rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	GUSB(3), RPE(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), XYLB(4)	9832004	43	32	42	16	12	6	11	10	4	0	0.00127	0.322
2	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(4), NR0B2(3), NR1H3(1), NR1H4(3), RXRA(3)	2161711	14	15	15	3	3	2	4	3	2	0	0.00198	0.322
3	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	79	ANPEP(3), CD14(2), CD19(2), CD1B(1), CD1D(2), CD1E(1), CD22(5), CD33(3), CD34(2), CD36(2), CD38(2), CD3E(1), CD3G(1), CD44(4), CD5(2), CD55(2), CD7(2), CD8A(1), CD8B(1), CD9(2), CR1(5), CR2(6), CSF1R(3), CSF3R(2), DNTT(2), EPO(1), EPOR(1), FLT3(7), FLT3LG(1), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL1R1(2), IL2RA(3), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), ITGA1(1), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGAM(8), ITGB3(1), KIT(3), KITLG(2), MS4A1(2), TFRC(2), THPO(1), TPO(4)	31351365	137	76	135	51	54	23	28	20	12	0	0.00200	0.322
4	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), COMT(2), DBH(6), DDC(1), FAH(1), GOT1(1), HPD(1), MAOB(1), PNMT(1), TAT(3), TPO(4), TYR(5)	12332970	66	42	65	14	35	9	9	13	0	0	0.00209	0.322
5	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C1(3), AKR1C4(2), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1B1(4), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP2S1(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHDH(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3)	21984496	98	57	98	32	38	8	24	25	3	0	0.00431	0.507
6	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(1), F13B(2), F2(1), F5(9), F7(1), F8(8), FGA(3), FGB(1), FGG(4), LPA(6), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1), SERPINF2(1), VWF(10)	13638969	54	40	54	22	19	9	11	5	10	0	0.00529	0.507
7	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	129	ACTB(1), CHAD(1), COL11A1(8), COL11A2(9), COL17A1(3), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DES(3), DSC1(5), DSC2(2), DSC3(2), DSG1(4), DSG2(1), DSG3(8), DSG4(10), FN1(3), GJA1(1), GJA10(1), GJA8(1), GJA9(1), GJB3(2), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJC2(1), GJC3(1), INA(2), ITGA6(2), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT14(3), KRT15(1), KRT16(4), KRT17(3), KRT18(3), KRT19(5), KRT2(3), KRT20(1), KRT23(8), KRT24(1), KRT25(3), KRT28(3), KRT3(1), KRT31(3), KRT32(2), KRT33A(3), KRT33B(2), KRT34(3), KRT36(4), KRT37(2), KRT38(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(3), KRT72(1), KRT73(1), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(1), KRT82(1), KRT83(2), KRT84(2), KRT85(2), KRT9(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), LMNB1(1), LMNB2(3), NES(3), RELN(20), SPP1(1), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VIM(1), VWF(10)	91828164	404	152	402	167	153	79	71	45	55	1	0.00576	0.507
8	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(4), HDC(3), PNMT(1), TPH1(3)	2333567	17	13	17	6	10	4	2	1	0	0	0.00660	0.509
9	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(1), GZMB(3), HLA-A(1), ITGAL(4), ITGB2(5), PRF1(3)	3417489	20	15	20	14	6	1	4	1	8	0	0.00745	0.510
10	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CX3CR1(2), CXCR3(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GRPR(1), LHCGR(1), MC2R(1), MC3R(6), MC4R(3), MC5R(2), NPY5R(4), NTSR1(2), OPRK1(1), OPRL1(2), OXTR(2), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR1(1), TACR3(4), TRHR(2), TSHR(1)	19529660	94	54	94	38	39	19	18	14	4	0	0.00966	0.595
11	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(3), CD5(2), CD7(2), IFNB1(1), IFNG(1), IL12B(1), IL4(1), ITGAX(7), TLR2(4), TLR4(1), TLR7(5), TLR9(2)	7416008	33	24	33	13	13	6	9	3	2	0	0.0112	0.629
12	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPX1(2), PRKCE(1)	2387423	14	11	13	9	2	2	4	5	1	0	0.0139	0.714
13	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), ETNK1(1), GNPAT(4), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH2(2), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB2(5), PLCG1(3), PLCG2(11), PPAP2C(1)	19614435	85	52	83	23	35	10	12	16	11	1	0.0170	0.759
14	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(5), F2(1), FGA(3), FGB(1), FGG(4), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1)	5404654	22	20	22	8	9	5	4	2	2	0	0.0173	0.759
15	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	293806	3	3	3	1	2	1	0	0	0	0	0.0196	0.759
16	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CANX(4), CD8A(1), CD8B(1), CIITA(7), CTSS(2), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), HSP90AA1(1), HSP90AB1(2), HSPA5(2), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), LGMN(1), NFYB(1), NFYC(3), PDIA3(1), PSME1(1), PSME2(1), TAP1(4), TAP2(2)	18077249	71	47	70	26	16	11	17	12	15	0	0.0197	0.759
17	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	157	ADORA1(2), ADORA2B(1), ADORA3(1), ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCBP2(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CHML(2), CHRM2(4), CHRM3(3), CMKLR1(1), CNR1(2), CNR2(3), CX3CR1(2), CXCR3(2), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GPR17(1), GPR174(1), GPR27(3), GPR3(1), GPR37(3), GPR4(1), GPR50(3), GPR6(5), GPR83(4), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LHCGR(1), MC3R(6), MC4R(3), MC5R(2), MLNR(1), NMUR1(2), NMUR2(5), NPY5R(4), NTSR1(2), OPN1SW(2), OPRK1(1), OPRL1(2), OR1F1(2), OR1Q1(1), OR2H1(4), OR7A5(1), OR7C1(1), OXTR(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY6(2), PPYR1(2), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RHO(1), RRH(1), SSTR2(1), SSTR3(2), SSTR4(4), TRHR(2)	46347181	215	102	213	84	95	27	38	40	15	0	0.0209	0.759
18	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(5), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPHN(1), NSF(1), SRC(2), UBQLN1(2)	3977986	22	16	21	8	6	3	6	5	2	0	0.0249	0.780
19	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGT(3), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(5), REN(2)	3816834	27	16	27	9	11	5	5	3	3	0	0.0255	0.780
20	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), CHAT(3), COMT(2), DBH(6), DDC(1), GAD1(4), GAD2(3), HDC(3), PAH(1), PNMT(1), TPH1(3)	5608230	28	21	28	9	13	5	3	7	0	0	0.0262	0.780
21	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	2753369	12	12	12	5	7	2	1	1	1	0	0.0271	0.780
22	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), NFYC(3), SP1(6), SP3(1)	1979947	11	9	11	3	2	1	2	3	3	0	0.0304	0.780
23	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(1), TAT(3), TYR(5)	1908974	10	9	10	1	1	3	2	4	0	0	0.0317	0.780
24	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), EPO(1), FLT3(7), IL6(2), KITLG(2), TGFB1(1), TGFB2(1)	3311320	15	13	15	1	2	3	4	2	4	0	0.0326	0.780
25	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	AKT1(1), ASAH1(1), CREB3(1), CREB5(1), CREBBP(8), DAG1(2), EGR1(2), EGR2(3), EGR3(4), ELK1(1), GNAQ(1), MAP1B(9), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NTRK1(4), OPN1LW(3), PIK3CD(2), PTPN11(6), RPS6KA3(5), SRC(2), TERF2IP(3)	16881445	78	46	78	19	21	13	21	17	6	0	0.0335	0.780
26	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ABP1(9), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), SDS(4), UPB1(1)	11727333	58	33	58	12	19	13	10	11	5	0	0.0345	0.780
27	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	21	COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), F10(1), F2(1), F5(9), F8(8), FGA(3), FGB(1), FGG(4), KLKB1(1), PROC(2), SERPINC1(2), SERPING1(5)	17546850	66	42	64	18	18	16	13	10	9	0	0.0346	0.780
28	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(1), AKT1(1), BDKRB2(3), CALM1(1), CAV1(1), FLT1(2), FLT4(3), KDR(10), NOS3(5), PDE2A(3), PDE3A(1), PDE3B(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG2(5), SLC7A1(2), SYT1(1), TNNI1(2)	12178594	48	34	48	16	17	7	4	12	8	0	0.0360	0.780
29	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	39	ALAS1(2), ALAS2(1), BLVRA(1), BLVRB(1), COX10(1), COX15(1), CP(4), CPOX(1), EARS2(2), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UROD(1), UROS(1)	15734582	66	40	65	21	16	6	15	20	9	0	0.0370	0.780
30	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1)	2311758	13	9	13	2	8	0	3	2	0	0	0.0380	0.780
31	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA1(1), GALNS(1), GBA(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NAGLU(1), NEU1(1), NEU2(4), NEU4(4), SPAM1(6)	13554921	52	37	50	16	19	3	10	9	11	0	0.0418	0.818
32	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	236	ACVR1(3), ACVR2B(1), AMHR2(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CCL13(1), CCL15(1), CCL19(1), CCL2(2), CCL20(1), CCL22(1), CCL24(1), CCL26(1), CCL3(1), CCL5(1), CCL7(1), CCR1(2), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CD70(1), CLCF1(1), CNTF(1), CSF1R(3), CSF2RB(4), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL13(1), CXCR3(2), CXCR6(1), EDA(3), EGF(3), EPO(1), EPOR(1), FLT1(2), FLT3(7), FLT3LG(1), FLT4(3), GDF5(2), GH1(1), GH2(2), GHR(3), HGF(4), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL17RB(1), IL18R1(1), IL18RAP(4), IL1R1(2), IL1RAP(2), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), INHBA(3), INHBB(2), INHBE(1), KDR(10), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(1), MET(5), MPL(2), NGFR(1), OSM(1), OSMR(2), PDGFC(3), PDGFRB(5), PPBP(2), PRL(3), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF10A(2), TNFRSF11A(3), TNFRSF13B(2), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(3), TNFSF10(5), TNFSF13B(2), TNFSF14(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFC(2), XCL1(2), XCL2(2), XCR1(1)	65747578	264	111	264	80	93	37	58	44	32	0	0.0444	0.818
33	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1), SELP(2)	6700687	33	21	32	17	13	2	7	6	5	0	0.0448	0.818
34	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F5(9), F7(1), FGA(3), FGB(1), FGG(4), PROC(2), SERPINC1(2)	6457793	24	19	24	9	7	5	6	1	5	0	0.0452	0.818
35	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(5), BDKRB1(1), BDKRB2(3), C1QB(1), C1QC(1), C1R(1), C1S(1), C2(2), C3(8), C3AR1(1), C5(1), C5AR1(1), C6(3), C7(6), C8A(3), C8B(5), C9(1), CD55(2), CFB(1), CFH(3), CFI(1), CPB2(1), CR1(5), CR2(6), F10(1), F13A1(5), F13B(2), F2(1), F5(9), F7(1), F8(8), FGA(3), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(2), MBL2(1), PLAU(2), PLAUR(1), PLG(2), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(5), THBD(3), VWF(10)	35360465	140	73	137	68	46	22	33	19	19	1	0.0470	0.818
36	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	69	CALM1(1), CDS1(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(6), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), OCRL(1), PI4KA(1), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PRKCA(3), PRKCG(1), SYNJ1(1), SYNJ2(7)	46351323	183	92	181	48	68	29	33	25	27	1	0.0478	0.818
37	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(2), LRP8(2), RELN(20), VLDLR(2)	5680593	27	18	27	18	10	8	1	3	5	0	0.0495	0.824
38	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ABP1(9), AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), DAO(3), GAMT(1), GATM(2), GOT1(1), MAOB(1), NOS1(9), NOS3(5), OAT(1), ODC1(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1)	17269425	74	44	73	19	28	17	11	17	1	0	0.0602	0.976
39	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), KERA(2), LUM(3)	1446169	7	7	6	4	2	2	1	0	2	0	0.0619	0.978
40	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD34(2), CD3E(1), CD3G(1), CD58(1), CD8A(1), IL6(2), KITLG(2)	2148473	10	9	10	2	4	0	3	1	2	0	0.0636	0.979
41	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1)	4433802	24	15	23	13	8	2	7	2	5	0	0.0679	1.000
42	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(4), JAK3(4), MAPK1(3), MAPK3(2), STAT3(2), TYK2(3)	4692033	21	16	19	3	9	3	3	5	1	0	0.0711	1.000
43	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(3), CTH(1), GOT1(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MPST(1), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(1), SULT4A1(1)	5047540	24	16	24	4	3	6	7	4	4	0	0.0720	1.000
44	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1)	4933029	22	16	21	14	7	2	6	4	2	1	0.0737	1.000
45	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	4	CD28(1), CD3E(1), CD3G(1)	655647	3	3	3	1	1	0	1	0	1	0	0.0791	1.000
46	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(1), AKT2(1), AKT3(1), BLNK(2), BTK(1), CARD11(6), CD19(2), CD22(5), CD72(2), CHUK(4), CR2(6), FOS(1), GSK3B(1), IFITM1(1), IKBKB(2), INPP5D(6), KRAS(1), LILRB3(1), LYN(1), MALT1(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(2), SYK(2), VAV1(6), VAV2(3), VAV3(2)	27775410	121	64	119	45	46	15	24	22	14	0	0.0795	1.000
47	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(9), AOC2(2), AOC3(2), CES1(2)	2419051	15	10	15	1	8	3	1	3	0	0	0.0804	1.000
48	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	CALCR(6), CALCRL(2), CRHR1(2), ELTD1(5), EMR1(4), EMR2(4), GHRHR(3), GIPR(1), GLP1R(1), GLP2R(1), GPR64(2), LPHN2(4), LPHN3(2), SCTR(2), VIPR2(2)	9586511	41	26	41	16	14	5	8	8	6	0	0.0840	1.000
49	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(1), AKT2(1), AKT3(1), KDR(10), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NOS3(5), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), SH2D2A(2), SPHK1(1), SRC(2), VEGFA(2)	26123137	110	59	110	38	42	15	14	23	15	1	0.0868	1.000
50	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), IL6(2), LDLR(4)	2160204	8	8	8	3	1	1	3	2	1	0	0.0984	1.000
51	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MAX(2), SP1(6), SP3(1), WT1(3)	2504554	13	10	13	1	4	2	2	1	4	0	0.102	1.000
52	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(2), ACADS(4), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), SDS(4)	10403076	48	28	49	14	13	12	7	9	7	0	0.102	1.000
53	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), LPO(1), MPO(3), PRDX2(2), TPO(4), TYR(5)	3807130	21	14	21	8	11	1	2	4	3	0	0.102	1.000
54	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(1), CADM1(2), CADM3(1), CD22(5), CD226(2), CD274(1), CD276(3), CD28(1), CD34(2), CD58(1), CD6(2), CD8A(1), CD8B(1), CDH1(3), CDH15(3), CDH3(1), CDH4(3), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CNTN1(5), CNTN2(4), CNTNAP1(3), ESAM(1), F11R(1), GLG1(4), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), ICAM3(1), ICOSLG(1), ITGA4(7), ITGA6(2), ITGA8(7), ITGA9(1), ITGAL(4), ITGAM(8), ITGAV(1), ITGB2(5), ITGB7(2), ITGB8(3), JAM2(1), JAM3(1), L1CAM(7), MAG(5), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(5), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(3), NRXN3(3), OCLN(1), PDCD1(1), PECAM1(2), PTPRC(4), PTPRF(4), PTPRM(3), PVR(2), PVRL1(2), PVRL2(1), SDC1(1), SDC2(2), SDC4(1), SELE(1), SELP(2), SELPLG(2), SIGLEC1(1), VCAN(7)	57518880	209	106	209	97	81	29	35	32	31	1	0.103	1.000
55	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(8), DFFA(1), DFFB(3), GZMA(1), GZMB(3), PRF1(3)	4170990	21	15	21	5	4	3	6	4	4	0	0.105	1.000
56	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), RPS6KB1(1), STAT6(3)	5883058	23	18	22	6	8	3	3	7	2	0	0.110	1.000
57	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(3), CD36(2), CD44(4), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), DAG1(2), FN1(3), FNDC1(1), FNDC3A(2), GP9(1), HMMR(1), HSPG2(16), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), RELN(20), SDC1(1), SDC2(2), SDC4(1), SPP1(1), SV2B(1), SV2C(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VWF(10)	83707935	323	133	323	121	118	67	51	41	45	1	0.113	1.000
58	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(1)	1952432	8	8	6	1	6	0	1	1	0	0	0.117	1.000
59	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(4), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2)	12777875	58	33	54	16	28	6	10	10	4	0	0.122	1.000
60	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	5	CCL2(2), MST1R(6)	2032362	8	8	8	5	4	0	0	3	1	0	0.123	1.000
61	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	468602	2	2	2	1	0	0	1	0	1	0	0.123	1.000
62	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	ALOX15(2), ALOX5(1), CBR1(1), CBR3(2), CYP4F2(5), CYP4F3(5), EPX(6), GGT1(2), LPO(1), LTA4H(1), MPO(3), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PRDX2(2), PTGIS(1), PTGS1(2), TBXAS1(3), TPO(4)	10927491	51	31	51	18	28	5	6	5	6	1	0.126	1.000
63	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(2), CDKN2A(3), FLOT1(2), GAB1(1), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), NR0B2(3), PLCG2(11), PREX1(9), PTPRC(4), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SYK(2), TEC(5), VAV1(6)	20753223	91	48	91	29	32	17	18	12	12	0	0.130	1.000
64	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	49	ADORA3(1), CCKBR(2), CCR3(2), CELSR1(10), CELSR2(9), CELSR3(8), CHRM2(4), CHRM3(3), CXCR3(2), EDNRA(1), EMR2(4), EMR3(2), FSHR(1), GHRHR(3), GPR116(9), GPR132(3), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR56(2), GPR61(2), GPR84(1), GPR88(1), GRM1(1), GRPR(1), HRH4(1), LGR6(3), LPHN2(4), LPHN3(2), LTB4R2(2), NTSR1(2), OR2M4(2), OR8G2(1), P2RY13(3), PTGFR(2), SMO(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(1)	24791623	110	57	110	45	40	15	21	20	14	0	0.131	1.000
65	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), ITK(3), PTPN11(6)	3682662	16	12	16	6	2	3	4	6	1	0	0.131	1.000
66	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ABP1(9), ACADM(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), UPB1(1)	10880045	46	28	46	9	17	7	8	11	3	0	0.135	1.000
67	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	10	CREBBP(8), DAXX(4), PAX3(3), PML(2), SIRT1(2), SP100(3), TNFRSF1A(2), TNFRSF1B(2)	6197133	26	18	26	8	6	5	7	4	4	0	0.136	1.000
