 2 7 1 2 3 0 0 0.72 1.00 353 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(2), EP300(5), EPO(1), HIF1A(1), LDHA(2), NOS3(5), VHL(1) 6659170 18 11 18 9 4 0 5 6 2 1 0.72 1.00 354 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(3), CREBBP(8), EP300(5), IL7(1), IL7R(1), JAK1(3), JAK3(4), PTK2B(1), STAT5A(2), STAT5B(2) 9753607 30 18 29 12 6 5 11 4 3 1 0.72 1.00 355 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(7), APC2(2), AXIN1(2), AXIN2(1), BTRC(1), CACYBP(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CCND2(1), CHD8(9), CREBBP(8), CSNK2A1(3), CTBP1(3), CTBP2(4), CUL1(5), CXXC4(2), DAAM1(1), DAAM2(1), DKK1(1), DKK2(3), DVL2(2), EP300(5), FBXW11(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NKD2(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PORCN(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RHOA(1), ROCK1(3), ROCK2(4), RUVBL1(1), SENP2(2), SFRP1(2), SFRP5(1), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(1), TBL1Y(1), TCF7(3), TCF7L2(3), VANGL1(2), VANGL2(1), WIF1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4) 62651521 220 89 216 70 67 26 53 40 32 2 0.72 1.00 356 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP5(3), BMP6(3), BTRC(1), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(2), GLI1(4), GLI2(8), GLI3(3), GSK3B(1), HHIP(4), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(2), SHH(2), SMO(2), STK36(2), SUFU(2), WNT10A(1), WNT11(1), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4), ZIC2(1) 19902847 81 40 80 40 26 21 15 9 10 0 0.72 1.00 357 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FOS(1), MAPK14(1), THBS1(3) 2982491 7 6 7 4 1 2 0 3 1 0 0.72 1.00 358 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(2), AGXT2(2), ASNS(1), CAD(6), GAD1(4), GAD2(3), GOT1(1), NARS(1), PC(3) 10342147 26 19 26 13 5 5 7 6 3 0 0.73 1.00 359 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(3), KARS(4) 2839594 9 5 9 3 0 2 1 4 2 0 0.73 1.00 360 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 3366834 9 6 9 3 1 3 1 1 3 0 0.73 1.00 361 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B2(2) 3278617 8 6 8 6 2 0 4 0 2 0 0.73 1.00 362 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(5) 7433431 23 14 23 7 7 4 3 4 5 0 0.74 1.00 363 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(7), ATR(9) 5823225 16 9 16 3 4 4 2 4 2 0 0.74 1.00 364 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(3), CREBBP(8), EP300(5), MAP2K1(1), MAP3K7(2), MAPK3(2), SKIL(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5) 10432659 38 18 38 9 9 6 11 6 5 1 0.74 1.00 365 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT2(1), AKT3(1), IARS(4), IL13RA1(1), IL4(1), IL4R(6), INPP5D(6), JAK1(3), JAK2(4), JAK3(4), NR0B2(3), RPS6KB1(1), SOS1(1), SOS2(4), SRC(2), STAT6(3), TYK2(3) 13804452 49 27 47 15 22 10 6 7 4 0 0.74 1.00 366 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CD3E(1), CD3G(1), ELK1(1), FOS(1), MAP2K1(1), MAP3K1(5), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYT1(1), VAV1(6), ZAP70(5) 17550822 43 30 43 25 11 7 9 9 7 0 0.74 1.00 367 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(1), MMP9(2), RECK(1), TIMP3(2) 3004129 10 7 10 1 5 1 2 1 1 0 0.74 1.00 368 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), B3GNT1(2), FUT1(1), FUT9(1), GCNT2(1) 2428650 7 5 7 3 3 1 1 1 1 0 0.74 1.00 369 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(1), CSF1R(3), EGF(3), MET(5), PRKCA(3), SH3GLB1(2), SH3GLB2(4), SH3KBP1(3), SRC(2) 5899232 26 11 26 7 8 4 5 5 4 0 0.74 1.00 370 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), NDST1(2), NDST2(2), NDST3(2), NDST4(5) 8299249 37 17 37 7 10 5 10 5 7 0 0.74 1.00 371 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(3), ELK1(1), FOS(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2) 8341991 23 16 23 7 8 4 4 5 2 0 0.75 1.00 372 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 48 ACTA1(1), AGT(3), AKT1(1), CALM1(1), CAMK1(2), CAMK4(1), CREBBP(8), ELSPBP1(1), F2(1), FGF2(1), FKBP1A(1), GATA4(2), GSK3B(1), MAP2K1(1), MAPK1(3), MAPK14(1), MAPK3(2), MEF2C(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KB1(1), SYT1(1) 16776281 45 28 45 20 5 8 11 13 8 0 0.75 1.00 373 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 28 AMDHD2(2), CHIA(2), CHIT1(1), CMAS(1), CTBS(3), GFPT1(5), GFPT2(2), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), LHPP(1), MTMR1(2), MTMR2(3), NAGK(2), PGM3(2), UAP1(1) 11119870 39 21 38 9 12 3 9 8 6 1 0.75 1.00 374 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CAMK1(2), ELK1(1), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NCF1(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PAK1(2), PLCB1(3), PPP3CB(1), SYT1(1) 14267583 44 24 44 18 7 7 10 11 8 1 0.75 1.00 375 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), DUSP14(1), EIF4E(2), IFNG(1), IL1R1(2), NR4A3(1), WDR1(2) 4340112 11 7 11 6 1 2 0 5 3 0 0.76 1.00 376 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), CNR2(3), DNMT1(5), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1) 4337739 20 9 20 8 6 2 1 8 3 0 0.76 1.00 377 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL14(1), RPL18A(2), RPL22L1(1), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL36A(1), RPL36AL(1), RPL39(1), RPL8(1), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(2), RPSA(1) 8850132 29 18 28 11 9 4 6 4 6 0 0.76 1.00 378 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(1), CREBBP(8), EP300(5), NCOA3(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RXRA(3) 7782844 24 13 24 6 5 4 7 4 3 1 0.76 1.00 379 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(1), EGF(3), MAP2K1(1), MAPK1(3), MAPK3(2), PTPRB(4), SOS1(1), SPRY1(1), SPRY2(2), SRC(2) 8602278 20 14 19 9 5 2 3 7 3 0 0.76 1.00 380 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(1), SRPR(4) 3024644 6 5 6 2 2 0 2 0 2 0 0.76 1.00 381 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(1), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1) 5187062 11 10 11 7 5 1 4 1 0 0 0.76 1.00 382 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(4), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2) 3976029 12 8 12 9 5 1 2 1 3 0 0.76 1.00 383 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(8), ADRB2(1), GNAS(3), PLCE1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5703176 22 12 22 3 9 3 4 3 3 0 0.77 1.00 384 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), GABARAPL1(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(2), PRKAA2(1), ULK1(1), ULK2(6), ULK3(1) 8181741 23 13 23 5 4 2 7 5 5 0 0.77 1.00 385 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), PAK1(2), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), SRC(2), SYT1(1) 11397828 29 20 29 13 6 5 4 10 4 0 0.77 1.00 386 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 661770 1 1 1 1 1 0 0 0 0 0 0.77 1.00 387 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG8(1), ALG9(1), B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), B4GALT7(1), C1GALT1C1(3), CHST1(2), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST2(3), CHST3(1), CHST6(1), CHST7(2), CHSY1(1), DDOST(2), DPAGT1(1), EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), FUT8(1), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), NDST1(2), NDST2(2), NDST3(2), NDST4(5), OGT(3), RPN1(1), ST3GAL1(2), ST3GAL3(1), ST6GAL1(4), ST6GALNAC1(2), UST(2), WBSCR17(7), XYLT1(3), XYLT2(1) 43749781 164 66 164 50 60 23 32 24 25 0 0.77 1.00 388 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(1), UGP2(1), UXS1(1) 