Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	428.0	51.0	-0.652	0.039	1000.0	-1000.0	-0.104	-1000.0
HIF-1-alpha transcription factor network	6.0	475.0	76.0	-0.529	0.054	1000.0	-1000.0	-0.071	-1000.0
TCGA08_retinoblastoma	5.0	43.0	8.0	-0.11	0.054	1000.0	-1000.0	-0.002	-1000.0
Osteopontin-mediated events	4.0	178.0	38.0	-0.309	0.04	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by the Hedgehog family	4.0	232.0	52.0	-0.27	0.119	1000.0	-1000.0	-0.032	-1000.0
Endothelins	4.0	401.0	96.0	-0.271	0.051	1000.0	-1000.0	-0.042	-1000.0
IL23-mediated signaling events	4.0	282.0	60.0	-0.58	0.037	1000.0	-1000.0	-0.083	-1000.0
IL12-mediated signaling events	3.0	279.0	87.0	-0.285	0.04	1000.0	-1000.0	-0.061	-1000.0
IL4-mediated signaling events	3.0	319.0	91.0	-0.724	0.566	1000.0	-1000.0	-0.117	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	315.0	97.0	-0.158	0.04	1000.0	-1000.0	-0.065	-1000.0
TCGA08_p53	3.0	24.0	7.0	-0.09	0.055	1000.0	-1000.0	-0.011	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	144.0	44.0	-0.141	0.04	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	375.0	125.0	-0.122	0.055	1000.0	-1000.0	-0.053	-1000.0
IL27-mediated signaling events	3.0	175.0	51.0	-0.218	0.167	1000.0	-1000.0	-0.062	-1000.0
Wnt signaling	3.0	23.0	7.0	-0.098	0.039	1000.0	-1000.0	-0.015	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	255.0	68.0	-0.471	0.163	1000.0	-1000.0	-0.082	-1000.0
EGFR-dependent Endothelin signaling events	3.0	73.0	21.0	-0.109	0.054	1000.0	-1000.0	-0.015	-1000.0
Syndecan-1-mediated signaling events	2.0	90.0	34.0	-0.172	0.04	1000.0	-1000.0	-0.046	-1000.0
Visual signal transduction: Cones	2.0	110.0	38.0	-0.163	0.051	1000.0	-1000.0	-0.007	-1000.0
Noncanonical Wnt signaling pathway	2.0	54.0	26.0	-0.098	0.04	1000.0	-1000.0	-0.046	-1000.0
Syndecan-2-mediated signaling events	2.0	141.0	69.0	-0.193	0.057	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	2.0	190.0	81.0	-0.209	0.073	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	2.0	232.0	82.0	-0.153	0.05	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	2.0	247.0	114.0	-0.404	0.085	1000.0	-1000.0	-0.057	-1000.0
IL1-mediated signaling events	2.0	149.0	62.0	-0.147	0.067	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	2.0	133.0	48.0	-0.123	0.04	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	2.0	90.0	35.0	-0.193	0.061	1000.0	-1000.0	-0.04	-1000.0
Integrins in angiogenesis	2.0	191.0	84.0	-0.163	0.046	1000.0	-1000.0	-0.044	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	207.0	93.0	-0.057	0.054	1000.0	-1000.0	-0.05	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.025	-0.0	1000.0	-1000.0	-0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	77.0	31.0	-0.245	0.043	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	2.0	191.0	75.0	-0.452	0.046	1000.0	-1000.0	-0.049	-1000.0
BCR signaling pathway	2.0	265.0	99.0	-0.191	0.073	1000.0	-1000.0	-0.059	-1000.0
Syndecan-4-mediated signaling events	2.0	187.0	67.0	-0.117	0.056	1000.0	-1000.0	-0.037	-1000.0
Insulin Pathway	2.0	148.0	74.0	-0.127	0.065	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	2.0	253.0	86.0	-0.196	0.186	1000.0	-1000.0	-0.063	-1000.0
Visual signal transduction: Rods	2.0	155.0	52.0	-0.218	0.048	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	191.0	78.0	-0.124	0.045	1000.0	-1000.0	-0.051	-1000.0
Caspase cascade in apoptosis	1.0	124.0	74.0	-0.064	0.052	1000.0	-1000.0	-0.052	-1000.0
Coregulation of Androgen receptor activity	1.0	91.0	76.0	-0.209	0.051	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	1.0	75.0	69.0	-0.316	0.074	1000.0	-1000.0	-0.049	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	-0.013	0.039	1000.0	-1000.0	-0.006	-1000.0
