Glioblastoma Multiforme: PARADIGM pathway analysis of mRNA expression and copy number data
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 98 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
HIF-1-alpha transcription factor network 131
FOXM1 transcription factor network 107
Syndecan-4-mediated signaling events 88
Angiopoietin receptor Tie2-mediated signaling 88
Endothelins 82
TCGA08_rtk_signaling 75
Thromboxane A2 receptor signaling 74
HIF-2-alpha transcription factor network 74
TCGA08_p53 73
EGFR-dependent Endothelin signaling events 71
Results

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
HIF-1-alpha transcription factor network 131 9979 76 -0.078 0.1 1000 -1000 -0.01 -1000
FOXM1 transcription factor network 107 5487 51 -0.32 0.061 1000 -1000 -0.056 -1000
Syndecan-4-mediated signaling events 88 5938 67 -0.14 0.036 1000 -1000 -0.031 -1000
Angiopoietin receptor Tie2-mediated signaling 88 7788 88 -0.29 0.053 1000 -1000 -0.048 -1000
Endothelins 82 7877 96 -0.14 0.036 1000 -1000 -0.03 -1000
TCGA08_rtk_signaling 75 1965 26 -0.024 0.093 1000 -1000 -0.006 -1000
Thromboxane A2 receptor signaling 74 7826 105 -0.069 0.044 1000 -1000 -0.023 -1000
HIF-2-alpha transcription factor network 74 3189 43 -0.074 0.047 1000 -1000 -0.053 -1000
TCGA08_p53 73 512 7 -0.001 0.034 1000 -1000 -0.011 -1000
EGFR-dependent Endothelin signaling events 71 1492 21 -0.005 0.093 1000 -1000 -0.009 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 71 2369 33 -0.075 0.068 1000 -1000 -0.01 -1000
Effects of Botulinum toxin 68 1774 26 -0.007 0.052 1000 -1000 -0.011 -1000
PDGFR-alpha signaling pathway 66 2929 44 -0.093 0.036 1000 -1000 -0.023 -1000
Syndecan-3-mediated signaling events 65 2295 35 -0.071 0.08 1000 -1000 -0.021 -1000
Wnt signaling 65 461 7 -0.006 0.037 1000 -1000 0 -1000
Arf6 signaling events 64 3986 62 -0.005 0.092 1000 -1000 -0.003 -1000
Canonical Wnt signaling pathway 64 3284 51 -0.097 0.071 1000 -1000 -0.027 -1000
S1P5 pathway 62 1069 17 -0.007 0.036 1000 -1000 -0.011 -1000
S1P4 pathway 62 1560 25 -0.012 0.043 1000 -1000 -0.008 -1000
TCGA08_retinoblastoma 61 493 8 -0.045 0.053 1000 -1000 -0.001 -1000
Ras signaling in the CD4+ TCR pathway 61 1045 17 -0.001 0.042 1000 -1000 -0.007 -1000
LPA receptor mediated events 60 6127 102 -0.13 0.039 1000 -1000 -0.037 -1000
EPO signaling pathway 57 3152 55 -0.001 0.082 1000 -1000 -0.012 -1000
Syndecan-1-mediated signaling events 55 1894 34 -0.004 0.035 1000 -1000 -0.017 -1000
Nongenotropic Androgen signaling 55 2897 52 -0.087 0.06 1000 -1000 -0.024 -1000
Syndecan-2-mediated signaling events 54 3737 69 -0.026 0.037 1000 -1000 -0.022 -1000
IL2 signaling events mediated by STAT5 52 1152 22 -0.074 0.042 1000 -1000 -0.021 -1000
Fc-epsilon receptor I signaling in mast cells 51 5040 97 -0.12 0.048 1000 -1000 -0.042 -1000
amb2 Integrin signaling 51 4239 82 -0.015 0.077 1000 -1000 -0.02 -1000
Glypican 2 network 51 206 4 0 0.007 1000 -1000 0 -1000
IL23-mediated signaling events 51 3086 60 -0.064 0.15 1000 -1000 -0.026 -1000
JNK signaling in the CD4+ TCR pathway 50 855 17 -0.14 0.063 1000 -1000 -0.017 -1000
Osteopontin-mediated events 49 1862 38 -0.071 0.05 1000 -1000 -0.015 -1000
PLK2 and PLK4 events 48 146 3 -0.011 0.035 1000 -1000 -0.015 -1000
Ephrin B reverse signaling 46 2219 48 -0.067 0.066 1000 -1000 -0.048 -1000
Signaling events mediated by VEGFR1 and VEGFR2 45 5642 125 -0.045 0.06 1000 -1000 -0.037 -1000
Presenilin action in Notch and Wnt signaling 44 2721 61 -0.079 0.08 1000 -1000 -0.041 -1000
FoxO family signaling 44 2842 64 -0.16 0.052 1000 -1000 -0.034 -1000
FAS signaling pathway (CD95) 44 2076 47 -0.16 0.048 1000 -1000 -0.028 -1000
IL2 signaling events mediated by PI3K 44 2559 58 -0.065 0.038 1000 -1000 -0.019 -1000
BCR signaling pathway 44 4383 99 -0.061 0.05 1000 -1000 -0.034 -1000
EPHB forward signaling 43 3716 85 -0.052 0.082 1000 -1000 -0.042 -1000
Regulation of nuclear SMAD2/3 signaling 42 5791 136 -0.21 0.19 1000 -1000 -0.044 -1000
Sphingosine 1-phosphate (S1P) pathway 42 1187 28 -0.012 0.036 1000 -1000 -0.014 -1000
Noncanonical Wnt signaling pathway 42 1107 26 -0.039 0.037 1000 -1000 -0.022 -1000
Arf6 downstream pathway 42 1812 43 -0.026 0.051 1000 -1000 -0.031 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 42 2858 68 -0.1 0.046 1000 -1000 -0.032 -1000
E-cadherin signaling in keratinocytes 42 1836 43 -0.042 0.064 1000 -1000 -0.014 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 41 2226 54 -0.034 0.082 1000 -1000 -0.027 -1000
Reelin signaling pathway 41 2333 56 -0.014 0.068 1000 -1000 -0.015 -1000
Paxillin-dependent events mediated by a4b1 41 1485 36 -0.057 0.059 1000 -1000 -0.046 -1000
BMP receptor signaling 40 3297 81 -0.031 0.058 1000 -1000 -0.009 -1000
Class I PI3K signaling events 40 2991 73 -0.053 0.062 1000 -1000 -0.016 -1000
IL12-mediated signaling events 39 3403 87 -0.11 0.094 1000 -1000 -0.025 -1000
Paxillin-independent events mediated by a4b1 and a4b7 39 1469 37 -0.034 0.083 1000 -1000 -0.017 -1000
IL1-mediated signaling events 39 2433 62 -0.045 0.074 1000 -1000 -0.036 -1000
IL6-mediated signaling events 39 2955 75 -0.076 0.11 1000 -1000 -0.027 -1000
S1P3 pathway 39 1645 42 -0.018 0.036 1000 -1000 -0.015 -1000
Signaling events mediated by PTP1B 38 2927 76 -0.033 0.059 1000 -1000 -0.033 -1000
Glypican 1 network 38 1850 48 -0.038 0.051 1000 -1000 -0.033 -1000
p38 MAPK signaling pathway 38 1673 44 0 0.043 1000 -1000 -0.012 -1000
ErbB2/ErbB3 signaling events 37 2430 65 -0.044 0.036 1000 -1000 -0.057 -1000
PLK1 signaling events 37 3222 85 -0.048 0.051 1000 -1000 -0.021 -1000
mTOR signaling pathway 37 2005 53 -0.034 0.046 1000 -1000 -0.028 -1000
Stabilization and expansion of the E-cadherin adherens junction 37 2768 74 -0.12 0.079 1000 -1000 -0.052 -1000
Hedgehog signaling events mediated by Gli proteins 36 2404 65 -0.015 0.057 1000 -1000 -0.017 -1000
TCR signaling in naïve CD8+ T cells 36 3349 93 -0.35 0.4 1000 -1000 -0.026 -1000
Neurotrophic factor-mediated Trk receptor signaling 36 4374 120 -0.035 0.087 1000 -1000 -0.037 -1000
Class I PI3K signaling events mediated by Akt 35 2410 68 -0.03 0.063 1000 -1000 -0.019 -1000
Regulation of p38-alpha and p38-beta 35 1932 54 -0.002 0.047 1000 -1000 -0.015 -1000
IGF1 pathway 35 2039 57 -0.046 0.066 1000 -1000 -0.03 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 34 2895 85 -0.12 0.12 1000 -1000 -0.031 -1000
Alternative NF-kappaB pathway 34 451 13 0 0.066 1000 -1000 0 -1000
IFN-gamma pathway 33 2249 68 -0.041 0.064 1000 -1000 -0.036 -1000
PDGFR-beta signaling pathway 33 3246 97 -0.055 0.068 1000 -1000 -0.041 -1000
a4b1 and a4b7 Integrin signaling 32 162 5 0.027 0.052 1000 -1000 0.033 -1000
S1P1 pathway 32 1156 36 -0.005 0.052 1000 -1000 -0.017 -1000
Plasma membrane estrogen receptor signaling 32 2816 86 -0.066 0.053 1000 -1000 -0.034 -1000
Caspase cascade in apoptosis 31 2309 74 -0.079 0.067 1000 -1000 -0.031 -1000
ErbB4 signaling events 31 2153 69 -0.071 0.062 1000 -1000 -0.019 -1000
IL4-mediated signaling events 31 2877 91 -0.32 0.067 1000 -1000 -0.068 -1000
E-cadherin signaling in the nascent adherens junction 31 2420 76 -0.043 0.09 1000 -1000 -0.035 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 31 2481 78 -0.022 0.072 1000 -1000 -0.03 -1000
Aurora A signaling 30 1812 60 -0.028 0.058 1000 -1000 -0.015 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 30 1359 45 -0.032 0.075 1000 -1000 -0.027 -1000
p75(NTR)-mediated signaling 29 3698 125 -0.022 0.087 1000 -1000 -0.041 -1000
Signaling events mediated by HDAC Class III 29 1172 40 -0.049 0.05 1000 -1000 -0.049 -1000
Signaling events regulated by Ret tyrosine kinase 29 2453 82 -0.057 0.063 1000 -1000 -0.026 -1000
Integrins in angiogenesis 29 2498 84 -0.044 0.071 1000 -1000 -0.016 -1000
Insulin Pathway 29 2217 74 -0.036 0.082 1000 -1000 -0.031 -1000
Signaling events mediated by PRL 29 1007 34 -0.034 0.047 1000 -1000 -0.023 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 28 646 23 -0.016 0.054 1000 -1000 -0.003 -1000
Visual signal transduction: Cones 28 1089 38 -0.014 0.058 1000 -1000 -0.012 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 28 2369 83 -0.034 0.068 1000 -1000 -0.013 -1000
Aurora B signaling 28 1889 67 -0.032 0.062 1000 -1000 -0.015 -1000
TRAIL signaling pathway 27 1332 48 -0.033 0.086 1000 -1000 -0.016 -1000
Signaling mediated by p38-gamma and p38-delta 27 417 15 -0.025 0.036 1000 -1000 -0.015 -1000
Retinoic acid receptors-mediated signaling 27 1590 58 -0.053 0.059 1000 -1000 -0.018 -1000
BARD1 signaling events 26 1503 57 -0.064 0.085 1000 -1000 -0.061 -1000
Glucocorticoid receptor regulatory network 25 2956 114 -0.13 0.064 1000 -1000 -0.042 -1000
Regulation of Telomerase 25 2612 102 -0.027 0.077 1000 -1000 -0.036 -1000
Circadian rhythm pathway 24 536 22 -0.01 0.056 1000 -1000 -0.018 -1000
Nectin adhesion pathway 24 1512 63 -0.01 0.084 1000 -1000 -0.032 -1000
Signaling events mediated by HDAC Class I 24 2514 104 -0.029 0.066 1000 -1000 -0.024 -1000
Arf6 trafficking events 24 1737 71 -0.038 0.046 1000 -1000 -0.035 -1000
Insulin-mediated glucose transport 22 710 32 -0.016 0.041 1000 -1000 -0.014 -1000
Ceramide signaling pathway 22 1722 76 -0.04 0.07 1000 -1000 -0.016 -1000
Calcium signaling in the CD4+ TCR pathway 22 711 31 -0.017 0.093 1000 -1000 -0.038 -1000
IL27-mediated signaling events 22 1143 51 -0.015 0.064 1000 -1000 -0.04 -1000
E-cadherin signaling events 22 110 5 0.033 0.062 1000 -1000 0.033 -1000
Coregulation of Androgen receptor activity 21 1656 76 -0.011 0.07 1000 -1000 -0.015 -1000
RXR and RAR heterodimerization with other nuclear receptor 21 1135 52 -0.043 0.1 1000 -1000 -0.015 -1000
Atypical NF-kappaB pathway 21 661 31 -0.021 0.036 1000 -1000 -0.013 -1000
Regulation of Androgen receptor activity 20 1449 70 -0.031 0.067 1000 -1000 -0.025 -1000
Signaling events mediated by HDAC Class II 19 1461 75 -0.03 0.093 1000 -1000 -0.025 -1000
Arf1 pathway 19 1050 54 -0.075 0.044 1000 -1000 -0.01 -1000
Canonical NF-kappaB pathway 18 705 39 -0.033 0.065 1000 -1000 -0.017 -1000
Cellular roles of Anthrax toxin 18 712 39 -0.069 0.036 1000 -1000 -0.012 -1000
Signaling events mediated by the Hedgehog family 17 888 52 -0.014 0.09 1000 -1000 -0.018 -1000
ceramide signaling pathway 17 859 49 -0.014 0.053 1000 -1000 -0.021 -1000
Signaling mediated by p38-alpha and p38-beta 17 781 44 -0.015 0.086 1000 -1000 -0.015 -1000
Sumoylation by RanBP2 regulates transcriptional repression 17 466 27 -0.032 0.077 1000 -1000 -0.025 -1000
VEGFR1 specific signals 17 989 56 -0.032 0.041 1000 -1000 -0.026 -1000
Nephrin/Neph1 signaling in the kidney podocyte 15 517 34 -0.054 0.096 1000 -1000 -0.038 -1000
Rapid glucocorticoid signaling 15 315 20 -0.011 0.036 1000 -1000 -0.01 -1000
FOXA2 and FOXA3 transcription factor networks 12 576 46 0 0.094 1000 -1000 -0.035 -1000
Aurora C signaling 10 75 7 0 0.063 1000 -1000 -0.004 -1000
Class IB PI3K non-lipid kinase events 9 27 3 -0.036 0.036 1000 -1000 -0.034 -1000
LPA4-mediated signaling events 8 104 12 -0.017 0.018 1000 -1000 -0.012 -1000
Visual signal transduction: Rods 8 440 52 -0.033 0.084 1000 -1000 -0.01 -1000
Ephrin A reverse signaling 2 18 7 -0.019 0.048 1000 -1000 -0.011 -1000
Total 5150 289493 7203 -6.9 8.6 131000 -131000 -3.1 -131000
HIF-1-alpha transcription factor network

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 0.027 0.46 0.59 100 -0.74 88 188
HDAC7 -0.001 0.005 -10000 0 -0.049 3 3
HIF1A/ARNT/Cbp/p300/Src-1 -0.025 0.38 0.56 54 -0.68 75 129
SMAD4 0.033 0.014 0.079 10 -10000 0 10
ID2 0.048 0.47 0.62 105 -0.74 86 191
AP1 0.015 0.079 -10000 0 -0.17 71 71
ABCG2 0.014 0.46 0.6 100 -0.74 88 188
HIF1A 0.044 0.13 0.23 87 -0.15 64 151
TFF3 0.043 0.46 0.6 112 -0.73 85 197
GATA2 0.039 0.014 0.077 15 -0.079 2 17
AKT1 0.052 0.13 0.24 93 -0.18 42 135
response to hypoxia 0.011 0.088 0.16 85 -0.12 52 137
MCL1 0.055 0.47 0.6 118 -0.74 87 205
NDRG1 -0.001 0.45 0.58 90 -0.74 93 183
SERPINE1 -0.065 0.38 0.55 45 -0.75 83 128
FECH 0.044 0.46 0.6 110 -0.72 87 197
FURIN 0.051 0.47 0.6 116 -0.73 87 203
NCOA2 0.037 0.006 -10000 0 -10000 0 0
EP300 0.073 0.18 0.35 96 -0.3 28 124
HMOX1 -0.019 0.45 0.6 77 -0.77 87 164
BHLHE40 -0.054 0.4 0.54 75 -0.7 93 168
BHLHE41 -0.054 0.4 0.54 75 -0.7 93 168
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.07 0.18 0.35 46 -0.24 32 78
ENG 0.03 0.15 0.29 52 -0.25 17 69
JUN 0.035 0.013 -10000 0 -0.052 2 2
RORA 0.024 0.46 0.6 101 -0.74 88 189
ABCB1 -0.055 0.21 -10000 0 -0.83 29 29
TFRC 0.033 0.46 0.6 109 -0.74 88 197
CXCR4 0.016 0.46 0.6 99 -0.75 92 191
TF -0.078 0.4 0.63 41 -0.74 90 131
CITED2 0.014 0.45 0.59 96 -0.74 88 184
HIF1A/ARNT -0.073 0.44 0.64 33 -0.85 79 112
LDHA -0.066 0.28 -10000 0 -0.96 40 40
ETS1 0.059 0.47 0.6 122 -0.73 87 209
PGK1 0.048 0.48 0.6 118 -0.75 87 205
NOS2 -0.054 0.4 0.54 75 -0.7 93 168
ITGB2 0.006 0.46 0.59 97 -0.76 88 185
ALDOA 0.055 0.47 0.6 121 -0.73 89 210
Cbp/p300/CITED2 -0.021 0.45 0.58 81 -0.78 86 167
FOS 0.026 0.018 -10000 0 -0.043 1 1
HK2 0.058 0.48 0.6 123 -0.73 89 212
SP1 0.033 0.059 0.11 40 -0.15 40 80
GCK 0.1 0.24 0.55 59 -0.51 7 66
HK1 0.002 0.44 0.63 77 -0.74 86 163
NPM1 0.053 0.47 0.62 105 -0.74 86 191
EGLN1 0.05 0.47 0.62 102 -0.74 86 188
CREB1 0.032 0.034 -10000 0 -0.1 30 30
PGM1 0.052 0.47 0.6 120 -0.74 87 207
SMAD3 0.037 0.008 0.079 10 -10000 0 10
EDN1 0.057 0.21 0.51 16 -0.61 12 28
IGFBP1 -0.01 0.41 0.63 58 -0.74 76 134
VEGFA -0.016 0.34 0.47 83 -0.56 84 167
HIF1A/JAB1 0.045 0.1 0.2 57 -0.17 21 78
CP -0.033 0.44 0.58 76 -0.75 93 169
CXCL12 -0.033 0.41 0.6 52 -0.73 86 138
COPS5 0.036 0.006 -10000 0 -10000 0 0
SMAD3/SMAD4 0.039 0.052 0.14 5 -0.14 35 40
BNIP3 -0.005 0.44 0.61 88 -0.73 89 177
EGLN3 0.006 0.45 0.59 90 -0.74 86 176
CA9 -0.015 0.42 0.58 74 -0.74 84 158
TERT 0.051 0.47 0.6 122 -0.73 87 209
ENO1 0.049 0.47 0.6 121 -0.74 86 207
PFKL 0.055 0.47 0.6 120 -0.74 85 205
NCOA1 0.033 0.011 -10000 0 -10000 0 0
ADM -0.018 0.45 0.6 81 -0.74 95 176
ARNT 0.047 0.13 0.23 91 -0.14 74 165
HNF4A 0.038 0.01 0.084 6 -10000 0 6
ADFP -0.029 0.44 0.61 61 -0.75 90 151
SLC2A1 0.015 0.37 0.53 76 -0.59 82 158
LEP 0.009 0.42 0.62 73 -0.73 78 151
HIF1A/ARNT/Cbp/p300 -0.036 0.38 0.56 53 -0.69 77 130
EPO 0.021 0.31 0.55 51 -0.58 42 93
CREBBP 0.078 0.18 0.35 99 -0.27 27 126
HIF1A/ARNT/Cbp/p300/HDAC7 -0.041 0.37 0.53 52 -0.67 78 130
PFKFB3 0.009 0.45 0.61 93 -0.75 84 177
NT5E -0.026 0.44 0.62 65 -0.73 94 159
FOXM1 transcription factor network

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 -0.087 0.66 0.99 34 -1.2 96 130
PLK1 0.061 0.16 0.7 11 -0.88 4 15
BIRC5 -0.062 0.44 0.67 14 -1.2 57 71
HSPA1B -0.088 0.65 0.92 40 -1.2 101 141
MAP2K1 0.045 0.1 0.24 59 -10000 0 59
BRCA2 -0.086 0.66 1 33 -1.2 95 128
FOXM1 -0.23 0.97 1.1 34 -1.9 101 135
XRCC1 -0.084 0.66 1 34 -1.2 94 128
FOXM1B/p19 -0.32 0.57 -10000 0 -1.4 99 99
Cyclin D1/CDK4 -0.11 0.59 0.85 30 -1.1 102 132
CDC2 -0.11 0.73 1.1 36 -1.3 102 138
TGFA -0.071 0.58 0.85 41 -1 100 141
SKP2 -0.089 0.66 0.99 34 -1.2 96 130
CCNE1 0.024 0.037 0.1 22 -0.034 114 136
CKS1B -0.097 0.68 1 34 -1.2 102 136
RB1 -0.073 0.37 0.48 17 -1 47 64
FOXM1C/SP1 -0.17 0.76 0.89 28 -1.5 103 131
AURKB 0.061 0.15 0.66 14 -0.97 2 16
CENPF -0.11 0.71 1.1 36 -1.2 111 147
CDK4 0.025 0.052 0.15 31 -10000 0 31
MYC -0.1 0.56 0.8 36 -1 107 143
CHEK2 0.037 0.092 0.23 51 -10000 0 51
ONECUT1 -0.089 0.63 0.89 40 -1.2 101 141
CDKN2A 0.003 0.018 -10000 0 -0.13 4 4
LAMA4 -0.092 0.66 0.97 35 -1.2 96 131
FOXM1B/HNF6 -0.16 0.77 0.94 35 -1.5 101 136
FOS -0.15 0.7 0.98 33 -1.2 124 157
SP1 0.034 0.019 0.072 3 -0.045 24 27
CDC25B -0.093 0.67 0.97 36 -1.2 99 135
response to radiation 0.023 0.067 0.14 79 -10000 0 79
CENPB -0.085 0.67 0.96 39 -1.2 97 136
CENPA -0.09 0.67 1 34 -1.2 95 129
NEK2 -0.079 0.67 1.1 34 -1.2 100 134
HIST1H2BA -0.088 0.65 0.92 40 -1.2 101 141
CCNA2 0.022 0.031 0.096 4 -0.034 79 83
EP300 0.033 0.011 -10000 0 0 49 49
CCNB1/CDK1 -0.19 0.84 1.1 29 -1.6 109 138
CCNB2 -0.11 0.69 1 37 -1.3 104 141
CCNB1 -0.12 0.74 1.1 37 -1.4 106 143
ETV5 -0.12 0.69 0.98 34 -1.2 118 152
ESR1 -0.09 0.65 0.98 33 -1.2 95 128
CCND1 -0.098 0.62 0.89 39 -1.1 102 141
GSK3A 0.037 0.084 0.2 55 -10000 0 55
Cyclin A-E1/CDK1-2 0.047 0.1 0.25 24 -0.16 42 66
CDK2 0.024 0.037 0.1 16 -0.034 120 136
G2/M transition of mitotic cell cycle 0.027 0.081 0.18 77 -10000 0 77
FOXM1B/Cbp/p300 -0.16 0.68 0.79 19 -1.4 101 120
GAS1 -0.092 0.67 1 36 -1.2 98 134
MMP2 -0.11 0.7 1 36 -1.2 111 147
RB1/FOXM1C -0.14 0.61 0.84 25 -1.2 100 125
CREBBP 0.036 0.005 -10000 0 -10000 0 0
Syndecan-4-mediated signaling events

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.031 0.16 -10000 0 -0.48 38 38
Syndecan-4/Syndesmos -0.14 0.28 -10000 0 -0.48 149 149
positive regulation of JNK cascade -0.13 0.26 -10000 0 -0.49 124 124
Syndecan-4/ADAM12 -0.13 0.29 -10000 0 -0.52 125 125
CCL5 0.033 0.011 -10000 0 0 53 53
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
DNM2 0.035 0.009 -10000 0 0 29 29
ITGA5 0.033 0.011 -10000 0 0 56 56
SDCBP 0.035 0.007 -10000 0 0 21 21
PLG 0.03 0.021 -10000 0 -0.044 26 26
ADAM12 0.024 0.017 -10000 0 0 168 168
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.025 0.022 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.14 0.28 -10000 0 -0.48 149 149
Syndecan-4/CXCL12/CXCR4 -0.14 0.28 -10000 0 -0.53 122 122
Syndecan-4/Laminin alpha3 -0.13 0.29 -10000 0 -0.49 143 143
MDK 0.03 0.014 -10000 0 0 92 92
Syndecan-4/FZD7 -0.14 0.3 -10000 0 -0.5 152 152
Syndecan-4/Midkine -0.13 0.3 -10000 0 -0.49 154 154
FZD7 0.026 0.016 -10000 0 0 143 143
Syndecan-4/FGFR1/FGF -0.098 0.28 -10000 0 -0.47 136 136
THBS1 0.03 0.014 -10000 0 0 97 97
integrin-mediated signaling pathway -0.13 0.28 -10000 0 -0.45 171 171
positive regulation of MAPKKK cascade -0.13 0.26 -10000 0 -0.49 124 124
Syndecan-4/TACI -0.12 0.3 -10000 0 -0.48 149 149
CXCR4 0.029 0.015 -10000 0 0 103 103
cell adhesion -0.009 0.054 0.2 3 -0.25 17 20
Syndecan-4/Dynamin -0.12 0.29 -10000 0 -0.48 146 146
Syndecan-4/TSP1 -0.13 0.28 -10000 0 -0.5 137 137
Syndecan-4/GIPC -0.12 0.29 -10000 0 -0.48 146 146
Syndecan-4/RANTES -0.13 0.29 -10000 0 -0.49 144 144
ITGB1 0.027 0.016 -10000 0 0 138 138
LAMA1 0 0 -10000 0 -10000 0 0
LAMA3 0.033 0.011 -10000 0 0 48 48
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCA 0.001 0.11 0.98 6 -10000 0 6
Syndecan-4/alpha-Actinin -0.14 0.3 -10000 0 -0.5 151 151
TFPI 0.029 0.015 -10000 0 0 103 103
F2 0.01 0.041 -10000 0 -0.045 168 168
alpha5/beta1 Integrin 0.029 0.042 -10000 0 -0.14 20 20
positive regulation of cell adhesion -0.13 0.27 -10000 0 -0.45 162 162
ACTN1 0.028 0.016 -10000 0 0 119 119
TNC 0.028 0.016 -10000 0 0 122 122
Syndecan-4/CXCL12 -0.14 0.28 -10000 0 -0.53 121 121
FGF6 0.035 0.008 -10000 0 0 27 27
RHOA 0.035 0.007 -10000 0 0 18 18
CXCL12 0.022 0.018 -10000 0 0 202 202
TNFRSF13B 0.036 0.005 -10000 0 0 8 8
FGF2 0.035 0.008 -10000 0 0 25 25
FGFR1 0.036 0.005 -10000 0 0 9 9
Syndecan-4/PI-4-5-P2 -0.14 0.28 -10000 0 -0.48 149 149
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.03 0.021 -10000 0 -0.045 27 27
cell migration -0.011 0.016 -10000 0 -10000 0 0
PRKCD 0.031 0.021 -10000 0 -0.044 24 24
vasculogenesis -0.13 0.27 -10000 0 -0.45 154 154
SDC4 -0.14 0.3 -10000 0 -0.49 167 167
Syndecan-4/Tenascin C -0.14 0.3 -10000 0 -0.5 153 153
Syndecan-4/PI-4-5-P2/PKC alpha -0.02 0.018 -10000 0 -10000 0 0
Syndecan-4/Syntenin -0.13 0.3 -10000 0 -0.49 146 146
MMP9 0.012 0.024 -10000 0 -0.042 38 38
Rac1/GTP -0.009 0.055 0.2 3 -0.26 17 20
cytoskeleton organization -0.13 0.27 -10000 0 -0.46 149 149
GIPC1 0.035 0.008 -10000 0 0 24 24
Syndecan-4/TFPI -0.13 0.29 -10000 0 -0.5 145 145
Angiopoietin receptor Tie2-mediated signaling

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.23 0.41 -10000 0 -0.82 142 142
NCK1/PAK1/Dok-R -0.12 0.17 -10000 0 -0.38 130 130
NCK1/Dok-R -0.14 0.35 -10000 0 -0.86 96 96
PIK3CA 0.031 0.013 -10000 0 0 80 80
mol:beta2-estradiol 0.032 0.098 0.23 96 -10000 0 96
RELA 0.036 0.005 -10000 0 0 9 9
SHC1 0.032 0.011 -10000 0 0 52 52
Rac/GDP 0.017 0.019 -10000 0 -0.13 5 5
F2 0.053 0.11 0.28 87 -0.09 64 151
TNIP2 0.036 0.006 -10000 0 0 13 13
NF kappa B/RelA -0.12 0.36 -10000 0 -0.83 96 96
FN1 0.035 0.009 -10000 0 0 29 29
PLD2 -0.15 0.36 -10000 0 -0.89 96 96
PTPN11 0.036 0.005 -10000 0 0 11 11
GRB14 0.032 0.013 -10000 0 0 70 70
ELK1 -0.15 0.33 -10000 0 -0.82 96 96
GRB7 0.036 0.006 -10000 0 0 14 14
PAK1 0.036 0.006 -10000 0 0 15 15
Tie2/Ang1/alpha5/beta1 Integrin -0.13 0.36 -10000 0 -0.86 96 96
CDKN1A -0.19 0.35 -10000 0 -0.66 164 164
ITGA5 0.033 0.011 -10000 0 0 56 56
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.14 0.36 -10000 0 -0.86 96 96
CRK 0.035 0.008 -10000 0 0 23 23
mol:NO -0.12 0.32 0.37 3 -0.58 143 146
PLG -0.15 0.36 -10000 0 -0.89 96 96
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis -0.17 0.37 -10000 0 -0.75 123 123
GRB2 0.035 0.007 -10000 0 0 17 17
PIK3R1 0.032 0.012 -10000 0 0 63 63
ANGPT2 -0.22 0.45 -10000 0 -1 107 107
BMX -0.15 0.36 -10000 0 -0.89 96 96
ANGPT1 -0.16 0.42 -10000 0 -1 95 95
tube development -0.21 0.36 -10000 0 -0.7 162 162
ANGPT4 0.023 0.028 -10000 0 -0.03 107 107
response to hypoxia -0.013 0.026 -10000 0 -0.063 96 96
Tie2/Ang1/GRB14 -0.14 0.37 -10000 0 -0.9 96 96
alpha5/beta1 Integrin 0.029 0.042 -10000 0 -0.14 20 20
FGF2 0.035 0.016 -10000 0 -0.012 43 43
STAT5A (dimer) -0.24 0.44 -10000 0 -0.82 170 170
mol:L-citrulline -0.12 0.32 0.37 3 -0.58 143 146
AGTR1 0.022 0.034 -10000 0 -0.048 90 90
MAPK14 -0.16 0.37 -10000 0 -0.9 96 96
Tie2/SHP2 -0.079 0.24 -10000 0 -0.85 32 32
TEK -0.087 0.25 -10000 0 -0.96 30 30
RPS6KB1 -0.2 0.37 -10000 0 -0.77 136 136
Angiotensin II/AT1 0.015 0.036 0.076 7 -0.055 90 97
Tie2/Ang1/GRB2 -0.14 0.38 -10000 0 -0.91 96 96
MAPK3 -0.15 0.34 -10000 0 -0.84 96 96
MAPK1 -0.15 0.34 -10000 0 -0.84 96 96
Tie2/Ang1/GRB7 -0.14 0.38 -10000 0 -0.91 96 96
NFKB1 0.035 0.007 -10000 0 0 18 18
MAPK8 -0.16 0.36 -10000 0 -0.88 96 96
PI3K -0.24 0.44 -10000 0 -0.9 136 136
FES -0.16 0.38 -10000 0 -0.9 97 97
Crk/Dok-R -0.14 0.36 -10000 0 -0.86 96 96
Tie2/Ang1/ABIN2 -0.14 0.38 -10000 0 -0.9 96 96
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity -0.2 0.36 -10000 0 -0.73 144 144
STAT5A 0.036 0.004 -10000 0 0 5 5
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 -0.2 0.37 -10000 0 -0.77 135 135
Tie2/Ang2 -0.29 0.5 -10000 0 -0.98 160 160
Tie2/Ang1 -0.15 0.38 -10000 0 -0.93 96 96
FOXO1 -0.22 0.39 -10000 0 -0.75 166 166
ELF1 0.028 0.036 0.11 4 -0.046 81 85
ELF2 -0.14 0.36 -10000 0 -0.87 96 96
mol:Choline -0.15 0.35 -10000 0 -0.86 96 96
cell migration -0.066 0.097 -10000 0 -0.21 137 137
FYN -0.24 0.41 -10000 0 -0.81 162 162
DOK2 0 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.17 0.32 0.39 3 -0.59 168 171
ETS1 -0.002 0.12 0.12 2 -0.25 93 95
PXN -0.17 0.31 0.36 1 -0.65 134 135
ITGB1 0.027 0.016 -10000 0 0 138 138
NOS3 -0.15 0.35 0.4 1 -0.67 136 137
RAC1 0.024 0.017 -10000 0 0 173 173
TNF -0.004 0.12 -10000 0 -0.25 92 92
MAPKKK cascade -0.15 0.35 -10000 0 -0.86 96 96
RASA1 0.034 0.009 -10000 0 0 32 32
Tie2/Ang1/Shc -0.15 0.37 -10000 0 -0.91 96 96
NCK1 0.035 0.008 -10000 0 0 27 27
vasculogenesis -0.1 0.29 0.35 5 -0.52 143 148
mol:Phosphatidic acid -0.15 0.35 -10000 0 -0.86 96 96
mol:Angiotensin II -0.004 0.013 -10000 0 -0.032 73 73
mol:NADP -0.12 0.32 0.37 3 -0.58 143 146
Rac1/GTP -0.18 0.34 -10000 0 -0.7 132 132
MMP2 -0.15 0.37 -10000 0 -0.9 96 96
Endothelins

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.02 0.14 0.21 76 -0.26 85 161
PTK2B 0.036 0.006 -10000 0 0 16 16
mol:Ca2+ -0.1 0.25 0.38 3 -0.52 84 87
EDN1 0.005 0.092 0.15 2 -0.16 101 103
EDN3 0.033 0.011 -10000 0 0 52 52
EDN2 0.036 0.006 -10000 0 0 12 12
HRAS/GDP -0.016 0.17 0.31 17 -0.37 57 74
ETA receptor/Endothelin-1/Gq/GTP/PLC beta 0 0.12 0.2 17 -0.25 55 72
ADCY4 -0.035 0.097 0.14 37 -0.2 96 133
ADCY5 -0.035 0.097 0.14 37 -0.2 96 133
ADCY6 -0.007 0.13 0.19 87 -0.23 64 151
ADCY7 -0.014 0.13 0.2 49 -0.24 66 115
ADCY1 -0.002 0.11 0.2 39 -0.25 42 81
ADCY2 -0.007 0.13 0.19 85 -0.24 65 150
ADCY3 -0.035 0.097 0.14 37 -0.2 96 133
ADCY8 -0.011 0.12 0.2 55 -0.23 57 112
ADCY9 -0.009 0.13 0.2 61 -0.23 66 127
arachidonic acid secretion -0.08 0.26 0.31 28 -0.52 99 127
ETB receptor/Endothelin-1/Gq/GTP -0.007 0.11 0.19 10 -0.25 47 57
GNAO1 0.03 0.014 -10000 0 0 87 87
HRAS 0.034 0.009 -10000 0 0 32 32
ETA receptor/Endothelin-1/G12/GTP 0.004 0.12 -10000 0 -0.23 71 71
ETA receptor/Endothelin-1/Gs/GTP 0.005 0.12 -10000 0 -0.21 102 102
mol:GTP 0 0.006 0.026 3 -0.025 4 7
COL3A1 -0.074 0.15 0.19 8 -0.36 100 108
EDNRB 0.023 0.045 0.096 62 -0.082 48 110
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.017 0.14 0.21 75 -0.28 63 138
CYSLTR1 -0.034 0.12 0.19 41 -0.24 93 134
SLC9A1 -0.014 0.086 0.13 5 -0.18 67 72
mol:GDP -0.024 0.17 0.29 21 -0.38 55 76
SLC9A3 -0.12 0.29 -10000 0 -0.66 81 81
RAF1 -0.036 0.2 0.31 24 -0.41 82 106
JUN -0.14 0.33 0.5 1 -0.71 87 88
JAK2 -0.021 0.14 0.21 66 -0.26 85 151
mol:IP3 -0.004 0.12 0.22 16 -0.29 38 54
ETA receptor/Endothelin-1 -0.02 0.15 -10000 0 -0.28 107 107
PLCB1 0.033 0.013 -10000 0 -0.008 38 38
PLCB2 0.028 0.023 -10000 0 -0.022 80 80
ETA receptor/Endothelin-3 0.008 0.087 -10000 0 -0.14 103 103
FOS -0.094 0.35 0.41 16 -0.84 82 98
Gai/GDP -0.068 0.27 -10000 0 -0.73 66 66
CRK 0.035 0.008 -10000 0 0 23 23
mol:Ca ++ -0.02 0.17 0.25 54 -0.34 75 129
BCAR1 0 0 -10000 0 -10000 0 0
PRKCB1 -0.004 0.12 0.23 25 -0.3 42 67
GNAQ 0.027 0.026 -10000 0 -0.034 70 70
GNAZ 0.031 0.013 -10000 0 0 81 81
GNAL 0.036 0.006 -10000 0 0 13 13
Gs family/GDP -0.014 0.16 0.29 18 -0.35 55 73
ETA receptor/Endothelin-1/Gq/GTP -0.006 0.12 0.22 9 -0.28 54 63
MAPK14 -0.014 0.099 0.17 10 -0.25 45 55
TRPC6 -0.1 0.26 0.4 1 -0.55 82 83
GNAI2 0.034 0.01 -10000 0 0 43 43
GNAI3 0.036 0.006 -10000 0 0 15 15
GNAI1 0.018 0.018 -10000 0 0 263 263
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.004 0.1 0.18 15 -0.24 46 61
ETB receptor/Endothelin-2 0.017 0.071 -10000 0 -0.11 89 89
ETB receptor/Endothelin-3 0.016 0.069 -10000 0 -0.11 84 84
ETB receptor/Endothelin-1 0 0.1 0.18 9 -0.17 96 105
MAPK3 -0.077 0.32 0.39 18 -0.73 82 100
MAPK1 -0.091 0.34 0.39 18 -0.79 82 100
Rac1/GDP -0.012 0.15 0.31 15 -0.38 39 54
cAMP biosynthetic process 0.02 0.12 0.22 58 -0.21 47 105
MAPK8 -0.14 0.31 0.36 1 -0.59 133 134
SRC 0.036 0.006 -10000 0 0 14 14
ETB receptor/Endothelin-1/Gi/GTP -0.029 0.14 0.15 9 -0.34 59 68
p130Cas/CRK/Src/PYK2 -0.024 0.18 0.35 13 -0.47 43 56
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.015 0.15 0.3 14 -0.38 43 57
COL1A2 -0.052 0.17 -10000 0 -0.48 59 59
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 0.006 0.091 -10000 0 -0.14 114 114
mol:DAG -0.004 0.12 0.22 16 -0.29 38 54
MAP2K2 -0.052 0.26 0.34 36 -0.56 81 117
MAP2K1 -0.064 0.26 0.34 20 -0.58 84 104
EDNRA -0.008 0.1 0.16 1 -0.2 99 100
positive regulation of muscle contraction 0.033 0.15 0.22 148 -0.26 45 193
Gq family/GDP 0.002 0.16 0.3 6 -0.35 54 60
HRAS/GTP -0.016 0.16 0.28 24 -0.36 56 80
PRKCH -0.009 0.12 0.25 16 -0.3 39 55
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCA -0.012 0.12 0.23 15 -0.3 42 57
PRKCB -0.008 0.12 0.22 17 -0.28 45 62
PRKCE -0.013 0.12 0.22 17 -0.3 43 60
PRKCD -0.007 0.12 0.25 24 -0.29 42 66
PRKCG -0.014 0.12 0.22 16 -0.3 46 62
regulation of vascular smooth muscle contraction -0.12 0.41 0.45 11 -1 82 93
PRKCQ -0.003 0.11 0.25 19 -0.3 32 51
PLA2G4A -0.09 0.28 0.32 25 -0.56 100 125
GNA14 0.027 0.026 -10000 0 -0.034 70 70
GNA15 0.03 0.019 -10000 0 -0.034 25 25
GNA12 0.023 0.018 -10000 0 0 193 193
GNA11 0.031 0.017 -10000 0 -0.035 16 16
Rac1/GTP 0.006 0.11 -10000 0 -0.22 68 68
MMP1 0.019 0.074 0.22 10 -10000 0 10
TCGA08_rtk_signaling

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.025 0.017 -10000 0 0 167 167
HRAS 0.034 0.009 -10000 0 0 32 32
EGFR 0.009 0.016 -10000 0 0 381 381
AKT 0.09 0.12 0.24 130 -0.18 10 140
FOXO3 0 0 -10000 0 -10000 0 0
AKT1 0.033 0.011 -10000 0 0 53 53
FOXO1 0 0 -10000 0 -10000 0 0
AKT3 0.035 0.008 -10000 0 0 23 23
FOXO4 0 0 -10000 0 -10000 0 0
MET 0.023 0.018 -10000 0 0 191 191
PIK3CA 0.031 0.013 -10000 0 0 80 80
PIK3CB 0.035 0.007 -10000 0 0 18 18
NRAS 0.032 0.012 -10000 0 0 63 63
PIK3CG 0.025 0.017 -10000 0 0 163 163
PIK3R3 0.036 0.006 -10000 0 0 15 15
PIK3R2 0.035 0.008 -10000 0 0 23 23
NF1 0.036 0.003 -10000 0 0 4 4
RAS -0.003 0.057 0.14 3 -0.13 50 53
ERBB2 0.036 0.004 -10000 0 0 5 5
proliferation/survival/translation -0.024 0.051 0.22 4 -0.19 15 19
PI3K 0.041 0.092 0.22 79 -0.15 12 91
PIK3R1 0.032 0.012 -10000 0 0 63 63
KRAS 0.034 0.009 -10000 0 0 35 35
FOXO 0.093 0.091 0.2 170 -10000 0 170
AKT2 0.035 0.008 -10000 0 0 28 28
PTEN 0.026 0.017 -10000 0 0 148 148
Thromboxane A2 receptor signaling