1991565 6 3 6 0 2 2 1 1 0 0 0.77 1.00 389 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUD2(4), GLUL(1), HAL(2) 8479240 33 16 33 7 14 4 7 4 4 0 0.77 1.00 390 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 AKR1B10(2), ALOX15(2), ALOX5(1), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP3A4(3), CYP3A43(2), CYP3A7(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), RDH13(1) 9501740 38 17 38 13 15 2 8 8 4 1 0.77 1.00 391 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUL(1), HAL(2) 7581930 29 14 29 6 12 4 5 4 4 0 0.77 1.00 392 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(3), IRS1(4), MAPK1(3), MAPK14(1), MAPK3(2), MKNK1(1), PRKCA(3), RPS6KB1(1) 9454304 30 15 30 6 9 2 5 10 4 0 0.77 1.00 393 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2), SDS(4) 14547809 54 26 52 15 17 12 11 7 7 0 0.78 1.00 394 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(1), ACTN1(1), ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGEF7(1), CAV1(1), CDKN2A(3), CSE1L(2), DOCK1(9), EPHB2(6), GRB7(1), GRLF1(4), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PKLR(4), PLCG1(3), PLCG2(11), PTK2(2), RALA(1), RHO(1), ROCK1(3), ROCK2(4), SOS1(1), SOS2(4), SRC(2), TERF2IP(3), TLN1(6), TLN2(5), VASP(2), ZYX(2) 46250205 160 67 160 56 58 24 31 28 19 0 0.78 1.00 395 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), CDKN1B(3), ILK(2), MAPK1(3), MAPK3(2), PTK2(2), SOS1(1) 5828210 14 10 14 3 2 3 3 4 2 0 0.78 1.00 396 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(1), DLD(1), DUSP10(1), DUSP4(3), DUSP8(1), GAB1(1), GCK(2), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK7(3), MAPK9(2), NFATC3(1), PAPPA(6), ZAK(1) 19763110 55 34 53 21 23 6 7 11 8 0 0.78 1.00 397 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(1), AKT2(1), AKT3(1), BTK(1), CDKN2A(3), GSK3B(1), IARS(4), IGFBP1(1), INPP5D(6), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SOS1(1), SOS2(4), TEC(5), YWHAB(1), YWHAE(2) 13074307 42 23 42 16 13 11 5 5 8 0 0.78 1.00 398 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(1), NFKBIA(2) 4989920 15 9 13 3 6 2 3 3 1 0 0.78 1.00 399 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), CALM1(1), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK14(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYK(2), SYT1(1), VAV1(6) 15272232 40 26 40 23 9 7 8 11 5 0 0.78 1.00 400 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1) 2558268 9 7 9 1 5 1 2 1 0 0 0.78 1.00 401 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1) 2558268 9 7 9 1 5 1 2 1 0 0 0.78 1.00 402 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(3), ABCG2(2), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1) 9335101 25 17 25 16 7 5 4 4 5 0 0.78 1.00 403 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(5), CAPNS1(1), CDK5R1(1), GSK3B(1), MAPT(1), PPP2CA(1) 3492849 12 6 12 2 5 1 3 3 0 0 0.78 1.00 404 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(2), CDT1(1), DIAPH2(3), MCM10(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), NACA(7), PCNA(1), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), PRIM1(1), RFC1(3), RFC2(1), RFC3(1), RFC4(2), RFC5(1), RPA4(2), UBA52(1), UBB(1), UBC(1) 20051853 55 32 52 22 15 3 15 5 17 0 0.79 1.00 405 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(8), ARHGEF1(2), F2(1), F2RL3(1), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MAP3K7(2), PLCB1(3), PPP1R12B(6), PRKCA(3), PTK2B(1), ROCK1(3) 8809860 35 17 35 8 13 3 8 8 2 1 0.79 1.00 406 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(1), CAPN1(5), CAPN2(1), CAPNS1(1), CXCR3(2), EGF(3), ITGA1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(6) 11849096 40 21 40 11 13 3 9 12 3 0 0.79 1.00 407 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 18 ADCY1(8), AKT1(1), ASAH1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(1), MAPK1(3), MAPK3(2), PLCB1(3), PRKCA(3), PTK2(2), SPHK1(1), SRC(2) 8431125 30 17 30 6 13 5 5 4 2 1 0.79 1.00 408 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 240 ACVR1C(2), AKT1(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(4), CACNG6(1), CACNG7(1), CACNG8(1), CD14(2), CDC25B(1), CHUK(4), DAXX(4), DDIT3(1), DUSP10(1), DUSP14(1), DUSP16(1), DUSP2(2), DUSP4(3), DUSP8(1), DUSP9(1), EGF(3), ELK1(1), ELK4(1), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(14), FLNB(4), FLNC(6), FOS(1), GADD45B(1), GNA12(2), IKBKB(2), IL1R1(2), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(1), MKNK1(1), NFATC2(1), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(3), NRAS(1), NTF3(1), NTRK1(4), NTRK2(1), PAK1(2), PDGFRB(5), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PPM1B(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTPRR(2), RAP1B(2), RAPGEF2(4), RASA2(1), RASGRF1(5), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA2(2), RPS6KA3(5), RRAS2(3), SOS1(1), SOS2(4), SRF(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(2), TAOK3(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF1A(2), TRAF2(2), ZAK(1) 106096597 387 145 382 140 150 43 63 70 60 1 0.79 1.00 409 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(8), EP300(5), HDAC3(1), IKBKB(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2) 9036928 28 15 27 12 4 4 9 6 4 1 0.80 1.00 410 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1) 5466314 11 8 11 6 2 2 2 3 2 0 0.80 1.00 411 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC1(2), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1) 2977124 7 5 7 2 3 1 2 0 1 0 0.80 1.00 412 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), DOCK1(9), ELK1(1), FOS(1), GAB1(1), HGF(4), ITGA1(1), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK1(3), MAPK3(2), MET(5), PAK1(2), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), SOS1(1), SRC(2), STAT3(2) 15909130 50 28 50 10 15 8 10 13 4 0 0.80 1.00 413 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(4), CREBBP(8), EP300(5), IKBKB(2), MAP2K3(1), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), NR3C1(1), TGFBR1(1), TGFBR2(5), TLR2(4) 11876729 39 20 38 13 6 7 10 9 6 1 0.80 1.00 414 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1) 738713 1 1 1 0 1 0 0 0 0 0 0.80 1.00 415 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(1), CALM1(1), GNAS(3), GNB1(1), GNGT1(1), NFKB1(1), NOS3(5), NR3C1(1), SYT1(1) 5500194 16 10 16 8 5 2 3 3 3 0 0.80 1.00 416 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), LCT(8), NAGLU(1) 5692197 17 10 17 7 7 0 3 3 4 0 0.80 1.00 417 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(2), EPHB2(6), F2(1), F2RL3(1), MAP2K5(1), MAPK1(3), MAPK7(3), PLD2(1), PTK2(2), RASAL1(3), SRC(2), TEC(5), VAV1(6) 10846676 37 21 37 12 12 8 9 6 2 0 0.81 1.00 418 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), PDE6D(1) 1564927 4 3 4 1 0 1 2 0 1 0 0.81 1.00 419 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), MIOX(1) 3423771 9 7 9 3 4 1 2 2 0 0 0.81 1.00 420 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRA1D(1), ADRB1(1), ADRB2(1), ATP1A4(1), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1S(12), CACNB3(1), CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CASQ2(1), CHRM2(4), CHRM3(3), GJA1(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GNA11(2), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNB1(3), KCNJ3(2), KCNJ5(3), MIB1(2), NME7(3), PLCB3(5), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SLC8A3(2), USP5(5), YWHAB(1) 70176176 266 106 262 102 115 35 44 44 28 0 0.81 1.00 421 