Correlation between gene mutation status and selected clinical features
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 325 genes and 6 clinical features across 269 patients, 41 significant findings detected with Q value < 0.25.

  • IDH1 mutation correlated to 'AGE'.

  • PUF60 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • ZNF704 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • ZNF784 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • GUF1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • FOXF1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • RBM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • C1ORF187 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • EIF4A3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • PRKRIP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • OR5W2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • C21ORF58 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CHEK1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • SLC4A11 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • JHDM1D mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • ARID3B mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • KRT13 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CDKN2C mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • DSCAM mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • MTMR7 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CXCL6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • RAG1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • LMO1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • LEFTY1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • NFKBIL2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • GJB1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • OPRM1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CCDC105 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • MAGEC2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CHP2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • OR5P2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • TGM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • JAG2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • SPAM1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • FGG mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • DPEP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • SIPA1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CCDC114 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • TLR6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • MSLNL mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CTDSP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 325 genes and 6 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 41 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE GENDER KARNOFSKY
PERFORMANCE
SCORE 		RADIATIONS
RADIATION
REGIMENINDICATION 		NEOADJUVANT
THERAPY
nMutated (%) nWild-Type logrank test t-test Fisher's exact test t-test Fisher's exact test Fisher's exact test
IDH1 15 (6%) 254 0.00425
(1.00) 		2.36e-05
(0.0451) 		1
(1.00) 		0.00152
(1.00) 		0.00321
(1.00) 		0.189
(1.00)
PUF60 4 (1%) 265 0.502
(1.00) 		0.0718
(1.00) 		0.3
(1.00) 		3.02e-05
(0.0576) 		0.114
(1.00) 		0.325
(1.00)
ZNF704 5 (2%) 264 0.511
(1.00) 		0.875
(1.00) 		0.658
(1.00) 		3.03e-05
(0.0576) 		0.34
(1.00) 		0.658
(1.00)
ZNF784 3 (1%) 266 0.344
(1.00) 		0.719
(1.00) 		0.555
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		1
(1.00)
GUF1 4 (1%) 265 0.432
(1.00) 		0.943
(1.00) 		0.618
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		1
(1.00)
FOXF1 3 (1%) 266 0.775
(1.00) 		0.879
(1.00) 		0.555
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.585
(1.00)
RBM3 3 (1%) 266 0.226
(1.00) 		0.803
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		0.265
(1.00) 		0.585
(1.00)
C1ORF187 3 (1%) 266 0.941
(1.00) 		0.956
(1.00) 		0.555
(1.00) 		3.03e-05
(0.0576) 		0.265
(1.00) 		0.0854
(1.00)
EIF4A3 3 (1%) 266 0.479
(1.00) 		0.235
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.257
(1.00)
PRKRIP1 3 (1%) 266 0.997
(1.00) 		0.567
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		0.553
(1.00) 		0.0854
(1.00)
OR5W2 6 (2%) 263 0.234
(1.00) 		0.129
(1.00) 		0.67
(1.00) 		3.02e-05
(0.0576) 		0.667
(1.00) 		1
(1.00)
C21ORF58 5 (2%) 264 0.602
(1.00) 		0.257
(1.00) 		0.352
(1.00) 		3.03e-05
(0.0576) 		0.0462
(1.00) 		0.174
(1.00)
CHEK1 5 (2%) 264 0.473
(1.00) 		0.129
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.387
(1.00)
SLC4A11 5 (2%) 264 0.348
(1.00) 		0.186
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.658
(1.00)
JHDM1D 6 (2%) 263 0.0963
(1.00) 		0.561
(1.00) 		0.191
(1.00) 		3.03e-05
(0.0576) 		0.41
(1.00) 		0.411
(1.00)
ARID3B 5 (2%) 264 0.879
(1.00) 		0.13
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		0.34
(1.00) 		0.174
(1.00)
KRT13 4 (1%) 265 0.249
(1.00) 		0.444
(1.00) 		0.618
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.132
(1.00)
CDKN2C 4 (1%) 265 0.631
(1.00) 		0.331
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		1
(1.00)
DSCAM 9 (3%) 260 0.803
(1.00) 		0.266
(1.00) 		0.498
(1.00) 		3.01e-05
(0.0575) 		1
(1.00) 		1
(1.00)
MTMR7 4 (1%) 265 0.326
(1.00) 		0.0161
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.132
(1.00)
CXCL6 3 (1%) 266 0.85
(1.00) 		0.704
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		0.265
(1.00) 		0.585
(1.00)
RAG1 5 (2%) 264 0.0866
(1.00) 		0.499
(1.00) 		0.0562
(1.00) 		3.03e-05
(0.0576) 		0.34
(1.00) 		0.658
(1.00)
LMO1 3 (1%) 266 0.588
(1.00) 		0.53
(1.00) 		0.0445
(1.00) 		3.03e-05
(0.0576) 		0.553
(1.00) 		0.257
(1.00)
LEFTY1 4 (1%) 265 0.497
(1.00) 		0.177
(1.00) 		0.131
(1.00) 		3.03e-05
(0.0576) 		0.606
(1.00) 		1
(1.00)
NFKBIL2 6 (2%) 263 0.916
(1.00) 		0.309
(1.00) 		0.67
(1.00) 		3.02e-05
(0.0576) 		0.0995
(1.00) 		0.232
(1.00)
GJB1 4 (1%) 265 0.374
(1.00) 		0.436
(1.00) 		0.131
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.632
(1.00)
OPRM1 4 (1%) 265 0.575
(1.00) 		0.65
(1.00) 		0.618