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 0.035 0.008 -10000 0 0 23 23
GNB1/GNG2 -0.046 0.078 -10000 0 -0.17 131 131
AKT1 -0.003 0.16 0.27 37 -0.31 35 72
EGF 0.035 0.008 -10000 0 0 25 25
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR -0.015 0.07 0.26 22 -0.16 4 26
mol:Ca2+ -0.001 0.19 0.34 28 -0.27 125 153
LYN -0.015 0.07 0.26 21 -0.16 7 28
RhoA/GTP 0.002 0.084 0.15 29 -0.13 87 116
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.017 0.21 0.36 30 -0.32 126 156
GNG2 0 0 -10000 0 -10000 0 0
ARRB2 0.035 0.008 -10000 0 0 26 26
TP alpha/Gq family/GDP/G beta5/gamma2 0.001 0.078 -10000 0 -0.24 35 35
G beta5/gamma2 -0.054 0.1 -10000 0 -0.22 130 130
PRKCH -0.016 0.21 0.36 27 -0.32 127 154
DNM1 0.035 0.008 -10000 0 0 26 26
TXA2/TP beta/beta Arrestin3 0.014 0.018 -10000 0 -10000 0 0
mol:GTP 0.001 0.002 0.006 57 -0.002 5 62
PTGDR 0.035 0.008 -10000 0 0 26 26
G12 family/GTP -0.045 0.14 -10000 0 -0.29 93 93
ADRBK1 0.036 0.006 -10000 0 0 13 13
ADRBK2 0.035 0.009 -10000 0 0 29 29
RhoA/GTP/ROCK1 0.044 0.026 -10000 0 -0.12 10 10
mol:GDP -0.008 0.13 0.4 16 -0.27 22 38
mol:NADP 0.024 0.017 -10000 0 0 175 175
RAB11A 0.035 0.007 -10000 0 0 18 18
PRKG1 0.027 0.017 -10000 0 0 141 141
mol:IP3 -0.013 0.22 0.38 25 -0.34 125 150
cell morphogenesis 0.044 0.026 -10000 0 -0.12 10 10
PLCB2 -0.037 0.27 0.42 19 -0.45 125 144
mol:cGMP 0 0.001 -10000 0 -10000 0 0
BLK -0.013 0.072 0.24 28 -10000 0 28
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK -0.018 0.06 0.25 14 -0.16 9 23
RHOA 0.035 0.007 -10000 0 0 18 18
PTGIR 0.034 0.009 -10000 0 0 33 33
PRKCB1 -0.017 0.22 0.37 25 -0.34 125 150
GNAQ 0.034 0.009 -10000 0 0 31 31
mol:L-citrulline 0.024 0.017 -10000 0 0 175 175
TXA2/TXA2-R family -0.048 0.28 0.41 24 -0.47 133 157
LCK -0.015 0.07 0.26 22 -10000 0 22
TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.033 0.038 0.19 5 -0.12 1 6
TXA2-R family/G12 family/GDP/G beta/gamma -0.02 0.14 -10000 0 -0.46 45 45
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.03 0.041 0.19 5 -0.14 2 7
MAPK14 -0.004 0.15 0.28 37 -0.22 122 159
TGM2/GTP -0.012 0.24 0.41 24 -0.38 92 116
MAPK11 -0.006 0.15 0.28 35 -0.22 122 157
ARHGEF1 0.011 0.12 0.22 50 -0.18 89 139
GNAI2 0.034 0.01 -10000 0 0 43 43
JNK cascade -0.021 0.22 0.38 25 -0.35 133 158
RAB11/GDP 0.034 0.01 -10000 0 -0.009 25 25
ICAM1 -0.005 0.18 0.31 39 -0.27 126 165
cAMP biosynthetic process -0.013 0.2 0.35 25 -0.32 94 119
Gq family/GTP/EBP50 0.013 0.051 0.24 7 -0.15 30 37
actin cytoskeleton reorganization 0.044 0.026 -10000 0 -0.12 10 10
SRC -0.018 0.062 0.24 18 -10000 0 18
GNB5 0.035 0.008 -10000 0 0 24 24
GNB1 0.035 0.007 -10000 0 0 20 20
EGF/EGFR -0.011 0.1 0.26 23 -0.22 43 66
VCAM1 -0.023 0.21 0.32 36 -0.33 135 171
TP beta/Gq family/GDP/G beta5/gamma2 0.001 0.078 -10000 0 -0.24 35 35
platelet activation -0.009 0.19 0.35 32 -0.28 121 153
PGI2/IP 0.025 0.007 -10000 0 -10000 0 0
PRKACA 0.015 0.02 -10000 0 -10000 0 0
Gq family/GDP/G beta5/gamma2 0.004 0.069 -10000 0 -0.21 33 33
TXA2/TP beta/beta Arrestin2 0.004 0.047 -10000 0 -0.26 10 10
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.006 0.02 -10000 0 -10000 0 0
mol:DAG -0.022 0.24 0.39 25 -0.38 127 152
EGFR 0.009 0.016 -10000 0 0 381 381
TXA2/TP alpha -0.029 0.26 0.42 19 -0.42 107 126
Gq family/GTP 0.009 0.048 0.2 12 -0.13 26 38
YES1 -0.014 0.071 0.26 23 -0.16 3 26
GNAI2/GTP 0.008 0.048 -10000 0 -0.13 3 3
PGD2/DP 0.026 0.006 -10000 0 -10000 0 0
SLC9A3R1 0.034 0.01 -10000 0 0 37 37
FYN -0.015 0.072 0.26 21 -0.16 13 34
mol:NO 0.024 0.017 -10000 0 0 175 175
GNA15 0.033 0.012 -10000 0 0 57 57
PGK/cGMP 0.027 0.025 -10000 0 -10000 0 0
RhoA/GDP 0.034 0.01 -10000 0 -0.009 25 25
TP alpha/TGM2/GDP/G beta/gamma 0.031 0.042 0.18 4 -0.14 2 6
NOS3 0.024 0.017 -10000 0 0 175 175
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCA -0.015 0.21 0.35 28 -0.32 126 154
PRKCB -0.016 0.21 0.35 26 -0.32 131 157
PRKCE -0.018 0.21 0.36 26 -0.33 127 153
PRKCD -0.019 0.22 0.36 30 -0.35 129 159
PRKCG -0.022 0.22 0.37 25 -0.35 131 156
muscle contraction -0.042 0.26 0.4 24 -0.44 133 157
PRKCZ -0.016 0.2 0.35 27 -0.31 133 160
ARR3 0.037 0 -10000 0 -10000 0 0
TXA2/TP beta 0.036 0.039 0.19 4 -0.13 2 6
PRKCQ -0.026 0.2 0.35 27 -0.32 124 151
MAPKKK cascade -0.032 0.24 0.39 24 -0.4 125 149
SELE -0.01 0.18 0.32 30 -0.27 134 164
TP beta/GNAI2/GDP/G beta/gamma 0.026 0.053 0.19 4 -0.16 14 18
ROCK1 0.036 0.006 -10000 0 0 15 15
GNA14 0.034 0.009 -10000 0 0 30 30
chemotaxis -0.069 0.32 0.44 20 -0.56 135 155
GNA12 0.023 0.018 -10000 0 0 193 193
GNA13 0.035 0.007 -10000 0 0 19 19
GNA11 0.033 0.011 -10000 0 0 54 54
Rac1/GTP 0.017 0.02 -10000 0 -0.13 5 5
HIF-2-alpha transcription factor network

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 -0.019 0.17 -10000 0 -0.67 29 29
oxygen homeostasis 0.004 0.02 0.044 66 -0.024 26 92
TCEB2 0.036 0.004 -10000 0 0 6 6
TCEB1 0.035 0.007 -10000 0 0 22 22
VHL/Elongin B/Elongin C/HIF2A 0.003 0.14 0.3 23 -0.23 53 76
EPO -0.04 0.2 0.4 16 -0.42 59 75
FIH (dimer) 0.016 0.038 0.11 17 -0.039 66 83
APEX1 0.016 0.043 0.1 8 -0.049 48 56
SERPINE1 -0.074 0.2 0.32 7 -0.45 83 90
FLT1 -0.012 0.16 -10000 0 -0.67 23 23
ADORA2A -0.037 0.24 0.44 35 -0.41 76 111
germ cell development -0.036 0.23 0.43 33 -0.4 78 111
SLC11A2 -0.034 0.24 0.45 34 -0.42 77 111
BHLHE40 -0.039 0.23 0.43 32 -0.42 78 110
HIF1AN 0.016 0.038 0.11 17 -0.039 66 83
HIF2A/ARNT/SIRT1 -0.016 0.16 0.35 25 -0.29 61 86
ETS1 0.047 0.032 0.12 43 -0.11 11 54
CITED2 -0.058 0.26 -10000 0 -0.81 50 50
KDR -0.001 0.16 -10000 0 -0.83 16 16
PGK1 -0.039 0.25 0.45 34 -0.44 84 118
SIRT1 0.024 0.017 -10000 0 0 171 171
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT -0.028 0.27 0.48 12 -0.47 78 90
EPAS1 0 0.13 0.3 35 -0.22 63 98
SP1 0.041 0.011 0.11 8 -10000 0 8
ABCG2 -0.045 0.26 0.45 34 -0.44 92 126
EFNA1 -0.04 0.24 0.43 30 -0.43 80 110
FXN -0.039 0.23 0.43 35 -0.41 78 113
POU5F1 -0.039 0.23 0.43 32 -0.42 78 110
neuron apoptosis 0.027 0.26 0.46 78 -0.46 13 91
EP300 0.033 0.011 -10000 0 0 49 49
EGLN3 0.019 0.039 0.11 15 -0.039 66 81
EGLN2 0.022 0.041 0.11 20 -0.038 69 89
EGLN1 0.023 0.041 0.11 20 -0.037 94 114
VHL/Elongin B/Elongin C 0.045 0.023 -10000 0 -0.12 9 9
VHL 0 0 -10000 0 -10000 0 0
ARNT 0.016 0.043 0.11 7 -0.049 47 54
SLC2A1 -0.051 0.23 0.43 27 -0.43 81 108
TWIST1 -0.064 0.21 0.41 15 -0.43 86 101
ELK1 0.038 0.035 0.11 29 -0.095 25 54
HIF2A/ARNT/Cbp/p300 0.001 0.19 0.38 31 -0.3 62 93
VEGFA -0.039 0.23 0.43 32 -0.42 78 110
CREBBP 0.036 0.005 -10000 0 0 8 8
TCGA08_p53

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.001 0.004 0 444 -10000 0 444
TP53 0.004 0.034 -10000 0 -0.22 9 9
Senescence 0.004 0.034 -10000 0 -0.22 9 9
Apoptosis 0.004 0.034 -10000 0 -0.22 9 9
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0 0.023 0.3 3 -10000 0 3
MDM4 0.034 0.01 -10000 0 0 38 38
EGFR-dependent Endothelin signaling events

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.034 0.009 -10000 0 0 32 32
EGFR 0.009 0.016 -10000 0 0 381 381
EGF/EGFR 0.001 0.052 -10000 0 -0.11 64 64
EGF/EGFR dimer/SHC/GRB2/SOS1 0.006 0.057 -10000 0 -0.11 61 61
mol:GTP 0 0 -10000 0 -10000 0 0
EDNRA 0.028 0.016 -10000 0 0 122 122
response to oxidative stress 0 0 -10000 0 -10000 0 0
EGF 0.035 0.008 -10000 0 0 25 25
EGF/EGFR dimer/SHC 0 0.055 -10000 0 -0.12 61 61
mol:GDP 0.004 0.055 -10000 0 -0.11 61 61
mol:Ca2+ 0 0 -10000 0 -10000 0 0
EDN1 0.033 0.011 -10000 0 0 53 53
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
HRAS/GTP -0.004 0.051 -10000 0 -0.11 68 68
SHC1 0.033 0.011 -10000 0 0 52 52
HRAS/GDP 0 0.057 -10000 0 -0.12 67 67
FRAP1 0.093 0.12 0.18 302 -0.18 4 306
EGF/EGFR dimer -0.005 0.056 -10000 0 -0.14 64 64
SOS1 0 0 -10000 0 -10000 0 0
GRB2 0.035 0.007 -10000 0 0 17 17
ETA receptor/Endothelin-1 0.023 0.059 -10000 0 -0.14 50 50
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A 0.034 0.01 -10000 0 0 41 41
oxygen homeostasis 0 0 -10000 0 -10000 0 0
TCEB2 0.036 0.004 -10000 0 0 6 6
TCEB1 0.035 0.007 -10000 0 0 22 22
HIF1A/p53 -0.063 0.14 -10000 0 -0.27 140 140
HIF1A -0.057 0.12 0.16 1 -0.28 118 119
COPS5 0.036 0.006 -10000 0 0 14 14
VHL/Elongin B/Elongin C/RBX1/CUL2 0.048 0.059 -10000 0 -0.13 22 22
FIH (dimer) 0.025 0.017 -10000 0 0 156 156
CDKN2A 0.004 0.012 -10000 0 0 444 444
ARNT/IPAS 0.05 0.015 -10000 0 -10000 0 0
HIF1AN 0.025 0.017 -10000 0 0 156 156
GNB2L1 0.036 0.002 -10000 0 0 2 2
HIF1A/ARNT -0.061 0.14 -10000 0 -0.27 140 140
CUL2 0.026 0.017 -10000 0 0 153 153
OS9 0.031 0.013 -10000 0 0 73 73
RACK1/Elongin B/Elongin C 0.068 0.032 -10000 0 -0.13 10 10
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF1A/Hsp90 -0.075 0.13 -10000 0 -0.27 142 142
PHD1-3/OS9 0.063 0.064 -10000 0 -0.14 31 31
HIF1A/RACK1/Elongin B/Elongin C -0.043 0.15 -10000 0 -0.27 142 142
VHL 0 0 -10000 0 -10000 0 0
HSP90AA1 0 0 -10000 0 -10000 0 0
HIF1A/JAB1 -0.063 0.14 -10000 0 -0.27 144 144
EGLN3 0.03 0.014 -10000 0 0 91 91
EGLN2 0.034 0.009 -10000 0 0 30 30
EGLN1 0.034 0.009 -10000 0 0 33 33
TP53 0.031 0.013 -10000 0 0 73 73
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.005 0.1 -10000 0 -0.61 12 12
ARNT 0.036 0.004 -10000 0 0 5 5
ARD1A 0.036 0.003 -10000 0 0 4 4
RBX1 0.033 0.01 -10000 0 0 45 45
HIF1A/p19ARF -0.064 0.12 -10000 0 -0.26 119 119
Effects of Botulinum toxin

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A -0.007 0.006 0 180 -10000 0 180
UniProt:P19321 0 0 -10000 0 -10000 0 0
RIMS1/UNC13B 0.04 0.04 -10000 0 -0.14 19 19
STXBP1 0.029 0.015 -10000 0 0 106 106
ACh/CHRNA1 0.026 0.053 0.095 40 -0.075 91 131
RAB3GAP2/RIMS1/UNC13B 0.052 0.05 -10000 0 -0.13 25 25
mol:Ca2+ 0 0 -10000 0 -10000 0 0
UniProt:P30996 0 0 -10000 0 -10000 0 0
UniProt:Q60393 0 0 -10000 0 -10000 0 0
CST086 0 0 -10000 0 -10000 0 0
RIMS1 0.035 0.008 -10000 0 0 23 23
mol:ACh 0.016 0.063 0.093 145 -0.09 86 231
RAB3GAP2 0.035 0.009 -10000 0 0 29 29
STX1A/SNAP25/VAMP2 0.026 0.1 0.18 19 -0.16 76 95
UniProt:P10844 0 0 -10000 0 -10000 0 0
muscle contraction 0.026 0.053 0.095 40 -0.075 91 131
UNC13B 0.032 0.013 -10000 0 0 70 70
CHRNA1 0.035 0.007 -10000 0 0 18 18
UniProt:P10845 0 0 -10000 0 -10000 0 0
ACh/Synaptotagmin 1 0.012 0.041 0.096 9 -0.085 40 49
SNAP25 0.002 0.003 -10000 0 0 262 262
VAMP2 0.004 0.001 -10000 0 0 48 48
SYT1 0.018 0.018 -10000 0 0 262 262
UniProt:Q00496 0 0 -10000 0 -10000 0 0
STXIA/STXBP1 0.017 0.016 -10000 0 -10000 0 0
STX1A/SNAP25 fragment 1/VAMP2 0.026 0.1 0.18 19 -0.16 76 95
PDGFR-alpha signaling pathway

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.017 0.031 0.081 3 -0.056 51 54
PDGF/PDGFRA/CRKL 0.007 0.067 -10000 0 -0.14 68 68
positive regulation of JUN kinase activity 0.023 0.062 -10000 0 -0.11 69 69
CRKL 0.035 0.009 -10000 0 0 29 29
PDGF/PDGFRA/Caveolin-3 0.009 0.068 -10000 0 -0.14 68 68
AP1 -0.08 0.24 0.29 12 -0.59 77 89
mol:IP3 -0.015 0.046 0.095 25 -0.11 39 64
PLCG1 -0.015 0.046 0.095 25 -0.11 39 64
PDGF/PDGFRA/alphaV Integrin 0.004 0.075 -10000 0 -0.15 78 78
RAPGEF1 0.035 0.007 -10000 0 0 19 19
CRK 0.035 0.008 -10000 0 0 23 23
mol:Ca2+ -0.015 0.046 0.095 25 -0.11 39 64
CAV3 0.036 0.005 -10000 0 0 11 11
CAV1 0.016 0.018 -10000 0 0 290 290
SHC/Grb2/SOS1 0.028 0.064 -10000 0 -0.11 69 69
PDGF/PDGFRA/Shf -0.005 0.054 -10000 0 -0.089 119 119
FOS -0.093 0.22 0.42 1 -0.6 71 72
JUN -0.026 0.056 0.2 10 -0.2 16 26
oligodendrocyte development 0.003 0.075 -10000 0 -0.15 78 78
GRB2 0.035 0.007 -10000 0 0 17 17
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:DAG -0.015 0.046 0.095 25 -0.11 39 64
PDGF/PDGFRA 0.017 0.031 0.081 3 -0.056 51 54
actin cytoskeleton reorganization 0.007 0.065 -10000 0 -0.14 65 65
SRF -0.016 0.021 -10000 0 -10000 0 0
SHC1 0.033 0.011 -10000 0 0 52 52
PI3K 0.007 0.09 -10000 0 -0.15 108 108
PDGF/PDGFRA/Crk/C3G 0.027 0.071 -10000 0 -0.13 75 75
JAK1 -0.007 0.029 0.083 30 -10000 0 30
ELK1/SRF -0.02 0.083 0.14 67 -0.16 60 127
SHB 0.033 0.011 -10000 0 0 51 51
SHF 0 0 -10000 0 -10000 0 0
CSNK2A1 0.027 0.034 -10000 0 -0.032 102 102
GO:0007205 -0.027 0.068 0.1 25 -0.19 55 80
SOS1 0 0 -10000 0 -10000 0 0
Ras protein signal transduction 0.023 0.062 -10000 0 -0.11 69 69
PDGF/PDGFRA/SHB 0.007 0.065 -10000 0 -0.14 65 65
PDGF/PDGFRA/Caveolin-1 -0.016 0.077 -10000 0 -0.16 97 97
ITGAV 0.034 0.009 -10000 0 0 31 31
ELK1 -0.032 0.066 0.088 26 -0.15 94 120
PIK3CA 0.031 0.013 -10000 0 0 80 80
PDGF/PDGFRA/Crk 0.006 0.072 -10000 0 -0.15 76 76
JAK-STAT cascade -0.007 0.029 0.082 30 -10000 0 30
cell proliferation -0.005 0.054 -10000 0 -0.089 119 119
Syndecan-3-mediated signaling events

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.036 0.006 -9999 0 0 13 13
Syndecan-3/Src/Cortactin -0.025 0.18 -9999 0 -0.43 76 76
Syndecan-3/Neurocan -0.065 0.18 -9999 0 -0.48 78 78
POMC 0.036 0.006 -9999 0 0 14 14
EGFR 0.009 0.016 -9999 0 0 381 381
Syndecan-3/EGFR -0.057 0.16 -9999 0 -0.41 78 78
AGRP 0.036 0.005 -9999 0 0 9 9
NCSTN 0.035 0.008 -9999 0 0 28 28
PSENEN 0.035 0.008 -9999 0 0 28 28
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.035 0.006 -9999 0 0 16 16
APH1A 0.036 0.005 -9999 0 0 11 11
NCAN 0 0 -9999 0 -10000 0 0
long-term memory -0.033 0.2 -9999 0 -0.49 79 79
Syndecan-3/IL8 -0.056 0.18 -9999 0 -0.48 78 78
PSEN1 0.033 0.011 -9999 0 0 46 46
Src/Cortactin 0.051 0.015 -9999 0 -0.14 1 1
FYN 0.03 0.014 -9999 0 0 90 90
limb bud formation -0.066 0.18 -9999 0 -0.5 78 78
MC4R 0.035 0.007 -9999 0 0 20 20
SRC 0.036 0.006 -9999 0 0 14 14
PTN 0.021 0.018 -9999 0 0 209 209
FGFR/FGF/Syndecan-3 -0.067 0.19 -9999 0 -0.5 78 78
neuron projection morphogenesis -0.071 0.15 -9999 0 -0.42 75 75
Syndecan-3/AgRP -0.044 0.19 -9999 0 -0.48 79 79
Syndecan-3/AgRP/MC4R -0.025 0.19 -9999 0 -0.47 79 79
Fyn/Cortactin 0.029 0.061 -9999 0 -0.14 53 53
SDC3 -0.068 0.19 -9999 0 -0.51 78 78
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.055 0.18 -9999 0 -0.47 78 78
IL8 0.019 0.018 -9999 0 0 243 243
Syndecan-3/Fyn/Cortactin -0.034 0.21 -9999 0 -0.5 79 79
Syndecan-3/CASK -0.065 0.18 -9999 0 -0.48 78 78
alpha-MSH/MC4R 0.051 0.014 -9999 0 -10000 0 0
Gamma Secretase 0.08 0.069 -9999 0 -0.15 28 28
Wnt signaling

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.006 0.089 -9999 0 -0.17 89 89
FZD6 0.027 0.016 -9999 0 0 130 130
WNT6 0.037 0.002 -9999 0 0 1 1
WNT4 0.035 0.007 -9999 0 0 18 18
FZD3 0.029 0.015 -9999 0 0 110 110
WNT5A 0.029 0.015 -9999 0 0 99 99
WNT11 0.036 0.006 -9999 0 0 14 14
Arf6 signaling events

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0.014 0.035 -10000 0 -0.11 38 38
ARNO/beta Arrestin1-2 0.042 0.025 -10000 0 -0.094 7 7
EGFR 0.009 0.016 -10000 0 0 381 381
EPHA2 0.033 0.011 -10000 0 0 54 54
USP6 0.035 0.007 -10000 0 0 18 18
IQSEC1 0.035 0.007 -10000 0 0 19 19
EGFR/EGFR/EGF/EGF -0.005 0.056 -10000 0 -0.14 64 64
ARRB2 0.012 0.025 -10000 0 -0.2 7 7
mol:GTP 0.002 0.012 -10000 0 -0.063 3 3
ARRB1 0.036 0.005 -10000 0 0 10 10
FBXO8 0 0 -10000 0 -10000 0 0
TSHR 0.033 0.011 -10000 0 0 48 48
EGF 0.035 0.008 -10000 0 0 25 25
somatostatin receptor activity 0 0 0.001 141 0 6 147
ARAP2 0 0 0 129 0 2 131
mol:GDP 0.068 0.068 0.16 125 -0.16 4 129
mol:PI-3-4-5-P3 0 0 0 132 0 5 137
ITGA2B 0.036 0.004 -10000 0 0 5 5
ARF6 0.035 0.008 -10000 0 0 27 27
Ephrin A1/EPHA2/NCK1/GIT1 0.076 0.052 -10000 0 -0.12 24 24
ADAP1 0 0 0 59 0 1 60
KIF13B 0.032 0.012 -10000 0 0 63 63
HGF/MET 0.032 0.027 -10000 0 -10000 0 0
PXN 0.036 0.004 -10000 0 0 7 7
ARF6/GTP 0.083 0.087 0.19 130 -0.2 5 135
EGFR/EGFR/EGF/EGF/ARFGEP100 0.001 0.055 -10000 0 -0.12 62 62
ADRB2 0.034 0.01 -10000 0 0 42 42
receptor agonist activity 0 0 0 141 0 5 146
actin filament binding 0 0 0 138 0 6 144
SRC 0.036 0.006 -10000 0 0 14 14
ITGB3 0.036 0.003 -10000 0 0 4 4
GNAQ 0.035 0.009 -10000 0 0 31 31
EFA6/PI-4-5-P2 0.001 0.001 0.001 164 -0.001 4 168
ARF6/GDP 0.036 0.063 0.16 15 -0.2 14 29
ARF6/GDP/GULP/ACAP1 0.055 0.075 0.2 19 -0.2 3 22
alphaIIb/beta3 Integrin/paxillin/GIT1 0.092 0.012 -10000 0 -10000 0 0
ACAP1 0 0 0 60 -10000 0 60
ACAP2 0 0 0 70 0 3 73
LHCGR/beta Arrestin2 0.03 0.024 -10000 0 -0.14 7 7
EFNA1 0.033 0.011 -10000 0 0 50 50
HGF 0.024 0.017 -10000 0 0 177 177
CYTH3 0 0 0.001 147 -0.001 4 151
CYTH2 0 0.001 0.003 1 -0.003 6 7
NCK1 0.035 0.008 -10000 0 0 27 27
fibronectin binding 0 0 0 141 0 5 146
endosomal lumen acidification 0 0 0 145 0 6 151
microtubule-based process 0 0 -10000 0 0 1 1
GULP1 0.024 0.017 -10000 0 0 168 168
GNAQ/ARNO 0.026 0.008 0.04 5 0 31 36
mol:Phosphatidic acid 0 0 0 70 0 3 73
PIP3-E 0.03 0.014 -10000 0 0 89 89
MET 0.023 0.018 -10000 0 0 191 191
GNA14 0.035 0.009 -10000 0 0 30 30
GNA15 0.033 0.012 -10000 0 0 57 57
GIT1 0.036 0.003 -10000 0 0 4 4
mol:PI-4-5-P2 0 0 0.001 146 -0.001 4 150
GNA11 0.033 0.011 -10000 0 0 54 54
LHCGR 0.037 0.003 -10000 0 0 3 3
AGTR1 0.035 0.008 -10000 0 0 22 22
desensitization of G-protein coupled receptor protein signaling pathway 0.03 0.024 -10000 0 -0.14 7 7
IPCEF1/ARNO 0.007 0.043 -10000 0 -0.09 51 51
alphaIIb/beta3 Integrin 0.054 0.006 -10000 0 -10000 0 0
Canonical Wnt signaling pathway

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.033 0.045 0.12 67 -0.039 84 151
AES 0.031 0.042 0.11 63 -0.036 80 143
FBXW11 0.035 0.008 -10000 0 0 25 25
mol:GTP 0 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.033 0.026 -10000 0 -10000 0 0
SMAD4 0.032 0.012 -10000 0 0 58 58
DKK2 0.034 0.009 -10000 0 0 31 31
TLE1 0.031 0.041 0.11 64 -0.036 84 148
MACF1 0.033 0.011 -10000 0 0 49 49
CTNNB1 0.045 0.11 0.26 20 -0.36 14 34
WIF1 0.028 0.015 -10000 0 0 112 112
beta catenin/RanBP3 0.071 0.16 0.42 62 -0.35 9 71
KREMEN2 0.036 0.004 -10000 0 0 7 7
DKK1 0.017 0.018 -10000 0 0 271 271
beta catenin/beta TrCP1 0.06 0.11 0.27 18 -0.36 13 31
FZD1 0.024 0.017 -10000 0 0 173 173
AXIN2 -0.024 0.093 0.12 3 -0.24 66 69
AXIN1 0.037 0.001 -10000 0 -10000 0 0
RAN 0.036 0.005 -10000 0 0 10 10
Axin1/APC/GSK3/beta catenin 0.015 0.16 -10000 0 -0.61 28 28
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.024 0.13 0.26 9 -0.44 18 27
Axin1/APC/GSK3 0.005 0.09 0.23 5 -0.39 16 21
Axin1/APC/GSK3/beta catenin/Macf1 0.032 0.14 0.26 12 -0.39 28 40
HNF1A 0.006 0.03 0.071 73 -0.038 3 76
CTBP1 0.031 0.041 0.11 61 -0.037 83 144
MYC -0.097 0.4 0.74 14 -1.3 49 63
RANBP3 0.035 0.008 -10000 0 0 23 23
DKK2/LRP6/Kremen 2 0.064 0.027 -10000 0 -0.12 1 1
NKD1 0 0.001 -10000 0 -10000 0 0
TCF4 0.03 0.038 0.11 59 -0.036 68 127
TCF3 0.032 0.042 0.11 64 -0.036 83 147
WNT1/LRP6/FZD1/Axin1 0.059 0.046 -10000 0 -10000 0 0
Ran/GTP 0.026 0.016 -10000 0 -0.13 5 5
CtBP/CBP/TCF/TLE1/AES 0.035 0.19 0.46 65 -0.34 20 85
LEF1 0.033 0.044 0.11 71 -0.037 86 157
DVL1 0.01 0.098 -10000 0 -0.42 18 18
CSNK2A1 0.035 0.009 -10000 0 0 31 31
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.01 0.16 0.26 8 -0.5 30 38
DKK1/LRP6/Kremen 2 0.031 0.037 -10000 0 -10000 0 0
LRP6 0.034 0.01 -10000 0 0 40 40
CSNK1A1 0.034 0.046 0.12 68 -0.038 86 154
NLK 0.026 0.023 -10000 0 -0.032 56 56
CCND1 -0.08 0.35 0.79 3 -1.3 38 41
WNT1 0.036 0.007 -10000 0 0 16 16
GSK3A 0.035 0.009 -10000 0 0 28 28
GSK3B 0.034 0.01 -10000 0 0 40 40
FRAT1 0.025 0.017 -10000 0 0 161 161
PPP2R5D 0.023 0.044 -10000 0 -0.24 8 8
APC 0.04 0.1 0.18 161 -10000 0 161
WNT1/LRP6/FZD1 0.001 0.049 -10000 0 -0.26 11 11
CREBBP 0.033 0.043 0.11 68 -0.036 86 154
S1P5 pathway

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.006 0.1 0.19 87 -10000 0 87
GNAI2 0.034 0.01 -10000 0 0 43 43
S1P/S1P5/G12 0.009 0.03 -10000 0 -0.11 28 28
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 0.03 0.014 -10000 0 0 87 87
RhoA/GTP 0.007 0.11 -10000 0 -0.2 87 87
negative regulation of cAMP metabolic process -0.007 0.099 -10000 0 -0.21 80 80
GNAZ 0.031 0.013 -10000 0 0 81 81
GNAI3 0.036 0.006 -10000 0 0 15 15
GNA12 0.023 0.018 -10000 0 0 193 193
S1PR5 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi -0.007 0.1 -10000 0 -0.21 80 80
RhoA/GDP 0.024 0.019 -10000 0 -0.13 7 7
RHOA 0.035 0.007 -10000 0 0 18 18
GNAI1 0.018 0.018 -10000 0 0 263 263
S1P4 pathway

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
GNAO1 0.03 0.014 -10000 0 0 87 87
CDC42/GTP 0.007 0.1 -10000 0 -0.19 84 84
PLCG1 -0.011 0.097 0.12 5 -0.2 83 88
mol:GTP 0 0 -10000 0 -10000 0 0
GNAI2 0.034 0.01 -10000 0 0 43 43
GNAI3 0.036 0.006 -10000 0 0 15 15
G12/G13 0.025 0.047 -10000 0 -0.14 28 28
cell migration 0.006 0.1 -10000 0 -0.19 84 84
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
MAPK3 -0.012 0.098 0.12 4 -0.2 85 89
MAPK1 -0.006 0.094 0.12 5 -0.2 77 82
S1P/S1P5/Gi -0.007 0.1 -10000 0 -0.21 80 80
GNAI1 0.018 0.018 -10000 0 0 263 263
CDC42/GDP 0.026 0.006 -10000 0 -10000 0 0
S1P/S1P5/G12 0.009 0.03 -10000 0 -0.11 28 28
RHOA 0.043 0.1 0.19 161 -0.18 3 164
S1P/S1P4/Gi -0.007 0.1 -10000 0 -0.21 80 80
mol:GDP 0 0 -10000 0 -10000 0 0
GNAZ 0.031 0.013 -10000 0 0 81 81
S1P/S1P4/G12/G13 0.023 0.037 -10000 0 -0.1 28 28
GNA12 0.023 0.018 -10000 0 0 193 193
GNA13 0.035 0.007 -10000 0 0 19 19
CDC42 0.035 0.008 -10000 0 0 24 24
TCGA08_retinoblastoma

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B 0.003 0.026 -10000 0 -0.053 54 54
CDKN2C -0.009 0.021 -10000 0 -0.035 122 122
CDKN2A 0.005 0.015 -10000 0 -0.043 1 1
CCND2 -0.001 0.018 0.11 6 -10000 0 6
RB1 -0.045 0.09 0.16 2 -0.18 139 141
CDK4 -0.001 0.02 0.13 6 -10000 0 6
CDK6 -0.001 0.02 0.13 6 -10000 0 6
G1/S progression 0.053 0.095 0.19 155 -0.16 2 157
Ras signaling in the CD4+ TCR pathway

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 0.024 0.14 -10000 0 -0.33 30 30
MAP3K8 0.022 0.018 -10000 0 0 197 197
FOS 0.019 0.1 -10000 0 -0.34 16 16
PRKCA 0.029 0.025 -10000 0 -0.03 76 76
PTPN7 0.028 0.029 0.066 53 -0.037 72 125
HRAS 0.034 0.009 -10000 0 0 32 32
PRKCB 0 0.008 0.016 61 -0.013 77 138
NRAS 0.032 0.012 -10000 0 0 63 63
RAS family/GTP 0.042 0.065 -10000 0 -0.13 53 53
MAPK3 0.035 0.052 -10000 0 -0.31 3 3
MAP2K1 0.012 0.055 -10000 0 -0.22 12 12
ELK1 0.026 0.029 -10000 0 -0.04 79 79
BRAF 0.007 0.021 -10000 0 -10000 0 0
mol:GTP 0 0.002 0.002 61 -0.004 77 138
MAPK1 0.008 0.13 -10000 0 -0.44 31 31
RAF1 -0.001 0.067 -10000 0 -0.34 17 17
KRAS 0.034 0.009 -10000 0 0 35 35
LPA receptor mediated events

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.006 0.057 -10000 0 -0.14 60 60
NF kappa B1 p50/RelA/I kappa B alpha 0.007 0.096 0.21 11 -0.2 47 58
AP1 -0.009 0.073 0.088 17 -0.14 90 107
mol:PIP3 -0.024 0.05 -10000 0 -0.13 76 76
AKT1 0.002 0.094 0.2 22 -0.25 26 48
PTK2B -0.002 0.058 0.12 6 -0.15 57 63
RHOA 0.022 0.078 0.18 17 -0.34 11 28
PIK3CB 0.035 0.007 -10000 0 0 18 18
mol:Ca2+ -0.009 0.04 0.19 5 -0.14 19 24
MAGI3 0 0 -10000 0 -0.002 1 1
RELA 0.036 0.005 -10000 0 0 9 9
apoptosis 0.002 0.062 0.1 36 -0.16 53 89
HRAS/GDP 0.021 0.027 -10000 0 -0.13 15 15
positive regulation of microtubule depolymerization -0.02 0.074 0.17 11 -0.19 48 59
NF kappa B1 p50/RelA -0.021 0.066 0.078 64 -0.17 53 117
endothelial cell migration -0.017 0.097 -10000 0 -0.3 53 53
ADCY4 -0.004 0.091 0.14 13 -0.24 41 54
ADCY5 -0.004 0.091 0.14 13 -0.24 41 54
ADCY6 0.001 0.092 0.16 15 -0.25 37 52
ADCY7 -0.002 0.096 0.15 17 -0.25 42 59
ADCY1 -0.009 0.083 0.15 9 -0.26 34 43
ADCY2 -0.001 0.094 0.16 14 -0.23 44 58
ADCY3 -0.004 0.091 0.14 13 -0.24 41 54
ADCY8 -0.002 0.091 0.15 17 -0.24 39 56
ADCY9 0 0.091 0.16 15 -0.24 39 54
GSK3B -0.009 0.065 0.18 8 -0.16 56 64
arachidonic acid secretion -0.016 0.11 0.15 14 -0.24 66 80
GNG2 0 0.001 0.002 2 -0.003 15 17
TRIP6 -0.016 0.085 -10000 0 -0.25 57 57
GNAO1 0.003 0.057 0.12 24 -0.16 47 71
HRAS 0.034 0.009 -10000 0 0 32 32
NFKBIA -0.017 0.083 0.17 15 -0.2 45 60
GAB1 0.032 0.012 -10000 0 0 59 59
mol:GTP 0 0 -10000 0 -10000 0 0
lamellipodium assembly -0.009 0.21 -10000 0 -0.8 31 31
JUN 0.034 0.01 -10000 0 0 40 40
LPA/LPA2/NHERF2 0.019 0.029 -10000 0 -0.061 53 53
TIAM1 -0.015 0.25 -10000 0 -0.98 31 31
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 -0.008 0.039 0.22 3 -0.14 19 22
PLCB3 0.006 0.035 0.2 5 -10000 0 5
FOS 0.025 0.017 -10000 0 0 158 158
positive regulation of mitosis -0.016 0.11 0.15 14 -0.24 66 80
LPA/LPA1-2-3 -0.008 0.04 -10000 0 -0.12 53 53
mol:Ca ++ 0 0 -10000 0 -10000 0 0
JNK cascade 0 0.001 -10000 0 -0.002 1 1
BCAR1 0 0 -10000 0 -10000 0 0
stress fiber formation 0.009 0.066 -10000 0 -0.28 9 9
GNAZ 0.003 0.063 0.12 28 -0.17 48 76
EGFR/PI3K-beta/Gab1 -0.02 0.054 -10000 0 -0.13 77 77
positive regulation of dendritic cell cytokine production -0.008 0.04 -10000 0 -0.12 53 53
LPA/LPA2/MAGI-3 -0.004 0.017 -10000 0 -0.052 53 53
ARHGEF1 0.039 0.12 0.2 147 -0.17 34 181
GNAI2 0.004 0.069 0.12 40 -0.17 53 93
GNAI3 0.007 0.063 0.12 39 -0.15 53 92
GNAI1 0.002 0.047 0.12 19 -0.16 29 48
LPA/LPA3 -0.006 0.021 -10000 0 -0.066 53 53
LPA/LPA2 -0.005 0.021 -10000 0 -0.065 53 53
LPA/LPA1 -0.012 0.054 -10000 0 -0.17 53 53
HB-EGF/EGFR -0.01 0.056 -10000 0 -0.14 66 66
HBEGF 0.011 0.046 0.092 116 -10000 0 116
mol:DAG -0.008 0.039 0.22 3 -0.14 19 22
cAMP biosynthetic process 0.003 0.11 0.18 33 -0.26 43 76
NFKB1 0.035 0.007 -10000 0 0 18 18
SRC 0.036 0.006 -10000 0 0 14 14
GNB1 0.035 0.007 -10000 0 0 20 20
LYN -0.023 0.095 0.17 17 -0.23 62 79
GNAQ 0.008 0.026 0.056 38 -0.058 55 93
LPAR2 0 0.001 0.002 1 -0.002 7 8
LPAR3 0 0.001 -10000 0 -0.002 20 20
LPAR1 -0.009 0.033 -10000 0 -0.1 53 53
IL8 -0.13 0.2 0.32 8 -0.39 157 165
PTK2 0.014 0.057 0.12 39 -0.14 50 89
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
CASP3 0.002 0.062 0.1 36 -0.16 53 89
EGFR 0.009 0.016 -10000 0 0 381 381
PLCG1 0.005 0.038 0.072 8 -0.099 39 47
PLD2 0.015 0.053 0.12 38 -0.12 52 90
G12/G13 0.018 0.062 -10000 0 -0.15 45 45
PI3K-beta -0.014 0.069 -10000 0 -0.26 23 23
cell migration -0.002 0.073 -10000 0 -0.24 31 31
SLC9A3R2 0.036 0.005 -10000 0 0 9 9
PXN 0.009 0.067 -10000 0 -0.29 9 9
HRAS/GTP -0.018 0.11 0.16 8 -0.25 66 74
RAC1 0.024 0.017 -10000 0 0 173 173
MMP9 0.017 0.018 -10000 0 0 267 267
PRKCE 0.036 0.003 -10000 0 0 4 4
PRKCD -0.005 0.054 0.18 14 -0.2 3 17
Gi(beta/gamma) -0.009 0.12 0.14 21 -0.26 60 81
mol:LPA -0.009 0.033 -10000 0 -0.1 53 53
TRIP6/p130 Cas/FAK1/Paxillin -0.008 0.081 -10000 0 -0.22 42 42
MAPKKK cascade -0.016 0.11 0.15 14 -0.24 66 80
contractile ring contraction involved in cytokinesis 0.021 0.08 0.18 17 -0.34 12 29
mol:GDP 0 0 -10000 0 -10000 0 0
GNA14 0.008 0.026 0.056 37 -0.058 55 92
GNA15 0.008 0.025 0.056 33 -0.057 51 84
GNA12 0.023 0.018 -10000 0 0 193 193
GNA13 0.035 0.007 -10000 0 0 19 19
MAPT -0.02 0.075 0.17 11 -0.18 58 69
GNA11 0.011 0.022 0.056 37 -0.057 34 71
Rac1/GTP -0.01 0.22 -10000 0 -0.85 31 31
MMP2 -0.017 0.097 -10000 0 -0.3 53 53
EPO signaling pathway

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.047 0.082 0.3 4 -10000 0 4
CRKL 0.043 0.09 0.16 174 -10000 0 174
mol:DAG 0.016 0.063 0.21 2 -0.19 28 30
HRAS 0.043 0.1 0.23 61 -0.19 2 63
MAPK8 0.012 0.076 0.16 82 -10000 0 82
RAP1A 0.049 0.093 0.16 187 -10000 0 187
GAB1 0.04 0.087 0.16 161 -10000 0 161
MAPK14 0.034 0.1 0.17 152 -10000 0 152
EPO 0.027 0.02 -10000 0 -0.032 2 2
PLCG1 0.016 0.063 0.21 2 -0.19 28 30
EPOR/TRPC2/IP3 Receptors 0.041 0.013 -10000 0 -0.032 2 2
RAPGEF1 0.035 0.007 -10000 0 0 19 19
EPO/EPOR (dimer)/SOCS3 0.051 0.038 -10000 0 -10000 0 0
GAB1/SHC/GRB2/SOS1 0.06 0.072 0.21 28 -0.11 1 29
EPO/EPOR (dimer) 0.039 0.03 -10000 0 -10000 0 0
IRS2 0.038 0.088 0.16 153 -0.16 4 157
STAT1 0.02 0.066 0.22 6 -0.19 28 34
STAT5B 0.019 0.066 0.21 5 -0.19 29 34
cell proliferation 0.008 0.075 0.16 83 -10000 0 83
GAB1/SHIP/PIK3R1/SHP2/SHC 0.037 0.064 0.16 3 -0.17 7 10
TEC 0.049 0.093 0.16 188 -10000 0 188
SOCS3 0.036 0.004 -10000 0 0 7 7
STAT1 (dimer) 0.02 0.065 0.22 6 -0.18 28 34
JAK2 0.037 0.018 0.076 2 -10000 0 2
PIK3R1 0.032 0.012 -10000 0 0 63 63
EPO/EPOR (dimer)/JAK2 0.047 0.053 0.22 11 -0.091 2 13
EPO/EPOR 0.039 0.03 -10000 0 -10000 0 0
LYN 0.032 0.014 -10000 0 -10000 0 0
TEC/VAV2 0.036 0.085 0.16 149 -10000 0 149
elevation of cytosolic calcium ion concentration 0.041 0.013 -10000 0 -0.032 2 2
SHC1 0.033 0.011 -10000 0 0 52 52
EPO/EPOR (dimer)/LYN 0.04 0.059 -10000 0 -0.13 29 29
mol:IP3 0.016 0.063 0.21 2 -0.19 28 30
PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.023 0.093 0.16 135 -0.17 11 146
SH2B3 -0.001 0.006 0.022 19 -10000 0 19
NFKB1 0.034 0.1 0.17 149 -0.2 1 150
EPO/EPOR (dimer)/JAK2/SOCS3 0.015 0.015 -10000 0 -10000 0 0
PTPN6 0.049 0.094 0.17 167 -10000 0 167
TEC/VAV2/GRB2 0.082 0.071 0.23 34 -10000 0 34
EPOR 0.041 0.013 -10000 0 -0.032 2 2
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.06 0.072 0.21 28 -0.11 1 29
SOS1 0 0 -10000 0 -10000 0 0
PLCG2 0.032 0.012 -10000 0 0 63 63
CRKL/CBL/C3G 0.08 0.067 0.22 29 -10000 0 29
VAV2 0.047 0.091 0.16 182 -10000 0 182
CBL 0.049 0.093 0.16 187 -10000 0 187
SHC/Grb2/SOS1 0.021 0.035 -10000 0 -0.1 12 12
STAT5A 0.019 0.065 0.25 2 -0.19 28 30
GRB2 0.035 0.007 -10000 0 0 17 17
STAT5 (dimer) 0.034 0.073 0.27 5 -0.2 8 13
LYN/PLCgamma2 0.026 0.07 -10000 0 -0.17 53 53
PTPN11 0.036 0.005 -10000 0 0 11 11
BTK 0.046 0.093 0.16 185 -10000 0 185
BCL2 0.047 0.082 0.31 1 -10000 0 1
Syndecan-1-mediated signaling events

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.032 0.012 -10000 0 0 66 66
CCL5 0.033 0.011 -10000 0 0 53 53
SDCBP 0.035 0.007 -10000 0 0 21 21
FGFR/FGF2/Syndecan-1 0.014 0.1 0.21 24 -0.24 10 34
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
Syndecan-1/Laminin-5 0.02 0.1 0.22 19 -0.25 11 30
Syndecan-1/Syntenin 0.025 0.11 0.22 28 -0.24 14 42
MAPK3 0.003 0.1 0.19 23 -0.23 18 41
HGF/MET 0.032 0.027 -10000 0 -10000 0 0
TGFB1/TGF beta receptor Type II 0.032 0.012 -10000 0 0 66 66
BSG 0.032 0.012 -10000 0 0 66 66
keratinocyte migration 0.02 0.1 0.22 19 -0.24 11 30
Syndecan-1/RANTES 0.019 0.1 0.23 18 -0.25 10 28
Syndecan-1/CD147 0.023 0.11 0.23 15 -0.24 18 33
Syndecan-1/Syntenin/PIP2 0.022 0.1 0.21 25 -0.23 14 39
LAMA5 0.032 0.012 -10000 0 0 65 65
positive regulation of cell-cell adhesion 0.022 0.1 0.21 25 -0.23 14 39
MMP7 0.027 0.016 -10000 0 0 137 137
HGF 0.024 0.017 -10000 0 0 177 177
Syndecan-1/CASK -0.001 0.085 0.15 5 -0.23 11 16
Syndecan-1/HGF/MET 0.024 0.089 0.24 10 -0.25 5 15
regulation of cell adhesion -0.004 0.11 0.22 32 -0.23 20 52
HPSE 0.032 0.012 -10000 0 0 59 59
positive regulation of cell migration 0.014 0.1 0.21 24 -0.24 10 34
SDC1 0.01 0.095 0.17 36 -0.25 9 45
Syndecan-1/Collagen 0.014 0.1 0.21 24 -0.24 10 34
PPIB 0.034 0.01 -10000 0 0 39 39
MET 0.023 0.018 -10000 0 0 191 191
PRKACA 0.035 0.008 -10000 0 0 25 25
MMP9 0.017 0.018 -10000 0 0 267 267
MAPK1 0.003 0.098 0.19 22 -0.24 18 40
homophilic cell adhesion 0.016 0.1 0.21 29 -0.24 10 39
MMP1 0.031 0.013 -10000 0 0 71 71
Nongenotropic Androgen signaling

