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MAF used for this analysis:GBM.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 89
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 89. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| PTEN | 44436 | 0 | 0 | 80 | 35 | 0 | 0 |
| POTEB | 5244 | 0 | 1 | 9 | 0 | 4.1e-212 | 3.9e-208 |
| TP53 | 34776 | 0 | 1 | 91 | 28 | 2.2e-91 | 1.4e-87 |
| IDH1 | 44160 | 0 | 0 | 15 | 0 | 3.6e-83 | 1.7e-79 |
| KRTAP5-5 | 16008 | 0 | 0 | 18 | 14 | 1.3e-73 | 4.8e-70 |
| RB1 | 134412 | 0 | 1 | 21 | 18 | 7.6e-56 | 2.4e-52 |
| MICALCL | 57408 | 0 | 0 | 13 | 12 | 3.5e-44 | 9.5e-41 |
| PIK3CA | 116196 | 0 | 1 | 19 | 2 | 4.3e-32 | 1e-28 |
| FOXRED1 | 44160 | 0 | 0 | 9 | 0 | 5e-30 | 1e-26 |
| EGFR | 126132 | 0 | 5 | 58 | 0 | 8.6e-29 | 1.6e-25 |
| NF1 | 412068 | 0 | 1 | 34 | 20 | 3.2e-26 | 5.6e-23 |
| IRF5 | 41400 | 0 | 0 | 5 | 5 | 6.9e-22 | 1.1e-18 |
| CALN1 | 24012 | 0 | 1 | 9 | 0 | 4.5e-20 | 6.5e-17 |
| ZNF704 | 36984 | 0 | 0 | 5 | 5 | 4.8e-18 | 6.4e-15 |
| PRMT6 | 24288 | 0 | 0 | 5 | 0 | 1.4e-17 | 1.8e-14 |
| COMMD4 | 16008 | 0 | 0 | 6 | 0 | 4.3e-17 | 5e-14 |
| NKPD1 | 12144 | 0 | 0 | 4 | 4 | 1.2e-16 | 1.3e-13 |
| POTED | 13800 | 0 | 1 | 5 | 1 | 1.3e-16 | 1.3e-13 |
| TGM2 | 59064 | 0 | 2 | 9 | 2 | 6.7e-15 | 6.6e-12 |
| ARHGEF2 | 80592 | 0 | 0 | 6 | 1 | 1.1e-14 | 1e-11 |
| NACA | 134136 | 0 | 0 | 7 | 6 | 2.3e-11 | 2e-08 |
| PIK3R1 | 81420 | 0 | 0 | 17 | 8 | 3e-11 | 2.6e-08 |
| LPHN1 | 114816 | 0 | 2 | 10 | 0 | 1.8e-10 | 1.5e-07 |
| STAG2 | 137172 | 0 | 0 | 11 | 7 | 5.6e-10 | 4.4e-07 |
| PLA2G2A | 14904 | 0 | 0 | 5 | 0 | 2.2e-09 | 1.7e-06 |
| EML2 | 56304 | 0 | 1 | 8 | 8 | 3.3e-09 | 2.4e-06 |
| IGSF9 | 73140 | 0 | 0 | 7 | 2 | 2e-08 | 0.000014 |
| MST1 | 58236 | 0 | 0 | 10 | 7 | 2.3e-08 | 0.000016 |
| PRIM2 | 46644 | 0 | 1 | 5 | 5 | 2.9e-08 | 0.000019 |
| PROKR2 | 40296 | 0 | 1 | 6 | 0 | 3.6e-08 | 0.000022 |
| TMEM45A | 29808 | 0 | 0 | 5 | 0 | 7e-08 | 0.000043 |
| EPX | 64584 | 0 | 2 | 6 | 1 | 2.5e-07 | 0.00015 |
| BBS1 | 52992 | 0 | 0 | 8 | 6 | 2.6e-07 | 0.00015 |
| ZFP42 | 30084 | 0 | 4 | 8 | 0 | 2.7e-07 | 0.00015 |
| SEMG1 | 46092 | 0 | 0 | 8 | 0 | 2.9e-07 | 0.00016 |