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		1
(1.00)
CCDC105 4 (1%) 265 0.341
(1.00) 		0.772
(1.00) 		0.618
(1.00) 		3.02e-05
(0.0576) 		0.303
(1.00) 		0.632
(1.00)
MAGEC2 5 (2%) 264 0.859
(1.00) 		0.399
(1.00) 		1
(1.00) 		3.02e-05
(0.0576) 		0.665
(1.00) 		1
(1.00)
CHP2 4 (1%) 265 0.168
(1.00) 		0.792
(1.00) 		0.618
(1.00) 		3.03e-05
(0.0576) 		0.303
(1.00) 		0.632
(1.00)
OR5P2 3 (1%) 266 0.0112
(1.00) 		0.143
(1.00) 		0.555
(1.00) 		3.03e-05
(0.0576) 		0.265
(1.00) 		0.585
(1.00)
TGM3 7 (3%) 262 0.589
(1.00) 		0.639
(1.00) 		0.00922
(1.00) 		3.02e-05
(0.0576) 		0.046
(1.00) 		0.703
(1.00)
JAG2 4 (1%) 265 0.38
(1.00) 		0.502
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		0.606
(1.00) 		0.632
(1.00)
SPAM1 6 (2%) 263 0.577
(1.00) 		0.358
(1.00) 		0.67
(1.00) 		3.01e-05
(0.0575) 		0.667
(1.00) 		0.0357
(1.00)
FGG 4 (1%) 265 0.113
(1.00) 		0.649
(1.00) 		0.618
(1.00) 		3.03e-05
(0.0576) 		0.606
(1.00) 		1
(1.00)
DPEP1 3 (1%) 266 0.0195
(1.00) 		0.784
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		1
(1.00)
SIPA1 3 (1%) 266 0.862
(1.00) 		0.254
(1.00) 		0.29
(1.00) 		3.03e-05
(0.0576) 		0.553
(1.00) 		0.257
(1.00)
CCDC114 6 (2%) 263 0.487
(1.00) 		0.297
(1.00) 		1
(1.00) 		3.02e-05
(0.0576) 		1
(1.00) 		1
(1.00)
TLR6 6 (2%) 263 0.918
(1.00) 		0.757
(1.00) 		0.191
(1.00) 		3.03e-05
(0.0576) 		0.41
(1.00) 		0.411
(1.00)
MSLNL 6 (2%) 263 0.677
(1.00) 		0.725
(1.00) 		0.426
(1.00) 		3.02e-05
(0.0576) 		0.667
(1.00) 		1
(1.00)
CTDSP1 4 (1%) 265 0.526
(1.00) 		0.266
(1.00) 		1
(1.00) 		3.03e-05
(0.0576) 		1
(1.00) 		0.325
(1.00)
PIK3R1 17 (6%) 252 0.702
(1.00) 		0.848
(1.00) 		1
(1.00) 		0.682
(1.00) 		0.29
(1.00) 		0.22
(1.00)
BID 4 (1%) 265 0.00297
(1.00) 		0.888
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.114
(1.00) 		1
(1.00)
C7ORF52 6 (2%) 263 0.493
(1.00) 		0.382
(1.00) 		1
(1.00) 		0.49
(1.00) 		0.667
(1.00) 		0.697
(1.00)
CRYBA2 6 (2%) 263 0.0639
(1.00) 		0.0518
(1.00) 		1
(1.00) 		0.739
(1.00) 		0.667
(1.00) 		0.697
(1.00)
EGFR 53 (20%) 216 0.887
(1.00) 		0.61
(1.00) 		0.873
(1.00) 		0.825
(1.00) 		1
(1.00) 		1
(1.00)
FOXC1 4 (1%) 265 0.214
(1.00) 		0.633
(1.00) 		0.618
(1.00) 		1
(1.00) 		1
(1.00)
KRTAP5-5 16 (6%) 253 0.0204
(1.00) 		0.633
(1.00) 		1
(1.00) 		0.485
(1.00) 		0.42
(1.00) 		0.796
(1.00)
MICALCL 12 (4%) 257 0.272
(1.00) 		0.699
(1.00) 		0.547
(1.00) 		0.0089
(1.00) 		0.756
(1.00) 		1
(1.00)
MRM1 4 (1%) 265 0.155
(1.00) 		0.595
(1.00) 		1
(1.00) 		0.606
(1.00) 		1
(1.00)
PIK3CA 19 (7%) 250 0.203
(1.00) 		0.752
(1.00) 		0.322
(1.00) 		0.0193
(1.00) 		0.315
(1.00) 		0.634
(1.00)
PTEN 77 (29%) 192 0.619
(1.00) 		0.0694
(1.00) 		0.889
(1.00) 		0.0373
(1.00) 		0.318
(1.00) 		0.222
(1.00)
SALL2 4 (1%) 265 0.114
(1.00) 		0.347
(1.00) 		1
(1.00) 		0.73
(1.00) 		1
(1.00) 		0.0372
(1.00)
TP53 80 (30%) 189 0.109
(1.00) 		0.769
(1.00) 		0.164
(1.00) 		0.49
(1.00) 		0.402
(1.00) 		0.107
(1.00)
RB1 20 (7%) 249 0.371
(1.00) 		0.863
(1.00) 		0.343
(1.00) 		0.408
(1.00) 		0.809
(1.00) 		0.485
(1.00)
SPTA1 26 (10%) 243 0.152
(1.00) 		0.873
(1.00) 		0.52
(1.00) 		0.782
(1.00) 		1
(1.00) 		0.406
(1.00)
FOXRED1 9 (3%) 260 0.973
(1.00) 		0.338
(1.00) 		0.0731
(1.00) 		0.415
(1.00) 		0.492
(1.00) 		0.735
(1.00)
NF1 24 (9%) 245 0.381
(1.00) 		0.359
(1.00) 		1
(1.00) 		0.443
(1.00) 		0.498
(1.00) 		0.289
(1.00)
COMMD4 5 (2%) 264 0.0397
(1.00) 		0.85
(1.00) 		0.164
(1.00) 		0.959
(1.00) 		0.665
(1.00) 		1
(1.00)
RYR2 28 (10%) 241 0.606
(1.00) 		0.614
(1.00) 		0.1
(1.00) 		0.257
(1.00) 		0.297
(1.00) 		0.551
(1.00)
PLA2G2A 5 (2%) 264 0.0228
(1.00) 		0.0212
(1.00) 		0.658
(1.00) 		0.346
(1.00) 		0.0462
(1.00) 		0.174
(1.00)
NRBP2 4 (1%) 265 0.144
(1.00) 		0.977
(1.00) 		0.3
(1.00) 		0.576
(1.00) 		0.303
(1.00) 		1
(1.00)
FUT7 5 (2%) 264 0.887
(1.00) 		0.157
(1.00) 		0.164
(1.00) 		0.438
(1.00) 		1
(1.00) 		0.174
(1.00)
FLG 27 (10%) 242 0.908
(1.00) 		0.875
(1.00) 		1
(1.00) 		0.901
(1.00) 		0.83
(1.00) 		1
(1.00)
HMP19 5 (2%) 264 0.901
(1.00) 		0.562
(1.00) 		0.658
(1.00) 		0.776
(1.00) 		0.34
(1.00) 		0.387
(1.00)
DNASE1L1 6 (2%) 263 0.822
(1.00) 		0.576
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
KDSR 5 (2%) 264 0.447
(1.00) 		0.245
(1.00) 		0.658
(1.00) 		0.386
(1.00) 		0.34
(1.00) 		0.658
(1.00)
TMEM45A 5 (2%) 264 0.165
(1.00) 		0.776
(1.00) 		0.352
(1.00) 		0.929
(1.00) 		1
(1.00) 		1
(1.00)
MUC2 15 (6%) 254 0.277
(1.00) 		0.584
(1.00) 		0.784
(1.00) 		0.221
(1.00) 		0.78
(1.00) 		0.594
(1.00)
EML2 8 (3%) 261 0.283
(1.00) 		0.363
(1.00) 		1
(1.00) 		0.222
(1.00) 		0.449
(1.00) 		0.308
(1.00)
MST1 9 (3%) 260 0.364
(1.00) 		0.776
(1.00) 		0.725
(1.00) 		0.266
(1.00) 		0.492
(1.00) 		0.735
(1.00)
KEL 12 (4%) 257 0.5
(1.00) 		0.444
(1.00) 		0.358
(1.00) 		0.0131
(1.00) 		0.229
(1.00) 		0.14
(1.00)
TMEM155 3 (1%) 266 0.262
(1.00) 		0.65
(1.00) 		1
(1.00) 		0.73
(1.00) 		0.265
(1.00) 		1
(1.00)
PRMT6 5 (2%) 264 0.0871
(1.00) 		0.309
(1.00) 		1
(1.00) 		0.34
(1.00) 		0.387
(1.00)
IRF5 5 (2%) 264 0.244
(1.00) 		0.611
(1.00) 		0.658
(1.00) 		0.229
(1.00) 		1
(1.00) 		1
(1.00)
ADAM29 9 (3%) 260 0.795
(1.00) 		0.136
(1.00) 		0.164
(1.00) 		0.757
(1.00) 		0.722
(1.00) 		0.0471
(1.00)
GABRA6 9 (3%) 260 0.123
(1.00) 		0.341
(1.00) 		0.725
(1.00) 		0.748
(1.00) 		1
(1.00) 		0.306
(1.00)
SVOP 3 (1%) 266 0.327
(1.00) 		0.292
(1.00) 		0.555
(1.00) 		0.553
(1.00) 		1
(1.00)
CALN1 9 (3%) 260 0.0625
(1.00) 		0.979
(1.00) 		0.725
(1.00) 		0.234
(1.00) 		0.722
(1.00) 		0.306
(1.00)
RIMS2 14 (5%) 255 0.492
(1.00) 		0.322
(1.00) 		0.391
(1.00) 		0.0145
(1.00) 		1
(1.00) 		0.277
(1.00)
ADRA2B 6 (2%) 263 0.486
(1.00) 		0.636
(1.00) 		0.67
(1.00) 		0.45
(1.00) 		0.667
(1.00) 		0.411
(1.00)
CNTNAP2 14 (5%) 255 0.929
(1.00) 		0.421
(1.00) 		0.576
(1.00) 		0.0905
(1.00) 		0.0392
(1.00) 		1
(1.00)
IL17RA 8 (3%) 261 0.695
(1.00) 		0.182
(1.00) 		0.716
(1.00) 		0.493
(1.00) 		0.721
(1.00) 		0.0808
(1.00)
GJD4 3 (1%) 266 0.14
(1.00) 		0.649
(1.00) 		1
(1.00) 		0.265
(1.00) 		0.585
(1.00)
FBLN2 9 (3%) 260 0.958
(1.00) 		0.344
(1.00) 		1
(1.00) 		0.308
(1.00) 		0.722
(1.00) 		0.735
(1.00)