68	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(2), ENPP3(1), NADSYN1(4), NMNAT2(1), NNMT(1), QPRT(3)	5902823	19	17	16	2	8	2	2	6	1	0	0.137	1.000
69	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), NOS1(9), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SYT1(1)	9871541	44	29	42	19	20	3	8	11	2	0	0.137	1.000
70	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR109B(3), GPR161(2), GPR18(1), GPR34(1), GPR45(2), GPR65(1), GPR68(2), GPR81(2)	3922283	16	12	16	5	6	2	2	4	2	0	0.138	1.000
71	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(2), ARSD(1), ARSE(1), CARM1(1), CYP11B2(4), CYP19A1(3), HSD11B1(2), HSD17B3(1), HSD17B7(1), HSD17B8(1), HSD3B2(2), LCMT1(1), PRMT7(2), PRMT8(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3)	18808187	61	42	60	32	19	8	17	13	4	0	0.138	1.000
72	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(2), AGT(3), AGTR1(2), AGTR2(1), ANPEP(3), CTSA(2), CTSG(4), ENPEP(9), LNPEP(2), NLN(1), REN(2), THOP1(1)	8431879	39	22	39	13	17	5	8	3	6	0	0.142	1.000
73	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(3)	1070053	4	4	4	0	1	2	1	0	0	0	0.142	1.000
74	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	226	ADORA1(2), ADORA2B(1), ADORA3(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), C5AR1(1), CALCR(6), CALCRL(2), CCKAR(3), CCKBR(2), CGA(1), CHRM2(4), CHRM3(3), CNR1(2), CNR2(3), CRHR1(2), CTSG(4), CYSLTR1(1), CYSLTR2(1), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR1(1), GABBR2(6), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRB1(3), GABRB3(2), GABRD(2), GABRG1(2), GABRG2(6), GABRP(4), GABRQ(2), GABRR2(1), GALR1(3), GALR2(1), GH1(1), GH2(2), GHR(3), GHRHR(3), GHSR(4), GIPR(1), GLP1R(1), GLP2R(1), GLRA2(1), GLRA3(3), GLRB(1), GPR156(3), GPR50(3), GPR83(4), GRIA1(4), GRIA3(5), GRIA4(2), GRID1(3), GRID2(1), GRIK1(1), GRIK2(2), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRIN3B(1), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM6(6), GRM7(3), GRM8(8), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HRH4(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R2(2), MC2R(1), MC3R(6), MC4R(3), MC5R(2), MCHR1(2), MCHR2(3), MLNR(1), NMUR1(2), NMUR2(5), NPBWR1(2), NPFFR1(2), NPFFR2(2), NPY5R(4), NR3C1(1), NTSR1(2), OPRK1(1), OPRL1(2), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY4(2), P2RY6(2), PARD3(2), PPYR1(2), PRL(3), PRSS1(1), PTAFR(2), PTGDR(1), PTGER2(2), PTGER3(2), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(3), RXFP2(1), SCTR(2), SSTR2(1), SSTR3(2), SSTR4(4), SSTR5(2), TAAR2(1), TAAR5(1), TACR1(1), TACR3(4), THRA(1), TRHR(2), TSHB(1), TSHR(1), TSPO(1), UTS2R(1), VIPR2(2)	83748399	379	142	378	165	169	49	62	67	32	0	0.144	1.000
75	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(2), ABCB4(8), ABCC1(3), ABCC3(5), GSTP1(1)	5751848	23	18	23	12	9	4	2	4	4	0	0.144	1.000
76	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(4), ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(4), CACNA1B(7), GNAS(3), GNAT3(3), GNB1(1), GNB3(1), GRM4(5), ITPR3(11), KCNB1(3), PDE1A(1), PLCB2(5), PRKACG(1), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R14(2), TAS2R16(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R41(3), TAS2R42(1), TAS2R60(1), TAS2R8(1), TRPM5(1)	21727627	89	53	89	45	39	11	16	14	9	0	0.150	1.000
77	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(1), AKT2(1), AKT3(1), ANKRD6(3), APC(7), AXIN1(2), AXIN2(1), DACT1(5), DKK1(1), DKK2(3), FSTL1(2), GSK3B(1), LRP1(15), MVP(2), NKD2(2), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2)	15524662	58	37	52	11	18	3	15	14	8	0	0.152	1.000
78	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(3), STAT1(1), STAT2(5), TYK2(3)	4326909	14	12	14	3	4	2	5	1	2	0	0.154	1.000
79	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	1940571	9	7	9	2	0	4	1	1	3	0	0.158	1.000
80	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), PRDX2(2), TAT(3), TPO(4)	8803849	43	26	44	10	23	5	4	8	3	0	0.158	1.000
81	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	3532572	12	11	12	7	6	3	2	0	1	0	0.166	1.000
82	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2)	3532572	12	11	12	7	6	3	2	0	1	0	0.166	1.000
83	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), MAPK1(3), MAPK3(2), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(4), PLCG1(3)	5981265	19	18	19	10	5	5	4	5	0	0	0.166	1.000
84	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL2RA(3), IL4(1), IL4R(6)	5130651	28	15	28	4	12	5	4	5	2	0	0.167	1.000
85	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA(1), LPO(1), MPO(3), TPO(4)	3329226	15	12	15	7	11	0	0	1	3	0	0.172	1.000
86	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(1), C6(3), C7(6), IL6(2), ITGA4(7), ITGAL(4), ITGB2(5), SELP(2), SELPLG(2)	9840865	40	25	39	26	13	3	7	8	8	1	0.175	1.000
87	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), CHRM2(4), CHRM3(3), DRD1(2), DRD2(1), DRD3(1), DRD5(4), HRH1(1), HRH2(5), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1)	9718968	48	29	48	18	23	5	8	8	4	0	0.176	1.000
88	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(9), FASN(7), MCAT(1), OXSM(3)	5930850	28	17	28	7	11	1	8	5	3	0	0.177	1.000
89	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	21	IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MIOX(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PIK3CG(12), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11)	15943347	64	37	63	19	23	11	15	5	9	1	0.178	1.000
90	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), GK(1), GLA(1), GLB1(1), LCT(8), LIPC(1), LIPG(5), PNLIP(2), PNLIPRP1(2), PPAP2C(1)	18858900	84	44	83	21	34	14	17	12	7	0	0.181	1.000
91	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(1), CD3G(1), CD8A(1), ITGAL(4), ITGB2(5), PTPRC(4)	4298928	17	12	17	12	5	2	3	0	7	0	0.183	1.000
92	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(1), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(4), GOT1(1), NOS1(9), NOS3(5), OAT(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(1), RARS2(1)	13953345	52	33	51	16	20	8	11	12	1	0	0.184	1.000
93	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(4), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(5), NFATC1(3), NFATC2(1), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SYT1(1), VIP(1), VIPR2(2)	10901738	36	28	35	16	7	4	4	12	9	0	0.187	1.000
94	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(1), IL12B(1), IL2(1)	1206627	7	4	7	0	1	2	0	2	2	0	0.189	1.000
95	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(3), EPHB1(10), ITGA1(1), L1CAM(7), LYN(1), RAP1B(2), SELP(2)	6284921	27	17	26	8	11	5	6	3	2	0	0.190	1.000
96	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), PIAS3(4), PTPRU(3), SRC(2), STAT3(2)	6157097	26	19	23	4	12	4	3	5	2	0	0.195	1.000
97	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), NAGLU(1), SPAM1(6)	8100775	32	22	31	10	12	2	6	6	6	0	0.197	1.000
98	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(9), AGXT2(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PISD(3), PLCB2(5), PLCG1(3), PLCG2(11), PSPH(2), SHMT2(1), TARS(2)	16243288	68	37	68	18	29	14	11	8	6	0	0.200	1.000
99	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), ELAVL1(1), FLT1(2), FLT4(3), HIF1A(1), KDR(10), NOS3(5), PLCG1(3), PRKCA(3), PTK2(2), PXN(1), VHL(1)	11874292	41	28	41	12	13	5	6	11	6	0	0.201	1.000
100	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	13	CD3E(1), CD3G(1), CXCR3(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(4), STAT4(1), TYK2(3)	5256848	22	14	21	8	11	1	5	1	4	0	0.202	1.000
101	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NFKB1(1), SP1(6)	5623970	22	16	22	5	4	5	2	5	6	0	0.204	1.000
102	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP5(2), ACP6(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CMBL(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHRS7(1), PON1(4), PON3(2)	6896273	31	19	31	7	12	3	7	8	1	0	0.206	1.000
103	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(2), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CLCA1(3), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(2), CNGB1(5), GNAL(1), GUCA1B(1), GUCA1C(3), PDE1C(4), PRKACG(1), PRKG2(5), PRKX(2)	12240769	45	30	44	22	13	7	11	11	3	0	0.206	1.000
104	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), DHFR(1), FPGS(2)	2450112	11	9	11	4	4	0	4	2	1	0	0.210	1.000
105	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3)	4182675	17	12	16	5	10	2	3	1	1	0	0.212	1.000
106	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3)	4182675	17	12	16	5	10	2	3	1	1	0	0.212	1.000
107	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ITGA4(7), ITGAL(4), ITGB2(5), PECAM1(2), SELE(1)	5304269	23	14	23	13	7	1	4	6	5	0	0.213	1.000
108	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGAT2(2), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), GK(1), GK2(2), GLA(1), GLB1(1), GPAM(2), LCT(8), LIPC(1), LIPG(5), MGLL(2), PNLIP(2), PNLIPRP1(2), PNPLA3(1), PPAP2C(1)	23080983	89	50	88	25	37	11	17	16	8	0	0.218	1.000
109	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(2), HLA-A(1), KLRC1(1), KLRC3(3), MAP2K1(1), MAPK3(2), PAK1(2), PTK2B(1), PTPN6(4), SYK(2), VAV1(6)	5990598	25	15	25	12	7	1	12	2	3	0	0.222	1.000
110	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(8), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SDS(4), SUCLA2(1), SUCLG1(2)	13418593	50	29	50	11	12	13	10	6	9	0	0.223	1.000
111	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1A(1), CDKN1B(3), CDKN2A(3), E2F2(3), MDM2(1)	2835188	11	10	11	7	2	5	0	0	4	0	0.224	1.000
112	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(9), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DDC(1), HAL(2), HARS(3), HDC(3), HNMT(1), MAOB(1), PRPS2(2)	9896289	48	27	49	9	24	9	5	8	2	0	0.224	1.000
113	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), CHST1(2), CHST2(3), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL3(1)	4837895	20	14	20	5	6	6	2	5	1	0	0.226	1.000
114	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), MINPP1(1), MIOX(1), OCRL(1), PI4KA(1), PI4KB(3), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), SYNJ1(1), SYNJ2(7)	27995081	106	58	105	32	40	17	19	13	16	1	0.228	1.000
115	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE1(1), CCNE2(1), CDKN1B(3), CDKN2A(3), E2F2(3)	3378480	12	11	12	8	3	3	1	1	4	0	0.228	1.000
116	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4)	8067047	29	21	28	9	14	1	5	4	5	0	0.229	1.000
117	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD28(1), CD3E(1), CD3G(1), ITGAL(4), ITGB2(5), PTPRC(4)	4160681	16	11	16	12	4	2	3	0	7	0	0.233	1.000
118	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(2)	10143840	39	26	37	13	15	10	4	4	6	0	0.235	1.000
119	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(1), GSS(1), NFKB1(1), NOX1(2), XDH(8)	4061497	15	11	14	5	2	3	7	1	2	0	0.237	1.000
120	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4)	19416741	88	44	88	15	42	14	13	13	6	0	0.246	1.000
121	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4)	19416741	88	44	88	15	42	14	13	13	6	0	0.246	1.000
122	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(5), GABBR1(1), GPRC5A(1), GPRC5C(1), GPRC5D(2), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM7(3), GRM8(8)	7588700	29	21	29	26	14	1	6	4	4	0	0.246	1.000
123	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), COMT(2), DBH(6), DDC(1), ESCO1(2), FAH(1), GOT1(1), HPD(1), LCMT1(1), MAOB(1), MYST3(4), MYST4(4), PNMT(1), PNPLA3(1), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(3), TPO(4), TYR(5), TYRP1(2)	23154003	86	51	85	23	40	11	12	18	5	0	0.246	1.000
124	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	8	EGF(3), MAP2K1(1), MAP3K1(5), MAPK14(1), NCOR2(5), RXRA(3), THRA(1)	5254910	19	15	20	7	4	3	2	5	5	0	0.252	1.000
125	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(1), FOS(1), IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2), STAT3(2)	9560632	34	23	32	6	11	5	6	8	4	0	0.253	1.000
126	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	GUSB(3), RPE(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5)	6320515	18	16	18	11	4	5	3	3	3	0	0.257	1.000
127	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(1), CD244(1), FCER1G(1), FCGR3A(1), GZMB(3), HCST(1), HLA-A(1), HLA-B(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), ITGAL(4), ITGB2(5), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), KLRK1(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MICB(1), NCR1(2), NCR2(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), PAK1(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRF1(3), PRKCA(3), PRKCG(1), PTK2B(1), PTPN11(6), PTPN6(4), SH2D1B(1), SH3BP2(2), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SYK(2), TNFRSF10A(2), TNFSF10(5), ULBP1(1), VAV1(6), VAV2(3), VAV3(2), ZAP70(5)	42313032	161	80	162	77	52	18	37	30	24	0	0.260	1.000
128	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	207423	1	1	1	0	1	0	0	0	0	0	0.272	1.000
129	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(5), TYK2(3)	5024612	16	14	16	4	7	1	5	1	2	0	0.273	1.000
130	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(4), ELK1(1), FOS(1), IKBKB(2), IRAK1(2), LY96(1), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), PPARA(1), TLR10(1), TLR2(4), TLR4(1), TLR6(6), TLR7(5), TLR9(2)	14541644	47	32	46	25	9	13	8	12	5	0	0.279	1.000
131	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), HLA-DRA(1), HLA-DRB1(2)	599954	4	3	4	0	1	2	0	1	0	0	0.280	1.000
132	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C8B(5), C9(1), MASP1(2)	8218368	34	20	33	21	10	5	9	7	2	1	0.285	1.000
133	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	25	CCL3(1), CCR1(2), CCR3(2), CCR4(1), CCR7(2), CD28(1), CXCR3(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL4(1), IL4R(6), TGFB1(1), TGFB2(1)	7153969	34	18	34	6	12	3	8	5	6	0	0.286	1.000
134	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(1), PDE1A(1), PLCB1(3), PLCB2(5), PRL(3), TRH(1), VIP(1)	4434609	18	11	18	5	10	3	2	1	1	1	0.290	1.000
135	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), PTPRC(4), ZAP70(5)	3302814	14	9	14	5	4	4	2	1	3	0	0.290	1.000
136	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(1), AKT2(1), AKT3(1), BTK(1), FCER1A(3), FCER1G(1), GAB2(3), IL4(1), INPP5D(6), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PRKCA(3), PRKCD(5), PRKCE(1), SOS1(1), SOS2(4), SYK(2), VAV1(6), VAV2(3), VAV3(2)	26888762	113	56	113	46	49	16	17	17	13	1	0.290	1.000
137	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), NR3C1(1), RETN(1), RXRA(3)	2319283	7	8	8	4	1	2	0	1	3	0	0.291	1.000
138	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(1), ACTN3(1), ACTN4(4), ARHGAP5(2), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(2), ESAM(1), EZR(3), F11R(1), GNAI2(1), GRLF1(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), ITK(3), JAM2(1), JAM3(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(1), MMP9(2), MSN(1), MYL2(2), MYLPF(1), NCF1(2), NCF4(1), NOX1(2), NOX3(5), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), RAPGEF3(1), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(2), ROCK1(3), ROCK2(4), SIPA1(3), TXK(1), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2)	47453685	182	87	181	80	67	19	43	29	24	0	0.296	1.000
139	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(1)	620625	2	2	2	0	0	0	1	1	0	0	0.297	1.000
140	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(3), BCMO1(2), RDH5(1)	1582419	10	5	10	1	3	5	1	0	1	0	0.297	1.000
141	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), C9orf95(1), CD38(2), ENPP3(1), NADK(3), NADSYN1(4), NMNAT2(1), NNMT(1), NT5C1B(3), NT5C2(2), QPRT(3)	8700021	28	21	25	8	10	2	5	9	2	0	0.298	1.000
142	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	5388913	21	14	21	5	11	1	5	4	0	0	0.300	1.000
143	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1R1(2), IRAK1(2), MAP3K1(5), MAP3K14(2), MAP3K7(2), NFKB1(1), NFKBIA(2), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2)	9716920	29	22	28	14	4	5	6	10	4	0	0.303	1.000
144	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SPTLC1(2), SPTLC2(1), UGCG(1)	9552915	35	23	34	15	12	5	4	4	9	1	0.304	1.000
145	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1)	6877628	27	17	26	20	9	3	7	5	2	1	0.307	1.000
146	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(5), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2)	3035540	12	8	12	4	1	4	4	1	2	0	0.308	1.000
147	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.309	1.000
148	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.309	1.000
149	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6141389	27	16	27	8	9	6	8	1	3	0	0.309	1.000
150	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(1), NAT2(1), XDH(8)	3252534	12	10	12	4	3	2	4	1	2	0	0.310	1.000
151	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	APH1A(3), CREBBP(8), CTBP1(3), CTBP2(4), DLL3(1), DTX1(1), DTX3L(1), DVL2(2), EP300(5), HDAC1(1), HDAC2(3), HES1(1), JAG1(3), JAG2(5), LFNG(1), MAML1(3), MAML2(2), MAML3(1), MFNG(2), NCOR2(5), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMB(1), NUMBL(2), PSEN2(1), RBPJ(1), RBPJL(4), SNW1(1)	25862211	87	52	84	29	27	12	20	15	12	1	0.310	1.000
152	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME3(3), PGK2(3), PKLR(4), RPE(1), TKT(2), TKTL1(2), TKTL2(2)	7845277	34	21	34	8	11	5	7	8	3	0	0.311	1.000
153	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(8), CD3E(1), CD3G(1), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8585976	38	23	38	11	14	8	7	4	5	0	0.313	1.000