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.011 0.003 0 32 -0.017 1 33
GNB1/GNG2 0.039 0.03 -10000 0 -0.1 20 20
regulation of S phase of mitotic cell cycle -0.004 0.081 -10000 0 -0.19 71 71
GNAO1 0.03 0.014 -10000 0 0 87 87
HRAS 0.034 0.009 -10000 0 0 32 32
SHBG/T-DHT 0.024 0.004 -10000 0 -10000 0 0
PELP1 0.035 0.007 -10000 0 0 17 17
AKT1 -0.01 0.004 0 53 -10000 0 53
MAP2K1 -0.035 0.076 0.18 16 -0.18 71 87
T-DHT/AR 0.025 0.008 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP -0.001 0.003 0.003 30 -0.006 76 106
GNAI2 0.033 0.01 -10000 0 0 43 43
GNAI3 0.036 0.006 -10000 0 0 15 15
GNAI1 0.018 0.018 -10000 0 0 263 263
mol:GDP -0.02 0.036 -10000 0 -0.14 15 15
cell proliferation -0.059 0.18 0.27 11 -0.42 85 96
PIK3CA 0.031 0.013 -10000 0 0 80 80
FOS -0.087 0.28 0.38 3 -0.69 83 86
mol:Ca2+ -0.004 0.02 0.028 5 -0.054 57 62
MAPK3 -0.043 0.13 0.25 14 -0.3 78 92
MAPK1 -0.04 0.16 0.25 3 -0.49 37 40
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 0 0.002 0.003 59 -0.004 74 133
cAMP biosynthetic process -0.002 0.013 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
potassium channel inhibitor activity 0 0.002 0.003 59 -0.004 74 133
HRAS/GTP 0.043 0.065 -10000 0 -0.094 75 75
actin cytoskeleton reorganization 0.019 0.054 -10000 0 -0.12 45 45
SRC 0.035 0.006 -10000 0 0 14 14
voltage-gated calcium channel activity 0 0.002 0.003 59 -0.004 74 133
PI3K 0.019 0.063 -10000 0 -0.13 73 73
apoptosis 0.048 0.19 0.43 84 -0.26 8 92
T-DHT/AR/PELP1 0.043 0.023 -10000 0 -0.1 9 9
HRAS/GDP 0.007 0.06 -10000 0 -0.18 14 14
CREB1 -0.068 0.19 0.27 8 -0.46 84 92
RAC1-CDC42/GTP 0.027 0.06 -10000 0 -0.12 45 45
AR 0.035 0.008 -10000 0 0 22 22
GNB1 0.035 0.007 -10000 0 0 20 20
RAF1 -0.026 0.068 0.19 15 -0.22 13 28
RAC1-CDC42/GDP 0.02 0.053 -10000 0 -0.19 8 8
T-DHT/AR/PELP1/Src 0.06 0.032 -10000 0 -0.086 13 13
MAP2K2 -0.038 0.069 0.16 8 -0.17 68 76
T-DHT/AR/PELP1/Src/PI3K -0.004 0.081 -10000 0 -0.19 71 71
GNAZ 0.031 0.013 -10000 0 0 81 81
SHBG 0.036 0.006 -10000 0 0 14 14
Gi family/GNB1/GNG2/GDP -0.038 0.17 -10000 0 -0.45 52 52
mol:T-DHT 0 0.001 0.002 1 -0.004 21 22
RAC1 0.024 0.017 -10000 0 0 173 173
GNRH1 -0.011 0.002 0 12 -10000 0 12
Gi family/GTP -0.005 0.082 -10000 0 -0.19 62 62
CDC42 0.035 0.008 -10000 0 0 24 24
Syndecan-2-mediated signaling events

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.014 0.061 0.14 1 -0.13 69 70
EPHB2 0.034 0.01 -10000 0 0 42 42
Syndecan-2/TACI 0.017 0.055 0.14 1 -0.12 66 67
LAMA1 0 0 -10000 0 -10000 0 0
Syndecan-2/alpha2 ITGB1 0.022 0.073 -10000 0 -0.12 83 83
HRAS 0.034 0.009 -10000 0 0 32 32
Syndecan-2/CASK -0.009 0.041 0.062 3 -0.11 69 72
ITGA5 0.033 0.011 -10000 0 0 56 56
BAX -0.009 0.073 -10000 0 -0.9 3 3
EPB41 0.036 0.005 -10000 0 0 9 9
positive regulation of cell-cell adhesion 0.013 0.054 -10000 0 -0.11 73 73
LAMA3 0.033 0.011 -10000 0 0 48 48
EZR 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 0.019 0.018 -10000 0 0 246 246
Syndecan-2/MMP2 0.009 0.062 0.14 1 -0.14 65 66
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 0.019 0.054 -10000 0 -0.14 42 42
dendrite morphogenesis 0.015 0.054 0.14 1 -0.12 62 63
Syndecan-2/GM-CSF 0.017 0.055 0.14 1 -0.12 64 65
determination of left/right symmetry 0.007 0.024 0.085 5 -0.24 4 9
Syndecan-2/PKC delta 0.016 0.054 0.14 1 -0.12 62 63
GNB2L1 0.036 0.002 -10000 0 0 2 2
MAPK3 -0.023 0.051 0.11 36 -0.11 64 100
MAPK1 -0.02 0.05 0.12 31 -0.12 52 83
Syndecan-2/RACK1 0.03 0.063 0.14 3 -0.11 77 80
NF1 0.036 0.003 -10000 0 0 4 4
FGFR/FGF/Syndecan-2 0.007 0.024 0.085 5 -0.24 4 9
ITGA2 0.029 0.015 -10000 0 0 112 112
MAPK8 -0.005 0.038 0.13 3 -0.39 3 6
Syndecan-2/alpha2/beta1 Integrin 0.007 0.063 0.14 1 -0.11 92 93
Syndecan-2/Kininogen 0.016 0.054 0.14 1 -0.12 63 64
ITGB1 0.027 0.016 -10000 0 0 138 138
SRC -0.026 0.051 0.17 11 -0.19 8 19
Syndecan-2/CASK/Protein 4.1 0.015 0.05 -10000 0 -0.1 68 68
extracellular matrix organization 0.014 0.051 -10000 0 -0.12 57 57
actin cytoskeleton reorganization 0.014 0.061 0.14 1 -0.13 69 70
Syndecan-2/Caveolin-2/Ras 0.007 0.067 0.15 2 -0.13 75 77
Syndecan-2/Laminin alpha3 0.016 0.052 0.14 1 -0.12 60 61
Syndecan-2/RasGAP 0.037 0.078 -10000 0 -0.12 89 89
alpha5/beta1 Integrin 0.029 0.042 -10000 0 -0.14 20 20
PRKCD 0.034 0.01 -10000 0 0 40 40
Syndecan-2 dimer 0.015 0.054 0.14 1 -0.12 62 63
GO:0007205 0.001 0.011 -10000 0 -0.12 4 4
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.014 0.067 0.19 1 -0.12 79 80
RHOA 0.035 0.007 -10000 0 0 18 18
SDCBP 0.035 0.007 -10000 0 0 21 21
TNFRSF13B 0.036 0.005 -10000 0 0 8 8
RASA1 0.034 0.009 -10000 0 0 32 32
alpha2/beta1 Integrin 0.019 0.054 -10000 0 -0.14 42 42
Syndecan-2/Synbindin 0.016 0.059 0.14 1 -0.13 67 68
TGFB1 0.032 0.012 -10000 0 0 66 66
CASP3 -0.016 0.052 0.11 32 -0.2 4 36
FN1 0.035 0.009 -10000 0 0 29 29
Syndecan-2/IL8 -0.003 0.069 -10000 0 -0.17 61 61
SDC2 0.007 0.024 0.085 5 -0.24 4 9
KNG1 0.035 0.008 -10000 0 0 28 28
Syndecan-2/Neurofibromin 0.017 0.056 0.14 1 -0.12 68 69
TRAPPC4 0.036 0.006 -10000 0 0 15 15
CSF2 0.036 0.005 -10000 0 0 10 10
Syndecan-2/TGFB1 0.015 0.051 -10000 0 -0.12 57 57
Syndecan-2/Syntenin/PI-4-5-P2 0.013 0.055 -10000 0 -0.11 73 73
Syndecan-2/Ezrin 0.014 0.053 -10000 0 -0.11 70 70
PRKACA -0.021 0.051 0.12 35 -0.11 63 98
angiogenesis -0.003 0.068 -10000 0 -0.17 61 61
MMP2 0.029 0.015 -10000 0 0 108 108
IL8 0.019 0.018 -10000 0 0 243 243
calcineurin-NFAT signaling pathway 0.017 0.055 0.14 1 -0.12 66 67
IL2 signaling events mediated by STAT5

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.032 0.014 -10000 0 -0.005 56 56
ELF1 0.042 0.016 -10000 0 -10000 0 0
CCNA2 0.028 0.015 -10000 0 0 117 117
PIK3CA 0.03 0.015 -10000 0 -0.002 87 87
JAK3 0.034 0.012 -10000 0 -0.009 31 31
PIK3R1 0.032 0.014 -10000 0 -0.002 68 68
JAK1 0.033 0.012 -10000 0 -0.003 46 46
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.02 0.18 0.24 2 -0.53 39 41
SHC1 0.032 0.014 -10000 0 -0.004 60 60
SP1 -0.011 0.12 -10000 0 -0.27 89 89
IL2RA 0.011 0.012 -10000 0 -10000 0 0
IL2RB 0.032 0.014 -10000 0 -0.004 61 61
SOS1 0 0.002 -10000 0 -10000 0 0
IL2RG 0.034 0.011 -10000 0 -0.006 30 30
G1/S transition of mitotic cell cycle -0.069 0.27 0.28 7 -0.59 92 99
PTPN11 0.035 0.01 -10000 0 -0.03 7 7
CCND2 -0.074 0.19 -10000 0 -0.49 89 89
LCK 0.035 0.01 -10000 0 -0.009 24 24
GRB2 0.035 0.01 -10000 0 -0.009 24 24
IL2 0.035 0.009 -10000 0 -0.012 17 17
CDK6 0.024 0.017 -10000 0 0 176 176
CCND3 -0.026 0.2 0.36 3 -0.74 27 30
Fc-epsilon receptor I signaling in mast cells

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.032 0.012 -10000 0 0 63 63
LAT2 -0.016 0.094 0.16 1 -0.28 46 47
AP1 -0.058 0.18 -10000 0 -0.39 68 68
mol:PIP3 0.021 0.14 0.26 38 -0.28 46 84
IKBKB 0.011 0.094 0.2 36 -0.19 38 74
AKT1 -0.055 0.1 0.25 10 -0.27 41 51
IKBKG 0.01 0.093 0.19 36 -0.19 38 74
MS4A2 0.039 0.008 0.066 4 0 5 9
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.031 0.013 -10000 0 0 80 80
MAP3K1 -0.023 0.12 0.23 9 -0.3 52 61
mol:Ca2+ 0.023 0.12 0.23 40 -0.23 36 76
LYN 0.03 0.015 -10000 0 -0.034 6 6
CBLB -0.023 0.11 0.16 2 -0.28 66 68
SHC1 0.033 0.011 -10000 0 0 52 52
RasGAP/p62DOK 0.048 0.052 -10000 0 -0.12 36 36
positive regulation of cell migration -0.011 0.003 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
PLD2 -0.032 0.071 0.26 14 -0.17 11 25
PTPN13 -0.036 0.19 -10000 0 -0.6 38 38
PTPN11 0.031 0.022 -10000 0 -0.035 47 47
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation -0.036 0.11 0.23 8 -0.32 36 44
SYK 0.03 0.015 -10000 0 -0.034 6 6
GRB2 0.036 0.007 -10000 0 0 17 17
LAT/PLCgamma1/GRB2/SLP76/GADs 0.009 0.11 0.2 4 -0.27 55 59
LAT -0.021 0.11 0.18 3 -0.28 65 68
PAK2 -0.022 0.13 0.22 7 -0.33 52 59
NFATC2 -0.013 0.013 -10000 0 -0.043 69 69
HRAS -0.02 0.14 0.2 10 -0.35 52 62
GAB2 0.033 0.011 -10000 0 0 47 47
PLA2G1B -0.005 0.19 -10000 0 -0.92 20 20
Fc epsilon R1 0.042 0.067 -10000 0 -0.11 73 73
Antigen/IgE/Fc epsilon R1 0.044 0.06 -10000 0 -0.093 72 72
mol:GDP -0.013 0.14 0.21 12 -0.36 49 61
JUN 0.034 0.01 -10000 0 0 40 40
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 0.032 0.012 -10000 0 0 63 63
FOS 0.025 0.017 -10000 0 0 158 158
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.015 0.12 -10000 0 -0.29 68 68
CHUK 0.012 0.091 0.19 39 -0.18 39 78
KLRG1 -0.018 0.099 0.14 3 -0.27 49 52
VAV1 -0.021 0.11 0.16 4 -0.28 59 63
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.024 0.11 0.16 2 -0.28 68 70
negative regulation of mast cell degranulation -0.021 0.092 0.12 1 -0.25 51 52
BTK -0.012 0.13 -10000 0 -0.37 46 46
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.027 0.11 -10000 0 -0.19 130 130
GAB2/PI3K/SHP2 -0.068 0.073 -10000 0 -0.21 71 71
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.003 0.072 -10000 0 -0.19 57 57
RAF1 -0.007 0.2 -10000 0 -0.97 20 20
Fc epsilon R1/FcgammaRIIB/SHIP 0.024 0.095 -10000 0 -0.13 129 129
FCER1G 0.029 0.016 -10000 0 0 113 113
FCER1A 0.033 0.013 -10000 0 -0.007 42 42
Antigen/IgE/Fc epsilon R1/Fyn 0.041 0.082 -10000 0 -0.11 99 99
MAPK3 -0.004 0.19 -10000 0 -0.9 20 20
MAPK1 -0.013 0.2 -10000 0 -0.95 20 20
NFKB1 0.035 0.007 -10000 0 0 18 18
MAPK8 -0.12 0.28 -10000 0 -0.56 143 143
DUSP1 0.031 0.013 -10000 0 0 77 77
NF-kappa-B/RelA 0.018 0.066 0.14 30 -0.13 36 66
actin cytoskeleton reorganization -0.027 0.19 -10000 0 -0.6 36 36
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K -0.01 0.15 0.23 9 -0.35 54 63
FER -0.022 0.12 0.16 3 -0.28 68 71
RELA 0.036 0.005 -10000 0 0 9 9
ITK 0.001 0.04 -10000 0 -0.2 7 7
SOS1 0 0 -10000 0 -10000 0 0
PLCG1 -0.007 0.14 0.22 16 -0.33 50 66
cytokine secretion 0.01 0.045 0.088 26 -0.093 38 64
SPHK1 -0.02 0.12 0.15 4 -0.28 66 70
PTK2 -0.03 0.2 -10000 0 -0.64 36 36
NTAL/PLCgamma1/GRB2/SLP76/GADs 0.025 0.12 0.24 5 -0.28 48 53
EDG1 -0.011 0.003 -10000 0 -10000 0 0
mol:DAG 0.003 0.15 0.25 34 -0.32 47 81
MAP2K2 -0.005 0.2 -10000 0 -0.92 20 20
MAP2K1 -0.017 0.19 -10000 0 -0.92 20 20
MAP2K7 0.035 0.008 -10000 0 0 24 24
KLRG1/SHP2 0.001 0.097 0.2 8 -0.25 46 54
MAP2K4 0.025 0.14 -10000 0 -0.9 11 11
Fc epsilon R1/FcgammaRIIB 0.026 0.1 -10000 0 -0.14 129 129
mol:Choline -0.031 0.07 0.26 14 -0.17 11 25
SHC/Grb2/SOS1 0.011 0.13 -10000 0 -0.27 67 67
FYN 0.03 0.014 -10000 0 0 90 90
DOK1 0.036 0.002 -10000 0 0 2 2
PXN -0.03 0.19 -10000 0 -0.59 36 36
HCLS1 -0.025 0.13 0.16 6 -0.32 65 71
PRKCB 0.013 0.12 0.22 39 -0.23 50 89
FCGR2B 0.021 0.018 -10000 0 0 222 222
IGHE -0.001 0.004 0.021 3 -10000 0 3
KLRG1/SHIP -0.022 0.094 0.12 1 -0.26 51 52
LCP2 0.031 0.013 -10000 0 0 77 77
PLA2G4A -0.016 0.12 0.16 10 -0.3 59 69
RASA1 0.034 0.009 -10000 0 0 32 32
mol:Phosphatidic acid -0.031 0.07 0.26 14 -0.17 11 25
IKK complex 0.008 0.079 0.18 31 -0.16 24 55
WIPF1 0 0 -10000 0 -10000 0 0
amb2 Integrin signaling

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 0.029 0.085 -10000 0 -0.14 87 87
alphaM/beta2 Integrin/GPIbA 0.049 0.069 -10000 0 -0.12 58 58
alphaM/beta2 Integrin/proMMP-9 -0.008 0.09 -10000 0 -0.13 143 143
PLAUR 0.03 0.014 -10000 0 0 89 89
HMGB1 0.038 0.015 0.082 1 -10000 0 1
alphaM/beta2 Integrin/Talin 0.038 0.071 -10000 0 -0.13 56 56
AGER 0.041 0.01 0.08 2 -10000 0 2
RAP1A 0.036 0.005 -10000 0 0 11 11
SELPLG 0.036 0.004 -10000 0 0 6 6
mol:LDL 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 0.074 0.084 -10000 0 -0.16 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
MMP9 0.017 0.018 -10000 0 0 267 267
CYR61 0.025 0.017 -10000 0 0 166 166
TLN1 0.029 0.015 -10000 0 0 102 102
Rap1/GTP 0.028 0.072 -10000 0 -0.22 17 17
RHOA 0.035 0.007 -10000 0 0 18 18
P-selectin oligomer 0.036 0.006 -10000 0 0 14 14
MYH2 0.025 0.071 0.19 2 -0.28 8 10
MST1R 0.035 0.007 -10000 0 0 21 21
leukocyte activation during inflammatory response 0.056 0.064 -10000 0 -0.1 54 54
APOB 0.036 0.006 -10000 0 0 14 14
mol:GDP 0 0 -10000 0 -10000 0 0
complement component iC3b receptor activity 0 0 -10000 0 -10000 0 0
MMP2 0.029 0.015 -10000 0 0 108 108
JAM3 0.033 0.011 -10000 0 0 51 51
GP1BA 0.036 0.005 -10000 0 0 10 10
alphaM/beta2 Integrin/CTGF 0.021 0.085 -10000 0 -0.13 100 100
alphaM/beta2 Integrin 0.024 0.072 0.17 1 -0.24 15 16
JAM3 homodimer 0.033 0.011 -10000 0 0 51 51
ICAM2 0.034 0.009 -10000 0 0 31 31
ICAM1 0.031 0.014 -10000 0 0 84 84
phagocytosis triggered by activation of immune response cell surface activating receptor 0.025 0.075 0.17 1 -0.24 16 17
cell adhesion 0.048 0.068 -10000 0 -0.12 58 58
NFKB1 -0.002 0.078 0.2 23 -10000 0 23
THY1 0.031 0.013 -10000 0 0 79 79
RhoA/GDP 0.024 0.019 -10000 0 -0.13 7 7
Lipoprotein(a) 0.045 0.014 -10000 0 -10000 0 0
alphaM/beta2 Integrin/LRP/tPA 0.038 0.1 -10000 0 -0.14 107 107
IL6 -0.015 0.039 -10000 0 -10000 0 0
ITGB2 0.033 0.019 0.077 1 -10000 0 1
elevation of cytosolic calcium ion concentration 0.03 0.085 -10000 0 -0.14 68 68
alphaM/beta2 Integrin/JAM2/JAM3 0.049 0.1 -10000 0 -0.15 86 86
JAM2 0.033 0.012 -10000 0 0 57 57
alphaM/beta2 Integrin/ICAM1 0.077 0.076 -10000 0 -0.12 44 44
alphaM/beta2 Integrin/uPA/Plg 0.041 0.08 -10000 0 -0.13 60 60
RhoA/GTP 0.029 0.073 0.17 11 -0.24 14 25
positive regulation of phagocytosis 0.017 0.1 0.19 2 -0.24 48 50
Ron/MSP 0.051 0.014 -10000 0 -10000 0 0
alphaM/beta2 Integrin/uPAR/uPA 0.032 0.087 -10000 0 -0.14 68 68
alphaM/beta2 Integrin/uPAR 0.038 0.076 -10000 0 -0.13 63 63
PLAU 0.019 0.018 -10000 0 0 237 237
PLAT 0.027 0.016 -10000 0 0 128 128
actin filament polymerization 0.027 0.073 0.21 6 -0.27 8 14
MST1 0.035 0.008 -10000 0 0 25 25
alphaM/beta2 Integrin/lipoprotein(a) 0.062 0.068 -10000 0 -0.1 54 54
TNF 0.006 0.088 0.21 19 -10000 0 19
RAP1B 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/uPA 0.019 0.073 -10000 0 -0.14 64 64
fibrinolysis 0.039 0.079 -10000 0 -0.13 55 55
HCK 0.027 0.016 -10000 0 0 128 128
dendritic cell antigen processing and presentation 0.025 0.075 0.17 1 -0.24 16 17
VTN 0.036 0.004 -10000 0 0 6 6
alphaM/beta2 Integrin/CYR61 0.011 0.092 -10000 0 -0.14 119 119
LPA 0.034 0.009 -10000 0 0 33 33
LRP1 0.031 0.013 -10000 0 0 71 71
cell migration 0.001 0.11 0.15 36 -0.14 146 182
FN1 0.035 0.009 -10000 0 0 29 29
alphaM/beta2 Integrin/Thy1 0.031 0.084 -10000 0 -0.13 87 87
MPO 0.036 0.004 -10000 0 0 5 5
KNG1 0.035 0.008 -10000 0 0 28 28
RAP1/GDP 0.024 0.007 -10000 0 -0.11 1 1
ROCK1 0.025 0.073 0.19 2 -0.27 11 13
ELA2 0.034 0.009 -10000 0 0 32 32
PLG 0.034 0.01 -10000 0 0 37 37
CTGF 0.026 0.016 -10000 0 0 141 141
alphaM/beta2 Integrin/Hck 0.031 0.092 -10000 0 -0.18 70 70
ITGAM 0.042 0.01 0.08 2 -10000 0 2
alphaM/beta2 Integrin/P-Selectin/PSGL1 0.071 0.072 -10000 0 -0.12 53 53
HP 0.027 0.016 -10000 0 0 136 136
leukocyte adhesion 0.023 0.12 0.2 1 -0.25 36 37
SELP 0.036 0.006 -10000 0 0 14 14
Glypican 2 network

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK 0.03 0.014 -9999 0 0 92 92
GPC2 0 0 -9999 0 -10000 0 0
GPC2/Midkine 0.007 0.05 -9999 0 -0.13 57 57
neuron projection morphogenesis 0.007 0.05 -9999 0 -0.13 57 57
IL23-mediated signaling events

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.064 0.6 0.76 31 -1 126 157
IL23A 0.089 0.37 0.78 20 -0.95 23 43
NF kappa B1 p50/RelA/I kappa B alpha 0.08 0.34 0.61 31 -0.84 25 56
positive regulation of T cell mediated cytotoxicity 0.088 0.4 0.76 37 -0.91 27 64
ITGA3 0.088 0.36 0.74 23 -0.89 23 46
IL17F 0.034 0.27 0.51 34 -0.59 28 62
IL12B 0.061 0.079 0.2 70 -0.075 2 72
STAT1 (dimer) 0.07 0.36 0.64 35 -0.89 27 62
CD4 0.071 0.42 0.72 36 -1 33 69
IL23 0.096 0.36 0.73 18 -0.93 22 40
IL23R 0.067 0.14 0.3 81 -0.15 11 92
IL1B 0.083 0.4 0.75 30 -1.1 26 56
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 0.097 0.36 0.68 38 -0.85 22 60
TYK2 0.043 0.059 0.15 49 -10000 0 49
STAT4 0.035 0.009 -10000 0 0 29 29
STAT3 0.034 0.01 -10000 0 0 37 37
IL18RAP 0.035 0.008 -10000 0 -0.031 4 4
IL12RB1 0.045 0.059 0.15 53 -10000 0 53
PIK3CA 0.031 0.013 -10000 0 0 80 80
IL12Rbeta1/TYK2 0.055 0.074 0.19 38 -0.13 11 49
IL23R/JAK2 0.1 0.16 0.39 72 -0.19 16 88
positive regulation of chronic inflammatory response 0.088 0.4 0.76 37 -0.91 27 64
natural killer cell activation -0.005 0.011 -10000 0 -0.03 40 40
JAK2 0.056 0.079 0.2 68 -0.075 2 70
PIK3R1 0.032 0.012 -10000 0 0 63 63
NFKB1 0.039 0.009 0.066 2 0 18 20
RELA 0.039 0.008 0.066 2 0 9 11
positive regulation of dendritic cell antigen processing and presentation 0.098 0.35 0.73 18 -0.88 23 41
ALOX12B 0.085 0.36 0.69 30 -0.85 24 54
CXCL1 0.095 0.37 0.74 37 -0.85 24 61
T cell proliferation 0.088 0.4 0.76 37 -0.91 27 64
NFKBIA 0.036 0.014 0.066 2 0 57 59
IL17A 0.058 0.24 0.45 55 -0.46 29 84
PI3K 0.046 0.35 0.62 27 -0.86 27 54
IFNG 0.019 0.033 0.1 26 -0.089 3 29
STAT3 (dimer) 0.048 0.35 0.61 27 -0.83 28 55
IL18R1 0.035 0.008 -10000 0 -0.032 5 5
IL23/IL23R/JAK2/TYK2/SOCS3 0.094 0.27 0.55 51 -0.51 22 73
IL18/IL18R 0.062 0.035 -10000 0 -0.12 7 7
macrophage activation -0.002 0.016 0.038 1 -0.042 18 19
TNF 0.091 0.36 0.77 19 -0.91 21 40
STAT3/STAT4 0.068 0.36 0.61 29 -0.88 27 56
STAT4 (dimer) 0.07 0.36 0.63 30 -0.89 27 57
IL18 0.031 0.013 -10000 0 -0.03 1 1
IL19 0.098 0.36 0.69 32 -0.85 22 54
STAT5A (dimer) 0.083 0.37 0.64 35 -0.88 27 62
STAT1 0.034 0.01 -10000 0 0 40 40
SOCS3 0.036 0.004 -10000 0 0 7 7
CXCL9 0.099 0.37 0.72 37 -0.84 25 62
MPO 0.086 0.36 0.7 27 -0.86 22 49
positive regulation of humoral immune response 0.088 0.4 0.76 37 -0.91 27 64
IL23/IL23R/JAK2/TYK2 0.086 0.4 0.76 37 -0.95 26 63
IL6 0.15 0.37 0.74 44 -0.86 21 65
STAT5A 0.036 0.004 -10000 0 0 5 5
IL2 0.022 0.03 -10000 0 -0.036 102 102
positive regulation of tyrosine phosphorylation of STAT protein -0.005 0.011 -10000 0 -0.03 40 40
CD3E 0.086 0.36 0.7 29 -0.88 20 49
keratinocyte proliferation 0.088 0.4 0.76 37 -0.91 27 64
NOS2 0.087 0.36 0.67 38 -0.82 27 65
JNK signaling in the CD4+ TCR pathway

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.069 0.057 -10000 0 -0.12 32 32
MAP4K1 0.035 0.008 -10000 0 0 26 26
MAP3K8 0.022 0.018 -10000 0 0 196 196
PRKCB 0 0 -10000 0 -10000 0 0
DBNL 0 0 -10000 0 -10000 0 0
CRKL 0.035 0.009 -10000 0 0 29 29
MAP3K1 0 0.054 0.13 1 -0.16 32 33
JUN -0.14 0.24 -10000 0 -0.51 138 138
MAP3K7 0 0.052 -10000 0 -0.17 30 30
GRAP2 0.034 0.009 -10000 0 0 35 35
CRK 0.035 0.008 -10000 0 0 23 23
MAP2K4 -0.016 0.071 0.15 1 -0.24 22 23
LAT 0.036 0.005 -10000 0 0 10 10
LCP2 0.031 0.013 -10000 0 0 77 77
MAPK8 -0.13 0.25 -10000 0 -0.54 138 138
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.01 0.056 -10000 0 -0.16 33 33
LAT/GRAP2/SLP76/HPK1/HIP-55 0.063 0.054 -10000 0 -0.11 32 32
Osteopontin-mediated events

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.002 0.077 0.19 3 -0.19 38 41
NF kappa B1 p50/RelA/I kappa B alpha -0.019 0.12 0.25 1 -0.32 44 45
alphaV/beta3 Integrin/Osteopontin/Src 0.026 0.081 -10000 0 -0.16 74 74
AP1 -0.011 0.14 0.28 6 -0.27 81 87
ILK -0.031 0.072 0.2 2 -0.23 33 35
bone resorption -0.039 0.083 0.18 6 -0.24 34 40
PTK2B 0.035 0.006 -10000 0 0 16 16
PYK2/p130Cas 0.045 0.09 -10000 0 -0.16 61 61
ITGAV 0.031 0.026 -10000 0 -0.056 35 35
mol:GTP 0 0 -10000 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.02 0.068 -10000 0 -0.14 73 73
alphaV/beta3 Integrin/Osteopontin 0.05 0.092 -10000 0 -0.16 72 72
MAP3K1 -0.03 0.063 0.22 1 -0.2 27 28
JUN 0.034 0.01 -10000 0 0 40 40
MAPK3 -0.031 0.085 0.18 7 -0.24 41 48
MAPK1 -0.029 0.086 0.17 12 -0.25 38 50
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
NFKB1 0.035 0.007 -10000 0 0 18 18
MAPK8 -0.027 0.059 0.23 1 -0.2 26 27
ITGB3 0.032 0.026 -10000 0 -0.055 39 39
NFKBIA -0.038 0.11 0.18 5 -0.31 46 51
FOS 0.026 0.017 -10000 0 0 158 158
CD44 0.029 0.015 -10000 0 0 110 110
CHUK 0.025 0.017 -10000 0 0 163 163
PLAU -0.071 0.25 -10000 0 -0.97 32 32
NF kappa B1 p50/RelA -0.001 0.12 -10000 0 -0.33 39 39
BCAR1 0 0 -10000 0 -10000 0 0
RELA 0.036 0.005 -10000 0 0 9 9
alphaV beta3 Integrin 0.04 0.058 -10000 0 -0.13 39 39
mol:GDP 0 0 -10000 0 -10000 0 0
SYK -0.032 0.065 0.19 2 -0.23 29 31
VAV3 -0.024 0.072 0.15 6 -0.22 33 39
MAP3K14 -0.028 0.074 0.17 5 -0.21 35 40
ROCK2 0.035 0.007 -10000 0 0 21 21
SPP1 0.03 0.026 -10000 0 -0.058 29 29
RAC1 0.024 0.017 -10000 0 0 173 173
Rac1/GTP -0.021 0.07 0.14 4 -0.22 29 33
MMP2 -0.061 0.12 -10000 0 -0.32 61 61
PLK2 and PLK4 events

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.031 0.014 -10000 0 0 83 83
PLK4 0.035 0.007 -10000 0 0 20 20
regulation of centriole replication -0.011 0.032 0.092 43 -9999 0 43
Ephrin B reverse signaling

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.028 0.015 -10000 0 0 116 116
EPHB2 0.034 0.011 -10000 0 0 42 42
EFNB1 -0.017 0.02 0.084 8 -10000 0 8
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.047 0.053 -10000 0 -0.12 13 13
Ephrin B2/EPHB1-2 0.031 0.056 -10000 0 -0.1 52 52
neuron projection morphogenesis 0.032 0.041 -10000 0 -0.12 13 13
Ephrin B1/EPHB1-2/Tiam1 0.057 0.049 -10000 0 -0.1 28 28
DNM1 0.035 0.008 -10000 0 0 26 26
cell-cell signaling 0 0.003 0.023 1 -10000 0 1
MAP2K4 -0.054 0.16 0.2 1 -0.52 52 53
YES1 -0.055 0.24 -10000 0 -0.75 52 52
Ephrin B1/EPHB1-2/NCK2 0.061 0.044 -10000 0 -0.1 20 20
PI3K -0.02 0.19 -10000 0 -0.56 51 51
mol:GDP 0.055 0.048 -10000 0 -0.1 28 28
ITGA2B 0.036 0.004 -10000 0 0 5 5
endothelial cell proliferation 0.015 0.047 -10000 0 -0.11 46 46
FYN -0.067 0.24 -10000 0 -0.77 52 52
MAP3K7 -0.051 0.16 0.22 1 -0.54 51 52
FGR -0.051 0.23 -10000 0 -0.73 51 51
TIAM1 0.033 0.011 -10000 0 0 46 46
PIK3R1 0.032 0.012 -10000 0 0 63 63
RGS3 0.035 0.008 -10000 0 0 23 23
cell adhesion -0.032 0.17 -10000 0 -0.53 51 51
LYN -0.062 0.23 -10000 0 -0.74 52 52
Ephrin B1/EPHB1-2/Src Family Kinases -0.057 0.21 -10000 0 -0.68 52 52
Ephrin B1/EPHB1-2 -0.048 0.18 -10000 0 -0.57 51 51
SRC -0.05 0.23 -10000 0 -0.72 52 52
ITGB3 0.036 0.003 -10000 0 0 4 4
EPHB1 0.03 0.015 -10000 0 0 95 95
EPHB4 0.025 0.017 -10000 0 0 166 166
RAC1 0.024 0.017 -10000 0 0 173 173
Ephrin B2/EPHB4 0.016 0.047 -10000 0 -0.11 46 46
alphaIIb/beta3 Integrin 0.054 0.006 -10000 0 -10000 0 0
BLK -0.052 0.23 -10000 0 -0.72 52 52
HCK -0.065 0.23 -10000 0 -0.74 52 52
regulation of stress fiber formation -0.059 0.043 0.1 20 -10000 0 20
MAPK8 -0.056 0.15 -10000 0 -0.49 52 52
Ephrin B1/EPHB1-2/RGS3 0.066 0.035 -10000 0 -0.11 6 6
endothelial cell migration 0.01 0.17 0.2 113 -0.45 43 156
NCK2 0.035 0.007 -10000 0 0 17 17
PTPN13 0.034 0.013 -10000 0 0 60 60
regulation of focal adhesion formation -0.059 0.043 0.1 20 -10000 0 20
chemotaxis -0.064 0.034 0.11 6 -10000 0 6
PIK3CA 0.031 0.013 -10000 0 0 80 80
Rac1/GTP 0.04 0.047 -10000 0 -0.12 13 13
angiogenesis -0.047 0.18 -10000 0 -0.57 51 51
LCK -0.049 0.23 -10000 0 -0.72 51 51
Signaling events mediated by VEGFR1 and VEGFR2

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin 0.044 0.042 -10000 0 -0.14 24 24
AKT1 -0.017 0.17 0.28 16 -0.43 43 59
PTK2B -0.001 0.11 0.2 56 -0.36 13 69
VEGFR2 homodimer/Frs2 0.026 0.082 0.18 5 -0.31 17 22
CAV1 0.016 0.018 -10000 0 0 290 290
CALM1 0.033 0.011 -10000 0 0 54 54
VEGFR2 homodimer/VEGFA homodimer/Frs2 0.022 0.085 0.18 2 -0.29 19 21
endothelial cell proliferation 0.011 0.14 0.28 30 -0.38 29 59
mol:Ca2+ 0.006 0.13 0.23 67 -0.32 20 87
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac 0.017 0.087 0.2 2 -0.27 23 25
RP11-342D11.1 -0.005 0.1 0.17 69 -0.23 46 115
CDH5 0.03 0.014 -10000 0 0 92 92
VEGFA homodimer 0.036 0.034 -10000 0 -0.094 14 14
SHC1 0.033 0.011 -10000 0 0 52 52
SHC2 0.032 0.012 -10000 0 0 64 64
HRAS/GDP 0.005 0.09 -10000 0 -0.24 46 46
SH2D2A 0.036 0.006 -10000 0 0 15 15
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS 0.021 0.11 0.26 5 -0.33 24 29
VEGFR2 homodimer/VEGFA homodimer/TsAd 0.022 0.086 0.18 2 -0.3 19 21
VEGFR1 homodimer 0.034 0.009 -10000 0 0 33 33
SHC/GRB2/SOS1 0.036 0.1 -10000 0 -0.23 47 47
GRB10 -0.011 0.11 0.21 32 -0.32 34 66
PTPN11 0.036 0.005 -10000 0 0 11 11
GRB2 0.035 0.007 -10000 0 0 17 17
PAK1 0.036 0.006 -10000 0 0 15 15
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin 0.037 0.12 0.22 2 -0.27 38 40
HRAS 0.034 0.009 -10000 0 0 32 32
VEGF/Rho/ROCK1/Integrin Complex 0.012 0.1 0.18 5 -0.32 30 35
HIF1A 0.033 0.01 -10000 0 0 44 44
FRS2 0.034 0.009 -10000 0 0 30 30
oxygen and reactive oxygen species metabolic process 0.016 0.085 0.19 2 -0.27 23 25
mol:GTP 0 0 -10000 0 -10000 0 0
FLT4 0.036 0.006 -10000 0 0 12 12
Nck/Pak 0.049 0.023 -10000 0 -0.14 5 5
VEGFR2 homodimer/VEGFA homodimer/Fyn 0.01 0.1 0.18 2 -0.28 32 34
mol:GDP 0.017 0.093 -10000 0 -0.23 47 47
mol:NADP 0.032 0.12 0.3 22 -0.32 19 41
eNOS/Hsp90 0.029 0.12 0.29 21 -0.3 20 41
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 0.006 0.13 0.23 67 -0.32 20 87
HIF1A/ARNT 0.046 0.031 -10000 0 -0.14 11 11
SHB 0.033 0.011 -10000 0 0 51 51
VEGFA -0.003 0.013 -10000 0 -0.039 52 52
VEGFC 0.033 0.011 -10000 0 0 51 51
FAK1/Vinculin 0.012 0.12 0.26 13 -0.44 19 32
mol:Ca ++ 0 0 -10000 0 -10000 0 0
RHOA 0.035 0.007 -10000 0 0 18 18
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.037 0.1 0.2 5 -0.28 26 31
PTPN6 0.033 0.011 -10000 0 0 51 51
EPAS1 0.032 0.062 -10000 0 -0.26 14 14
mol:L-citrulline 0.032 0.12 0.3 22 -0.32 19 41
ITGAV 0.034 0.009 -10000 0 0 31 31
PIK3CA 0.031 0.013 -10000 0 0 80 80
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.039 0.094 0.2 5 -0.27 22 27
VEGFR2 homodimer/VEGFA homodimer 0.012 0.097 -10000 0 -0.25 47 47
VEGFR2/3 heterodimer 0.026 0.084 0.18 5 -0.31 18 23
VEGFB 0.036 0.005 -10000 0 0 8 8
MAPK11 0.009 0.13 0.28 37 -0.34 20 57
VEGFR2 homodimer -0.006 0.081 0.17 4 -0.38 15 19
FLT1 0.034 0.009 -10000 0 0 33 33
NEDD4 0.029 0.033 0.092 7 -0.057 53 60
MAPK3 0.012 0.12 0.28 41 -0.3 20 61
MAPK1 0.01 0.13 0.27 43 -0.29 21 64
VEGFA145/NRP2 0.023 0.022 -10000 0 -0.047 5 5
VEGFR1/2 heterodimer 0.024 0.083 0.18 4 -0.32 17 21
KDR -0.006 0.082 0.17 4 -0.38 15 19
VEGFA165/NRP1/VEGFR2 homodimer 0.024 0.098 0.2 12 -0.23 47 59
SRC 0.036 0.006 -10000 0 0 14 14
platelet activating factor biosynthetic process 0.012 0.13 0.28 42 -0.3 20 62
PI3K -0.001 0.14 0.27 18 -0.38 34 52
VEGFR2 homodimer/VEGFA homodimer/NCK1 0.021 0.086 0.18 2 -0.3 19 21
FES 0.007 0.13 0.24 68 -0.33 19 87
GAB1 0.012 0.12 0.24 16 -0.36 26 42
VEGFR2 homodimer/VEGFA homodimer/Src 0.021 0.086 0.17 1 -0.3 19 20
CTNNB1 0.036 0.006 -10000 0 0 15 15
SOS1 0 0 -10000 0 -10000 0 0
ARNT 0.036 0.004 -10000 0 0 5 5
eNOS/Caveolin-1 0.009 0.095 0.29 4 -0.34 16 20
VEGFR2 homodimer/VEGFA homodimer/Yes 0.018 0.09 0.18 1 -0.3 21 22
PI3K/GAB1 -0.003 0.16 0.27 24 -0.4 46 70
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak 0.06 0.097 0.23 2 -0.26 19 21
PRKACA 0.035 0.008 -10000 0 0 25 25
VEGFR2/3 heterodimer/VEGFC homodimer 0.038 0.08 0.2 1 -0.28 16 17
HSP90AA1 0 0 -10000 0 -10000 0 0
CDC42 0.007 0.13 0.23 67 -0.34 17 84
actin cytoskeleton reorganization 0.022 0.086 0.18 2 -0.3 19 21
PTK2 0.009 0.13 0.25 22 -0.45 20 42
EDG1 0 0.14 0.23 66 -0.34 30 96
mol:DAG 0.006 0.13 0.23 67 -0.32 20 87
CaM/Ca2+ 0.02 0.12 0.26 29 -0.24 47 76
MAP2K3 0 0.12 0.23 55 -0.32 18 73
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 0.046 0.14 0.23 102 -0.3 43 145
PLCG1 0.006 0.13 0.23 67 -0.33 20 87
VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.035 0.091 0.2 4 -0.28 19 23
IQGAP1 0.033 0.011 -10000 0 0 51 51
YES1 0.034 0.01 -10000 0 0 41 41
VEGFR2 homodimer/VEGFA homodimer/SHP2 0.021 0.089 0.18 2 -0.3 21 23
VEGFR2 homodimer/VEGFA homodimer/SHP1 0.019 0.086 0.18 2 -0.28 20 22
cell migration 0.007 0.14 0.25 23 -0.38 33 56
mol:PI-3-4-5-P3 0.001 0.14 0.25 22 -0.35 34 56
FYN 0.03 0.014 -10000 0 0 90 90
VEGFB/NRP1 0.006 0.12 0.22 67 -0.32 18 85
mol:NO 0.032 0.12 0.3 22 -0.32 19 41
PXN 0.036 0.004 -10000 0 0 7 7
HRAS/GTP -0.045 0.069 -10000 0 -0.24 46 46
VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.006 0.097 -10000 0 -0.3 43 43
VHL 0 0 -10000 0 -10000 0 0
ITGB3 0.036 0.003 -10000 0 0 4 4
NOS3 0.031 0.13 0.32 19 -0.35 20 39
VEGFR2 homodimer/VEGFA homodimer/Sck 0.015 0.093 -10000 0 -0.28 27 27
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCA 0 0.12 0.23 58 -0.31 20 78
PRKCB 0.004 0.12 0.22 67 -0.3 20 87
VCL 0.025 0.017 -10000 0 0 154 154
VEGFA165/NRP1 -0.025 0.082 0.12 39 -0.23 47 86
VEGFR1/2 heterodimer/VEGFA homodimer 0.02 0.086 0.18 2 -0.3 19 21
VEGFA165/NRP2 0.023 0.022 -10000 0 -0.047 5 5
MAPKKK cascade -0.031 0.091 0.17 8 -0.32 33 41
NRP2 0.036 0.005 -10000 0 0 8 8
VEGFC homodimer 0.033 0.011 -10000 0 0 51 51
NCK1 0.035 0.008 -10000 0 0 27 27
ROCK1 0.036 0.006 -10000 0 0 15 15
FAK1/Paxillin 0.027 0.13 0.26 17 -0.43 20 37
MAP3K13 0.007 0.13 0.24 66 -0.33 18 84
PDPK1 -0.017 0.13 0.22 37 -0.34 31 68
Presenilin action in Notch and Wnt signaling