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(4), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2) 6718112 21 12 20 4 11 1 5 3 1 0 0.81 1.00 422 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2) 9862884 28 17 28 6 10 3 6 5 4 0 0.81 1.00 423 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 851992 1 1 1 2 0 1 0 0 0 0 0.81 1.00 424 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 3357368 9 6 9 6 3 2 2 2 0 0 0.81 1.00 425 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 30 AKT1(1), APC(7), ASAH1(1), CCL13(1), CCL15(1), DAG1(2), GNA11(2), GNA15(4), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), MAPK14(1), PHKA2(4), PIK3CD(2), SRC(2) 18006951 68 31 68 19 22 12 14 14 6 0 0.82 1.00 426 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(3), EGF(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2) 12542902 33 21 33 12 10 7 5 7 4 0 0.82 1.00 427 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 30 GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2F1(1), GTF2H4(1), GTF2IRD1(2), TAF1(4), TAF1L(14), TAF2(2), TAF4(2), TAF4B(1), TAF5(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(2), TAF9(1), TBPL2(2) 14193225 45 22 43 14 13 4 14 6 8 0 0.82 1.00 428 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7) 6680545 20 11 19 10 4 4 5 3 3 1 0.82 1.00 429 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(1), AKT2(1), AKT3(1), BRD4(7), CBL(1), CDKN2A(3), FLOT1(2), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), LNPEP(2), MAPK1(3), MAPK3(2), PARD3(2), PARD6A(1), PIK3CD(2), PPYR1(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SERPINB6(1), SLC2A4(3), SORBS1(2), SOS1(1), SOS2(4), YWHAB(1), YWHAE(2) 21316006 66 34 66 31 20 8 9 14 15 0 0.82 1.00 430 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(9), AOC2(2), AOC3(2), CES1(2), DDHD1(1), ESCO1(2), MYST3(4), MYST4(4), PLA1A(1), PNPLA3(1), SH3GLB1(2) 10220356 31 19 31 6 11 5 5 6 4 0 0.82 1.00 431 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(4) 3187804 5 5 3 2 0 0 0 5 0 0 0.82 1.00 432 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(3), AGTR1(2), ATF2(1), CALM1(1), ELK1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP3K1(5), MAPK1(3), MAPK3(2), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(2), PRKCA(3), PTK2(2), PTK2B(1), SOS1(1), SRC(2), SYT1(1) 12443946 36 21 36 14 8 6 9 10 3 0 0.82 1.00 433 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MYL2(2), MYLK(7), PLCB1(3), PPP1R12B(6), PRKCA(3), ROCK1(3) 8359857 33 14 33 9 10 3 10 6 3 1 0.82 1.00 434 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 197 ABI2(2), ACTN1(1), ACTN3(1), ACTN4(4), APC(7), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF4(2), ARHGEF7(1), ARPC1B(1), ARPC2(1), ARPC4(1), ARPC5L(1), BDKRB1(1), BDKRB2(3), CD14(2), CFL2(1), CHRM2(4), CHRM3(3), CYFIP1(2), CYFIP2(1), DIAPH1(2), DIAPH2(3), DIAPH3(4), DOCK1(9), EGF(3), EZR(3), F2(1), FGD1(2), FGD3(2), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FN1(3), GIT1(2), GNA12(2), GRLF1(4), GSN(2), IQGAP1(2), IQGAP2(4), IQGAP3(5), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KRAS(1), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MSN(1), MYH10(3), MYH14(6), MYH9(8), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), NCKAP1(2), NCKAP1L(4), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(6), PTK2(2), PXN(1), RHOA(1), ROCK1(3), ROCK2(4), RRAS2(3), SLC9A1(3), SOS1(1), SOS2(4), SSH1(1), SSH2(4), SSH3(2), TIAM1(2), TIAM2(8), TMSL3(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), WASF1(1), WASF2(1) 104274379 374 138 370 136 137 43 81 55 58 0 0.82 1.00 435 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADHA(1), HSD17B10(1), HSD17B4(1), MECR(2) 3446007 6 5 6 1 1 1 0 2 2 0 0.83 1.00 436 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(7), BMPR1B(1), CCND2(1), CDKN1B(3), EGR1(2), ESR2(1), FSHR(1), LHCGR(1), MSH5(3), NCOR1(5), NR5A1(1), NRIP1(3), PGR(4), PTGER2(2), VDR(2), ZP2(2) 14056328 39 23 39 12 11 5 12 4 6 1 0.83 1.00 437 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), BCL2(3), CBL(1), FOS(1), IL2RA(3), IL2RB(1), IRS1(4), JAK1(3), JAK3(4), MAPK1(3), MAPK3(2), PTPN6(4), RPS6KB1(1), SOCS1(1), SOS1(1), STAT5A(2), STAT5B(2), SYK(2) 12825362 39 23 38 12 10 4 11 10 4 0 0.83 1.00 438 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(3), THTPA(1) 2569519 7 4 7 1 2 1 2 1 1 0 0.83 1.00 439 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DAXX(4), DDIT3(1), ELK1(1), HMGN1(1), MAP3K1(5), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(4), RIPK1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2) 14709253 37 23 37 8 10 6 5 10 5 1 0.84 1.00 440 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 127 ACACA(8), ACACB(9), AKT1(1), AKT2(1), AKT3(1), ARAF(1), CALM1(1), CBL(1), CBLB(1), CBLC(1), ELK1(1), EXOC7(2), FASN(7), FBP1(2), FBP2(4), FLOT1(2), FOXO1(1), G6PC(2), GCK(2), GSK3B(1), GYS2(3), IKBKB(2), INPP5D(6), INSR(5), IRS1(4), IRS4(3), KRAS(1), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MAPK9(2), MKNK1(1), NRAS(1), PCK1(4), PCK2(1), PDE3A(1), PDE3B(4), PFKM(3), PFKP(6), PHKA1(3), PHKA2(4), PHKB(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PKLR(4), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3A(9), PPP1R3C(1), PPP1R3D(2), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(4), PYGB(4), PYGL(1), PYGM(2), RHOQ(3), RPS6KB1(1), SH2B2(3), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS4(2), SORBS1(2), SOS1(1), SOS2(4), SREBF1(2), TRIP10(4), TSC1(4), TSC2(2) 60122518 222 87 221 71 85 30 42 37 28 0 0.84 1.00 441 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(1), AKT2(1), AKT3(1), ASAH1(1), DAG1(2), DRD2(1), EPHB2(6), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), PIK3CB(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), SOS1(1), SOS2(4), SRC(2), STAT3(2), TERF2IP(3) 21593417 82 35 81 19 27 20 16 9 9 1 0.84 1.00 442 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 GNAQ(1), GNB1(1), GNGT1(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(1), PXN(1) 8497039 20 14 20 9 4 2 5 7 2 0 0.84 1.00 443 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(8), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), GNAS(3), MAPK1(3), MAPK14(1), MAPK3(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SOS1(1) 9904478 31 19 31 12 11 4 5 10 1 0 0.84 1.00 444 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(1), GNB1(1), GNGT1(1), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), PLA2G4A(4), PLCB1(3), PRKCA(3), PTGS1(2), PTK2(2), SRC(2), SYK(2), TBXAS1(3) 9811189 32 16 32 8 11 5 5 7 2 2 0.84 1.00 445 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(3), ABAT(2), ACY3(1), ADSSL1(1), AGXT2(2), ASNS(1), CAD(6), DLAT(1), DLD(1), GAD1(4), GAD2(3), GOT1(1), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1) 15040466 39 25 39 20 12 8 8 6 5 0 0.84 1.00 446 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), MAP2K3(1), MAPK14(1), NFATC1(3), NFATC2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 4513284 12 8 12 9 2 0 1 5 4 0 0.84 1.00 447 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TRAF2(2) 9608353 26 17 25 16 6 3 5 7 5 0 0.85 1.00 448 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP12A(5), ATP4A(5), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA3(1), NDUFA4(2), NDUFA4L2(1), NDUFA8(1), NDUFB1(1), NDUFB7(1), NDUFS2(1), NDUFS4(1), NDUFS7(1), NDUFV1(2), NDUFV2(2), PPA1(1), PPA2(1), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRQ(2) 22312708 77 37 77 25 23 16 20 10 8 0 0.85 1.00 