154	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(8), CD3E(1), CD3G(1), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8585976	38	23	38	11	14	8	7	4	5	0	0.313	1.000
155	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(5), ESR1(3), MAPK1(3), MAPK3(2), PELP1(2), SRC(2)	5861877	25	14	25	4	6	5	8	4	1	1	0.322	1.000
156	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CD44(4), FCGR3A(1), IL6R(2), TGFB1(1), TGFB2(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(3), TNFSF8(1)	5271297	24	14	24	7	6	4	6	3	5	0	0.323	1.000
157	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1), NTAN1(1), SIRT1(2), SIRT2(2), VNN2(1)	4653069	13	11	13	1	2	2	1	2	6	0	0.327	1.000
158	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), PON1(4)	11601263	49	29	49	17	21	2	14	11	1	0	0.328	1.000
159	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(2), AP2M1(4), BIN1(1), CALM1(1), DNM1(5), EPN1(1), EPS15(1), PICALM(2), PPP3CB(1), SYNJ1(1), SYNJ2(7), SYT1(1)	8612476	33	21	32	7	9	6	8	3	7	0	0.332	1.000
160	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(1), BLVRB(1), CP(4), CPOX(1), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UROD(1), UROS(1)	10330169	38	24	38	16	10	4	6	12	6	0	0.336	1.000
161	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	19	ACY1(1), ALDH18A1(1), ARG2(2), CKB(1), CKM(1), CKMT1B(2), CPS1(6), GAMT(1), GATM(2), OAT(1), ODC1(1), OTC(2)	6636656	21	16	21	5	4	5	4	7	1	0	0.338	1.000
162	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(2), ACOX3(1), FADS2(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3)	3962896	19	12	19	6	7	1	2	4	4	1	0.341	1.000
163	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(2), GOT1(1), PAH(1), TAT(3), YARS(2)	3374325	10	9	10	4	4	2	2	2	0	0	0.345	1.000
164	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(4), GPAM(2), GPD1(2), GPD2(1), LCAT(1), MYST3(4), MYST4(4), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1), PTDSS2(1), SH3GLB1(2)	25960462	89	52	87	26	30	11	15	18	14	1	0.349	1.000
165	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(1), CD3G(1), CXCR3(2), ETV5(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), JAK2(4), MAPK14(1), STAT4(1), TYK2(3)	7214838	26	17	25	11	11	1	7	2	5	0	0.355	1.000
166	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(12), CALM1(1), CAPN2(1), CAPNS1(1), EP300(5), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(3), NFATC2(1), PPP3CB(1), PRKCA(3), SYT1(1)	9559706	34	22	34	10	9	3	8	9	4	1	0.356	1.000
167	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2B(1), ADORA3(1), P2RY1(1), P2RY2(2), P2RY6(2)	2363953	9	8	9	1	3	0	2	2	2	0	0.356	1.000
168	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK2(4), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(3), SOAT1(2)	5522242	22	15	19	4	12	1	4	4	1	0	0.358	1.000
169	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TAL1(1), TALDO1(1), TKT(2)	8108679	38	20	38	7	16	7	3	8	4	0	0.359	1.000
170	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(3), AGTR1(2), AGTR2(1), COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), REN(2)	10340714	39	23	37	11	13	11	6	5	4	0	0.361	1.000
171	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(12), CALM1(1), CAMK1(2), HDAC5(4), IGF1R(2), INSR(5), MAPK14(1), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2), NFATC1(3), NFATC2(1), PPP3CB(1), SYT1(1)	12060348	42	29	42	14	11	8	9	9	5	0	0.362	1.000
172	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SP1(6), SP3(1), SYT1(1)	8245499	26	19	26	11	4	4	4	8	6	0	0.363	1.000
173	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	4899111	23	13	23	5	5	8	4	3	3	0	0.363	1.000
174	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(3), PLCG1(3), PRKCA(3), VAV1(6)	3662901	16	9	16	7	5	4	4	2	0	1	0.364	1.000
175	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(3), GALNT2(4), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), ST3GAL1(2), WBSCR17(7)	5757903	29	15	29	14	15	4	6	1	3	0	0.366	1.000
176	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	13	CD8A(1), EPO(1), IL2(1), IL4(1), IL6(2), IL7(1)	2026590	7	6	7	1	3	1	0	2	1	0	0.367	1.000
177	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), FARSB(1), GOT1(1), PAH(1), TAT(3), YARS(2), YARS2(2)	3538569	11	9	11	2	2	4	3	2	0	0	0.371	1.000
178	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNB1(1), IKBKB(2), IL1R1(2), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(2), IRAK2(3), IRAK3(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), TGFB1(1), TGFB2(1)	11783783	37	26	36	16	5	5	5	13	9	0	0.376	1.000
179	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(2), ARSB(2), ARSD(1), ARSE(1), CYP11B2(4), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B2(2), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5)	10343168	33	23	33	22	10	6	7	6	4	0	0.379	1.000
180	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT1(1), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND2(1), CLCF1(1), CNTF(1), CREBBP(8), CSF2RB(4), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(3), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), IRF9(2), JAK1(3), JAK2(4), JAK3(4), LEPR(1), LIFR(1), MPL(2), OSM(1), OSMR(2), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PRL(3), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(1), SOCS4(2), SOS1(1), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(2), STAM2(2), STAT1(1), STAT2(5), STAT3(2), STAT4(1), STAT5A(2), STAT5B(2), STAT6(3), TPO(4), TYK2(3)	55040248	199	88	196	72	71	28	47	34	18	1	0.380	1.000
181	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(1), AKT2(1), AKT3(1), CAB39(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(1), MAPK1(3), MAPK3(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PRKAA2(1), RICTOR(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TSC1(4), TSC2(2), ULK1(1), ULK2(6), ULK3(1), VEGFA(2), VEGFC(2)	18505523	68	39	68	22	22	12	10	11	13	0	0.381	1.000
182	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(4), APOE(1), CETP(2), HMGCR(1), LCAT(1), LDLR(4), LIPC(1), LRP1(15), SCARB1(1), SOAT1(2)	10040960	32	21	29	9	5	5	12	5	4	1	0.381	1.000
183	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1)	6464244	27	16	27	8	9	6	8	1	3	0	0.386	1.000
184	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	ERBB2(7), ERBB4(1), ETV7(1), FMN2(2), KRAS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(3), PIWIL3(4), PIWIL4(1), SOS1(1), SOS2(4), SPIRE1(3), SPIRE2(4)	18770439	60	39	55	20	15	5	10	16	14	0	0.389	1.000
185	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(5), CACNA1D(9), CACNA1F(10), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CGA(1), ELK1(1), GNA11(2), GNAQ(1), GNAS(3), GNRH1(1), GNRH2(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK9(2), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLD2(1), PRKACG(1), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(1), SOS1(1), SOS2(4), SRC(2)	49572904	202	89	200	63	81	28	34	36	21	2	0.391	1.000
186	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3)	9003646	30	21	29	12	6	3	6	11	4	0	0.391	1.000
187	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(6), LPO(1), MPO(3), MTHFR(3), SHMT2(1), TPO(4)	4632196	18	13	18	9	12	0	2	1	3	0	0.394	1.000
188	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1C1(3), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(7)	12995770	54	29	54	22	27	5	9	3	10	0	0.395	1.000
189	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4), NEU4(4)	6545653	23	15	22	7	11	1	3	4	4	0	0.396	1.000
190	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME2(2), ME3(3), PKLR(4), RPE(1), TKT(2)	6979042	29	18	29	6	10	3	6	8	2	0	0.396	1.000
191	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(3), INSR(5), IRS1(4), JAK2(4), MAP2K1(1), MAPK1(3), MAPK3(2), PLCG1(3), PRKCA(3), PTPN6(4), SLC2A4(3), SOCS1(1), SOS1(1), SRF(2), STAT5A(2), STAT5B(2)	11643369	44	26	43	13	16	7	8	10	3	0	0.400	1.000
192	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4)	14781438	56	32	56	14	17	10	12	10	7	0	0.402	1.000
193	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(9), AGXT2(2), AKR1B10(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PHGDH(1), PIPOX(2), PISD(3), PSPH(2), RDH13(1), SARS2(2), SDS(4), SHMT2(1), TARS(2), TARS2(1)	16579849	62	35	61	15	23	14	12	7	6	0	0.402	1.000
194	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(3), SCAP(5), SREBF1(2), SREBF2(3)	4554029	18	12	18	6	7	2	4	0	5	0	0.402	1.000
195	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSS(1), GSTA1(2), GSTA4(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1)	6880063	26	15	25	6	11	2	6	6	1	0	0.405	1.000
196	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLUD2(4)	1683449	7	5	7	2	3	0	3	0	1	0	0.408	1.000
197	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), CALM1(1), ELK1(1), FCER1A(3), FCER1G(1), FOS(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLA2G4A(4), PLCG1(3), PPP3CB(1), SOS1(1), SYK(2), SYT1(1), VAV1(6)	15627890	46	30	46	23	9	10	8	12	6	1	0.420	1.000
198	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1)	4103160	15	11	15	5	4	1	3	5	2	0	0.420	1.000
199	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CAMKK1(3), CAMKK2(1), SYT1(1)	4626443	15	13	15	6	3	1	2	6	3	0	0.423	1.000
200	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), CHUK(4), ELK1(1), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(1), RALA(1), RALBP1(3), RALGDS(3), RHOA(1)	6100778	19	15	18	5	4	1	3	6	5	0	0.424	1.000
201	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX12B(1), ALOX15(2), ALOX15B(1), ALOX5(1), CBR1(1), CBR3(2), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP4A11(3), CYP4A22(4), CYP4F2(5), CYP4F3(5), EPHX2(2), GGT1(2), GPX1(2), GPX2(1), GPX5(2), LTA4H(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3)	15372562	67	33	66	28	31	6	15	9	5	1	0.425	1.000
202	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(1), AKT2(1), AKT3(1), CCL3(1), CCL5(1), CD14(2), CHUK(4), FOS(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IKBKB(2), IL12B(1), IL6(2), IRAK1(2), IRAK4(2), LBP(2), LY96(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), RIPK1(1), SPP1(1), STAT1(1), TBK1(2), TLR1(2), TLR2(4), TLR4(1), TLR5(4), TLR6(6), TLR7(5), TLR8(3), TLR9(2), TRAF3(3)	33670243	110	59	109	52	29	21	18	27	15	0	0.425	1.000
203	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3)	2740861	9	8	9	4	5	0	0	1	3	0	0.435	1.000
204	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2)	2695597	11	8	12	1	2	3	2	2	2	0	0.438	1.000
205	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(1)	2728774	9	7	9	6	2	1	3	2	1	0	0.440	1.000
206	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1)	2556429	13	10	13	4	7	1	3	1	1	0	0.442	1.000
207	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(1), IFNGR2(1), JAK1(3), JAK2(4), STAT1(1)	3343293	11	8	10	0	6	0	1	2	2	0	0.442	1.000
208	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(2), GAD1(4), GAD2(3), GGT1(2)	2278836	12	6	12	2	4	3	2	3	0	0	0.451	1.000
209	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), ESCO1(2), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(4)	13787304	54	32	55	11	25	7	5	11	6	0	0.451	1.000
210	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	IFNG(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(4), NFKB1(1), NFKBIA(2), TNFRSF1A(2), TNFRSF1B(2), USH1C(1), WT1(3)	6173227	20	14	19	8	7	1	4	5	3	0	0.452	1.000
211	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(2), SYT1(1), TRAF2(2), TRAF3(3), TRAF5(1)	10428430	37	23	37	10	12	2	9	10	4	0	0.455	1.000
212	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), DFFB(3), GZMB(3), TOP2A(1), TOP2B(1)	3551959	9	8	9	2	2	0	2	3	2	0	0.456	1.000
213	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NGFR(1)	3196853	11	8	11	2	4	1	2	3	1	0	0.461	1.000
214	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(6), GLS(3), GOT1(1)	3019519	10	7	10	2	2	2	4	1	1	0	0.469	1.000
215	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2), TOB1(2), TOB2(1)	4320259	22	10	22	3	5	3	4	3	7	0	0.470	1.000
216	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS2(2), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PGM3(2), PKLR(4)	22858971	92	46	92	21	41	12	15	16	8	0	0.470	1.000
217	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT1(1), AKT2(1), AKT3(1), BCL2(3), GSK3B(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), MAP4K1(1), MAPK1(3), MAPK3(2), PIK3CD(2), SOCS1(1), SOS1(1), SOS2(4), STAT6(3)	12602564	41	27	40	11	14	4	9	11	3	0	0.471	1.000
218	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ACADVL(3), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CPT2(1), CYP4A11(3), CYP4A22(4), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1)	19720139	63	40	62	16	23	4	14	12	10	0	0.472	1.000
219	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(9), ACY3(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AMDHD1(3), AOC2(2), AOC3(2), CARM1(1), CNDP1(4), DDC(1), FTCD(3), HAL(2), HARS(3), HARS2(1), HDC(3), HNMT(1), LCMT1(1), MAOB(1), PRMT7(2), PRMT8(1), PRPS2(2), UROC1(2)	15524197	56	36	57	17	29	5	6	14	2	0	0.472	1.000
220	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(1), ALDOC(3), DERA(2), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKT(2), TKTL1(2), TKTL2(2)	9580655	43	22	43	7	18	6	6	8	5	0	0.473	1.000
221	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(2), ACP6(2), ACPT(3), ENPP3(1), LHPP(1), MTMR1(2), MTMR2(3), RFK(1), TYR(5)	6011045	20	12	20	5	4	4	4	6	2	0	0.474	1.000
222	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(1), CCND2(1), CCNE1(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), RBL1(3)	5489046	17	12	17	8	1	4	5	2	5	0	0.485	1.000
223	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(2), ACADS(4), ECHS1(1), HADHA(1)	2142674	8	6	9	2	3	1	2	1	1	0	0.485	1.000
224	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCR3(2), HLA-DRA(1), HLA-DRB1(2), IL4(1), IL5RA(1), IL6(2)	1808654	9	5	9	1	2	3	0	2	2	0	0.488	1.000
225	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(5), AMY2B(1), ENPP3(1), G6PC(2), GAA(3), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), MGAM(7), PGM3(2), PYGB(4), PYGL(1), PYGM(2), SI(3), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UXS1(1)	21856473	66	42	64	30	30	8	12	9	7	0	0.492	1.000
226	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1C(2), AKT1(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(4), CACNG6(1), CACNG7(1), CACNG8(1), CD14(2), CDC25B(1), CHUK(4), DAXX(4), DDIT3(1), DUSP10(1), DUSP14(1), DUSP16(1), DUSP2(2), DUSP4(3), DUSP8(1), DUSP9(1), EGF(3), ELK1(1), ELK4(1), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(14), FLNB(4), FLNC(6), FOS(1), GADD45B(1), GNA12(2), IKBKB(2), IL1R1(2), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(1), MKNK1(1), NFATC2(1), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(3), NRAS(1), NTF3(1), NTRK1(4), NTRK2(1), PAK1(2), PDGFRB(5), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PPM1B(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTPRR(2), RAP1B(2), RAPGEF2(4), RASA2(1), RASGRF1(5), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA2(2), RPS6KA3(5), RRAS2(3), SOS1(1), SOS2(4), SRF(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(2), TAOK3(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF1A(2), TRAF2(2), ZAK(1)	106096597	387	146	385	140	150	43	63	70	60	1	0.494	1.000
227	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(1), ABP1(9), ACMSD(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), KYNU(3), MAOB(1), SDS(4), TDO2(2), TPH1(3)	21968333	88	44	86	22	36	13	20	14	5	0	0.497	1.000
228	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), TNFAIP3(1), TRAF3(3)	7318170	24	16	23	9	3	3	4	10	4	0	0.499	1.000
229	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(3), ADCY9(5), AK1(1), ARF4(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), GNAS(3), PLCG1(3), PLCG2(11), PRKCA(3), SEC61A1(1), TRIM23(1)	14879216	59	32	59	22	24	11	12	5	7	0	0.499	1.000
230	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(4), PC(3), PDHA1(1), SLC25A11(3)	3635305	13	9	13	5	3	1	4	4	1	0	0.501	1.000
231	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(1), ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(3), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), NEU4(4), PPAP2C(1), SGMS1(1), SGMS2(1), SMPD3(1), SPHK1(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(2)	13471713	44	28	46	18	16	8	4	5	10	1	0.501	1.000
232	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(2), ALAS2(1), CPOX(1), FECH(3), HMBS(1), PPOX(2), UROD(1), UROS(1)	3096938	12	8	12	1	2	1	3	3	3	0	0.501	1.000
233	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(3), C7(6), C8A(3), C9(1), MASP1(2), MBL2(1)	8383457	30	18	29	23	9	3	8	7	2	1	0.503	1.000
234	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PAK1(2)	5856060	16	13	16	5	1	4	4	4	3	0	0.506	1.000
235	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(8), AKT1(1), BCL2(3), CSF2RB(4), IGF1R(2), KIT(3), KITLG(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6807436	26	17	26	5	11	3	6	4	2	0	0.508	1.000
236	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ADC(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EARS2(2), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GFPT2(2), GLS(3), GLUD2(4), GLUL(1), GMPS(1), GOT1(1), GSR(1), GSS(1), NADSYN1(4), NAGK(2), QARS(3)	15751750	59	32	59	13	14	9	15	17	3	1	0.508	1.000
237	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(3), IL22RA1(1), JAK1(3), JAK2(4), JAK3(4), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), TYK2(3)	7302229	26	16	24	6	12	2	6	5	1	0	0.510	1.000