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) -0.032 0.17 -10000 0 -0.47 65 65
HDAC1 0.027 0.034 0.089 21 -0.039 84 105
AES 0.033 0.013 0.071 8 -0.004 46 54
FBXW11 0.035 0.008 -10000 0 0 25 25
DTX1 0 0 -10000 0 -10000 0 0
LRP6/FZD1 0.033 0.027 -10000 0 -10000 0 0
TLE1 0.034 0.013 0.068 8 -0.007 36 44
AP1 -0.01 0.073 -10000 0 -0.2 55 55
NCSTN 0.035 0.008 -10000 0 0 28 28
ADAM10 0.033 0.012 -10000 0 0 56 56
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.011 0.12 -10000 0 -0.52 8 8
NICD/RBPSUH -0.035 0.17 -10000 0 -0.47 65 65
WIF1 0.028 0.015 -10000 0 0 112 112
NOTCH1 -0.031 0.18 -10000 0 -0.49 64 64
PSENEN 0.035 0.008 -10000 0 0 28 28
KREMEN2 0.036 0.004 -10000 0 0 7 7
DKK1 0.017 0.018 -10000 0 0 271 271
beta catenin/beta TrCP1 0.062 0.091 0.23 18 -0.3 8 26
APH1B 0.035 0.006 -10000 0 0 16 16
APH1A 0.036 0.005 -10000 0 0 11 11
AXIN1 0.013 0.065 0.25 1 -10000 0 1
CtBP/CBP/TCF1/TLE1/AES 0.012 0.072 0.17 48 -0.18 19 67
PSEN1 0.033 0.011 -10000 0 0 46 46
FOS 0.025 0.017 -10000 0 0 158 158
JUN 0.034 0.01 -10000 0 0 40 40
MAP3K7 0.032 0.018 0.062 9 -0.011 61 70
CTNNB1 0.048 0.088 0.22 24 -0.3 6 30
MAPK3 0.036 0.004 -10000 0 0 6 6
DKK2/LRP6/Kremen 2 0.064 0.027 -10000 0 -0.12 1 1
HNF1A 0 0.006 0.032 9 -10000 0 9
CTBP1 0.034 0.013 0.072 6 -0.007 34 40
MYC -0.079 0.37 -10000 0 -1.2 50 50
NKD1 0 0.003 -10000 0 -10000 0 0
FZD1 0.024 0.017 -10000 0 0 173 173
NOTCH1 precursor/Deltex homolog 1 -0.035 0.17 -10000 0 -0.47 65 65
apoptosis -0.01 0.073 -10000 0 -0.2 56 56
Delta 1/NOTCHprecursor -0.035 0.17 -10000 0 -0.47 65 65
DLL1 0 0 -10000 0 -10000 0 0
PPARD 0.025 0.036 -10000 0 -10000 0 0
Gamma Secretase 0.08 0.07 -10000 0 -0.15 28 28
APC -0.023 0.17 0.23 1 -0.62 31 32
DVL1 0.019 0.096 -10000 0 -0.41 18 18
CSNK2A1 0.034 0.009 -10000 0 0 31 31
MAP3K7IP1 0.032 0.018 0.063 8 -0.012 55 63
DKK1/LRP6/Kremen 2 0.031 0.037 -10000 0 -10000 0 0
LRP6 0.034 0.01 -10000 0 0 40 40
CSNK1A1 0.036 0.006 -10000 0 0 14 14
NLK 0.011 0.051 0.13 1 -0.21 20 21
CCND1 -0.047 0.34 -10000 0 -1.2 40 40
WNT1 0.035 0.006 -10000 0 0 16 16
Axin1/APC/beta catenin 0.012 0.13 0.24 1 -0.42 29 30
DKK2 0.034 0.009 -10000 0 0 31 31
NOTCH1 precursor/DVL1 -0.009 0.19 -10000 0 -0.48 59 59
GSK3B 0.034 0.01 -10000 0 0 40 40
FRAT1 0.025 0.017 -10000 0 0 161 161
NOTCH/Deltex homolog 1 -0.032 0.17 -10000 0 -0.47 65 65
PPP2R5D 0.027 0.037 -10000 0 -0.25 4 4
MAPK1 0.033 0.01 -10000 0 0 45 45
WNT1/LRP6/FZD1 0.057 0.046 -10000 0 -10000 0 0
RBPJ 0 0 -10000 0 -10000 0 0
CREBBP 0.032 0.021 0.07 4 -0.019 62 66
FoxO family signaling

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.001 0.047 -10000 0 -10000 0 0
PLK1 -0.059 0.2 -10000 0 -0.79 12 12
CDKN1B -0.11 0.21 0.4 4 -0.39 108 112
FOXO3 -0.065 0.22 0.33 5 -0.49 81 86
KAT2B -0.001 0.021 0.047 17 -0.042 75 92
FOXO1/SIRT1 0.014 0.048 -10000 0 -0.24 5 5
CAT -0.075 0.26 -10000 0 -1.1 18 18
CTNNB1 0.036 0.006 -10000 0 0 15 15
AKT1 0.021 0.042 -10000 0 -0.063 54 54
FOXO1 0.004 0.051 0.22 1 -0.26 6 7
MAPK10 0.044 0.093 0.19 129 -0.15 18 147
mol:GTP -0.001 0.004 -10000 0 -0.021 1 1
FOXO4 -0.031 0.2 0.26 15 -0.44 63 78
response to oxidative stress 0 0.023 0.052 13 -0.049 35 48
FOXO3A/SIRT1 -0.06 0.21 -10000 0 -0.47 83 83
XPO1 0.036 0.004 -10000 0 0 5 5
EP300 0.034 0.011 -10000 0 -10000 0 0
BCL2L11 0.024 0.031 -10000 0 -10000 0 0
FOXO1/SKP2 0.02 0.054 -10000 0 -0.24 6 6
mol:GDP 0 0.023 0.052 13 -0.049 35 48
RAN 0.034 0.011 -10000 0 -0.015 20 20
GADD45A -0.15 0.33 0.47 1 -0.87 68 69
YWHAQ 0.036 0.005 -10000 0 0 9 9
FOXO1/14-3-3 family 0.005 0.15 -10000 0 -0.56 19 19
MST1 0.022 0.043 0.11 1 -0.06 84 85
CSNK1D 0.035 0.007 -10000 0 0 20 20
CSNK1E 0.032 0.012 -10000 0 0 67 67
FOXO4/14-3-3 family -0.003 0.15 -10000 0 -0.46 29 29
YWHAB 0.035 0.008 -10000 0 0 24 24
MAPK8 0.024 0.076 0.18 76 -0.14 12 88
MAPK9 0.052 0.097 0.19 150 -0.15 15 165
YWHAG 0 0 -10000 0 -10000 0 0
YWHAE 0.035 0.008 -10000 0 0 27 27
YWHAZ 0.035 0.007 -10000 0 0 21 21
SIRT1 0.019 0.023 -10000 0 -0.035 38 38
SOD2 -0.14 0.35 0.42 4 -0.79 92 96
RBL2 -0.072 0.28 -10000 0 -0.93 36 36
RAL/GDP 0.018 0.049 -10000 0 -0.14 20 20
CHUK 0.012 0.038 -10000 0 -0.059 71 71
Ran/GTP 0.019 0.025 -10000 0 -0.12 6 6
CSNK1G2 0.034 0.009 -10000 0 0 30 30
RAL/GTP 0.017 0.051 0.14 2 -0.13 20 22
CSNK1G1 0.036 0.006 -10000 0 0 14 14
FASLG 0.022 0.041 -10000 0 -0.59 1 1
SKP2 0.035 0.006 -10000 0 0 16 16
USP7 0.034 0.011 -10000 0 -0.012 23 23
IKBKB 0.023 0.044 0.11 1 -0.06 89 90
CCNB1 -0.16 0.42 0.49 1 -1.1 83 84
FOXO1-3a-4/beta catenin -0.039 0.21 0.36 12 -0.4 78 90
proteasomal ubiquitin-dependent protein catabolic process 0.02 0.054 -10000 0 -0.24 6 6
CSNK1A1 0.036 0.006 -10000 0 0 14 14
SGK1 -0.001 0.021 0.047 17 -0.042 75 92
CSNK1G3 0.036 0.006 -10000 0 0 13 13
Ran/GTP/Exportin 1 0.039 0.036 -10000 0 -0.12 9 9
ZFAND5 -0.019 0.16 0.24 16 -0.35 62 78
SFN 0.031 0.013 -10000 0 0 78 78
CDK2 0.036 0.012 -10000 0 -0.031 3 3
FOXO3A/14-3-3 -0.012 0.16 -10000 0 -0.47 31 31
CREBBP 0.038 0.008 -10000 0 -0.031 3 3
FBXO32 -0.059 0.2 0.32 1 -0.44 81 82
BCL6 -0.093 0.32 -10000 0 -0.99 47 47
RALB 0.033 0.013 -10000 0 -0.015 32 32
RALA 0.023 0.018 -10000 0 -0.001 184 184
YWHAH 0.031 0.013 -10000 0 0 73 73
FAS signaling pathway (CD95)

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 -0.017 0.056 0.22 8 -0.21 21 29
RFC1 -0.02 0.048 0.18 2 -0.21 25 27
PRKDC -0.016 0.055 0.19 7 -0.21 23 30
RIPK1 0.027 0.021 -10000 0 -0.023 73 73
CASP7 -0.16 0.28 -10000 0 -0.57 162 162
FASLG/FAS/FADD/FAF1 -0.012 0.083 0.16 27 -0.18 44 71
MAP2K4 -0.043 0.14 0.21 2 -0.31 41 43
mol:ceramide 0.004 0.089 0.18 5 -0.23 19 24
GSN -0.008 0.058 0.19 11 -0.22 19 30
FASLG/FAS/FADD/FAF1/Caspase 8 -0.011 0.093 0.18 12 -0.24 25 37
FAS 0.021 0.02 -10000 0 0 238 238
BID -0.031 0.033 0.076 9 -0.13 21 30
MAP3K1 -0.1 0.19 -10000 0 -0.36 166 166
MAP3K7 0.035 0.01 -10000 0 0 41 41
RB1 -0.017 0.045 0.23 1 -0.21 23 24
CFLAR 0.029 0.021 -10000 0 -0.027 59 59
HGF/MET 0.034 0.049 -10000 0 -0.12 22 22
ARHGDIB -0.016 0.055 0.22 6 -0.22 21 27
FADD 0.038 0.007 -10000 0 -10000 0 0
actin filament polymerization 0.008 0.058 0.21 19 -0.19 11 30
NFKB1 0.029 0.1 -10000 0 -0.63 10 10
MAPK8 -0.033 0.13 0.23 2 -0.34 22 24
DFFA -0.017 0.048 0.22 3 -0.21 24 27
DNA fragmentation during apoptosis -0.016 0.046 0.22 2 -0.2 24 26
FAS/FADD/MET 0.025 0.052 -10000 0 -0.12 27 27
CFLAR/RIP1 0.048 0.02 -10000 0 -0.13 2 2
FAIM3 0.033 0.009 -10000 0 0 36 36
FAF1 0.038 0.012 -10000 0 -10000 0 0
PARP1 -0.019 0.048 0.22 1 -0.21 26 27
DFFB -0.016 0.046 0.22 2 -0.21 23 25
CHUK 0.015 0.096 -10000 0 -0.6 10 10
FASLG 0.039 0.008 -10000 0 -10000 0 0
FAS/FADD 0.021 0.053 -10000 0 -0.14 34 34
HGF 0.024 0.017 -10000 0 0 177 177
LMNA -0.02 0.049 0.2 5 -0.19 24 29
CASP6 -0.017 0.047 0.17 3 -0.2 24 27
CASP10 0.039 0.004 -10000 0 -10000 0 0
CASP3 -0.011 0.05 -10000 0 -0.22 25 25
PTPN13 0.032 0.012 -10000 0 0 60 60
CASP8 -0.029 0.013 0.084 3 -10000 0 3
IL6 0.02 0.13 -10000 0 -0.61 6 6
MET 0.023 0.018 -10000 0 0 191 191
ICAD/CAD -0.021 0.049 0.25 4 -0.2 23 27
FASLG/FAS/FADD/FAF1/Caspase 10 0.004 0.09 0.18 5 -0.24 19 24
activation of caspase activity by cytochrome c -0.031 0.033 0.073 26 -0.13 23 49
PAK2 -0.015 0.049 0.14 2 -0.2 25 27
BCL2 0.035 0.007 -10000 0 0 20 20
IL2 signaling events mediated by PI3K

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.004 0.093 -10000 0 -0.4 5 5
UGCG -0.027 0.19 -10000 0 -0.74 31 31
AKT1/mTOR/p70S6K/Hsp90/TERT -0.006 0.13 0.26 8 -0.34 38 46
mol:GTP 0 0.001 -10000 0 -10000 0 0
mol:glucosylceramide -0.026 0.19 -10000 0 -0.72 31 31
mol:DAG -0.007 0.032 0.17 15 -10000 0 15
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.024 0.18 0.29 8 -0.42 62 70
FRAP1 -0.034 0.2 0.3 9 -0.48 61 70
FOXO3 -0.033 0.2 0.3 8 -0.46 64 72
AKT1 -0.039 0.21 0.31 7 -0.5 64 71
GAB2 0.03 0.019 -10000 0 -0.012 80 80
SMPD1 0.003 0.09 -10000 0 -0.49 14 14
SGMS1 -0.003 0.034 0.066 18 -0.07 73 91
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP -0.028 0.045 0.094 5 -0.13 73 78
CALM1 0.033 0.011 -10000 0 0 54 54
cell proliferation -0.032 0.19 0.28 10 -0.39 69 79
EIF3A 0 0 -10000 0 -10000 0 0
PI3K 0.018 0.077 -10000 0 -0.16 73 73
RPS6KB1 0.029 0.027 -10000 0 -10000 0 0
mol:sphingomyelin -0.007 0.032 0.17 15 -10000 0 15
natural killer cell activation 0 0.003 0.007 26 -0.01 45 71
JAK3 0.034 0.016 -10000 0 -0.028 22 22
PIK3R1 0.031 0.019 -10000 0 -0.029 24 24
JAK1 0.032 0.019 -10000 0 -0.028 29 29
NFKB1 0.035 0.007 -10000 0 0 18 18
MYC -0.065 0.29 0.45 7 -0.83 56 63
MYB 0.034 0.041 -10000 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.025 0.16 0.25 9 -0.38 55 64
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.038 0.032 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.023 0.16 0.26 10 -0.37 54 64
Rac1/GDP 0.004 0.05 0.12 6 -0.13 46 52
T cell proliferation -0.023 0.15 0.26 8 -0.35 53 61
SHC1 0.029 0.019 -10000 0 -0.011 85 85
RAC1 0.024 0.017 -10000 0 0 173 173
positive regulation of cyclin-dependent protein kinase activity 0.005 0.012 0.057 24 -10000 0 24
PRKCZ -0.025 0.15 0.26 8 -0.36 54 62
NF kappa B1 p50/RelA -0.011 0.19 0.31 8 -0.43 61 69
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K 0.006 0.094 0.21 3 -0.31 20 23
HSP90AA1 0 0 -10000 0 -10000 0 0
RELA 0.036 0.005 -10000 0 0 9 9
IL2RA 0.021 0.021 -10000 0 -0.004 198 198
IL2RB 0.032 0.018 -10000 0 -0.028 22 22
TERT 0.036 0.006 -10000 0 0 14 14
E2F1 0.036 0.031 -10000 0 -10000 0 0
SOS1 0 0.003 0.008 32 -0.009 44 76
RPS6 0.031 0.013 -10000 0 0 81 81
mol:cAMP -0.003 0.007 -10000 0 -0.031 25 25
PTPN11 0.032 0.018 -10000 0 -0.023 47 47
IL2RG 0.034 0.017 -10000 0 -0.03 24 24
actin cytoskeleton organization -0.023 0.15 0.26 8 -0.35 53 61
GRB2 0.033 0.016 -10000 0 -0.017 42 42
IL2 0.035 0.016 -10000 0 -0.03 24 24
PIK3CA 0.03 0.02 -10000 0 -0.029 26 26
Rac1/GTP 0.026 0.064 0.16 5 -0.12 46 51
LCK 0.034 0.017 -10000 0 -0.03 25 25
BCL2 -0.02 0.16 -10000 0 -0.43 35 35
BCR signaling pathway

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN 0.003 0.12 0.26 3 -0.31 31 34
IKBKB 0.017 0.078 0.26 4 -0.29 5 9
AKT1 0.001 0.083 0.22 27 -0.18 13 40
IKBKG 0.009 0.07 0.23 1 -0.24 9 10
CALM1 -0.029 0.12 0.21 3 -0.35 46 49
PIK3CA 0.031 0.013 -10000 0 0 80 80
MAP3K1 0.027 0.13 0.28 10 -0.34 31 41
MAP3K7 0.034 0.01 -10000 0 0 41 41
mol:Ca2+ -0.027 0.13 0.22 4 -0.37 45 49
DOK1 0.036 0.002 -10000 0 0 2 2
AP-1 -0.009 0.092 0.19 11 -0.22 38 49
LYN 0.031 0.013 -10000 0 0 74 74
BLNK 0.019 0.018 -10000 0 0 243 243
SHC1 0.033 0.011 -10000 0 0 52 52
BCR complex 0.05 0.015 -10000 0 -10000 0 0
CD22 -0.016 0.092 -10000 0 -0.29 35 35
CAMK2G -0.018 0.12 0.21 4 -0.33 45 49
CSNK2A1 0.034 0.009 -10000 0 0 31 31
INPP5D 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.036 0.054 -10000 0 -0.2 24 24
GO:0007205 -0.028 0.14 0.22 4 -0.38 45 49
SYK 0.031 0.013 -10000 0 0 76 76
ELK1 -0.033 0.13 0.21 4 -0.36 45 49
NFATC1 -0.017 0.092 0.25 4 -0.26 32 36
B-cell antigen/BCR complex 0.05 0.015 -10000 0 -10000 0 0
PAG1/CSK 0.023 0.022 -10000 0 -0.13 10 10
NFKBIB 0.02 0.042 0.14 1 -0.13 19 20
HRAS -0.028 0.12 0.18 7 -0.31 49 56
NFKBIA 0.02 0.039 0.14 1 -0.12 15 16
NF-kappa-B/RelA/I kappa B beta 0.025 0.038 0.14 1 -0.11 11 12
RasGAP/Csk 0.045 0.096 -10000 0 -0.12 113 113
mol:GDP -0.026 0.13 0.22 4 -0.36 45 49
PTEN 0.026 0.017 -10000 0 0 148 148
CD79B 0.036 0.005 -10000 0 0 10 10
NF-kappa-B/RelA/I kappa B alpha 0.025 0.036 0.14 1 -0.11 8 9
GRB2 0.035 0.007 -10000 0 0 17 17
PI3K/BCAP/CD19 -0.038 0.16 0.38 1 -0.43 45 46
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 -0.026 0.13 0.23 4 -0.38 44 48
CSK 0.035 0.007 -10000 0 0 21 21
FOS -0.031 0.13 0.2 7 -0.35 48 55
CHUK -0.061 0.14 0.23 1 -0.26 124 125
IBTK 0.034 0.009 -10000 0 0 30 30
CARD11/BCL10/MALT1/TAK1 -0.003 0.13 0.23 1 -0.33 40 41
PTPN6 -0.021 0.094 0.18 8 -0.3 34 42
RELA 0.036 0.005 -10000 0 0 9 9
BCL2A1 0.017 0.034 0.095 12 -0.096 16 28
VAV2 -0.014 0.1 -10000 0 -0.31 34 34
ubiquitin-dependent protein catabolic process 0.021 0.042 0.14 1 -0.13 19 20
BTK 0.019 0.012 -10000 0 -10000 0 0
CD19 -0.016 0.093 -10000 0 -0.29 36 36
MAP4K1 0.035 0.008 -10000 0 0 26 26
CD72 0.033 0.011 -10000 0 0 55 55
PAG1 0 0 -10000 0 -10000 0 0
MAPK14 0.023 0.12 0.25 10 -0.3 31 41
SH3BP5 0.033 0.011 -10000 0 0 51 51
PIK3AP1 -0.023 0.14 0.23 4 -0.39 45 49
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.036 0.18 -10000 0 -0.52 49 49
RAF1 -0.033 0.11 0.19 5 -0.3 49 54
RasGAP/p62DOK/SHIP 0.037 0.084 -10000 0 -0.11 112 112
CD79A 0.034 0.009 -10000 0 0 34 34
re-entry into mitotic cell cycle -0.01 0.092 0.18 11 -0.22 39 50
RASA1 0.034 0.009 -10000 0 0 32 32
MAPK3 -0.038 0.096 0.18 3 -0.29 38 41
MAPK1 -0.037 0.099 0.19 4 -0.3 39 43
CD72/SHP1 -0.002 0.1 0.26 7 -0.29 36 43
NFKB1 0.035 0.007 -10000 0 0 18 18
MAPK8 0.022 0.12 0.25 12 -0.3 28 40
actin cytoskeleton organization 0.034 0.11 0.24 22 -0.29 19 41
NF-kappa-B/RelA 0.042 0.087 0.26 1 -0.26 16 17
Calcineurin -0.009 0.13 0.24 2 -0.32 45 47
PI3K -0.031 0.085 -10000 0 -0.27 34 34
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.018 0.14 0.24 4 -0.38 49 53
SOS1 0 0 -10000 0 -10000 0 0
Bam32/HPK1 0.015 0.15 -10000 0 -0.62 8 8
DAPP1 -0.004 0.15 -10000 0 -0.7 8 8
cytokine secretion -0.015 0.088 0.25 4 -0.25 32 36
mol:DAG -0.026 0.13 0.23 4 -0.38 44 48
PLCG2 0.032 0.012 -10000 0 0 63 63
MAP2K1 -0.036 0.1 0.18 4 -0.3 46 50
B-cell antigen/BCR complex/FcgammaRIIB 0.016 0.074 -10000 0 -0.12 96 96
mol:PI-3-4-5-P3 -0.018 0.07 0.18 20 -0.21 16 36
ETS1 -0.029 0.11 0.21 5 -0.31 46 51
B-cell antigen/BCR complex/LYN/SYK/BLNK 0.034 0.091 -10000 0 -0.15 60 60
B-cell antigen/BCR complex/LYN -0.011 0.098 -10000 0 -0.3 38 38
MALT1 0.034 0.009 -10000 0 0 32 32
TRAF6 0.036 0.005 -10000 0 0 10 10
RAC1 0.031 0.12 0.26 14 -0.31 19 33
B-cell antigen/BCR complex/LYN/SYK 0.023 0.11 -10000 0 -0.28 33 33
CARD11 -0.027 0.13 0.22 4 -0.36 45 49
FCGR2B 0.021 0.018 -10000 0 0 222 222
PPP3CA 0.034 0.01 -10000 0 0 38 38
BCL10 0.035 0.007 -10000 0 0 20 20
IKK complex 0.003 0.043 0.12 5 -0.12 8 13
PTPRC 0.029 0.015 -10000 0 0 110 110
PDPK1 -0.015 0.056 0.15 20 -0.16 11 31
PPP3CB 0.025 0.017 -10000 0 0 157 157
PPP3CC 0.036 0.006 -10000 0 0 13 13
POU2F2 0.015 0.03 0.09 2 -0.087 16 18
EPHB forward signaling

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0.045 0.014 -10000 0 -10000 0 0
cell-cell adhesion 0.03 0.04 0.14 36 -10000 0 36
Ephrin B/EPHB2/RasGAP 0.058 0.09 -10000 0 -0.13 75 75
ITSN1 0.035 0.007 -10000 0 0 21 21
PIK3CA 0.031 0.013 -10000 0 0 80 80
SHC1 0.033 0.011 -10000 0 0 52 52
Ephrin B1/EPHB3 0.044 0.015 -10000 0 -10000 0 0
Ephrin B1/EPHB1 0.039 0.025 -10000 0 -0.12 6 6
HRAS/GDP 0.004 0.081 0.17 2 -0.22 40 42
Ephrin B/EPHB1/GRB7 0.067 0.075 -10000 0 -0.12 47 47
Endophilin/SYNJ1 -0.027 0.056 0.19 14 -0.18 2 16
KRAS 0.034 0.009 -10000 0 0 35 35
Ephrin B/EPHB1/Src 0.065 0.077 -10000 0 -0.12 53 53
endothelial cell migration 0.02 0.073 -10000 0 -0.14 63 63
GRB2 0.035 0.007 -10000 0 0 17 17
GRB7 0.036 0.006 -10000 0 0 14 14
PAK1 -0.028 0.061 0.19 18 -10000 0 18
HRAS 0.034 0.009 -10000 0 0 32 32
RRAS -0.026 0.056 0.2 10 -0.18 9 19
DNM1 0.035 0.008 -10000 0 0 26 26
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.019 0.065 0.18 20 -0.18 11 31
lamellipodium assembly -0.03 0.04 -10000 0 -0.14 36 36
Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.008 0.072 -10000 0 -0.29 14 14
PIK3R1 0.032 0.012 -10000 0 0 63 63
EPHB2 0.034 0.01 -10000 0 0 42 42
EPHB3 0.033 0.011 -10000 0 0 52 52
EPHB1 0.03 0.014 -10000 0 0 95 95
EPHB4 0.025 0.017 -10000 0 0 166 166
mol:GDP 0.019 0.12 0.2 101 -0.24 36 137
Ephrin B/EPHB2 0.051 0.068 -10000 0 -0.11 65 65
Ephrin B/EPHB3 0.05 0.068 -10000 0 -0.11 64 64
JNK cascade -0.005 0.07 0.23 23 -0.19 4 27
Ephrin B/EPHB1 0.051 0.066 -10000 0 -0.11 54 54
RAP1/GDP 0.028 0.12 0.2 108 -0.22 35 143
EFNB2 0.028 0.015 -10000 0 0 116 116
EFNB3 0.035 0.009 -10000 0 0 29 29
EFNB1 0.037 0 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 0.03 0.058 -10000 0 -0.11 52 52
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.036 0.005 -10000 0 0 11 11
CDC42/GTP 0.043 0.083 -10000 0 -0.19 34 34
Rap1/GTP -0.044 0.052 0.052 8 -0.2 22 30
axon guidance 0.044 0.014 -10000 0 -10000 0 0
MAPK3 -0.009 0.071 0.18 3 -0.27 16 19
MAPK1 -0.009 0.074 0.18 2 -0.28 19 21
Rac1/GDP -0.008 0.093 0.24 20 -0.24 32 52
actin cytoskeleton reorganization -0.039 0.06 -10000 0 -0.2 41 41
CDC42/GDP 0.036 0.13 0.22 114 -0.23 35 149
PI3K 0.024 0.076 -10000 0 -0.14 63 63
EFNA5 0.036 0.004 -10000 0 0 6 6
Ephrin B2/EPHB4 0.016 0.047 -10000 0 -0.11 46 46
Ephrin B/EPHB2/Intersectin/N-WASP 0.001 0.06 -10000 0 -0.3 6 6
CDC42 0.035 0.008 -10000 0 0 24 24
RAS family/GTP -0.052 0.06 -10000 0 -0.24 24 24
PTK2 -0.015 0.08 0.53 9 -0.2 15 24
MAP4K4 -0.005 0.071 0.23 23 -0.19 4 27
SRC 0.036 0.006 -10000 0 0 14 14
KALRN 0.035 0.008 -10000 0 0 23 23
Intersectin/N-WASP 0.032 0.033 -10000 0 -0.14 7 7
neuron projection morphogenesis 0.064 0.17 0.34 123 -0.22 14 137
MAP2K1 -0.001 0.071 0.2 1 -0.27 17 18
WASL 0.024 0.017 -10000 0 0 172 172
Ephrin B1/EPHB1-2/NCK1 0.082 0.038 -10000 0 -0.12 9 9
cell migration -0.015 0.087 0.22 1 -0.28 20 21
NRAS 0.032 0.012 -10000 0 0 63 63
SYNJ1 -0.027 0.057 0.19 14 -0.18 2 16
PXN 0.036 0.004 -10000 0 0 7 7
TF -0.022 0.051 0.19 6 -0.18 21 27
HRAS/GTP 0.034 0.079 -10000 0 -0.14 61 61
Ephrin B1/EPHB1-2 0.052 0.035 -10000 0 -0.11 6 6
cell adhesion mediated by integrin 0.019 0.046 0.15 4 -0.27 4 8
RAC1 0.024 0.017 -10000 0 0 173 173
mol:GTP 0.042 0.077 -10000 0 -0.13 62 62
RAC1-CDC42/GTP -0.03 0.046 -10000 0 -0.2 14 14
RASA1 0.034 0.009 -10000 0 0 32 32
RAC1-CDC42/GDP 0.011 0.095 0.25 18 -0.24 33 51
ruffle organization 0.074 0.17 0.31 141 -0.25 6 147
NCK1 0.035 0.008 -10000 0 0 27 27
receptor internalization -0.031 0.053 0.18 14 -0.18 2 16
Ephrin B/EPHB2/KALRN 0.064 0.079 -10000 0 -0.12 62 62
ROCK1 -0.01 0.045 0.18 17 -10000 0 17
RAS family/GDP -0.042 0.063 -10000 0 -0.21 42 42
Rac1/GTP -0.028 0.045 -10000 0 -0.2 13 13
Ephrin B/EPHB1/Src/Paxillin 0.009 0.065 -10000 0 -0.15 56 56
Regulation of nuclear SMAD2/3 signaling

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.019 0.038 -10000 0 -0.055 93 93
HSPA8 0.036 0.009 -10000 0 0 24 24
SMAD3/SMAD4/ER alpha 0.044 0.087 0.23 8 -0.15 30 38
AKT1 0.029 0.021 -10000 0 -0.029 39 39
GSC 0.002 0.028 0.1 13 -0.064 3 16
NKX2-5 0.033 0.017 0.07 8 -0.06 12 20
muscle cell differentiation -0.017 0.13 0.3 51 -10000 0 51
SMAD2-3/SMAD4/SP1 0.051 0.14 0.33 5 -0.24 52 57
SMAD4 0.022 0.054 0.14 1 -0.13 32 33
CBFB 0.035 0.006 -10000 0 0 16 16
SAP18 0.034 0.01 -10000 0 0 41 41
Cbp/p300/MSG1 0.011 0.086 -10000 0 -0.13 104 104
SMAD3/SMAD4/VDR 0.045 0.12 -10000 0 -0.2 34 34
MYC 0.029 0.014 -10000 0 -10000 0 0
CDKN2B -0.21 0.19 -10000 0 -0.57 18 18
AP1 -0.001 0.099 0.21 2 -0.23 50 52
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 -0.011 0.13 -10000 0 -0.36 39 39
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.002 0.081 -10000 0 -0.27 31 31
SP3 0.035 0.016 0.078 14 -0.023 24 38
CREB1 0.036 0.004 -10000 0 0 7 7
FOXH1 0.035 0.016 0.072 10 -0.06 12 22
SMAD3/SMAD4/GR 0.04 0.091 0.26 1 -0.15 38 39
GATA3 0.027 0.018 -10000 0 -10000 0 0
SKI/SIN3/HDAC complex/NCoR1 -0.003 0.091 -10000 0 -0.28 31 31
MEF2C/TIF2 -0.019 0.074 0.3 7 -0.23 15 22
endothelial cell migration 0.19 0.5 1.2 104 -10000 0 104
MAX 0.026 0.043 0.085 85 -0.053 89 174
RBBP7 0.036 0.005 -10000 0 0 8 8
RBBP4 0.033 0.012 -10000 0 0 56 56
RUNX2 0.037 0.002 -10000 0 0 1 1
RUNX3 0.034 0.009 -10000 0 0 34 34
RUNX1 0.036 0.005 -10000 0 0 10 10
CTBP1 0.035 0.008 -10000 0 0 26 26
NR3C1 0.027 0.043 0.086 84 -0.053 90 174
VDR 0.035 0.007 -10000 0 0 18 18
CDKN1A -0.11 0.36 0.39 1 -1.1 59 60
KAT2B -0.003 0.008 -10000 0 -0.024 11 11
SMAD2/SMAD2/SMAD4/FOXH1 0.049 0.077 0.2 2 -0.16 36 38
DCP1A 0.035 0.008 -10000 0 0 24 24
SKI 0.037 0.001 -10000 0 -10000 0 0
SERPINE1 -0.2 0.5 -10000 0 -1.2 104 104
SMAD3/SMAD4/ATF2 0.041 0.086 0.21 1 -0.15 49 50
SMAD3/SMAD4/ATF3 0.021 0.1 -10000 0 -0.17 81 81
SAP30 0.035 0.007 -10000 0 0 20 20
Cbp/p300/PIAS3 0.041 0.073 -10000 0 -0.094 91 91
JUN -0.014 0.097 0.18 10 -0.24 45 55
SMAD3/SMAD4/IRF7 0.044 0.09 -10000 0 -0.16 32 32
TFE3 0.016 0.059 0.11 8 -0.095 101 109
COL1A2 -0.045 0.21 -10000 0 -0.64 53 53
mesenchymal cell differentiation -0.041 0.086 0.15 50 -0.21 1 51
DLX1 0 0 -10000 0 -10000 0 0
TCF3 0.035 0.008 -10000 0 0 28 28
FOS 0.02 0.03 0.12 2 -0.045 46 48
SMAD3/SMAD4/Max 0.041 0.087 0.26 1 -0.16 22 23
Cbp/p300/SNIP1 0.044 0.056 -10000 0 -0.12 9 9
ZBTB17 0.035 0.006 -10000 0 -10000 0 0
LAMC1 -0.033 0.098 0.16 8 -0.29 43 51
TGIF2/HDAC complex/SMAD3/SMAD4 0.04 0.084 0.21 1 -0.14 48 49
IRF7 0.034 0.01 -10000 0 -10000 0 0
ESR1 0.037 0.039 0.12 67 -0.026 59 126
HNF4A 0.035 0.007 -10000 0 0 20 20
MEF2C -0.028 0.068 0.3 7 -0.23 19 26
SMAD2-3/SMAD4 0.043 0.095 0.24 1 -0.19 31 32
Cbp/p300/Src-1 0.031 0.075 -10000 0 -0.097 100 100
IGHV3OR16-13 0.005 0.056 -10000 0 -0.48 6 6
TGIF2/HDAC complex 0.035 0.008 -10000 0 0 28 28
CREBBP 0.022 0.034 -10000 0 -0.045 101 101
SKIL 0.036 0.006 -10000 0 0 13 13
HDAC1 0.035 0.007 -10000 0 0 21 21
HDAC2 0.032 0.013 -10000 0 0 67 67
SNIP1 0.037 0.007 -10000 0 0 12 12
GCN5L2 0.022 0.034 -10000 0 -0.045 100 100
SMAD3/SMAD4/TFE3 0.031 0.12 0.28 4 -0.22 57 61
MSG1/HSC70 0.009 0.079 -10000 0 -0.14 100 100
SMAD2 0.035 0.017 0.089 2 -0.048 11 13
SMAD3 0.019 0.058 0.14 2 -0.12 43 45
SMAD3/E2F4-5/DP1/p107/SMAD4 0.002 0.073 -10000 0 -0.2 34 34
SMAD2/SMAD2/SMAD4 -0.012 0.07 0.17 10 -0.2 40 50
NCOR1 0.035 0.008 -10000 0 0 26 26
NCOA2 0.036 0.006 -10000 0 0 12 12
NCOA1 0.033 0.011 -10000 0 0 50 50
MYOD/E2A 0.051 0.014 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1/MIZ-1 0.059 0.14 0.35 4 -0.23 47 51
IFNB1 -0.005 0.057 0.19 3 -0.2 2 5
SMAD3/SMAD4/MEF2C 0.027 0.092 0.27 3 -0.24 17 20
CITED1 0.026 0.017 -10000 0 0 151 151
SMAD2-3/SMAD4/ARC105 0.042 0.085 0.21 3 -0.17 31 34
RBL1 0 0 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB -0.007 0.1 -10000 0 -0.36 23 23
RUNX1-3/PEBPB2 0.066 0.023 -10000 0 -10000 0 0
SMAD7 -0.04 0.18 0.28 3 -0.43 59 62
MYC/MIZ-1 0.028 0.057 -10000 0 -0.14 47 47
SMAD3/SMAD4 -0.08 0.23 -10000 0 -0.47 111 111
IL10 -0.007 0.061 0.19 8 -0.18 3 11
PIASy/HDAC complex 0.028 0.031 0.072 8 -0.031 89 97
PIAS3 0.023 0.029 -10000 0 -0.031 107 107
CDK2 0.021 0.032 -10000 0 -0.03 129 129
IL5 -0.008 0.063 0.19 7 -0.19 3 10
CDK4 0.021 0.031 -10000 0 -0.021 156 156
PIAS4 0.028 0.031 0.072 8 -0.031 89 97
ATF3 0.028 0.016 -10000 0 0 125 125
SMAD3/SMAD4/SP1 0.03 0.14 0.28 6 -0.24 59 65
FOXG1 0.001 0.007 0.023 21 -10000 0 21
FOXO3 -0.009 0.008 -10000 0 -10000 0 0
FOXO1 -0.008 0.007 -10000 0 -10000 0 0
FOXO4 -0.008 0.007 -10000 0 -10000 0 0
heart looping -0.028 0.068 0.3 7 -0.22 19 26
CEBPB 0.032 0.013 -10000 0 -10000 0 0
SMAD3/SMAD4/DLX1 0.025 0.073 0.18 2 -0.14 52 54
MYOD1 0.036 0.004 -10000 0 0 7 7
SMAD3/SMAD4/HNF4 0.04 0.085 0.21 1 -0.14 48 49
SMAD3/SMAD4/GATA3 0.033 0.085 -10000 0 -0.16 23 23
SnoN/SIN3/HDAC complex/NCoR1 0.036 0.006 -10000 0 0 13 13
SMAD3/SMAD4/RUNX1-3/PEBPB2 0.069 0.093 -10000 0 -0.15 20 20
SMAD3/SMAD4/SP1-3 0.047 0.14 0.34 3 -0.23 60 63
MED15 0 0 -10000 0 -10000 0 0
SP1 0.014 0.075 0.12 18 -0.12 107 125
SIN3B 0.035 0.009 -10000 0 0 29 29
SIN3A 0 0.001 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 0.07 0.084 0.25 1 -0.17 27 28
ITGB5 -0.031 0.1 0.2 8 -0.25 41 49
TGIF/SIN3/HDAC complex/CtBP -0.009 0.096 -10000 0 -0.3 32 32
SMAD3/SMAD4/AR 0.041 0.085 0.21 1 -0.15 47 48
AR 0.035 0.007 -10000 0 0 22 22
negative regulation of cell growth -0.016 0.12 -10000 0 -0.3 59 59
SMAD3/SMAD4/MYOD 0.042 0.086 0.21 1 -0.15 50 51
E2F5 0.036 0.005 -10000 0 0 8 8
E2F4 0.036 0.006 -10000 0 0 12 12
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.062 0.097 0.24 1 -0.18 31 32
SMAD2-3/SMAD4/FOXO1-3a-4 -0.006 0.097 -10000 0 -0.32 27 27
TFDP1 0.033 0.011 -10000 0 0 53 53
SMAD3/SMAD4/AP1 0.024 0.12 0.26 1 -0.24 48 49
SMAD3/SMAD4/RUNX2 0.041 0.086 0.21 1 -0.15 50 51
TGIF2 0.035 0.008 -10000 0 0 28 28
TGIF1 0 0 -10000 0 -10000 0 0
ATF2 0.036 0.005 -10000 0 0 11 11
Sphingosine 1-phosphate (S1P) pathway

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.034 0.009 -10000 0 0 34 34
SPHK1 0.033 0.011 -10000 0 0 50 50
GNAI2 0.034 0.01 -10000 0 0 43 43
mol:S1P 0.018 0.015 -10000 0 -10000 0 0
GNAO1 0.03 0.014 -10000 0 0 87 87
mol:Sphinganine-1-P -0.012 0.032 0.092 42 -10000 0 42
growth factor activity 0 0 -10000 0 -10000 0 0
S1P/S1P2/G12/G13 0.028 0.046 -10000 0 -0.16 4 4
GNAI3 0.036 0.006 -10000 0 0 15 15
G12/G13 0.025 0.047 -10000 0 -0.14 28 28
S1PR3 0 0 -10000 0 -10000 0 0
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 0.033 0.01 -10000 0 0 45 45
S1P1/S1P 0.035 0.033 -10000 0 -10000 0 0
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
GNAI1 0.018 0.018 -10000 0 0 263 263
S1P/S1P5/G12 0.016 0.037 -10000 0 -0.16 4 4
S1P/S1P3/Gq 0.025 0.042 -10000 0 -0.26 7 7
S1P/S1P4/Gi -0.003 0.11 0.13 7 -0.22 74 81
GNAQ 0.034 0.009 -10000 0 0 31 31
GNAZ 0.031 0.013 -10000 0 0 81 81
GNA14 0.034 0.009 -10000 0 0 30 30
GNA15 0.033 0.012 -10000 0 0 57 57
GNA12 0.023 0.018 -10000 0 0 193 193
GNA13 0.035 0.007 -10000 0 0 19 19
GNA11 0.033 0.011 -10000 0 0 54 54
ABCC1 0.035 0.007 -10000 0 0 19 19
Noncanonical Wnt signaling pathway

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 0 0 -10000 0 -10000 0 0
GNB1/GNG2 0.003 0.099 -10000 0 -0.25 27 27
mol:DAG -0.012 0.09 0.18 4 -0.25 27 31
PLCG1 -0.013 0.092 0.18 4 -0.25 27 31
YES1 -0.016 0.084 -10000 0 -0.18 85 85
FZD3 0.029 0.015 -10000 0 0 110 110
FZD6 0.027 0.016 -10000 0 0 130 130
G protein 0.003 0.1 0.2 23 -0.27 25 48
MAP3K7 -0.036 0.074 0.14 6 -0.23 31 37
mol:Ca2+ -0.012 0.088 0.18 4 -0.24 27 31
mol:IP3 -0.012 0.09 0.18 4 -0.25 27 31
NLK -0.039 0.25 -10000 0 -0.78 52 52
GNB1 0.035 0.007 -10000 0 0 20 20
CAMK2A -0.031 0.078 0.16 5 -0.24 27 32
MAP3K7IP1 0.034 0.009 -10000 0 0 35 35
Noncanonical Wnts/FZD -0.006 0.089 -10000 0 -0.17 89 89
CSNK1A1 0.036 0.006 -10000 0 0 14 14
GNAS -0.014 0.08 -10000 0 -0.17 83 83
GO:0007205 -0.02 0.085 0.18 4 -0.25 27 31
WNT6 0.037 0.002 -10000 0 0 1 1
WNT4 0.035 0.007 -10000 0 0 18 18
NFAT1/CK1 alpha -0.005 0.098 0.22 5 -0.26 27 32
GNG2 0 0 -10000 0 -10000 0 0
WNT5A 0.029 0.015 -10000 0 0 99 99
WNT11 0.036 0.006 -10000 0 0 14 14
CDC42 -0.025 0.082 0.17 5 -0.27 21 26
Arf6 downstream pathway

