Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	30.0	2793.0	91.0	-1.024	0.828	1000.0	-1000.0	-0.166	-1000.0
Ephrin A  reverse signaling	27.0	192.0	7.0	-0.212	-0.0	1000.0	-1000.0	-0.049	-1000.0
IL23-mediated signaling events	27.0	1646.0	60.0	-0.759	0.013	1000.0	-1000.0	-0.221	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	23.0	1589.0	68.0	-0.648	0.193	1000.0	-1000.0	-0.172	-1000.0
Glypican 2 network	20.0	83.0	4.0	-0.109	-0.062	1000.0	-1000.0	-0.058	-1000.0
IL12-mediated signaling events	15.0	1363.0	87.0	-0.377	0.126	1000.0	-1000.0	-0.17	-1000.0
Syndecan-1-mediated signaling events	15.0	542.0	34.0	-0.288	0.013	1000.0	-1000.0	-0.116	-1000.0
Signaling events mediated by the Hedgehog family	15.0	831.0	52.0	-0.292	0.266	1000.0	-1000.0	-0.127	-1000.0
Glucocorticoid receptor regulatory network	15.0	1714.0	114.0	-0.601	0.373	1000.0	-1000.0	-0.099	-1000.0
Calcium signaling in the CD4+ TCR pathway	14.0	453.0	31.0	-0.387	0.01	1000.0	-1000.0	-0.155	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	634.0	46.0	-0.453	0.044	1000.0	-1000.0	-0.124	-1000.0
a4b1 and a4b7 Integrin signaling	11.0	58.0	5.0	-0.1	-0.027	1000.0	-1000.0	-0.054	-1000.0
Glypican 1 network	11.0	550.0	48.0	-0.336	0.029	1000.0	-1000.0	-0.092	-1000.0
Wnt signaling	11.0	80.0	7.0	-0.13	-0.011	1000.0	-1000.0	-0.064	-1000.0
IL6-mediated signaling events	11.0	852.0	75.0	-0.334	0.063	1000.0	-1000.0	-0.144	-1000.0
FOXM1 transcription factor network	11.0	606.0	51.0	-0.204	0.036	1000.0	-1000.0	-0.221	-1000.0
amb2 Integrin signaling	10.0	898.0	82.0	-0.377	0.013	1000.0	-1000.0	-0.143	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	844.0	82.0	-0.276	0.013	1000.0	-1000.0	-0.134	-1000.0
Endothelins	10.0	1051.0	96.0	-0.26	0.034	1000.0	-1000.0	-0.135	-1000.0
Effects of Botulinum toxin	10.0	260.0	26.0	-0.22	0.013	1000.0	-1000.0	-0.101	-1000.0
p75(NTR)-mediated signaling	9.0	1212.0	125.0	-0.346	0.013	1000.0	-1000.0	-0.164	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	341.0	37.0	-0.245	0.013	1000.0	-1000.0	-0.13	-1000.0
Nongenotropic Androgen signaling	9.0	477.0	52.0	-0.163	0.068	1000.0	-1000.0	-0.096	-1000.0
Syndecan-4-mediated signaling events	9.0	610.0	67.0	-0.159	0.013	1000.0	-1000.0	-0.137	-1000.0
ErbB4 signaling events	8.0	602.0	69.0	-0.274	0.068	1000.0	-1000.0	-0.118	-1000.0
Visual signal transduction: Cones	8.0	331.0	38.0	-0.156	0.013	1000.0	-1000.0	-0.087	-1000.0
Noncanonical Wnt signaling pathway	8.0	209.0	26.0	-0.154	0.013	1000.0	-1000.0	-0.148	-1000.0
Thromboxane A2 receptor signaling	8.0	895.0	105.0	-0.172	0.07	1000.0	-1000.0	-0.124	-1000.0
HIF-1-alpha transcription factor network	8.0	647.0	76.0	-0.421	0.026	1000.0	-1000.0	-0.226	-1000.0
EPO signaling pathway	8.0	453.0	55.0	-0.307	0.015	1000.0	-1000.0	-0.145	-1000.0
Reelin signaling pathway	8.0	490.0	56.0	-0.279	0.013	1000.0	-1000.0	-0.133	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	358.0	44.0	-0.255	0.013	1000.0	-1000.0	-0.076	-1000.0