238	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(8), DVL2(2), EDNRB(1), EP300(5), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GSK3B(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MITF(2), NRAS(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), TCF7(3), TCF7L2(3), TYR(5), TYRP1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4)	42059694	170	77	166	50	56	20	39	31	22	2	0.510	1.000
239	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(4)	1930467	7	5	7	2	0	1	1	4	1	0	0.515	1.000
240	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CCNE1(1), CDKN1B(3), CUL1(5)	2609413	9	7	9	3	2	2	2	0	3	0	0.516	1.000
241	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), CHUK(4), GH1(1), GHR(3), NFKB1(1), NFKBIA(2), PPP2CA(1)	4158788	13	10	12	4	3	2	2	4	2	0	0.517	1.000
242	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), B4GALT2(1), G6PC(2), GAA(3), GALE(2), GALK1(3), GALK2(5), GALT(1), GANC(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2), RDH13(1), UGP2(1)	15097310	59	32	55	14	30	5	11	8	5	0	0.521	1.000
243	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(2), ARHGDIB(4), CASP1(4), GZMB(3), PRF1(3)	5217895	17	11	17	7	3	4	2	4	4	0	0.523	1.000
244	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(2)	827895	2	2	2	2	1	0	1	0	0	0	0.528	1.000
245	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1)	4061066	14	9	14	4	5	4	1	0	4	0	0.529	1.000
246	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDPS(2), HMGCR(1), LSS(1), MVD(1), MVK(1), NQO2(1), PMVK(1), SC5DL(2), SQLE(1)	4352042	15	10	14	1	6	0	3	3	3	0	0.535	1.000
247	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), SQLE(1)	1248932	3	3	3	0	1	0	0	2	0	0	0.537	1.000
248	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(1), LEPR(1), PRKAA2(1), PRKAG1(2), PRKAG2(5)	5919449	18	12	18	3	8	1	5	1	3	0	0.539	1.000
249	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), ADRB2(1), CFTR(7), GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5000185	22	13	22	6	11	3	4	2	2	0	0.542	1.000
250	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(5), AMY2B(1), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHX58(2), ENPP3(1), EP400(15), ERCC2(1), ERCC3(2), G6PC(2), GAA(3), GANC(1), GBA(1), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), IFIH1(2), MGAM(7), MOV10L1(2), PGM3(2), PYGB(4), PYGL(1), PYGM(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SI(3), SKIV2L2(1), SMARCA2(5), SMARCA5(2), TREH(2), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A1(5), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B28(5), UGT2B4(5), UGT2B7(3), UXS1(1)	48283018	159	79	156	56	56	23	34	28	18	0	0.542	1.000
251	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(3), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFKB1(1), NSMAF(3), RIPK1(1), TNFRSF1A(2), TRAF2(2)	8274482	23	18	23	7	5	4	4	5	5	0	0.546	1.000
252	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(9), ACY1(1), ADC(2), AGMAT(1), ALDH18A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CPS1(6), GATM(2), MAOB(1), ODC1(1), OTC(2), SAT1(1), SAT2(1)	11918551	43	25	43	9	13	10	8	12	0	0	0.549	1.000
253	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(1), CERK(1), CREB3(1), CREB5(1), DAG1(2), EPHB2(6), FOS(1), GNAQ(1), ITPKB(2), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2)	11048405	40	24	40	11	12	4	10	9	5	0	0.552	1.000
254	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(1), CUL1(5), FBXW7(2)	2642751	8	7	8	4	3	1	2	0	2	0	0.552	1.000
255	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	3235255	15	8	15	3	5	5	3	2	0	0	0.559	1.000
256	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1)	3235255	15	8	15	3	5	5	3	2	0	0	0.559	1.000
257	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(2), ACADS(4), ACADVL(3), ACSL3(3), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1)	6771058	20	14	21	4	6	3	4	5	2	0	0.560	1.000
258	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), GNAQ(1), ITPKB(2)	2334197	6	6	6	1	2	0	0	2	2	0	0.561	1.000
259	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1)	4066968	13	10	12	1	7	1	2	3	0	0	0.562	1.000
260	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAS1(2), ALAS2(1), CPO(3), FECH(3), GATA1(1), HMBS(1), UROD(1), UROS(1)	3207720	13	7	13	2	2	3	2	4	2	0	0.563	1.000
261	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM1(1), CCL2(2), FOS(1), GNAQ(1), MAPK14(1), PLCG1(3), PRKCA(3), PTK2B(1), SYT1(1)	5281234	14	11	14	9	3	2	2	6	1	0	0.566	1.000
262	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	653274	2	2	2	0	0	1	1	0	0	0	0.570	1.000
263	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSR(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1)	8192219	30	16	29	7	14	2	7	6	1	0	0.579	1.000
264	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), AKT2(1), AKT3(1), BCL2(3), BCR(1), BLNK(2), BTK(1), CD19(2), CD22(5), CR2(6), DAG1(2), FLOT1(2), GSK3B(1), INPP5D(6), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NR0B2(3), PIK3CD(2), PLCG2(11), PPP3CB(1), PTPRC(4), SOS1(1), SOS2(4), SYK(2), VAV1(6)	27675255	108	53	107	32	43	14	20	16	15	0	0.580	1.000
265	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GLS(3), GLUL(1), GMPS(1), GOT1(1), GSS(1), NADSYN1(4), QARS(3)	13204749	46	26	46	9	10	9	11	13	3	0	0.582	1.000
266	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(9), ACOT12(1), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4)	18815701	65	37	65	20	22	6	16	13	8	0	0.584	1.000
267	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(2), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), MAPK8IP3(5), PAPPA(6), RPS6KA3(5), SOS1(1), SYK(2), VAV1(6), VAV2(3), VAV3(2)	12633746	48	26	48	14	18	9	9	8	4	0	0.585	1.000
268	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), SOAT2(2)	9397592	38	19	38	9	16	10	8	4	0	0	0.599	1.000
269	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(1), IL12B(1), IL16(4), IL2(1), IL4(1), IL6(2)	3964825	11	8	11	5	2	1	2	4	2	0	0.599	1.000
270	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), AKT2(1), AKT3(1), CDKN1A(1), ELK1(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(2), SOS1(1)	5448617	15	12	15	6	6	3	1	3	2	0	0.605	1.000
271	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(3), ELK1(1), FOS(1), INSR(5), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SLC2A4(3), SOS1(1), SRF(2)	8615025	29	17	29	8	8	6	5	6	4	0	0.606	1.000
272	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3), ERBB3(4), NRG1(4)	3105556	11	7	11	2	4	0	3	3	1	0	0.607	1.000
273	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA4(1), ANXA5(1), CYP11A1(1), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(4), PRL(3), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS1(2), SCGB1A1(1), TBXAS1(3)	8177226	31	16	31	9	9	6	3	8	4	1	0.609	1.000
274	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), MAPK1(3), MAPK3(2), MYT1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SRC(2)	7939238	31	19	31	7	14	3	5	6	3	0	0.610	1.000
275	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(8), ACACB(9), ACADM(2), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLA2(1), SUCLG1(2)	16123336	52	29	52	13	16	7	13	8	8	0	0.612	1.000
276	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), AKT2(1), AKT3(1), IARS(4), IL13RA1(1), IL4(1), IL4R(6), INPP5D(6), JAK1(3), JAK2(4), JAK3(4), NR0B2(3), RPS6KB1(1), SOS1(1), SOS2(4), SRC(2), STAT6(3), TYK2(3)	13804452	49	27	47	15	22	10	6	7	4	0	0.616	1.000
277	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(2), HLA-DRA(1), HLA-DRB1(2)	1233437	6	3	6	0	0	3	0	2	1	0	0.616	1.000
278	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAR2A(1), PRKAR2B(1)	5958974	25	15	25	6	12	1	6	4	2	0	0.617	1.000
279	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(4), ABCA10(2), ABCA12(2), ABCA13(5), ABCA2(3), ABCA4(6), ABCA5(4), ABCA6(2), ABCA7(3), ABCA8(1), ABCA9(4), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(8), ABCB5(7), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(2), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(5), ABCC4(4), ABCC5(7), ABCC6(5), ABCC8(6), ABCD1(4), ABCD2(4), ABCD3(2), ABCG1(2), ABCG2(2), ABCG4(6), ABCG5(3), ABCG8(3), CFTR(7), TAP1(4), TAP2(2)	44048101	148	71	147	57	53	18	32	19	23	3	0.617	1.000
280	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(6), HLA-DRA(1), HLA-DRB1(2), ITGAL(4), ITGB2(5), PTPRC(4)	5799042	27	11	26	13	6	6	7	1	7	0	0.619	1.000
281	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	ABO(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT4(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GCNT2(1), ST3GAL6(2)	6100494	22	13	22	9	8	3	4	6	1	0	0.621	1.000
282	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), IMPDH1(2), OAZ1(1), POLD1(3), POLG(4), PRPS2(2), RRM1(2)	4959256	15	10	14	6	4	2	3	3	3	0	0.625	1.000
283	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(1), ALDOC(3), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GAPDHS(2), GCK(2), GOT1(1), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6B(1), LDHC(1), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PKLR(4)	16619362	68	32	67	20	26	11	11	13	7	0	0.625	1.000
284	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(2), VAMP2(1)	1301392	3	3	3	1	2	0	0	0	1	0	0.627	1.000
285	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), BIRC3(1), DFFA(1), DFFB(3), GZMB(3), PRF1(3), SCAP(5), SREBF1(2), SREBF2(3)	7117067	23	16	23	9	8	1	4	4	6	0	0.628	1.000
286	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ABAT(2), ACADS(4), ACSM1(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(1), RDH13(1)	16399088	52	32	53	20	18	7	10	9	8	0	0.629	1.000
287	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(8), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CREBBP(8), EP300(5), GNAQ(1), GRIA1(4), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NRAS(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RAP1B(2), RAPGEF3(1), RPS6KA2(2), RPS6KA3(5)	38930540	149	68	146	54	52	23	34	25	13	2	0.635	1.000
288	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	ACTR3(2), AKT1(1), ANGPTL2(2), DAG1(2), GCA(1), ITGA9(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), MAP2K1(1), MAPK1(3), MAPK3(2), NR1I3(2), PAK1(2), PDE3A(1), PDE3B(4), PIK3CD(2), PLDN(1), PSME1(1), RIPK3(2), RPS4X(1), VASP(2)	16749545	64	34	64	17	18	11	14	10	11	0	0.635	1.000
289	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(6), LPO(1), MPO(3), PRDX2(2), SHMT2(1), TPO(4)	4676705	17	11	17	9	11	0	2	1	3	0	0.639	1.000
290	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(3), GREB1(2), MTA1(4), MTA3(2), PDZK1(1), TUBA8(4)	4036321	18	10	18	7	7	2	5	1	3	0	0.643	1.000
291	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(2), IL10RA(1), IL6(2), JAK1(3), STAT1(1), STAT3(2), STAT5A(2)	4931464	15	10	15	4	4	2	2	3	4	0	0.646	1.000
292	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(4), NR1I3(2), PTGS1(2)	2149083	8	5	8	5	3	0	3	1	1	0	0.648	1.000
293	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(2), FOS(1), MAPK14(1), THBS1(3)	2982491	7	6	7	4	1	2	0	3	1	0	0.658	1.000
294	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), IL4(1)	1253980	6	3	6	0	2	2	0	2	0	0	0.660	1.000
295	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(1), UXS1(1)	1560555	5	3	5	0	2	2	0	1	0	0	0.661	1.000
296	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), EIF4E(2), FBL(1), LDHA(2), LDHC(1), MAPK14(1), NCL(3)	3536753	14	7	14	3	4	1	1	5	3	0	0.662	1.000
297	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), ENPP2(5), PAFAH2(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLD2(1), PPAP2C(1)	9229215	32	19	32	17	13	3	4	5	6	1	0.662	1.000
298	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CALM1(1), ELK1(1), FOS(1), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), MAP2K1(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RPS6KA3(5), SYT1(1)	13613042	43	27	43	15	12	6	8	12	5	0	0.663	1.000
299	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(2)	1249454	4	3	4	2	1	1	0	0	2	0	0.663	1.000
300	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT2(1), DDOST(2), DPAGT1(1), FUT8(1), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), RPN1(1), ST6GAL1(4)	7750835	24	15	24	5	6	5	3	5	5	0	0.665	1.000
301	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(3), CHUK(4), DAXX(4), EGF(3), FOS(1), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), RIPK1(1), SP1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	18655627	67	36	66	25	16	10	16	15	10	0	0.668	1.000
302	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(1), AKT2(1), AKT3(1), CARD11(6), CBL(1), CBLB(1), CBLC(1), CD28(1), CD3E(1), CD3G(1), CD8A(1), CD8B(1), CHUK(4), FOS(1), GRAP2(1), IFNG(1), IKBKB(2), IL2(1), IL4(1), ITK(3), KRAS(1), MALT1(3), MAP3K14(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDCD1(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCQ(1), PTPN6(4), PTPRC(4), RASGRP1(1), RHOA(1), SOS1(1), SOS2(4), TEC(5), VAV1(6), VAV2(3), VAV3(2), ZAP70(5)	38207200	129	64	128	56	42	17	27	27	16	0	0.671	1.000
303	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(5), MYL2(2), MYLK(7), PAK1(2), PPP1R12B(6), RALBP1(3), RPS6KB1(1), TRIO(8), VAV1(6), WASF1(1)	11688440	44	24	44	16	13	6	13	7	5	0	0.671	1.000
304	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK1(3), MAPK3(2), SOS1(1)	5980178	14	12	14	3	4	3	1	5	1	0	0.672	1.000
305	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(5), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), ATP7B(3), COX10(1), COX8A(1), NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2), PPA2(1), UQCRC1(3)	14093507	52	28	53	15	14	11	13	7	7	0	0.674	1.000
306	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(4), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2)	4233734	15	11	16	9	5	1	4	2	3	0	0.677	1.000
307	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(3), DHCR7(4), FDPS(2), GGCX(1), HMGCR(1), HSD17B7(1), IDI2(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1), TM7SF2(2)	7681268	26	16	25	7	8	2	7	3	6	0	0.681	1.000
308	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	IFNG(1), IFNGR1(1), JAK1(3), JAK2(4), PTPRU(3), STAT1(1)	4512928	13	10	12	1	9	0	1	1	2	0	0.681	1.000
309	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), NTRK1(4), PLCG1(3), PRKCA(3), SOS1(1)	4715254	12	10	12	7	3	3	2	4	0	0	0.687	1.000
310	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4)	2470997	8	5	8	5	2	1	1	3	1	0	0.687	1.000
311	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(3), CREBBP(8), EP300(5), IL7(1), IL7R(1), JAK1(3), JAK3(4), PTK2B(1), STAT5A(2), STAT5B(2)	9753607	30	18	29	12	6	5	11	4	3	1	0.688	1.000
312	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(2), ACPT(3), ENPP3(1), RFK(1), TYR(5)	3874593	12	7	12	4	2	2	2	5	1	0	0.691	1.000
313	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	28	AMDHD2(2), CHIA(2), CHIT1(1), CMAS(1), CTBS(3), GFPT1(5), GFPT2(2), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), LHPP(1), MTMR1(2), MTMR2(3), NAGK(2), PGM3(2), UAP1(1)	11119870	39	21	38	9	12	3	9	8	6	1	0.691	1.000
314	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(4), DNAJC3(3), EIF2S2(1), MAP3K14(2), NFKB1(1), NFKBIA(2)	3587258	13	7	12	4	1	1	3	5	3	0	0.691	1.000
315	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	11	FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(3)	4246550	8	8	8	7	3	2	1	0	2	0	0.694	1.000
316	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), CREB3(1), CREB5(1), MAPK1(3), SNX13(1), SRC(2), TERF2IP(3)	3828054	12	7	12	1	2	2	3	5	0	0	0.695	1.000
317	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), ESRRA(2), HDAC5(4), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CB(1), SLC2A4(3), SYT1(1)	8008658	25	16	25	7	4	4	6	7	4	0	0.695	1.000
318	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2), SDS(4)	14547809	54	27	53	15	17	12	11	7	7	0	0.695	1.000
319	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(1), MMP9(2), RECK(1), TIMP3(2)	3004129	10	7	10	1	5	1	2	1	1	0	0.695	1.000
320	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(1), BCL2(3), IGF1R(2), POLR2A(2), PPP2CA(1), PRKCA(3), TEP1(4), TERT(8), TNKS(4), XRCC5(1)	9171493	29	19	27	4	12	3	6	4	4	0	0.696	1.000
321	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(4), BIRC2(1), BIRC3(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), DFFA(1), DFFB(3), GZMB(3), LMNB1(1), LMNB2(3), PRF1(3)	7723788	28	16	28	7	4	5	5	8	6	0	0.706	1.000
322	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(1), AKT2(1), AKT3(1), BTK(1), CDKN2A(3), GSK3B(1), IARS(4), IGFBP1(1), INPP5D(6), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SOS1(1), SOS2(4), TEC(5), YWHAB(1), YWHAE(2)	13074307	42	23	42	16	13	11	5	5	8	0	0.707	1.000
323	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1)	2558268	9	7	9	1	5	1	2	1	0	0	0.707	1.000
324	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1)	2558268	9	7	9	1	5	1	2	1	0	0	0.707	1.000
325	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), FSHR(1), GNAS(3), XPO1(2)	3767123	14	10	14	3	8	1	3	1	1	0	0.708	1.000
326	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(4), IFNG(1), IKBKB(2), IL2(1), IL4(1), MAP3K1(5), MAP3K5(1), MAPK14(1), NFKB1(1), NFKBIA(2), TNFSF9(3), TRAF2(2)	7816794	25	15	24	13	8	2	3	7	5	0	0.709	1.000
327	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI2(1), SQLE(1)	1690221	4	3	4	0	1	0	0	2	1	0	0.710	1.000
328	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(3), CREBBP(8), EP300(5), MAP2K1(1), MAP3K7(2), MAPK3(2), SKIL(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5)	10432659	38	18	38	9	9	6	11	6	5	1	0.711	1.000