Thromboxane A2 receptor signaling	1.0	199.0	105.0	-0.089	0.052	1000.0	-1000.0	-0.054	-1000.0
Cellular roles of Anthrax toxin	1.0	55.0	39.0	-0.062	0.036	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	1.0	114.0	62.0	-0.109	0.04	1000.0	-1000.0	-0.018	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	143.0	85.0	-0.129	0.043	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PTP1B	1.0	145.0	76.0	-0.146	0.1	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	67.0	65.0	-0.245	0.078	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	73.0	61.0	-0.167	0.061	1000.0	-1000.0	-0.039	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	78.0	46.0	-0.257	0.045	1000.0	-1000.0	-0.072	-1000.0
Glypican 1 network	1.0	53.0	48.0	-0.011	0.054	1000.0	-1000.0	-0.028	-1000.0
PLK1 signaling events	1.0	86.0	85.0	-0.138	0.059	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	1.0	104.0	53.0	-0.093	0.039	1000.0	-1000.0	-0.041	-1000.0
IFN-gamma pathway	1.0	104.0	68.0	-0.111	0.04	1000.0	-1000.0	-0.061	-1000.0
Nectin adhesion pathway	1.0	124.0	63.0	-0.099	0.06	1000.0	-1000.0	-0.056	-1000.0
Ceramide signaling pathway	1.0	92.0	76.0	-0.064	0.055	1000.0	-1000.0	-0.048	-1000.0
TRAIL signaling pathway	1.0	83.0	48.0	-0.029	0.04	1000.0	-1000.0	-0.045	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	70.0	52.0	-0.092	0.083	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	1.0	61.0	43.0	-0.169	0.078	1000.0	-1000.0	-0.037	-1000.0
S1P1 pathway	1.0	57.0	36.0	-0.132	0.039	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	1.0	87.0	47.0	-0.112	0.049	1000.0	-1000.0	-0.038	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.041	0.039	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	56.0	45.0	-0.06	0.054	1000.0	-1000.0	-0.056	-1000.0
Canonical Wnt signaling pathway	1.0	79.0	51.0	-0.167	0.095	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	1.0	115.0	85.0	-0.071	0.084	1000.0	-1000.0	-0.071	-1000.0
Effects of Botulinum toxin	1.0	33.0	26.0	-0.033	0.035	1000.0	-1000.0	-0.003	-1000.0
Nongenotropic Androgen signaling	1.0	53.0	52.0	-0.029	0.049	1000.0	-1000.0	-0.035	-1000.0
TCGA08_rtk_signaling	1.0	30.0	26.0	-0.085	0.04	1000.0	-1000.0	-0.004	-1000.0
LPA receptor mediated events	1.0	166.0	102.0	-0.223	0.068	1000.0	-1000.0	-0.074	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	123.0	74.0	-0.128	0.058	1000.0	-1000.0	-0.069	-1000.0
IGF1 pathway	1.0	67.0	57.0	-0.052	0.063	1000.0	-1000.0	-0.039	-1000.0
VEGFR1 specific signals	1.0	60.0	56.0	-0.023	0.039	1000.0	-1000.0	-0.048	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	33.0	33.0	-0.134	0.097	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	1.0	44.0	43.0	-0.085	0.04	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.029	0.029	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	-0.007	0.035	1000.0	-1000.0	0.014	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.0	0.042	1000.0	-1000.0	-0.021	-1000.0
Aurora B signaling	1.0	127.0	67.0	-0.128	0.044	1000.0	-1000.0	-0.041	-1000.0
LPA4-mediated signaling events	0.0	5.0	12.0	-0.005	0.058	1000.0	-1000.0	-0.019	-1000.0
ErbB2/ErbB3 signaling events	0.0	28.0	65.0	-0.024	0.072	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	94.0	136.0	-0.165	0.161	1000.0	-1000.0	-0.045	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	-0.003	0.068	1000.0	-1000.0	-0.029	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	8.0	34.0	-0.043	0.085	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	0.0	11.0	39.0	-0.0	0.081	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class II	0.0	43.0	75.0	-0.119	0.076	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	0.0	14.0	57.0	-0.071	0.074	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	25.0	28.0	-0.034	0.043	1000.0	-1000.0	-0.017	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.097	0.078	1000.0	-1000.0	-0.04	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	26.0	54.0	-0.04	0.052	1000.0	-1000.0	-0.065	-1000.0
