Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	56.0	2947.0	52.0	-0.278	0.142	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	38.0	1759.0	46.0	-0.47	0.013	1000.0	-1000.0	-0.107	-1000.0
IL23-mediated signaling events	38.0	2311.0	60.0	-0.518	0.013	1000.0	-1000.0	-0.166	-1000.0
Syndecan-1-mediated signaling events	37.0	1280.0	34.0	-0.208	0.013	1000.0	-1000.0	-0.048	-1000.0
Ephrin A  reverse signaling	35.0	248.0	7.0	-0.083	0.0	1000.0	-1000.0	-0.019	-1000.0
TCGA08_retinoblastoma	35.0	281.0	8.0	-0.101	0.052	1000.0	-1000.0	-0.018	-1000.0
IL4-mediated signaling events	34.0	3156.0	91.0	-0.695	0.541	1000.0	-1000.0	-0.168	-1000.0
Wnt signaling	34.0	243.0	7.0	-0.147	0.009	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	32.0	2466.0	76.0	-0.367	0.022	1000.0	-1000.0	-0.148	-1000.0
Signaling mediated by p38-alpha and p38-beta	28.0	1255.0	44.0	-0.191	0.013	1000.0	-1000.0	-0.037	-1000.0
TCR signaling in naïve CD8+ T cells	27.0	2548.0	93.0	-0.139	0.072	1000.0	-1000.0	-0.075	-1000.0
Noncanonical Wnt signaling pathway	26.0	686.0	26.0	-0.147	0.013	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	25.0	3247.0	125.0	-0.311	0.034	1000.0	-1000.0	-0.092	-1000.0
Glypican 1 network	24.0	1155.0	48.0	-0.128	0.018	1000.0	-1000.0	-0.041	-1000.0
Signaling events regulated by Ret tyrosine kinase	24.0	2030.0	82.0	-0.173	0.013	1000.0	-1000.0	-0.084	-1000.0
Ephrin B reverse signaling	24.0	1160.0	48.0	-0.118	0.078	1000.0	-1000.0	-0.065	-1000.0
BMP receptor signaling	23.0	1918.0	81.0	-0.207	0.043	1000.0	-1000.0	-0.087	-1000.0
EPHB forward signaling	23.0	2033.0	85.0	-0.16	0.127	1000.0	-1000.0	-0.086	-1000.0
IL12-mediated signaling events	22.0	1934.0	87.0	-0.251	0.031	1000.0	-1000.0	-0.138	-1000.0
Glucocorticoid receptor regulatory network	22.0	2619.0	114.0	-0.541	0.271	1000.0	-1000.0	-0.065	-1000.0
Syndecan-4-mediated signaling events	22.0	1477.0	67.0	-0.154	0.021	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	21.0	1710.0	78.0	-0.15	0.07	1000.0	-1000.0	-0.064	-1000.0
amb2 Integrin signaling	20.0	1680.0	82.0	-0.281	0.018	1000.0	-1000.0	-0.071	-1000.0
Nectin adhesion pathway	20.0	1271.0	63.0	-0.094	0.026	1000.0	-1000.0	-0.072	-1000.0
Endothelins	20.0	1964.0	96.0	-0.248	0.017	1000.0	-1000.0	-0.087	-1000.0
Osteopontin-mediated events	19.0	740.0	38.0	-0.069	0.013	1000.0	-1000.0	-0.089	-1000.0
Glypican 2 network	19.0	78.0	4.0	-0.018	-1000.0	1000.0	-1000.0	-0.014	-1000.0
LPA receptor mediated events	19.0	1946.0	102.0	-0.151	0.016	1000.0	-1000.0	-0.08	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1340.0	68.0	-0.291	0.099	1000.0	-1000.0	-0.136	-1000.0
Caspase cascade in apoptosis	18.0	1395.0	74.0	-0.11	0.039	1000.0	-1000.0	-0.045	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	18.0	636.0	34.0	-0.058	0.013	1000.0	-1000.0	-0.036	-1000.0
Syndecan-2-mediated signaling events	18.0	1290.0	69.0	-0.08	0.02	1000.0	-1000.0	-0.028	-1000.0
BCR signaling pathway	18.0	1825.0	99.0	-0.171	0.017	1000.0	-1000.0	-0.083	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1575.0	86.0	-0.098	0.088	1000.0	-1000.0	-0.082	-1000.0
FOXM1 transcription factor network	18.0	934.0	51.0	-0.208	0.028	1000.0	-1000.0	-0.164	-1000.0
Thromboxane A2 receptor signaling	16.0	1706.0	105.0	-0.104	0.022	1000.0	-1000.0	-0.064	-1000.0
Reelin signaling pathway	16.0	947.0	56.0	-0.156	0.023	1000.0	-1000.0	-0.075	-1000.0
Canonical Wnt signaling pathway	16.0	863.0	51.0	-0.275	0.11	1000.0	-1000.0	-0.059	-1000.0
Effects of Botulinum toxin	16.0	431.0	26.0	-0.118	0.014	1000.0	-1000.0	-0.059	-1000.0
IGF1 pathway	16.0	948.0	57.0	-0.067	0.027	1000.0	-1000.0	-0.084	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	16.0	1944.0	120.0	-0.16	0.131	1000.0	-1000.0	-0.077	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	929.0	61.0	-0.275	0.043	1000.0	-1000.0	-0.068	-1000.0
TCGA08_p53	15.0	105.0	7.0	-0.073	0.043	1000.0	-1000.0	-0.01	-1000.0