329	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(5), ESR1(3), ESR2(1), ESRRA(2), NPM1(1), NR1D1(3), NR1H2(1), NR1H3(1), NR1I3(2), NR2F2(2), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(2), NR5A1(1), NR5A2(1), PGR(4), PPARA(1), RARG(2), ROR1(2), RORA(1), RORC(3), RXRA(3), RXRB(1), RXRG(1), THRA(1), VDR(2)	15986444	51	33	50	27	16	2	10	12	11	0	0.717	1.000
330	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(3), ELK1(1), FOS(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2)	8341991	23	16	23	7	8	4	4	5	2	0	0.719	1.000
331	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1)	4578927	13	10	12	2	7	1	2	3	0	0	0.720	1.000
332	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTG2(2), ACTR3(2), AKT1(1), ANGPTL2(2), CFL2(1), FLNA(14), FLNC(6), FSCN3(2), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), VASP(2), WASF1(1)	16803805	59	33	59	19	20	7	15	8	9	0	0.721	1.000
333	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(2), TAX1BP3(1), UBE2A(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE3A(4)	4005221	12	8	13	1	3	2	3	1	2	1	0.721	1.000
334	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(2), EGF(3), HGS(3), TFRC(2)	4056839	10	7	10	4	0	2	2	3	3	0	0.721	1.000
335	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), AKT2(1), AKT3(1), BPNT1(1), ILK(2), MAPK1(3), MAPK3(2), PIK3CD(2), PTK2B(1), RBL2(1), SOS1(1)	6879113	16	13	16	6	4	2	3	6	1	0	0.721	1.000
336	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(1), CREBBP(8), EP300(5), ERCC3(2), ESR1(3), GRIP1(6), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), MEF2C(1), NCOR2(5), NRIP1(3), PELP1(2), POLR2A(2), TBP(2)	18281204	59	34	59	14	19	7	18	6	8	1	0.724	1.000
337	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	3135228	8	6	8	4	0	3	1	1	3	0	0.725	1.000
338	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), BCL2(3), DAXX(4), MAPKAPK2(1), MAPKAPK3(1)	4559228	11	9	11	4	2	1	4	2	2	0	0.730	1.000
339	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(2), MAPK14(1), NFKB1(1), TNFRSF13B(2), TNFSF13B(2), TRAF2(2), TRAF3(3), TRAF5(1)	5745691	18	12	17	6	4	0	4	7	3	0	0.732	1.000
340	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(2), EPHB2(6), F2(1), F2RL3(1), MAP2K5(1), MAPK1(3), MAPK7(3), PLD2(1), PTK2(2), RASAL1(3), SRC(2), TEC(5), VAV1(6)	10846676	37	21	37	12	12	8	9	6	2	0	0.732	1.000
341	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	183	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ARHGAP5(2), BCL2(3), BIRC2(1), BIRC3(1), CAPN2(1), CAV1(1), CAV3(1), CCND2(1), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DIAPH1(2), DOCK1(9), EGF(3), ELK1(1), ERBB2(7), FARP2(2), FIGF(1), FLNA(14), FLNB(4), FLNC(6), FLT1(2), FN1(3), GRLF1(4), GSK3B(1), HGF(4), IGF1R(2), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KDR(10), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(10), LAMC1(2), LAMC2(6), LAMC3(5), MAP2K1(1), MAPK1(3), MAPK3(2), MAPK9(2), MET(5), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARVB(1), PARVG(2), PDGFC(3), PDGFD(2), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), RAP1B(2), RELN(20), RHOA(1), ROCK1(3), ROCK2(4), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TLN1(6), TLN2(5), TNC(7), TNN(5), TNR(2), TNXB(6), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), VEGFA(2), VEGFC(2), VWF(10), ZYX(2)	136679796	514	162	508	178	182	88	93	74	76	1	0.735	1.000
342	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(1), BCL2(3), CABIN1(12), CALM1(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(2), CREBBP(8), CSNK2A1(3), EGR2(3), EGR3(4), EP300(5), FCER1A(3), FCGR3A(1), FOS(1), GATA3(2), GATA4(2), GRLF1(4), GSK3B(1), IFNB1(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), IL6(2), ITK(3), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(3), P2RX7(2), PAK1(2), PPP3CB(1), PPP3R1(1), PTPRC(4), SLA(1), SP1(6), SP3(1), TGFB1(1), TRAF2(2), VAV1(6), VAV2(3), VAV3(2), XPO5(1)	35016704	130	57	130	38	33	21	32	20	23	1	0.736	1.000
343	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRB1(1), DRD1(2), DRD2(1), EGF(3), GJA1(1), GNA11(2), GNAI2(1), GNAQ(1), GNAS(3), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(2), MAPK7(3), NPR2(1), NRAS(1), PDGFC(3), PDGFD(2), PDGFRB(5), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKG2(5), PRKX(2), SOS1(1), SOS2(4), SRC(2), TJP1(2), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	49674282	177	83	173	69	69	22	33	26	26	1	0.737	1.000
344	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(2), ELOVL5(1), FADS1(1), FADS2(1), FASN(7), HADHA(1), PECR(1), SCD(2)	5319808	20	12	20	3	6	3	4	4	3	0	0.738	1.000
345	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(3), ACVRL1(2), AKT1(1), BMPR1A(2), BMPR2(2), BUB1(4), CDKL1(3), CDS1(1), CLK2(2), CLK4(2), CSNK2A1(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11), PLK3(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TGFBR1(1)	42886776	152	70	150	44	49	30	25	25	22	1	0.739	1.000
346	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(1), CAMK1(2), ELK1(1), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NCF1(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PAK1(2), PLCB1(3), PPP3CB(1), SYT1(1)	14267583	44	24	44	18	7	7	10	11	8	1	0.745	1.000
347	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(1), FUT9(1), GCNT2(1)	2428650	7	5	7	3	3	1	1	1	1	0	0.745	1.000
348	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(1), AFMID(3), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1)	5436982	14	11	14	7	7	1	4	2	0	0	0.747	1.000
349	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	75	AIFM1(4), AKT1(1), AKT2(1), AKT3(1), APAF1(1), ATM(7), BCL2(3), BIRC2(1), BIRC3(1), CAPN1(5), CAPN2(1), CASP6(1), CHUK(4), CSF2RB(4), DFFA(1), DFFB(3), IKBKB(2), IL1R1(2), IL1RAP(2), IRAK1(2), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RIPK1(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(5), TRAF2(2)	30829292	105	53	104	37	33	17	20	25	10	0	0.748	1.000
350	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(1), NFKBIA(2)	4989920	15	9	13	3	6	2	3	3	1	0	0.752	1.000
351	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), MIOX(1)	3423771	9	7	9	3	4	1	2	2	0	0	0.755	1.000
352	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4)	3366834	9	6	9	3	1	3	1	1	3	0	0.755	1.000
353	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	26	HLA-DRA(1), HLA-DRB1(2), IFNB1(1), IFNG(1), IL12B(1), IL2(1), IL4(1), IL6(2), IL7(1), TGFB1(1), TGFB2(1)	4819639	13	9	13	4	2	3	1	3	4	0	0.756	1.000
354	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B2(2)	3278617	8	6	8	6	2	0	4	0	2	0	0.756	1.000
355	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	55	BTK(1), CAD(6), CASP8AP2(3), CD7(2), DAXX(4), DFFA(1), DIABLO(1), EPHB2(6), FAF1(3), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MET(5), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(3), PTPN13(4), RALBP1(3), RIPK1(1), ROCK1(3), TNFRSF6B(2), TPX2(1), TRAF2(2), TUFM(1)	26133317	86	43	86	27	24	15	20	17	10	0	0.756	1.000
356	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(3), EGF(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2)	12542902	33	21	33	12	10	7	5	7	4	0	0.758	1.000
357	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(3), THTPA(1)	2569519	7	4	7	1	2	1	2	1	1	0	0.759	1.000
358	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	16	CBL(1), EGF(3), MAP2K1(1), MAPK1(3), MAPK3(2), PTPRB(4), SOS1(1), SPRY1(1), SPRY2(2), SRC(2)	8602278	20	14	19	9	5	2	3	7	3	0	0.759	1.000
359	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	851992	1	1	1	2	0	1	0	0	0	0	0.762	1.000
360	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	661770	1	1	1	1	1	0	0	0	0	0	0.764	1.000
361	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY7(3), ADCY8(4), ADCY9(5), ADORA2B(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(4), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), ATP2B4(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CCKAR(3), CCKBR(2), CD38(2), CHRM2(4), CHRM3(3), CHRNA7(2), CYSLTR1(1), CYSLTR2(1), DRD1(2), EDNRA(1), EDNRB(1), ERBB2(7), ERBB3(4), ERBB4(1), GNA11(2), GNA15(4), GNAL(1), GNAQ(1), GNAS(3), GRIN1(3), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HRH1(1), HRH2(5), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), LHCGR(1), LTB4R2(2), MYLK(7), MYLK2(1), NOS1(9), NOS3(5), NTSR1(2), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), PDE1A(1), PDE1C(4), PDGFRB(5), PHKA1(3), PHKA2(4), PHKB(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PPID(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(14), RYR3(17), SLC25A5(2), SLC8A1(2), SLC8A3(2), SPHK1(1), TACR1(1), TACR3(4), TNNC1(1), TRHR(2), TRPC1(1), VDAC1(1), VDAC2(1)	99425284	435	141	432	141	193	52	77	64	48	1	0.773	1.000
362	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(5)	7433431	23	14	23	7	7	4	3	4	5	0	0.775	1.000
363	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	18	ADCY1(8), AKT1(1), ASAH1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(1), MAPK1(3), MAPK3(2), PLCB1(3), PRKCA(3), PTK2(2), SPHK1(1), SRC(2)	8431125	30	17	31	6	13	5	5	4	2	1	0.775	1.000
364	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR2(2), SNAP23(1), SNAP25(2), SNAP29(1), STX11(1), STX19(1), STX2(1), STX3(1), STX4(1), STX5(2), STX7(1), STX8(1), TSNARE1(2), USE1(1), VAMP2(1), VAMP5(1)	6371131	20	12	20	7	6	3	1	5	5	0	0.777	1.000
365	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(3), KARS(4)	2839594	9	5	9	3	0	2	1	4	2	0	0.779	1.000
366	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(4), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2)	6718112	21	12	20	4	11	1	5	3	1	0	0.779	1.000
367	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), GABARAPL1(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(2), PRKAA2(1), ULK1(1), ULK2(6), ULK3(1)	8181741	23	13	23	5	4	2	7	5	5	0	0.781	1.000
368	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	AKR1B10(2), ALOX15(2), ALOX5(1), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP3A4(3), CYP3A43(2), CYP3A7(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), RDH13(1)	9501740	38	17	38	13	15	2	8	8	4	1	0.781	1.000
369	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), CCL5(1), CHUK(4), CXCL1(1), F11R(1), GIT1(2), IKBKB(2), JAM2(1), JAM3(1), LYN(1), MAP3K14(2), MAPK13(1), MAPK14(1), MAPK9(2), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(11), PTPN11(6), PTPRZ1(3), SRC(2), TCIRG1(2), TJP1(2)	26992127	94	46	93	39	30	14	20	19	11	0	0.782	1.000
370	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(2), AGXT2(2), ASNS(1), CAD(6), GAD1(4), GAD2(3), GOT1(1), NARS(1), PC(3)	10342147	26	19	26	13	5	5	7	6	3	0	0.782	1.000
371	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(2), EP300(5), EPO(1), HIF1A(1), LDHA(2), NOS3(5), VHL(1)	6659170	18	11	18	9	4	0	5	6	2	1	0.782	1.000
372	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(1), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1)	5187062	11	10	11	7	5	1	4	1	0	0	0.785	1.000
373	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), CALM1(1), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK14(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYK(2), SYT1(1), VAV1(6)	15272232	40	26	40	23	9	7	8	11	5	0	0.785	1.000
374	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CD3E(1), CD3G(1), ELK1(1), FOS(1), MAP2K1(1), MAP3K1(5), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYT1(1), VAV1(6), ZAP70(5)	17550822	43	30	43	25	11	7	9	9	7	0	0.788	1.000
375	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(1), CALM1(1), GNAS(3), GNB1(1), GNGT1(1), NFKB1(1), NOS3(5), NR3C1(1), SYT1(1)	5500194	16	10	16	8	5	2	3	3	3	0	0.788	1.000
376	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), AGTR1(2), ATF2(1), CALM1(1), ELK1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP3K1(5), MAPK1(3), MAPK3(2), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(2), PRKCA(3), PTK2(2), PTK2B(1), SOS1(1), SRC(2), SYT1(1)	12443946	36	21	36	14	8	6	9	10	3	0	0.791	1.000
377	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1)	530101	1	1	1	1	0	1	0	0	0	0	0.791	1.000
378	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1)	738713	1	1	1	0	1	0	0	0	0	0	0.792	1.000
379	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(1), UGP2(1), UXS1(1)	1991565	6	3	6	0	2	2	1	1	0	0	0.792	1.000
380	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), PAK1(2), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), SRC(2), SYT1(1)	11397828	29	20	29	13	6	5	4	10	4	0	0.795	1.000
381	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUD2(4), GLUL(1), HAL(2)	8479240	33	16	33	7	14	4	7	4	4	0	0.796	1.000
382	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(4), FDPS(2), HMGCR(1), HMGCS1(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1)	5222852	16	9	15	3	5	0	5	3	3	0	0.799	1.000
383	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(1), CSF1R(3), EGF(3), MET(5), PRKCA(3), SH3GLB1(2), SH3GLB2(4), SH3KBP1(3), SRC(2)	5899232	26	11	26	7	8	4	5	5	4	0	0.799	1.000
384	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), DUSP14(1), EIF4E(2), IFNG(1), IL1R1(2), NR4A3(1), WDR1(2)	4340112	11	7	11	6	1	2	0	5	3	0	0.800	1.000
385	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(8), ARHGEF1(2), F2(1), F2RL3(1), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MAP3K7(2), PLCB1(3), PPP1R12B(6), PRKCA(3), PTK2B(1), ROCK1(3)	8809860	35	17	35	8	13	3	8	8	2	1	0.802	1.000
386	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(9), AOC2(2), AOC3(2), CES1(2), DDHD1(1), ESCO1(2), MYST3(4), MYST4(4), PLA1A(1), PNPLA3(1), SH3GLB1(2)	10220356	31	19	31	6	11	5	5	6	4	0	0.802	1.000
387	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(8), GLI3(3), GSK3B(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(2), SUFU(2)	6443477	25	12	24	16	6	8	4	5	2	0	0.805	1.000
388	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2)	11521437	30	19	30	10	10	7	4	5	4	0	0.805	1.000
389	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL14(1), RPL18A(2), RPL22L1(1), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL36A(1), RPL36AL(1), RPL39(1), RPL8(1), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(2), RPSA(1)	8850132	29	18	28	11	9	4	6	4	6	0	0.807	1.000
390	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ABI2(2), ACTN1(1), ACTN3(1), ACTN4(4), APC(7), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF4(2), ARHGEF7(1), ARPC1B(1), ARPC2(1), ARPC4(1), ARPC5L(1), BDKRB1(1), BDKRB2(3), CD14(2), CFL2(1), CHRM2(4), CHRM3(3), CYFIP1(2), CYFIP2(1), DIAPH1(2), DIAPH2(3), DIAPH3(4), DOCK1(9), EGF(3), EZR(3), F2(1), FGD1(2), FGD3(2), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FN1(3), GIT1(2), GNA12(2), GRLF1(4), GSN(2), IQGAP1(2), IQGAP2(4), IQGAP3(5), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KRAS(1), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MSN(1), MYH10(3), MYH14(6), MYH9(8), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), NCKAP1(2), NCKAP1L(4), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(6), PTK2(2), PXN(1), RHOA(1), ROCK1(3), ROCK2(4), RRAS2(3), SLC9A1(3), SOS1(1), SOS2(4), SSH1(1), SSH2(4), SSH3(2), TIAM1(2), TIAM2(8), TMSL3(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), WASF1(1), WASF2(1)	104274379	374	138	370	136	137	43	81	55	58	0	0.807	1.000
391	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), ADRB2(1), GNAS(3), PLCE1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5703176	22	12	22	3	9	3	4	3	3	0	0.808	1.000
392	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(8), EP300(5), IKBKB(2), MAP2K3(1), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), NR3C1(1), TGFBR1(1), TGFBR2(5), TLR2(4)	11876729	39	20	38	13	6	7	10	9	6	1	0.809	1.000
393	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), CDKN1B(3), ILK(2), MAPK1(3), MAPK3(2), PTK2(2), SOS1(1)	5828210	14	10	14	3	2	3	3	4	2	0	0.812	1.000
394	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP54(1), SRPR(4)	3024644	6	5	6	2	2	0	2	0	2	0	0.813	1.000
395	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2RL3(1), GNB1(1), GNGT1(1), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), PLA2G4A(4), PLCB1(3), PRKCA(3), PTGS1(2), PTK2(2), SRC(2), SYK(2), TBXAS1(3)	9811189	32	16	32	8	11	5	5	7	2	2	0.813	1.000
396	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	44	ACOX1(2), APOA2(1), CD36(2), CREBBP(8), EHHADH(2), EP300(5), HSD17B4(1), MAPK1(3), MAPK3(2), ME1(4), MRPL11(1), NCOA1(3), NCOR1(5), NCOR2(5), NFKBIA(2), NR0B2(3), NR1H3(1), NRIP1(3), PPARA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RXRA(3), SP1(6), STAT5A(2), STAT5B(2)	22308002	73	38	74	24	18	7	19	17	10	2	0.813	1.000
397	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(3), PDE6D(1)	1564927	4	3	4	1	0	1	2	0	1	0	0.813	1.000
398	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADHA(1), HSD17B10(1), HSD17B4(1), MECR(2)	3446007	6	5	6	1	1	1	0	2	2	0	0.815	1.000
399	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC1(2), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1)	2977124	7	5	7	2	3	1	2	0	1	0	0.817	1.000
400	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	ACTA1(1), AGT(3), AKT1(1), CALM1(1), CAMK1(2), CAMK4(1), CREBBP(8), ELSPBP1(1), F2(1), FGF2(1), FKBP1A(1), GATA4(2), GSK3B(1), MAP2K1(1), MAPK1(3), MAPK14(1), MAPK3(2), MEF2C(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KB1(1), SYT1(1)	16776281	45	28	45	20	5	8	11	13	8	0	0.818	1.000
401	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2)	9862884	28	17	28	6	10	3	6	5	4	0	0.819	1.000