CEACAM16 7 (3%) 262 0.823
(1.00) 		0.268
(1.00) 		0.252
(1.00) 		0.296
(1.00) 		1
(1.00) 		1
(1.00)
BBS1 8 (3%) 261 0.954
(1.00) 		0.0348
(1.00) 		1
(1.00) 		0.0597
(1.00) 		1
(1.00) 		0.308
(1.00)
GPR135 3 (1%) 266 0.865
(1.00) 		0.806
(1.00) 		1
(1.00) 		0.515
(1.00) 		0.553
(1.00) 		0.257
(1.00)
CDH18 10 (4%) 259 0.0408
(1.00) 		0.782
(1.00) 		0.336
(1.00) 		0.773
(1.00) 		0.738
(1.00) 		0.345
(1.00)
DAZAP1 3 (1%) 266 0.567
(1.00) 		0.14
(1.00) 		0.555
(1.00) 		0.265
(1.00) 		1
(1.00)
C22ORF32 4 (1%) 265 0.571
(1.00) 		0.701
(1.00) 		0.618
(1.00) 		0.572
(1.00) 		1
(1.00) 		1
(1.00)
RIC3 3 (1%) 266 0.309
(1.00) 		0.661
(1.00) 		0.29
(1.00) 		1
(1.00) 		1
(1.00)
HEATR7B2 12 (4%) 257 0.291
(1.00) 		0.84
(1.00) 		1
(1.00) 		0.267
(1.00) 		1
(1.00) 		1
(1.00)
RNF34 3 (1%) 266 0.051
(1.00) 		0.612
(1.00) 		1
(1.00) 		0.265
(1.00) 		0.585
(1.00)
MFAP4 3 (1%) 266 0.979
(1.00) 		0.553
(1.00) 		0.29
(1.00) 		0.553
(1.00) 		0.257
(1.00)
OR5D13 7 (3%) 262 0.306
(1.00) 		0.885
(1.00) 		0.101
(1.00) 		0.0399
(1.00) 		0.429
(1.00) 		0.138
(1.00)
HCN1 10 (4%) 259 0.0208
(1.00) 		0.13
(1.00) 		0.174
(1.00) 		0.346
(1.00) 		0.0342
(1.00) 		0.345
(1.00)
C9ORF150 6 (2%) 263 0.694
(1.00) 		0.144
(1.00) 		1
(1.00) 		0.023
(1.00) 		1
(1.00) 		0.697
(1.00)
NPL 3 (1%) 266 0.53
(1.00) 		0.206
(1.00) 		0.29
(1.00) 		0.265
(1.00) 		1
(1.00)
SLCO6A1 10 (4%) 259 0.785
(1.00) 		0.671
(1.00) 		1
(1.00) 		0.355
(1.00) 		0.503
(1.00) 		1
(1.00)
POTEB 9 (3%) 260 0.577
(1.00) 		0.803
(1.00) 		1
(1.00) 		0.971
(1.00) 		0.492
(1.00) 		0.515
(1.00)
BRAF 5 (2%) 264 0.335
(1.00) 		0.487
(1.00) 		0.352
(1.00) 		0.0938
(1.00) 		1
(1.00) 		0.387
(1.00)
CD4 3 (1%) 266 0.295
(1.00) 		0.7
(1.00) 		0.555
(1.00) 		0.73
(1.00) 		0.265
(1.00) 		1
(1.00)
PCLO 18 (7%) 251 0.224
(1.00) 		0.998
(1.00) 		0.451
(1.00) 		0.156
(1.00) 		0.317
(1.00) 		0.219
(1.00)
SUSD3 6 (2%) 263 0.887
(1.00) 		0.0668
(1.00) 		1
(1.00) 		0.903
(1.00) 		0.667
(1.00) 		0.232
(1.00)
FAM113B 3 (1%) 266 0.638
(1.00) 		0.727
(1.00) 		0.29
(1.00) 		1
(1.00) 		0.585
(1.00)
OR5AR1 4 (1%) 265 0.395
(1.00) 		0.0254
(1.00) 		0.618
(1.00) 		0.12
(1.00) 		0.606
(1.00) 		0.132
(1.00)
SPNS1 3 (1%) 266 0.477
(1.00) 		0.606
(1.00) 		0.555
(1.00) 		0.229
(1.00) 		1
(1.00) 		1
(1.00)
TTN 61 (23%) 208 0.379
(1.00) 		0.824
(1.00) 		1
(1.00) 		0.0308
(1.00) 		1
(1.00) 		0.146
(1.00)
LPHN1 10 (4%) 259 0.337
(1.00) 		0.0921
(1.00) 		1
(1.00) 		0.00369
(1.00) 		1
(1.00) 		0.754
(1.00)
CC2D1A 9 (3%) 260 0.998
(1.00) 		0.845
(1.00) 		1
(1.00) 		0.328
(1.00) 		0.722
(1.00) 		1
(1.00)
GABRB2 7 (3%) 262 0.213
(1.00) 		0.00863
(1.00) 		0.252
(1.00) 		0.45
(1.00) 		0.231
(1.00) 		1
(1.00)
SEMG1 8 (3%) 261 0.682
(1.00) 		0.78
(1.00) 		0.462
(1.00) 		0.146
(1.00) 		0.125
(1.00) 		0.144
(1.00)
STAG2 10 (4%) 259 0.676
(1.00) 		0.144
(1.00) 		0.174
(1.00) 		0.0293
(1.00) 		1
(1.00) 		0.754
(1.00)
FAM83H 10 (4%) 259 0.877
(1.00) 		0.825
(1.00) 		0.336
(1.00) 		0.115
(1.00) 		1
(1.00) 		0.52
(1.00)
TRPM2 10 (4%) 259 0.602
(1.00) 		0.552
(1.00) 		0.748
(1.00) 		0.509
(1.00) 		0.503
(1.00) 		0.754
(1.00)
WSCD2 5 (2%) 264 0.0782
(1.00) 		0.824
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		0.658
(1.00)
DUS3L 7 (3%) 262 0.687
(1.00) 		0.783
(1.00) 		1
(1.00) 		0.379
(1.00) 		1
(1.00) 		1
(1.00)
ACSM4 7 (3%) 262 0.0785
(1.00) 		0.417
(1.00) 		0.252
(1.00) 		0.415
(1.00) 		1
(1.00) 		0.469
(1.00)
CDH9 9 (3%) 260 0.365
(1.00) 		0.123
(1.00) 		0.725
(1.00) 		0.653
(1.00) 		0.722
(1.00) 		1
(1.00)
ZMYM3 10 (4%) 259 0.463
(1.00) 		0.0702
(1.00) 		1
(1.00) 		0.00888
(1.00) 		0.503
(1.00) 		0.52
(1.00)
MUC16 33 (12%) 236 0.287
(1.00) 		0.74
(1.00) 		0.439
(1.00) 		0.731
(1.00) 		0.699
(1.00) 		0.854
(1.00)
MAGEB1 6 (2%) 263 0.289
(1.00) 		0.153
(1.00) 		1
(1.00) 		0.508
(1.00) 		0.667
(1.00) 		0.232
(1.00)
ZFP42 7 (3%) 262 0.516
(1.00) 		0.68
(1.00) 		0.252
(1.00) 		0.508
(1.00) 		1
(1.00) 		1
(1.00)
TMEM132D 10 (4%) 259 0.379
(1.00) 		0.902
(1.00) 		0.00478
(1.00) 		0.59
(1.00) 		0.0925
(1.00) 		0.754
(1.00)
LRRC55 6 (2%) 263 0.728
(1.00) 		0.278
(1.00) 		1
(1.00) 		0.0938
(1.00) 		1
(1.00) 		0.697
(1.00)
COL5A3 9 (3%) 260 0.424
(1.00) 		0.394
(1.00) 		0.725
(1.00) 		0.334
(1.00) 		0.281
(1.00) 		0.306
(1.00)
DNMT3L 6 (2%) 263 0.988
(1.00) 		0.515
(1.00) 		0.0917
(1.00) 		0.947
(1.00) 		0.667
(1.00) 		0.697
(1.00)
FBF1 4 (1%) 265 0.538
(1.00) 		0.779
(1.00) 		1
(1.00) 		1
(1.00) 		0.325
(1.00)
KIF21B 9 (3%) 260 0.111
(1.00) 		0.511
(1.00) 		0.498
(1.00) 		0.0597
(1.00) 		1
(1.00) 		0.515
(1.00)
GRM3 8 (3%) 261 0.694
(1.00) 		0.0435
(1.00) 		1
(1.00) 		0.692
(1.00) 		0.0545
(1.00) 		0.00987
(1.00)
NAPRT1 4 (1%) 265 0.395
(1.00) 		0.517
(1.00) 		1
(1.00) 		0.146
(1.00) 		0.606
(1.00) 		1
(1.00)
UBE2M 3 (1%) 266 0.27
(1.00) 		0.915
(1.00) 		0.555
(1.00) 		0.229
(1.00) 		0.265
(1.00) 		1
(1.00)
ADAMTS16 10 (4%) 259 0.0593
(1.00) 		0.763
(1.00) 		0.336
(1.00) 		0.0403
(1.00) 		0.503
(1.00) 		0.113
(1.00)
PLXNB2 6 (2%) 263 0.623
(1.00) 		0.0277
(1.00) 		1
(1.00) 		0.248
(1.00) 		0.41
(1.00) 		1
(1.00)
GABRA1 7 (3%) 262 0.724
(1.00) 		0.307
(1.00) 		1
(1.00) 		0.0938
(1.00) 		1
(1.00) 		0.138
(1.00)
PRIM2 5 (2%) 264 0.484
(1.00) 		0.53
(1.00) 		0.0562
(1.00) 		0.0462
(1.00) 		0.174
(1.00)
RABGGTA 4 (1%) 265 0.106
(1.00) 		0.754
(1.00) 		0.618
(1.00) 		0.635
(1.00) 		0.606
(1.00) 		0.632
(1.00)
ACVR2A 5 (2%) 264 0.983
(1.00) 		0.689
(1.00) 		1
(1.00) 		0.513
(1.00) 		0.171
(1.00) 		0.0685
(1.00)
OR5K4 4 (1%) 265 0.589
(1.00) 		0.136
(1.00) 		0.618
(1.00) 		1
(1.00) 		1
(1.00)
STARD8 7 (3%) 262 0.402
(1.00) 		0.671
(1.00) 		0.252
(1.00) 		0.383
(1.00) 		0.692
(1.00) 		0.469
(1.00)
FAM132A 4 (1%) 265 0.356
(1.00) 		0.19
(1.00) 		0.618
(1.00) 		1
(1.00) 		0.632
(1.00)
CPNE3 3 (1%) 266 0.793
(1.00) 		0.847
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
SIM2 6 (2%) 263 0.148
(1.00) 		0.312
(1.00) 		0.426
(1.00) 		0.681
(1.00) 		1
(1.00) 		0.697
(1.00)
MAGEB4 5 (2%) 264 0.159
(1.00) 		0.309
(1.00) 		0.0562
(1.00) 		0.0938
(1.00) 		1
(1.00) 		0.658
(1.00)
DND1 4 (1%) 265 0.744
(1.00) 		0.145
(1.00) 		0.618
(1.00) 		0.528