449 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(7), CCNA1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F2(3), E2F3(2), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MYT1(7), NACA(7), PCNA(1), POLA2(3), POLE(4), POLE2(2), PRIM1(1), RBL1(3), TFDP2(1), TNXB(6) 28571523 82 38 79 28 26 13 19 9 15 0 0.85 1.00 450 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(8), GLI3(3), GSK3B(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(2), SUFU(2) 6443477 25 12 24 16 6 8 4 5 2 0 0.85 1.00 451 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(4), EIF4B(3), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), FKBP1A(1), MKNK1(1), PPP2CA(1), RPS6KB1(1), TSC1(4), TSC2(2) 9098958 25 14 25 4 5 3 5 3 9 0 0.85 1.00 452 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNB1(1), CHRNG(1), MUSK(1), PTK2(2), PTK2B(1), SRC(2), TERT(8) 4859970 17 9 17 4 9 3 2 1 2 0 0.85 1.00 453 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(1), ATM(7), ATR(9), BAI1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(3), DDB2(1), GADD45B(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(2), PERP(3), PPM1D(1), RFWD2(2), RPRM(1), SERPINB5(2), SERPINE1(1), SESN1(2), SESN2(1), SESN3(3), STEAP3(2), THBS1(3), TP53I3(2), TP73(1), TSC2(2) 24296544 62 36 62 27 13 17 12 9 10 1 0.85 1.00 454 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1), OXCT1(1) 1377947 2 2 2 0 0 0 1 1 0 0 0.85 1.00 455 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(5), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), PGM3(2), UAP1(1) 6734770 23 12 22 3 10 2 4 4 3 0 0.85 1.00 456 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2) 11521437 30 19 30 10 10 7 4 5 4 0 0.85 1.00 457 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(3), OAT(1), PRODH(1) 2059879 6 3 6 1 2 0 1 1 2 0 0.86 1.00 458 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), CASP1(4), GAPDH(1), INSR(5), ITCH(1), MAGI1(2), MAGI2(4), RERE(5), WWP2(2) 9532109 26 17 26 13 9 6 2 6 3 0 0.86 1.00 459 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(7), AXIN1(2), BTRC(1), CREBBP(8), CSNK2A1(3), CTBP1(3), FZD1(1), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(6), WIF1(2) 11291036 38 19 38 10 11 4 8 9 6 0 0.86 1.00 460 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(1) 530101 1 1 1 1 0 1 0 0 0 0 0.86 1.00 461 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTAP(1), MTFMT(1), MTR(2), TAT(3) 8300658 28 16 28 9 11 9 2 3 3 0 0.86 1.00 462 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(1), LDHA(2), LDHC(1), MPST(1) 2737319 6 4 6 1 1 1 2 1 1 0 0.87 1.00 463 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CCNE1(1), CUL1(5) 2747020 7 5 7 4 3 1 2 0 1 0 0.87 1.00 464 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), ATM(7), BCL2(3), CCNE1(1), CDKN1A(1), MDM2(1), PCNA(1), TIMP3(2) 6307728 17 10 17 2 3 5 4 3 2 0 0.87 1.00 465 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), SNCAIP(2), UBE2E2(2), UBE2L3(1) 2567484 8 4 8 2 2 0 2 2 2 0 0.87 1.00 466 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), GZMB(3), MAP3K1(5), MAP3K14(2), MDM2(1), NFKB1(1), NFKBIA(2), PARP1(3), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(5), TRAF1(1), TRAF2(2) 14497999 41 26 41 17 8 5 13 8 7 0 0.87 1.00 467 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(1), AKT3(1), ARHGEF11(3), BCL2(3), DLG4(2), LPA(6), MAP3K1(5), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PHKA2(4), PIK3CB(2), PLD2(1), PTK2(2), ROCK1(3), ROCK2(4), SRF(2) 19326712 54 30 54 20 16 11 10 7 10 0 0.88 1.00 468 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(5), NCOA1(3), NCOA2(1), RXRA(3) 7314514 20 10 20 5 3 4 7 2 3 1 0.88 1.00 469 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(2), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), NOX1(2), PLCB1(3), PPP1R12B(6), PRKCA(3), PTK2(2), ROCK2(4) 9085995 37 14 37 9 9 7 11 7 2 1 0.88 1.00 470 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2D(1), CAMK2G(4), DAG1(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFAT5(3), PDE6A(4), PDE6B(7), PDE6C(1), PDE6D(1), SLC6A13(2) 14093721 57 25 56 15 20 9 11 9 8 0 0.88 1.00 471 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(3), AGTR2(1), EDNRA(1), EDNRB(1), EGF(3), FOS(1), NFKB1(1), PLCG1(3), PRKCA(3) 7219548 18 12 18 13 3 3 3 7 2 0 0.88 1.00 472 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST12(1), CHST13(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4) 3705994 11 6 11 5 4 1 2 3 1 0 0.88 1.00 473 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 23 AKT1(1), APC(7), AXIN1(2), CD14(2), FZD1(1), GJA1(1), GSK3B(1), IRAK1(2), LBP(2), LEF1(1), LY96(1), NFKB1(1), PPP2CA(1), TLR4(1) 10180160 24 17 24 11 7 4 5 4 4 0 0.88 1.00 474 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(1), BIRC3(1), MAP3K3(4), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), RALBP1(3), RIPK1(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 10653196 33 17 33 16 10 5 5 8 5 0 0.88 1.00 475 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), FTCD(3), GART(3), MTFMT(1), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1) 7607519 21 12 21 9 5 4 5 3 4 0 0.88 1.00 476 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), GCK(2), GMDS(1), GMPPA(1), HK2(3), HK3(4), MPI(1), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1) 9558665 39 18 38 5 17 5 7 9 1 0 0.88 1.00 477 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA1(1), ACADM(2), ACADS(4), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 17450125 52 27 50 14 20 7 10 7 8 0 0.89 1.00 478 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), CHUK(4), DAXX(4), ELK1(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(1), NFKBIA(2), PAK1(2), RIPK1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SP1(6), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2) 37099530 107 51 105 38 32 12 15 27 21 0 0.89 1.00 479 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(8), CDR1(2), DGKI(3), FAU(1), PIGK(3), RPL10(1), RPL11(1), RPL14(1), RPL15(1), RPL18A(2), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL39(1), RPL5(2), RPL8(1), RPLP0(2), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), RPSA(1), TSPAN9(1), UBA52(1), UBB(1), UBC(1) 20666770 59 33 58 25 20 10 13 5 11 0 0.89 1.00 480 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(4), BAG4(1), CASP2(1), CRADD(1), DFFA(1), DFFB(3), LMNB1(1), LMNB2(3), MADD(6), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TRAF2(2) 14743687 46 25 46 12 9 10 10 11 6 0 0.89 1.00 481 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(4), ABO(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(4), B4GALT2(1), B4GALT4(1), B4GALT6(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2), ST3GAL1(2), ST3GAL3(1), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1) 18987660 70 32 70 19 22 8 21 14 5 0 0.89 1.00 482 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(7), ASAH1(1), CAV3(1), DAG1(2), DLG4(2), EPHB2(6), GNAQ(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), RHO(1), RYR1(14) 18204668 74 32 74 23 30 13 13 13 5 0 0.89 1.00 483 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(1), EPO(1), EPOR(1), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PLCG1(3), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2) 8596885 26 15 25 7 13 2 6 3 2 0 0.89 1.00 484 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC3(1), PSMD14(1), RPN1(1), UBE2A(1), UBE3A(4) 5186159 14 6 14 3 1 2 3 5 2 1 0.90 1.00 485 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25B(1), CDKN1A(1), NEK1(2) 