Integrins in angiogenesis	15.0	1282.0	84.0	-0.126	0.02	1000.0	-1000.0	-0.089	-1000.0
LPA4-mediated signaling events	14.0	174.0	12.0	-0.047	0.016	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PTP1B	14.0	1115.0	76.0	-0.159	0.017	1000.0	-1000.0	-0.068	-1000.0
IL6-mediated signaling events	14.0	1117.0	75.0	-0.211	0.037	1000.0	-1000.0	-0.075	-1000.0
PDGFR-alpha signaling pathway	13.0	603.0	44.0	-0.068	0.021	1000.0	-1000.0	-0.069	-1000.0
Nongenotropic Androgen signaling	13.0	717.0	52.0	-0.085	0.013	1000.0	-1000.0	-0.056	-1000.0
Coregulation of Androgen receptor activity	12.0	934.0	76.0	-0.102	0.024	1000.0	-1000.0	-0.031	-1000.0
PLK2 and PLK4 events	12.0	36.0	3.0	-0.007	-0.006	1000.0	-1000.0	-0.012	-1000.0
JNK signaling in the CD4+ TCR pathway	12.0	205.0	17.0	-0.048	0.013	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	12.0	489.0	39.0	-0.093	0.013	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	12.0	786.0	62.0	-0.085	0.019	1000.0	-1000.0	-0.045	-1000.0
IL1-mediated signaling events	12.0	780.0	62.0	-0.101	0.061	1000.0	-1000.0	-0.088	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	12.0	627.0	52.0	-0.116	0.021	1000.0	-1000.0	-0.047	-1000.0
Calcium signaling in the CD4+ TCR pathway	12.0	391.0	31.0	-0.189	0.013	1000.0	-1000.0	-0.064	-1000.0
FAS signaling pathway (CD95)	11.0	523.0	47.0	-0.073	0.025	1000.0	-1000.0	-0.047	-1000.0
a4b1 and a4b7 Integrin signaling	10.0	53.0	5.0	-0.012	-0.0	1000.0	-1000.0	-0.017	-1000.0
S1P1 pathway	10.0	382.0	36.0	-0.164	0.013	1000.0	-1000.0	-0.057	-1000.0
IL27-mediated signaling events	10.0	527.0	51.0	-0.108	0.039	1000.0	-1000.0	-0.095	-1000.0
IL2 signaling events mediated by STAT5	10.0	228.0	22.0	-0.037	0.014	1000.0	-1000.0	-0.057	-1000.0
EGFR-dependent Endothelin signaling events	10.0	229.0	21.0	-0.083	0.02	1000.0	-1000.0	-0.069	-1000.0
Visual signal transduction: Rods	10.0	552.0	52.0	-0.11	0.013	1000.0	-1000.0	-0.072	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1298.0	136.0	-0.262	0.06	1000.0	-1000.0	-0.059	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	9.0	797.0	85.0	-0.039	0.013	1000.0	-1000.0	-0.066	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	945.0	97.0	-0.07	0.027	1000.0	-1000.0	-0.076	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	348.0	37.0	-0.059	0.019	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class III	9.0	380.0	40.0	-0.126	0.023	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	9.0	540.0	58.0	-0.11	0.025	1000.0	-1000.0	-0.076	-1000.0
Syndecan-3-mediated signaling events	9.0	320.0	35.0	-0.092	0.034	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	9.0	562.0	58.0	-0.088	0.021	1000.0	-1000.0	-0.084	-1000.0
Regulation of Telomerase	9.0	947.0	102.0	-0.187	0.036	1000.0	-1000.0	-0.112	-1000.0
Angiopoietin receptor Tie2-mediated signaling	9.0	846.0	88.0	-0.118	0.018	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by PRL	9.0	326.0	34.0	-0.121	0.02	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	9.0	680.0	70.0	-0.147	0.025	1000.0	-1000.0	-0.068	-1000.0
ErbB4 signaling events	8.0	616.0	69.0	-0.073	0.026	1000.0	-1000.0	-0.084	-1000.0
BARD1 signaling events	8.0	496.0	57.0	-0.03	0.032	1000.0	-1000.0	-0.06	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	461.0	54.0	-0.156	0.026	1000.0	-1000.0	-0.09	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	563.0	65.0	-0.253	0.041	1000.0	-1000.0	-0.061	-1000.0
TRAIL signaling pathway	8.0	430.0	48.0	-0.04	0.026	1000.0	-1000.0	-0.072	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	274.0	33.0	-0.111	0.036	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	150.0	17.0	-0.03	0.02	1000.0	-1000.0	-0.036	-1000.0
Ceramide signaling pathway	7.0	586.0	76.0	-0.083	0.038	1000.0	-1000.0	-0.051	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	347.0	45.0	-0.079	0.032	1000.0	-1000.0	-0.086	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	172.0	28.0	-0.033	0.03	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Cones	6.0	255.0	38.0	-0.04	0.009	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	6.0	360.0	55.0	-0.043	0.029	1000.0	-1000.0	-0.084	-1000.0