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR -0.013 0.19 -10000 0 -0.8 24 24
regulation of axonogenesis 0.003 0.064 0.21 36 -10000 0 36
myoblast fusion -0.015 0.093 0.35 27 -10000 0 27
mol:GTP 0.015 0.065 -10000 0 -0.18 48 48
regulation of calcium-dependent cell-cell adhesion -0.026 0.073 0.15 62 -0.15 1 63
ARF1/GTP 0.035 0.061 -10000 0 -0.14 50 50
mol:GM1 0.003 0.047 -10000 0 -0.13 49 49
mol:Choline -0.015 0.041 0.085 3 -0.13 40 43
lamellipodium assembly -0.009 0.1 -10000 0 -0.37 33 33
MAPK3 0.012 0.081 0.14 37 -0.23 37 74
ARF6/GTP/NME1/Tiam1 0.027 0.074 0.15 1 -0.15 62 63
ARF1 0.035 0.008 -10000 0 0 24 24
ARF6/GDP 0.015 0.093 -10000 0 -0.35 27 27
ARF1/GDP 0.013 0.1 -10000 0 -0.28 45 45
ARF6 0.039 0.042 -10000 0 -0.13 25 25
RAB11A 0.035 0.007 -10000 0 0 18 18
TIAM1 0.029 0.022 -10000 0 -0.044 32 32
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.012 0.082 0.14 36 -0.24 36 72
actin filament bundle formation -0.019 0.11 0.28 49 -10000 0 49
KALRN 0.006 0.069 -10000 0 -0.26 28 28
RAB11FIP3/RAB11A 0.047 0.034 -10000 0 -0.16 12 12
RhoA/GDP 0.02 0.11 -10000 0 -0.28 49 49
NME1 -0.001 0.008 -10000 0 -0.03 25 25
Rac1/GDP 0.013 0.089 -10000 0 -0.28 34 34
substrate adhesion-dependent cell spreading 0.015 0.065 -10000 0 -0.18 48 48
cortical actin cytoskeleton organization -0.009 0.1 -10000 0 -0.37 33 33
RAC1 0.024 0.017 -10000 0 0 173 173
liver development 0.015 0.065 -10000 0 -0.18 48 48
ARF6/GTP 0.015 0.065 -10000 0 -0.18 48 48
RhoA/GTP 0.034 0.063 -10000 0 -0.14 52 52
mol:GDP -0.005 0.1 0.17 2 -0.3 46 48
ARF6/GTP/RAB11FIP3/RAB11A 0.051 0.068 -10000 0 -0.13 58 58
RHOA 0.035 0.007 -10000 0 0 18 18
PLD1 0.012 0.051 -10000 0 -0.14 45 45
RAB11FIP3 0.036 0.006 -10000 0 0 15 15
tube morphogenesis -0.009 0.1 -10000 0 -0.37 33 33
ruffle organization -0.003 0.064 -10000 0 -0.21 36 36
regulation of epithelial cell migration 0.015 0.065 -10000 0 -0.18 48 48
PLD2 0.012 0.052 -10000 0 -0.14 47 47
PIP5K1A -0.003 0.064 -10000 0 -0.21 36 36
mol:Phosphatidic acid -0.015 0.041 0.085 3 -0.13 40 43
Rac1/GTP -0.009 0.1 -10000 0 -0.37 33 33
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.042 0.01 -10000 0 -0.042 1 1
NFATC2 0.014 0.15 0.27 6 -0.35 43 49
NFATC3 0.017 0.13 0.26 25 -0.24 71 96
CD40LG -0.016 0.33 0.48 44 -0.71 64 108
ITCH 0.035 0.046 0.19 8 -10000 0 8
CBLB 0.036 0.048 0.19 11 -10000 0 11
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.051 0.26 0.38 13 -0.62 56 69
JUNB 0.031 0.014 -10000 0 0 83 83
CaM/Ca2+/Calcineurin A alpha-beta B1 0.033 0.027 -10000 0 -0.13 6 6
T cell anergy 0.016 0.067 0.26 10 -0.25 1 11
TLE4 0.01 0.11 -10000 0 -0.31 22 22
Jun/NFAT1-c-4/p21SNFT -0.017 0.33 0.44 5 -0.73 70 75
AP-1/NFAT1-c-4 -0.033 0.35 -10000 0 -0.79 64 64
IKZF1 0.006 0.099 0.17 6 -0.24 39 45
T-helper 2 cell differentiation -0.085 0.23 -10000 0 -0.62 45 45
AP-1/NFAT1 0.017 0.14 0.28 17 -0.29 45 62
CALM1 0.046 0.024 0.13 2 -10000 0 2
EGR2 -0.08 0.41 0.51 10 -0.98 74 84
EGR3 -0.059 0.42 0.49 16 -0.99 70 86
NFAT1/FOXP3 0.038 0.12 0.25 4 -0.26 36 40
EGR1 0.029 0.015 0.07 1 -10000 0 1
JUN 0.032 0.041 0.11 34 -0.054 9 43
EGR4 0.037 0.004 0.07 1 -10000 0 1
mol:Ca2+ 0.005 0.003 -10000 0 -10000 0 0
GBP3 0.006 0.099 0.17 6 -0.24 39 45
FOSL1 0.033 0.011 -10000 0 0 55 55
NFAT1-c-4/MAF/IRF4 0.009 0.33 -10000 0 -0.72 74 74
DGKA 0.011 0.1 0.21 1 -0.28 27 28
CREM 0.026 0.016 -10000 0 0 142 142
NFAT1-c-4/PPARG -0.009 0.33 -10000 0 -0.73 73 73
CTLA4 0.009 0.092 0.18 1 -0.26 22 23
NFAT1-c-4 (dimer)/EGR1 -0.03 0.34 -10000 0 -0.77 74 74
NFAT1-c-4 (dimer)/EGR4 -0.001 0.33 -10000 0 -0.74 73 73
FOS 0.023 0.038 0.11 19 -0.05 7 26
IFNG -0.009 0.13 -10000 0 -0.45 10 10
T cell activation -0.013 0.21 -10000 0 -0.58 20 20
MAF 0.034 0.009 -10000 0 0 35 35
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.008 0.28 0.6 72 -0.45 22 94
TNF -0.04 0.31 0.4 9 -0.7 74 83
FASLG -0.1 0.46 -10000 0 -1.1 74 74
TBX21 0.04 0.006 0.11 3 -10000 0 3
BATF3 0 0 -10000 0 -10000 0 0
PRKCQ 0.026 0.018 -10000 0 -10000 0 0
PTPN1 0.008 0.12 0.42 1 -0.37 23 24
NFAT1-c-4/ICER1 -0.033 0.32 -10000 0 -0.73 73 73
GATA3 0.027 0.018 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0.004 0.14 -10000 0 -0.44 10 10
IL2RA -0.06 0.25 0.35 6 -0.6 61 67
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 0.007 0.11 -10000 0 -0.36 24 24
E2F1 0.037 0.051 0.11 2 -0.25 13 15
PPARG 0.035 0.008 -10000 0 -10000 0 0
SLC3A2 0.008 0.12 0.24 2 -0.38 26 28
IRF4 0.037 0.002 -10000 0 0 1 1
PTGS2 -0.071 0.28 0.43 3 -0.71 63 66
CSF2 -0.016 0.33 0.48 44 -0.71 65 109
JunB/Fra1/NFAT1-c-4 -0.014 0.31 -10000 0 -0.72 70 70
IL4 -0.089 0.24 -10000 0 -0.64 45 45
IL5 -0.016 0.33 0.48 44 -0.71 65 109
IL2 -0.013 0.22 -10000 0 -0.59 19 19
IL3 0.007 0.088 -10000 0 -0.58 7 7
RNF128 0.014 0.022 0.17 1 -10000 0 1
NFATC1 -0.008 0.28 0.45 22 -0.6 72 94
CDK4 -0.011 0.27 0.52 35 -1 14 49
PTPRK -0.001 0.14 -10000 0 -0.43 34 34
IL8 -0.1 0.29 0.46 7 -0.75 62 69
POU2F1 0.039 0.008 -10000 0 -10000 0 0
E-cadherin signaling in keratinocytes

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation -0.019 0.11 0.15 11 -0.36 29 40
adherens junction organization -0.001 0.076 0.16 3 -0.31 19 22
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.026 0.11 0.19 49 -0.3 21 70
FMN1 0.008 0.063 0.15 4 -0.27 15 19
mol:IP3 -0.008 0.079 0.14 5 -0.25 32 37
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.013 0.067 0.16 4 -0.28 15 19
CTNNB1 0.035 0.006 -10000 0 0 15 15
AKT1 -0.006 0.088 0.14 2 -0.28 32 34
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.027 0.067 -10000 0 -0.39 6 6
CTNND1 0.035 0.009 -10000 0 0 32 32
mol:PI-4-5-P2 0.003 0.067 0.15 7 -0.27 17 24
VASP 0.002 0.062 0.15 3 -0.27 15 18
ZYX 0.006 0.057 0.14 4 -0.32 9 13
JUB 0.008 0.063 0.15 4 -0.27 15 19
EGFR(dimer) 0.001 0.065 -10000 0 -0.3 14 14
E-cadherin/beta catenin-gamma catenin 0.064 0.029 -10000 0 -0.12 3 3
mol:PI-3-4-5-P3 0.02 0.093 -10000 0 -0.29 25 25
PIK3CA 0.03 0.015 -10000 0 -0.002 84 84
PI3K 0.02 0.095 -10000 0 -0.29 25 25
FYN -0.042 0.13 0.25 1 -0.31 76 77
mol:Ca2+ -0.008 0.078 0.14 5 -0.24 32 37
JUP 0.033 0.011 0.056 1 0 51 52
PIK3R1 0.031 0.015 -10000 0 -0.004 72 72
mol:DAG -0.008 0.079 0.14 5 -0.25 32 37
CDH1 0.034 0.01 -10000 0 0 38 38
RhoA/GDP 0.062 0.13 0.19 99 -0.29 22 121
establishment of polarity of embryonic epithelium 0.002 0.062 0.15 4 -0.27 15 19
SRC 0.036 0.006 -10000 0 0 14 14
RAC1 0.024 0.017 -10000 0 0 173 173
RHOA 0.035 0.007 -10000 0 0 18 18
EGFR 0.009 0.016 -10000 0 0 381 381
CASR -0.024 0.075 0.14 18 -0.27 25 43
RhoA/GTP 0.009 0.086 0.15 1 -0.26 27 28
AKT2 -0.005 0.08 0.14 2 -0.28 25 27
actin cable formation -0.002 0.061 0.15 3 -0.26 16 19
apoptosis 0.01 0.098 0.33 29 -0.17 12 41
CTNNA1 0.035 0.008 -10000 0 -0.001 21 21
mol:GDP -0.021 0.074 0.19 4 -0.3 21 25
PIP5K1A 0.003 0.067 0.15 7 -0.27 17 24
PLCG1 -0.008 0.081 0.14 5 -0.26 32 37
Rac1/GTP -0.004 0.069 -10000 0 -0.32 13 13
homophilic cell adhesion -0.001 0.003 -10000 0 -10000 0 0
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.033 0.01 -10000 0 0 45 45
VLDLR 0.027 0.016 -10000 0 0 135 135
LRPAP1 0.035 0.007 -10000 0 0 18 18
NUDC 0.035 0.008 -10000 0 0 27 27
RELN/LRP8 0.039 0.044 -10000 0 -0.13 11 11
CaM/Ca2+ 0.021 0.026 -10000 0 -0.13 13 13
KATNA1 0.033 0.01 -10000 0 0 44 44
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 0.037 0.1 0.19 139 -0.21 6 145
IQGAP1/CaM 0.031 0.058 -10000 0 -0.15 44 44
DAB1 0.036 0.005 -10000 0 0 9 9
IQGAP1 0.033 0.011 -10000 0 0 51 51
PLA2G7 0.033 0.011 -10000 0 0 53 53
CALM1 0.033 0.011 -10000 0 0 54 54
DYNLT1 0.033 0.01 -10000 0 0 44 44
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 0.045 0.036 -10000 0 -0.15 14 14
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 0 0 -10000 0 -10000 0 0
CDK5R1 0.035 0.008 -10000 0 0 24 24
LIS1/Poliovirus Protein 3A -0.023 0.028 -10000 0 -0.14 24 24
CDK5R2 0.035 0.006 -10000 0 0 16 16
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 0.031 0.048 -10000 0 -0.12 19 19
YWHAE 0.035 0.008 -10000 0 0 27 27
NDEL1/14-3-3 E 0.064 0.17 0.32 136 -0.27 17 153
MAP1B -0.014 0.067 -10000 0 -0.2 51 51
RAC1 -0.003 0.051 -10000 0 -0.26 12 12
p35/CDK5 -0.025 0.056 0.2 7 -0.21 12 19
RELN 0.023 0.018 -10000 0 0 188 188
PAFAH/LIS1 0.022 0.039 -10000 0 -0.15 21 21
LIS1/CLIP170 -0.023 0.028 -10000 0 -0.14 24 24
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.034 0.078 0.13 18 -0.27 26 44
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.014 0.087 0.17 1 -0.23 52 53
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 0.056 0.16 0.31 123 -0.27 15 138
LIS1/IQGAP1 0.014 0.058 -10000 0 -0.15 50 50
RHOA -0.005 0.065 -10000 0 -0.33 13 13
PAFAH1B1 -0.021 0.007 -10000 0 -10000 0 0
PAFAH1B3 0.031 0.013 -10000 0 0 76 76
PAFAH1B2 0.036 0.004 -10000 0 0 7 7
MAP1B/LIS1/Dynein heavy chain 0.007 0.078 -10000 0 -0.2 54 54
NDEL1/Katanin 60/Dynein heavy chain 0.082 0.15 0.33 112 -0.26 22 134
LRP8 0.034 0.009 -10000 0 0 35 35
NDEL1/Katanin 60 0.056 0.16 0.31 126 -0.27 18 144
P39/CDK5 -0.025 0.056 0.2 7 -0.21 12 19
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.021 0.052 -10000 0 -0.19 26 26
CDK5 -0.014 0.045 0.19 8 -0.22 6 14
PPP2R5D 0.036 0.004 -10000 0 0 5 5
LIS1/CLIP170/Dynein Complex/Dynactin Complex -0.019 0.023 -10000 0 -0.12 24 24
CSNK2A1 0.034 0.009 -10000 0 0 31 31
RELN/VLDLR/DAB1/LIS1 0.033 0.059 0.18 3 -0.13 33 36
RELN/VLDLR 0.044 0.06 -10000 0 -0.12 26 26
CDC42 -0.002 0.045 -10000 0 -0.21 12 12
Reelin signaling pathway

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.028 0.041 -10000 0 -0.14 18 18
VLDLR 0.027 0.016 -10000 0 0 135 135
CRKL 0.035 0.009 -10000 0 0 29 29
LRPAP1 0.035 0.007 -10000 0 0 18 18
FYN 0.03 0.014 -10000 0 0 90 90
ITGA3 0.033 0.011 -10000 0 0 56 56
RELN/VLDLR/Fyn 0.018 0.06 -10000 0 -0.13 51 51
MAPK8IP1/MKK7/MAP3K11/JNK1 0.068 0.06 -10000 0 -0.11 4 4
AKT1 -0.014 0.069 -10000 0 -0.2 49 49
MAP2K7 0.035 0.008 -10000 0 0 24 24
RAPGEF1 0.035 0.007 -10000 0 0 19 19
DAB1 0.036 0.005 -10000 0 0 9 9
RELN/LRP8/DAB1 0.041 0.036 -10000 0 -0.11 3 3
LRPAP1/LRP8 0.045 0.036 -10000 0 -0.15 14 14
RELN/LRP8/DAB1/Fyn 0.041 0.059 -10000 0 -0.12 33 33
DAB1/alpha3/beta1 Integrin 0.029 0.058 -10000 0 -0.19 1 1
long-term memory 0.042 0.064 -10000 0 -0.12 31 31
DAB1/LIS1 0.048 0.072 -10000 0 -0.13 30 30
DAB1/CRLK/C3G 0.038 0.058 -10000 0 -0.12 23 23
PIK3CA 0.031 0.013 -10000 0 0 80 80
DAB1/NCK2 0.049 0.072 -10000 0 -0.13 28 28
ARHGEF2 0.035 0.007 -10000 0 0 20 20
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A 0.035 0.006 -10000 0 0 16 16
CDK5R1 0.035 0.008 -10000 0 0 24 24
RELN 0.023 0.018 -10000 0 0 188 188
PIK3R1 0.032 0.012 -10000 0 0 63 63
RELN/LRP8/Fyn 0.029 0.056 -10000 0 -0.13 34 34
GRIN2A/RELN/LRP8/DAB1/Fyn 0.051 0.071 -10000 0 -0.12 33 33
MAPK8 0.027 0.016 -10000 0 0 138 138
RELN/VLDLR/DAB1 0.03 0.044 -10000 0 -0.11 19 19
ITGB1 0.027 0.016 -10000 0 0 138 138
MAP1B 0.023 0.083 0.16 107 -0.21 3 110
RELN/LRP8 0.039 0.044 -10000 0 -0.13 11 11
GRIN2B/RELN/LRP8/DAB1/Fyn 0.051 0.07 -10000 0 -0.12 31 31
PI3K 0.019 0.075 -10000 0 -0.16 73 73
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin 0.034 0.027 -10000 0 -0.14 1 1
RAP1A 0.032 0.11 0.25 37 -10000 0 37
PAFAH1B1 0.035 0.008 -10000 0 0 25 25
MAPK8IP1 0.035 0.008 -10000 0 0 24 24
CRLK/C3G 0.05 0.015 -10000 0 -10000 0 0
GRIN2B 0.035 0.007 -10000 0 0 22 22
NCK2 0.035 0.007 -10000 0 0 17 17
neuron differentiation 0.009 0.064 -10000 0 -0.22 14 14
neuron adhesion 0.033 0.11 0.25 42 -10000 0 42
LRP8 0.034 0.009 -10000 0 0 35 35
GSK3B -0.009 0.079 0.18 1 -0.31 17 18
RELN/VLDLR/DAB1/Fyn 0.031 0.064 -10000 0 -0.11 51 51
MAP3K11 0.036 0.005 -10000 0 0 10 10
RELN/VLDLR/DAB1/P13K -0.008 0.074 -10000 0 -0.19 55 55
CDK5 0.023 0.018 -10000 0 0 192 192
MAPT -0.013 0.067 0.72 1 -10000 0 1
neuron migration 0 0.12 0.2 74 -0.28 32 106
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 0.009 0.064 -10000 0 -0.22 14 14
RELN/VLDLR 0.044 0.06 -10000 0 -0.12 26 26
Paxillin-dependent events mediated by a4b1

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.035 0.009 -10000 0 0 29 29
Rac1/GDP 0.024 0.021 -10000 0 -0.025 10 10
DOCK1 0.024 0.017 -10000 0 0 175 175
ITGA4 0.036 0.006 -10000 0 0 13 13
RAC1 0.024 0.017 -10000 0 0 173 173
alpha4/beta7 Integrin 0.052 0.011 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.035 0.008 -10000 0 0 23 23
alpha4/beta1 Integrin 0.051 0.034 -10000 0 -10000 0 0
alpha4/beta7 Integrin/Paxillin 0.052 0.017 -10000 0 -10000 0 0
lamellipodium assembly -0.046 0.14 -10000 0 -0.36 73 73
PIK3CA 0.031 0.013 -10000 0 0 80 80
PI3K 0.019 0.075 -10000 0 -0.16 73 73
ARF6 0.035 0.008 -10000 0 0 27 27
TLN1 0.029 0.015 -10000 0 0 102 102
PXN -0.021 0.01 0.092 3 -10000 0 3
PIK3R1 0.032 0.012 -10000 0 0 63 63
ARF6/GTP 0.049 0.048 -10000 0 -0.11 1 1
cell adhesion 0.049 0.047 -10000 0 -0.11 13 13
CRKL/CBL 0.051 0.014 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin 0.039 0.026 -10000 0 -10000 0 0
ITGB1 0.027 0.016 -10000 0 0 138 138
ITGB7 0.036 0.005 -10000 0 0 11 11
ARF6/GDP 0.035 0.015 -10000 0 -0.025 14 14
alpha4/beta1 Integrin/Paxillin/VCAM1 0.016 0.079 -10000 0 -0.11 116 116
p130Cas/Crk/Dock1 0.028 0.035 -10000 0 -0.11 17 17
VCAM1 0.022 0.018 -10000 0 0 196 196
alpha4/beta1 Integrin/Paxillin/Talin 0.051 0.048 -10000 0 -0.12 13 13
alpha4/beta1 Integrin/Paxillin/GIT1 0.059 0.04 -10000 0 -10000 0 0
BCAR1 0 0 -10000 0 -10000 0 0
mol:GDP -0.057 0.039 -10000 0 -10000 0 0
CBL 0.036 0.004 -10000 0 0 7 7
PRKACA 0.035 0.008 -10000 0 0 25 25
GIT1 0.036 0.003 -10000 0 0 4 4
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.051 0.048 -10000 0 -0.12 13 13
Rac1/GTP -0.052 0.16 -10000 0 -0.4 73 73
BMP receptor signaling

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS 0.063 0.064 -9999 0 -0.12 12 12
SMAD6-7/SMURF1 0.044 0.038 -9999 0 -0.12 2 2
NOG 0 0 -9999 0 -10000 0 0
SMAD9 -0.024 0.15 -9999 0 -0.44 54 54
SMAD4 0.032 0.012 -9999 0 0 58 58
SMAD5 -0.029 0.098 -9999 0 -0.3 45 45
BMP7/USAG1 0.033 0.027 -9999 0 -10000 0 0
SMAD5/SKI -0.021 0.11 -9999 0 -0.3 45 45
SMAD1 -0.031 0.15 -9999 0 -0.4 50 50
BMP2 0.029 0.015 -9999 0 0 107 107
SMAD1/SMAD1/SMAD4 -0.01 0.13 -9999 0 -0.36 42 42
BMPR1A 0.025 0.017 -9999 0 0 167 167
BMPR1B 0.036 0.006 -9999 0 0 14 14
BMPR1A-1B/BAMBI 0.02 0.06 -9999 0 -0.13 50 50
AHSG 0.035 0.009 -9999 0 0 29 29
CER1 0.031 0.013 -9999 0 0 71 71
BMP2-4/CER1 0.039 0.055 -9999 0 -0.12 35 35
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.01 0.078 -9999 0 -0.21 42 42
BMP2-4 (homodimer) 0.029 0.051 -9999 0 -0.14 35 35
RGMB 0 0 -9999 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B 0.058 0.052 -9999 0 -0.12 12 12
RGMA 0 0 -9999 0 -10000 0 0
SMURF1 0.025 0.017 -9999 0 0 167 167
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.021 0.07 -9999 0 -0.17 58 58
BMP2-4/USAG1 0.033 0.046 -9999 0 -0.12 16 16
SMAD6/SMURF1/SMAD5 -0.012 0.09 -9999 0 -0.29 34 34
SOSTDC1 0.023 0.018 -9999 0 0 184 184
BMP7/BMPR2/BMPR1A-1B 0.058 0.053 -9999 0 -0.12 14 14
SKI 0.037 0 -9999 0 -10000 0 0
BMP6 (homodimer) 0.035 0.008 -9999 0 0 24 24
HFE2 0 0 -9999 0 -10000 0 0
ZFYVE16 0.034 0.009 -9999 0 0 35 35
MAP3K7 0.034 0.01 -9999 0 0 41 41
BMP2-4/CHRD 0.043 0.054 -9999 0 -0.12 34 34
SMAD5/SMAD5/SMAD4 -0.022 0.11 -9999 0 -0.31 43 43
MAPK1 0.033 0.01 -9999 0 0 45 45
TAK1/TAB family 0.019 0.083 -9999 0 -0.2 19 19
BMP7 (homodimer) 0.034 0.01 -9999 0 0 39 39
NUP214 0.035 0.007 -9999 0 0 18 18
BMP6/FETUA 0.049 0.016 -9999 0 -10000 0 0
SMAD1/SKI -0.015 0.15 -9999 0 -0.38 52 52
SMAD6 0.036 0.005 -9999 0 0 11 11
CTDSP2 0.033 0.012 -9999 0 0 57 57
BMP2-4/FETUA 0.042 0.055 -9999 0 -0.12 35 35
MAP3K7IP1 0.034 0.009 -9999 0 0 35 35
GREM1 0.032 0.012 -9999 0 0 64 64
BMPR2 (homodimer) 0.036 0.006 -9999 0 0 12 12
GADD34/PP1CA 0.052 0.053 -9999 0 -0.13 31 31
BMPR1A-1B (homodimer) 0.034 0.032 -9999 0 -0.14 6 6
CHRDL1 0 0 -9999 0 -10000 0 0
ENDOFIN/SMAD1 -0.018 0.15 -9999 0 -0.39 53 53
SMAD6-7/SMURF1/SMAD1 0.004 0.14 -9999 0 -0.38 42 42
SMAD6/SMURF1 0.025 0.017 -9999 0 0 167 167
BAMBI 0.018 0.018 -9999 0 0 255 255
SMURF2 0.035 0.007 -9999 0 0 20 20
BMP2-4/CHRDL1 0.028 0.043 -9999 0 -0.11 35 35
BMP2-4/GREM1 0.039 0.054 -9999 0 -0.12 33 33
SMAD7 0.033 0.01 -9999 0 0 44 44
SMAD8A/SMAD8A/SMAD4 -0.012 0.15 -9999 0 -0.41 58 58
SMAD1/SMAD6 -0.015 0.14 -9999 0 -0.38 43 43
TAK1/SMAD6 0.032 0.034 -9999 0 -0.14 8 8
BMP7 0.034 0.01 -9999 0 0 39 39
BMP6 0.035 0.008 -9999 0 0 24 24
MAP3K7IP2 0.033 0.011 -9999 0 0 46 46
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.003 0.055 -9999 0 -0.22 16 16
PPM1A 0.034 0.009 -9999 0 0 30 30
SMAD1/SMURF2 -0.017 0.15 -9999 0 -0.39 51 51
SMAD7/SMURF1 0.033 0.029 -9999 0 -0.14 2 2
CTDSPL 0.036 0.006 -9999 0 0 12 12
PPP1CA 0.035 0.007 -9999 0 0 20 20
XIAP 0 0 -9999 0 -10000 0 0
CTDSP1 0.035 0.006 -9999 0 0 16 16
PPP1R15A 0.033 0.011 -9999 0 0 55 55
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.016 0.072 -9999 0 -0.17 55 55
CHRD 0.035 0.007 -9999 0 0 22 22
BMPR2 0.036 0.006 -9999 0 0 12 12
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.02 0.071 -9999 0 -0.18 53 53
BMP4 0.033 0.011 -9999 0 0 49 49
FST 0.033 0.011 -9999 0 0 48 48
BMP2-4/NOG 0.028 0.043 -9999 0 -0.11 35 35
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 0.05 0.061 -9999 0 -0.11 10 10
Class I PI3K signaling events

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP -0.023 0.053 0.17 14 -0.22 9 23
DAPP1 -0.027 0.12 -10000 0 -0.3 66 66
Src family/SYK family/BLNK-LAT/BTK-ITK -0.048 0.19 0.24 3 -0.45 68 71
mol:DAG -0.015 0.087 0.2 13 -0.2 47 60
HRAS 0.034 0.02 0.068 1 -0.015 59 60
RAP1A 0.038 0.013 0.063 4 -0.017 20 24
ARF5/GDP -0.002 0.095 -10000 0 -0.3 33 33
PLCG2 0.032 0.012 -10000 0 0 63 63
PLCG1 0.035 0.007 -10000 0 0 19 19
ARF5 0.024 0.017 -10000 0 0 175 175
mol:GTP -0.025 0.052 0.16 16 -0.2 9 25
ARF1/GTP -0.02 0.045 0.12 14 -0.2 11 25
RHOA 0.035 0.007 -10000 0 0 18 18
YES1 0.034 0.01 -10000 0 0 41 41
RAP1A/GTP -0.025 0.051 0.16 15 -0.19 9 24
ADAP1 -0.026 0.046 0.14 13 -0.19 9 22
ARAP3 -0.025 0.051 0.16 16 -0.19 9 25
INPPL1 0.036 0.006 -10000 0 0 12 12
PREX1 0 0 -10000 0 -10000 0 0
ARHGEF6 0.033 0.011 -10000 0 0 48 48
ARHGEF7 0.032 0.012 -10000 0 0 59 59
ARF1 0.035 0.008 -10000 0 0 24 24
NRAS 0.034 0.018 0.068 1 -0.005 75 76
FYN 0.03 0.014 -10000 0 0 90 90
ARF6 0.035 0.008 -10000 0 0 27 27
FGR 0.033 0.011 -10000 0 0 54 54
mol:Ca2+ 0.003 0.058 0.15 29 -0.12 17 46
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.033 0.011 -10000 0 0 46 46
ZAP70 0.036 0.002 -10000 0 0 2 2
mol:IP3 -0.009 0.068 0.18 26 -0.16 19 45
LYN 0.031 0.013 -10000 0 0 74 74
ARF1/GDP 0.007 0.11 -10000 0 -0.33 36 36
RhoA/GDP 0.023 0.089 0.18 12 -0.21 30 42
PDK1/Src/Hsp90 0.047 0.01 -10000 0 -10000 0 0
BLNK 0.019 0.018 -10000 0 0 243 243
actin cytoskeleton reorganization 0.007 0.1 0.2 21 -0.29 25 46
SRC 0.036 0.006 -10000 0 0 14 14
PLEKHA2 -0.012 0.024 0.085 29 -10000 0 29
RAC1 0.024 0.017 -10000 0 0 173 173
PTEN 0.026 0.022 -10000 0 -0.035 16 16
HSP90AA1 0 0 -10000 0 -10000 0 0
ARF6/GTP -0.028 0.052 0.16 15 -0.2 9 24
RhoA/GTP -0.028 0.058 0.18 17 -0.21 10 27
Src family/SYK family/BLNK-LAT -0.053 0.16 -10000 0 -0.35 86 86
BLK 0.035 0.007 -10000 0 0 17 17
PDPK1 0.036 0.004 -10000 0 0 7 7
CYTH1 -0.026 0.046 0.14 13 -0.19 9 22
HCK 0.027 0.016 -10000 0 0 128 128
CYTH3 -0.026 0.046 0.14 13 -0.19 9 22
CYTH2 -0.026 0.046 0.14 13 -0.19 9 22
KRAS 0.034 0.021 0.075 2 -0.032 31 33
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 -0.003 0.031 0.21 3 -0.16 1 4
SGK1 0 0.03 0.21 2 -0.15 2 4
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP -0.008 0.11 0.14 3 -0.33 37 40
SOS1 0 0 -10000 0 -10000 0 0
SYK 0.031 0.013 -10000 0 0 76 76
ARF6/GDP -0.028 0.066 0.18 13 -0.22 26 39
mol:PI-3-4-5-P3 -0.026 0.049 0.15 13 -0.2 9 22
ARAP3/RAP1A/GTP -0.025 0.051 0.16 15 -0.2 9 24
VAV1 0.034 0.009 -10000 0 0 35 35
mol:PI-3-4-P2 -0.011 0.002 -10000 0 -10000 0 0
RAS family/GTP/PI3K Class I 0.062 0.092 0.21 102 -0.14 42 144
PLEKHA1 -0.008 0.022 0.085 23 -10000 0 23
Rac1/GDP -0.002 0.098 -10000 0 -0.3 34 34
LAT 0.036 0.005 -10000 0 0 10 10
Rac1/GTP -0.005 0.15 -10000 0 -0.42 41 41
ITK -0.029 0.049 0.15 14 -0.19 9 23
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.026 0.11 0.23 11 -0.27 54 65
LCK 0.035 0.007 -10000 0 0 17 17
BTK -0.027 0.052 0.15 17 -0.19 9 26
IL12-mediated signaling events

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 0.041 0.087 0.22 29 -0.18 17 46
TBX21 0.067 0.2 0.57 6 -0.58 2 8
B2M 0.035 0.008 -10000 0 0 27 27
TYK2 0.036 0.039 0.12 13 -0.054 9 22
IL12RB1 0.037 0.04 0.12 16 -0.054 12 28
GADD45B 0.058 0.29 0.54 13 -0.99 24 37
IL12RB2 0.04 0.04 0.12 19 -0.052 22 41
GADD45G 0.089 0.18 0.52 11 -0.54 3 14
natural killer cell activation 0.012 0.024 0.055 73 -0.036 9 82
RELB 0.034 0.009 -10000 0 0 32 32
RELA 0.036 0.005 -10000 0 0 9 9
IL18 0.034 0.022 0.088 2 -0.043 17 19
IL2RA 0.024 0.017 -10000 0 0 172 172
IFNG 0.034 0.009 -10000 0 0 30 30
STAT3 (dimer) 0.072 0.22 0.45 26 -0.54 21 47
HLA-DRB5 -0.001 0.009 -10000 0 -0.023 42 42
FASLG 0.071 0.2 0.53 10 -0.54 5 15
NF kappa B2 p52/RelB 0.05 0.18 0.43 11 -0.46 15 26
CD4 0.025 0.026 -10000 0 -0.017 127 127
SOCS1 0.036 0.005 -10000 0 0 8 8
EntrezGene:6955 -0.001 0.01 -10000 0 -0.025 56 56
CD3D 0.025 0.028 -10000 0 -0.025 108 108
CD3E 0.028 0.027 -10000 0 -0.035 76 76
CD3G 0.027 0.028 -10000 0 -0.042 67 67
IL12Rbeta2/JAK2 0.055 0.059 0.18 18 -10000 0 18
CCL3 0.07 0.2 0.45 26 -0.47 15 41
CCL4 0.039 0.33 0.56 16 -1 31 47
HLA-A 0.036 0.006 -10000 0 0 13 13
IL18/IL18R 0.094 0.061 0.21 26 -0.11 15 41
NOS2 0.072 0.19 0.43 32 -0.42 17 49
IL12/IL12R/TYK2/JAK2/SPHK2 0.038 0.086 0.22 26 -0.18 18 44
IL1R1 0.069 0.2 0.58 8 -0.56 3 11
IL4 0.004 0.048 -10000 0 -0.073 81 81
JAK2 0.033 0.038 0.11 12 -0.051 23 35
EntrezGene:6957 -0.001 0.009 -10000 0 -0.023 42 42
TCR/CD3/MHC I/CD8 0.006 0.044 0.11 1 -0.17 15 16
RAB7A 0.09 0.2 0.44 28 -0.54 20 48
lysosomal transport 0.09 0.2 0.44 29 -0.51 20 49
FOS -0.11 0.48 0.49 12 -1.1 94 106
STAT4 (dimer) 0.084 0.2 0.45 31 -0.47 18 49
STAT5A (dimer) 0.077 0.19 0.43 10 -0.47 15 25
GZMA 0.067 0.2 0.55 12 -0.52 7 19
GZMB 0.066 0.2 0.56 12 -0.52 9 21
HLX 0 0 -10000 0 -10000 0 0
LCK 0.061 0.2 0.46 24 -0.49 15 39
TCR/CD3/MHC II/CD4 -0.023 0.12 0.16 22 -0.25 80 102
IL2/IL2R 0.063 0.044 -10000 0 -10000 0 0
MAPK14 0.092 0.23 0.5 19 -0.63 20 39
CCR5 0.075 0.17 0.39 36 -0.39 16 52
IL1B 0.029 0.037 0.11 8 -0.053 11 19
STAT6 0.052 0.098 0.31 13 -0.4 3 16
STAT4 0.035 0.009 -10000 0 0 29 29
STAT3 0.034 0.01 -10000 0 0 37 37
STAT1 0.034 0.01 -10000 0 0 40 40
NFKB1 0.035 0.007 -10000 0 0 18 18
NFKB2 0.025 0.017 -10000 0 0 158 158
IL12B 0.04 0.04 0.12 19 -0.055 11 30
CD8A 0 0 -10000 0 -10000 0 0
CD8B 0 0 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity -0.04 0.087 0.18 17 -0.22 29 46
IL2RB 0.033 0.011 -10000 0 0 53 53
proteasomal ubiquitin-dependent protein catabolic process 0.085 0.2 0.44 34 -0.44 18 52
IL2RG 0.035 0.008 -10000 0 0 24 24
IL12 0.061 0.06 0.18 20 -10000 0 20
STAT5A 0.036 0.004 -10000 0 0 5 5
CD247 -0.001 0.009 -10000 0 -0.023 42 42
IL2 0.036 0.005 -10000 0 0 10 10
SPHK2 0.034 0.009 -10000 0 0 34 34
FRAP1 0.035 0.007 -10000 0 0 17 17
IL12A 0.038 0.04 0.12 15 -0.051 30 45
IL12/IL12R/TYK2/JAK2 0.062 0.21 0.49 27 -0.51 15 42
MAP2K3 0.086 0.23 0.49 19 -0.63 21 40
RIPK2 0.036 0.006 -10000 0 0 14 14
MAP2K6 0.089 0.22 0.53 12 -0.6 18 30
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA 0.021 0.027 -10000 0 -0.012 182 182
IL18RAP 0.038 0.02 0.088 2 -0.041 22 24
IL12Rbeta1/TYK2 0.049 0.062 0.18 7 -0.15 14 21
EOMES -0.018 0.038 0.075 2 -0.099 48 50
STAT1 (dimer) 0.086 0.19 0.42 28 -0.43 11 39
T cell proliferation 0.074 0.18 0.4 34 -0.4 19 53
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 0.039 0.02 0.088 2 -0.041 22 24
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA 0.043 0.17 -10000 0 -0.46 24 24
ATF2 0.084 0.21 0.47 19 -0.59 20 39
Paxillin-independent events mediated by a4b1 and a4b7

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.002 0.038 -10000 0 -10000 0 0
CRKL 0.035 0.009 -10000 0 0 29 29
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
DOCK1 0.024 0.017 -10000 0 0 175 175
ITGA4 0.036 0.006 -10000 0 0 13 13
alpha4/beta7 Integrin/MAdCAM1 0.083 0.035 -10000 0 -0.12 5 5
EPO 0.025 0.017 -10000 0 0 166 166
alpha4/beta7 Integrin 0.052 0.011 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.035 0.008 -10000 0 0 23 23
alpha4/beta1 Integrin 0.039 0.025 -10000 0 -10000 0 0
EPO/EPOR (dimer) 0.035 0.026 -10000 0 -10000 0 0
lamellipodium assembly -0.015 0.1 -10000 0 -0.35 23 23
PIK3CA 0.031 0.013 -10000 0 0 80 80
PI3K 0.019 0.075 -10000 0 -0.16 73 73
ARF6 0.035 0.008 -10000 0 0 27 27
JAK2 0.01 0.03 -10000 0 -10000 0 0
PXN 0.036 0.004 -10000 0 0 7 7
PIK3R1 0.032 0.012 -10000 0 0 63 63
MADCAM1 0.034 0.009 -10000 0 0 32 32
cell adhesion 0.08 0.034 -10000 0 -0.12 5 5
CRKL/CBL 0.051 0.014 -10000 0 -10000 0 0
ITGB1 0.027 0.016 -10000 0 0 138 138
SRC -0.034 0.058 0.19 4 -10000 0 4
ITGB7 0.036 0.005 -10000 0 0 11 11
RAC1 0.024 0.017 -10000 0 0 173 173
alpha4/beta1 Integrin/VCAM1 0.003 0.077 -10000 0 -0.12 126 126
p130Cas/Crk/Dock1 -0.031 0.063 0.2 4 -0.19 8 12
VCAM1 0.022 0.018 -10000 0 0 196 196
RHOA 0.035 0.007 -10000 0 0 18 18
alpha4/beta1 Integrin/Paxillin/GIT1 0.067 0.043 -10000 0 -10000 0 0
BCAR1 -0.033 0.051 0.18 4 -10000 0 4
EPOR 0.035 0.008 -10000 0 0 28 28
mol:GDP 0 0 -10000 0 -10000 0 0
CBL 0.036 0.004 -10000 0 0 7 7
GIT1 0.036 0.003 -10000 0 0 4 4
Rac1/GTP -0.016 0.1 -10000 0 -0.37 22 22
IL1-mediated signaling events

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.025 0.019 -10000 0 -0.13 7 7
PRKCZ 0 0 -10000 0 -10000 0 0
MAP3K7IP2 0.033 0.011 -10000 0 0 46 46
ERC1 0 0 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.01 0.12 -10000 0 -0.27 67 67
IRAK/TOLLIP 0.028 0.033 -10000 0 -0.12 22 22
IKBKB 0.036 0.003 -10000 0 0 4 4
IKBKG 0.037 0 -10000 0 -10000 0 0
IL1 alpha/IL1R2 0.043 0.022 -10000 0 -10000 0 0
IL1A 0.035 0.007 -10000 0 0 22 22
IL1B 0.003 0.044 0.092 94 -10000 0 94
IRAK/TRAF6/p62/Atypical PKCs 0.053 0.05 -10000 0 -0.13 28 28
IL1R2 0.03 0.014 -10000 0 0 90 90
IL1R1 0.036 0.006 -10000 0 0 13 13
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.015 0.1 -10000 0 -0.29 40 40
TOLLIP 0.034 0.009 -10000 0 0 30 30
TICAM2 0 0 -10000 0 -10000 0 0
MAP3K3 0.036 0.004 -10000 0 0 7 7
TAK1/TAB1/TAB2 0.056 0.047 -10000 0 -0.14 19 19
IKK complex/ELKS -0.045 0.096 -10000 0 -0.25 17 17
JUN -0.039 0.041 0.15 3 -0.21 9 12
MAP3K7 0.034 0.01 -10000 0 0 41 41
IL1 beta fragment/IL1R1/IL1RAP/PI3K 0.032 0.11 -10000 0 -0.14 107 107
IL1 alpha/IL1R1/IL1RAP/MYD88 0.065 0.069 -10000 0 -0.13 50 50
PIK3R1 0.032 0.012 -10000 0 0 63 63
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.074 0.075 -10000 0 -0.12 49 49
IL1 beta fragment/IL1R1/IL1RAP 0.026 0.081 0.16 8 -0.14 83 91
NFKB1 0.035 0.007 -10000 0 0 18 18
MAPK8 -0.033 0.036 0.16 3 -0.2 7 10
IRAK1 -0.018 0.01 -10000 0 -0.11 5 5
IL1RN/IL1R1 0.053 0.01 -10000 0 -10000 0 0
IRAK4 0.035 0.007 -10000 0 0 18 18
PRKCI 0.035 0.008 -10000 0 0 26 26
TRAF6 0.036 0.005 -10000 0 0 10 10
PI3K 0.019 0.075 -10000 0 -0.16 73 73
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.008 0.12 0.16 2 -0.26 71 73
CHUK 0.025 0.017 -10000 0 0 163 163
IL1 beta fragment/IL1R1/IL1RAP/MYD88s 0.026 0.081 0.16 8 -0.14 83 91
IL1 beta/IL1R2 0.017 0.071 -10000 0 -0.14 71 71
IRAK/TRAF6/TAK1/TAB1/TAB2 0.059 0.067 -10000 0 -0.14 34 34
NF kappa B1 p50/RelA 0.016 0.098 -10000 0 -0.2 38 38
IRAK3 0.035 0.008 -10000 0 0 27 27
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 0.038 0.082 -10000 0 -0.13 81 81
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.008 0.076 -10000 0 -0.19 51 51
IL1 alpha/IL1R1/IL1RAP 0.049 0.053 -10000 0 -0.12 33 33
RELA 0.036 0.005 -10000 0 0 9 9
MAP3K7IP1 0.034 0.009 -10000 0 0 35 35
SQSTM1 0.034 0.009 -10000 0 0 35 35
MYD88 0.034 0.009 -10000 0 0 36 36
IRAK/TRAF6/MEKK3 0.049 0.038 -10000 0 -0.12 22 22
IL1RAP 0.03 0.014 -10000 0 0 94 94
UBE2N 0.036 0.006 -10000 0 0 13 13
IRAK/TRAF6 -0.039 0.062 0.062 69 -0.19 24 93
CASP1 0.029 0.015 -10000 0 0 108 108
IL1RN/IL1R2 0.045 0.021 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88 0.038 0.096 -10000 0 -0.15 91 91
TMEM189-UBE2V1 0 0 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.002 0.1 -10000 0 -0.3 38 38
PIK3CA 0.031 0.013 -10000 0 0 80 80
IL1RN 0.036 0.004 -10000 0 0 6 6
TRAF6/TAK1/TAB1/TAB2 0.065 0.059 -10000 0 -0.14 22 22
MAP2K6 -0.038 0.035 0.18 3 -0.2 7 10
IL6-mediated signaling events

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.064 0.26 0.54 18 -0.66 26 44
CRP 0.06 0.26 0.61 9 -0.76 17 26
cell cycle arrest 0.052 0.29 0.51 21 -0.75 30 51
TIMP1 0.005 0.36 0.56 14 -0.8 68 82
IL6ST 0.028 0.033 0.09 1 -0.049 34 35
Rac1/GDP 0.039 0.11 0.3 16 -0.3 11 27
AP1 0.012 0.2 -10000 0 -0.56 37 37
GAB2 0.034 0.012 0.065 1 -0.001 48 49
TNFSF11 0.058 0.26 0.53 12 -0.73 20 32
HSP90B1 0.001 0.22 0.3 3 -0.84 30 33
GAB1 0.033 0.013 -10000 0 -0.001 60 60
MAPK14 0.029 0.065 -10000 0 -0.3 3 3
AKT1 -0.013 0.17 -10000 0 -0.52 35 35
FOXO1 -0.014 0.16 -10000 0 -0.5 36 36
MAP2K6 0.028 0.07 0.19 1 -0.28 6 7
mol:GTP 0 0.004 -10000 0 -0.022 1 1
MAP2K4 0.033 0.14 0.34 24 -0.36 16 40
MITF 0.032 0.083 0.22 11 -0.29 9 20
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 0.033 0.011 -10000 0 0 46 46
A2M -0.076 0.34 -10000 0 -1.2 44 44
CEBPB 0.032 0.013 -10000 0 0 71 71
GRB2/SOS1/GAB family/SHP2 0.021 0.13 0.32 1 -0.48 23 24
STAT3 0.042 0.3 0.53 18 -0.8 30 48
STAT1 0.021 0.065 -10000 0 -0.72 3 3
CEBPD 0.024 0.33 0.54 11 -0.9 42 53
PIK3CA 0.031 0.014 -10000 0 -0.041 1 1
PI3K 0.019 0.075 -10000 0 -0.16 73 73
JUN 0.034 0.01 -10000 0 0 40 40
PIAS3/MITF 0.077 0.11 0.26 25 -0.29 10 35
MAPK11 0.026 0.064 -10000 0 -0.3 3 3
STAT3 (dimer)/FOXO1 -0.021 0.26 0.42 13 -0.62 53 66
GRB2/SOS1/GAB family 0.043 0.12 0.23 2 -0.31 30 32
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK 0.004 0.1 0.18 10 -0.29 36 46
GRB2 0.036 0.008 -10000 0 -0.002 18 18
JAK2 0.031 0.014 -10000 0 0 83 83
LBP 0.064 0.25 0.51 20 -0.61 29 49
PIK3R1 0.032 0.013 -10000 0 -0.001 64 64
JAK1 0.03 0.026 -10000 0 -0.042 45 45
MYC 0.014 0.36 0.57 14 -0.87 57 71
FGG 0.058 0.26 0.57 8 -0.77 17 25
macrophage differentiation 0.052 0.29 0.51 21 -0.75 30 51
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 0.054 0.074 -10000 0 -0.19 5 5
JUNB 0.053 0.29 0.51 25 -0.82 28 53
FOS 0.025 0.017 -10000 0 0 158 158
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 0.028 0.083 0.22 13 -0.29 10 23
STAT1/PIAS1 0.071 0.12 0.3 12 -0.35 7 19
GRB2/SOS1/GAB family/SHP2/PI3K -0.001 0.17 -10000 0 -0.5 36 36
STAT3 (dimer) 0.044 0.29 0.52 19 -0.79 30 49
PRKCD 0.11 0.22 0.41 95 -0.44 20 115
IL6R 0.03 0.027 -10000 0 -0.041 57 57
SOCS3 0.059 0.086 0.59 1 -10000 0 1
gp130 (dimer)/JAK1/JAK1/LMO4 0.045 0.087 0.18 1 -0.17 43 44
Rac1/GTP 0.033 0.11 0.31 10 -0.33 11 21
HCK 0.027 0.016 -10000 0 0 128 128
MAPKKK cascade 0.011 0.19 0.34 2 -0.59 35 37
bone resorption 0.06 0.25 0.52 13 -0.68 20 33
IRF1 0.053 0.29 0.54 18 -0.86 24 42
mol:GDP 0.031 0.09 0.23 18 -0.28 10 28
SOS1 0.001 0.004 0.025 10 -0.022 1 11
VAV1 0.03 0.09 0.23 21 -0.28 10 31
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 0.02 0.075 -10000 0 -0.32 13 13
PTPN11 0.015 0.099 -10000 0 -0.73 8 8
IL6/IL6RA 0.023 0.038 -10000 0 -10000 0 0
gp130 (dimer)/TYK2/TYK2/LMO4 0.047 0.074 -10000 0 -0.15 40 40
gp130 (dimer)/JAK2/JAK2/LMO4 0.048 0.063 -10000 0 -0.13 31 31
IL6 0.015 0.027 -10000 0 -0.045 11 11
PIAS3 0.036 0.006 -10000 0 0 14 14
PTPRE 0.01 0.03 -10000 0 -0.056 35 35
PIAS1 0.035 0.008 -10000 0 0 27 27
RAC1 0.024 0.018 -10000 0 0 174 174
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 0.018 0.052 0.17 5 -0.22 6 11
LMO4 0.029 0.033 0.09 1 -0.049 36 37
STAT3 (dimer)/PIAS3 0.015 0.26 0.46 6 -0.73 31 37
MCL1 -0.014 0.16 -10000 0 -0.7 17 17
S1P3 pathway