(1.00) 		1
(1.00) 		0.632
(1.00)
ACRC 6 (2%) 263 0.668
(1.00) 		0.505
(1.00) 		0.67
(1.00) 		0.559
(1.00) 		1
(1.00) 		0.697
(1.00)
TRAT1 5 (2%) 264 0.6
(1.00) 		0.658
(1.00) 		1
(1.00) 		0.407
(1.00) 		0.665
(1.00) 		0.387
(1.00)
PCSK4 5 (2%) 264 0.944
(1.00) 		0.288
(1.00) 		0.00541
(1.00) 		0.614
(1.00) 		0.34
(1.00) 		1
(1.00)
ZNF208 8 (3%) 261 0.612
(1.00) 		0.26
(1.00) 		0.0261
(1.00) 		0.163
(1.00) 		0.449
(1.00) 		0.735
(1.00)
SEMA3C 8 (3%) 261 0.0409
(1.00) 		0.902
(1.00) 		0.716
(1.00) 		0.805
(1.00) 		0.449
(1.00) 		0.473
(1.00)
SARDH 5 (2%) 264 0.425
(1.00) 		0.577
(1.00) 		0.658
(1.00) 		0.13
(1.00) 		0.171
(1.00) 		1
(1.00)
ABCC9 9 (3%) 260 0.742
(1.00) 		0.603
(1.00) 		0.725
(1.00) 		0.555
(1.00) 		0.492
(1.00) 		0.306
(1.00)
PODNL1 3 (1%) 266 0.0673
(1.00) 		0.0372
(1.00) 		1
(1.00) 		0.265
(1.00) 		0.585
(1.00)
POM121L12 7 (3%) 262 0.661
(1.00) 		0.379
(1.00) 		0.101
(1.00) 		0.513
(1.00) 		1
(1.00) 		0.138
(1.00)
SVOPL 4 (1%) 265 0.56
(1.00) 		0.383
(1.00) 		0.131
(1.00) 		0.303
(1.00) 		0.132
(1.00)
HNF4A 6 (2%) 263 0.877
(1.00) 		0.47
(1.00) 		0.191
(1.00) 		0.559
(1.00) 		0.667
(1.00) 		1
(1.00)
CKMT1A 3 (1%) 266 0.437
(1.00) 		0.0472
(1.00) 		0.555
(1.00) 		0.84
(1.00) 		1
(1.00) 		0.585
(1.00)
GAK 6 (2%) 263 0.0716
(1.00) 		0.961
(1.00) 		1
(1.00) 		0.513
(1.00) 		1
(1.00) 		0.232
(1.00)
TRHDE 8 (3%) 261 0.573
(1.00) 		0.972
(1.00) 		0.462
(1.00) 		0.631
(1.00) 		0.721
(1.00) 		1
(1.00)
SLCO5A1 6 (2%) 263 0.874
(1.00) 		0.914
(1.00) 		0.191
(1.00) 		0.0806
(1.00) 		0.41
(1.00) 		0.411
(1.00)
SCN9A 11 (4%) 258 0.259
(1.00) 		0.84
(1.00) 		0.751
(1.00) 		0.888
(1.00) 		0.517
(1.00) 		1
(1.00)
ARHGEF2 6 (2%) 263 0.732
(1.00) 		0.36
(1.00) 		0.67
(1.00) 		0.296
(1.00) 		0.41
(1.00) 		0.697
(1.00)
TPTE2 6 (2%) 263 0.322
(1.00) 		0.796
(1.00) 		0.67
(1.00) 		0.415
(1.00) 		0.184
(1.00) 		0.411
(1.00)
NPR1 6 (2%) 263 0.405
(1.00) 		0.113
(1.00) 		0.67
(1.00) 		0.0938
(1.00) 		1
(1.00) 		0.0357
(1.00)
GLT8D2 4 (1%) 265 0.0521
(1.00) 		0.2
(1.00) 		0.618
(1.00) 		0.114
(1.00) 		0.325
(1.00)
QKI 5 (2%) 264 0.782
(1.00) 		0.669
(1.00) 		1
(1.00) 		0.882
(1.00) 		0.34
(1.00) 		1
(1.00)
DOCK5 11 (4%) 258 0.478
(1.00) 		0.476
(1.00) 		1
(1.00) 		0.888
(1.00) 		1
(1.00) 		0.545
(1.00)
LRFN5 7 (3%) 262 0.714
(1.00) 		0.831
(1.00) 		0.252
(1.00) 		0.959
(1.00) 		0.231
(1.00) 		1
(1.00)
ANO2 9 (3%) 260 0.0902
(1.00) 		0.302
(1.00) 		0.725
(1.00) 		0.35
(1.00) 		0.171
(1.00) 		1
(1.00)
ASB2 4 (1%) 265 0.382
(1.00) 		0.327
(1.00) 		0.3
(1.00) 		0.759
(1.00) 		0.606
(1.00) 		0.325
(1.00)
CDC42EP1 3 (1%) 266 0.0716
(1.00) 		0.125
(1.00) 		0.555
(1.00) 		0.515
(1.00) 		1
(1.00) 		0.585
(1.00)
LGALS9B 3 (1%) 266 0.475
(1.00) 		0.493
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
COL6A3 17 (6%) 252 0.193
(1.00) 		0.236
(1.00) 		0.611
(1.00) 		0.354
(1.00) 		1
(1.00) 		0.615
(1.00)
OBSCN 23 (9%) 246 0.231
(1.00) 		0.889
(1.00) 		0.11
(1.00) 		0.264
(1.00) 		0.495
(1.00) 		1
(1.00)
OR52M1 6 (2%) 263 0.537
(1.00) 		0.0862
(1.00) 		0.67
(1.00) 		0.638
(1.00) 		0.0995
(1.00) 		0.0357
(1.00)
PRDM12 4 (1%) 265 0.825
(1.00) 		0.423
(1.00) 		1
(1.00) 		0.606
(1.00) 		0.325
(1.00)
RARA 5 (2%) 264 0.968
(1.00) 		0.508
(1.00) 		1
(1.00) 		0.195
(1.00) 		0.34
(1.00) 		0.658
(1.00)
ZPBP 5 (2%) 264 0.56
(1.00) 		0.496
(1.00) 		0.0562
(1.00) 		0.929
(1.00) 		1
(1.00) 		1
(1.00)
KCNN2 4 (1%) 265 0.667
(1.00) 		0.59
(1.00) 		0.618
(1.00) 		0.128
(1.00) 		0.303
(1.00) 		0.632
(1.00)
OR8K3 4 (1%) 265 0.742
(1.00) 		0.711
(1.00) 		0.618
(1.00) 		0.146
(1.00) 		0.303
(1.00) 		0.132
(1.00)
MYH2 9 (3%) 260 0.0239
(1.00) 		0.699
(1.00) 		0.725
(1.00) 		0.0336
(1.00) 		1
(1.00) 		0.515
(1.00)
OR4C12 4 (1%) 265 0.938
(1.00) 		0.345
(1.00) 		0.3
(1.00) 		0.759
(1.00) 		0.606
(1.00) 		0.132
(1.00)
SLC6A3 8 (3%) 261 0.137
(1.00) 		0.97
(1.00) 		1
(1.00) 		0.631
(1.00) 		1
(1.00) 		0.308
(1.00)
SMR3B 3 (1%) 266 0.237
(1.00) 		0.224
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
KLHL34 6 (2%) 263 0.92
(1.00) 		0.812
(1.00) 		0.191
(1.00) 		0.631
(1.00) 		1
(1.00) 		1
(1.00)
PIK3C2G 7 (3%) 262 0.126
(1.00) 		0.427
(1.00) 		0.00922
(1.00) 		0.146
(1.00) 		0.046
(1.00) 		0.703
(1.00)
TNFSF11 4 (1%) 265 0.685
(1.00) 		0.182
(1.00) 		0.618
(1.00) 		0.73
(1.00) 		0.606
(1.00) 		1
(1.00)
UBASH3A 7 (3%) 262 0.973
(1.00) 		0.356
(1.00) 		0.703
(1.00) 		0.111
(1.00) 		0.429
(1.00) 		0.138
(1.00)
KRT222 3 (1%) 266 0.82
(1.00) 		0.711
(1.00) 		0.0445
(1.00) 		1
(1.00) 		1
(1.00)
OR9G4 5 (2%) 264 0.119
(1.00) 		0.56
(1.00) 		0.0562
(1.00) 		0.695
(1.00) 		1
(1.00) 		0.387
(1.00)
ECEL1 6 (2%) 263 0.426
(1.00) 		0.375
(1.00) 		0.67
(1.00) 		0.513
(1.00) 		0.0995
(1.00) 		0.411
(1.00)
TPTE 6 (2%) 263 0.167
(1.00) 		0.387
(1.00) 		1
(1.00) 		0.576
(1.00) 		0.41
(1.00) 		1
(1.00)
DUSP27 8 (3%) 261 0.343
(1.00) 		0.918
(1.00) 		0.462
(1.00) 		0.739
(1.00) 		0.125
(1.00) 		0.735
(1.00)
TRPV6 7 (3%) 262 0.552
(1.00) 		0.215
(1.00) 		0.252
(1.00) 		0.415
(1.00) 		1
(1.00) 		0.469
(1.00)
SCN7A 7 (3%) 262 0.0737
(1.00) 		0.659
(1.00) 		0.703
(1.00) 		0.756
(1.00) 		0.692
(1.00) 		0.469
(1.00)
DPPA4 5 (2%) 264 0.354
(1.00) 		0.35
(1.00) 		0.658
(1.00) 		0.903
(1.00) 		1
(1.00) 		1
(1.00)
OR8H3 3 (1%) 266 0.214
(1.00) 		0.586
(1.00) 		0.29
(1.00) 		0.759
(1.00) 		1
(1.00) 		0.257
(1.00)
F9 4 (1%) 265 0.197
(1.00) 		0.424
(1.00) 		1
(1.00) 		1
(1.00) 		0.325
(1.00)
SLC27A2 7 (3%) 262 0.466
(1.00) 		0.43
(1.00) 		1
(1.00) 		0.903
(1.00) 		0.429
(1.00) 		0.138
(1.00)
UGT3A2 6 (2%) 263 0.147
(1.00) 		0.945
(1.00) 		0.0231
(1.00) 		0.929
(1.00) 		1
(1.00) 		1
(1.00)
FTMT 5 (2%) 264 0.812
(1.00) 		0.66
(1.00) 		0.352
(1.00) 		0.929
(1.00) 		0.34
(1.00) 		1
(1.00)
OR51A2 3 (1%) 266 0.307
(1.00) 		0.0742
(1.00) 		0.555
(1.00) 		0.553
(1.00) 		0.257
(1.00)
NCOA4 3 (1%) 266 0.637
(1.00) 		0.919
(1.00) 		1
(1.00) 		0.311
(1.00) 		0.553
(1.00) 		0.257
(1.00)
GABRE 6 (2%) 263 0.473
(1.00) 		0.834
(1.00) 		0.67
(1.00) 		0.407
(1.00) 		0.184
(1.00) 		0.697
(1.00)
ELMO1 7 (3%) 262 0.536
(1.00) 		0.631
(1.00) 		0.703
(1.00) 		0.0597
(1.00) 		1
