E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.14 -9999.0 0.0 -0.404 78.0 78.0 KLHL20 -0.002 0.083 0.181 8.0 -0.24 27.0 35.0 CYFIP2 0.007 0.101 -9999.0 0.0 -0.477 34.0 34.0 Rac1/GDP -0.009 0.103 0.257 11.0 -0.278 53.0 64.0 ENAH -0.031 0.133 -9999.0 0.0 -0.397 72.0 72.0 AP1M1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.019 -9999.0 0.0 -0.477 1.0 1.0 CDC42/GTP 0.003 0.065 -9999.0 0.0 -0.256 4.0 4.0 ABI1/Sra1/Nap1 -0.027 0.048 -9999.0 0.0 -0.163 35.0 35.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.031 0.1 -9999.0 0.0 -0.27 73.0 73.0 RAPGEF1 -0.033 0.132 0.236 7.0 -0.373 75.0 82.0 CTNND1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.154 -9999.0 0.0 -0.359 134.0 134.0 CRK -0.03 0.135 -9999.0 0.0 -0.403 73.0 73.0 E-cadherin/gamma catenin/alpha catenin 0.027 0.086 -9999.0 0.0 -0.3 47.0 47.0 alphaE/beta7 Integrin 0.027 0.067 -9999.0 0.0 -0.341 25.0 25.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.028 -9999.0 0.0 -0.267 3.0 3.0 DLG1 -0.04 0.147 -9999.0 0.0 -0.414 81.0 81.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.044 -9999.0 0.0 -0.19 4.0 4.0 MLLT4 0.025 0.032 -9999.0 0.0 -0.477 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.045 0.04 -9999.0 0.0 -0.263 10.0 10.0 PI3K -0.011 0.057 -9999.0 0.0 -0.244 4.0 4.0 ARF6 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.014 0.092 -9999.0 0.0 -0.351 47.0 47.0 TIAM1 0.022 0.058 -9999.0 0.0 -0.477 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.037 0.079 -9999.0 0.0 -0.252 49.0 49.0 AKT1 -0.011 0.041 0.149 1.0 -9999.0 0.0 1.0 PIK3R1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.004 0.118 -9999.0 0.0 -0.477 48.0 48.0 RhoA/GDP -0.007 0.103 0.257 11.0 -0.278 52.0 63.0 actin cytoskeleton organization 0.001 0.064 0.151 17.0 -0.174 27.0 44.0 CDC42/GDP -0.007 0.102 0.257 11.0 -0.277 53.0 64.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.0 0.065 -9999.0 0.0 -0.242 49.0 49.0 ITGB7 0.012 0.087 -9999.0 0.0 -0.477 25.0 25.0 RAC1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.041 0.085 -9999.0 0.0 -0.269 49.0 49.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.025 0.073 -9999.0 0.0 -0.25 49.0 49.0 mol:GDP -0.024 0.11 0.258 12.0 -0.313 58.0 70.0 CDC42/GTP/IQGAP1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.019 -9999.0 0.0 -0.477 1.0 1.0 p120 catenin/RhoA/GDP -0.001 0.107 0.266 9.0 -0.283 52.0 61.0 RAC1/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.005 0.063 0.153 7.0 -0.201 50.0 57.0 NME1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.415 81.0 81.0 regulation of cell-cell adhesion -0.003 0.055 -9999.0 0.0 -0.226 4.0 4.0 WASF2 -0.001 0.037 0.097 3.0 -0.118 6.0 9.0 Rap1/GTP 0.006 0.076 0.235 1.0 -0.289 4.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.1 -9999.0 0.0 -0.257 72.0 72.0 CCND1 -0.008 0.076 0.174 7.0 -0.25 50.0 57.0 VAV2 -0.034 0.175 -9999.0 0.0 -0.466 76.0 76.0 RAP1/GDP 0.003 0.087 0.259 4.0 -0.291 7.0 11.0 adherens junction assembly -0.037 0.142 -9999.0 0.0 -0.402 81.0 81.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.027 0.093 -9999.0 0.0 -0.252 71.0 71.0 E-cadherin/beta catenin -0.013 0.089 -9999.0 0.0 -0.311 65.0 65.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.041 0.147 -9999.0 0.0 -0.414 83.0 83.0 PIK3CA 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.039 0.114 -9999.0 0.0 -0.391 34.0 34.0 E-cadherin/beta catenin/alpha catenin 0.028 0.086 -9999.0 0.0 -0.294 49.0 49.0 ITGAE 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.036 0.157 -9999.0 0.0 -0.367 134.0 134.0