rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(25), FADD(1), FAS(1), FASLG(2), GZMB(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(3), MCL1(1), MDM2(2), MYC(4), NFKB1(2), PARP1(3), PRF1(3), RELA(1), RIPK1(2), TP53(238), TRAF2(1)	17088240	317	233	222	21	53	41	56	56	104	7	<1.00e-15	<1.00e-15	<6.16e-14
2	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(9), ATR(19), CCNA1(4), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(61), DHFR(3), GSK3B(1), RB1(9), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(2), TP53(238)	13736583	364	226	238	19	48	43	56	61	148	8	<1.00e-15	<1.00e-15	<6.16e-14
3	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(14), IGF1R(7), MYC(4), POLR2A(9), PRKCA(2), RB1(9), TEP1(8), TERF1(3), TERT(1), TNKS(4), TP53(238), XRCC5(2)	12869416	304	223	212	29	49	41	60	52	95	7	7.27e-14	<1.00e-15	<6.16e-14
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(2), CDK4(4), CDKN1B(2), CDKN2A(61), CFL1(2), E2F2(3), MDM2(2), PRB1(8), TP53(238)	3842593	322	217	195	12	44	34	49	50	137	8	<1.00e-15	<1.00e-15	<6.16e-14
5	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(9), ATR(19), CHEK1(1), CHEK2(4), TP53(238), YWHAH(1)	7290074	272	213	180	10	43	35	47	52	88	7	1.48e-14	<1.00e-15	<6.16e-14
6	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(1), MYC(4), SP1(1), SP3(1), TP53(238)	3219260	245	207	153	7	41	28	42	42	85	7	<1.00e-15	<1.00e-15	<6.16e-14
7	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IGF1R(7), IRS1(1), MAP2K1(4), MAPK8(4), PIK3CA(64), PIK3R1(6), PTPN11(1), RAF1(2), RASA1(14), SHC1(1), SOS1(8)	11293994	131	109	83	5	11	47	32	24	17	0	2.07e-12	<1.00e-15	<6.16e-14
8	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), MAP2K1(4), MAPK8(4), NGFR(1), PIK3CA(64), PIK3R1(6), PLCG1(5), RAF1(2), SHC1(1), SOS1(8)	8695189	114	93	68	3	9	46	29	21	9	0	1.09e-12	<1.00e-15	<6.16e-14
9	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), HRAS(11), NTRK1(3), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), SHC1(1), SOS1(8)	7103380	102	87	56	5	6	49	21	23	3	0	4.12e-10	<1.00e-15	<6.16e-14
10	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CHUK(3), GH1(1), GHR(4), NFKB1(2), PDPK1(2), PIK3CA(64), PIK3R1(6), RELA(1), YWHAH(1)	6437782	87	81	46	4	3	49	8	23	4	0	2.86e-09	<1.00e-15	<6.16e-14
11	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), BCL2L1(2), CDC42(1), CHUK(3), ELK1(1), HRAS(11), MAP2K1(4), NFKB1(2), PIK3CA(64), PIK3R1(6), RAC1(10), RAF1(2), RALBP1(2), RALGDS(6), RELA(1), RHOA(4)	8688239	122	96	71	7	12	54	26	24	6	0	4.14e-11	1.33e-15	7.41e-14
12	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(25), CHUK(3), FADD(1), FAS(1), FASLG(2), GZMB(1), HELLS(4), IKBKB(5), IRF1(5), IRF2(3), IRF3(1), IRF4(2), IRF5(1), IRF6(4), IRF7(2), LTA(1), MAP2K4(1), MAP3K1(3), MAPK10(3), MDM2(2), MYC(4), NFKB1(2), NFKBIB(1), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(2), TNFRSF10B(1), TNFRSF21(2), TNFRSF25(2), TP53(238), TRAF2(1), TRAF3(3)	26196004	362	240	267	32	61	55	65	61	113	7	<1.00e-15	1.44e-15	7.41e-14
13	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(61), MDM2(2), MYC(4), PIK3CA(64), PIK3R1(6), POLR1A(5), POLR1B(3), POLR1C(2), RAC1(10), RB1(9), TBX2(2), TP53(238), TWIST1(1)	9224538	407	249	238	13	50	78	55	71	145	8	<1.00e-15	2.11e-15	9.77e-14