TCGA08_retinoblastoma	8.0	70.0	8.0	-0.029	0.018	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	8.0	416.0	52.0	-0.272	0.013	1000.0	-1000.0	-0.124	-1000.0
Signaling events mediated by PTP1B	7.0	585.0	76.0	-0.281	0.033	1000.0	-1000.0	-0.106	-1000.0
Integrins in angiogenesis	7.0	665.0	84.0	-0.229	0.02	1000.0	-1000.0	-0.15	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	725.0	93.0	-0.159	0.021	1000.0	-1000.0	-0.127	-1000.0
IL27-mediated signaling events	7.0	382.0	51.0	-0.334	0.025	1000.0	-1000.0	-0.127	-1000.0
Aurora B signaling	7.0	469.0	67.0	-0.127	0.013	1000.0	-1000.0	-0.118	-1000.0
Syndecan-2-mediated signaling events	6.0	478.0	69.0	-0.193	0.023	1000.0	-1000.0	-0.106	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	376.0	61.0	-0.273	0.026	1000.0	-1000.0	-0.125	-1000.0
BMP receptor signaling	6.0	562.0	81.0	-0.206	0.049	1000.0	-1000.0	-0.148	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	316.0	52.0	-0.177	0.035	1000.0	-1000.0	-0.105	-1000.0
S1P1 pathway	6.0	245.0	36.0	-0.159	0.013	1000.0	-1000.0	-0.088	-1000.0
BCR signaling pathway	6.0	628.0	99.0	-0.231	0.029	1000.0	-1000.0	-0.151	-1000.0
EGFR-dependent Endothelin signaling events	6.0	137.0	21.0	-0.136	0.013	1000.0	-1000.0	-0.119	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	788.0	120.0	-0.224	0.125	1000.0	-1000.0	-0.134	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	102.0	17.0	-0.084	0.012	1000.0	-1000.0	-0.076	-1000.0
Caspase cascade in apoptosis	5.0	429.0	74.0	-0.13	0.036	1000.0	-1000.0	-0.081	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	188.0	34.0	-0.056	0.013	1000.0	-1000.0	-0.088	-1000.0
Osteopontin-mediated events	5.0	201.0	38.0	-0.224	0.013	1000.0	-1000.0	-0.169	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	88.0	17.0	-0.079	0.013	1000.0	-1000.0	-0.106	-1000.0
Arf6 signaling events	5.0	325.0	62.0	-0.214	0.013	1000.0	-1000.0	-0.092	-1000.0
PDGFR-alpha signaling pathway	5.0	251.0	44.0	-0.297	0.03	1000.0	-1000.0	-0.098	-1000.0
S1P5 pathway	5.0	91.0	17.0	-0.103	0.06	1000.0	-1000.0	-0.071	-1000.0
Ephrin B reverse signaling	5.0	266.0	48.0	-0.114	0.084	1000.0	-1000.0	-0.109	-1000.0
Syndecan-3-mediated signaling events	5.0	176.0	35.0	-0.193	0.013	1000.0	-1000.0	-0.116	-1000.0
Canonical Wnt signaling pathway	5.0	267.0	51.0	-0.273	0.084	1000.0	-1000.0	-0.09	-1000.0
EPHB forward signaling	5.0	470.0	85.0	-0.182	0.117	1000.0	-1000.0	-0.143	-1000.0
LPA receptor mediated events	5.0	560.0	102.0	-0.225	0.036	1000.0	-1000.0	-0.147	-1000.0
Regulation of Telomerase	5.0	536.0	102.0	-0.266	0.046	1000.0	-1000.0	-0.14	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	498.0	88.0	-0.213	0.015	1000.0	-1000.0	-0.171	-1000.0
Signaling events mediated by PRL	5.0	189.0	34.0	-0.22	0.013	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	453.0	78.0	-0.239	0.098	1000.0	-1000.0	-0.114	-1000.0