IFN-gamma pathway	6.0	434.0	68.0	-0.117	0.036	1000.0	-1000.0	-0.09	-1000.0
S1P5 pathway	6.0	114.0	17.0	-0.033	0.013	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	99.0	15.0	-0.013	0.018	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	6.0	172.0	26.0	-0.046	0.034	1000.0	-1000.0	-0.018	-1000.0
Insulin Pathway	6.0	483.0	74.0	-0.118	0.034	1000.0	-1000.0	-0.073	-1000.0
Aurora B signaling	6.0	443.0	67.0	-0.167	0.017	1000.0	-1000.0	-0.066	-1000.0
ErbB2/ErbB3 signaling events	5.0	372.0	65.0	-0.053	0.03	1000.0	-1000.0	-0.066	-1000.0
ceramide signaling pathway	5.0	261.0	49.0	-0.065	0.02	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	5.0	257.0	43.0	-0.049	0.05	1000.0	-1000.0	-0.075	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	205.0	36.0	-0.059	0.026	1000.0	-1000.0	-0.071	-1000.0
S1P4 pathway	5.0	135.0	25.0	-0.033	0.018	1000.0	-1000.0	-0.039	-1000.0
p38 MAPK signaling pathway	5.0	253.0	44.0	-0.117	0.026	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class II	4.0	331.0	75.0	-0.071	0.033	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	4.0	242.0	53.0	-0.028	0.017	1000.0	-1000.0	-0.056	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	412.0	83.0	-0.1	0.053	1000.0	-1000.0	-0.077	-1000.0
Regulation of p38-alpha and p38-beta	4.0	259.0	54.0	-0.092	0.033	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	616.0	125.0	-0.065	0.047	1000.0	-1000.0	-0.093	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	315.0	74.0	-0.083	0.056	1000.0	-1000.0	-0.086	-1000.0
Class I PI3K signaling events	4.0	346.0	73.0	-0.092	0.026	1000.0	-1000.0	-0.064	-1000.0
VEGFR1 specific signals	4.0	226.0	56.0	-0.024	0.038	1000.0	-1000.0	-0.061	-1000.0
PDGFR-beta signaling pathway	4.0	438.0	97.0	-0.076	0.036	1000.0	-1000.0	-0.081	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.006	0.006	1000.0	-1000.0	-0.018	-1000.0
Canonical NF-kappaB pathway	3.0	141.0	39.0	-0.066	0.064	1000.0	-1000.0	-0.088	-1000.0
Arf6 downstream pathway	3.0	143.0	43.0	-0.019	0.02	1000.0	-1000.0	-0.04	-1000.0
Aurora C signaling	3.0	24.0	7.0	-0.005	0.009	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	3.0	265.0	85.0	-0.029	0.031	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	224.0	68.0	-0.054	0.037	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	3.0	390.0	104.0	-0.066	0.049	1000.0	-1000.0	-0.062	-1000.0
FoxO family signaling	3.0	220.0	64.0	-0.111	0.098	1000.0	-1000.0	-0.074	-1000.0
Atypical NF-kappaB pathway	3.0	97.0	31.0	-0.024	0.032	1000.0	-1000.0	-0.045	-1000.0
S1P3 pathway	3.0	156.0	42.0	-0.018	0.022	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling events	3.0	16.0	5.0	0.009	0.018	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	2.0	174.0	60.0	-0.059	0.034	1000.0	-1000.0	-0.036	-1000.0
Insulin-mediated glucose transport	2.0	71.0	32.0	-0.054	0.028	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	193.0	76.0	-0.025	0.049	1000.0	-1000.0	-0.081	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	60.0	27.0	-0.009	0.029	1000.0	-1000.0	-0.049	-1000.0
Arf6 trafficking events	2.0	149.0	71.0	-0.019	0.033	1000.0	-1000.0	-0.077	-1000.0
Rapid glucocorticoid signaling	2.0	47.0	20.0	-0.007	0.013	1000.0	-1000.0	-0.018	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	35.0	23.0	-0.014	0.039	1000.0	-1000.0	-0.043	-1000.0
Circadian rhythm pathway	1.0	26.0	22.0	-0.013	0.044	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	1.0	66.0	43.0	-0.023	0.027	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	26.0	54.0	-0.002	0.028	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.039	1000.0	-1000.0	-0.028	-1000.0
Total	1617	96411	7203	-15.1742007498	-995.097662757	131000	-131000	-8.22049520711	-131000