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.035 0.008 -10000 0 0 27 27
mol:S1P 0.001 0.001 0.017 4 -10000 0 4
S1P1/S1P/Gi -0.018 0.11 -10000 0 -0.26 63 63
GNAO1 0.031 0.014 -10000 0 -10000 0 0
S1P/S1P3/G12/G13 0.024 0.038 -10000 0 -0.1 28 28
AKT1 -0.012 0.16 -10000 0 -0.5 44 44
AKT3 0.01 0.077 -10000 0 -0.37 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.035 0.008 -10000 0 0 27 27
GNAI2 0.034 0.011 -10000 0 -10000 0 0
GNAI3 0.036 0.007 -10000 0 0 15 15
GNAI1 0.018 0.019 -10000 0 0 263 263
mol:GDP 0 0 -10000 0 -10000 0 0
S1PR3 0.001 0.002 0.018 4 -10000 0 4
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 0.033 0.01 -10000 0 0 45 45
mol:Ca2+ -0.001 0.1 0.19 1 -0.26 47 48
MAPK3 -0.008 0.098 0.17 1 -0.25 48 49
MAPK1 -0.003 0.094 0.17 1 -0.28 32 33
JAK2 -0.011 0.11 0.19 5 -0.31 43 48
CXCR4 -0.006 0.099 0.13 8 -0.26 47 55
FLT1 0.036 0.01 -10000 0 -10000 0 0
RhoA/GDP 0.024 0.019 -10000 0 -0.13 7 7
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
SRC -0.007 0.098 0.17 1 -0.25 48 49
S1P/S1P3/Gi 0 0.1 0.19 1 -0.26 46 47
RAC1 0.024 0.017 -10000 0 0 173 173
RhoA/GTP 0.012 0.11 0.18 1 -0.27 40 41
VEGFA 0.002 0.002 0.032 3 -10000 0 3
S1P/S1P2/Gi -0.004 0.099 0.16 1 -0.2 78 79
VEGFR1 homodimer/VEGFA homodimer 0.029 0.01 0.11 3 -10000 0 3
RHOA 0.035 0.007 -10000 0 0 18 18
S1P/S1P3/Gq 0.015 0.04 -10000 0 -0.15 26 26
GNAQ 0.034 0.009 -10000 0 0 31 31
GNAZ 0.031 0.014 -10000 0 -10000 0 0
G12/G13 0.025 0.047 -10000 0 -0.14 28 28
GNA14 0.034 0.009 -10000 0 0 30 30
GNA15 0.033 0.012 -10000 0 0 57 57
GNA12 0.023 0.018 -10000 0 0 193 193
GNA13 0.035 0.007 -10000 0 0 19 19
GNA11 0.033 0.011 -10000 0 0 54 54
Rac1/GTP 0.001 0.092 -10000 0 -0.29 27 27
Signaling events mediated by PTP1B

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.035 0.008 -10000 0 0 27 27
Jak2/Leptin Receptor -0.003 0.14 -10000 0 -0.33 53 53
PTP1B/AKT1 0 0.11 -10000 0 -0.27 41 41
FYN 0.03 0.014 -10000 0 0 90 90
p210 bcr-abl/PTP1B -0.01 0.11 0.18 1 -0.28 42 43
EGFR 0.009 0.016 -10000 0 -0.031 3 3
EGF/EGFR -0.033 0.09 -10000 0 -0.29 36 36
CSF1 0.036 0.005 -10000 0 0 8 8
AKT1 0.033 0.011 -10000 0 0 53 53
INSR 0.035 0.009 -10000 0 -0.001 26 26
PTP1B/N-cadherin -0.005 0.12 -10000 0 -0.28 51 51
Insulin Receptor/Insulin 0.02 0.11 -10000 0 -0.28 27 27
HCK 0.027 0.016 -10000 0 0 128 128
CRK 0.035 0.008 -10000 0 0 23 23
TYK2 -0.009 0.12 0.3 19 -0.29 40 59
EGF 0.027 0.024 -10000 0 -0.031 66 66
YES1 0.034 0.01 -10000 0 0 41 41
CAV1 0.007 0.14 0.22 27 -0.31 45 72
TXN 0.035 0.011 -10000 0 0 40 40
PTP1B/IRS1/GRB2 0.006 0.12 -10000 0 -0.3 36 36
cell migration 0.01 0.11 0.28 42 -0.18 1 43
STAT3 0.034 0.01 -10000 0 0 37 37
PRLR 0.038 0.004 -10000 0 -10000 0 0
ITGA2B 0.036 0.004 -10000 0 0 5 5
CSF1R 0.027 0.016 -10000 0 0 131 131
Prolactin Receptor/Prolactin 0.057 0.012 -10000 0 -10000 0 0
FGR 0.033 0.011 -10000 0 0 54 54
PTP1B/p130 Cas -0.012 0.1 0.16 1 -0.26 44 45
Crk/p130 Cas -0.001 0.11 -10000 0 -0.26 48 48
DOK1 -0.008 0.1 0.18 7 -0.29 34 41
JAK2 -0.014 0.13 -10000 0 -0.34 54 54
Jak2/Leptin Receptor/Leptin -0.014 0.12 -10000 0 -0.32 31 31
PIK3R1 0.032 0.012 -10000 0 0 63 63
PTPN1 -0.01 0.11 0.18 1 -0.28 42 43
LYN 0.031 0.013 -10000 0 0 74 74
CDH2 0.033 0.011 -10000 0 0 55 55
SRC 0.014 0.099 -10000 0 -0.46 17 17
ITGB3 0.036 0.003 -10000 0 0 4 4
CAT1/PTP1B -0.01 0.17 0.24 17 -0.36 64 81
CAPN1 0.036 0.006 -10000 0 -0.004 8 8
CSK 0.035 0.007 -10000 0 0 21 21
PI3K 0.011 0.13 -10000 0 -0.29 41 41
mol:H2O2 0.004 0.005 0.029 6 -10000 0 6
STAT3 (dimer) -0.012 0.11 -10000 0 -0.29 29 29
negative regulation of transcription -0.014 0.13 -10000 0 -0.34 54 54
FCGR2A 0.028 0.015 -10000 0 0 114 114
FER 0.036 0.008 -10000 0 -0.002 15 15
alphaIIb/beta3 Integrin 0.053 0.006 -10000 0 -10000 0 0
BLK 0.035 0.007 -10000 0 0 17 17
Insulin Receptor/Insulin/Shc 0.059 0.036 -10000 0 -0.13 8 8
RHOA 0.035 0.007 -10000 0 0 18 18
LEPR 0.035 0.007 -10000 0 0 20 20
BCAR1 0 0 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.035 0.007 -10000 0 0 17 17
mol:NADPH 0.001 0.003 -10000 0 -10000 0 0
TRPV6 -0.006 0.15 0.2 6 -0.35 59 65
PRL 0.038 0.007 -10000 0 -10000 0 0
SOCS3 0.022 0.051 -10000 0 -1.1 1 1
SPRY2 0.029 0.018 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1 0.056 0.046 -10000 0 -0.12 23 23
CSF1/CSF1R -0.002 0.13 -10000 0 -0.28 46 46
Ras protein signal transduction -0.01 0.069 0.57 5 -0.21 1 6
IRS1 0.033 0.011 -10000 0 0 52 52
INS 0.036 0.007 -10000 0 -0.002 15 15
LEP 0.024 0.017 -10000 0 0 173 173
STAT5B -0.004 0.11 0.17 2 -0.28 32 34
STAT5A -0.004 0.11 -10000 0 -0.29 29 29
GRB2 0.035 0.007 -10000 0 0 17 17
PDGFB-D/PDGFRB 0.001 0.12 0.18 1 -0.27 44 45
CSN2 0.013 0.041 -10000 0 -10000 0 0
PIK3CA 0.031 0.013 -10000 0 0 80 80
LAT -0.028 0.18 -10000 0 -0.46 65 65
YBX1 0.038 0.042 -10000 0 -0.29 8 8
LCK 0.035 0.007 -10000 0 0 17 17
SHC1 0.033 0.011 -10000 0 0 52 52
NOX4 0.034 0.015 -10000 0 0 82 82
Glypican 1 network

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer 0.052 0.056 -10000 0 -0.13 36 36
fibroblast growth factor receptor signaling pathway 0.051 0.055 -10000 0 -0.13 36 36
LAMA1 0 0 -10000 0 -10000 0 0
PRNP 0.033 0.011 -10000 0 0 52 52
GPC1/SLIT2 0.032 0.044 -10000 0 -0.14 23 23
SMAD2 -0.023 0.048 0.18 11 -0.2 3 14
GPC1/PrPc/Cu2+ 0.026 0.058 -10000 0 -0.14 52 52
GPC1/Laminin alpha1 0.015 0.04 -10000 0 -0.13 35 35
TDGF1 0.035 0.007 -10000 0 0 18 18
CRIPTO/GPC1 0.038 0.047 -10000 0 -0.14 29 29
APP/GPC1 0.034 0.058 -10000 0 -0.16 38 38
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.023 0.033 0.089 22 -0.12 22 44
FLT1 0.034 0.009 -10000 0 0 33 33
GPC1/TGFB/TGFBR1/TGFBR2 0.051 0.053 -10000 0 -0.12 34 34
SERPINC1 0.036 0.005 -10000 0 0 11 11
FYN -0.018 0.029 0.089 23 -0.12 8 31
FGR -0.022 0.033 0.089 23 -0.12 21 44
positive regulation of MAPKKK cascade -0.038 0.12 0.2 10 -0.3 61 71
SLIT2 0.029 0.015 -10000 0 0 103 103
GPC1/NRG 0.037 0.05 -10000 0 -0.14 35 35
NRG1 0.036 0.005 -10000 0 0 9 9
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.032 0.043 -10000 0 -0.12 35 35
LYN -0.022 0.033 0.089 22 -0.12 23 45
mol:Spermine -0.01 0.004 -10000 0 -10000 0 0
cell growth 0.051 0.055 -10000 0 -0.13 36 36
BMP signaling pathway -0.032 0.012 0 64 -10000 0 64
SRC -0.025 0.034 0.089 23 -0.12 28 51
TGFBR1 0.035 0.007 -10000 0 0 17 17
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A 0.018 0.018 -10000 0 0 262 262
GPC1 0.032 0.012 -10000 0 0 64 64
TGFBR1 (dimer) 0.035 0.007 -10000 0 0 17 17
VEGFA 0 0 -10000 0 -10000 0 0
BLK -0.025 0.034 0.089 24 -0.12 27 51
HCK -0.018 0.03 0.089 19 -0.12 16 35
FGF2 0.035 0.008 -10000 0 0 25 25
FGFR1 0.036 0.005 -10000 0 0 9 9
VEGFR1 homodimer 0.034 0.009 -10000 0 0 33 33
TGFBR2 0.035 0.009 -10000 0 0 29 29
cell death 0.034 0.057 -10000 0 -0.16 38 38
ATIII/GPC1 0.037 0.049 -10000 0 -0.14 33 33
PLA2G2A/GPC1 -0.005 0.074 -10000 0 -0.15 93 93
LCK -0.024 0.034 0.089 24 -0.12 25 49
neuron differentiation 0.037 0.05 -10000 0 -0.14 35 35
PrPc/Cu2+ 0.016 0.038 -10000 0 -0.13 31 31
APP 0.035 0.007 -10000 0 0 21 21
TGFBR2 (dimer) 0.034 0.009 -10000 0 0 29 29
p38 MAPK signaling pathway

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.012 0.05 -10000 0 -0.18 16 16
TRAF2/ASK1 0.032 0.043 -10000 0 -0.12 35 35
ATM 0.034 0.009 -10000 0 0 35 35
MAP2K3 0.014 0.099 0.24 1 -0.31 26 27
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.011 0.09 0.27 1 -0.3 19 20
hyperosmotic response 0 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
GADD45G 0.032 0.012 -10000 0 0 67 67
TXN 0.007 0.002 -10000 0 0 40 40
CALM1 0.033 0.011 -10000 0 0 54 54
GADD45A 0.031 0.013 -10000 0 0 75 75
GADD45B 0.03 0.014 -10000 0 0 89 89
MAP3K1 0.035 0.007 -10000 0 0 20 20
MAP3K6 0.035 0.007 -10000 0 0 20 20
MAP3K7 0.034 0.01 -10000 0 0 41 41
MAP3K4 0.032 0.012 -10000 0 0 66 66
mol:Ca2+ 0 0 -10000 0 -10000 0 0
ASK1/ASK2 0.032 0.053 -10000 0 -0.14 38 38
TAK1/TAB family 0.009 0.054 -10000 0 -0.31 11 11
RAC1/OSM/MEKK3 0.03 0.026 -10000 0 -0.1 5 5
TRAF2 0.036 0.006 -10000 0 0 15 15
RAC1/OSM/MEKK3/MKK3 0.012 0.075 -10000 0 -0.26 22 22
TRAF6 0.009 0.033 -10000 0 -0.2 12 12
RAC1 0.024 0.017 -10000 0 0 173 173
mol:LPS 0 0 -10000 0 -10000 0 0
CAMK2B 0.017 0.018 -10000 0 0 272 272
CCM2 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB 0.009 0.054 -10000 0 -0.13 53 53
MAPK11 0.033 0.011 -10000 0 0 49 49
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 0.011 0.066 -10000 0 -0.13 66 66
OSM/MEKK3 0.027 0.003 -10000 0 -10000 0 0
TAOK1 0.007 0.002 -10000 0 0 35 35
TAOK2 0.012 0.024 -10000 0 -0.2 6 6
TAOK3 0.006 0.041 -10000 0 -0.2 19 19
MAP3K7IP1 0.034 0.009 -10000 0 0 35 35
MAPK14 0.036 0.004 -10000 0 0 6 6
MAP3K7IP2 0.033 0.011 -10000 0 0 46 46
MAP3K5 0.03 0.014 -10000 0 0 90 90
MAP3K10 0.035 0.008 -10000 0 0 28 28
MAP3K3 0.036 0.004 -10000 0 0 7 7
TRX/ASK1 0.022 0.037 -10000 0 -0.16 16 16
GADD45/MTK1/MTK1 0.043 0.075 -10000 0 -0.13 64 64
ErbB2/ErbB3 signaling events

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.015 0.013 0.085 5 -10000 0 5
RAS family/GTP 0.013 0.11 0.22 1 -0.2 37 38
NFATC4 -0.021 0.067 0.19 13 -0.19 4 17
ERBB2IP 0.034 0.011 -10000 0 -0.001 42 42
HSP90 (dimer) 0 0 -10000 0 -10000 0 0
mammary gland morphogenesis -0.029 0.077 0.18 7 -0.21 7 14
JUN -0.004 0.087 0.2 8 -0.36 7 15
HRAS 0.034 0.009 -10000 0 0 32 32
DOCK7 -0.036 0.068 0.15 11 -0.18 19 30
ErbB2/ErbB3/neuregulin 1 beta/SHC 0.027 0.08 0.21 14 -0.13 84 98
AKT1 -0.01 0.008 0.015 20 -10000 0 20
BAD -0.015 0.014 0.085 7 -10000 0 7
MAPK10 0.007 0.072 0.16 36 -0.16 10 46
mol:GTP 0 0.001 0.003 2 -0.005 24 26
ErbB2/ErbB3/neuregulin 1 beta -0.03 0.083 0.2 7 -0.22 6 13
RAF1 -0.019 0.1 0.25 11 -0.24 32 43
ErbB2/ErbB3/neuregulin 2 0.002 0.073 0.2 17 -0.13 91 108
STAT3 -0.023 0.24 -10000 0 -0.9 35 35
cell migration -0.005 0.071 0.19 20 -0.18 15 35
mol:PI-3-4-5-P3 -0.001 0.002 0.004 18 -0.004 19 37
cell proliferation -0.041 0.24 0.42 4 -0.58 58 62
FOS -0.032 0.2 0.37 6 -0.42 90 96
NRAS 0.032 0.012 -10000 0 0 63 63
mol:Ca2+ -0.029 0.077 0.18 7 -0.21 7 14
MAPK3 -0.019 0.18 0.4 3 -0.48 38 41
MAPK1 -0.044 0.22 0.4 3 -0.57 50 53
JAK2 -0.027 0.078 0.17 17 -0.22 5 22
NF2 0.01 0.008 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.005 0.08 0.15 13 -0.16 88 101
NRG1 0.036 0.005 -10000 0 0 9 9
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
MAPK8 -0.014 0.087 0.2 3 -0.22 47 50
MAPK9 0.014 0.076 0.16 54 -0.15 3 57
ERBB2 -0.016 0.068 0.26 29 -10000 0 29
ERBB3 0.018 0.018 -10000 0 0 256 256
SHC1 0.033 0.011 -10000 0 0 52 52
RAC1 0.024 0.017 -10000 0 0 173 173
apoptosis 0.012 0.03 0.2 10 -0.07 4 14
STAT3 (dimer) -0.021 0.24 -10000 0 -0.88 35 35
RNF41 -0.02 0.019 0.076 10 -0.12 2 12
FRAP1 -0.015 0.012 0.084 5 -10000 0 5
RAC1-CDC42/GTP -0.022 0.044 -10000 0 -0.13 47 47
ErbB2/ErbB2/HSP90 (dimer) -0.025 0.008 -10000 0 -10000 0 0
CHRNA1 -0.007 0.15 0.35 5 -0.37 38 43
myelination -0.033 0.072 0.24 7 -0.22 2 9
PPP3CB -0.02 0.067 0.17 14 -0.21 4 18
KRAS 0.034 0.009 -10000 0 0 35 35
RAC1-CDC42/GDP 0.021 0.074 0.22 1 -0.16 45 46
NRG2 0.036 0.005 -10000 0 0 10 10
mol:GDP -0.005 0.08 0.15 13 -0.16 88 101
SOS1 0 0.001 -10000 0 -0.004 8 8
MAP2K2 -0.028 0.1 0.22 11 -0.25 35 46
SRC 0.036 0.006 -10000 0 0 14 14
mol:cAMP -0.001 0.001 0.003 7 -0.004 1 8
PTPN11 -0.031 0.083 0.18 19 -0.23 5 24
MAP2K1 -0.038 0.2 0.38 2 -0.55 38 40
heart morphogenesis -0.029 0.077 0.18 7 -0.21 7 14
RAS family/GDP 0.021 0.11 0.24 1 -0.18 67 68
GRB2 0.035 0.007 -10000 0 0 17 17
PRKACA 0.018 0.009 -10000 0 -10000 0 0
CHRNE 0.001 0.025 0.068 4 -0.12 7 11
HSP90AA1 0 0 -10000 0 -10000 0 0
activation of caspase activity 0.01 0.008 -10000 0 -0.015 20 20
nervous system development -0.029 0.077 0.18 7 -0.21 7 14
CDC42 0.035 0.008 -10000 0 0 24 24
PLK1 signaling events

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.001 0.009 0.026 1 -0.035 15 16
BUB1B -0.023 0.084 0.12 22 -0.22 64 86
PLK1 0.004 0.023 0.083 17 -0.071 3 20
PLK1S1 0.002 0.014 0.049 21 -0.044 1 22
KIF2A 0.004 0.021 0.073 17 -0.064 3 20
regulation of mitotic centrosome separation 0.005 0.023 0.083 17 -0.071 3 20
GOLGA2 0.035 0.008 -10000 0 0 28 28
Hec1/SPC24 -0.004 0.01 -10000 0 -0.055 5 5
WEE1 -0.032 0.13 -10000 0 -0.46 36 36
cytokinesis -0.021 0.11 0.15 12 -0.3 59 71
PP2A-alpha B56 0.051 0.087 -10000 0 -0.51 9 9
AURKA 0.002 0.016 0.056 21 -0.04 2 23
PICH/PLK1 -0.034 0.073 0.071 9 -0.18 87 96
CENPE 0.003 0.047 0.14 32 -0.1 6 38
RhoA/GTP 0.024 0.019 -10000 0 -0.13 7 7
positive regulation of microtubule depolymerization 0.004 0.02 0.073 17 -0.063 3 20
PPP2CA 0.035 0.007 -10000 0 0 21 21
FZR1 0.035 0.008 -10000 0 0 28 28
TPX2 -0.025 0.089 0.11 2 -0.22 83 85
PAK1 0.036 0.006 -10000 0 0 15 15
SPC24 0 0 -10000 0 -10000 0 0
FBXW11 0.035 0.008 -10000 0 0 25 25
CLSPN 0.01 0.025 0.1 1 -0.2 5 6
GORASP1 0.034 0.009 -10000 0 0 33 33
metaphase 0.001 0.003 0.015 11 -0.011 1 12
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.002 0.014 0.049 21 -0.044 1 22
G2 phase of mitotic cell cycle -0.001 0.002 0.01 7 -10000 0 7
STAG2 0.035 0.007 -10000 0 0 22 22
GRASP65/GM130/RAB1/GTP -0.02 0.14 -10000 0 -0.6 26 26
spindle elongation 0.005 0.023 0.083 17 -0.071 3 20
ODF2 0.035 0.009 -10000 0 0 29 29
BUB1 0.02 0.074 -10000 0 -0.57 7 7
TPT1 -0.002 0.05 -10000 0 -0.18 34 34
CDC25C 0.011 0.03 -10000 0 -0.22 7 7
CDC25B 0.012 0.032 -10000 0 -0.029 175 175
SGOL1 0.001 0.009 0.035 15 -0.026 1 16
RHOA 0.035 0.007 -10000 0 0 18 18
CCNB1/CDK1 -0.02 0.12 -10000 0 -0.24 92 92
CDC14B -0.011 0.004 0.01 6 -10000 0 6
CDC20 0.028 0.016 -10000 0 0 125 125
PLK1/PBIP1 -0.015 0.036 0.069 6 -0.089 77 83
mitosis -0.001 0.003 0.012 9 -10000 0 9
FBXO5 -0.017 0.061 0.12 17 -0.16 51 68
CDC2 0.015 0.023 -10000 0 -0.03 42 42
NDC80 0 0 -10000 0 -10000 0 0
metaphase plate congression 0.002 0.059 -10000 0 -0.26 23 23
ERCC6L -0.045 0.1 -10000 0 -0.22 92 92
NLP/gamma Tubulin 0.001 0.027 0.073 12 -0.1 21 33
microtubule cytoskeleton organization -0.002 0.05 -10000 0 -0.18 34 34
G2/M transition DNA damage checkpoint -0.001 0.002 0.01 5 -10000 0 5
PPP1R12A 0.035 0.008 -10000 0 0 24 24
interphase -0.001 0.002 0.01 5 -10000 0 5
PLK1/PRC1-2 0.007 0.075 0.13 1 -0.14 86 87
GRASP65/GM130/RAB1/GTP/PLK1 0.046 0.053 -10000 0 -0.12 29 29
RAB1A 0.035 0.007 -10000 0 0 18 18
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.002 0.018 0.066 18 -0.051 1 19
mitotic prometaphase -0.001 0.005 0.02 23 -10000 0 23
proteasomal ubiquitin-dependent protein catabolic process -0.048 0.1 0.18 2 -0.21 119 121
microtubule-based process 0.019 0.024 0.1 4 -0.066 2 6
Golgi organization 0.005 0.023 0.083 17 -0.071 3 20
Cohesin/SA2 0.02 0.033 0.1 4 -0.094 21 25
PPP1CB/MYPT1 0.046 0.036 -10000 0 -0.15 14 14
KIF20A 0.029 0.015 -10000 0 0 109 109
APC/C/CDC20 0.019 0.024 0.11 5 -10000 0 5
PPP2R1A 0.032 0.012 -10000 0 0 61 61
chromosome segregation -0.015 0.035 0.068 6 -0.088 77 83
PRC1 0.028 0.016 -10000 0 0 123 123
ECT2 0.001 0.059 0.14 51 -0.1 30 81
C13orf34 0.003 0.019 0.069 18 -0.056 2 20
NUDC 0.001 0.059 -10000 0 -0.26 23 23
regulation of attachment of spindle microtubules to kinetochore -0.023 0.083 0.12 22 -0.21 64 86
spindle assembly 0.002 0.025 0.085 15 -0.078 13 28
spindle stabilization 0.002 0.014 0.048 21 -0.044 1 22
APC/C/HCDH1 0.024 0.026 0.089 1 -0.12 15 16
MKLP2/PLK1 0.019 0.024 0.1 4 -0.066 2 6
CCNB1 0.014 0.028 -10000 0 -0.028 116 116
PPP1CB 0.036 0.006 -10000 0 0 15 15
BTRC 0.025 0.017 -10000 0 0 155 155
ROCK2 0.016 0.029 -10000 0 -0.21 3 3
TUBG1 0.002 0.05 0.1 1 -0.22 22 23
G2/M transition of mitotic cell cycle -0.047 0.1 0.14 18 -0.23 92 110
MLF1IP -0.009 0.006 0.01 1 -10000 0 1
INCENP 0.036 0.005 -10000 0 0 8 8
mTOR signaling pathway

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0.036 0.006 -10000 0 0 15 15
MKNK1 0.034 0.009 -10000 0 0 34 34
mol:PIP3 -0.018 0.057 0.1 5 -0.23 22 27
FRAP1 0.03 0.1 0.28 2 -0.46 14 16
AKT1 0.007 0.1 0.17 94 -0.26 29 123
INSR 0.035 0.008 -10000 0 0 25 25
Insulin Receptor/Insulin 0.046 0.013 -10000 0 -10000 0 0
mol:GTP 0.032 0.11 0.2 58 -0.26 29 87
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit -0.005 0.047 -10000 0 -0.19 15 15
TSC2 0.035 0.008 -10000 0 0 28 28
RHEB/GDP 0.002 0.076 -10000 0 -0.24 28 28
TSC1 0.034 0.01 -10000 0 0 40 40
Insulin Receptor/IRS1 0.022 0.061 -10000 0 -0.25 23 23
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0.023 0.071 0.16 1 -0.24 11 12
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0 0 -10000 0 -10000 0 0
RPS6KB1 0.036 0.085 0.26 10 -0.32 4 14
MAP3K5 -0.026 0.084 0.16 1 -0.22 73 74
PIK3R1 0.033 0.012 -10000 0 0 63 63
apoptosis -0.026 0.084 0.16 1 -0.22 73 74
mol:LY294002 0 0 0.001 9 -0.001 18 27
EIF4B 0.029 0.082 0.24 11 -0.31 5 16
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.03 0.072 0.23 8 -0.28 4 12
eIF4E/eIF4G1/eIF4A1 0.009 0.075 -10000 0 -0.3 16 16
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.022 0.082 -10000 0 -0.23 32 32
mTOR/RHEB/GTP/Raptor/GBL 0.006 0.06 0.19 9 -0.2 13 22
FKBP1A 0.034 0.01 -10000 0 0 44 44
RHEB/GTP 0.014 0.086 0.23 5 -0.24 27 32
mol:Amino Acids 0 0 0.001 9 -0.001 18 27
FKBP12/Rapamycin 0.022 0.023 -10000 0 -0.13 10 10
PDPK1 -0.021 0.061 0.16 15 -0.23 19 34
EIF4E 0.034 0.01 -10000 0 0 38 38
ASK1/PP5C -0.034 0.24 -10000 0 -0.56 79 79
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.02 0.11 -10000 0 -0.34 30 30
TSC1/TSC2 0.035 0.12 0.21 58 -0.28 29 87
tumor necrosis factor receptor activity 0 0 0.001 18 -0.001 9 27
RPS6 0.031 0.013 -10000 0 0 81 81
PPP5C 0.034 0.01 -10000 0 0 39 39
EIF4G1 0.033 0.011 -10000 0 0 49 49
IRS1 0.001 0.058 -10000 0 -0.26 23 23
INS 0.036 0.006 -10000 0 0 14 14
PTEN 0.026 0.017 -10000 0 0 148 148
PDK2 -0.021 0.061 0.16 15 -0.23 19 34
EIF4EBP1 -0.02 0.25 -10000 0 -1.1 24 24
PIK3CA 0.031 0.014 -10000 0 0 80 80
PPP2R5D 0.025 0.097 0.27 3 -0.41 14 17
peptide biosynthetic process -0.02 0.017 0.18 3 -10000 0 3
RHEB 0.024 0.017 -10000 0 0 173 173
EIF4A1 0.035 0.007 -10000 0 0 17 17
mol:Rapamycin 0 0.001 0.003 29 -0.003 16 45
EEF2 -0.021 0.017 0.18 3 -10000 0 3
eIF4E/4E-BP1 -0.004 0.24 -10000 0 -1.1 24 24
Stabilization and expansion of the E-cadherin adherens junction

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization 0.01 0.057 -10000 0 -0.2 28 28
epithelial cell differentiation 0.063 0.051 -10000 0 -0.14 25 25
CYFIP2 0.031 0.013 -10000 0 0 78 78
ENAH -0.041 0.07 0.25 11 -0.26 8 19
EGFR 0.009 0.016 -10000 0 0 381 381
EPHA2 0.033 0.011 -10000 0 0 54 54
MYO6 -0.029 0.049 0.18 9 -0.21 13 22
CTNNB1 0.036 0.006 -10000 0 0 15 15
ABI1/Sra1/Nap1 0.031 0.063 -10000 0 -0.12 58 58
AQP5 -0.02 0.051 0.21 2 -0.28 9 11
CTNND1 0.034 0.009 -10000 0 0 32 32
mol:PI-4-5-P2 -0.031 0.044 0.18 6 -0.2 13 19
regulation of calcium-dependent cell-cell adhesion -0.028 0.044 0.18 8 -0.19 8 16
EGF 0.035 0.008 -10000 0 0 25 25
NCKAP1 0.036 0.002 -10000 0 0 2 2
AQP3 -0.035 0.075 -10000 0 -0.3 32 32
cortical microtubule organization 0.063 0.051 -10000 0 -0.14 25 25
GO:0000145 -0.03 0.04 0.16 6 -0.19 13 19
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.07 0.054 -10000 0 -0.14 25 25
MLLT4 0.034 0.009 -10000 0 0 36 36
ARF6/GDP -0.052 0.039 -10000 0 -0.16 34 34
ARF6 0.035 0.008 -10000 0 0 27 27
Ephrin A1/EPHA2/NCK1/GIT1 0.076 0.052 -10000 0 -0.12 24 24
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.029 0.079 0.16 1 -0.28 36 37
PVRL2 0.034 0.009 -10000 0 0 35 35
ZYX -0.021 0.046 0.18 6 -0.21 15 21
ARF6/GTP 0.079 0.059 -10000 0 -0.12 23 23
CDH1 0.034 0.01 -10000 0 0 38 38
EGFR/EGFR/EGF/EGF -0.001 0.059 -10000 0 -0.13 66 66
RhoA/GDP 0.063 0.056 -10000 0 -0.14 29 29
actin cytoskeleton organization -0.024 0.045 0.17 6 -0.22 12 18
IGF-1R heterotetramer 0.032 0.012 -10000 0 0 57 57
GIT1 0.036 0.003 -10000 0 0 4 4
IGF1R 0.033 0.012 -10000 0 0 57 57
IGF1 0.035 0.008 -10000 0 0 23 23
DIAPH1 -0.12 0.27 -10000 0 -0.57 59 59
Wnt receptor signaling pathway -0.063 0.051 0.14 25 -10000 0 25
RHOA 0.035 0.007 -10000 0 0 18 18
RhoA/GTP -0.053 0.041 -10000 0 -0.16 38 38
CTNNA1 0.035 0.007 -10000 0 0 20 20
VCL -0.024 0.046 0.17 6 -0.23 12 18
EFNA1 0.033 0.011 -10000 0 0 50 50
LPP -0.03 0.045 0.18 4 -0.22 13 17
Ephrin A1/EPHA2 0.046 0.062 -10000 0 -0.14 40 40
SEC6/SEC8 -0.044 0.028 -10000 0 -0.14 25 25
MGAT3 -0.028 0.044 0.19 8 -0.19 8 16
HGF/MET 0.036 0.05 -10000 0 -0.14 16 16
HGF 0.024 0.017 -10000 0 0 177 177
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.057 -10000 0 -0.21 28 28
actin cable formation -0.039 0.1 0.32 9 -0.3 32 41
KIAA1543 -0.025 0.036 0.16 7 -0.18 8 15
KIFC3 -0.031 0.042 0.19 5 -0.19 8 13
NCK1 0.035 0.008 -10000 0 0 27 27
EXOC3 0.036 0.003 -10000 0 0 4 4
ACTN1 -0.026 0.049 0.19 7 -0.21 16 23
NCK1/GIT1 0.05 0.022 -10000 0 -0.14 5 5
mol:GDP 0.063 0.051 -10000 0 -0.14 25 25
EXOC4 0 0 -10000 0 -10000 0 0
STX4 -0.028 0.03 0.053 22 -0.13 25 47
PIP5K1C -0.031 0.045 0.18 6 -0.21 13 19
LIMA1 0 0 -10000 0 -10000 0 0
ABI1 0.026 0.017 -10000 0 0 152 152
ROCK1 -0.034 0.085 0.34 11 -0.29 5 16
adherens junction assembly -0.023 0.073 0.23 6 -0.33 14 20
IGF-1R heterotetramer/IGF1 0.048 0.062 -10000 0 -0.14 37 37
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.023 -10000 0 -0.14 3 3
MET 0.023 0.018 -10000 0 0 191 191
PLEKHA7 -0.028 0.03 0.053 22 -0.13 25 47
mol:GTP 0.073 0.051 -10000 0 -0.12 24 24
establishment of epithelial cell apical/basal polarity -0.038 0.039 0.12 13 -0.18 10 23
cortical actin cytoskeleton stabilization 0.01 0.057 -10000 0 -0.2 28 28
regulation of cell-cell adhesion -0.024 0.045 0.17 6 -0.22 12 18
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.057 -10000 0 -0.21 28 28
Hedgehog signaling events mediated by Gli proteins

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.035 0.007 -10000 0 0 21 21
HDAC2 0.032 0.012 -10000 0 0 67 67
GNB1/GNG2 0.028 0.034 -10000 0 -0.11 14 14
forebrain development 0.034 0.063 0.25 4 -0.42 3 7
GNAO1 0.03 0.014 -10000 0 0 87 87
SMO/beta Arrestin2 0.033 0.031 -10000 0 -0.14 4 4
SMO 0.024 0.018 -10000 0 0 176 176
ARRB2 0.035 0.008 -10000 0 0 26 26
GLI3/SPOP 0.002 0.11 0.27 1 -0.31 35 36
mol:GTP 0 0.001 -10000 0 -10000 0 0
GSK3B 0.034 0.01 -10000 0 0 40 40
GNAI2 0.034 0.01 -10000 0 0 43 43
SIN3/HDAC complex 0.055 0.041 -10000 0 -0.12 17 17
GNAI1 0.018 0.018 -10000 0 0 263 263
XPO1 0.037 0.005 -10000 0 0 5 5
GLI1/Su(fu) 0.012 0.047 -10000 0 -0.3 5 5
SAP30 0.035 0.007 -10000 0 0 20 20
mol:GDP 0.024 0.018 -10000 0 0 176 176
MIM/GLI2A 0.041 0.013 0.12 11 -10000 0 11
IFT88 0.035 0.008 -10000 0 0 28 28
GNAI3 0.036 0.006 -10000 0 0 15 15
GLI2 0.001 0.089 -10000 0 -0.34 21 21
GLI3 -0.013 0.1 0.27 1 -0.31 32 33
CSNK1D 0.035 0.007 -10000 0 0 20 20
CSNK1E 0.032 0.012 -10000 0 0 67 67
SAP18 0.034 0.01 -10000 0 0 41 41
embryonic digit morphogenesis 0.035 0.008 -10000 0 0 28 28
GNG2 0 0 -10000 0 -10000 0 0
Gi family/GTP -0.01 0.088 -10000 0 -0.2 69 69
SIN3B 0.034 0.009 -10000 0 0 29 29
SIN3A 0 0 -10000 0 -10000 0 0
GLI3/Su(fu) -0.012 0.072 -10000 0 -0.26 26 26
GLI2/Su(fu) -0.003 0.072 -10000 0 -0.31 17 17
FOXA2 0.05 0.041 -10000 0 -0.45 2 2
neural tube patterning 0.034 0.063 0.25 4 -0.42 3 7
SPOP 0.035 0.008 -10000 0 0 23 23
Su(fu)/PIAS1 0.047 0.038 0.098 151 -0.083 9 160
GNB1 0.035 0.007 -10000 0 0 20 20
CSNK1G2 0.034 0.009 -10000 0 0 30 30
CSNK1G3 0.036 0.006 -10000 0 0 13 13
MTSS1 0.041 0.013 0.12 11 -10000 0 11
embryonic limb morphogenesis 0.034 0.063 0.25 4 -0.42 3 7
SUFU 0.002 0.01 -10000 0 -0.11 4 4
LGALS3 0.028 0.015 -10000 0 0 114 114
catabolic process 0.012 0.14 0.31 2 -0.42 33 35
GLI3A/CBP 0.044 0.008 -10000 0 -10000 0 0
KIF3A 0.033 0.011 -10000 0 0 55 55
GLI1 0.034 0.064 0.25 4 -0.43 3 7
RAB23 0.034 0.009 -10000 0 0 31 31
CSNK1A1 0.036 0.006 -10000 0 0 14 14
IFT172 0 0 -10000 0 -10000 0 0
RBBP7 0.036 0.005 -10000 0 0 8 8
Su(fu)/Galectin3 0.038 0.04 0.098 123 -0.11 8 131
GNAZ 0.031 0.013 -10000 0 0 81 81
RBBP4 0.033 0.011 -10000 0 0 56 56
CSNK1G1 0.036 0.006 -10000 0 0 14 14
PIAS1 0.035 0.008 -10000 0 0 27 27
PRKACA 0.035 0.008 -10000 0 0 25 25
GLI2/SPOP 0.016 0.097 -10000 0 -0.32 25 25
STK36 0.001 0.003 0.022 4 -10000 0 4
Gi family/GNB1/GNG2/GDP -0.015 0.1 -10000 0 -0.36 30 30
PTCH1 0.033 0.059 0.23 4 -0.38 3 7
MIM/GLI1 0.057 0.069 0.35 2 -0.39 3 5
CREBBP 0.044 0.008 -10000 0 -10000 0 0
Su(fu)/SIN3/HDAC complex 0.002 0.091 0.16 2 -0.24 44 46
TCR signaling in naïve CD8+ T cells

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC 0.027 0.073 0.19 21 -0.27 9 30
FYN -0.011 0.1 0.23 10 -0.3 33 43
LAT/GRAP2/SLP76 0.02 0.072 0.22 4 -0.29 10 14
IKBKB 0.036 0.003 -10000 0 0 4 4
AKT1 0.005 0.083 0.2 18 -0.24 21 39
B2M 0.036 0.01 -10000 0 0 27 27
IKBKG -0.003 0.034 0.086 22 -0.095 11 33
MAP3K8 0.022 0.018 -10000 0 0 196 196
mol:Ca2+ -0.01 0.01 0.088 1 -0.038 2 3
integrin-mediated signaling pathway 0.024 0.007 -10000 0 -0.11 1 1
LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.007 0.1 0.24 18 -0.28 25 43
TRPV6 0.4 0.59 1.2 168 -10000 0 168
CD28 0.037 0.001 -10000 0 -10000 0 0
SHC1 0.018 0.077 0.2 30 -0.32 9 39
receptor internalization 0.018 0.06 0.17 8 -0.29 8 16
PRF1 -0.14 0.31 -10000 0 -0.6 149 149
KRAS 0.034 0.009 -10000 0 0 35 35
GRB2 0.035 0.007 -10000 0 0 17 17
COT/AKT1 0.006 0.063 0.19 6 -0.21 18 24
LAT 0.012 0.072 0.21 13 -0.31 10 23
EntrezGene:6955 0.001 0.004 0.014 41 -10000 0 41
CD3D 0.035 0.011 -10000 0 0 44 44
CD3E 0.038 0.007 -10000 0 0 9 9
CD3G 0.037 0.008 -10000 0 0 17 17
RASGRP2 0.006 0.02 -10000 0 -0.14 6 6
RASGRP1 -0.024 0.13 0.22 27 -0.24 93 120
HLA-A 0.037 0.007 -10000 0 0 13 13
RASSF5 0 0 -10000 0 -10000 0 0
RAP1A/GTP/RAPL 0.024 0.007 -10000 0 -0.11 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.009 0.053 0.13 37 -0.1 18 55
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.005 0.037 -10000 0 -0.12 25 25
PRKCA -0.001 0.057 0.17 22 -0.18 6 28
GRAP2 0.034 0.009 -10000 0 0 35 35
mol:IP3 0.002 0.053 -10000 0 -0.24 8 8
EntrezGene:6957 0.001 0.004 0.014 41 -10000 0 41
TCR/CD3/MHC I/CD8 0.018 0.048 0.15 11 -0.17 11 22
ORAI1 -0.35 0.5 0.38 5 -1.1 168 173
CSK 0.013 0.072 0.21 14 -0.3 11 25
B7 family/CD28 0.062 0.096 0.26 27 -0.29 9 36
CHUK 0.025 0.017 -10000 0 0 163 163
TCR/CD3/MHC I/CD8/LCK/ZAP-70 0.015 0.074 0.2 9 -0.32 11 20
PTPN6 0.008 0.076 0.22 12 -0.31 12 24
VAV1 0.018 0.076 0.21 26 -0.31 9 35
Monovalent TCR/CD3 0.022 0.017 0.1 9 -10000 0 9
CBL 0.036 0.004 -10000 0 0 7 7
LCK 0.006 0.09 0.23 14 -0.28 19 33
PAG1 0.015 0.071 0.2 13 -0.3 11 24
RAP1A 0.036 0.005 -10000 0 0 11 11
TCR/CD3/MHC I/CD8/LCK 0.014 0.075 0.2 10 -0.31 12 22
CD80 0.036 0.007 -10000 0 0 16 16
CD86 0.032 0.012 -10000 0 0 64 64
PDK1/CARD11/BCL10/MALT1 0.002 0.046 -10000 0 -0.14 24 24
HRAS 0.034 0.009 -10000 0 0 32 32
GO:0035030 0.011 0.073 0.19 24 -0.24 11 35
CD8A 0.001 0.004 0.015 41 -10000 0 41
CD8B 0.001 0.004 0.015 43 -10000 0 43
PTPRC 0.029 0.015 -10000 0 0 110 110
PDK1/PKC theta 0.006 0.09 0.23 24 -0.28 15 39
CSK/PAG1 0.011 0.071 0.21 13 -0.29 11 24
SOS1 0 0 -10000 0 -10000 0 0
peptide-MHC class I 0.049 0.035 -10000 0 -0.14 13 13
GRAP2/SLP76 0.029 0.083 0.23 6 -0.3 12 18
STIM1 -0.06 0.18 1.2 7 -10000 0 7
RAS family/GTP 0.004 0.072 0.16 22 -0.16 37 59
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin 0.019 0.062 0.18 8 -0.3 8 16
mol:DAG -0.02 0.036 -10000 0 -0.22 8 8
RAP1A/GDP 0.009 0.027 0.069 29 -0.051 15 44
PLCG1 0.035 0.007 -10000 0 0 19 19
CD247 0.001 0.004 0.014 41 -10000 0 41
cytotoxic T cell degranulation -0.14 0.3 -10000 0 -0.58 149 149
RAP1A/GTP 0.003 0.008 -10000 0 -0.053 6 6
mol:PI-3-4-5-P3 0.009 0.09 0.23 19 -0.24 25 44
LAT/GRAP2/SLP76/VAV1/PLCgamma1 0.011 0.067 0.2 2 -0.29 8 10
NRAS 0.032 0.012 -10000 0 0 63 63
ZAP70 0.037 0.002 -10000 0 0 2 2
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
LAT/GRAP2/SLP76/VAV1 0.01 0.066 0.2 6 -0.3 7 13
MALT1 0.034 0.009 -10000 0 0 32 32
TRAF6 0.036 0.005 -10000 0 0 10 10
CD8 heterodimer 0.003 0.008 0.027 44 -10000 0 44
CARD11 0 0 -10000 0 -10000 0 0
PRKCB -0.016 0.026 -10000 0 -0.16 8 8
PRKCE -0.001 0.057 0.17 21 -0.18 6 27
PRKCQ 0.008 0.094 0.24 22 -0.3 15 37
LCP2 0.031 0.013 -10000 0 0 77 77
BCL10 0.035 0.007 -10000 0 0 20 20
regulation of survival gene product expression 0.005 0.076 0.19 21 -0.22 19 40
IKK complex -0.002 0.038 0.12 18 -0.088 4 22
RAS family/GDP -0.004 0.015 -10000 0 -0.04 37 37
MAP3K14 0.009 0.063 0.17 26 -0.17 18 44
PDPK1 0.005 0.079 0.21 20 -0.23 19 39
TCR/CD3/MHC I/CD8/Fyn 0.01 0.068 0.18 1 -0.28 12 13
Neurotrophic factor-mediated Trk receptor signaling

