Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.076 0.301 -9999.0 0.0 -1.08 15.0 15.0 IHH -0.008 0.074 -9999.0 0.0 -0.627 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.037 0.146 -9999.0 0.0 -0.532 11.0 11.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.145 0.527 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.045 0.186 -9999.0 0.0 -0.666 11.0 11.0 SMO -0.054 0.196 -9999.0 0.0 -0.708 11.0 11.0 AKT1 -0.004 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.008 0.12 -9999.0 0.0 -0.693 9.0 9.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.193 -9999.0 0.0 -0.693 11.0 11.0 STIL -0.044 0.173 -9999.0 0.0 -0.633 10.0 10.0 DHH N/PTCH2 -0.056 0.185 -9999.0 0.0 -0.501 43.0 43.0 DHH N/PTCH1 -0.057 0.197 -9999.0 0.0 -0.566 21.0 21.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.043 0.189 -9999.0 0.0 -0.684 24.0 24.0 PTHLH -0.138 0.435 -9999.0 0.0 -1.161 42.0 42.0 determination of left/right symmetry -0.052 0.193 -9999.0 0.0 -0.693 11.0 11.0 PIK3R1 0.008 0.054 -9999.0 0.0 -0.655 2.0 2.0 skeletal system development -0.135 0.426 -9999.0 0.0 -1.136 42.0 42.0 IHH N/Hhip -0.105 0.222 -9999.0 0.0 -0.518 66.0 66.0 DHH N/Hhip -0.126 0.243 -9999.0 0.0 -0.51 82.0 82.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.193 -9999.0 0.0 -0.693 11.0 11.0 pancreas development -0.126 0.266 -9999.0 0.0 -0.636 64.0 64.0 HHAT 0.008 0.054 -9999.0 0.0 -0.655 2.0 2.0 PI3K 0.016 0.041 -9999.0 0.0 -0.484 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.134 -9999.0 0.0 -0.699 11.0 11.0 somite specification -0.052 0.193 -9999.0 0.0 -0.693 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.053 0.179 -9999.0 0.0 -0.673 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.046 0.166 -9999.0 0.0 -0.57 18.0 18.0 SHH Np/Cholesterol/Megalin -0.047 0.155 -9999.0 0.0 -0.55 13.0 13.0 SHH -0.036 0.149 -9999.0 0.0 -0.437 36.0 36.0 catabolic process -0.033 0.177 -9999.0 0.0 -0.579 16.0 16.0 SMO/Vitamin D3 -0.06 0.189 -9999.0 0.0 -0.613 14.0 14.0 SHH Np/Cholesterol/Hhip -0.104 0.202 -9999.0 0.0 -0.434 67.0 67.0 LRP2 -0.029 0.156 -9999.0 0.0 -0.629 19.0 19.0 receptor-mediated endocytosis -0.094 0.171 -9999.0 0.0 -0.67 10.0 10.0 SHH Np/Cholesterol/BOC -0.034 0.136 -9999.0 0.0 -0.47 10.0 10.0 SHH Np/Cholesterol/CDO -0.036 0.136 -9999.0 0.0 -0.347 47.0 47.0 mesenchymal cell differentiation 0.104 0.2 0.406 86.0 -9999.0 0.0 86.0 mol:Vitamin D3 -0.051 0.18 -9999.0 0.0 -0.675 9.0 9.0 IHH N/PTCH2 -0.027 0.137 -9999.0 0.0 -0.501 22.0 22.0 CDON -0.013 0.126 -9999.0 0.0 -0.632 12.0 12.0 IHH N/PTCH1 -0.033 0.179 -9999.0 0.0 -0.583 16.0 16.0 Megalin/LRPAP1 -0.013 0.117 -9999.0 0.0 -0.461 19.0 19.0 PTCH2 -0.031 0.161 -9999.0 0.0 -0.618 21.0 21.0 SHH Np/Cholesterol -0.038 0.113 -9999.0 0.0 -0.341 36.0 36.0 PTCH1 -0.033 0.178 -9999.0 0.0 -0.581 16.0 16.0 HHIP -0.127 0.266 -9999.0 0.0 -0.637 64.0 64.0