2383928 4 3 4 1 0 1 2 1 0 0 0.90 1.00 486 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF2S2(1), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1R(2), INPPL1(4), PPP2CA(1), RPS6KB1(1) 6051096 16 9 16 3 3 3 2 4 4 0 0.90 1.00 487 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(1), UQCRC1(3) 2672895 4 4 4 4 0 2 0 1 1 0 0.90 1.00 488 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(7), ATR(9), BRCA1(4), CDC25B(1), CDKN1A(1), CDKN2D(1), EP300(5), MDM2(1), MYT1(7), PRKDC(5) 16182349 41 22 41 9 10 8 10 6 6 1 0.90 1.00 489 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(2), GTF2B(2), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(1), NCOA3(4), NCOR2(5), POLR2A(2), RXRA(3), TBP(2) 9328188 27 14 27 7 7 2 9 2 7 0 0.90 1.00 490 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(1), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), F2(1), GNA11(2), GNB1(1), GNGT1(1), JAK2(4), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK14(1), MAPK3(2), MAPT(1), MYLK(7), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), SYT1(1) 16725683 50 29 49 20 15 6 11 14 4 0 0.90 1.00 491 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(1), FUT5(2), FUT6(2), ST3GAL3(1) 1913974 8 3 8 5 5 1 1 1 0 0 0.90 1.00 492 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(3), GSK3B(1) 4666550 8 5 8 2 1 1 1 2 3 0 0.91 1.00 493 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT2(1), FUT8(1), ST3GAL1(2), ST3GAL3(1) 3137179 7 5 7 1 2 2 2 0 1 0 0.91 1.00 494 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), GH1(1), GHR(3), IGF1R(2), SOD3(1) 3770785 8 7 8 4 3 3 1 1 0 0 0.91 1.00 495 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), PAK1(2) 3001382 7 4 7 1 1 1 1 1 3 0 0.91 1.00 496 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF1D(4), EEF2(4), EEF2K(2), EIF2AK1(2), EIF2AK2(1), EIF2AK3(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G3(1), EIF5A(1), EIF5B(3), ETF1(1), GSPT2(1), KIAA0664(4), PABPC3(2) 17275881 45 23 43 13 10 5 7 17 6 0 0.91 1.00 497 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(8), MPI(1), PYGL(1), PYGM(2), TREH(2) 5368237 14 8 14 9 8 1 2 2 1 0 0.91 1.00 498 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 162 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY7(3), ADCY8(4), ADCY9(5), ADORA2B(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(4), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), ATP2B4(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CCKAR(3), CCKBR(2), CD38(2), CHRM2(4), CHRM3(3), CHRNA7(2), CYSLTR1(1), CYSLTR2(1), DRD1(2), EDNRA(1), EDNRB(1), ERBB2(7), ERBB3(4), ERBB4(1), GNA11(2), GNA15(4), GNAL(1), GNAQ(1), GNAS(3), GRIN1(3), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HRH1(1), HRH2(5), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), LHCGR(1), LTB4R2(2), MYLK(7), MYLK2(1), NOS1(9), NOS3(5), NTSR1(2), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), PDE1A(1), PDE1C(4), PDGFRB(5), PHKA1(3), PHKA2(4), PHKB(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PPID(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(14), RYR3(17), SLC25A5(2), SLC8A1(2), SLC8A3(2), SPHK1(1), TACR1(1), TACR3(4), TNNC1(1), TRHR(2), TRPC1(1), VDAC1(1), VDAC2(1) 99425284 435 140 428 141 193 52 77 64 48 1 0.92 1.00 499 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(4), CASP6(1), DAXX(4), DFFA(1), DFFB(3), FAF1(3), LMNB1(1), LMNB2(3), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), PTPN13(4), RIPK2(1), SPTAN1(6) 15563846 45 24 45 11 5 10 10 13 7 0 0.92 1.00 500 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX15(2), ALOX15B(1), ALOX5(1), DPEP1(3), GGT1(2), LTA4H(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3) 5728358 19 10 19 7 8 4 1 2 4 0 0.92 1.00 501 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 APAF1(1), ARHGDIB(4), BAG4(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), CHUK(4), CRADD(1), DAXX(4), DFFA(1), DFFB(3), GSN(2), LMNB1(1), LMNB2(3), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(1), NFKBIA(2), NUMA1(4), PRKCD(5), PRKDC(5), PSEN2(1), PTK2(2), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2) 26678168 76 38 75 25 15 11 22 16 12 0 0.92 1.00 502 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2) 1481400 2 2 2 4 2 0 0 0 0 0 0.92 1.00 503 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(7), AXIN1(2), BTRC(1), FZD1(1), GSK3B(1), NOTCH1(4) 7699463 16 11 14 8 3 0 4 8 1 0 0.92 1.00 504 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 3 PLCD1(1), PRKCA(3) 1488258 4 2 4 2 1 0 2 1 0 0 0.92 1.00 505 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(1), RANGAP1(1) 3294692 3 3 3 2 1 0 1 1 0 0 0.92 1.00 506 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(3) 3347164 10 4 10 5 2 1 2 3 1 1 0.92 1.00 507 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 64 ACAA1(1), ACADM(2), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), APOA2(1), APOA5(1), AQP7(2), CD36(2), CPT1A(1), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A11(3), CYP4A22(4), CYP8B1(2), EHHADH(2), FADS2(1), GK(1), GK2(2), HMGCS2(3), ILK(2), ME1(4), NR1H3(1), OLR1(3), PCK1(4), PCK2(1), PLTP(1), PPARA(1), RXRA(3), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A4(2), SLC27A6(4), SORBS1(2), UBC(1), UCP1(1) 25503182 83 39 81 30 23 11 14 18 17 0 0.93 1.00 508 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25B(1), PRKCA(3), PTPRA(4), SRC(2) 3687886 10 5 10 2 4 1 2 1 2 0 0.93 1.00 509 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 56 AANAT(1), ABP1(9), ACMSD(1), AFMID(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), CYP1A1(1), CYP1B1(4), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), HSD17B10(1), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), MAOB(1), NFX1(3), OGDH(1), OGDHL(5), PRMT7(2), PRMT8(1), TDO2(2), TPH1(3) 23868039 70 37 68 25 33 8 12 12 5 0 0.93 1.00 510 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(1), ACTB(1), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 20095421 63 33 63 27 21 9 14 14 5 0 0.93 1.00 511 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(1), ACTB(1), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 20095421 63 33 63 27 21 9 14 14 5 0 0.93 1.00 512 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(2) 2548853 6 3 6 1 0 2 1 3 0 0 0.93 1.00 513 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), PER1(3) 3359241 10 5 10 4 2 1 3 1 3 0 0.93 1.00 514 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(3) 6221687 16 8 16 9 3 3 3 4 2 1 0.93 1.00 515 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCL2(3), BCR(1), FOS(1), JAK2(4), MAP2K1(1), MAP3K1(5), MAPK3(2), SOS1(1), STAT1(1), STAT5A(2), STAT5B(2) 9624492 24 15 23 6 8 5 5 3 3 0 0.93 1.00 516 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(2), DOLPP1(1), DPAGT1(1), FUT8(1), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), RFT1(1), RPN1(1), ST6GAL1(4) 16795454 44 24 44 15 13 7 8 10 6 0 0.94 1.00 517 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(4), GLB1(1), HEXA(1), LCT(8), ST3GAL1(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1) 6634452 23 11 23 9 13 1 4 3 2 0 0.94 1.00 518 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), BTRC(1), CDC20(2), CDC23(1), CDC27(3), CUL1(5), CUL2(4), CUL3(1), FBXW11(2), FBXW7(2), ITCH(1), SMURF1(6), TCEB2(1), UBE2E2(2), VHL(1), WWP2(2) 16014634 46 23 46 10 11 4 9 12 10 0 0.94 1.00 519 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(1), ATM(7), ATR(9), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), DHFR(1), GSK3B(1), HDAC1(1), TGFB1(1), TGFB2(1) 