14	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(9), ATR(19), BRCA1(9), CCNB1(3), CDC25B(3), CDC34(1), CHEK1(1), CHEK2(4), EP300(25), MDM2(2), MYT1(7), PRKDC(15), RPS6KA1(4), TP53(238), WEE1(1), YWHAH(1), YWHAQ(1)	19102840	343	231	248	25	53	50	66	65	102	7	6.77e-15	2.22e-15	9.77e-14
15	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), HRAS(11), IGF1R(7), IRS1(1), MAP2K1(4), MAPK1(4), PIK3CA(64), PIK3R1(6), RAF1(2), SHC1(1), SOS1(8), YWHAH(1)	8655628	112	93	63	5	11	50	23	23	5	0	1.87e-11	2.66e-15	1.07e-13
16	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(9), CDC25B(3), CDK4(4), CHEK1(1), MYT1(7), RB1(9), TP53(238), WEE1(1), YWHAH(1)	7991690	273	218	181	12	44	33	49	46	94	7	3.11e-15	3.11e-15	1.07e-13
17	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNG(1), IFNGR1(5), IFNGR2(2), IKBKB(5), JAK2(2), LIN7A(2), NFKB1(2), RB1(9), RELA(1), TP53(238), USH1C(2)	8287879	270	219	177	20	43	33	48	43	96	7	1.09e-13	3.33e-15	1.07e-13
18	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(9), ATM(9), ATR(19), BAI1(4), BAX(1), BID(2), CASP3(1), CASP8(25), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CCNG1(1), CCNG2(2), CDK4(4), CDK6(1), CDKN2A(61), CHEK1(1), CHEK2(4), DDB2(2), EI24(1), FAS(1), GADD45G(1), GTSE1(4), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(2), PTEN(6), RCHY1(1), RFWD2(1), RRM2(1), RRM2B(1), SERPINE1(4), SESN3(1), SFN(5), SIAH1(1), STEAP3(2), THBS1(7), TNFRSF10B(1), TP53(238), TSC2(3)	29795051	453	244	324	38	57	62	73	86	167	8	<1.00e-15	3.44e-15	1.07e-13
19	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(3), DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(2), NFKB1(2), RELA(1), TP53(238)	4476449	250	213	158	10	43	30	41	42	87	7	<1.00e-15	3.44e-15	1.07e-13
20	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(2), MAP2K4(1), MAP2K5(2), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(4), MAPK9(4), MYEF2(3), NFATC3(6), NR2C2(1), PAPPA(9), SHC1(1), TP53(238), TRAF6(1), ZAK(2)	22997165	328	225	236	30	52	50	70	53	96	7	3.01e-13	3.77e-15	1.07e-13
21	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(3), CCND1(2), CCNE1(3), CCNE2(3), CDK4(4), CDKN1B(2), CDKN2A(61), E2F2(3), E2F4(1), PRB1(8)	4091450	94	86	59	6	3	10	11	14	55	1	4.70e-07	3.89e-15	1.07e-13
22	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(11), AKT1(2), ATM(9), BAX(1), CPB2(3), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(2), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1), TP53(238)	9472034	277	214	185	19	45	34	54	47	90	7	5.32e-13	4.00e-15	1.07e-13
23	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(9), ATM(9), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK4(4), MDM2(2), RB1(9), TP53(238)	8248470	278	219	186	16	44	36	46	50	95	7	2.07e-14	4.11e-15	1.07e-13
24	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), CASP3(1), CASP6(2), CASP7(1), EIF2S1(1), PRKCA(2), PTK2(5), PXN(1), STAT1(5), TLN1(13), TP53(238)	12480574	296	229	204	26	48	40	58	51	92	7	9.48e-12	4.33e-15	1.07e-13
25	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(9), ATR(19), BRCA1(9), BRCA2(11), CHEK1(1), CHEK2(4), FANCA(4), FANCC(2), FANCD2(3), FANCG(2), HUS1(2), MRE11A(1), RAD17(3), RAD50(5), RAD51(1), TP53(238), TREX1(2)	20066645	316	226	224	20	47	50	56	61	95	7	4.27e-14	4.33e-15	1.07e-13
26	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(2), GH1(1), GHR(4), HRAS(11), IGF1R(7), PIK3CA(64), PIK3R1(6), SHC1(1), SOD2(1), SOD3(1)	6068225	100	85	54	5	8	49	18	23	2	0	2.99e-10	4.66e-15	1.10e-13
