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MAF used for this analysis:STAD.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 14
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 14. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| TP53 | 16758 | 4 | 2 | 68 | 22 | 1.5e-62 | 2.9e-58 |
| KRAS | 13760 | 4 | 0 | 17 | 0 | 1e-52 | 9.6e-49 |
| CBWD1 | 15184 | 4 | 0 | 18 | 16 | 1.5e-45 | 9.7e-42 |
| RPL22 | 6650 | 1 | 0 | 10 | 10 | 5.5e-38 | 2.6e-34 |
| ARID1A | 77406 | 6 | 2 | 30 | 20 | 1.4e-18 | 5.4e-15 |
| RNF43 | 26672 | 4 | 2 | 16 | 11 | 1.7e-13 | 5.4e-10 |
| ACVR2A | 25259 | 7 | 0 | 18 | 14 | 9e-13 | 2.4e-09 |
| PIK3CA | 56115 | 14 | 3 | 33 | 1 | 1.8e-10 | 4.2e-07 |
| PHF2 | 37894 | 10 | 4 | 14 | 10 | 1.6e-08 | 0.000033 |
| PGM5 | 20831 | 8 | 0 | 21 | 2 | 1.1e-07 | 0.00021 |
| UPF3A | 16021 | 6 | 1 | 7 | 6 | 2.9e-07 | 0.00049 |
| HLA-B | 12707 | 9 | 0 | 13 | 7 | 1.3e-06 | 0.0021 |
| MLL2 | 164919 | 6 | 8 | 34 | 12 | 8.9e-06 | 0.013 |
| MLL4 | 65258 | 4 | 3 | 25 | 9 | 0.000063 | 0.084 |
| CRYGC | 7980 | 0 | 0 | 6 | 0 | 0.0001 | 0.13 |
| RHOA | 12768 | 8 | 0 | 8 | 0 | 0.00086 | 1 |
| FAM9A | 11693 | 1 | 0 | 7 | 5 | 0.00097 | 1 |
| ERBB3 | 58659 | 6 | 3 | 21 | 0 | 0.0014 | 1 |
| SPERT | 14159 | 1 | 3 | 8 | 2 | 0.0016 | 1 |
| HLA-A | 14303 | 1 | 1 | 9 | 2 | 0.0024 | 1 |
| SMAD2 | 21934 | 8 | 0 | 8 | 5 | 0.0024 | 1 |
| OR8H3 | 16819 | 0 | 1 | 10 | 0 | 0.0025 | 1 |
| TPTE | 30651 | 24 | 3 | 17 | 1 | 0.0028 | 1 |
| NCOA2 | 63923 | 15 | 2 | 12 | 1 | 0.003 | 1 |
| CDC5L | 37772 | 7 | 0 | 10 | 0 | 0.0031 | 1 |
| HNF1A | 22682 | 3 | 1 | 6 | 5 | 0.0032 | 1 |
| BCOR | 65320 | 11 | 2 | 14 | 8 | 0.0036 | 1 |
| DOCK3 | 87088 | 28 | 6 | 26 | 10 | 0.0037 | 1 |
| IRF2 | 17229 | 3 | 1 | 11 | 3 | 0.0038 | 1 |
| TLR4 | 43092 | 0 | 2 | 13 | 0 | 0.004 | 1 |
| AKAP7 | 19878 | 10 | 0 | 6 | 5 | 0.0042 | 1 |
| MAP2K7 | 14226 | 4 | 0 | 13 | 2 | 0.0043 | 1 |
| FSHR | 36309 | 17 | 3 | 17 | 1 | 0.0045 | 1 |
| CAMTA2 | 50507 | 0 | 2 | 11 | 6 | 0.0048 | 1 |
| HIST1H1B | 9044 | 0 | 3 | 9 | 2 | 0.0049 | 1 |