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.035 0.009 -10000 0 0 29 29
RAS family/GTP/Tiam1 -0.006 0.085 -10000 0 -0.2 65 65
NT3 (dimer)/TRKC 0.046 0.026 -10000 0 -0.14 6 6
NT3 (dimer)/TRKB 0.026 0.069 -10000 0 -0.12 73 73
SHC/Grb2/SOS1/GAB1/PI3K -0.008 0.095 -10000 0 -0.21 75 75
RAPGEF1 0.035 0.007 -10000 0 0 19 19
BDNF 0.032 0.012 -10000 0 0 67 67
PIK3CA 0.031 0.013 -10000 0 0 80 80
DYNLT1 0.033 0.01 -10000 0 0 44 44
NTRK1 0.035 0.006 -10000 0 0 16 16
NTRK2 0.026 0.016 -10000 0 0 142 142
NTRK3 0.034 0.01 -10000 0 0 38 38
NT-4/5 (dimer)/TRKB 0.013 0.058 -10000 0 -0.12 77 77
neuron apoptosis -0.007 0.12 0.32 42 -0.23 1 43
SHC 2-3/Grb2 0.007 0.13 0.24 1 -0.34 42 43
SHC1 0.033 0.011 -10000 0 0 52 52
SHC2 -0.012 0.12 -10000 0 -0.43 29 29
SHC3 -0.012 0.12 -10000 0 -0.41 31 31
STAT3 (dimer) 0.022 0.087 -10000 0 -0.28 36 36
NT3 (dimer)/TRKA 0.059 0.03 -10000 0 -10000 0 0
RIN/GDP 0.001 0.074 0.18 5 -0.22 25 30
GIPC1 0.035 0.008 -10000 0 0 24 24
KRAS 0.034 0.009 -10000 0 0 35 35
DNAJA3 -0.005 0.04 0.14 3 -0.16 3 6
RIN/GTP 0.011 0.035 -10000 0 -0.13 26 26
CCND1 -0.011 0.11 -10000 0 -0.49 25 25
MAGED1 0.035 0.008 -10000 0 0 26 26
PTPN11 0.036 0.005 -10000 0 0 11 11
RICS 0.033 0.011 -10000 0 0 46 46
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.04 0.031 -10000 0 -0.12 14 14
GRB2 0.035 0.007 -10000 0 0 17 17
NGF (dimer)/TRKA/MATK 0.045 0.014 -10000 0 -10000 0 0
TRKA/NEDD4-2 0.048 0.019 -10000 0 -0.14 1 1
ELMO1 0.018 0.018 -10000 0 0 257 257
RhoG/GTP/ELMO1/DOCK1 0.008 0.046 -10000 0 -0.12 46 46
NGF 0 0 -10000 0 -10000 0 0
HRAS 0.034 0.009 -10000 0 0 32 32
DOCK1 0.024 0.017 -10000 0 0 175 175
GAB2 0.033 0.011 -10000 0 0 47 47
RIT2 0.024 0.017 -10000 0 0 170 170
RIT1 0.032 0.012 -10000 0 0 60 60
FRS2 0.034 0.009 -10000 0 0 30 30
DNM1 0.035 0.008 -10000 0 0 26 26
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.035 0.008 -10000 0 0 23 23
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP 0.009 0.048 0.16 2 -0.17 12 14
mol:GDP -0.001 0.1 0.22 5 -0.32 24 29
NGF (dimer) 0 0 -10000 0 -10000 0 0
RhoG/GDP 0.002 0.043 -10000 0 -0.13 45 45
RIT1/GDP 0.008 0.081 0.19 6 -0.23 23 29
TIAM1 0.033 0.011 -10000 0 0 46 46
PIK3R1 0.032 0.012 -10000 0 0 63 63
BDNF (dimer)/TRKB 0.027 0.069 -10000 0 -0.12 70 70
KIDINS220/CRKL/C3G 0.05 0.015 -10000 0 -10000 0 0
SHC/RasGAP 0.037 0.051 -10000 0 -0.15 31 31
FRS2 family/SHP2 0.067 0.028 -10000 0 -0.12 6 6
SHC/GRB2/SOS1/GAB1 0.048 0.046 -10000 0 -0.11 25 25
RIT1/GTP 0.015 0.04 -10000 0 -0.13 35 35
NT3 (dimer) 0.035 0.008 -10000 0 0 23 23
RAP1/GDP -0.002 0.06 -10000 0 -0.18 27 27
KIDINS220/CRKL 0.034 0.009 -10000 0 0 29 29
BDNF (dimer) 0.032 0.012 -10000 0 0 67 67
ubiquitin-dependent protein catabolic process 0.043 0.017 -10000 0 -0.11 1 1
Schwann cell development -0.01 0.016 -10000 0 -0.056 34 34
EHD4 0.034 0.01 -10000 0 0 41 41
FRS2 family/GRB2/SOS1 0.062 0.029 -10000 0 -0.11 8 8
FRS2 family/SHP2/CRK family/C3G/GAB2 0.008 0.07 -10000 0 -0.25 20 20
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.036 0.005 -10000 0 0 11 11
CDC42/GTP 0.019 0.081 -10000 0 -0.15 68 68
ABL1 0.032 0.013 -10000 0 0 70 70
SH2B family/GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
Rap1/GTP 0.003 0.068 -10000 0 -0.22 18 18
STAT3 0.022 0.087 -10000 0 -0.28 36 36
axon guidance 0.005 0.07 -10000 0 -0.14 73 73
MAPK3 -0.007 0.055 0.18 37 -10000 0 37
MAPK1 -0.008 0.05 0.18 30 -10000 0 30
CDC42/GDP 0.011 0.08 0.18 10 -0.22 23 33
NTF3 0.035 0.008 -10000 0 0 23 23
NTF4 0 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM 0.043 0.025 -10000 0 -0.12 9 9
PI3K 0.019 0.075 -10000 0 -0.16 73 73
FRS3 0.036 0.002 -10000 0 0 2 2
FAIM 0.034 0.009 -10000 0 0 30 30
GAB1 0.032 0.012 -10000 0 0 59 59
RASGRF1 -0.006 0.039 0.14 2 -0.13 4 6
SOS1 0 0 -10000 0 -10000 0 0
MCF2L -0.018 0.02 0.089 10 -0.12 2 12
RGS19 0.033 0.011 -10000 0 0 51 51
CDC42 0.035 0.008 -10000 0 0 24 24
RAS family/GTP 0.009 0.1 0.23 1 -0.38 22 23
Rac1/GDP 0.009 0.068 0.18 7 -0.23 18 25
NGF (dimer)/TRKA/GRIT 0.039 0.035 -10000 0 -0.12 21 21
neuron projection morphogenesis -0.035 0.24 -10000 0 -0.87 36 36
NGF (dimer)/TRKA/NEDD4-2 0.043 0.017 -10000 0 -0.12 1 1
MAP2K1 -0.011 0.058 0.18 17 -0.19 6 23
NGFR 0.031 0.013 -10000 0 0 71 71
NGF (dimer)/TRKA/GIPC/GAIP 0.014 0.043 -10000 0 -0.22 9 9
RAS family/GTP/PI3K -0.023 0.1 -10000 0 -0.21 99 99
FRS2 family/SHP2/GRB2/SOS1 0.076 0.039 -10000 0 -0.14 10 10
NRAS 0.032 0.012 -10000 0 0 63 63
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
PRKCI 0.035 0.008 -10000 0 0 26 26
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCZ 0 0 -10000 0 -10000 0 0
MAPKKK cascade 0.011 0.086 -10000 0 -0.48 12 12
RASA1 0.034 0.009 -10000 0 0 32 32
TRKA/c-Abl 0.032 0.058 -10000 0 -0.14 48 48
SQSTM1 0.034 0.009 -10000 0 0 35 35
BDNF (dimer)/TRKB/GIPC 0.049 0.074 -10000 0 -0.12 66 66
NGF (dimer)/TRKA/p62/Atypical PKCs 0.053 0.033 -10000 0 -0.1 14 14
MATK 0.034 0.009 -10000 0 0 30 30
NEDD4L 0.033 0.01 -10000 0 0 44 44
RAS family/GDP -0.02 0.056 -10000 0 -0.16 48 48
NGF (dimer)/TRKA 0.009 0.04 0.15 4 -0.13 4 8
Rac1/GTP -0.014 0.055 -10000 0 -0.2 24 24
FRS2 family/SHP2/CRK family 0.087 0.056 -10000 0 -0.12 17 17
Class I PI3K signaling events mediated by Akt

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.018 0.021 0.092 16 -10000 0 16
BAD/BCL-XL/YWHAZ 0.048 0.034 -10000 0 -0.12 12 12
CDKN1B -0.024 0.12 -10000 0 -0.33 57 57
CDKN1A -0.024 0.12 -10000 0 -0.33 57 57
FRAP1 0.035 0.007 -10000 0 0 17 17
PRKDC 0.033 0.01 -10000 0 0 44 44
FOXO3 -0.019 0.11 -10000 0 -0.31 58 58
AKT1 -0.019 0.12 -10000 0 -0.33 58 58
BAD 0.036 0.006 -10000 0 0 14 14
AKT3 0.014 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 -0.019 0.11 -10000 0 -0.31 58 58
AKT1/ASK1 -0.009 0.12 -10000 0 -0.32 57 57
BAD/YWHAZ 0.063 0.037 -10000 0 -0.13 12 12
RICTOR 0 0 -10000 0 -10000 0 0
RAF1 0.035 0.008 -10000 0 0 28 28
JNK cascade 0.009 0.12 0.32 57 -10000 0 57
TSC1 -0.025 0.12 -10000 0 -0.34 56 56
YWHAZ 0.035 0.007 -10000 0 0 21 21
AKT1/RAF1 -0.002 0.13 -10000 0 -0.34 60 60
EP300 0.033 0.011 -10000 0 0 49 49
mol:GDP -0.019 0.12 -10000 0 -0.32 58 58
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 -0.027 0.12 -10000 0 -0.33 59 59
YWHAQ 0.036 0.005 -10000 0 0 9 9
TBC1D4 -0.001 0.022 0.12 14 -10000 0 14
MAP3K5 0.03 0.014 -10000 0 0 90 90
MAPKAP1 0.034 0.009 -10000 0 0 31 31
negative regulation of cell cycle 0.005 0.11 0.41 19 -10000 0 19
YWHAH 0.031 0.013 -10000 0 0 73 73
AKT1S1 -0.019 0.11 -10000 0 -0.31 58 58
CASP9 -0.021 0.11 0.2 3 -0.32 57 60
YWHAB 0.035 0.008 -10000 0 0 24 24
p27Kip1/KPNA1 -0.008 0.13 0.27 3 -0.32 58 61
GBL 0.036 0.006 -10000 0 0 15 15
PDK1/Src/Hsp90 0.047 0.01 -10000 0 -10000 0 0
YWHAE 0.035 0.008 -10000 0 0 27 27
SRC 0.036 0.006 -10000 0 0 14 14
AKT2/p21CIP1 -0.025 0.11 0.23 1 -0.31 44 45
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.015 0.067 -10000 0 -0.44 7 7
CHUK -0.021 0.1 -10000 0 -0.33 46 46
BAD/BCL-XL 0.004 0.12 -10000 0 -0.32 56 56
mTORC2 0.06 0.031 -10000 0 -0.12 8 8
AKT2 0.014 0.004 -10000 0 -10000 0 0
FOXO1-3a-4/14-3-3 family -0.007 0.13 -10000 0 -0.44 25 25
PDPK1 0.036 0.004 -10000 0 0 7 7
MDM2 -0.017 0.12 -10000 0 -0.32 56 56
MAPKKK cascade 0.002 0.13 0.33 60 -10000 0 60
MDM2/Cbp/p300 0.015 0.13 0.27 1 -0.31 55 56
TSC1/TSC2 -0.03 0.13 0.26 8 -0.34 59 67
proteasomal ubiquitin-dependent protein catabolic process 0.014 0.12 0.26 1 -0.3 55 56
glucose import -0.008 0.022 0.2 3 -10000 0 3
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.012 0.082 -10000 0 -0.33 9 9
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 -0.008 0.022 0.2 3 -10000 0 3
GSK3A -0.019 0.11 0.26 5 -0.32 53 58
FOXO1 -0.019 0.11 -10000 0 -0.31 58 58
GSK3B -0.024 0.12 -10000 0 -0.34 57 57
SFN 0.031 0.013 -10000 0 0 78 78
G1/S transition of mitotic cell cycle -0.028 0.12 0.25 8 -0.33 58 66
p27Kip1/14-3-3 family 0.008 0.11 -10000 0 -0.53 13 13
PRKACA 0.035 0.008 -10000 0 0 25 25
KPNA1 0.035 0.008 -10000 0 0 27 27
HSP90AA1 0 0 -10000 0 -10000 0 0
YWHAG 0 0 -10000 0 -10000 0 0
RHEB 0.024 0.017 -10000 0 0 173 173
CREBBP 0.036 0.005 -10000 0 0 8 8
Regulation of p38-alpha and p38-beta

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.047 0.011 -10000 0 -10000 0 0
response to insulin stimulus 0 0 -10000 0 -10000 0 0
RIPK1 0.035 0.007 -10000 0 0 20 20
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.036 0.004 -10000 0 0 6 6
mol:GTP 0 0 -10000 0 -10000 0 0
MAP2K4 0.035 0.007 -10000 0 0 19 19
RAC1-CDC42/GTP/PAK family 0.002 0.048 -10000 0 -0.14 41 41
response to UV 0 0 -10000 0 -10000 0 0
YES1 0.034 0.01 -10000 0 0 41 41
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
MAP3K3 0.036 0.004 -10000 0 0 7 7
FYN 0.03 0.014 -10000 0 0 90 90
MAP3K12 0.036 0.005 -10000 0 0 9 9
FGR 0.033 0.011 -10000 0 0 54 54
p38 alpha/TAB1 0.018 0.11 0.18 4 -0.26 41 45
PRKG1 0.026 0.016 -10000 0 0 141 141
DUSP8 0.034 0.01 -10000 0 0 39 39
PGK/cGMP/p38 alpha 0.004 0.098 0.17 1 -0.25 40 41
apoptosis 0.017 0.1 0.18 4 -0.24 41 45
RAL/GTP 0.026 0.038 -10000 0 -0.12 20 20
LYN 0.031 0.013 -10000 0 0 74 74
DUSP1 0.031 0.013 -10000 0 0 77 77
PAK1 0.036 0.006 -10000 0 0 15 15
SRC 0.036 0.006 -10000 0 0 14 14
RAC1/OSM/MEKK3/MKK3 0.044 0.037 -10000 0 -0.11 5 5
TRAF6 0.036 0.005 -10000 0 0 10 10
RAC1 0.024 0.017 -10000 0 0 173 173
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
mol:cGMP 0 0 -10000 0 -10000 0 0
CCM2 0 0 -10000 0 -10000 0 0
RAC1-CDC42/GTP 0.03 0.028 -10000 0 -0.12 5 5
MAPK11 -0.002 0.13 0.19 6 -0.32 44 50
BLK 0.035 0.007 -10000 0 0 17 17
HCK 0.027 0.016 -10000 0 0 128 128
MAP2K3 0.036 0.005 -10000 0 0 10 10
DUSP16 0 0 -10000 0 -10000 0 0
DUSP10 0.033 0.011 -10000 0 0 48 48
TRAF6/MEKK3 0.045 0.01 -10000 0 -0.1 1 1
MAP3K7IP1 0.034 0.009 -10000 0 0 35 35
MAPK14 0.009 0.11 0.17 6 -0.26 43 49
positive regulation of innate immune response 0.001 0.14 0.21 6 -0.34 47 53
LCK 0.035 0.007 -10000 0 0 17 17
p38alpha-beta/MKP7 -0.001 0.14 0.19 8 -0.33 47 55
p38alpha-beta/MKP5 0.014 0.14 0.23 5 -0.34 40 45
PGK/cGMP 0.02 0.012 -10000 0 -10000 0 0
PAK2 0.035 0.007 -10000 0 0 20 20
p38alpha-beta/MKP1 0.005 0.14 0.23 5 -0.33 48 53
CDC42 0.035 0.008 -10000 0 0 24 24
RALB 0.035 0.007 -10000 0 0 17 17
RALA 0.024 0.018 -10000 0 0 180 180
PAK3 0.027 0.016 -10000 0 0 139 139
IGF1 pathway

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.035 0.007 -10000 0 0 17 17
PTK2 0.034 0.009 -10000 0 0 32 32
CRKL -0.017 0.044 0.097 27 -0.15 24 51
GRB2/SOS1/SHC 0.04 0.031 -10000 0 -0.12 14 14
HRAS 0.034 0.009 -10000 0 0 32 32
IRS1/Crk 0.018 0.047 -10000 0 -0.14 35 35
IGF-1R heterotetramer/IGF1/PTP1B 0.052 0.055 -10000 0 -0.14 29 29
AKT1 -0.034 0.075 0.15 28 -0.22 30 58
BAD -0.038 0.072 0.15 24 -0.22 29 53
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.018 0.045 0.1 28 -0.16 24 52
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.025 0.048 0.16 1 -0.14 29 30
RAF1 -0.032 0.14 -10000 0 -0.55 28 28
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.046 0.054 0.17 1 -0.14 30 31
YWHAZ 0.035 0.007 -10000 0 0 21 21
IGF-1R heterotetramer/IGF1/IRS1 0.033 0.049 0.17 1 -0.16 24 25
PIK3CA 0.031 0.013 -10000 0 0 80 80
RPS6KB1 -0.033 0.071 0.16 31 -0.2 22 53
GNB2L1 0.036 0.002 -10000 0 0 2 2
positive regulation of MAPKKK cascade -0.033 0.12 0.23 3 -0.43 28 31
PXN 0.036 0.004 -10000 0 0 7 7
PIK3R1 0.032 0.012 -10000 0 0 63 63
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
HRAS/GTP 0.015 0.054 -10000 0 -0.14 43 43
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.066 0.057 -10000 0 -0.12 34 34
IGF-1R heterotetramer 0.036 0.014 0.092 1 -0.034 1 2
IGF-1R heterotetramer/IGF1/IRS/Nck 0.048 0.06 0.18 1 -0.14 36 37
Crk/p130 Cas/Paxillin 0.038 0.056 0.2 3 -0.13 35 38
IGF1R 0.036 0.014 0.092 1 -0.034 1 2
IGF1 0.033 0.026 0.092 1 -0.055 33 34
IRS2/Crk -0.03 0.057 0.1 19 -0.18 32 51
PI3K 0.039 0.087 0.2 1 -0.14 78 79
apoptosis 0.037 0.076 0.21 30 -0.16 21 51
HRAS/GDP 0.021 0.027 -10000 0 -0.13 15 15
PRKCD 0.004 0.064 0.17 8 -0.21 24 32
RAF1/14-3-3 E -0.012 0.13 0.23 1 -0.48 28 29
BAD/14-3-3 -0.039 0.08 0.17 21 -0.22 30 51
PRKCZ -0.027 0.07 0.15 32 -0.2 22 54
Crk/p130 Cas/Paxillin/FAK1 -0.046 0.072 0.13 26 -0.22 29 55
PTPN1 0.034 0.009 -10000 0 0 30 30
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 0.006 0.06 -10000 0 -0.21 26 26
BCAR1 0 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 0.038 0.07 -10000 0 -0.14 40 40
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0 0 -10000 0 -10000 0 0
IRS1/NCK2 0.027 0.051 0.13 5 -0.14 35 40
GRB10 0.021 0.018 -10000 0 0 220 220
PTPN11 -0.018 0.045 0.1 28 -0.15 24 52
IRS1 0.01 0.042 0.12 5 -0.16 24 29
IRS2 -0.019 0.049 0.1 20 -0.19 24 44
IGF-1R heterotetramer/IGF1 0.039 0.051 0.15 1 -0.17 24 25
GRB2 0.035 0.007 -10000 0 0 17 17
PDPK1 -0.026 0.076 0.17 30 -0.2 22 52
YWHAE 0.035 0.008 -10000 0 0 27 27
PRKD1 -0.002 0.064 0.2 1 -0.24 25 26
SHC1 0.033 0.011 -10000 0 0 52 52
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.03 0.035 -10000 0 -0.14 9 9
CRKL 0.042 0.11 0.28 6 -0.4 21 27
mol:PIP3 -0.009 0.1 -10000 0 -0.79 7 7
AKT1 -0.02 0.092 0.25 1 -0.7 7 8
PTK2B 0.035 0.006 -10000 0 0 16 16
RAPGEF1 0.04 0.11 0.31 7 -0.38 21 28
RANBP10 0.036 0.005 -10000 0 0 10 10
PIK3CA 0.031 0.013 -10000 0 0 80 80
HGF/MET/SHIP2 0.042 0.038 -10000 0 -0.12 2 2
MAP3K5 0.04 0.11 0.29 5 -0.38 20 25
HGF/MET/CIN85/CBL/ENDOPHILINS 0.04 0.035 -10000 0 -10000 0 0
AP1 0.035 0.079 0.15 97 -0.15 44 141
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.033 0.011 -10000 0 0 52 52
apoptosis -0.12 0.36 -10000 0 -0.79 109 109
STAT3 (dimer) 0.011 0.059 -10000 0 -0.28 11 11
GAB1/CRKL/SHP2/PI3K 0.058 0.13 0.31 2 -0.4 21 23
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK 0.059 0.12 0.29 3 -0.39 21 24
PTPN11 0.036 0.005 -10000 0 0 11 11
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.035 0.007 -10000 0 0 19 19
PTEN 0.026 0.017 -10000 0 0 148 148
ELK1 0.12 0.18 0.36 169 -10000 0 169
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 0.012 0.034 0.16 1 -0.17 6 7
PAK1 -0.024 0.088 -10000 0 -0.68 7 7
HGF/MET/RANBP10 0.042 0.037 -10000 0 -10000 0 0
HRAS 0.011 0.083 -10000 0 -0.47 11 11
DOCK1 0.031 0.11 0.28 5 -0.39 20 25
GAB1 0.045 0.12 -10000 0 -0.41 21 21
CRK 0.043 0.11 0.29 3 -0.4 21 24
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP 0.018 0.069 -10000 0 -0.42 10 10
JUN 0.034 0.01 -10000 0 0 40 40
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET 0.01 0.017 -10000 0 -0.12 1 1
PIK3R1 0.032 0.012 -10000 0 0 63 63
cell morphogenesis 0.024 0.11 0.28 21 -0.32 14 35
GRB2/SHC 0.077 0.065 0.17 115 -0.12 2 117
FOS 0.025 0.017 -10000 0 0 158 158
GLMN 0.004 0.004 0.068 2 -10000 0 2
cell motility 0.12 0.18 0.36 169 -10000 0 169
HGF/MET/MUC20 0.029 0.024 -10000 0 -10000 0 0
cell migration 0.075 0.063 0.17 115 -0.12 2 117
GRB2 0.035 0.007 -10000 0 0 17 17
CBL 0.036 0.004 -10000 0 0 7 7
MET/RANBP10 0.033 0.026 -10000 0 -10000 0 0
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.013 0.048 -10000 0 -0.19 20 20
MET/MUC20 0.017 0.013 -10000 0 -10000 0 0
RAP1B 0.039 0.11 0.3 7 -0.36 21 28
RAP1A 0.034 0.11 0.3 8 -0.36 20 28
HGF/MET/RANBP9 0.04 0.042 -10000 0 -0.12 8 8
RAF1 0.038 0.1 0.31 1 -0.45 13 14
STAT3 0.009 0.058 -10000 0 -0.29 11 11
cell proliferation 0.039 0.081 0.24 14 -0.28 9 23
RPS6KB1 0.014 0.018 -10000 0 -10000 0 0
MAPK3 0.084 0.17 0.4 29 -10000 0 29
MAPK1 0.12 0.22 0.59 50 -10000 0 50
RANBP9 0.035 0.007 -10000 0 0 18 18
MAPK8 -0.048 0.16 0.27 1 -0.41 30 31
SRC 0.007 0.046 -10000 0 -0.26 6 6
PI3K 0.061 0.074 0.17 95 -0.16 9 104
MET/Glomulin 0.016 0.026 -10000 0 -0.087 17 17
SOS1 0 0 -10000 0 -10000 0 0
MAP2K1 0.029 0.1 0.29 1 -0.43 14 15
MET 0.023 0.018 -10000 0 0 191 191
MAP4K1 0.048 0.11 0.3 4 -0.38 20 24
PTK2 0.034 0.009 -10000 0 0 32 32
MAP2K2 0.038 0.11 0.3 14 -0.42 12 26
BAD -0.027 0.088 -10000 0 -0.63 8 8
MAP2K4 0.033 0.11 0.27 9 -0.35 20 29
SHP2/GRB2/SOS1/GAB1 0.016 0.085 -10000 0 -0.35 19 19
INPPL1 0.036 0.006 -10000 0 0 12 12
PXN 0.036 0.004 -10000 0 0 7 7
SH3KBP1 0 0 -10000 0 -10000 0 0
HGS 0.001 0.018 0.076 15 -0.12 1 16
PLCgamma1/PKC 0.025 0.013 -10000 0 -0.13 3 3
HGF 0.024 0.017 -10000 0 0 177 177
RASA1 0.034 0.009 -10000 0 0 32 32
NCK1 0.035 0.008 -10000 0 0 27 27
PTPRJ 0.036 0.005 -10000 0 0 11 11
NCK/PLCgamma1 0.083 0.059 0.17 120 -0.12 1 121
PDPK1 -0.012 0.096 0.29 1 -0.74 7 8
HGF/MET/SHIP 0.029 0.024 -10000 0 -10000 0 0
Alternative NF-kappaB pathway

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.036 0.028 -9999 0 -0.14 2 2
FBXW11 0.035 0.008 -9999 0 0 25 25
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.035 0.008 -9999 0 0 25 25
CHUK 0.025 0.017 -9999 0 0 163 163
NF kappa B2 p100/RelB 0.066 0.059 -9999 0 -0.12 10 10
NFKB1 0.035 0.007 -9999 0 0 18 18
MAP3K14 0.036 0.006 -9999 0 0 13 13
NF kappa B1 p50/RelB 0.048 0.024 -9999 0 -0.14 5 5
RELB 0.034 0.009 -9999 0 0 32 32
NFKB2 0.025 0.017 -9999 0 0 158 158
NF kappa B2 p52/RelB 0.033 0.023 -9999 0 -10000 0 0
regulation of B cell activation 0.032 0.023 -9999 0 -10000 0 0
IFN-gamma pathway

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.05 0.073 -10000 0 -0.12 37 37
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
CRKL 0.035 0.009 -10000 0 0 29 29
STAT1 (dimer)/Cbp/p300 0.022 0.083 0.27 5 -0.22 17 22
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.042 0.062 -10000 0 -0.14 39 39
antigen processing and presentation of peptide antigen via MHC class I -0.025 0.079 0.12 5 -0.18 65 70
CaM/Ca2+ 0.046 0.078 -10000 0 -0.14 37 37
RAP1A 0.036 0.005 -10000 0 0 11 11
STAT1 (dimer)/SHP2 -0.022 0.059 0.16 17 -0.18 9 26
AKT1 -0.033 0.084 0.27 5 -0.23 30 35
MAP2K1 -0.028 0.056 0.21 5 -0.22 6 11
MAP3K11 -0.022 0.059 0.26 4 -0.19 5 9
IFNGR1 0.031 0.019 -10000 0 -0.036 19 19
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.028 0.12 -10000 0 -0.3 62 62
Rap1/GTP -0.039 0.036 0.049 1 -0.16 7 8
CRKL/C3G 0.05 0.015 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.064 0.076 -10000 0 -0.13 35 35
CEBPB -0.009 0.12 0.35 3 -0.44 19 22
STAT3 0.034 0.01 -10000 0 0 37 37
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 0.061 0.089 -10000 0 -0.74 3 3
STAT1 -0.024 0.06 0.25 5 -0.18 9 14
CALM1 0.033 0.011 -10000 0 0 54 54
IFN-gamma (dimer) 0.03 0.021 -10000 0 -0.037 38 38
PIK3CA 0.031 0.013 -10000 0 0 80 80
STAT1 (dimer)/PIAS1 -0.025 0.07 0.24 6 -0.21 15 21
CEBPB/PTGES2/Cbp/p300 0.008 0.09 -10000 0 -0.3 21 21
mol:Ca2+ 0.046 0.07 -10000 0 -0.12 37 37
MAPK3 0.006 0.079 0.34 1 -0.68 2 3
STAT1 (dimer) -0.027 0.11 0.19 7 -0.26 55 62
MAPK1 -0.041 0.2 -10000 0 -0.75 35 35
JAK2 0.027 0.022 -10000 0 -0.037 34 34
PIK3R1 0.032 0.012 -10000 0 0 63 63
JAK1 0.033 0.017 -10000 0 -0.036 17 17
CAMK2D 0 0 -10000 0 -10000 0 0
DAPK1 -0.001 0.096 0.32 3 -0.44 9 12
SMAD7 -0.009 0.06 0.16 22 -0.15 16 38
CBL/CRKL/C3G 0.018 0.071 0.27 4 -0.19 4 8
PI3K 0.026 0.094 -10000 0 -0.21 28 28
IFNG 0.03 0.021 -10000 0 -0.037 38 38
apoptosis 0.012 0.086 0.34 2 -0.41 8 10
CAMK2G 0.024 0.018 -10000 0 0 179 179
STAT3 (dimer) 0.034 0.01 -10000 0 0 37 37
CAMK2A 0.036 0.005 -10000 0 0 10 10
CAMK2B 0.017 0.018 -10000 0 0 272 272
FRAP1 -0.039 0.077 0.25 4 -0.22 31 35
PRKCD -0.032 0.08 0.32 4 -0.22 19 23
RAP1B 0 0 -10000 0 -10000 0 0
negative regulation of cell growth -0.025 0.079 0.12 5 -0.18 65 70
PTPN2 0.035 0.007 -10000 0 0 18 18
EP300 0.034 0.011 -10000 0 0 49 49
IRF1 -0.035 0.058 0.21 3 -0.28 12 15
STAT1 (dimer)/PIASy -0.025 0.065 0.26 5 -0.19 6 11
SOCS1 0.019 0.083 -10000 0 -1 3 3
mol:GDP -0.021 0.066 0.17 21 -0.18 4 25
CASP1 -0.019 0.073 0.18 15 -0.16 62 77
PTGES2 0.035 0.007 -10000 0 0 20 20
IRF9 -0.002 0.044 0.12 15 -0.13 15 30
mol:PI-3-4-5-P3 0.013 0.082 -10000 0 -0.19 31 31
RAP1/GDP -0.031 0.052 0.11 17 -0.18 5 22
CBL -0.022 0.058 0.25 4 -0.19 4 8
MAP3K1 -0.023 0.056 0.25 3 -0.19 4 7
PIAS1 0.035 0.008 -10000 0 0 27 27
PIAS4 0.035 0.008 -10000 0 0 27 27
antigen processing and presentation of peptide antigen via MHC class II -0.025 0.079 0.12 5 -0.18 65 70
PTPN11 -0.016 0.059 0.16 25 -0.18 6 31
CREBBP 0.037 0.005 -10000 0 0 8 8
RAPGEF1 0.035 0.007 -10000 0 0 19 19
PDGFR-beta signaling pathway

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate 0.028 0.11 0.32 9 -0.32 18 27
PDGFB-D/PDGFRB/SLAP 0.018 0.072 -10000 0 -0.15 71 71
PDGFB-D/PDGFRB/APS/CBL 0.045 0.022 -10000 0 -0.12 7 7
AKT1 -0.026 0.089 0.26 13 -0.24 15 28
mol:PI-4-5-P2 0 0.001 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate 0.019 0.1 0.29 9 -0.32 22 31
PIK3CA 0.031 0.013 -10000 0 0 80 80
FGR 0.006 0.1 0.27 3 -0.5 13 16
mol:Ca2+ 0.011 0.1 0.26 8 -0.37 20 28
MYC 0.01 0.26 0.4 21 -0.67 51 72
SHC1 0.033 0.011 -10000 0 0 52 52
HRAS/GDP 0.012 0.066 0.17 26 -0.18 13 39
LRP1/PDGFRB/PDGFB 0.048 0.055 -10000 0 -0.13 32 32
GRB10 0.021 0.018 -10000 0 0 220 220
PTPN11 0.036 0.005 -10000 0 0 11 11
GO:0007205 0.011 0.1 0.26 8 -0.37 20 28
PTEN 0.026 0.017 -10000 0 0 148 148
GRB2 0.035 0.007 -10000 0 0 17 17
GRB7 0.036 0.006 -10000 0 0 14 14
PDGFB-D/PDGFRB/SHP2 0.047 0.033 -10000 0 -0.14 13 13
PDGFB-D/PDGFRB/GRB10 0.021 0.049 -10000 0 -0.14 30 30
cell cycle arrest 0.017 0.072 -10000 0 -0.15 71 71
HRAS 0.034 0.009 -10000 0 0 32 32
HIF1A -0.03 0.081 0.23 14 -0.25 13 27
GAB1 0.006 0.12 0.28 9 -0.37 30 39
mol:GTP 0 0 -10000 0 -10000 0 0
DNM2 0.005 0.12 0.3 14 -0.33 29 43
PDGFB-D/PDGFRB 0.056 0.053 0.19 1 -0.14 14 15
mol:GDP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.044 0.04 -10000 0 -0.14 20 20
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB 0.025 0.12 0.29 8 -0.3 32 40
positive regulation of MAPKKK cascade 0.047 0.033 -10000 0 -0.14 13 13
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 0.011 0.1 0.26 8 -0.38 20 28
E5 -0.001 0.002 -10000 0 -10000 0 0
CSK 0.034 0.011 -10000 0 -0.009 29 29
PDGFB-D/PDGFRB/GRB7 0.05 0.022 -10000 0 -0.14 4 4
SHB 0.033 0.011 -10000 0 0 51 51
BLK 0.012 0.077 0.3 2 -0.43 7 9
PTPN2 0.032 0.018 -10000 0 -0.019 49 49
PDGFB-D/PDGFRB/SNX15 0.049 0.025 -10000 0 -0.14 7 7
BCAR1 0 0 -10000 0 -10000 0 0
VAV2 -0.006 0.15 0.29 13 -0.41 42 55
CBL 0.036 0.004 -10000 0 0 7 7
PDGFB-D/PDGFRB/DEP1 0.049 0.026 -10000 0 -0.14 7 7
LCK 0.017 0.06 0.26 4 -0.35 2 6
PDGFRB 0.031 0.021 0.064 2 -0.019 71 73
ACP1 0.035 0.007 -10000 0 0 18 18
HCK -0.043 0.18 0.22 1 -0.5 61 62
ABL1 0.002 0.11 0.26 9 -0.34 29 38
PDGFB-D/PDGFRB/CBL 0.006 0.13 0.28 6 -0.43 27 33
PTPN1 0.032 0.018 -10000 0 -0.015 60 60
SNX15 0.036 0.004 -10000 0 0 6 6
STAT3 0.034 0.01 -10000 0 0 37 37
STAT1 0.034 0.01 -10000 0 0 40 40
cell proliferation 0.018 0.24 0.38 25 -0.6 51 76
SLA 0.027 0.016 -10000 0 0 134 134
actin cytoskeleton reorganization -0.018 0.067 0.2 30 -0.19 7 37
SRC 0.017 0.052 0.35 1 -10000 0 1
PI3K -0.047 0.044 -10000 0 -0.18 31 31
PDGFB-D/PDGFRB/GRB7/SHC 0.061 0.037 -10000 0 -0.12 10 10
SH2B2 0 0 -10000 0 -10000 0 0
PLCgamma1/SPHK1 0.019 0.1 0.29 9 -0.33 22 31
LYN -0.035 0.16 -10000 0 -0.47 53 53
LRP1 0.031 0.013 -10000 0 0 71 71
SOS1 0 0 -10000 0 -10000 0 0
STAT5B 0.036 0.004 -10000 0 0 5 5
STAT5A 0.036 0.004 -10000 0 0 5 5
NCK1-2/p130 Cas 0.066 0.065 -10000 0 -0.14 25 25
SPHK1 0.033 0.011 0.058 1 0 50 51
EDG1 0.034 0.011 0.058 1 0 45 46
mol:DAG 0.011 0.1 0.26 8 -0.38 20 28
PLCG1 0.011 0.1 0.26 8 -0.38 20 28
NHERF/PDGFRB 0.062 0.036 -10000 0 -0.12 11 11
YES1 -0.009 0.13 0.23 1 -0.52 25 26
cell migration 0.061 0.036 -10000 0 -0.12 11 11
SHC/Grb2/SOS1 0.068 0.061 -10000 0 -0.13 20 20
SLC9A3R2 0.036 0.005 -10000 0 0 9 9
SLC9A3R1 0.034 0.01 -10000 0 0 37 37
NHERF1-2/PDGFRB/PTEN 0.06 0.052 -10000 0 -0.11 13 13
FYN -0.055 0.19 0.22 1 -0.45 81 82
DOK1 -0.017 0.053 0.17 27 -10000 0 27
HRAS/GTP 0.021 0.027 -10000 0 -0.13 15 15
PDGFB 0.034 0.01 -10000 0 0 37 37
RAC1 0.031 0.19 0.32 35 -0.43 47 82
PRKCD -0.015 0.053 0.18 26 -10000 0 26
FER -0.016 0.054 0.18 25 -10000 0 25
MAPKKK cascade -0.014 0.061 0.15 44 -0.18 5 49
RASA1 -0.015 0.055 0.18 26 -0.21 3 29
NCK1 0.035 0.008 -10000 0 0 27 27
NCK2 0.035 0.007 -10000 0 0 17 17
p62DOK/Csk -0.014 0.063 0.18 31 -0.2 3 34
PDGFB-D/PDGFRB/SHB 0.045 0.027 -10000 0 -0.14 5 5
chemotaxis 0.002 0.11 0.26 9 -0.33 29 38
STAT1-3-5/STAT1-3-5 0.062 0.072 -10000 0 -0.14 30 30
Bovine Papilomavirus E5/PDGFRB 0.02 0.024 -10000 0 -0.14 7 7
PTPRJ 0.036 0.005 -10000 0 0 11 11
a4b1 and a4b7 Integrin signaling

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.027 0.016 -9999 0 0 138 138
ITGB7 0.036 0.005 -9999 0 0 11 11
ITGA4 0.036 0.006 -9999 0 0 13 13
alpha4/beta7 Integrin 0.052 0.011 -9999 0 -9999 0 0
alpha4/beta1 Integrin 0.039 0.025 -9999 0 -9999 0 0
S1P1 pathway

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.017 0.051 -10000 0 -0.18 28 28
PDGFRB 0.036 0.009 -10000 0 -0.001 28 28
SPHK1 0.017 0.04 -10000 0 -0.76 1 1
mol:S1P 0.019 0.042 -10000 0 -0.68 1 1
S1P1/S1P/Gi -0.001 0.14 0.25 12 -0.47 27 39
GNAO1 0.032 0.015 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/PLCgamma1 0.027 0.14 0.25 18 -0.39 28 46
PLCG1 -0.005 0.13 0.24 15 -0.42 28 43
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.036 0.009 -10000 0 -0.001 28 28
GNAI2 0.036 0.012 -10000 0 0 43 43
GNAI3 0.037 0.007 -10000 0 0 15 15
GNAI1 0.018 0.019 -10000 0 0 263 263
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 0.007 0.073 0.12 5 -0.27 27 32
S1P1/S1P 0.024 0.077 0.21 4 -0.28 17 21
negative regulation of cAMP metabolic process 0 0.14 0.25 13 -0.46 27 40
MAPK3 0.002 0.14 0.29 16 -0.46 24 40
calcium-dependent phospholipase C activity 0 0.003 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.019 -10000 0 -0.13 5 5
RhoA/GDP 0.024 0.019 -10000 0 -0.13 7 7
KDR 0.027 0.034 0.093 1 -0.13 18 19
PLCB2 0.036 0.089 0.21 26 -0.26 17 43
RAC1 0.024 0.017 -10000 0 0 173 173
RhoA/GTP 0.018 0.066 -10000 0 -0.25 17 17
receptor internalization 0.023 0.073 0.2 4 -0.26 17 21
PTGS2 0.032 0.15 0.36 6 -0.48 15 21
Rac1/GTP 0.009 0.057 -10000 0 -0.28 11 11
RHOA 0.035 0.007 -10000 0 0 18 18
VEGFA -0.001 0.021 -10000 0 -0.098 23 23
negative regulation of T cell proliferation 0 0.14 0.25 13 -0.46 27 40
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ 0.032 0.015 -10000 0 -10000 0 0
MAPK1 0.003 0.14 0.29 13 -0.49 21 34
S1P1/S1P/PDGFB-D/PDGFRB 0.052 0.1 0.24 17 -0.29 20 37
ABCC1 0.036 0.008 -10000 0 0 19 19
Plasma membrane estrogen receptor signaling