Ephrin A  reverse signaling	0.0	6.0	7.0	-0.0	0.029	1000.0	-1000.0	-0.006	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	3.0	17.0	-0.003	0.084	1000.0	-1000.0	-0.034	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.037	0.057	1000.0	-1000.0	0.012	-1000.0
Aurora A signaling	0.0	46.0	60.0	-0.065	0.081	1000.0	-1000.0	-0.021	-1000.0
p75(NTR)-mediated signaling	0.0	115.0	125.0	-0.177	0.086	1000.0	-1000.0	-0.058	-1000.0
Arf6 downstream pathway	0.0	26.0	43.0	-0.041	0.054	1000.0	-1000.0	-0.032	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.026	0.042	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	0.0	18.0	55.0	0.0	0.08	1000.0	-1000.0	-0.036	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.024	0.05	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	0.0	34.0	44.0	-0.067	0.064	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.034	0.064	1000.0	-1000.0	-0.043	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	12.0	37.0	-0.004	0.09	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.091	0.071	1000.0	-1000.0	-0.022	-1000.0
Reelin signaling pathway	0.0	55.0	56.0	-0.041	0.057	1000.0	-1000.0	-0.043	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	75.0	82.0	-0.051	0.06	1000.0	-1000.0	-0.077	-1000.0
S1P5 pathway	0.0	6.0	17.0	-0.03	0.04	1000.0	-1000.0	-0.014	-1000.0
ceramide signaling pathway	0.0	28.0	49.0	-0.064	0.044	1000.0	-1000.0	-0.047	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	24.0	83.0	-0.03	0.074	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	21.0	104.0	-0.05	0.083	1000.0	-1000.0	-0.037	-1000.0
FoxO family signaling	0.0	56.0	64.0	-0.24	0.054	1000.0	-1000.0	-0.053	-1000.0
Retinoic acid receptors-mediated signaling	0.0	39.0	58.0	-0.018	0.079	1000.0	-1000.0	-0.055	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.076	0.081	1000.0	-1000.0	-0.038	-1000.0
Atypical NF-kappaB pathway	0.0	12.0	31.0	-0.0	0.057	1000.0	-1000.0	-0.027	-1000.0
IL2 signaling events mediated by PI3K	0.0	39.0	58.0	-0.031	0.091	1000.0	-1000.0	-0.043	-1000.0
Regulation of p38-alpha and p38-beta	0.0	38.0	54.0	-0.033	0.077	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	58.0	76.0	-0.049	0.06	1000.0	-1000.0	-0.075	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.065	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	-0.063	0.045	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	0.0	52.0	73.0	-0.037	0.04	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	0.0	7.0	71.0	-0.043	0.046	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	0.0	92.0	102.0	-0.119	0.075	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	0.0	25.0	42.0	-0.034	0.043	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	54.0	88.0	-0.113	0.096	1000.0	-1000.0	-0.074	-1000.0
Rapid glucocorticoid signaling	0.0	10.0	20.0	-0.0	0.04	1000.0	-1000.0	-0.007	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	90.0	120.0	-0.089	0.082	1000.0	-1000.0	-0.052	-1000.0
PDGFR-beta signaling pathway	0.0	46.0	97.0	-0.045	0.09	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	0.0	30.0	34.0	-0.109	0.057	1000.0	-1000.0	-0.038	-1000.0
S1P4 pathway	0.0	9.0	25.0	-0.0	0.048	1000.0	-1000.0	-0.028	-1000.0
p38 MAPK signaling pathway	0.0	34.0	44.0	-0.076	0.065	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.001	0.047	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	1.0	13.0	0.0	0.093	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	47.0	70.0	-0.212	0.05	1000.0	-1000.0	-0.05	-1000.0
Total	147	12063	7203	-15.8027169338	8.54597600666	131000	-131000	-5.28840377423	-131000