11044664 32 16 32 9 6 8 6 4 8 0 0.94 1.00 520 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), RDH13(1) 1922363 5 3 5 0 4 0 1 0 0 0 0.94 1.00 521 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(2), OPRK1(1), POLR2A(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5009356 9 7 9 3 4 1 1 2 1 0 0.94 1.00 522 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(1), B4GALT7(1), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST3(1), CHST7(2), CHSY1(1), UST(2), XYLT1(3), XYLT2(1) 5485838 17 10 17 6 7 1 5 1 3 0 0.94 1.00 523 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), BIRC5(1), BNIP3L(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GZMB(3), IKBKB(2), IRF2(1), IRF4(2), IRF6(6), MAP3K1(5), MDM2(1), NFKB1(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PLEKHG5(2), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFSF10(5), TP73(1), TRAF1(1), TRAF2(2), TRAF3(3) 21748899 71 32 70 32 15 11 18 17 10 0 0.94 1.00 524 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AICDA(3), CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ENTPD3(1), ITPA(1), NME7(3), NT5C1B(3), NT5C2(2), NUDT2(1), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), TXNRD2(3), UPB1(1), UPP1(2), UPP2(1), ZNRD1(1) 32129500 89 44 89 36 28 12 26 11 12 0 0.94 1.00 525 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT2(1), B3GALT5(2), B3GNT5(1), FUT1(1), ST3GAL3(1) 2868757 8 4 8 6 4 1 2 1 0 0 0.94 1.00 526 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(2), DHRS7(1), PON1(4), PON3(2), RDH13(1) 3385089 10 5 10 3 4 1 3 2 0 0 0.95 1.00 527 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(3) 2874536 8 3 8 7 2 1 1 3 0 1 0.95 1.00 528 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), GNB1(1), GNGT1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3) 3641689 11 5 11 8 4 0 3 4 0 0 0.95 1.00 529 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(4), BTK(1), EEA1(2), GRASP(2), GSK3B(1), LYN(1), PFKM(3), PFKP(6), PLCG1(3), PRKCE(1), PRKCZ(2), RPS6KB1(1), VAV2(3) 9711807 33 15 33 11 9 8 4 5 7 0 0.95 1.00 530 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GGT1(2), SHMT2(1) 2166090 4 3 4 1 2 0 1 0 1 0 0.95 1.00 531 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(2), ACO2(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), PC(3), PCK1(4), SUCLA2(1), SUCLG1(2) 7900909 21 12 21 14 3 5 9 4 0 0 0.95 1.00 532 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(2), ACO2(1), IDH2(2), MDH2(1), SUCLA2(1) 3264809 7 5 7 7 2 1 4 0 0 0 0.95 1.00 533 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(3), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2) 9471806 29 14 29 4 8 4 10 4 2 1 0.95 1.00 534 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(1), ALDOC(3) 1572725 7 2 7 1 3 2 1 1 0 0 0.95 1.00 535 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(1), FOS(1), IL2(1), IL2RA(3), IL2RB(1), JAK1(3), JAK3(4), MAP2K1(1), MAPK3(2), SOS1(1), STAT5A(2), STAT5B(2), SYK(2) 9381702 27 14 26 12 9 2 7 6 3 0 0.95 1.00 536 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1B10(2), AKR1C4(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), RDH13(1), SOAT1(2), SOAT2(2) 12781541 37 20 37 9 17 7 8 5 0 0 0.95 1.00 537 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NFKBIL2(6), PHKA2(4), PIK3CB(2), PLD2(1), VN1R1(1) 17422545 60 26 60 15 18 11 9 10 12 0 0.95 1.00 538 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(3), ELK1(1), FOS(1), MAP2K1(1), MAPK3(2), NGFR(1), PLCG1(3), SOS1(1) 6141192 13 8 13 5 5 2 2 2 2 0 0.95 1.00 539 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(1), MAT1A(2), PAPSS2(1), SCLY(1), SEPHS1(1) 4922070 11 7 11 7 5 2 2 2 0 0 0.95 1.00 540 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB3(1), CREB5(1), DUSP4(3), DUSP9(1), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NFKB1(1), RPS6KA2(2), RPS6KA3(5), SOS1(1), SOS2(4), TRAF3(3) 11251091 34 17 33 9 11 3 7 11 2 0 0.95 1.00 541 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), ROCK1(3), SRC(2), TLN1(6) 13637503 36 20 36 9 14 4 7 5 6 0 0.95 1.00 542 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(1), AKT2(1), AKT3(1), CDKN1B(3), CDKN2A(3), CREB3(1), CREB5(1), ERBB4(1), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), MET(5), NOLC1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARD3(2), PARD6A(1), PIK3CD(2), PREX1(9), PTK2(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SLC2A4(3), SOS1(1), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAE(2) 28824124 82 38 82 26 25 9 13 16 19 0 0.95 1.00 543 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), AK1(1), ALLC(3), AMPD1(7), AMPD3(4), ATIC(1), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NPR2(1), NUDT2(1), PAPSS2(1), PDE1A(1), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6B(7), PDE6C(1), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(5), PKLR(4), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2) 50384760 143 66 138 54 58 14 31 18 21 1 0.95 1.00 544 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2) 1933650 6 2 6 4 4 0 1 0 1 0 0.96 1.00 545 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1) 6826923 11 8 11 7 2 2 2 3 2 0 0.96 1.00 546 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(1), ACTA2(2), ACTN3(1), ACTN4(4), DES(3), DMD(11), FAM48A(5), MYBPC1(2), MYBPC2(1), MYBPC3(3), MYH3(6), MYH6(5), MYH7(3), MYH8(8), MYL2(2), MYOM1(3), NEB(11), TNNI1(2), TNNT1(2), TNNT2(1), TPM1(1), TPM3(1), TPM4(1), VIM(1) 23852628 80 35 80 32 32 14 17 11 6 0 0.96 1.00 547 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 53 ASH1L(3), ASH2L(1), CARM1(1), CTCFL(3), EED(2), EHMT1(3), EHMT2(2), EZH1(2), EZH2(2), FBXO11(3), HCFC1(3), HSF4(1), JMJD4(2), KDM6A(2), MEN1(2), MLL(3), MLL2(7), MLL3(12), MLL4(7), MLL5(3), NSD1(7), OGT(3), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(9), SETD7(2), SETD8(1), SETDB2(3), SMYD3(1), SUV39H2(3), SUV420H1(1), SUV420H2(3), SUZ12(1), WHSC1(4), WHSC1L1(7) 45951361 121 53 120 38 25 20 31 21 24 0 0.96 1.00 548 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1) 6163897 14 8 14 7 3 2 2 4 3 0 0.96 1.00 549 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHFR(1), DHX58(2), EP400(15), ERCC2(1), ERCC3(2), FPGS(2), IFIH1(2), MOV10L1(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SKIV2L2(1), SMARCA2(5), SMARCA5(2) 24991247 79 37 79 26 25 13 18 14 9 0 0.96 1.00 550 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(1), ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ATM(7), ATR(9), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDC20(2), CDC23(1), CDC25B(1), CDC27(3), CDC7(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREBBP(8), CUL1(5), E2F2(3), E2F3(2), EP300(5), ESPL1(8), GADD45B(1), GSK3B(1), HDAC1(1), HDAC2(3), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(5), PTTG2(2), RBL1(3), RBL2(1), SMAD3(1), SMAD4(1), SMC1A(7), SMC1B(3), TGFB1(1), TGFB2(1), YWHAB(1), YWHAE(2) 52835399 142 60 141 40 28 29 39 17 28 1 0.96 1.00 551 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(1) 2926677 6 4 6 3 2 0 2 1 1 0 0.96 1.00 552 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(7), AXIN1(2), CREBBP(8), EP300(5), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), TRRAP(8) 12947179 35 20 35 17 10 4 13 4 3 1 0.96 1.00 553 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), FOS(1), HDAC2(3), HDAC5(4), NCOR2(5), RBL1(3), RBL2(1), SIN3A(2), SIN3B(6) 10170982 28 14 28 7 9 4 8 3 4 0 