(1.00) 		1
(1.00)
CXORF22 8 (3%) 261 0.0287
(1.00) 		0.594
(1.00) 		1
(1.00) 		0.266
(1.00) 		0.721
(1.00) 		1
(1.00)
FLG2 11 (4%) 258 0.212
(1.00) 		0.224
(1.00) 		0.337
(1.00) 		0.65
(1.00) 		0.517
(1.00) 		1
(1.00)
TCN1 4 (1%) 265 0.763
(1.00) 		0.284
(1.00) 		0.618
(1.00) 		0.114
(1.00) 		1
(1.00)
CHD5 8 (3%) 261 0.233
(1.00) 		0.269
(1.00) 		0.138
(1.00) 		0.297
(1.00) 		0.721
(1.00) 		0.308
(1.00)
LRP2 20 (7%) 249 0.659
(1.00) 		0.405
(1.00) 		0.343
(1.00) 		0.45
(1.00) 		0.809
(1.00) 		0.816
(1.00)
PRDM9 8 (3%) 261 0.49
(1.00) 		0.695
(1.00) 		0.462
(1.00) 		0.929
(1.00) 		1
(1.00) 		0.735
(1.00)
PAN3 6 (2%) 263 0.765
(1.00) 		0.314
(1.00) 		1
(1.00) 		0.616
(1.00) 		1
(1.00) 		0.0357
(1.00)
SLIT3 12 (4%) 257 0.293
(1.00) 		0.275
(1.00) 		0.123
(1.00) 		0.0234
(1.00) 		0.229
(1.00) 		0.77
(1.00)
WNT2 5 (2%) 264 0.773
(1.00) 		0.577
(1.00) 		0.352
(1.00) 		0.407
(1.00) 		0.0462
(1.00) 		0.387
(1.00)
UFSP1 3 (1%) 266 0.702
(1.00) 		0.563
(1.00) 		1
(1.00) 		0.553
(1.00) 		0.585
(1.00)
TRIM72 4 (1%) 265 0.141
(1.00) 		0.863
(1.00) 		1
(1.00) 		0.971
(1.00) 		1
(1.00) 		0.632
(1.00)
OR7G2 5 (2%) 264 0.000983
(1.00) 		0.909
(1.00) 		1
(1.00) 		0.407
(1.00) 		0.34
(1.00) 		1
(1.00)
CYP4F22 5 (2%) 264 0.624
(1.00) 		0.921
(1.00) 		1
(1.00) 		0.331
(1.00) 		1
(1.00) 		0.658
(1.00)
PDGFRA 8 (3%) 261 0.565
(1.00) 		0.817
(1.00) 		0.266
(1.00) 		0.838
(1.00) 		0.449
(1.00) 		0.308
(1.00)
LGI2 4 (1%) 265 0.435
(1.00) 		0.676
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.303
(1.00) 		0.632
(1.00)
ALS2CR11 5 (2%) 264 0.0535
(1.00) 		0.761
(1.00) 		0.658
(1.00) 		0.407
(1.00) 		1
(1.00) 		0.387
(1.00)
KPRP 7 (3%) 262 0.688
(1.00) 		0.144
(1.00) 		0.252
(1.00) 		0.508
(1.00) 		1
(1.00) 		0.703
(1.00)
ZFHX4 7 (3%) 262 0.916
(1.00) 		0.376
(1.00) 		0.00922
(1.00) 		0.739
(1.00) 		0.692
(1.00) 		1
(1.00)
SRCRB4D 5 (2%) 264 0.134
(1.00) 		0.142
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
CLCN7 3 (1%) 266 0.643
(1.00) 		0.167
(1.00) 		1
(1.00) 		0.515
(1.00) 		0.553
(1.00) 		1
(1.00)
EPHA1 6 (2%) 263 0.601
(1.00) 		0.841
(1.00) 		1
(1.00) 		0.229
(1.00) 		0.667
(1.00) 		0.697
(1.00)
UBE2NL 3 (1%) 266 0.939
(1.00) 		0.0492
(1.00) 		0.29
(1.00) 		1
(1.00) 		1
(1.00)
TGM2 7 (3%) 262 0.445
(1.00) 		0.261
(1.00) 		0.703
(1.00) 		0.541
(1.00) 		0.231
(1.00) 		0.469
(1.00)
OR4D5 4 (1%) 265 0.53
(1.00) 		0.0949
(1.00) 		0.3
(1.00) 		0.759
(1.00) 		0.114
(1.00) 		1
(1.00)
FAM123C 6 (2%) 263 0.463
(1.00) 		0.016
(1.00) 		0.426
(1.00) 		0.0938
(1.00) 		0.41
(1.00) 		0.411
(1.00)
MBIP 3 (1%) 266 0.346
(1.00) 		0.465
(1.00) 		0.0445
(1.00) 		0.229
(1.00) 		0.553
(1.00) 		0.257
(1.00)
EEF1A1 5 (2%) 264 0.76
(1.00) 		0.532
(1.00) 		0.0562
(1.00) 		0.903
(1.00) 		1
(1.00) 		1
(1.00)
OR4P4 4 (1%) 265 0.27
(1.00) 		0.932
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.303
(1.00) 		1
(1.00)
SYDE2 4 (1%) 265 0.00793
(1.00) 		0.333
(1.00) 		0.618
(1.00) 		0.929
(1.00) 		0.606
(1.00) 		1
(1.00)
UGT2B28 5 (2%) 264 0.592
(1.00) 		0.583
(1.00) 		0.658
(1.00) 		0.576
(1.00) 		1
(1.00) 		0.174
(1.00)
TRIML1 7 (3%) 262 0.699
(1.00) 		0.317
(1.00) 		0.101
(1.00) 		0.776
(1.00) 		0.692
(1.00) 		0.703
(1.00)
ARHGAP9 7 (3%) 262 0.525
(1.00) 		0.932
(1.00) 		1
(1.00) 		0.0806
(1.00) 		0.231
(1.00) 		0.247
(1.00)
CALCR 6 (2%) 263 0.597
(1.00) 		0.54
(1.00) 		1
(1.00) 		0.959
(1.00) 		1
(1.00) 		0.232
(1.00)
ZNF711 5 (2%) 264 0.88
(1.00) 		0.713
(1.00) 		0.658
(1.00) 		0.929
(1.00) 		1
(1.00) 		0.387
(1.00)
CTSG 4 (1%) 265 0.636
(1.00) 		0.479
(1.00) 		0.618
(1.00) 		0.606
(1.00) 		0.325
(1.00)
FOXN4 3 (1%) 266 0.494
(1.00) 		0.125
(1.00) 		0.29
(1.00) 		1
(1.00) 		1
(1.00)
HIST1H2AG 3 (1%) 266 0.327
(1.00) 		0.611
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00)
AADACL4 5 (2%) 264 0.524
(1.00) 		0.327
(1.00) 		0.658
(1.00) 		0.146
(1.00) 		0.171
(1.00) 		0.658
(1.00)
NEU4 4 (1%) 265 0.166
(1.00) 		0.926
(1.00) 		0.131
(1.00) 		0.614
(1.00) 		0.303
(1.00) 		0.132
(1.00)
MICAL1 4 (1%) 265 0.524
(1.00) 		0.254
(1.00) 		0.131
(1.00) 		0.146
(1.00) 		1
(1.00) 		0.632
(1.00)
LGSN 6 (2%) 263 0.208
(1.00) 		0.924
(1.00) 		0.67
(1.00) 		0.234
(1.00) 		1
(1.00) 		0.232
(1.00)
CHL1 8 (3%) 261 0.995
(1.00) 		0.315
(1.00) 		0.716
(1.00) 		0.279
(1.00) 		1
(1.00) 		0.308
(1.00)
OR2T27 4 (1%) 265 0.735
(1.00) 		0.988
(1.00) 		0.131
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
DDX11 6 (2%) 263 0.193
(1.00) 		0.635
(1.00) 		0.67
(1.00) 		0.614
(1.00) 		1
(1.00) 		1
(1.00)
ITK 3 (1%) 266 0.709
(1.00) 		0.16
(1.00) 		0.29
(1.00) 		0.553
(1.00) 		0.257
(1.00)
THSD7B 7 (3%) 262 0.0477
(1.00) 		0.0359
(1.00) 		0.427
(1.00) 		0.508
(1.00) 		1
(1.00) 		1
(1.00)
PITPNM1 4 (1%) 265 0.118
(1.00) 		0.494
(1.00) 		0.0156
(1.00) 		0.606
(1.00) 		0.632
(1.00)
QPRT 3 (1%) 266 0.983
(1.00) 		0.251
(1.00) 		0.555
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
MEGF8 10 (4%) 259 0.796
(1.00) 		0.141
(1.00) 		0.336
(1.00) 		0.664
(1.00) 		0.172
(1.00) 		0.52
(1.00)
PLEKHG4B 9 (3%) 260 0.733
(1.00) 		0.866
(1.00) 		0.288
(1.00) 		0.59
(1.00) 		0.492
(1.00) 		0.515
(1.00)
ZNF493 3 (1%) 266 0.147
(1.00) 		0.402
(1.00) 		1
(1.00) 		0.553
(1.00) 		1
(1.00)
CYLC2 4 (1%) 265 0.0213
(1.00) 		0.933
(1.00) 		1
(1.00) 		0.229
(1.00) 		1
(1.00) 		0.632
(1.00)
ANKRD52 6 (2%) 263 0.716
(1.00) 		0.21
(1.00) 		1
(1.00) 		0.248
(1.00) 		0.41
(1.00) 		0.0908
(1.00)
LPAR3 3 (1%) 266 0.112
(1.00) 		0.285
(1.00) 		0.29
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
KRT23 6 (2%) 263 0.244
(1.00) 		0.0952
(1.00) 		0.0231
(1.00) 		0.756
(1.00) 		0.667
(1.00) 		0.697
(1.00)
LRRIQ1 8 (3%) 261 0.155
(1.00) 		0.933
(1.00) 		1
(1.00) 		0.115
(1.00) 		1
(1.00) 		1
(1.00)
PTPRT 9 (3%) 260 0.582
(1.00) 		0.813
(1.00) 		0.288
(1.00) 		0.59
(1.00) 		0.722
(1.00) 		0.735
(1.00)
TMPRSS6 7 (3%) 262 0.901
(1.00) 		0.973
(1.00) 		0.252
(1.00) 		0.248
(1.00) 		0.429
(1.00) 		1
(1.00)
AFM 5 (2%) 264 0.926
(1.00) 		0.447
(1.00) 		1
(1.00) 		0.929
(1.00) 		0.171
(1.00) 		0.387
(1.00)
GALK2 5 (2%) 264 0.642
(1.00) 		0.431
(1.00) 		0.658
(1.00) 		0.513
(1.00) 		0.665