27	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(2), ANXA1(1), CALM1(1), CALM3(1), GNAS(6), GNB1(2), NFKB1(2), NOS3(4), NPPA(1), NR3C1(5), PIK3CA(64), PIK3R1(6), RELA(1), SYT1(5)	8161012	101	88	60	4	12	48	12	25	4	0	1.42e-10	5.11e-15	1.17e-13
28	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(15), HRAS(11), PAX3(4), PML(1), RARA(2), RB1(9), SIRT1(1), SP100(2), TP53(238)	8657665	283	228	186	22	44	35	57	44	96	7	1.98e-13	5.33e-15	1.17e-13
29	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3D(1), CD80(5), CD86(1), CTLA4(1), HLA-DRA(1), ICOS(1), ITK(1), LCK(5), PIK3CA(64), PIK3R1(6), PTPN11(1)	5827830	89	82	48	3	2	47	11	22	7	0	4.05e-10	5.77e-15	1.21e-13
30	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(9), BRCA1(9), CHEK1(1), CHEK2(4), MAPK8(4), MDM2(2), MRE11A(1), NFKB1(2), RAD50(5), RAD51(1), RBBP8(6), RELA(1), TP53(238)	13588317	283	218	191	20	45	40	53	49	89	7	2.99e-12	5.88e-15	1.21e-13
31	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(64), PIK3R1(6), PLCB1(12), PLCG1(5), PRKCA(2), VAV1(2)	5843024	93	85	52	6	4	46	19	22	2	0	1.69e-08	6.11e-15	1.21e-13
32	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), INSR(2), IRS1(1), MAP2K1(4), MAPK8(4), PIK3CA(64), PIK3R1(6), PTPN11(1), RAF1(2), RASA1(14), SHC1(1), SLC2A4(1), SOS1(8)	11617808	127	104	79	4	9	47	31	23	17	0	3.97e-13	7.33e-15	1.41e-13
33	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), HRAS(11), MAPK1(4), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NTRK1(3), PIK3CA(64), PIK3R1(6), PLCG1(5), RPS6KA1(4), SHC1(1)	8628815	112	95	63	6	10	52	21	24	5	0	2.16e-11	2.31e-14	4.31e-13
34	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(2), CDKN1B(2), ILK(4), ITGB1(12), MAPK1(4), PDPK1(2), PIK3CA(64), PIK3R1(6), PTEN(6), PTK2(5), SHC1(1), SOS1(8)	8837396	118	97	73	9	9	50	20	24	15	0	1.23e-08	1.60e-13	2.90e-12
35	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(4), DLL1(4), FURIN(1), NOTCH1(61)	4273951	70	66	70	6	13	12	11	7	27	0	1.16e-05	1.14e-12	1.99e-11
36	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(12), ARHGEF1(5), F2(2), F2RL3(3), GNA12(1), GNA13(1), GNAI1(1), GNB1(2), MAP3K7(4), PIK3CA(64), PIK3R1(6), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2B(2), ROCK1(11)	11794945	129	108	88	9	12	52	31	29	5	0	2.05e-10	1.16e-12	1.99e-11
37	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(7), HLA-A(9), ITGB1(12), KLRC2(1), KLRC3(2), KLRC4(1), LAT(3), MAP2K1(4), PAK1(1), PIK3CA(64), PIK3R1(6), PTK2B(2), PTPN6(1), RAC1(10), SYK(3), VAV1(2)	8470747	128	103	82	10	12	48	16	30	22	0	2.78e-09	1.66e-12	2.76e-11
38	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), PAK1(1), PDGFRA(6), PIK3CA(64), PIK3R1(6), RAC1(10), WASL(1)	6096912	94	80	51	8	5	47	13	25	4	0	1.52e-06	2.09e-12	3.39e-11
39	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(2), AKT2(3), AKT3(4), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CAPN2(4), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(25), CFLAR(2), CHUK(3), CSF2RB(5), FADD(1), FAS(1), FASLG(2), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IL3(1), IL3RA(3), IRAK1(2), IRAK2(2), IRAK3(4), IRAK4(3), MAP3K14(2), NFKB1(2), NFKB2(1), NTRK1(3), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TP53(238), TRAF2(1)	38083445	475	267	339	51	71	110	78	93	115	8	<1.00e-15	1.13e-11	1.79e-10