402	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUL(1), HAL(2)	7581930	29	14	29	6	12	4	5	4	4	0	0.821	1.000
403	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(1), CREBBP(8), EP300(5), NCOA3(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RXRA(3)	7782844	24	14	25	6	5	4	7	4	3	1	0.821	1.000
404	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(1), DOCK1(9), ELK1(1), FOS(1), GAB1(1), HGF(4), ITGA1(1), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK1(3), MAPK3(2), MET(5), PAK1(2), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), SOS1(1), SRC(2), STAT3(2)	15909130	50	28	50	10	15	8	10	13	4	0	0.822	1.000
405	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), BCL2(3), CBL(1), FOS(1), IL2RA(3), IL2RB(1), IRS1(4), JAK1(3), JAK3(4), MAPK1(3), MAPK3(2), PTPN6(4), RPS6KB1(1), SOCS1(1), SOS1(1), STAT5A(2), STAT5B(2), SYK(2)	12825362	39	23	38	12	10	4	11	10	4	0	0.823	1.000
406	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(8), EP300(5), HDAC3(1), IKBKB(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2)	9036928	28	15	27	12	4	4	9	6	4	1	0.824	1.000
407	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), NDST1(2), NDST2(2), NDST3(2), NDST4(5)	8299249	37	17	37	7	10	5	10	5	7	0	0.825	1.000
408	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(7), BMPR1B(1), CCND2(1), CDKN1B(3), EGR1(2), ESR2(1), FSHR(1), LHCGR(1), MSH5(3), NCOR1(5), NR5A1(1), NRIP1(3), PGR(4), PTGER2(2), VDR(2), ZP2(2)	14056328	39	23	39	12	11	5	12	4	6	1	0.829	1.000
409	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTAP(1), MTFMT(1), MTR(2), TAT(3)	8300658	28	16	28	9	11	9	2	3	3	0	0.830	1.000
410	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(1), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(4), GRIA3(5), GRID2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IGF1R(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NOS1(9), NOS3(5), NPR2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(4), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(3), PRKCG(1), PRKG2(5), RYR1(14)	42481798	158	71	155	62	66	21	27	21	21	2	0.831	1.000
411	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CCNE1(1), CUL1(5)	2747020	7	5	7	4	3	1	2	0	1	0	0.835	1.000
412	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(1), ABLIM2(1), ABLIM3(2), CFL2(1), DCC(9), DPYSL2(2), DPYSL5(2), EFNA3(2), EFNA5(2), EFNB1(2), EFNB2(2), EFNB3(1), EPHA2(2), EPHA3(2), EPHA4(3), EPHA5(4), EPHA6(2), EPHA7(6), EPHA8(6), EPHB1(10), EPHB2(6), EPHB3(1), EPHB4(2), EPHB6(5), FES(3), GNAI2(1), GSK3B(1), KRAS(1), L1CAM(7), LIMK1(1), LIMK2(1), LRRC4C(3), MAPK1(3), MAPK3(2), MET(5), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), NRP1(5), NTN1(3), NTN4(2), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLXNA1(3), PLXNA2(8), PLXNA3(3), PLXNB1(3), PLXNB3(7), PLXNC1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTK2(2), RGS3(2), RHOA(1), RHOD(1), RND1(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(4), SEMA3A(1), SEMA3B(1), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(3), SEMA4G(3), SEMA5A(2), SEMA5B(2), SEMA6B(1), SEMA6C(1), SEMA7A(1), SLIT1(4), SLIT2(5), SRGAP1(5), SRGAP2(2), SRGAP3(4), UNC5A(4), UNC5D(2)	71958279	234	105	232	83	63	41	49	46	35	0	0.837	1.000
413	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(2), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), NOX1(2), PLCB1(3), PPP1R12B(6), PRKCA(3), PTK2(2), ROCK2(4)	9085995	37	14	37	9	9	7	11	7	2	1	0.839	1.000
414	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(1), CAPN1(5), CAPN2(1), CAPNS1(1), CXCR3(2), EGF(3), ITGA1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(6)	11849096	40	21	40	11	13	3	9	12	3	0	0.839	1.000
415	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(7), ATR(9)	5823225	16	9	16	3	4	4	2	4	2	0	0.839	1.000
416	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7)	6680545	20	11	19	10	4	4	5	3	3	1	0.841	1.000
417	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(2), GFPT1(5), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), PGM3(2), UAP1(1)	6734770	23	12	22	3	10	2	4	4	3	0	0.841	1.000
418	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(1), LDHA(2), LDHC(1), MPST(1)	2737319	6	4	6	1	1	1	2	1	1	0	0.843	1.000
419	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	3357368	9	6	9	6	3	2	2	2	0	0	0.844	1.000
420	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(8), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), GNAS(3), MAPK1(3), MAPK14(1), MAPK3(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SOS1(1)	9904478	31	19	31	12	11	4	5	10	1	0	0.844	1.000
421	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(2), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MYL2(2), MYLK(7), PLCB1(3), PPP1R12B(6), PRKCA(3), ROCK1(3)	8359857	33	14	33	9	10	3	10	6	3	1	0.844	1.000
422	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(5), CAPNS1(1), CDK5R1(1), GSK3B(1), MAPT(1), PPP2CA(1)	3492849	12	6	12	2	5	1	3	3	0	0	0.844	1.000
423	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), ABCG2(2), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1)	9335101	25	17	25	16	7	5	4	4	5	0	0.845	1.000
424	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	AKT1(1), AKT2(1), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(2), DAG1(2), EPHB2(6), ITPKB(2), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(2), PLCG2(11), SOS1(1), SOS2(4), SYK(2), VAV1(6)	18418967	61	32	61	25	24	9	11	11	6	0	0.845	1.000
425	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DAXX(4), DDIT3(1), ELK1(1), HMGN1(1), MAP3K1(5), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(4), RIPK1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2)	14709253	37	23	37	8	10	6	5	10	5	1	0.846	1.000
426	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), GCK(2), GMDS(1), GMPPA(1), HK2(3), HK3(4), MPI(1), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1)	9558665	39	18	38	5	17	5	7	9	1	0	0.846	1.000
427	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	GNAQ(1), GNB1(1), GNGT1(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(1), PXN(1)	8497039	20	14	20	9	4	2	5	7	2	0	0.848	1.000
428	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(4), GAPDH(1), INSR(5), ITCH(1), MAGI1(2), MAGI2(4), RERE(5), WWP2(2)	9532109	26	17	26	13	9	6	2	6	3	0	0.849	1.000
429	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(7), CDC25B(1), MYT1(7)	5167848	15	9	15	0	5	3	2	2	3	0	0.852	1.000
430	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(1), EPO(1), EPOR(1), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PLCG1(3), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2)	8596885	26	15	25	7	13	2	6	3	2	0	0.853	1.000
431	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(3), BTK(1), CFL2(1), INPPL1(4), ITPR1(7), ITPR2(11), ITPR3(11), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CD(2), PIK3CG(12), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), WASF1(1)	25865054	89	45	89	31	34	13	19	10	13	0	0.853	1.000
432	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	FURIN(1), NOTCH1(4)	3187804	5	5	3	2	0	0	0	5	0	0	0.854	1.000
433	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), CNR2(3), DNMT1(5), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1)	4337739	20	9	20	8	6	2	1	8	3	0	0.856	1.000
434	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), MAP2K3(1), MAPK14(1), NFATC1(3), NFATC2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	4513284	12	8	12	9	2	0	1	5	4	0	0.857	1.000
435	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNB1(1), CHRNG(1), MUSK(1), PTK2(2), PTK2B(1), SRC(2), TERT(8)	4859970	17	9	17	4	9	3	2	1	2	0	0.858	1.000
436	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(7), AXIN1(2), BTRC(1), CREBBP(8), CSNK2A1(3), CTBP1(3), FZD1(1), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(6), WIF1(2)	11291036	38	19	38	10	11	4	8	9	6	0	0.859	1.000
437	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(1), DLD(1), DUSP10(1), DUSP4(3), DUSP8(1), GAB1(1), GCK(2), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK7(3), MAPK9(2), NFATC3(1), PAPPA(6), ZAK(1)	19763110	55	34	53	21	23	6	7	11	8	0	0.860	1.000
438	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	30	GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2F1(1), GTF2H4(1), GTF2IRD1(2), TAF1(4), TAF1L(14), TAF2(2), TAF4(2), TAF4B(1), TAF5(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(2), TAF9(1), TBPL2(2)	14193225	45	22	43	14	13	4	14	6	8	0	0.862	1.000
439	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(3), ABAT(2), ACY3(1), ADSSL1(1), AGXT2(2), ASNS(1), CAD(6), DLAT(1), DLD(1), GAD1(4), GAD2(3), GOT1(1), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1)	15040466	39	25	39	20	12	8	8	6	5	0	0.863	1.000
440	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT2(1), FUT8(1), ST3GAL1(2), ST3GAL3(1)	3137179	7	5	7	1	2	2	2	0	1	0	0.867	1.000
441	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2D(1), CAMK2G(4), DAG1(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFAT5(3), PDE6A(4), PDE6B(7), PDE6C(1), PDE6D(1), SLC6A13(2)	14093721	57	26	57	15	20	9	11	9	8	0	0.868	1.000
442	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(4), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2)	3976029	12	9	13	9	5	1	2	1	3	0	0.870	1.000
443	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	30	AKT1(1), APC(7), ASAH1(1), CCL13(1), CCL15(1), DAG1(2), GNA11(2), GNA15(4), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), MAPK14(1), PHKA2(4), PIK3CD(2), SRC(2)	18006951	68	31	68	19	22	12	14	14	6	0	0.870	1.000
444	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(1), ACTA2(2), ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF2(1), ATF4(1), ATP2A2(2), ATP2A3(4), CACNB3(1), CALCA(3), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CNN2(1), CORIN(5), CREB3(1), CRHR1(2), DGKZ(5), FOS(1), GABPA(1), GJA1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), GSTO1(3), GUCA2B(1), GUCY1A3(5), IGFBP1(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(7), ITPR2(11), ITPR3(11), MIB1(2), MYL2(2), MYLK2(1), NFKB1(1), NOS1(9), NOS3(5), OXTR(2), PDE4B(1), PDE4D(3), PLCB3(5), PLCD1(1), PLCG1(3), PLCG2(11), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RAMP3(2), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SP1(6), TNXB(6), USP5(5), YWHAB(1)	64122809	255	100	250	85	106	32	48	38	31	0	0.871	1.000
445	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25B(1), CDKN1A(1), NEK1(2)	2383928	4	4	4	1	0	1	2	1	0	0	0.874	1.000
446	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), LCT(8), NAGLU(1)	5692197	17	10	17	7	7	0	3	3	4	0	0.874	1.000
447	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(7), ASAH1(1), CAV3(1), DAG1(2), DLG4(2), EPHB2(6), GNAQ(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), RHO(1), RYR1(14)	18204668	74	32	74	23	30	13	13	13	5	0	0.877	1.000
448	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(1), AKT2(1), AKT3(1), ASAH1(1), DAG1(2), DRD2(1), EPHB2(6), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), PIK3CB(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), SOS1(1), SOS2(4), SRC(2), STAT3(2), TERF2IP(3)	21593417	82	35	81	19	27	20	16	9	9	1	0.880	1.000
449	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX15(2), ALOX15B(1), ALOX5(1), DPEP1(3), GGT1(2), LTA4H(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3)	5728358	19	10	19	7	8	4	1	2	4	0	0.881	1.000
450	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	53	BMP5(3), BMP6(3), BTRC(1), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(2), GLI1(4), GLI2(8), GLI3(3), GSK3B(1), HHIP(4), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(2), SHH(2), SMO(2), STK36(2), SUFU(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4), ZIC2(1)	19604888	76	35	75	40	23	20	15	9	9	0	0.881	1.000
451	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA1(1), ACADM(2), ACADS(4), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	17450125	52	28	51	14	20	7	10	7	8	0	0.882	1.000
452	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	23	AKT1(1), APC(7), AXIN1(2), CD14(2), FZD1(1), GJA1(1), GSK3B(1), IRAK1(2), LBP(2), LEF1(1), LY96(1), NFKB1(1), PPP2CA(1), TLR4(1)	10180160	24	17	24	11	7	4	5	4	4	0	0.886	1.000
453	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1), OXCT1(1)	1377947	2	2	2	0	0	0	1	1	0	0	0.887	1.000
454	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), SNCAIP(2), UBE2E2(2), UBE2L3(1)	2567484	8	4	8	2	2	0	2	2	2	0	0.888	1.000
455	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1)	5466314	11	8	11	6	2	2	2	3	2	0	0.890	1.000
456	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(1), CD28(1), DAG1(2), EPHB2(6), FBXW7(2), GRAP2(1), ITK(3), ITPKB(2), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLCG1(3), PTPRC(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(1), SOS2(4), VAV1(6), ZAP70(5)	21037100	70	35	70	25	24	9	13	14	10	0	0.891	1.000
457	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT5(2), FUT6(2), ST3GAL3(1)	1913974	8	3	8	5	5	1	1	1	0	0	0.896	1.000
458	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), GH1(1), GHR(3), IGF1R(2), SOD3(1)	3770785	8	7	8	4	3	3	1	1	0	0	0.896	1.000
459	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), FTCD(3), GART(3), MTFMT(1), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1)	7607519	21	12	21	9	5	4	5	3	4	0	0.897	1.000
460	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), GZMB(3), MAP3K1(5), MAP3K14(2), MDM2(1), NFKB1(1), NFKBIA(2), PARP1(3), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(5), TRAF1(1), TRAF2(2)	14497999	41	26	41	17	8	5	13	8	7	0	0.897	1.000
461	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), AGT(3), AGTR2(1), EDNRA(1), EDNRB(1), EGF(3), FOS(1), NFKB1(1), PLCG1(3), PRKCA(3)	7219548	18	12	18	13	3	3	3	7	2	0	0.899	1.000
462	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST12(1), CHST13(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4)	3705994	11	6	11	5	4	1	2	3	1	0	0.901	1.000
463	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(4), BAG4(1), CASP2(1), CRADD(1), DFFA(1), DFFB(3), LMNB1(1), LMNB2(3), MADD(6), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TRAF2(2)	14743687	46	26	47	12	9	10	10	11	6	0	0.902	1.000
464	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), PER1(3)	3359241	10	5	10	4	2	1	3	1	3	0	0.902	1.000
465	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(1), ATM(7), ATR(9), BAI1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(3), DDB2(1), GADD45B(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(2), PERP(3), PPM1D(1), RFWD2(2), RPRM(1), SERPINB5(2), SERPINE1(1), SESN1(2), SESN2(1), SESN3(3), STEAP3(2), THBS1(3), TP53I3(2), TP73(1), TSC2(2)	24296544	62	36	64	27	13	17	12	9	10	1	0.904	1.000
466	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), PAK1(2)	3001382	7	4	7	1	1	1	1	1	3	0	0.906	1.000
467	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(1), ABL2(1), AKT1(1), AKT2(1), AKT3(1), ARAF(1), AREG(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CBL(1), CBLB(1), CBLC(1), CDKN1A(1), CDKN1B(3), EGF(3), ELK1(1), ERBB2(7), ERBB3(4), ERBB4(1), GAB1(1), GSK3B(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK9(2), NRAS(1), NRG1(4), NRG2(1), NRG3(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SRC(2), STAT5A(2), STAT5B(2), TGFA(2)	37720762	123	61	121	45	46	14	22	26	15	0	0.906	1.000
468	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(4), CASP6(1), DAXX(4), DFFA(1), DFFB(3), FAF1(3), LMNB1(1), LMNB2(3), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), PTPN13(4), RIPK2(1), SPTAN1(6)	15563846	45	25	46	11	5	10	10	13	7	0	0.907	1.000
469	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(1), RANGAP1(1)	3294692	3	3	3	2	1	0	1	1	0	0	0.907	1.000
470	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(3), OAT(1), PRODH(1)	2059879	6	3	6	1	2	0	1	1	2	0	0.907	1.000
471	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(5), ATP4A(5), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA3(1), NDUFA4(2), NDUFA4L2(1), NDUFA8(1), NDUFB1(1), NDUFB7(1), NDUFS2(1), NDUFS4(1), NDUFS7(1), NDUFV1(2), NDUFV2(2), PPA1(1), PPA2(1), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRQ(2)	22312708	77	37	78	25	23	16	20	10	8	0	0.908	1.000
472	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(1), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), F2(1), GNA11(2), GNB1(1), GNGT1(1), JAK2(4), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK14(1), MAPK3(2), MAPT(1), MYLK(7), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), SYT1(1)	16725683	50	29	49	20	15	6	11	14	4	0	0.909	1.000
473	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), ATM(7), BCL2(3), CCNE1(1), CDKN1A(1), MDM2(1), PCNA(1), TIMP3(2)	6307728	17	10	17	2	3	5	4	3	2	0	0.909	1.000
474	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1B10(2), AKR1C4(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), RDH13(1), SOAT1(2), SOAT2(2)	12781541	37	20	37	9	17	7	8	5	0	0	0.909	1.000
475	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(3), IRS1(4), MAPK1(3), MAPK14(1), MAPK3(2), MKNK1(1), PRKCA(3), RPS6KB1(1)	9454304	30	15	30	6	9	2	5	10	4	0	0.910	1.000
476	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TRAF2(2)	9608353	26	17	26	16	6	3	5	7	5	0	0.912	1.000
477	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2)	1481400	2	2	2	4	2	0	0	0	0	0	0.914	1.000
478	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	9	ATM(7), CDC25B(1), MYT1(7)	5677758	15	9	15	1	5	3	2	2	3	0	0.915	1.000
479	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(1), UQCRC1(3)	2672895	4	4	4	4	0	2	0	1	1	0	0.915	1.000