(1.00) 		0.658
(1.00)
GPC4 5 (2%) 264 0.434
(1.00) 		0.182
(1.00) 		1
(1.00) 		0.885
(1.00) 		0.665
(1.00) 		1
(1.00)
OR5D18 4 (1%) 265 0.789
(1.00) 		0.406
(1.00) 		0.618
(1.00) 		0.0744
(1.00) 		0.606
(1.00) 		0.632
(1.00)
LAMA1 12 (4%) 257 0.58
(1.00) 		0.104
(1.00) 		0.358
(1.00) 		0.517
(1.00) 		0.0649
(1.00) 		0.558
(1.00)
PHLDB2 5 (2%) 264 0.37
(1.00) 		0.85
(1.00) 		1
(1.00) 		0.34
(1.00) 		0.174
(1.00)
EIF2C3 5 (2%) 264 0.523
(1.00) 		0.141
(1.00) 		1
(1.00) 		0.614
(1.00) 		0.34
(1.00) 		0.387
(1.00)
IL4R 6 (2%) 263 0.25
(1.00) 		0.706
(1.00) 		0.191
(1.00) 		0.407
(1.00) 		0.41
(1.00) 		0.697
(1.00)
SULT1B1 4 (1%) 265 0.48
(1.00) 		0.616
(1.00) 		0.618
(1.00) 		0.929
(1.00) 		1
(1.00) 		1
(1.00)
CDKN1B 3 (1%) 266 0.82
(1.00) 		0.513
(1.00) 		1
(1.00) 		0.311
(1.00) 		1
(1.00) 		0.257
(1.00)
DSG3 8 (3%) 261 0.178
(1.00) 		0.863
(1.00) 		1
(1.00) 		0.757
(1.00) 		0.721
(1.00) 		0.735
(1.00)
RAB21 3 (1%) 266 0.00705
(1.00) 		0.46
(1.00) 		0.555
(1.00) 		1
(1.00) 		1
(1.00)
TXNDC3 6 (2%) 263 0.89
(1.00) 		0.515
(1.00) 		1
(1.00) 		0.756
(1.00) 		1
(1.00) 		0.232
(1.00)
AP3S1 3 (1%) 266 0.556
(1.00) 		0.778
(1.00) 		0.555
(1.00) 		0.109
(1.00) 		1
(1.00) 		0.585
(1.00)
HYDIN 23 (9%) 246 0.494
(1.00) 		0.543
(1.00) 		0.821
(1.00) 		0.175
(1.00) 		1
(1.00) 		0.827
(1.00)
MAGEB6 5 (2%) 264 0.368
(1.00) 		0.704
(1.00) 		0.352
(1.00) 		0.346
(1.00) 		0.665
(1.00) 		0.658
(1.00)
NCCRP1 3 (1%) 266 0.407
(1.00) 		0.219
(1.00) 		0.555
(1.00) 		0.776
(1.00) 		0.265
(1.00) 		0.585
(1.00)
NUP210L 9 (3%) 260 0.982
(1.00) 		0.24
(1.00) 		0.725
(1.00) 		0.266
(1.00) 		0.722
(1.00) 		0.735
(1.00)
PIK3CG 10 (4%) 259 0.426
(1.00) 		0.733
(1.00) 		0.174
(1.00) 		0.631
(1.00) 		0.0925
(1.00) 		0.345
(1.00)
UGT2A3 3 (1%) 266 0.917
(1.00) 		0.123
(1.00) 		1
(1.00) 		0.553
(1.00) 		0.585
(1.00)
KIAA1751 7 (3%) 262 0.0248
(1.00) 		0.4
(1.00) 		1
(1.00) 		0.513
(1.00) 		1
(1.00) 		0.469
(1.00)
ACSL6 4 (1%) 265 0.227
(1.00) 		0.318
(1.00) 		1
(1.00) 		0.614
(1.00) 		0.303
(1.00) 		0.632
(1.00)
OR10A3 4 (1%) 265 0.187
(1.00) 		0.181
(1.00) 		0.618
(1.00) 		0.229
(1.00) 		0.303
(1.00) 		1
(1.00)
PCDH11X 5 (2%) 264 0.442
(1.00) 		0.11
(1.00) 		0.352
(1.00) 		0.0224
(1.00) 		0.34
(1.00) 		0.658
(1.00)
PLCB3 5 (2%) 264 0.701
(1.00) 		0.457
(1.00) 		0.0562
(1.00) 		0.346
(1.00) 		0.171
(1.00) 		0.387
(1.00)
DEFB114 3 (1%) 266 0.621
(1.00) 		0.744
(1.00) 		0.0445
(1.00) 		1
(1.00) 		0.257
(1.00)
DPP10 7 (3%) 262 0.993
(1.00) 		0.262
(1.00) 		0.252
(1.00) 		0.132
(1.00) 		1
(1.00) 		0.138
(1.00)
HOMER1 5 (2%) 264 0.758
(1.00) 		0.174
(1.00) 		0.352
(1.00) 		0.776
(1.00) 		0.665
(1.00) 		1
(1.00)
KRT19 5 (2%) 264 0.952
(1.00) 		0.935
(1.00) 		0.00541
(1.00) 		0.776
(1.00) 		0.665
(1.00) 		1
(1.00)
REPIN1 3 (1%) 266 0.177
(1.00) 		0.725
(1.00) 		0.29
(1.00) 		0.553
(1.00) 		1
(1.00)
SIGLEC9 4 (1%) 265 0.442
(1.00) 		0.717
(1.00) 		0.618
(1.00) 		0.606
(1.00) 		1
(1.00)
FLJ43860 4 (1%) 265 0.895
(1.00) 		0.54
(1.00) 		0.618
(1.00) 		0.776
(1.00) 		1
(1.00) 		0.632
(1.00)
RBMS3 5 (2%) 264 0.573
(1.00) 		0.389
(1.00) 		0.352
(1.00) 		0.963
(1.00) 		0.171
(1.00) 		1
(1.00)
OR4K13 4 (1%) 265 0.272
(1.00) 		0.459
(1.00) 		0.618
(1.00) 		0.776
(1.00) 		0.303
(1.00) 		0.632
(1.00)
OR5I1 4 (1%) 265 0.82
(1.00) 		0.118
(1.00) 		1
(1.00) 		0.776
(1.00) 		1
(1.00) 		1
(1.00)
PTGFRN 3 (1%) 266 0.113
(1.00) 		0.666
(1.00) 		0.29
(1.00) 		0.776
(1.00) 		1
(1.00) 		0.257
(1.00)
TMEM151A 3 (1%) 266 0.121
(1.00) 		0.903
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.553
(1.00) 		0.257
(1.00)
STEAP1 4 (1%) 265 0.148
(1.00) 		0.343
(1.00) 		1
(1.00) 		0.606
(1.00) 		0.632
(1.00)
MSL3 5 (2%) 264 0.591
(1.00) 		0.0888
(1.00) 		1
(1.00) 		0.407
(1.00) 		0.34
(1.00) 		0.387
(1.00)
PALM2-AKAP2 8 (3%) 261 0.392
(1.00) 		0.433
(1.00) 		0.266
(1.00) 		0.87
(1.00) 		1
(1.00) 		0.308
(1.00)
PCDH11Y 5 (2%) 264 0.983
(1.00) 		0.763
(1.00) 		0.164
(1.00) 		0.508
(1.00) 		0.0462
(1.00) 		0.658
(1.00)
ATP8A2 6 (2%) 263 0.536
(1.00) 		0.803
(1.00) 		1
(1.00) 		0.195
(1.00) 		0.41
(1.00) 		0.0908
(1.00)
KDM2B 8 (3%) 261 0.354
(1.00) 		0.169
(1.00) 		0.716
(1.00) 		0.383
(1.00) 		0.721
(1.00) 		0.308
(1.00)
KCNH5 7 (3%) 262 0.568
(1.00) 		0.705
(1.00) 		0.703
(1.00) 		0.495
(1.00) 		0.429
(1.00) 		0.138
(1.00)
PRR21 3 (1%) 266 0.471
(1.00) 		0.00892
(1.00) 		0.555
(1.00) 		0.759
(1.00) 		0.553
(1.00) 		0.257
(1.00)
FADS6 4 (1%) 265 0.34
(1.00) 		0.0402
(1.00) 		0.131
(1.00) 		0.776
(1.00) 		0.606
(1.00) 		0.325
(1.00)
NOS1 8 (3%) 261 0.512
(1.00) 		0.784
(1.00) 		0.138
(1.00) 		0.466
(1.00) 		0.721
(1.00) 		1
(1.00)
GALK1 3 (1%) 266 0.0343
(1.00) 		0.947
(1.00) 		1
(1.00) 		0.265
(1.00) 		0.585
(1.00)
GAP43 3 (1%) 266 0.742
(1.00) 		0.156
(1.00) 		0.555
(1.00) 		0.109
(1.00) 		1
(1.00) 		0.257
(1.00)
GFM1 3 (1%) 266 0.788
(1.00) 		0.386
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.553
(1.00) 		0.257
(1.00)
KIF2B 7 (3%) 262 0.289
(1.00) 		0.539
(1.00) 		0.101
(1.00) 		0.739
(1.00) 		1
(1.00) 		0.469
(1.00)
FANK1 4 (1%) 265 0.682
(1.00) 		0.954
(1.00) 		0.618
(1.00) 		0.776
(1.00) 		0.114
(1.00) 		0.325
(1.00)
TMTC1 6 (2%) 263 0.641
(1.00) 		0.0482
(1.00) 		0.67
(1.00) 		0.0938
(1.00) 		0.41
(1.00) 		0.411
(1.00)
CCDC120 4 (1%) 265 0.935
(1.00) 		0.483
(1.00) 		0.618
(1.00) 		1
(1.00) 		1
(1.00)
CHRM2 4 (1%) 265 0.343
(1.00) 		0.345
(1.00) 		0.618
(1.00) 		0.576
(1.00) 		0.114
(1.00) 		0.132
(1.00)
DCST2 4 (1%) 265 0.816
(1.00) 		0.412
(1.00) 		0.618
(1.00) 		0.929
(1.00) 		1
(1.00) 		0.632
(1.00)
PRG4 5 (2%) 264 0.77
(1.00) 		0.815
(1.00) 		1
(1.00) 		0.776
(1.00) 		0.171
(1.00) 		1
(1.00)
KDR 9 (3%) 260 0.376
(1.00) 		0.241
(1.00) 		0.498
(1.00) 		0.465
(1.00) 		0.281
(1.00) 		0.19
(1.00)
NOX3 5 (2%) 264 0.832
(1.00) 		0.851
(1.00) 		0.658
(1.00) 		0.73
(1.00) 		0.171
(1.00) 		0.0685
(1.00)
DYNC1I1 7 (3%) 262 0.953
(1.00) 		0.694
(1.00) 		0.0528
(1.00) 		0.634
(1.00) 		0.692
(1.00) 		0.703
(1.00)
PPP1R3A 7 (3%) 262 0.662
(1.00) 		0.771
(1.00) 		0.252
(1.00) 		0.757
(1.00) 		1
(1.00) 		0.703
(1.00)
'IDH1 MUTATION STATUS' versus 'AGE'