40	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), HRAS(11), MAPK1(4), NFKB1(2), PAK1(1), PIK3CA(64), PIK3R1(6), RAC1(10), RAF1(2), RB1(9), RELA(1), TFDP1(3)	9219962	127	104	76	10	11	54	19	28	15	0	5.53e-10	7.72e-11	1.19e-09
41	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(61), RB1(9), RBL1(8), TFDP1(3)	7297818	100	92	66	11	5	10	10	13	61	1	2.49e-05	1.02e-09	1.54e-08
42	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(6), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MPL(2), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4)	13650337	141	110	92	10	11	53	33	26	18	0	2.70e-10	8.57e-09	1.26e-07
43	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(3), AKT3(4), ELK1(1), HRAS(11), MAP2K1(4), MAP2K2(3), NGFR(1), NTRK1(3), PIK3CA(64), PIK3CD(2), SHC1(1), SOS1(8)	7364137	107	89	61	11	9	48	23	25	2	0	1.15e-07	1.04e-08	1.49e-07
44	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(12), AKT1(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), GNAS(6), HRAS(11), MAPK1(4), MAPK14(1), PIK3CA(64), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAC1(10), RPS6KA1(4), RPS6KA5(4), SOS1(8)	13246919	149	114	98	11	18	60	32	31	8	0	4.91e-11	3.37e-08	4.72e-07
45	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(15), EP300(25), FYN(3), IL7R(3), JAK1(6), JAK3(3), LCK(5), NMI(5), PIK3CA(64), PIK3R1(6), PTK2B(2), STAT5A(1), STAT5B(4)	12730011	143	114	99	13	7	61	25	35	15	0	5.97e-10	1.43e-07	1.93e-06
46	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(25), CFL1(2), CFLAR(2)	1766707	31	31	28	4	3	8	2	5	13	0	0.0150	1.44e-07	1.93e-06
47	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(2), AKT2(3), AKT3(4), BAD(1), BTK(5), CDKN2A(61), GSK3B(1), IARS(7), IGFBP1(2), INPP5D(7), PDK1(1), PIK3CA(64), PPP1R13B(1), PTEN(6), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SOS1(8), SOS2(9), TEC(2), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	16419845	216	156	141	28	11	65	42	40	57	1	7.66e-09	1.64e-07	2.15e-06
48	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PDGFRA(6), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1)	15891070	154	116	105	12	13	51	39	28	23	0	5.92e-10	2.63e-07	3.38e-06
49	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(12), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(2), ITGB3(5), MAPK1(4), PDGFRA(6), PIK3CA(64), PIK3R1(6), PLCB1(12), PRKCA(2), PTK2(5), RAC1(10), SMPD1(1), SMPD2(1), SRC(1)	12503964	137	113	91	13	15	53	31	29	9	0	4.43e-09	6.50e-07	8.17e-06
50	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BAX(1), BTK(5), CAD(2), CASP10(2), CASP3(1), CASP8(25), CASP8AP2(3), CD7(2), CSNK1A1(1), DEDD(1), DEDD2(2), DIABLO(1), EGFR(14), EPHB2(2), FADD(1), FAF1(1), IL1A(1), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MET(1), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR0B2(1), PTPN13(9), RALBP1(2), RIPK1(2), ROCK1(11), SMPD1(1), TNFRSF6B(2), TP53(238), TPX2(4), TRAF2(1)	33201124	383	237	285	44	61	57	82	62	114	7	1.06e-12	7.08e-07	8.72e-06
51	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(9), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), CASP8(25), GZMB(1), PRF1(3)	5879834	49	46	46	3	5	8	5	14	17	0	0.000438	1.01e-06	1.22e-05
52	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A1(1), EIF4B(2), EIF4EBP1(1), EIF4G1(14), EIF4G2(2), EIF4G3(4), MKNK1(1), PDPK1(2), PIK3CA(64), PIK3R1(6), PTEN(6), RPS6KB1(3), TSC1(2), TSC2(3)	12625922	113	95	71	8	1	52	25	22	13	0	1.93e-08	6.72e-06	7.97e-05
