Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.001 0.091 -9999.0 0.0 -0.284 76.0 76.0 epithelial cell differentiation -0.03 0.098 -9999.0 0.0 -0.357 68.0 68.0 CYFIP2 -0.025 0.153 -9999.0 0.0 -0.626 50.0 50.0 ENAH 0.035 0.081 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.076 0.215 -9999.0 0.0 -0.571 129.0 129.0 EPHA2 0.003 0.075 -9999.0 0.0 -0.543 15.0 15.0 MYO6 0.005 0.104 -9999.0 0.0 -0.336 70.0 70.0 CTNNB1 0.011 0.033 -9999.0 0.0 -0.528 3.0 3.0 ABI1/Sra1/Nap1 0.002 0.099 -9999.0 0.0 -0.424 39.0 39.0 AQP5 -0.154 0.212 -9999.0 0.0 -0.537 173.0 173.0 CTNND1 0.012 0.023 -9999.0 0.0 -0.455 2.0 2.0 mol:PI-4-5-P2 0.006 0.101 -9999.0 0.0 -0.331 68.0 68.0 regulation of calcium-dependent cell-cell adhesion -0.014 0.121 -9999.0 0.0 -0.344 80.0 80.0 EGF -0.136 0.27 -9999.0 0.0 -0.61 201.0 201.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.103 0.187 -9999.0 0.0 -0.535 111.0 111.0 cortical microtubule organization -0.03 0.098 -9999.0 0.0 -0.357 68.0 68.0 GO:0000145 0.005 0.097 -9999.0 0.0 -0.316 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.108 -9999.0 0.0 -0.36 68.0 68.0 MLLT4 0.006 0.07 -9999.0 0.0 -0.63 10.0 10.0 ARF6/GDP -0.028 0.082 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.016 -9999.0 0.0 -0.455 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.052 -9999.0 0.0 -0.381 8.0 8.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.016 0.099 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.005 0.103 -9999.0 0.0 -0.336 68.0 68.0 ARF6/GTP -0.007 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.04 0.184 -9999.0 0.0 -0.671 66.0 66.0 EGFR/EGFR/EGF/EGF -0.135 0.177 -9999.0 0.0 -0.563 51.0 51.0 RhoA/GDP -0.028 0.091 -9999.0 0.0 -0.332 68.0 68.0 actin cytoskeleton organization 0.01 0.102 -9999.0 0.0 -0.49 1.0 1.0 IGF-1R heterotetramer -0.061 0.208 -9999.0 0.0 -0.634 96.0 96.0 GIT1 0.01 0.043 -9999.0 0.0 -0.492 6.0 6.0 IGF1R -0.061 0.208 -9999.0 0.0 -0.635 96.0 96.0 IGF1 -0.07 0.212 -9999.0 0.0 -0.592 115.0 115.0 DIAPH1 -0.032 0.135 -9999.0 0.0 -0.639 39.0 39.0 Wnt receptor signaling pathway 0.03 0.098 0.357 68.0 -9999.0 0.0 68.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.082 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.033 -9999.0 0.0 -0.674 2.0 2.0 VCL 0.01 0.104 -9999.0 0.0 -0.504 1.0 1.0 EFNA1 0.012 0.024 -9999.0 0.0 -0.674 1.0 1.0 LPP 0.01 0.102 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.032 0.094 -9999.0 0.0 -0.394 2.0 2.0 SEC6/SEC8 -0.028 0.086 -9999.0 0.0 -0.55 2.0 2.0 MGAT3 -0.014 0.123 -9999.0 0.0 -0.349 80.0 80.0 HGF/MET -0.085 0.16 -9999.0 0.0 -0.644 26.0 26.0 HGF -0.033 0.17 -9999.0 0.0 -0.655 58.0 58.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.001 0.091 -9999.0 0.0 -0.286 76.0 76.0 actin cable formation 0.046 0.082 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.01 0.107 -9999.0 0.0 -0.752 2.0 2.0 KIFC3 0.002 0.108 -9999.0 0.0 -0.336 76.0 76.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.005 0.103 -9999.0 0.0 -0.336 69.0 69.0 NCK1/GIT1 0.017 0.031 -9999.0 0.0 -0.5 1.0 1.0 mol:GDP -0.03 0.098 -9999.0 0.0 -0.357 68.0 68.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.005 0.104 -9999.0 0.0 -0.336 70.0 70.0 PIP5K1C 0.005 0.103 -9999.0 0.0 -0.336 68.0 68.0 LIMA1 0.007 0.067 -9999.0 0.0 -0.674 8.0 8.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.029 0.091 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.021 0.11 -9999.0 0.0 -0.588 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.099 0.17 -9999.0 0.0 -0.648 33.0 33.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.014 0.053 -9999.0 0.0 -0.463 10.0 10.0 MET -0.066 0.21 -9999.0 0.0 -0.605 108.0 108.0 PLEKHA7 0.004 0.107 -9999.0 0.0 -0.341 71.0 71.0 mol:GTP 0.025 0.051 -9999.0 0.0 -0.379 8.0 8.0 establishment of epithelial cell apical/basal polarity 0.027 0.1 -9999.0 0.0 -0.521 2.0 2.0 cortical actin cytoskeleton stabilization 0.001 0.091 -9999.0 0.0 -0.284 76.0 76.0 regulation of cell-cell adhesion 0.01 0.102 -9999.0 0.0 -0.49 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.001 0.091 -9999.0 0.0 -0.286 76.0 76.0