E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.151 -9999.0 0.0 -0.513 66.0 66.0 KLHL20 -0.029 0.063 -9999.0 0.0 -0.28 11.0 11.0 CYFIP2 -0.025 0.153 -9999.0 0.0 -0.626 50.0 50.0 Rac1/GDP 0.027 0.1 -9999.0 0.0 -0.488 2.0 2.0 ENAH -0.005 0.15 -9999.0 0.0 -0.51 66.0 66.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.011 0.033 -9999.0 0.0 -0.529 3.0 3.0 CDC42/GTP -0.021 0.066 -9999.0 0.0 -0.435 2.0 2.0 ABI1/Sra1/Nap1 -0.025 0.048 -9999.0 0.0 -0.211 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.016 0.137 -9999.0 0.0 -0.397 88.0 88.0 RAPGEF1 0.01 0.133 -9999.0 0.0 -0.434 66.0 66.0 CTNND1 0.012 0.023 -9999.0 0.0 -0.455 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.153 -9999.0 0.0 -0.531 66.0 66.0 CRK 0.002 0.143 -9999.0 0.0 -0.477 66.0 66.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.126 -9999.0 0.0 -0.43 68.0 68.0 alphaE/beta7 Integrin -0.002 0.098 -9999.0 0.0 -0.428 41.0 41.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.021 0.042 -9999.0 0.0 -0.389 8.0 8.0 DLG1 -0.005 0.149 -9999.0 0.0 -0.51 66.0 66.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.048 -9999.0 0.0 -0.301 2.0 2.0 MLLT4 0.006 0.07 -9999.0 0.0 -0.63 10.0 10.0 ARF6/GTP/NME1/Tiam1 0.016 0.056 -9999.0 0.0 -0.389 11.0 11.0 PI3K -0.02 0.062 -9999.0 0.0 -0.405 2.0 2.0 ARF6 0.013 0.016 -9999.0 0.0 -0.455 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.023 0.143 -9999.0 0.0 -0.498 69.0 69.0 TIAM1 0.002 0.084 -9999.0 0.0 -0.616 15.0 15.0 E-cadherin(dimer)/Ca2+ -0.004 0.108 -9999.0 0.0 -0.36 68.0 68.0 AKT1 -0.011 0.035 -9999.0 0.0 -0.214 2.0 2.0 PIK3R1 0.012 0.023 -9999.0 0.0 -0.455 2.0 2.0 CDH1 -0.04 0.184 -9999.0 0.0 -0.671 66.0 66.0 RhoA/GDP 0.027 0.1 -9999.0 0.0 -0.488 2.0 2.0 actin cytoskeleton organization 0.016 0.064 -9999.0 0.0 -0.208 9.0 9.0 CDC42/GDP 0.027 0.1 -9999.0 0.0 -0.488 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.002 0.089 -9999.0 0.0 -0.298 68.0 68.0 ITGB7 -0.016 0.131 -9999.0 0.0 -0.592 40.0 40.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.003 0.114 -9999.0 0.0 -0.381 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.01 0.107 -9999.0 0.0 -0.367 68.0 68.0 mol:GDP 0.02 0.115 -9999.0 0.0 -0.435 7.0 7.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.01 0.04 -9999.0 0.0 -0.565 4.0 4.0 p120 catenin/RhoA/GDP -0.024 0.086 -9999.0 0.0 -0.499 2.0 2.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.033 -9999.0 0.0 -0.674 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.003 0.077 -9999.0 0.0 -0.226 73.0 73.0 NME1 0.009 0.045 -9999.0 0.0 -0.455 8.0 8.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.152 -9999.0 0.0 -0.515 66.0 66.0 regulation of cell-cell adhesion -0.019 0.059 -9999.0 0.0 -0.372 2.0 2.0 WASF2 -0.013 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.024 0.076 -9999.0 0.0 -0.51 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.01 0.131 -9999.0 0.0 -0.682 4.0 4.0 CCND1 0.002 0.096 -9999.0 0.0 -0.284 73.0 73.0 VAV2 0.006 0.14 -9999.0 0.0 -0.555 7.0 7.0 RAP1/GDP 0.023 0.094 -9999.0 0.0 -0.506 2.0 2.0 adherens junction assembly -0.005 0.147 -9999.0 0.0 -0.497 66.0 66.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.003 0.129 -9999.0 0.0 -0.66 5.0 5.0 E-cadherin/beta catenin -0.034 0.115 -9999.0 0.0 -0.43 65.0 65.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.008 0.151 -9999.0 0.0 -0.515 66.0 66.0 PIK3CA 0.012 0.023 -9999.0 0.0 -0.455 2.0 2.0 Rac1/GTP -0.046 0.102 -9999.0 0.0 -0.455 14.0 14.0 E-cadherin/beta catenin/alpha catenin -0.012 0.123 -9999.0 0.0 -0.424 68.0 68.0 ITGAE 0.013 0.016 -9999.0 0.0 -0.455 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.045 0.147 -9999.0 0.0 -0.544 66.0 66.0