0.96 1.00 554 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMB8(1) 3478665 7 4 7 1 1 1 1 3 1 0 0.96 1.00 555 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1) 5295093 9 7 9 4 4 0 3 1 1 0 0.97 1.00 556 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(1), BCL2(3), CASP8AP2(3), CES1(2) 3968535 9 5 9 0 2 1 3 1 2 0 0.97 1.00 557 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(1), SOS1(1), SRC(2) 3530468 4 4 4 4 1 1 1 1 0 0 0.97 1.00 558 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), GART(3), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1) 7282297 17 10 17 9 4 4 5 1 3 0 0.97 1.00 559 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(4), AKT1(1), ATM(7), CDKN1A(1), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MDM2(1), NFKBIB(1) 7719882 19 10 19 4 6 7 1 3 2 0 0.97 1.00 560 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), NPAS2(1), NR1D1(3), PER1(3), PER2(2), PER3(1) 6718626 17 10 16 8 5 2 3 4 3 0 0.97 1.00 561 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(2), ACO1(2), ACO2(1), ACSS2(2), IDH2(2), MDH2(1), SUCLA2(1) 5050395 11 7 11 7 4 1 5 1 0 0 0.97 1.00 562 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2) 6448451 14 8 14 4 2 2 3 3 4 0 0.97 1.00 563 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(1), ATM(7), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(5), CDC20(2), CDC25B(1), CDC7(2), CDH1(3), CDKN1A(1), CDKN2A(3), E2F2(3), E2F3(2), EP300(5), ESPL1(8), GSK3B(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), HDAC8(1), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MPL(2), PCNA(1), PLK1(1), PRKDC(5), PTPRA(4), PTTG2(2), RBL1(3), SMAD4(1), TBC1D8(4), TGFB1(1) 42619691 109 50 108 39 26 22 30 12 18 1 0.97 1.00 564 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ITPA(1), NUDT2(1), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), RRM1(2), TK2(1), TXNRD1(1), UPB1(1), UPP1(2) 22781723 58 30 57 26 15 9 19 7 7 1 0.97 1.00 565 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(2), ACO1(2), ACO2(1), CLYBL(3), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), OGDHL(5), PC(3), PCK1(4), PCK2(1), SUCLA2(1), SUCLG1(2) 11623506 33 17 33 17 8 6 12 6 1 0 0.97 1.00 566 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ASH1L(3), CASK(2), CGN(3), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CRB3(1), CSDA(1), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41(2), EPB41L1(2), EPB41L2(2), EPB41L3(7), EXOC3(3), EXOC4(1), F11R(1), GNAI2(1), HCLS1(5), INADL(3), JAM2(1), JAM3(1), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(2), MLLT4(5), MPDZ(5), MPP5(1), MYH1(3), MYH10(3), MYH11(7), MYH13(11), MYH14(6), MYH15(3), MYH3(6), MYH4(6), MYH6(5), MYH7(3), MYH7B(9), MYH8(8), MYH9(8), MYL2(2), MYLPF(1), NRAS(1), OCLN(1), PARD3(2), PARD6A(1), PARD6B(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(3), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), RHOA(1), RRAS2(3), SPTAN1(6), SRC(2), SYMPK(4), TJAP1(5), TJP1(2), TJP2(3), TJP3(6), ZAK(1) 74347867 243 95 239 103 101 31 46 36 29 0 0.97 1.00 567 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 FOS(1), MAPK1(3), MAPK14(1), NFE2L2(1), PRKCA(3) 3445740 9 4 9 4 2 2 1 4 0 0 0.97 1.00 568 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(7), ATR(9), BRCA1(4), BRCA2(7), FANCA(4), FANCC(2), FANCD2(4), FANCG(1), MRE11A(3), RAD1(1), RAD17(2), RAD50(2), RAD9A(1) 17216522 47 20 47 8 11 8 6 13 8 1 0.97 1.00 569 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CYP2C9(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2) 12265492 30 18 30 10 7 5 6 6 6 0 0.97 1.00 570 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2), SHMT2(1) 1612285 3 2 3 0 2 0 1 0 0 0 0.97 1.00 571 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTR(2) 7027617 22 11 22 9 9 6 2 3 2 0 0.97 1.00 572 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), DFFA(1), DFFB(3), DIABLO(1) 5274802 12 8 12 2 3 0 5 3 1 0 0.98 1.00 573 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), ACVR1C(2), CDH1(3), CREBBP(8), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), EP300(5), ERBB2(7), FARP2(2), FGFR1(3), IGF1R(2), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(3), MAPK3(2), MET(5), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(4), PTPRF(4), PTPRJ(2), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(5), RHOA(1), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(2), SSX2IP(1), TCF7(3), TCF7L2(3), TGFBR1(1), TGFBR2(5), TJP1(2), VCL(2), WASF1(1), WASF2(1) 46520680 129 59 125 38 41 22 29 21 14 2 0.98 1.00 574 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(1), CDKN2A(3), MDM2(1), POLR1A(3), POLR1B(1), POLR1C(1), TBX2(1) 5445052 11 6 11 10 1 4 3 1 2 0 0.98 1.00 575 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), MAP2(3), PPP2CA(1), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1), PRKCE(1) 7405607 14 8 14 9 2 5 2 3 2 0 0.98 1.00 576 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2(3), BCL2A1(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CRADD(1), DAXX(4), DFFA(1), DFFB(3), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(4), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3) 17487405 45 25 45 16 10 7 12 11 5 0 0.98 1.00 577 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2) 2219692 2 2 2 1 1 0 1 0 0 0 0.98 1.00 578 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), FN3K(1), HADHA(1), ITGB1BP3(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2) 10227781 23 13 23 7 4 5 3 5 6 0 0.98 1.00 579 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), WASF1(1) 3282209 7 3 7 1 1 1 1 1 3 0 0.98 1.00 580 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B10(2), ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), FUK(1), GMDS(1), GMPPA(1), HK2(3), HK3(4), LHPP(1), MPI(1), MTMR1(2), MTMR2(3), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1), RDH13(1) 14193703 48 21 47 6 21 6 9 10 2 0 0.98 1.00 581 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(3), CARS2(3), EARS2(2), EPRS(2), FARSA(1), FARSB(1), HARS(3), HARS2(1), IARS(4), IARS2(1), KARS(4), LARS(3), LARS2(1), MARS(1), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(1), VARS(3), VARS2(5), YARS(2), YARS2(2) 21945440 59 29 58 22 16 9 13 13 8 0 0.98 1.00 582 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), GPI(4), PKLR(4) 3384490 9 4 9 2 5 0 1 1 2 0 0.98 1.00 583 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(3), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), MPL(2), PLCG1(3), PRKCA(3), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), THPO(1) 10511170 28 14 27 7 12 4 6 4 2 0 0.99 1.00 584 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 15 CARM1(1), LCMT1(1), PCYT1A(1), PCYT1B(2), PRMT7(2), PRMT8(1) 5326483 8 6 8 5 3 0 3 1 1 0 0.99 1.00 585 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(3), APC(7), ATF2(1), AXIN1(2), BMP10(2), BMP5(3), BMPR1A(2), BMPR2(2), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(2), MEF2C(1), MYL2(2), RFC1(3), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2) 14155219 44 18 44 13 9 6 13 10 6 0 0.99 1.00 586 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), ARPC4(1), DIAPH1(2), GSN(2), LIMK1(1), MYL2(2), MYLK(7), OPHN1(1), PIP5K1B(2), PPP1R12B(6), ROCK1(3), SRC(2), TLN1(6), VCL(2) 18138147 52 23 52 15 21 7 8 6 10 0 0.99 1.00 587 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 35 CCNH(2), ERCC3(2), GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(2), POLR1A(3), POLR1B(1), POLR2A(2), POLR2B(4), POLR3B(4), POLR3D(1), TAF5(2), TAF6(3), TAF7(2), TAF9(1), TBP(2) 