P value = 2.36e-05 (t-test), Q value = 0.045

Table S1.  Gene #1: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 269 60.6 (13.2)
IDH1 MUTATED 15 41.1 (13.1)
IDH1 WILD-TYPE 254 61.8 (12.3)

Figure S1.  Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'PUF60 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S2.  Gene #13: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
PUF60 MUTATED 4 80.0 (0.0)
PUF60 WILD-TYPE 204 75.4 (15.4)

Figure S2.  Get High-res Image Gene #13: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF704 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S3.  Gene #32: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ZNF704 MUTATED 3 80.0 (0.0)
ZNF704 WILD-TYPE 205 75.4 (15.4)

Figure S3.  Get High-res Image Gene #32: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF784 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S4.  Gene #34: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ZNF784 MUTATED 3 80.0 (0.0)
ZNF784 WILD-TYPE 205 75.4 (15.4)

Figure S4.  Get High-res Image Gene #34: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GUF1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S5.  Gene #46: 'GUF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
GUF1 MUTATED 3 80.0 (0.0)
GUF1 WILD-TYPE 205 75.4 (15.4)

Figure S5.  Get High-res Image Gene #46: 'GUF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FOXF1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S6.  Gene #53: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
FOXF1 MUTATED 3 80.0 (0.0)
FOXF1 WILD-TYPE 205 75.4 (15.4)