LPA4-mediated signaling events	4.0	54.0	12.0	-0.045	0.022	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	627.0	136.0	-0.23	0.21	1000.0	-1000.0	-0.113	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	258.0	54.0	-0.234	0.025	1000.0	-1000.0	-0.152	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	346.0	85.0	-0.225	0.034	1000.0	-1000.0	-0.116	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	409.0	97.0	-0.225	0.028	1000.0	-1000.0	-0.139	-1000.0
PLK1 signaling events	4.0	385.0	85.0	-0.088	0.022	1000.0	-1000.0	-0.088	-1000.0
Nectin adhesion pathway	4.0	262.0	63.0	-0.103	0.027	1000.0	-1000.0	-0.118	-1000.0
IL1-mediated signaling events	4.0	250.0	62.0	-0.182	0.066	1000.0	-1000.0	-0.162	-1000.0
TCGA08_p53	4.0	28.0	7.0	-0.024	0.017	1000.0	-1000.0	-0.025	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	166.0	36.0	-0.1	0.053	1000.0	-1000.0	-0.109	-1000.0
IGF1 pathway	4.0	280.0	57.0	-0.112	0.013	1000.0	-1000.0	-0.158	-1000.0
Plasma membrane estrogen receptor signaling	4.0	386.0	86.0	-0.11	0.027	1000.0	-1000.0	-0.131	-1000.0
VEGFR1 specific signals	4.0	245.0	56.0	-0.134	0.033	1000.0	-1000.0	-0.114	-1000.0
ErbB2/ErbB3 signaling events	3.0	251.0	65.0	-0.135	0.027	1000.0	-1000.0	-0.112	-1000.0
Coregulation of Androgen receptor activity	3.0	263.0	76.0	-0.081	0.026	1000.0	-1000.0	-0.076	-1000.0
Cellular roles of Anthrax toxin	3.0	131.0	39.0	-0.13	0.021	1000.0	-1000.0	-0.043	-1000.0
TRAIL signaling pathway	3.0	174.0	48.0	-0.096	0.038	1000.0	-1000.0	-0.113	-1000.0
HIF-2-alpha transcription factor network	3.0	135.0	43.0	-0.208	0.075	1000.0	-1000.0	-0.133	-1000.0
FAS signaling pathway (CD95)	3.0	163.0	47.0	-0.408	0.016	1000.0	-1000.0	-0.081	-1000.0
IL2 signaling events mediated by PI3K	3.0	210.0	58.0	-0.156	0.039	1000.0	-1000.0	-0.126	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	471.0	125.0	-0.131	0.018	1000.0	-1000.0	-0.156	-1000.0
IL2 signaling events mediated by STAT5	3.0	84.0	22.0	-0.082	0.032	1000.0	-1000.0	-0.071	-1000.0
S1P3 pathway	3.0	136.0	42.0	-0.131	0.018	1000.0	-1000.0	-0.088	-1000.0
S1P4 pathway	3.0	91.0	25.0	-0.103	0.016	1000.0	-1000.0	-0.086	-1000.0
Canonical NF-kappaB pathway	2.0	79.0	39.0	-0.13	0.077	1000.0	-1000.0	-0.136	-1000.0
BARD1 signaling events	2.0	155.0	57.0	-0.05	0.046	1000.0	-1000.0	-0.109	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	78.0	28.0	-0.103	0.025	1000.0	-1000.0	-0.092	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	0.002	0.009	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	2.0	47.0	22.0	-0.032	0.026	1000.0	-1000.0	-0.106	-1000.0
Aurora A signaling	2.0	158.0	60.0	-0.098	0.031	1000.0	-1000.0	-0.097	-1000.0
Aurora C signaling	2.0	20.0	7.0	-0.046	0.0	1000.0	-1000.0	-0.065	-1000.0
Ceramide signaling pathway	2.0	184.0	76.0	-0.13	0.025	1000.0	-1000.0	-0.109	-1000.0
Signaling events mediated by HDAC Class III	2.0	102.0	40.0	-0.103	0.026	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	41.0	15.0	-0.0	0.017	1000.0	-1000.0	-0.063	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	94.0	45.0	-0.13	0.055	1000.0	-1000.0	-0.148	-1000.0