480	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	3	PLCD1(1), PRKCA(3)	1488258	4	2	4	2	1	0	2	1	0	0	0.915	1.000
481	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(3)	3347164	10	4	10	5	2	1	2	3	1	1	0.916	1.000
482	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(3), ACVR1C(2), ACVR2B(1), ACVRL1(2), AMHR2(3), BMP5(3), BMP6(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CDKN2B(1), COMP(1), CREBBP(8), CUL1(5), DCN(2), EP300(5), FST(2), GDF5(2), GDF6(1), GDF7(1), ID1(1), IFNG(1), INHBA(3), INHBB(2), INHBE(1), LEFTY2(2), LTBP1(1), MAPK1(3), MAPK3(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(3), RBL2(1), RHOA(1), ROCK1(3), ROCK2(4), RPS6KB1(1), SMAD3(1), SMAD4(1), SMAD7(1), SMAD9(1), SMURF1(6), SP1(6), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), THBS1(3), THBS2(5), THBS3(1), THBS4(2), ZFYVE16(2), ZFYVE9(2)	38799259	126	58	126	35	32	24	30	21	18	1	0.917	1.000
483	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(9), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), AKT1(1), AKT2(1), AKT3(1), CAMKK1(3), CAMKK2(1), CD36(2), CHUK(4), CPT1A(1), CPT1C(2), CPT2(1), G6PC(2), IKBKB(2), IRS1(4), IRS4(3), JAK1(3), JAK2(4), JAK3(4), LEPR(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK1(4), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKCQ(1), PTPN11(6), RXRA(3), RXRB(1), RXRG(1), SLC2A1(4), SLC2A4(3), STAT3(2), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2), TYK2(3)	32767225	117	54	113	39	42	14	23	19	19	0	0.918	1.000
484	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	A4GALT(4), ABO(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(4), B4GALT2(1), B4GALT4(1), B4GALT6(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2), ST3GAL1(2), ST3GAL3(1), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1)	18987660	70	33	71	19	22	8	21	14	5	0	0.920	1.000
485	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(2), CDT1(1), DIAPH2(3), MCM10(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), NACA(7), PCNA(1), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), PRIM1(1), RFC1(3), RFC2(1), RFC3(1), RFC4(2), RFC5(1), RPA4(2), UBA52(1), UBB(1), UBC(1)	20051853	55	32	52	22	15	3	15	5	17	0	0.921	1.000
486	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	13	ERCC3(2), GTF2B(2), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(1), NCOA3(4), NCOR2(5), POLR2A(2), RXRA(3), TBP(2)	9328188	27	15	28	7	7	2	9	2	7	0	0.924	1.000
487	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(2), DHRS7(1), PON1(4), PON3(2), RDH13(1)	3385089	10	5	10	3	4	1	3	2	0	0	0.926	1.000
488	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT2(1), B3GALT5(2), B3GNT5(1), FUT1(1), ST3GAL3(1)	2868757	8	4	8	6	4	1	2	1	0	0	0.926	1.000
489	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(2), ACO2(1), IDH2(2), MDH2(1), SUCLA2(1)	3264809	7	5	7	7	2	1	4	0	0	0	0.926	1.000
490	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCL2(3), BCR(1), FOS(1), JAK2(4), MAP2K1(1), MAP3K1(5), MAPK3(2), SOS1(1), STAT1(1), STAT5A(2), STAT5B(2)	9624492	24	15	23	6	8	5	5	3	3	0	0.929	1.000
491	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(5), NCOA1(3), NCOA2(1), RXRA(3)	7314514	20	11	21	5	3	4	7	2	3	1	0.930	1.000
492	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(2), OPRK1(1), POLR2A(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5009356	9	7	9	3	4	1	1	2	1	0	0.931	1.000
493	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2), RDH13(1)	1922363	5	3	5	0	4	0	1	0	0	0	0.931	1.000
494	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRA1D(1), ADRB1(1), ADRB2(1), ATP1A4(1), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1S(12), CACNB3(1), CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CASQ2(1), CHRM2(4), CHRM3(3), GJA1(1), GJB3(2), GJB5(2), GJB6(1), GNA11(2), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNB1(3), KCNJ3(2), KCNJ5(3), MIB1(2), NME7(3), PLCB3(5), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SLC8A3(2), USP5(5), YWHAB(1)	69976246	262	105	261	101	114	35	44	41	28	0	0.935	1.000
495	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(3)	2874536	8	3	8	7	2	1	1	3	0	1	0.936	1.000
496	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(3)	6221687	16	8	16	9	3	3	3	4	2	1	0.936	1.000
497	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC3(1), PSMD14(1), RPN1(1), UBE2A(1), UBE3A(4)	5186159	14	6	14	3	1	2	3	5	2	1	0.938	1.000
498	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(1), ATM(7), ATR(9), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), DHFR(1), GSK3B(1), HDAC1(1), TGFB1(1), TGFB2(1)	11044664	32	16	32	9	6	8	6	4	8	0	0.940	1.000
499	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(2), ACO2(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), PC(3), PCK1(4), SUCLA2(1), SUCLG1(2)	7900909	21	12	21	14	3	5	9	4	0	0	0.941	1.000
500	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(1), ALDOC(3)	1572725	7	2	7	1	3	2	1	1	0	0	0.941	1.000
501	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), CAPN1(5), CAPN10(2), CAPN11(1), CAPN2(1), CAPN3(2), CAPN5(1), CAPN6(5), CAPNS1(1), CAV1(1), CAV3(1), DOCK1(9), GIT2(2), ILK(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK6(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PIK3R2(5), PTK2(2), PXN(1), RAP1B(2), RHO(1), ROCK1(3), ROCK2(4), SEPP1(1), SHC3(1), SORBS1(2), SOS1(1), SRC(2), TLN1(6), TNS1(5), VASP(2), VAV2(3), VAV3(2), VCL(2), ZYX(2)	52505328	182	77	181	71	69	23	38	27	25	0	0.943	1.000
502	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), GNB1(1), GNGT1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3)	3641689	11	5	11	8	4	0	3	4	0	0	0.943	1.000
503	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(7), AXIN1(2), BTRC(1), FZD1(1), GSK3B(1), NOTCH1(4)	7699463	16	11	14	8	3	0	4	8	1	0	0.944	1.000
504	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(4), BTK(1), EEA1(2), GRASP(2), GSK3B(1), LYN(1), PFKM(3), PFKP(6), PLCG1(3), PRKCE(1), PRKCZ(2), RPS6KB1(1), VAV2(3)	9711807	33	15	33	11	9	8	4	5	7	0	0.945	1.000
505	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(8), CDR1(2), DGKI(3), FAU(1), PIGK(3), RPL10(1), RPL11(1), RPL14(1), RPL15(1), RPL18A(2), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL39(1), RPL5(2), RPL8(1), RPLP0(2), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), RPSA(1), TSPAN9(1), UBA52(1), UBB(1), UBC(1)	20666770	59	33	58	25	20	10	13	5	11	0	0.945	1.000
506	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF2S2(1), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1R(2), INPPL1(4), PPP2CA(1), RPS6KB1(1)	6051096	16	9	16	3	3	3	2	4	4	0	0.945	1.000
507	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(1), PRKCA(3), PTPRA(4), SRC(2)	3687886	10	5	10	2	4	1	2	1	2	0	0.946	1.000
508	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMB8(1)	3478665	7	4	7	1	1	1	1	3	1	0	0.948	1.000
509	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(1), FOS(1), IL2(1), IL2RA(3), IL2RB(1), JAK1(3), JAK3(4), MAP2K1(1), MAPK3(2), SOS1(1), STAT5A(2), STAT5B(2), SYK(2)	9381702	27	14	26	12	9	2	7	6	3	0	0.949	1.000
510	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(3), ELK1(1), FOS(1), MAP2K1(1), MAPK3(2), NGFR(1), PLCG1(3), SOS1(1)	6141192	13	8	13	5	5	2	2	2	2	0	0.949	1.000
511	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(1), AKT2(1), AKT3(1), BRD4(7), CBL(1), CDKN2A(3), FLOT1(2), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), LNPEP(2), MAPK1(3), MAPK3(2), PARD3(2), PARD6A(1), PIK3CD(2), PPYR1(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SERPINB6(1), SLC2A4(3), SORBS1(2), SOS1(1), SOS2(4), YWHAB(1), YWHAE(2)	21316006	66	34	66	31	20	8	9	14	15	0	0.949	1.000
512	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(8), MPI(1), PYGL(1), PYGM(2), TREH(2)	5368237	14	8	14	9	8	1	2	2	1	0	0.951	1.000
513	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(1), BCL2(3), CASP8AP2(3), CES1(2)	3968535	9	5	9	0	2	1	3	1	2	0	0.951	1.000
514	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB3(1), CREB5(1), DUSP4(3), DUSP9(1), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NFKB1(1), RPS6KA2(2), RPS6KA3(5), SOS1(1), SOS2(4), TRAF3(3)	11251091	34	17	33	9	11	3	7	11	2	0	0.952	1.000
515	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2)	1933650	6	2	6	4	4	0	1	0	1	0	0.953	1.000
516	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(4), GLB1(1), HEXA(1), LCT(8), ST3GAL1(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1)	6634452	23	11	23	9	13	1	4	3	2	0	0.953	1.000
517	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(2)	2548853	6	3	6	1	0	2	1	3	0	0	0.954	1.000
518	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GGT1(2), SHMT2(1)	2166090	4	3	4	1	2	0	1	0	1	0	0.954	1.000
519	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	FOS(1), MAPK1(3), MAPK14(1), NFE2L2(1), PRKCA(3)	3445740	9	4	9	4	2	2	1	4	0	0	0.956	1.000
520	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(7), ATR(9), BRCA1(4), CDC25B(1), CDKN1A(1), CDKN2D(1), EP300(5), MDM2(1), MYT1(7), PRKDC(5)	16182349	41	23	42	9	10	8	10	6	6	1	0.957	1.000
521	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(1), ACTB(1), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	20095421	63	33	63	27	21	9	14	14	5	0	0.957	1.000
522	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(1), ACTB(1), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1)	20095421	63	33	63	27	21	9	14	14	5	0	0.957	1.000
523	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(8), ACACB(9), AKT1(1), AKT2(1), AKT3(1), ARAF(1), CALM1(1), CBL(1), CBLB(1), CBLC(1), ELK1(1), EXOC7(2), FASN(7), FBP1(2), FBP2(4), FLOT1(2), FOXO1(1), G6PC(2), GCK(2), GSK3B(1), GYS2(3), IKBKB(2), INPP5D(6), INSR(5), IRS1(4), IRS4(3), KRAS(1), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MAPK9(2), MKNK1(1), NRAS(1), PCK1(4), PCK2(1), PDE3A(1), PDE3B(4), PFKM(3), PFKP(6), PHKA1(3), PHKA2(4), PHKB(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R2(5), PIK3R5(2), PKLR(4), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3A(9), PPP1R3C(1), PPP1R3D(2), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(4), PYGB(4), PYGL(1), PYGM(2), RHOQ(3), RPS6KB1(1), SH2B2(3), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS4(2), SORBS1(2), SOS1(1), SOS2(4), SREBF1(2), TRIP10(4), TSC1(4), TSC2(2)	60122518	222	87	221	71	85	30	42	37	28	0	0.958	1.000
524	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(1), B4GALT7(1), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST3(1), CHST7(2), CHSY1(1), UST(2), XYLT1(3), XYLT2(1)	5485838	17	10	17	6	7	1	5	1	3	0	0.959	1.000
525	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG8(1), ALG9(1), B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), B4GALT7(1), C1GALT1C1(3), CHST1(2), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST2(3), CHST3(1), CHST6(1), CHST7(2), CHSY1(1), DDOST(2), DPAGT1(1), EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), FUT8(1), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), NDST1(2), NDST2(2), NDST3(2), NDST4(5), OGT(3), RPN1(1), ST3GAL1(2), ST3GAL3(1), ST6GAL1(4), ST6GALNAC1(2), UST(2), WBSCR17(7), XYLT1(3), XYLT2(1)	43749781	164	66	164	50	60	23	32	24	25	0	0.959	1.000
526	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(1), SOS1(1), SRC(2)	3530468	4	4	4	4	1	1	1	1	0	0	0.959	1.000
527	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(2), DOLPP1(1), DPAGT1(1), FUT8(1), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), RFT1(1), RPN1(1), ST6GAL1(4)	16795454	44	24	44	15	13	7	8	10	6	0	0.959	1.000
528	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(1), MAT1A(2), PAPSS2(1), SCLY(1), SEPHS1(1)	4922070	11	7	11	7	5	2	2	2	0	0	0.960	1.000
529	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(7), APC2(2), AXIN1(2), AXIN2(1), BTRC(1), CACYBP(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CCND2(1), CHD8(9), CREBBP(8), CSNK2A1(3), CTBP1(3), CTBP2(4), CUL1(5), CXXC4(2), DAAM1(1), DAAM2(1), DKK1(1), DKK2(3), DVL2(2), EP300(5), FBXW11(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NKD2(2), PLCB1(3), PLCB2(5), PLCB3(5), PLCB4(3), PORCN(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RHOA(1), ROCK1(3), ROCK2(4), RUVBL1(1), SENP2(2), SFRP1(2), SFRP5(1), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(1), TBL1Y(1), TCF7(3), TCF7L2(3), VANGL1(2), VANGL2(1), WIF1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4)	62353562	215	86	211	70	64	25	53	40	31	2	0.961	1.000
530	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), ROCK1(3), SRC(2), TLN1(6)	13637503	36	20	36	9	14	4	7	5	6	0	0.962	1.000
531	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	56	AANAT(1), ABP1(9), ACMSD(1), AFMID(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), CYP1A1(1), CYP1B1(4), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), HSD17B10(1), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), MAOB(1), NFX1(3), OGDH(1), OGDHL(5), PRMT7(2), PRMT8(1), TDO2(2), TPH1(3)	23868039	70	37	68	25	33	8	12	12	5	0	0.963	1.000
532	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(7), AXIN1(2), CREBBP(8), EP300(5), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), TRRAP(8)	12947179	35	20	35	17	10	4	13	4	3	1	0.963	1.000
533	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(4), EIF4B(3), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), FKBP1A(1), MKNK1(1), PPP2CA(1), RPS6KB1(1), TSC1(4), TSC2(2)	9098958	25	14	25	4	5	3	5	3	9	0	0.963	1.000
534	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(4), AKT1(1), ATM(7), CDKN1A(1), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MDM2(1), NFKBIB(1)	7719882	19	10	19	4	6	7	1	3	2	0	0.966	1.000
535	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(3), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2)	9471806	29	14	29	4	8	4	10	4	2	1	0.966	1.000
536	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(7), AXIN1(2), CCND2(1), DVL2(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LDLR(4), MAPK9(2), PLAU(2), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), RHOA(1), TCF7(3), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT4(3), WNT5A(1)	22842777	77	38	74	26	24	6	18	14	15	0	0.967	1.000
537	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(3), GSK3B(1)	4666550	8	5	8	2	1	1	1	2	3	0	0.968	1.000
538	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), BIRC5(1), BNIP3L(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GZMB(3), IKBKB(2), IRF2(1), IRF4(2), IRF6(6), MAP3K1(5), MDM2(1), NFKB1(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PLEKHG5(2), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFSF10(5), TP73(1), TRAF1(1), TRAF2(2), TRAF3(3)	21748899	71	32	72	32	15	11	18	17	10	0	0.968	1.000
539	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(2), ACO1(2), ACO2(1), CLYBL(3), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), OGDHL(5), PC(3), PCK1(4), PCK2(1), SUCLA2(1), SUCLG1(2)	11623506	33	17	33	17	8	6	12	6	1	0	0.968	1.000
540	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(1), ACTN1(1), ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGEF7(1), CAV1(1), CDKN2A(3), CSE1L(2), DOCK1(9), EPHB2(6), GRB7(1), GRLF1(4), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(5), MAPK9(2), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PKLR(4), PLCG1(3), PLCG2(11), PTK2(2), RALA(1), RHO(1), ROCK1(3), ROCK2(4), SOS1(1), SOS2(4), SRC(2), TERF2IP(3), TLN1(6), TLN2(5), VASP(2), ZYX(2)	46250205	160	67	160	56	58	24	31	28	19	0	0.969	1.000
541	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), BTRC(1), CDC20(2), CDC23(1), CDC27(3), CUL1(5), CUL2(4), CUL3(1), FBXW11(2), FBXW7(2), ITCH(1), SMURF1(6), TCEB2(1), UBE2E2(2), VHL(1), WWP2(2)	16014634	46	23	47	10	11	4	9	12	10	0	0.969	1.000
542	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), GART(3), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1)	7282297	17	10	17	9	4	4	5	1	3	0	0.969	1.000
543	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1)	5295093	9	7	9	4	4	0	3	1	1	0	0.970	1.000
544	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CYP2C9(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2)	12265492	30	18	30	10	7	5	6	6	6	0	0.971	1.000
545	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B10(2), ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), FUK(1), GMDS(1), GMPPA(1), HK2(3), HK3(4), LHPP(1), MPI(1), MTMR1(2), MTMR2(3), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1), RDH13(1)	14193703	48	21	47	6	21	6	9	10	2	0	0.972	1.000
546	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(3), FOS(1), HDAC2(3), HDAC5(4), NCOR2(5), RBL1(3), RBL2(1), SIN3A(2), SIN3B(6)	10170982	28	14	28	7	9	4	8	3	4	0	0.972	1.000
547	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), NPAS2(1), NR1D1(3), PER1(3), PER2(2), PER3(1)	6718626	17	10	16	8	5	2	3	4	3	0	0.972	1.000
548	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(1), ACADM(2), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), APOA2(1), APOA5(1), AQP7(2), CD36(2), CPT1A(1), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A11(3), CYP4A22(4), CYP8B1(2), EHHADH(2), FADS2(1), GK(1), GK2(2), HMGCS2(3), ILK(2), ME1(4), NR1H3(1), OLR1(3), PCK1(4), PCK2(1), PLTP(1), PPARA(1), RXRA(3), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A4(2), SLC27A6(4), SORBS1(2), UBC(1), UCP1(1)	25503182	83	39	82	30	23	11	14	18	17	0	0.973	1.000
549	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT2(1)	1612285	3	2	3	0	2	0	1	0	0	0	0.973	1.000
550	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTR(2)	7027617	22	11	22	9	9	6	2	3	2	0	0.975	1.000
