Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.183 0.294 -9999.0 0.0 -0.777 38.0 38.0 IHH -0.278 0.301 -9999.0 0.0 -0.566 133.0 133.0 SHH Np/Cholesterol/GAS1 -0.125 0.198 -9999.0 0.0 -0.41 70.0 70.0 LRPAP1 0.006 0.064 -9999.0 0.0 -0.596 3.0 3.0 dorsoventral neural tube patterning 0.125 0.196 0.407 70.0 -9999.0 0.0 70.0 SMO/beta Arrestin2 -0.18 0.264 -9999.0 0.0 -0.572 56.0 56.0 SMO -0.196 0.279 -9999.0 0.0 -0.511 93.0 93.0 AKT1 -0.092 0.18 -9999.0 0.0 -0.602 17.0 17.0 ARRB2 0.012 0.027 -9999.0 0.0 -0.433 1.0 1.0 BOC -0.024 0.13 -9999.0 0.0 -0.464 21.0 21.0 ADRBK1 0.012 0.027 -9999.0 0.0 -0.433 1.0 1.0 heart looping -0.192 0.272 -9999.0 0.0 -0.501 93.0 93.0 STIL -0.187 0.246 -9999.0 0.0 -0.571 57.0 57.0 DHH N/PTCH2 -0.032 0.149 -9999.0 0.0 -0.429 30.0 30.0 DHH N/PTCH1 -0.166 0.243 -9999.0 0.0 -0.583 41.0 41.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.433 2.0 2.0 DHH -0.027 0.147 -9999.0 0.0 -0.569 18.0 18.0 PTHLH -0.216 0.353 -9999.0 0.0 -0.947 35.0 35.0 determination of left/right symmetry -0.192 0.272 -9999.0 0.0 -0.501 93.0 93.0 PIK3R1 -0.024 0.139 -9999.0 0.0 -0.533 18.0 18.0 skeletal system development -0.213 0.346 -9999.0 0.0 -0.93 35.0 35.0 IHH N/Hhip -0.253 0.272 -9999.0 0.0 -0.509 121.0 121.0 DHH N/Hhip -0.107 0.206 -9999.0 0.0 -0.421 76.0 76.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.192 0.272 -9999.0 0.0 -0.501 93.0 93.0 pancreas development -0.12 0.243 -9999.0 0.0 -0.556 62.0 62.0 HHAT -0.017 0.131 -9999.0 0.0 -0.596 13.0 13.0 PI3K -0.01 0.105 -9999.0 0.0 -0.372 20.0 20.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.092 0.209 -9999.0 0.0 -0.495 55.0 55.0 somite specification -0.192 0.272 -9999.0 0.0 -0.501 93.0 93.0 SHH Np/Cholesterol/PTCH1 -0.202 0.261 -9999.0 0.0 -0.599 59.0 59.0 SHH Np/Cholesterol/PTCH2 -0.085 0.171 -9999.0 0.0 -0.368 59.0 59.0 SHH Np/Cholesterol/Megalin -0.173 0.199 -9999.0 0.0 -0.406 86.0 86.0 SHH -0.097 0.197 -9999.0 0.0 -0.403 74.0 74.0 catabolic process -0.169 0.239 -9999.0 0.0 -0.421 102.0 102.0 SMO/Vitamin D3 -0.213 0.282 -9999.0 0.0 -0.638 59.0 59.0 SHH Np/Cholesterol/Hhip -0.143 0.211 -9999.0 0.0 -0.417 80.0 80.0 LRP2 -0.178 0.248 -9999.0 0.0 -0.489 101.0 101.0 receptor-mediated endocytosis -0.264 0.285 -9999.0 0.0 -0.607 81.0 81.0 SHH Np/Cholesterol/BOC -0.088 0.18 -9999.0 0.0 -0.398 53.0 53.0 SHH Np/Cholesterol/CDO -0.077 0.171 -9999.0 0.0 -0.38 51.0 51.0 mesenchymal cell differentiation 0.142 0.209 0.414 80.0 -9999.0 0.0 80.0 mol:Vitamin D3 -0.202 0.263 -9999.0 0.0 -0.602 59.0 59.0 IHH N/PTCH2 -0.181 0.21 -9999.0 0.0 -0.417 102.0 102.0 CDON -0.003 0.088 -9999.0 0.0 -0.469 9.0 9.0 IHH N/PTCH1 -0.17 0.243 -9999.0 0.0 -0.426 102.0 102.0 Megalin/LRPAP1 -0.124 0.186 -9999.0 0.0 -0.35 103.0 103.0 PTCH2 -0.017 0.127 -9999.0 0.0 -0.531 15.0 15.0 SHH Np/Cholesterol -0.076 0.153 -9999.0 0.0 -0.355 50.0 50.0 PTCH1 -0.169 0.241 -9999.0 0.0 -0.422 102.0 102.0 HHIP -0.12 0.243 -9999.0 0.0 -0.556 62.0 62.0