14056316 36 17 35 6 7 5 13 5 6 0 0.99 1.00 588 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GAS2(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(2), TNFRSF25(1), TNFSF10(5), TRAF2(2) 13210098 38 18 37 13 8 1 14 11 4 0 0.99 1.00 589 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(1), CBX3(1), CLDN5(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), EIF4G2(2), GFRA1(1), GSTM3(1), GSTP1(1), HERPUD1(1), KLF9(1), NCKAP1(2), PER1(3), PER2(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(2), TUBB3(1), UCP3(2), UGP2(1), ZFR(1) 13941857 36 17 36 11 10 2 12 5 7 0 0.99 1.00 590 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB3(1), CREB5(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(1), IL1R1(2), MAP2K3(1), MAP3K10(3), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), NFKB1(1), SRF(2) 13300265 30 18 30 9 10 4 1 11 4 0 0.99 1.00 591 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLG(4), POLH(2), POLI(2), POLK(1), POLL(2), POLM(1), POLQ(7), PRIM1(1), REV1(1), REV3L(6), RFC5(1) 16146761 46 19 45 16 11 7 15 7 5 1 0.99 1.00 592 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25B(1), SHH(2), XPO1(2) 3517835 7 3 7 0 0 2 3 2 0 0 0.99 1.00 593 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), ZNRD1(1) 9520788 23 12 23 3 8 4 5 3 3 0 0.99 1.00 594 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(1), GNAS(3), GNB1(1), GNGT1(1), IGF1R(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NGFR(1), PPP2CA(1), PTPRR(2), SOS1(1), SRC(2), STAT3(2) 11268813 25 16 25 10 12 5 3 4 1 0 0.99 1.00 595 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1), PDK3(1), PDK4(2), PDP2(1), SUCLA2(1), SUCLG1(2) 11406070 26 14 26 17 7 6 7 4 2 0 0.99 1.00 596 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), NRG2(1), NRG3(1), PRKCA(3) 3608656 6 3 6 4 3 0 1 1 1 0 0.99 1.00 597 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN3(1), BCR(1), CAPN1(5), CAPNS1(1), CAV1(1), ITGA1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), PPP1R12B(6), PTK2(2), PXN(1), ROCK1(3), SOS1(1), SRC(2), TLN1(6), VCL(2), ZYX(2) 18381154 44 22 44 14 16 6 6 11 5 0 0.99 1.00 598 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC2(1), PSMC3(1), PSMD11(1), PSMD12(3) 6453136 12 5 12 3 1 1 2 4 4 0 0.99 1.00 599 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), AKAP10(4), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(2), AKAP5(2), AKAP6(5), AKAP7(1), AKAP8(3), AKAP9(4), ARHGEF1(2), CALM1(1), GNA11(2), GNA12(2), GNA15(4), GNAI2(1), GNAL(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNGT1(1), GNGT2(1), ITPR1(7), KCNJ3(2), KRAS(1), NRAS(1), PDE1A(1), PDE1C(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PLCB3(5), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), PRKD3(6), RHOA(1), SLC9A1(3), USP5(5) 46657373 152 58 151 47 51 24 33 24 20 0 0.99 1.00 600 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN3(1), CTNNA1(1), CTNNA2(2), PECAM1(2), PTK2(2), PXN(1), SRC(2), VCL(2) 7930015 14 9 14 6 5 2 3 2 2 0 1.00 1.00 601 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(2), GBF1(5), GPLD1(2), KDELR1(1), KDELR2(1) 6465040 15 6 15 6 5 2 3 4 0 1 1.00 1.00 602 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN3(1), CAPN1(5), CAPNS1(1), ITGA1(1), ITGB3(1), PTK2(2), PXN(1), SPTAN1(6), SRC(2), TLN1(6) 11191079 28 13 28 10 13 2 4 7 2 0 1.00 1.00 603 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 139 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADSSL1(1), AK1(1), AK7(2), ALLC(3), AMPD1(7), AMPD3(4), ATIC(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), ENTPD3(1), GART(3), GMPR(1), GMPR2(1), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NME7(3), NPR2(1), NT5C1B(3), NT5C2(2), NUDT2(1), PAPSS2(1), PDE11A(2), PDE1A(1), PDE1C(4), PDE2A(3), PDE3B(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6D(1), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(1), RRM1(2), XDH(8), ZNRD1(1) 64495867 190 77 187 68 70 28 42 21 29 0 1.00 1.00 604 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(1), APAF1(1), ATM(7), BCL2(3), CASP6(1), PRKCA(3), PTK2(2), PXN(1), STAT1(1), TLN1(6) 10587692 26 12 26 4 8 4 5 6 3 0 1.00 1.00 605 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 1626459 1 1 1 0 0 0 0 1 0 0 1.00 1.00 606 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), DRD1(2), DRD2(1), GRM1(1), PLCB1(3), PPP2CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 6247312 12 5 12 11 4 2 1 3 1 1 1.00 1.00 607 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(1), ATM(7), BRCA1(4), CDKN1A(1), MDM2(1), MRE11A(3), NFKB1(1), NFKBIA(2), RAD50(2), RBBP8(2), TP73(1) 11257255 25 11 25 8 5 8 3 6 3 0 1.00 1.00 608 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), IDH2(2), OGDH(1), SUCLA2(1) 3806392 5 3 5 9 2 1 2 0 0 0 1.00 1.00 609 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 183 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ARHGAP5(2), BCL2(3), BIRC2(1), BIRC3(1), CAPN2(1), CAV1(1), CAV3(1), CCND2(1), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DIAPH1(2), DOCK1(9), EGF(3), ELK1(1), ERBB2(7), FARP2(2), FIGF(1), FLNA(14), FLNB(4), FLNC(6), FLT1(2), FN1(3), GRLF1(4), GSK3B(1), HGF(4), IGF1R(2), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KDR(10), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), MAP2K1(1), MAPK1(3), MAPK3(2), MAPK9(2), MET(5), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARVB(1), PARVG(2), PDGFC(3), PDGFD(2), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), RAP1B(2), RELN(20), RHOA(1), ROCK1(3), ROCK2(4), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TLN1(6), TLN2(5), TNC(7), TNN(5), TNR(2), TNXB(6), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), VEGFA(2), VEGFC(2), VWF(10), ZYX(2) 136679796 514 162 508 178 182 88 93 74 76 1 1.00 1.00 610 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), EPRS(2), HARS(3), IARS(4), KARS(4), LARS(3), LARS2(1), MARS(1), NARS(1), QARS(3), TARS(2), YARS(2) 13075913 29 14 29 11 8 6 5 5 5 0 1.00 1.00 611 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1) 1723510 2 1 2 0 1 0 0 1 0 0 1.00 1.00 612 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), PLOD1(2), PLOD3(1), SDS(4), SHMT2(1), TMLHE(1) 14665322 40 17 40 9 7 12 9 6 6 0 1.00 1.00 613 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(2), LCMT1(1), MARS(1), MAT1A(2), PAPSS2(1), PRMT7(2), PRMT8(1), SCLY(1), SEPHS1(1) 9615700 16 10 16 12 8 2 3 3 0 0 1.00 1.00 614 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), DHRS7(1), LCMT1(1), PRMT7(2), PRMT8(1) 5440284 6 4 6 7 3 0 2 1 0 0 1.00 1.00 615 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CLK2(2), CLK4(2), COL2A1(2), CPSF1(4), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDIT3(1), DHX15(1), DHX16(4), DHX38(4), DHX8(4), DHX9(2), DICER1(4), FUS(1), GIPC1(2), NCBP2(1), NONO(3), NUDT21(2), NXF1(1), PABPN1(2), PHF5A(1), POLR2A(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(9), PSKH1(1), PTBP1(2), PTBP2(1), RBM17(1), RNGTT(1), SF3A1(2), SF3A3(2), SF3B1(2), SF3B2(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SRPK1(2), SRPK2(3), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF2(2), XRN2(2) 41964994 94 40 94 19 28 9 22 14 21 0 1.00 1.00 616 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), HSD17B10(1), HSD17B4(1), NSD1(7), OGDH(1), OGDHL(5), PIPOX(2), PLOD1(2), PLOD3(1), RDH13(1), SETD1A(1), SETD7(2), SHMT2(1), SUV39H2(3), TMLHE(1) 23173273 53 23 53 14 17 8 14 8 6 0 1.00 1.00