551	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1)	6163897	14	8	14	7	3	2	2	4	3	0	0.975	1.000
552	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1)	6826923	11	8	11	7	2	2	2	3	2	0	0.977	1.000
553	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25B(1), SHH(2), XPO1(2)	3517835	7	3	7	0	0	2	3	2	0	0	0.978	1.000
554	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(2), ACO1(2), ACO2(1), ACSS2(2), IDH2(2), MDH2(1), SUCLA2(1)	5050395	11	7	11	7	4	1	5	1	0	0	0.979	1.000
555	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(1)	2926677	6	4	6	3	2	0	2	1	1	0	0.979	1.000
556	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF1D(4), EEF2(4), EEF2K(2), EIF2AK1(2), EIF2AK2(1), EIF2AK3(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G3(1), EIF5A(1), EIF5B(3), ETF1(1), GSPT2(1), KIAA0664(4), PABPC3(2)	17275881	45	23	44	13	10	5	7	17	6	0	0.980	1.000
557	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA1(1), ACTA2(2), ACTN3(1), ACTN4(4), DES(3), DMD(11), FAM48A(5), MYBPC1(2), MYBPC2(1), MYBPC3(3), MYH3(6), MYH6(5), MYH7(3), MYH8(8), MYL2(2), MYOM1(3), NEB(11), TNNI1(2), TNNT1(2), TNNT2(1), TPM1(1), TPM3(1), TPM4(1), VIM(1)	23852628	80	35	80	32	32	14	17	11	6	0	0.980	1.000
558	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(3), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), MPL(2), PLCG1(3), PRKCA(3), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), THPO(1)	10511170	28	14	27	7	12	4	6	4	2	0	0.980	1.000
559	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), DFFA(1), DFFB(3), DIABLO(1)	5274802	12	8	12	2	3	0	5	3	1	0	0.981	1.000
560	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2)	2219692	2	2	2	1	1	0	1	0	0	0	0.981	1.000
561	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), WASF1(1)	3282209	7	3	7	1	1	1	1	1	3	0	0.982	1.000
562	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(1), CDKN2A(3), MDM2(1), POLR1A(3), POLR1B(1), POLR1C(1), TBX2(1)	5445052	11	6	11	10	1	4	3	1	2	0	0.983	1.000
563	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2(3), BCL2A1(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CRADD(1), DAXX(4), DFFA(1), DFFB(3), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(4), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3)	17487405	45	25	45	16	10	7	12	11	5	0	0.983	1.000
564	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	APAF1(1), ARHGDIB(4), BAG4(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), CHUK(4), CRADD(1), DAXX(4), DFFA(1), DFFB(3), GSN(2), LMNB1(1), LMNB2(3), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(1), NFKBIA(2), NUMA1(4), PRKCD(5), PRKDC(5), PSEN2(1), PTK2(2), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2)	26678168	76	39	76	25	15	11	22	16	12	0	0.984	1.000
565	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), MAP2(3), PPP2CA(1), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1), PRKCE(1)	7405607	14	8	14	9	2	5	2	3	2	0	0.985	1.000
566	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(1), AKT2(1), AKT3(1), ARHGEF11(3), BCL2(3), DLG4(2), LPA(6), MAP3K1(5), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PHKA2(4), PIK3CB(2), PLD2(1), PTK2(2), ROCK1(3), ROCK2(4), SRF(2)	18693986	48	26	48	17	15	9	10	6	8	0	0.985	1.000
567	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB3(1), CREB5(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(1), IL1R1(2), MAP2K3(1), MAP3K10(3), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), NFKB1(1), SRF(2)	13300265	30	18	30	9	10	4	1	11	4	0	0.986	1.000
568	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), GPI(4), PKLR(4)	3384490	9	4	9	2	5	0	1	1	2	0	0.986	1.000
569	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), FN3K(1), HADHA(1), ITGB1BP3(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2)	10227781	23	13	23	7	4	5	3	5	6	0	0.987	1.000
570	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(1), CHUK(4), DAXX(4), ELK1(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(1), NFKBIA(2), PAK1(2), RIPK1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SP1(6), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2)	37099530	107	51	106	38	32	12	15	27	21	0	0.987	1.000
571	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATM(7), ATR(9), BRCA1(4), BRCA2(7), FANCA(4), FANCC(2), FANCD2(4), FANCG(1), MRE11A(3), RAD1(1), RAD17(2), RAD50(2), RAD9A(1)	17216522	47	20	47	8	11	8	6	13	8	1	0.987	1.000
572	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(3), APC(7), ATF2(1), AXIN1(2), BMP10(2), BMP5(3), BMPR1A(2), BMPR2(2), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(2), MEF2C(1), MYL2(2), RFC1(3), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2)	14155219	44	18	44	13	9	6	13	10	6	0	0.987	1.000
573	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	15	CARM1(1), LCMT1(1), PCYT1A(1), PCYT1B(2), PRMT7(2), PRMT8(1)	5326483	8	6	8	5	3	0	3	1	1	0	0.987	1.000
574	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2)	6448451	14	8	14	4	2	2	3	3	4	0	0.988	1.000
575	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHFR(1), DHX58(2), EP400(15), ERCC2(1), ERCC3(2), FPGS(2), IFIH1(2), MOV10L1(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SKIV2L2(1), SMARCA2(5), SMARCA5(2)	24991247	79	37	79	26	25	13	18	14	9	0	0.989	1.000
576	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLG(4), POLH(2), POLI(2), POLK(1), POLL(2), POLM(1), POLQ(7), PRIM1(1), REV1(1), REV3L(6), RFC5(1)	16146761	46	19	45	16	11	7	15	7	5	1	0.989	1.000
577	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1), PDK3(1), PDK4(2), PDP2(1), SUCLA2(1), SUCLG1(2)	11406070	26	14	26	17	7	6	7	4	2	0	0.989	1.000
578	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), BIRC2(1), BIRC3(1), MAP3K3(4), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), RALBP1(3), RIPK1(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	10020470	27	12	27	13	9	3	5	7	3	0	0.990	1.000
579	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	35	CCNH(2), ERCC3(2), GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(2), POLR1A(3), POLR1B(1), POLR2A(2), POLR2B(4), POLR3B(4), POLR3D(1), TAF5(2), TAF6(3), TAF7(2), TAF9(1), TBP(2)	14056316	36	17	35	6	7	5	13	5	6	0	0.990	1.000
580	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ITPA(1), NUDT2(1), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), RRM1(2), TK2(1), TXNRD1(1), UPB1(1), UPP1(2)	22781723	58	30	57	26	15	9	19	7	7	1	0.990	1.000
581	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(1), GNAS(3), GNB1(1), GNGT1(1), IGF1R(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NGFR(1), PPP2CA(1), PTPRR(2), SOS1(1), SRC(2), STAT3(2)	11268813	25	16	25	10	12	5	3	4	1	0	0.990	1.000
582	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(7), CCNA1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F2(3), E2F3(2), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MYT1(7), NACA(7), PCNA(1), POLA2(3), POLE(4), POLE2(2), PRIM1(1), RBL1(3), TFDP2(1), TNXB(6)	28571523	82	38	79	28	26	13	19	9	15	0	0.991	1.000
583	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AICDA(3), CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ENTPD3(1), ITPA(1), NME7(3), NT5C1B(3), NT5C2(2), NUDT2(1), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), TXNRD2(3), UPB1(1), UPP1(2), UPP2(1), ZNRD1(1)	32129500	89	44	89	36	28	12	26	11	12	0	0.992	1.000
584	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), ZNRD1(1)	9520788	23	12	23	3	8	4	5	3	3	0	0.993	1.000
585	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(1), CBX3(1), CLDN5(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), EIF4G2(2), GFRA1(1), GSTM3(1), GSTP1(1), HERPUD1(1), KLF9(1), NCKAP1(2), PER1(3), PER2(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(2), TUBB3(1), UCP3(2), UGP2(1), ZFR(1)	13941857	36	17	36	11	10	2	12	5	7	0	0.993	1.000
586	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS2(3), EARS2(2), EPRS(2), FARSA(1), FARSB(1), HARS(3), HARS2(1), IARS(4), IARS2(1), KARS(4), LARS(3), LARS2(1), MARS(1), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(1), VARS(3), VARS2(5), YARS(2), YARS2(2)	21945440	59	29	58	22	16	9	13	13	8	0	0.993	1.000
587	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GAS2(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(2), TNFRSF25(1), TNFSF10(5), TRAF2(2)	13210098	38	19	38	13	8	1	14	11	4	0	0.994	1.000
588	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(1), AKT2(1), AKT3(1), CDKN1B(3), CDKN2A(3), CREB3(1), CREB5(1), ERBB4(1), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), MET(5), NOLC1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARD3(2), PARD6A(1), PIK3CD(2), PREX1(9), PTK2(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SLC2A4(3), SOS1(1), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAE(2)	28824124	82	38	82	26	25	9	13	16	19	0	0.995	1.000
589	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), NRG2(1), NRG3(1), PRKCA(3)	3608656	6	3	6	4	3	0	1	1	1	0	0.995	1.000
590	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), ARPC4(1), DIAPH1(2), GSN(2), LIMK1(1), MYL2(2), MYLK(7), OPHN1(1), PIP5K1B(2), PPP1R12B(6), ROCK1(3), SRC(2), TLN1(6), VCL(2)	18138147	52	23	52	15	21	7	8	6	10	0	0.997	1.000
591	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	ADRBK1(2), AKT1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PHKA2(4), PIK3CB(2), PLD2(1), VN1R1(1)	16789819	54	22	54	12	17	9	9	9	10	0	0.997	1.000
592	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(2), GBF1(5), GPLD1(2), KDELR1(1), KDELR2(1)	6465040	15	6	15	6	5	2	3	4	0	1	0.997	1.000
593	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	1626459	1	1	1	0	0	0	0	1	0	0	0.997	1.000
594	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), AK1(1), ALLC(3), AMPD1(7), AMPD3(4), ATIC(1), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NPR2(1), NUDT2(1), PAPSS2(1), PDE1A(1), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6B(7), PDE6C(1), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(5), PKLR(4), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(7), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2)	50384760	143	66	138	54	58	14	31	18	21	1	0.998	1.000
595	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN3(1), CTNNA1(1), CTNNA2(2), PECAM1(2), PTK2(2), PXN(1), SRC(2), VCL(2)	7930015	14	9	14	6	5	2	3	2	2	0	0.998	1.000
596	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN3(1), CAPN1(5), CAPNS1(1), ITGA1(1), ITGB3(1), PTK2(2), PXN(1), SPTAN1(6), SRC(2), TLN1(6)	11191079	28	13	28	10	13	2	4	7	2	0	0.998	1.000
597	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ASH1L(3), CASK(2), CGN(3), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CRB3(1), CSDA(1), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41(2), EPB41L1(2), EPB41L2(2), EPB41L3(7), EXOC3(3), EXOC4(1), F11R(1), GNAI2(1), HCLS1(5), INADL(3), JAM2(1), JAM3(1), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(2), MLLT4(5), MPDZ(5), MPP5(1), MYH1(3), MYH10(3), MYH11(7), MYH13(11), MYH14(6), MYH15(3), MYH3(6), MYH4(6), MYH6(5), MYH7(3), MYH7B(9), MYH8(8), MYH9(8), MYL2(2), MYLPF(1), NRAS(1), OCLN(1), PARD3(2), PARD6A(1), PARD6B(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(3), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), RHOA(1), RRAS2(3), SPTAN1(6), SRC(2), SYMPK(4), TJAP1(5), TJP1(2), TJP2(3), TJP3(6), ZAK(1)	74347867	243	95	239	103	101	31	46	36	29	0	0.998	1.000
598	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), IDH2(2), OGDH(1), SUCLA2(1)	3806392	5	3	5	9	2	1	2	0	0	0	0.998	1.000
599	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(1), APAF1(1), ATM(7), BCL2(3), CASP6(1), PRKCA(3), PTK2(2), PXN(1), STAT1(1), TLN1(6)	10587692	26	12	26	4	8	4	5	6	3	0	0.998	1.000
600	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC2(1), PSMC3(1), PSMD11(1), PSMD12(3)	6453136	12	5	12	3	1	1	2	4	4	0	0.998	1.000
601	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN3(1), BCR(1), CAPN1(5), CAPNS1(1), CAV1(1), ITGA1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), PPP1R12B(6), PTK2(2), PXN(1), ROCK1(3), SOS1(1), SRC(2), TLN1(6), VCL(2), ZYX(2)	18381154	44	22	44	14	16	6	6	11	5	0	0.998	1.000
602	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), DRD1(2), DRD2(1), GRM1(1), PLCB1(3), PPP2CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6247312	12	5	12	11	4	2	1	3	1	1	0.998	1.000
603	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(1), ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ATM(7), ATR(9), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDC20(2), CDC23(1), CDC25B(1), CDC27(3), CDC7(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREBBP(8), CUL1(5), E2F2(3), E2F3(2), EP300(5), ESPL1(8), GADD45B(1), GSK3B(1), HDAC1(1), HDAC2(3), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(5), PTTG2(2), RBL1(3), RBL2(1), SMAD3(1), SMAD4(1), SMC1A(7), SMC1B(3), TGFB1(1), TGFB2(1), YWHAB(1), YWHAE(2)	52835399	142	61	142	40	28	29	39	17	28	1	0.998	1.000
604	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(1), ATM(7), BRCA1(4), CDKN1A(1), MDM2(1), MRE11A(3), NFKB1(1), NFKBIA(2), RAD50(2), RBBP8(2), TP73(1)	11257255	25	12	26	8	5	8	3	6	3	0	0.998	1.000
605	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(1), ATM(7), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(5), CDC20(2), CDC25B(1), CDC7(2), CDH1(3), CDKN1A(1), CDKN2A(3), E2F2(3), E2F3(2), EP300(5), ESPL1(8), GSK3B(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), HDAC8(1), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MPL(2), PCNA(1), PLK1(1), PRKDC(5), PTPRA(4), PTTG2(2), RBL1(3), SMAD4(1), TBC1D8(4), TGFB1(1)	42619691	109	51	109	39	26	22	30	12	18	1	0.998	1.000
606	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), EPRS(2), HARS(3), IARS(4), KARS(4), LARS(3), LARS2(1), MARS(1), NARS(1), QARS(3), TARS(2), YARS(2)	13075913	29	14	29	11	8	6	5	5	5	0	0.999	1.000
607	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), PLOD1(2), PLOD3(1), SDS(4), SHMT2(1), TMLHE(1)	14665322	40	17	40	9	7	12	9	6	6	0	0.999	1.000
608	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1)	1723510	2	1	2	0	1	0	0	1	0	0	0.999	1.000
609	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), ACVR1C(2), CDH1(3), CREBBP(8), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), EP300(5), ERBB2(7), FARP2(2), FGFR1(3), IGF1R(2), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(3), MAPK3(2), MET(5), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(4), PTPRF(4), PTPRJ(2), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(5), RHOA(1), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(2), SSX2IP(1), TCF7(3), TCF7L2(3), TGFBR1(1), TGFBR2(5), TJP1(2), VCL(2), WASF1(1), WASF2(1)	46520680	129	59	125	38	41	22	29	21	14	2	0.999	1.000
610	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	53	ASH1L(3), ASH2L(1), CARM1(1), CTCFL(3), EED(2), EHMT1(3), EHMT2(2), EZH1(2), EZH2(2), FBXO11(3), HCFC1(3), HSF4(1), JMJD4(2), KDM6A(2), MEN1(2), MLL(3), MLL2(7), MLL3(12), MLL4(7), MLL5(3), NSD1(7), OGT(3), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(9), SETD7(2), SETD8(1), SETDB2(3), SMYD3(1), SUV39H2(3), SUV420H1(1), SUV420H2(3), SUZ12(1), WHSC1(4), WHSC1L1(7)	45951361	121	53	120	38	25	20	31	21	24	0	0.999	1.000
611	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(2), LCMT1(1), MARS(1), MAT1A(2), PAPSS2(1), PRMT7(2), PRMT8(1), SCLY(1), SEPHS1(1)	9615700	16	10	16	12	8	2	3	3	0	0	0.999	1.000
612	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), DHRS7(1), LCMT1(1), PRMT7(2), PRMT8(1)	5440284	6	4	6	7	3	0	2	1	0	0	1.000	1.000
613	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADSSL1(1), AK1(1), AK7(2), ALLC(3), AMPD1(7), AMPD3(4), ATIC(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), ENTPD3(1), GART(3), GMPR(1), GMPR2(1), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NME7(3), NPR2(1), NT5C1B(3), NT5C2(2), NUDT2(1), PAPSS2(1), PDE11A(2), PDE1A(1), PDE1C(4), PDE2A(3), PDE3B(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6D(1), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(1), RRM1(2), XDH(8), ZNRD1(1)	64495867	190	77	187	68	70	28	42	21	29	0	1.000	1.000
614	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), AKAP10(4), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(2), AKAP5(2), AKAP6(5), AKAP7(1), AKAP8(3), AKAP9(4), ARHGEF1(2), CALM1(1), GNA11(2), GNA12(2), GNA15(4), GNAI2(1), GNAL(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNGT1(1), GNGT2(1), ITPR1(7), KCNJ3(2), KRAS(1), NRAS(1), PDE1A(1), PDE1C(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PLCB3(5), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), PRKD3(6), RHOA(1), SLC9A1(3), USP5(5)	46657373	152	58	151	47	51	24	33	24	20	0	1.000	1.000
615	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), HSD17B10(1), HSD17B4(1), NSD1(7), OGDH(1), OGDHL(5), PIPOX(2), PLOD1(2), PLOD3(1), RDH13(1), SETD1A(1), SETD7(2), SHMT2(1), SUV39H2(3), TMLHE(1)	23173273	53	23	53	14	17	8	14	8	6	0	1.000	1.000
616	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CLK2(2), CLK4(2), COL2A1(2), CPSF1(4), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDIT3(1), DHX15(1), DHX16(4), DHX38(4), DHX8(4), DHX9(2), DICER1(4), FUS(1), GIPC1(2), NCBP2(1), NONO(3), NUDT21(2), NXF1(1), PABPN1(2), PHF5A(1), POLR2A(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(9), PSKH1(1), PTBP1(2), PTBP2(1), RBM17(1), RNGTT(1), SF3A1(2), SF3A3(2), SF3B1(2), SF3B2(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SRPK1(2), SRPK2(3), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF2(2), XRN2(2)	41964994	94	40	97	19	28	9	22	14	21	0	1.000	1.000
