Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.07 -9999.0 0.0 -0.233 59.0 59.0 epithelial cell differentiation 0.033 0.077 -9999.0 0.0 -0.25 49.0 49.0 CYFIP2 0.007 0.101 -9999.0 0.0 -0.477 34.0 34.0 ENAH -0.008 0.065 0.265 9.0 -9999.0 0.0 9.0 EGFR -0.018 0.138 -9999.0 0.0 -0.477 67.0 67.0 EPHA2 0.024 0.04 -9999.0 0.0 -0.477 5.0 5.0 MYO6 -0.021 0.064 0.178 16.0 -0.243 50.0 66.0 CTNNB1 0.028 0.019 -9999.0 0.0 -0.477 1.0 1.0 ABI1/Sra1/Nap1 0.042 0.068 -9999.0 0.0 -0.295 30.0 30.0 AQP5 -0.095 0.194 -9999.0 0.0 -0.47 160.0 160.0 CTNND1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.062 0.176 16.0 -0.24 48.0 64.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.068 0.175 16.0 -0.243 59.0 75.0 EGF -0.056 0.181 -9999.0 0.0 -0.477 127.0 127.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.057 0.157 -9999.0 0.0 -0.452 96.0 96.0 cortical microtubule organization 0.033 0.077 -9999.0 0.0 -0.25 49.0 49.0 GO:0000145 -0.02 0.058 0.163 16.0 -0.229 48.0 64.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.037 0.079 -9999.0 0.0 -0.252 49.0 49.0 MLLT4 0.025 0.032 -9999.0 0.0 -0.477 3.0 3.0 ARF6/GDP -0.027 0.048 -9999.0 0.0 -0.225 42.0 42.0 ARF6 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.043 -9999.0 0.0 -0.267 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.007 0.061 -9999.0 0.0 -0.353 1.0 1.0 PVRL2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.021 0.062 0.178 14.0 -0.243 48.0 62.0 ARF6/GTP 0.058 0.046 -9999.0 0.0 -0.25 6.0 6.0 CDH1 -0.004 0.118 -9999.0 0.0 -0.477 48.0 48.0 EGFR/EGFR/EGF/EGF -0.039 0.136 -9999.0 0.0 -0.251 224.0 224.0 RhoA/GDP 0.034 0.075 -9999.0 0.0 -0.24 49.0 49.0 actin cytoskeleton organization -0.023 0.061 0.164 15.0 -0.24 50.0 65.0 IGF-1R heterotetramer -0.018 0.144 -9999.0 0.0 -0.477 74.0 74.0 GIT1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.018 0.144 -9999.0 0.0 -0.477 74.0 74.0 IGF1 -0.018 0.14 -9999.0 0.0 -0.477 69.0 69.0 DIAPH1 0.017 0.157 -9999.0 0.0 -0.59 27.0 27.0 Wnt receptor signaling pathway -0.033 0.077 0.25 49.0 -9999.0 0.0 49.0 RHOA 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.027 0.049 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.023 0.062 0.166 15.0 -0.245 50.0 65.0 EFNA1 0.024 0.021 -9999.0 0.0 -0.477 1.0 1.0 LPP -0.023 0.062 0.169 16.0 -0.235 52.0 68.0 Ephrin A1/EPHA2 0.022 0.069 -9999.0 0.0 -0.238 44.0 44.0 SEC6/SEC8 -0.03 0.053 -9999.0 0.0 -0.231 51.0 51.0 MGAT3 -0.025 0.069 0.178 15.0 -0.247 59.0 74.0 HGF/MET -0.009 0.123 -9999.0 0.0 -0.258 149.0 149.0 HGF -0.002 0.12 -9999.0 0.0 -0.477 49.0 49.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.07 -9999.0 0.0 -0.234 59.0 59.0 actin cable formation 0.033 0.097 0.27 41.0 -0.26 2.0 43.0 KIAA1543 -0.022 0.061 0.164 15.0 -0.237 50.0 65.0 KIFC3 -0.023 0.063 0.178 14.0 -0.244 51.0 65.0 NCK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.063 0.178 16.0 -0.243 48.0 64.0 NCK1/GIT1 0.039 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.033 0.077 -9999.0 0.0 -0.25 49.0 49.0 EXOC4 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.063 0.178 14.0 -0.244 50.0 64.0 PIP5K1C -0.021 0.063 0.178 16.0 -0.243 48.0 64.0 LIMA1 0.025 0.043 -9999.0 0.0 -0.477 6.0 6.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.01 0.093 0.296 20.0 -9999.0 0.0 20.0 adherens junction assembly -0.033 0.115 0.274 2.0 -0.598 17.0 19.0 IGF-1R heterotetramer/IGF1 -0.02 0.13 -9999.0 0.0 -0.262 171.0 171.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.027 -9999.0 0.0 -0.345 3.0 3.0 MET -0.018 0.142 -9999.0 0.0 -0.477 71.0 71.0 PLEKHA7 -0.022 0.065 0.178 15.0 -0.248 50.0 65.0 mol:GTP 0.051 0.042 -9999.0 0.0 -0.265 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.017 0.076 0.352 5.0 -0.272 1.0 6.0 cortical actin cytoskeleton stabilization 0.002 0.07 -9999.0 0.0 -0.233 59.0 59.0 regulation of cell-cell adhesion -0.023 0.061 0.164 15.0 -0.24 50.0 65.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.07 -9999.0 0.0 -0.234 59.0 59.0