Regulation of p38-alpha and p38-beta	2.0	152.0	54.0	-0.199	0.013	1000.0	-1000.0	-0.107	-1000.0
TCGA08_rtk_signaling	2.0	56.0	26.0	-0.072	0.053	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	184.0	74.0	-0.121	0.068	1000.0	-1000.0	-0.143	-1000.0
Class I PI3K signaling events	2.0	196.0	73.0	-0.199	0.034	1000.0	-1000.0	-0.122	-1000.0
Insulin Pathway	2.0	155.0	74.0	-0.193	0.04	1000.0	-1000.0	-0.141	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	85.0	33.0	-0.134	0.034	1000.0	-1000.0	-0.103	-1000.0
p38 MAPK signaling pathway	2.0	103.0	44.0	-0.087	0.02	1000.0	-1000.0	-0.102	-1000.0
Regulation of Androgen receptor activity	2.0	180.0	70.0	-0.24	0.084	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by HDAC Class II	1.0	122.0	75.0	-0.156	0.023	1000.0	-1000.0	-0.116	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	78.0	65.0	-0.204	0.075	1000.0	-1000.0	-0.093	-1000.0
Arf6 downstream pathway	1.0	65.0	43.0	-0.021	0.022	1000.0	-1000.0	-0.069	-1000.0
Insulin-mediated glucose transport	1.0	35.0	32.0	-0.083	0.035	1000.0	-1000.0	-0.106	-1000.0
IFN-gamma pathway	1.0	119.0	68.0	-0.1	0.044	1000.0	-1000.0	-0.137	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	93.0	68.0	-0.083	0.039	1000.0	-1000.0	-0.106	-1000.0
ceramide signaling pathway	1.0	67.0	49.0	-0.13	0.028	1000.0	-1000.0	-0.088	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	159.0	83.0	-0.083	0.056	1000.0	-1000.0	-0.117	-1000.0
FoxO family signaling	1.0	72.0	64.0	-0.131	0.106	1000.0	-1000.0	-0.12	-1000.0
Retinoic acid receptors-mediated signaling	1.0	114.0	58.0	-0.098	0.039	1000.0	-1000.0	-0.113	-1000.0
Atypical NF-kappaB pathway	1.0	40.0	31.0	-0.044	0.04	1000.0	-1000.0	-0.118	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	105.0	76.0	-0.035	0.058	1000.0	-1000.0	-0.127	-1000.0
Arf6 trafficking events	1.0	77.0	71.0	-0.105	0.047	1000.0	-1000.0	-0.12	-1000.0
Rapid glucocorticoid signaling	1.0	29.0	20.0	-0.025	0.013	1000.0	-1000.0	-0.069	-1000.0
PDGFR-beta signaling pathway	1.0	97.0	97.0	-0.109	0.051	1000.0	-1000.0	-0.145	-1000.0
E-cadherin signaling in keratinocytes	1.0	82.0	43.0	-0.056	0.046	1000.0	-1000.0	-0.124	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	-0.015	0.013	1000.0	-1000.0	-0.071	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	-0.02	0.048	1000.0	-1000.0	-0.117	-1000.0
mTOR signaling pathway	0.0	47.0	53.0	-0.026	0.037	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	0.0	97.0	104.0	-0.13	0.053	1000.0	-1000.0	-0.116	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.003	0.031	1000.0	-1000.0	-0.096	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.006	0.035	1000.0	-1000.0	-0.08	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.013	1000.0	-1000.0	-0.106	-1000.0
Total	735	45004	7203	-23.6688662237	6.01211331151	131000	-131000	-14.6988498295	-131000