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.053 0.036 -10000 0 -0.097 20 20
ER alpha/Gai/GDP/Gbeta gamma -0.038 0.17 -10000 0 -0.52 41 41
AKT1 -0.053 0.23 -10000 0 -0.68 49 49
PIK3CA 0.031 0.013 -10000 0 0 80 80
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.046 0.24 -10000 0 -0.7 48 48
mol:Ca2+ 0.001 0.044 0.17 4 -0.25 3 7
IGF1R 0.033 0.012 -10000 0 0 57 57
E2/ER alpha (dimer)/Striatin 0.046 0.012 -10000 0 -10000 0 0
SHC1 0.033 0.011 -10000 0 0 52 52
apoptosis 0.052 0.22 0.63 51 -10000 0 51
RhoA/GTP -0.041 0.038 -10000 0 -0.13 48 48
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.012 0.15 -10000 0 -0.39 46 46
regulation of stress fiber formation 0.038 0.058 0.18 20 -0.18 8 28
E2/ERA-ERB (dimer) 0.045 0.015 -10000 0 -10000 0 0
KRAS 0.034 0.009 -10000 0 0 35 35
G13/GTP 0.043 0.013 -10000 0 -10000 0 0
pseudopodium formation -0.038 0.058 0.18 8 -0.18 20 28
E2/ER alpha (dimer)/PELP1 0.044 0.023 -10000 0 -0.11 7 7
GRB2 0.035 0.007 -10000 0 0 17 17
GNG2 0 0 -10000 0 -10000 0 0
GNAO1 0.03 0.014 -10000 0 0 87 87
HRAS 0.034 0.009 -10000 0 0 32 32
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.012 0.16 -10000 0 -0.44 44 44
E2/ER beta (dimer) 0.025 0.006 -10000 0 -10000 0 0
mol:GDP 0.004 0.057 -10000 0 -0.19 27 27
mol:NADP -0.012 0.16 -10000 0 -0.44 44 44
PIK3R1 0.032 0.012 -10000 0 0 63 63
mol:IP3 0.002 0.042 0.17 4 -0.33 1 5
IGF-1R heterotetramer 0.032 0.012 -10000 0 0 57 57
PLCB1 0.01 0.04 -10000 0 -0.33 1 1
PLCB2 0.008 0.04 -10000 0 -0.33 1 1
IGF1 0.035 0.008 -10000 0 0 23 23
mol:L-citrulline -0.012 0.16 -10000 0 -0.44 44 44
RHOA 0.035 0.007 -10000 0 0 18 18
Gai/GDP -0.066 0.24 -10000 0 -0.64 69 69
JNK cascade 0.025 0.006 -10000 0 -10000 0 0
BCAR1 0 0 -10000 0 -10000 0 0
ESR2 0.034 0.009 -10000 0 0 31 31
GNAQ 0.034 0.009 -10000 0 0 31 31
ESR1 0.035 0.009 -10000 0 0 29 29
Gq family/GDP/Gbeta gamma -0.003 0.15 -10000 0 -0.47 37 37
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.015 0.14 -10000 0 -0.68 17 17
E2/ER alpha (dimer)/PELP1/Src/p52 SHC 0.001 0.16 0.25 2 -0.39 46 48
GNAZ 0.031 0.013 -10000 0 0 81 81
E2/ER alpha (dimer) 0.026 0.006 -10000 0 -10000 0 0
STRN 0.036 0.003 -10000 0 0 3 3
GNAL 0.036 0.006 -10000 0 0 13 13
PELP1 0.035 0.007 -10000 0 0 17 17
MAPK11 -0.016 0.006 -10000 0 -10000 0 0
GNAI2 0.034 0.01 -10000 0 0 43 43
GNAI3 0.036 0.006 -10000 0 0 15 15
GNAI1 0.018 0.018 -10000 0 0 263 263
HBEGF -0.02 0.18 0.31 10 -0.48 42 52
cAMP biosynthetic process 0.037 0.015 -10000 0 -10000 0 0
SRC -0.041 0.16 0.2 5 -0.48 44 49
PI3K 0.019 0.075 -10000 0 -0.16 73 73
GNB1 0.035 0.007 -10000 0 0 20 20
G13/GDP/Gbeta gamma 0.022 0.068 -10000 0 -0.17 34 34
SOS1 0 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.025 0.12 -10000 0 -0.33 44 44
Gs family/GTP 0.047 0.019 -10000 0 -10000 0 0
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.042 0.063 -10000 0 -0.13 53 53
vasodilation -0.01 0.16 -10000 0 -0.42 44 44
mol:DAG 0.002 0.042 0.17 4 -0.33 1 5
Gs family/GDP/Gbeta gamma 0.004 0.062 -10000 0 -0.18 30 30
MSN -0.039 0.057 0.17 7 -0.19 21 28
Gq family/GTP 0.022 0.043 -10000 0 -0.34 1 1
mol:PI-3-4-5-P3 -0.045 0.23 -10000 0 -0.67 48 48
NRAS 0.032 0.012 -10000 0 0 63 63
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.01 0.16 0.42 44 -10000 0 44
GRB2/SOS1 0.024 0.02 -10000 0 -0.13 8 8
RhoA/GDP 0.018 0.067 -10000 0 -0.19 27 27
NOS3 -0.014 0.17 -10000 0 -0.47 44 44
GNA11 0.033 0.011 -10000 0 0 54 54
MAPKKK cascade 0 0.15 -10000 0 -0.47 36 36
E2/ER alpha (dimer)/PELP1/Src -0.003 0.16 0.27 2 -0.41 45 47
ruffle organization -0.038 0.058 0.18 8 -0.18 20 28
ROCK2 -0.034 0.061 0.2 7 -0.19 12 19
GNA14 0.034 0.009 -10000 0 0 30 30
GNA15 0.033 0.012 -10000 0 0 57 57
GNA13 0.035 0.007 -10000 0 0 19 19
MMP9 -0.025 0.17 0.37 4 -0.46 45 49
MMP2 -0.025 0.17 0.24 7 -0.46 46 53
Caspase cascade in apoptosis

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.007 0.088 -10000 0 -0.3 22 22
ACTA1 -0.037 0.092 0.16 1 -0.3 34 35
NUMA1 -0.002 0.085 -10000 0 -0.31 20 20
SPTAN1 -0.044 0.092 0.2 5 -0.29 37 42
LIMK1 0.011 0.11 0.19 79 -0.34 16 95
BIRC3 0.031 0.013 -10000 0 0 81 81
BIRC2 0.036 0.005 -10000 0 0 11 11
BAX 0.033 0.01 -10000 0 0 44 44
CASP10 -0.008 0.031 0.082 47 -10000 0 47
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
PTK2 -0.01 0.092 -10000 0 -0.3 28 28
DIABLO 0.036 0.004 -10000 0 0 6 6
apoptotic nuclear changes -0.044 0.092 0.2 5 -0.29 37 42
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.036 0.006 -10000 0 0 12 12
GSN -0.038 0.098 0.2 5 -0.31 35 40
MADD 0.036 0.006 -10000 0 0 15 15
TFAP2A 0.045 0.055 -10000 0 -0.44 5 5
BID 0 0.039 0.11 5 -0.19 16 21
MAP3K1 -0.003 0.051 -10000 0 -0.39 5 5
TRADD 0.036 0.005 -10000 0 0 11 11
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.05 0.018 -10000 0 -0.14 2 2
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.042 0.099 0.2 12 -0.3 37 49
CASP9 0.034 0.009 -10000 0 0 33 33
DNA repair 0.034 0.071 0.22 32 -10000 0 32
neuron apoptosis 0.017 0.12 -10000 0 -0.62 15 15
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.025 0.088 -10000 0 -0.31 28 28
APAF1 0.036 0.003 -10000 0 0 4 4
CASP6 0.027 0.11 -10000 0 -0.84 6 6
TRAF2 0.036 0.006 -10000 0 0 15 15
ICAD/CAD -0.047 0.084 0.22 1 -0.3 32 33
CASP7 -0.079 0.11 -10000 0 -0.24 143 143
KRT18 0.027 0.051 -10000 0 -0.46 4 4
apoptosis -0.033 0.092 -10000 0 -0.39 13 13
DFFA -0.043 0.087 0.17 1 -0.3 34 35
DFFB -0.042 0.085 -10000 0 -0.3 32 32
PARP1 -0.035 0.071 -10000 0 -0.22 32 32
actin filament polymerization -0.017 0.11 0.32 16 -0.18 79 95
TNF 0.036 0.003 -10000 0 0 4 4
CYCS 0.016 0.039 0.18 3 -0.24 3 6
SATB1 0.018 0.11 -10000 0 -0.73 6 6
SLK -0.026 0.085 -10000 0 -0.29 33 33
p15 BID/BAX 0.002 0.06 0.15 2 -0.16 44 46
CASP2 0.062 0.1 0.22 131 -0.26 5 136
JNK cascade 0.003 0.051 0.38 5 -10000 0 5
CASP3 -0.04 0.092 -10000 0 -0.3 37 37
LMNB2 0.062 0.092 0.23 13 -0.36 4 17
RIPK1 0.035 0.007 -10000 0 0 20 20
CASP4 0.03 0.014 -10000 0 0 92 92
Mammalian IAPs/DIABLO 0.058 0.034 -10000 0 -0.15 6 6
negative regulation of DNA binding 0.045 0.054 -10000 0 -0.43 5 5
stress fiber formation -0.036 0.085 -10000 0 -0.29 33 33
GZMB -0.005 0.033 0.092 47 -10000 0 47
CASP1 -0.011 0.066 -10000 0 -0.2 55 55
LMNB1 0.044 0.13 0.23 14 -0.38 16 30
APP 0.017 0.12 -10000 0 -0.63 15 15
TNFRSF1A 0.032 0.012 -10000 0 0 64 64
response to stress 0 0 -10000 0 -10000 0 0
CASP8 -0.011 0.002 0 13 -10000 0 13
VIM -0.033 0.095 0.22 1 -0.36 18 19
LMNA 0.067 0.088 0.23 14 -0.36 2 16
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.018 0.056 0.16 1 -0.28 7 8
LRDD 0.035 0.007 -10000 0 0 20 20
SREBF1 -0.043 0.088 0.18 1 -0.3 34 35
APAF-1/Caspase 9 0.014 0.1 -10000 0 -0.61 12 12
nuclear fragmentation during apoptosis -0.002 0.084 -10000 0 -0.3 20 20
CFL2 0.017 0.11 0.18 79 -0.32 16 95
GAS2 -0.033 0.092 0.19 3 -0.3 32 35
positive regulation of apoptosis 0.062 0.1 0.22 28 -0.4 6 34
PRF1 0.023 0.018 -10000 0 0 192 192
ErbB4 signaling events

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF 0.02 0.13 -10000 0 -0.63 18 18
epithelial cell differentiation -0.008 0.14 -10000 0 -0.65 18 18
ITCH 0.031 0.031 0.11 1 -0.1 22 23
WWP1 -0.021 0.22 -10000 0 -1.1 18 18
FYN 0.03 0.014 -10000 0 0 90 90
EGFR 0.009 0.016 -10000 0 0 381 381
PRL 0.036 0.006 -10000 0 0 15 15
neuron projection morphogenesis -0.028 0.11 0.24 7 -0.5 19 26
PTPRZ1 0.022 0.018 -10000 0 0 201 201
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0.054 0.12 -10000 0 -0.54 18 18
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta 0.003 0.11 -10000 0 -0.57 18 18
ADAM17 0.031 0.031 -10000 0 -0.096 24 24
ErbB4/ErbB4 0.001 0.14 0.22 7 -0.69 18 25
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.009 0.12 -10000 0 -0.62 18 18
NCOR1 0.035 0.008 -10000 0 0 26 26
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn 0.016 0.12 -10000 0 -0.58 18 18
GRIN2B -0.028 0.11 0.21 3 -0.55 18 21
ErbB4/ErbB2/betacellulin 0.024 0.12 0.22 1 -0.55 18 19
STAT1 0.034 0.01 -10000 0 0 40 40
HBEGF 0.035 0.008 -10000 0 0 23 23
PRLR 0.036 0.004 -10000 0 0 6 6
E4ICDs/ETO2 0.02 0.13 -10000 0 -0.63 18 18
axon guidance -0.032 0.16 -10000 0 -0.78 18 18
NEDD4 0.029 0.031 0.11 1 -0.11 21 22
Prolactin receptor/Prolactin receptor/Prolactin 0.052 0.011 -10000 0 -10000 0 0
CBFA2T3 0.034 0.009 -10000 0 0 30 30
ErbB4/ErbB2/HBEGF 0.023 0.11 0.22 1 -0.55 18 19
MAPK3 -0.021 0.11 0.24 6 -0.52 18 24
STAT1 (dimer) 0.019 0.13 -10000 0 -0.63 18 18
MAPK1 -0.023 0.11 0.26 5 -0.52 19 24
JAK2 0.031 0.014 -10000 0 0 83 83
ErbB4/ErbB2/neuregulin 1 beta 0.003 0.11 0.21 1 -0.55 18 19
NRG1 -0.022 0.021 0.089 5 -0.083 18 23
NRG3 0 0 -10000 0 -10000 0 0
NRG2 0.036 0.005 -10000 0 0 10 10
NRG4 0 0 -10000 0 -10000 0 0
heart development -0.032 0.16 -10000 0 -0.78 18 18
neural crest cell migration 0.003 0.11 0.21 1 -0.54 18 19
ERBB2 -0.021 0.023 0.098 8 -0.083 18 26
WWOX/E4ICDs 0.022 0.13 -10000 0 -0.62 18 18
SHC1 0.033 0.011 -10000 0 0 52 52
ErbB4/EGFR/neuregulin 4 -0.015 0.099 -10000 0 -0.48 18 18
apoptosis -0.004 0.12 0.58 18 -10000 0 18
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.021 0.13 -10000 0 -0.63 18 18
ErbB4/ErbB2/epiregulin 0.023 0.11 -10000 0 -0.55 18 18
ErbB4/ErbB4/betacellulin/betacellulin 0.022 0.13 -10000 0 -0.63 18 18
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.062 0.13 -10000 0 -0.57 18 18
MDM2 0 0.13 0.27 13 -0.6 18 31
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta 0.02 0.1 -10000 0 -0.51 18 18
STAT5A -0.037 0.15 -10000 0 -0.76 18 18
ErbB4/EGFR/neuregulin 1 beta -0.005 0.089 -10000 0 -0.43 18 18
DLG4 0.036 0.005 -10000 0 0 11 11
GRB2/SHC 0.043 0.037 -10000 0 -0.15 14 14
E4ICDs/TAB2/NCoR1 0.029 0.13 -10000 0 -0.62 18 18
STAT5A (dimer) -0.001 0.16 -10000 0 -0.72 18 18
MAP3K7IP2 0.033 0.011 -10000 0 0 46 46
STAT5B (dimer) -0.017 0.16 0.28 1 -0.76 18 19
LRIG1 0.03 0.014 -10000 0 0 85 85
EREG 0.035 0.008 -10000 0 0 23 23
BTC 0.036 0.005 -10000 0 0 9 9
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.032 0.16 -10000 0 -0.79 18 18
ERBB4 0.001 0.14 0.22 7 -0.69 18 25
STAT5B 0.036 0.004 -10000 0 0 5 5
YAP1 -0.071 0.2 -10000 0 -0.49 93 93
GRB2 0.035 0.007 -10000 0 0 17 17
ErbB4/ErbB2/neuregulin 4 0.001 0.11 -10000 0 -0.55 18 18
glial cell differentiation -0.029 0.13 0.62 18 -10000 0 18
WWOX 0.035 0.007 -10000 0 0 17 17
cell proliferation -0.014 0.11 0.23 1 -0.57 18 19
IL4-mediated signaling events

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.058 0.38 0.76 2 -1 26 28
STAT6 (cleaved dimer) -0.07 0.35 -10000 0 -0.94 31 31
IGHG1 -0.015 0.26 0.43 21 -0.78 23 44
IGHG3 -0.068 0.36 0.63 1 -0.92 32 33
AKT1 -0.026 0.27 0.51 5 -0.71 33 38
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 0.014 0.19 0.45 6 -0.55 9 15
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.01 0.26 0.5 5 -0.73 22 27
THY1 -0.13 0.5 0.78 2 -1.2 62 64
MYB 0.032 0.012 -10000 0 0 58 58
HMGA1 0.036 0.005 -10000 0 0 11 11
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.003 0.26 0.52 13 -0.59 17 30
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.009 0.25 0.49 4 -0.79 16 20
SP1 0.029 0.076 0.12 71 -0.14 70 141
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 0.007 0.045 -10000 0 -0.078 1 1
STAT6 (dimer)/ETS1 -0.056 0.37 0.59 1 -0.94 30 31
SOCS1 -0.041 0.3 0.5 6 -0.67 32 38
SOCS3 -0.006 0.22 -10000 0 -0.69 2 2
FCER2 -0.03 0.32 0.65 1 -0.81 13 14
PARP14 0.001 0.001 -10000 0 -10000 0 0
CCL17 -0.065 0.38 0.72 1 -1 22 23
GRB2 0.035 0.007 -10000 0 0 17 17
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP 0.002 0.22 0.44 11 -0.58 19 30
T cell proliferation -0.073 0.38 0.64 3 -1 30 33
IL4R/JAK1 -0.073 0.38 0.66 1 -1 28 29
EGR2 -0.12 0.5 0.72 1 -1.3 51 52
JAK2 0.019 0.066 0.15 18 -10000 0 18
JAK3 0.035 0.016 -10000 0 -0.032 19 19
PIK3R1 0.032 0.012 -10000 0 0 63 63
JAK1 0.026 0.039 0.1 10 -10000 0 10
COL1A2 -0.11 0.48 0.53 2 -1.2 76 78
CCL26 -0.064 0.38 0.68 2 -0.96 32 34
IL4R -0.061 0.41 0.8 3 -1.1 25 28
PTPN6 0.015 0.037 -10000 0 -0.056 12 12
IL13RA2 -0.32 0.66 0.76 3 -1.1 173 176
IL13RA1 0.023 0.067 0.15 18 -10000 0 18
IRF4 0.046 0.11 -10000 0 -10000 0 0
ARG1 -0.003 0.22 0.5 4 -0.89 10 14
CBL -0.01 0.24 0.48 6 -0.56 17 23
GTF3A 0.048 0.034 0.12 70 -0.15 3 73
PIK3CA 0.031 0.013 -10000 0 0 80 80
IL13RA1/JAK2 0.025 0.1 0.23 13 -0.16 20 33
IRF4/BCL6 0.042 0.11 -10000 0 -10000 0 0
CD40LG 0.041 0.004 0.14 1 -10000 0 1
MAPK14 -0.007 0.24 0.48 6 -0.58 13 19
mitosis -0.021 0.26 0.5 6 -0.66 33 39
STAT6 -0.07 0.43 0.78 6 -1.1 31 37
SPI1 0.037 0.013 0.1 2 -10000 0 2
RPS6KB1 -0.025 0.26 0.47 7 -0.65 32 39
STAT6 (dimer) -0.07 0.43 0.79 5 -1.1 31 36
STAT6 (dimer)/PARP14 -0.084 0.38 -10000 0 -1 31 31
mast cell activation -0.002 0.016 -10000 0 -0.041 20 20
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 0.005 0.22 0.48 4 -0.59 6 10
FRAP1 -0.026 0.27 0.51 5 -0.7 33 38
LTA -0.068 0.38 0.72 1 -1.1 21 22
FES 0.035 0.007 -10000 0 0 17 17
T-helper 1 cell differentiation 0.067 0.42 1.1 31 -0.78 6 37
CCL11 -0.069 0.36 -10000 0 -1 23 23
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES 0.009 0.22 0.5 5 -0.61 5 10
IL2RG 0.034 0.016 -10000 0 -0.032 13 13
IL10 -0.052 0.39 0.71 3 -1 22 25
IRS1 0.033 0.011 -10000 0 0 52 52
IRS2 0.03 0.014 -10000 0 0 96 96
IL4 0.022 0.18 0.52 2 -0.88 7 9
IL5 -0.067 0.38 0.72 1 -1 23 24
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.06 0.39 0.66 12 -0.9 39 51
COL1A1 0.017 0.26 0.56 14 -1 8 22
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.077 0.38 -10000 0 -1.1 26 26
IL2R gamma/JAK3 0.054 0.019 -10000 0 -10000 0 0
TFF3 -0.062 0.38 0.72 1 -1 24 25
ALOX15 -0.067 0.38 0.72 1 -1.1 21 22
MYBL1 0.03 0.014 -10000 0 0 97 97
T-helper 2 cell differentiation -0.048 0.34 0.63 4 -0.81 33 37
SHC1 0.033 0.011 -10000 0 0 52 52
CEBPB 0.035 0.015 0.1 2 -10000 0 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.019 0.26 0.52 5 -0.75 22 27
mol:PI-3-4-5-P3 -0.025 0.27 0.51 5 -0.7 33 38
PI3K -0.03 0.29 0.52 5 -0.75 33 38
DOK2 0 0 -10000 0 -10000 0 0
ETS1 0.004 0.047 -10000 0 -0.085 13 13
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 0.002 0.22 0.43 11 -0.57 22 33
ITGB3 -0.067 0.38 0.72 1 -1 22 23
PIGR -0.055 0.38 0.71 2 -1.1 21 23
IGHE -0.007 0.079 0.18 37 -0.18 18 55
MAPKKK cascade 0.003 0.21 0.43 12 -0.56 22 34
BCL6 0.031 0.012 -10000 0 0 69 69
OPRM1 -0.067 0.38 0.72 1 -1 22 23
RETNLB -0.064 0.38 0.68 2 -0.96 32 34
SELP -0.063 0.38 0.79 2 -1 22 24
AICDA -0.066 0.36 -10000 0 -1 20 20
E-cadherin signaling in the nascent adherens junction

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.007 0.071 -10000 0 -0.29 22 22
KLHL20 0.048 0.09 0.2 61 -0.18 20 81
CYFIP2 0.031 0.013 -10000 0 0 78 78
Rac1/GDP 0.007 0.061 0.19 2 -0.26 14 16
ENAH 0.007 0.074 -10000 0 -0.31 21 21
AP1M1 0 0 -10000 0 -10000 0 0
RAP1B 0 0 0 60 0 12 72
RAP1A 0.036 0.005 -10000 0 0 11 11
CTNNB1 0.036 0.006 -10000 0 0 15 15
CDC42/GTP -0.026 0.052 0.12 13 -0.19 24 37
ABI1/Sra1/Nap1 -0.014 0.033 -10000 0 -0.13 31 31
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.084 0.036 -10000 0 -0.13 8 8
RAPGEF1 -0.006 0.074 0.18 1 -0.28 21 22
CTNND1 0.034 0.009 -10000 0 0 32 32
regulation of calcium-dependent cell-cell adhesion 0.02 0.076 -10000 0 -0.29 23 23
CRK 0 0.076 0.2 1 -0.29 22 23
E-cadherin/gamma catenin/alpha catenin 0.061 0.035 -10000 0 -0.12 8 8
alphaE/beta7 Integrin 0.049 0.025 -10000 0 -0.14 7 7
IQGAP1 0.033 0.011 -10000 0 0 51 51
NCKAP1 0.036 0.002 -10000 0 0 2 2
Rap1/GTP/I-afadin 0.043 0.015 -10000 0 -0.1 1 1
DLG1 0.007 0.075 -10000 0 -0.3 23 23
ChemicalAbstracts:7440-70-2 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.035 0.044 -10000 0 -0.18 30 30
MLLT4 0.034 0.009 -10000 0 0 36 36
ARF6/GTP/NME1/Tiam1 0.036 0.033 -10000 0 -0.1 23 23
PI3K -0.043 0.058 0.059 2 -0.23 30 32
ARF6 0.035 0.008 -10000 0 0 27 27
mol:Ca2+ 0 0 0.001 69 0 27 96
E-cadherin/gamma catenin 0.048 0.018 -10000 0 -10000 0 0
TIAM1 0.033 0.011 -10000 0 0 46 46
E-cadherin(dimer)/Ca2+ 0.07 0.054 -10000 0 -0.14 25 25
AKT1 -0.023 0.052 0.13 7 -0.18 25 32
PIK3R1 0.032 0.012 -10000 0 0 63 63
CDH1 0.034 0.01 -10000 0 0 38 38
RhoA/GDP 0.011 0.07 0.19 3 -0.24 18 21
actin cytoskeleton organization 0.04 0.072 0.17 62 -0.14 17 79
CDC42/GDP 0.011 0.068 0.19 3 -0.24 15 18
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.049 -10000 0 -0.2 23 23
ITGB7 0.036 0.005 -10000 0 0 11 11
RAC1 0.024 0.017 -10000 0 0 173 173
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.057 -10000 0 -0.15 25 25
E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.031 -10000 0 -0.11 10 10
mol:GDP -0.006 0.071 0.18 3 -0.27 16 19
CDC42/GTP/IQGAP1 0.035 0.042 -10000 0 -0.12 33 33
JUP 0.033 0.011 -10000 0 0 51 51
p120 catenin/RhoA/GDP 0.026 0.077 0.2 3 -0.24 19 22
RAC1/GTP/IQGAP1 0.023 0.042 -10000 0 -0.12 30 30
PIP5K1C/AP1M1 0.02 0.03 -10000 0 -0.13 18 18
RHOA 0.035 0.007 -10000 0 0 18 18
CDC42 0.035 0.008 -10000 0 0 24 24
CTNNA1 0.035 0.007 -10000 0 0 20 20
positive regulation of S phase of mitotic cell cycle 0.014 0.045 0.11 8 -0.12 28 36
NME1 0 0 -10000 0 0 31 31
clathrin coat assembly 0 0 -10000 0 -10000 0 0
TJP1 0.008 0.072 -10000 0 -0.3 20 20
regulation of cell-cell adhesion -0.028 0.04 -10000 0 -0.17 26 26
WASF2 -0.008 0.018 -10000 0 -0.071 31 31
Rap1/GTP -0.023 0.061 0.15 19 -0.22 22 41
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.09 0.051 -10000 0 -0.13 13 13
CCND1 0.016 0.054 0.13 8 -0.15 28 36
VAV2 0.019 0.1 -10000 0 -0.52 9 9
RAP1/GDP -0.011 0.064 0.16 17 -0.24 16 33
adherens junction assembly 0.009 0.071 -10000 0 -0.29 20 20
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
ABI1 0.026 0.017 -10000 0 0 152 152
PIP5K1C 0.033 0.011 -10000 0 0 50 50
regulation of heterotypic cell-cell adhesion 0.068 0.047 0.2 3 -0.13 14 17
E-cadherin/beta catenin 0.006 0.02 -10000 0 -0.092 7 7
mol:GTP 0 0 0.001 63 0 31 94
SRC 0.006 0.073 -10000 0 -0.29 23 23
PIK3CA 0.031 0.013 -10000 0 0 80 80
Rac1/GTP -0.007 0.07 0.18 1 -0.28 21 22
E-cadherin/beta catenin/alpha catenin 0.064 0.036 -10000 0 -0.13 10 10
ITGAE 0.035 0.007 -10000 0 0 19 19
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.077 -10000 0 -0.3 23 23
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 0.016 0.11 0.26 13 -0.38 21 34
CRKL 0.019 0.1 0.22 13 -0.39 22 35
HRAS 0.034 0.1 0.25 9 -0.32 22 31
mol:PIP3 0.052 0.12 0.29 29 -0.35 20 49
SPRED1 0 0 -10000 0 -10000 0 0
SPRED2 0.036 0.004 -10000 0 0 6 6
GAB1 0.025 0.11 0.24 11 -0.4 22 33
FOXO3 0.053 0.16 0.31 30 -0.36 38 68
AKT1 0.054 0.17 0.33 28 -0.39 38 66
BAD 0.047 0.16 0.31 29 -0.37 39 68
megakaryocyte differentiation 0.025 0.1 0.24 11 -0.38 20 31
GSK3B 0.047 0.17 0.32 32 -0.39 39 71
RAF1 0.023 0.091 0.23 14 -0.28 22 36
SHC1 0.033 0.011 -10000 0 0 52 52
STAT3 0.018 0.1 0.22 5 -0.4 22 27
STAT1 0.015 0.2 -10000 0 -0.87 21 21
HRAS/SPRED1 0.025 0.09 0.22 10 -0.27 23 33
cell proliferation 0.01 0.095 0.23 4 -0.38 22 26
PIK3CA 0.031 0.013 -10000 0 0 80 80
TEC 0.036 0.005 -10000 0 0 8 8
RPS6KB1 0.055 0.12 0.27 19 -0.37 21 40
HRAS/SPRED2 0.044 0.1 0.25 12 -0.28 21 33
LYN/TEC/p62DOK 0.065 0.12 -10000 0 -0.4 22 22
MAPK3 0.02 0.088 0.24 25 -0.22 18 43
STAP1 0.026 0.1 0.22 6 -0.39 22 28
GRAP2 0.034 0.009 -10000 0 0 35 35
JAK2 0.015 0.17 -10000 0 -0.74 21 21
STAT1 (dimer) 0.02 0.2 -10000 0 -0.85 21 21
mol:Gleevec -0.002 0.006 -10000 0 -0.023 1 1
GRB2/SOCS1/VAV1 0.072 0.11 0.28 1 -0.38 22 23
actin filament polymerization 0.027 0.1 0.23 5 -0.38 22 27
LYN 0.031 0.013 -10000 0 0 74 74
STAP1/STAT5A (dimer) 0.024 0.14 0.28 2 -0.54 21 23
PIK3R1 0.032 0.012 -10000 0 0 63 63
CBL/CRKL/GRB2 0.053 0.11 0.27 5 -0.38 21 26
PI3K 0.061 0.13 0.3 16 -0.38 20 36
PTEN 0.026 0.017 -10000 0 0 148 148
SCF/KIT/EPO/EPOR 0.022 0.22 -10000 0 -1 21 21
MAPK8 0.009 0.095 0.23 3 -0.39 22 25
STAT3 (dimer) 0.02 0.1 0.24 7 -0.39 22 29
positive regulation of transcription 0.021 0.078 0.22 27 -0.18 18 45
mol:GDP 0.041 0.098 0.23 2 -0.34 21 23
PIK3C2B 0.025 0.1 0.24 11 -0.39 22 33
CBL/CRKL 0.041 0.11 0.26 6 -0.38 21 27
FER 0.023 0.1 0.24 6 -0.39 22 28
SH2B3 0.026 0.1 0.22 6 -0.39 22 28
PDPK1 0.046 0.12 0.28 29 -0.32 22 51
SNAI2 0.026 0.11 0.23 11 -0.4 21 32
positive regulation of cell proliferation 0.027 0.17 0.32 1 -0.66 21 22
KITLG 0.038 0.021 -10000 0 -0.051 20 20
cell motility 0.027 0.17 0.32 1 -0.66 21 22
PTPN6 0.023 0.025 -10000 0 -0.033 67 67
EPOR 0.048 0.083 -10000 0 -0.49 1 1
STAT5A (dimer) 0.032 0.14 0.3 2 -0.54 21 23
SOCS1 0.036 0.005 -10000 0 0 8 8
cell migration -0.022 0.1 0.38 22 -0.25 7 29
SOS1 0 0 -10000 0 -10000 0 0
EPO 0.025 0.022 -10000 0 -0.036 15 15
VAV1 0.034 0.009 -10000 0 0 35 35
GRB10 0.011 0.087 0.3 4 -0.36 17 21
PTPN11 0.027 0.022 -10000 0 -0.032 56 56
SCF/KIT 0.03 0.11 0.24 6 -0.41 22 28
GO:0007205 -0.002 0.007 0.021 20 -0.022 2 22
MAP2K1 0.013 0.081 0.22 13 -0.23 22 35
CBL 0.036 0.004 -10000 0 0 7 7
KIT 0.006 0.24 -10000 0 -1.1 21 21
MAP2K2 0.018 0.093 0.28 25 -0.23 21 46
SHC/Grb2/SOS1 0.052 0.11 -10000 0 -0.36 21 21
STAT5A 0.032 0.14 0.3 2 -0.56 21 23
GRB2 0.035 0.007 -10000 0 0 17 17
response to radiation 0.027 0.11 0.23 12 -0.39 21 33
SHC/GRAP2 0.043 0.03 -10000 0 -0.14 8 8
PTPRO 0.024 0.1 0.24 11 -0.39 20 31
SH2B2 0.026 0.1 0.22 6 -0.39 22 28
DOK1 0.036 0.002 -10000 0 0 2 2
MATK 0.019 0.1 0.23 4 -0.39 22 26
CREBBP 0.051 0.045 0.13 6 -0.12 21 27
BCL2 0.04 0.13 -10000 0 -0.87 6 6
Aurora A signaling

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.023 0.057 0.16 1 -0.19 27 28
BIRC5 0.029 0.015 -10000 0 0 108 108
NFKBIA -0.008 0.042 0.21 3 -0.18 16 19
CPEB1 0.033 0.012 -10000 0 0 57 57
AKT1 -0.006 0.033 0.24 1 -0.18 7 8
NDEL1 0.035 0.007 -10000 0 0 18 18
Aurora A/BRCA1 0.023 0.043 0.14 1 -0.15 23 24
NDEL1/TACC3 0.036 0.057 0.16 1 -0.14 37 38
GADD45A 0.031 0.013 -10000 0 0 75 75
GSK3B 0.035 0.016 0.089 25 0 40 65
PAK1/Aurora A 0.029 0.05 0.16 1 -0.16 25 26
MDM2 0.033 0.011 -10000 0 0 46 46
JUB 0 0 -10000 0 -10000 0 0
TPX2 -0.012 0.026 0.092 26 -10000 0 26
TP53 0.004 0.07 -10000 0 -0.23 33 33
DLG7 -0.004 0.043 0.12 10 -0.18 13 23
AURKAIP1 0 0 -10000 0 -10000 0 0
ARHGEF7 0.032 0.012 -10000 0 0 59 59
G2 phase of mitotic cell cycle 0 0 -10000 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.038 0.061 0.17 1 -0.15 37 38
G2/M transition of mitotic cell cycle 0.023 0.042 -10000 0 -0.15 23 23
AURKA 0.006 0.05 0.13 24 -0.21 19 43
AURKB 0.008 0.034 -10000 0 -0.14 26 26
CDC25B 0 0.074 -10000 0 -0.28 28 28
G2/M transition checkpoint 0.001 0.036 0.088 1 -0.14 24 25
mRNA polyadenylation 0.015 0.051 -10000 0 -0.13 46 46
Aurora A/CPEB 0.015 0.051 0.14 1 -0.13 46 47
Aurora A/TACC1/TRAP/chTOG 0.051 0.081 -10000 0 -0.16 50 50
BRCA1 0.036 0.006 -10000 0 0 12 12
centrosome duplication 0.029 0.049 0.16 1 -0.16 25 26
regulation of centrosome cycle 0.035 0.056 0.15 1 -0.14 37 38
spindle assembly 0.049 0.08 -10000 0 -0.16 50 50
TDRD7 0.034 0.01 -10000 0 0 40 40
Aurora A/RasGAP/Survivin 0.04 0.073 -10000 0 -0.14 59 59
CENPA 0.002 0.064 -10000 0 -0.26 25 25
Aurora A/PP2A 0.029 0.05 0.16 1 -0.16 25 26
meiosis 0 0 -10000 0 -10000 0 0
protein catabolic process -0.007 0.052 -10000 0 -0.2 21 21
negative regulation of DNA binding 0.002 0.073 -10000 0 -0.24 36 36
prophase 0 0 -10000 0 -10000 0 0
GIT1/beta-PIX 0.04 0.045 -10000 0 -0.14 27 27
RASA1 0.034 0.009 -10000 0 0 32 32
Ajuba/Aurora A 0.001 0.036 0.089 1 -0.14 24 25
mitotic prometaphase -0.004 0.009 0.068 8 -10000 0 8
proteasomal ubiquitin-dependent protein catabolic process 0.006 0.049 0.13 24 -0.21 19 43
TACC1 0.035 0.008 -10000 0 0 23 23
TACC3 0.032 0.012 -10000 0 0 59 59
Aurora A/Antizyme1 0.023 0.044 0.14 1 -0.15 24 25
Aurora A/RasGAP 0.027 0.06 0.16 1 -0.22 23 24
OAZ1 0.034 0.009 -10000 0 0 34 34
RAN 0.036 0.005 -10000 0 0 10 10
mitosis 0 0 -10000 0 -10000 0 0
PRKACA 0.036 0.015 0.088 27 0 25 52
GIT1 0.036 0.003 -10000 0 0 4 4
GIT1/beta-PIX/PAK1 0.058 0.047 -10000 0 -0.12 26 26
Importin alpha/Importin beta/TPX2 -0.012 0.026 0.092 26 -10000 0 26
PPP2R5D 0.036 0.004 -10000 0 0 5 5
Aurora A/TPX2 -0.028 0.055 0.096 4 -0.22 21 25
PAK1 0.036 0.006 -10000 0 0 15 15
CKAP5 0.034 0.01 -10000 0 0 37 37
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.036 0.005 -10000 0 0 11 11
Caspase 8 (4 units) -0.009 0.096 -10000 0 -0.24 23 23
NEF 0.002 0 -10000 0 -10000 0 0
NFKBIA 0.038 0.019 0.077 64 -10000 0 64
BIRC3 -0.025 0.029 0.18 2 -0.2 2 4
CYCS -0.003 0.083 0.18 51 -0.26 10 61
RIPK1 0.035 0.007 -10000 0 0 20 20
CD247 0.002 0 -10000 0 -10000 0 0
MAP2K7 -0.01 0.1 -10000 0 -0.41 6 6
protein ubiquitination 0.013 0.065 0.21 3 -0.27 6 9
CRADD 0.036 0.006 -10000 0 0 12 12
DAXX 0.036 0.004 -10000 0 0 6 6
FAS 0.019 0.018 -10000 0 0 238 238
BID -0.002 0.056 -10000 0 -0.27 9 9
NF-kappa-B/RelA/I kappa B alpha 0.075 0.054 -10000 0 -0.13 17 17
TRADD 0.036 0.005 -10000 0 0 11 11
MAP3K5 0.03 0.014 -10000 0 0 90 90
CFLAR 0.036 0.005 -10000 0 0 8 8
FADD 0.036 0.006 -10000 0 0 12 12
NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.075 0.055 -10000 0 -0.13 17 17
MAPK8 -0.007 0.093 -10000 0 -0.38 6 6
APAF1 0.036 0.003 -10000 0 0 4 4
TRAF1 0.035 0.008 -10000 0 0 23 23
TRAF2 0.036 0.006 -10000 0 0 15 15
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG 0.003 0.06 -10000 0 -0.28 9 9
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.031 0.075 -10000 0 -0.29 9 9
CHUK 0.013 0.066 0.21 3 -0.29 6 9
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.041 0.082 -10000 0 -0.12 58 58
TCRz/NEF 0.007 0.001 -10000 0 -10000 0 0
TNF 0.036 0.003 -10000 0 0 4 4
FASLG 0.018 0.003 -10000 0 -10000 0 0
NFKB1 0.042 0.016 0.078 72 -10000 0 72
TNFR1A/BAG4/TNF-alpha 0.053 0.056 -10000 0 -0.12 41 41
CASP6 0.006 0.11 -10000 0 -0.57 7 7
CASP7 -0.032 0.14 0.27 11 -0.32 25 36
RELA 0.043 0.016 0.078 74 -10000 0 74
CASP2 0.024 0.017 -10000 0 0 169 169
CASP3 0 0.11 0.26 9 -0.36 12 21
TNFRSF1A 0.032 0.012 -10000 0 0 64 64
TNFR1A/BAG4 0.035 0.054 -10000 0 -0.14 42 42
CASP8 0.036 0.006 -10000 0 0 13 13
CASP9 0.034 0.009 -10000 0 0 33 33
MAP3K14 0.026 0.076 0.19 1 -0.3 7 8
APAF-1/Caspase 9 -0.009 0.085 0.17 9 -0.26 9 18
BCL2 -0.015 0.09 0.27 1 -0.35 5 6
p75(NTR)-mediated signaling

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.05 0.023 -10000 0 -0.14 6 6
Necdin/E2F1 -0.018 0.085 -10000 0 -0.14 156 156
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.073 0.047 -10000 0 -0.12 23 23
NGF (dimer)/p75(NTR)/BEX1 0.011 0.063 -10000 0 -0.12 95 95
NT-4/5 (dimer)/p75(NTR) 0.023 0.009 -10000 0 -10000 0 0
IKBKB 0.036 0.003 -10000 0 0 4 4
AKT1 -0.016 0.078 0.2 25 -0.2 23 48
IKBKG 0.037 0 -10000 0 -10000 0 0
BDNF 0.032 0.012 -10000 0 0 67 67
MGDIs/NGR/p75(NTR)/LINGO1 0.021 0.009 -10000 0 -10000 0 0
FURIN 0.036 0.006 -10000 0 0 12 12
proBDNF (dimer)/p75(NTR)/Sortilin 0.055 0.034 -10000 0 -0.12 2 2
LINGO1 0 0 -10000 0 -10000 0 0
Sortilin/TRAF6/NRIF 0.023 0.067 -10000 0 -0.16 46 46
proBDNF (dimer) 0.032 0.012 -10000 0 0 67 67
NTRK1 0.035 0.006 -10000 0 0 16 16
RTN4R 0 0 -10000 0 -10000 0 0
neuron apoptosis 0.004 0.11 0.26 2 -0.36 29 31
IRAK1 0.035 0.007 -10000 0 0 19 19
SHC1 -0.003 0.035 0.091 61 -10000 0 61
ARHGDIA 0.035 0.007 -10000 0 0 18 18
RhoA/GTP 0.024 0.019 -10000 0 -0.13 7 7
Gamma Secretase 0.08 0.069 -10000 0 -0.15 28 28
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.039 0.058 -10000 0 -0.11 54 54
MAGEH1 0.032 0.013 -10000 0 0 70 70
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.003 0.075 -10000 0 -0.11 146 146
Mammalian IAPs/DIABLO 0.057 0.035 -10000 0 -0.15 6 6
proNGF (dimer) 0 0 -10000 0 -10000 0 0
MAGED1 0.035 0.008 -10000 0 0 26 26
APP 0.035 0.007 -10000 0 0 21 21
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
ZNF274 0.034 0.009 -10000 0 0 36 36
RhoA/GDP/RHOGDI 0.05 0.029 0.18 1 -0.1 6 7
NGF 0 0 -10000 0 -10000 0 0
cell cycle arrest 0.004 0.054 0.22 8 -10000 0 8
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.016 0.056 -10000 0 -0.18 32 32
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.041 0.019 -10000 0 -0.12 1 1
NCSTN 0.035 0.008 -10000 0 0 28 28
mol:GTP 0.031 0.04 -10000 0 -0.11 29 29
PSENEN 0.035 0.008 -10000 0 0 28 28
mol:ceramide -0.007 0.044 0.19 8 -10000 0 8
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.014 0.052 -10000 0 -0.27 9 9
p75(NTR)/beta APP 0.042 0.032 -10000 0 -0.14 9 9
BEX1 0.028 0.015 -10000 0 0 115 115
mol:GDP -0.008 0.003 -10000 0 -10000 0 0
NGF (dimer) 0.046 0.034 -10000 0 -10000 0 0
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.039 0.017 -10000 0 -10000 0 0
PIK3R1 0.032 0.012 -10000 0 0 63 63
RAC1/GTP 0.024 0.024 -10000 0 -0.095 5 5
MYD88 0.034 0.009 -10000 0 0 36 36
CHUK 0.025 0.017 -10000 0 0 163 163
NGF (dimer)/p75(NTR)/PKA 0.031 0.041 -10000 0 -0.12 29 29
RHOB 0.031 0.013 -10000 0 0 74 74
RHOA 0.035 0.007 -10000 0 0 18 18
MAGE-G1/E2F1 0.026 0.005 -10000 0 -10000 0 0
NT3 (dimer) 0.035 0.008 -10000 0 0 23 23
TP53 -0.014 0.064 0.17 24 -0.2 6 30
PRDM4 -0.006 0.046 0.19 8 -10000 0 8
BDNF (dimer) 0.08 0.032 -10000 0 -10000 0 0
PIK3CA 0.031 0.013 -10000 0 0 80 80
SORT1 0.036 0.006 -10000 0 0 15 15
activation of caspase activity 0.066 0.045 -10000 0 -0.12 23 23
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.057 0.031 -10000 0 -0.11 5 5
RHOC 0.035 0.007 -10000 0 0 20 20
XIAP 0 0 -10000 0 -10000 0 0
MAPK10 0.016 0.1 0.2 32 -0.31 16 48
DIABLO 0.036 0.004 -10000 0 0 6 6
SMPD2 -0.007 0.044 0.19 8 -10000 0 8
APH1B 0.035 0.006 -10000 0 0 16 16
APH1A 0.036 0.005 -10000 0 0 11 11
proNGF (dimer)/p75(NTR)/Sortilin 0.041 0.023 -10000 0 -0.12 4 4
PSEN1 0.033 0.011 -10000 0 0 46 46
APAF-1/Pro-Caspase 9 0.05 0.018 -10000 0 -0.14 2 2
NT3 (dimer)/p75(NTR) 0.044 0.021 -10000 0 -10000 0 0
MAPK8 0.004 0.077 0.2 18 -0.26 9 27
MAPK9 0.028 0.088 0.2 37 -0.26 9 46
APAF1 0.036 0.003 -10000 0 0 4 4
NTF3 0.035 0.008 -10000 0 0 23 23
NTF4 0 0 -10000 0 -10000 0 0
NDN 0.018 0.018 -10000 0 0 258 258
RAC1/GDP 0.017 0.019 -10000 0 -0.13 5 5
RhoA-B-C/GDP 0.049 0.073 -10000 0 -0.14 53 53
p75 CTF/Sortilin/TRAF6/NRIF 0.076 0.055 -10000 0 -0.12 32 32
RhoA-B-C/GTP 0.031 0.04 -10000 0 -0.11 29 29
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.087 0.058 -10000 0 -0.12 25 25
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.085 0.029 -10000 0 -0.12 2 2
PRKACB 0.033 0.011 -10000 0 0 50 50
proBDNF (dimer)/p75 ECD 0.046 0.019 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 0.031 0.013 -10000 0 0 81 81
BIRC2 0.036 0.005 -10000 0 0 11 11
neuron projection morphogenesis -0.016 0.07 0.14 27 -0.16 29 56
BAD 0.012 0.091 0.19 26 -0.28 15 41
RIPK2 0.036 0.006 -10000 0 0 14 14
NGFR 0.031 0.013 -10000 0 0 71 71
CYCS -0.012 0.042 0.19 5 -0.19 3 8
ADAM17 0.036 0.006 -10000 0 0 13 13
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.057 0.03 -10000 0 -0.11 3 3
BCL2L11 0.012 0.091 0.19 25 -0.28 14 39
BDNF (dimer)/p75(NTR) 0.041 0.023 -10000 0 -10000 0 0
PI3K 0.028 0.068 -10000 0 -0.12 71 71
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.039 0.021 -10000 0 -0.1 4 4
NDNL2 0 0 -10000 0 -10000 0 0
YWHAE 0.035 0.008 -10000 0 0 27 27
PRKCI 0.035 0.008 -10000 0 0 26 26
NGF (dimer)/p75(NTR) 0.023 0.009 -10000 0 -10000 0 0
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.05 0.047 -10000 0 -0.12 27 27
TRAF6 0.036 0.005 -10000 0 0 10 10
RAC1 0.024 0.017 -10000 0 0 173 173
PRKCZ 0 0 -10000 0 -10000 0 0
PLG 0.034 0.01 -10000 0 0 37 37
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 0.031 0.035 0.14 16 -0.15 2 18
SQSTM1 0.034 0.009 -10000 0 0 35 35
NGFRAP1 0.036 0.006 -10000 0 0 13 13
CASP3 0.012 0.09 0.19 24 -0.27 16 40
E2F1 0.03