Figure S6.  Get High-res Image Gene #53: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'RBM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S7.  Gene #58: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
RBM3 MUTATED 3 80.0 (0.0)
RBM3 WILD-TYPE 205 75.4 (15.4)

Figure S7.  Get High-res Image Gene #58: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C1ORF187 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S8.  Gene #60: 'C1ORF187 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
C1ORF187 MUTATED 3 80.0 (0.0)
C1ORF187 WILD-TYPE 205 75.4 (15.4)

Figure S8.  Get High-res Image Gene #60: 'C1ORF187 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'EIF4A3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S9.  Gene #62: 'EIF4A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
EIF4A3 MUTATED 3 80.0 (0.0)
EIF4A3 WILD-TYPE 205 75.4 (15.4)

Figure S9.  Get High-res Image Gene #62: 'EIF4A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PRKRIP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S10.  Gene #66: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
PRKRIP1 MUTATED 3 80.0 (0.0)
PRKRIP1 WILD-TYPE 205 75.4 (15.4)

Figure S10.  Get High-res Image Gene #66: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OR5W2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S11.  Gene #86: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
OR5W2 MUTATED 5 80.0 (0.0)
OR5W2 WILD-TYPE 203 75.4 (15.5)

Figure S11.  Get High-res Image Gene #86: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C21ORF58 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S12.  Gene #95: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
C21ORF58 MUTATED 3 80.0 (0.0)
C21ORF58 WILD-TYPE 205 75.4 (15.4)

Figure S12.  Get High-res Image Gene #95: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHEK1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S13.  Gene #110: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CHEK1 MUTATED 3 80.0 (0.0)
CHEK1 WILD-TYPE 205 75.4 (15.4)

Figure S13.  Get High-res Image Gene #110: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SLC4A11 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S14.  Gene #134: 'SLC4A11 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
SLC4A11 MUTATED 3 80.0 (0.0)
SLC4A11 WILD-TYPE 205 75.4 (15.4)

Figure S14.  Get High-res Image Gene #134: 'SLC4A11 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JHDM1D MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S15.  Gene #136: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
JHDM1D MUTATED 3 80.0 (0.0)
JHDM1D WILD-TYPE 205 75.4 (15.4)

Figure S15.  Get High-res Image Gene #136: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ARID3B MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S16.  Gene #155: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ARID3B MUTATED 3 80.0 (0.0)
ARID3B WILD-TYPE 205 75.4 (15.4)

Figure S16.  Get High-res Image Gene #155: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'KRT13 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S17.  Gene #160: 'KRT13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
KRT13 MUTATED 3 80.0 (0.0)
KRT13 WILD-TYPE 205 75.4 (15.4)

Figure S17.  Get High-res Image Gene #160: 'KRT13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CDKN2C MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S18.  Gene #168: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CDKN2C MUTATED 3 80.0 (0.0)
CDKN2C WILD-TYPE 205 75.4 (15.4)

Figure S18.  Get High-res Image Gene #168: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'DSCAM MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.01e-05 (t-test), Q value = 0.057

Table S19.  Gene #170: 'DSCAM MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
DSCAM MUTATED 7 80.0 (0.0)
DSCAM WILD-TYPE 201 75.3 (15.5)

Figure S19.  Get High-res Image Gene #170: 'DSCAM MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MTMR7 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S20.  Gene #176: 'MTMR7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
MTMR7 MUTATED 3 80.0 (0.0)
MTMR7 WILD-TYPE 205 75.4 (15.4)

Figure S20.  Get High-res Image Gene #176: 'MTMR7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CXCL6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S21.  Gene #188: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CXCL6 MUTATED 3 80.0 (0.0)
CXCL6 WILD-TYPE 205 75.4 (15.4)

Figure S21.  Get High-res Image Gene #188: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'RAG1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S22.  Gene #194: 'RAG1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
RAG1 MUTATED 3 80.0 (0.0)
RAG1 WILD-TYPE 205 75.4 (15.4)

Figure S22.  Get High-res Image Gene #194: 'RAG1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LMO1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S23.  Gene #199: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
LMO1 MUTATED 3 80.0 (0.0)
LMO1 WILD-TYPE 205 75.4 (15.4)

Figure S23.  Get High-res Image Gene #199: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LEFTY1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S24.  Gene #206: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
LEFTY1 MUTATED 3 80.0 (0.0)
LEFTY1 WILD-TYPE 205 75.4 (15.4)

Figure S24.  Get High-res Image Gene #206: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'NFKBIL2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S25.  Gene #212: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
NFKBIL2 MUTATED 4 80.0 (0.0)
NFKBIL2 WILD-TYPE 204 75.4 (15.4)

Figure S25.  Get High-res Image Gene #212: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GJB1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S26.  Gene #218: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
GJB1 MUTATED 3 80.0 (0.0)
GJB1 WILD-TYPE 205 75.4 (15.4)

Figure S26.  Get High-res Image Gene #218: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OPRM1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S27.  Gene #219: 'OPRM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
OPRM1 MUTATED 3 80.0 (0.0)
OPRM1 WILD-TYPE 205 75.4 (15.4)

Figure S27.  Get High-res Image Gene #219: 'OPRM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CCDC105 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S28.  Gene #242: 'CCDC105 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CCDC105 MUTATED 4 80.0 (0.0)
CCDC105 WILD-TYPE 204 75.4 (15.4)

Figure S28.  Get High-res Image Gene #242: 'CCDC105 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MAGEC2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S29.  Gene #252: 'MAGEC2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
MAGEC2 MUTATED 5 80.0 (0.0)
MAGEC2 WILD-TYPE 203 75.4 (15.5)

Figure S29.  Get High-res Image Gene #252: 'MAGEC2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHP2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S30.  Gene #253: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CHP2 MUTATED 3 80.0 (0.0)
CHP2 WILD-TYPE 205 75.4 (15.4)

Figure S30.  Get High-res Image Gene #253: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OR5P2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S31.  Gene #260: 'OR5P2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
OR5P2 MUTATED 3 80.0 (0.0)
OR5P2 WILD-TYPE 205 75.4 (15.4)

Figure S31.  Get High-res Image Gene #260: 'OR5P2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TGM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S32.  Gene #267: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
TGM3 MUTATED 5 80.0 (0.0)
TGM3 WILD-TYPE 203 75.4 (15.5)

Figure S32.  Get High-res Image Gene #267: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JAG2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S33.  Gene #268: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
JAG2 MUTATED 3 80.0 (0.0)
JAG2 WILD-TYPE 205 75.4 (15.4)

Figure S33.  Get High-res Image Gene #268: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SPAM1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.01e-05 (t-test), Q value = 0.058

Table S34.  Gene #275: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
SPAM1 MUTATED 6 80.0 (0.0)
SPAM1 WILD-TYPE 202 75.3 (15.5)

Figure S34.  Get High-res Image Gene #275: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FGG MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S35.  Gene #287: 'FGG MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
FGG MUTATED 3 80.0 (0.0)
FGG WILD-TYPE 205 75.4 (15.4)

Figure S35.  Get High-res Image Gene #287: 'FGG MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'DPEP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S36.  Gene #288: 'DPEP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
DPEP1 MUTATED 3 80.0 (0.0)
DPEP1 WILD-TYPE 205 75.4 (15.4)

Figure S36.  Get High-res Image Gene #288: 'DPEP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SIPA1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S37.  Gene #303: 'SIPA1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
SIPA1 MUTATED 3 80.0 (0.0)
SIPA1 WILD-TYPE 205 75.4 (15.4)

Figure S37.  Get High-res Image Gene #303: 'SIPA1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CCDC114 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S38.  Gene #312: 'CCDC114 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CCDC114 MUTATED 5 80.0 (0.0)
CCDC114 WILD-TYPE 203 75.4 (15.5)

Figure S38.  Get High-res Image Gene #312: 'CCDC114 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TLR6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S39.  Gene #314: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
TLR6 MUTATED 3 80.0 (0.0)
TLR6 WILD-TYPE 205 75.4 (15.4)

Figure S39.  Get High-res Image Gene #314: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MSLNL MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.058

Table S40.  Gene #315: 'MSLNL MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
MSLNL MUTATED 4 80.0 (0.0)
MSLNL WILD-TYPE 204 75.4 (15.4)

Figure S40.  Get High-res Image Gene #315: 'MSLNL MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CTDSP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.058

Table S41.  Gene #321: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CTDSP1 MUTATED 3 80.0 (0.0)
CTDSP1 WILD-TYPE 205 75.4 (15.4)

Figure S41.  Get High-res Image Gene #321: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

Methods & Data
Input

  • Mutation data file = GBM.mutsig.cluster.txt

  • Clinical data file = GBM.clin.merged.picked.txt

  • Number of patients = 269

  • Number of significantly mutated genes = 325

  • Number of selected clinical features = 6

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
Made with Nozzle