53	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NFKB1(2), PIK3CA(64), PIK3R1(6), RB1(9), RELA(1), SP1(1)	8844809	105	94	61	11	9	46	14	22	14	0	4.97e-06	7.65e-06	8.90e-05
54	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(4), HRAS(11), INSR(2), IRS1(1), JAK2(2), MAP2K1(4), MAPK1(4), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(8), STAT5A(1), STAT5B(4)	15069480	128	100	79	8	13	57	28	24	6	0	4.58e-12	9.19e-06	0.000105
55	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF4EBP1(1), GSK3B(1), IGF1R(7), INPPL1(4), PDPK1(2), PIK3CA(64), PIK3R1(6), PTEN(6), RPS6KB1(3)	9000539	101	87	59	10	7	48	17	21	8	0	5.24e-07	1.40e-05	0.000156
56	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(6), EGF(6), EGFR(14), ELK1(1), FOS(1), HRAS(11), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1)	17057685	168	126	119	16	14	55	42	33	24	0	2.87e-09	1.73e-05	0.000190
57	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(12), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(5), IGF1R(7), IL3(1), IL3RA(3), KIT(5), PIK3CA(64), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), YWHAH(1)	10001758	119	98	78	14	11	55	20	28	5	0	1.19e-07	2.31e-05	0.000249
58	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNG(4), MUSK(6), PIK3CA(64), PIK3R1(6), PTK2(5), PTK2B(2), SRC(1), TERT(1), YWHAH(1)	7476640	93	87	52	12	4	46	13	24	6	0	2.98e-06	2.44e-05	0.000259
59	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(3), AKT3(4), BPNT1(1), ILK(4), MAPK1(4), PDK1(1), PIK3CA(64), PIK3CD(2), PTEN(6), PTK2B(2), RBL2(3), SHC1(1), SOS1(8)	9323850	105	88	61	12	7	47	22	23	6	0	1.17e-06	0.000104	0.00108
60	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIK(1), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(25), DIABLO(1)	6118191	48	47	45	4	5	10	7	9	17	0	0.00143	0.000145	0.00149
61	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(9), CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CCNE2(3), CCNG2(2), CDK4(4), CDKN1B(2), CDKN2A(61), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F2(3), E2F4(1), E2F5(4), E2F6(1), GBA2(3), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MNAT1(2), MYC(4), MYT1(7), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(1), POLE(8), POLE2(1), RB1(9), RBL1(8), RPA1(4), TFDP1(3), TFDP2(1), TNXB(10), TP53(238), WEE1(1)	35142210	437	239	310	55	60	58	86	71	154	8	3.80e-13	0.000159	0.00160
62	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM3(1), CD3D(1), ELK1(1), FOS(1), FYN(3), HRAS(11), LAT(3), LCK(5), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN7(2), RAC1(10), RAF1(2), RASA1(14), RELA(1), SHC1(1), SOS1(8), SYT1(5), VAV1(2), ZAP70(2)	21806921	186	130	136	16	24	61	45	37	19	0	1.65e-11	0.000213	0.00211
63	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(1), CRKL(1), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), MYC(4), PIK3CA(64), PIK3R1(6), RAF1(2), SOS1(8), STAT1(5), STAT5A(1), STAT5B(4)	12830026	125	100	79	12	8	55	30	23	9	0	2.49e-08	0.000380	0.00372
64	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), CRK(1), CRKL(1), DOCK1(8), ELK1(1), FOS(1), GAB1(2), HGF(8), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAP2K2(3), MAP4K1(2), MAPK1(4), MAPK8(4), MET(1), PAK1(1), PIK3CA(64), PIK3R1(6), PTEN(6), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAF1(2), RAP1B(2), RASA1(14), SOS1(8), SRC(1), STAT3(3)	20079123	184	137	130	20	21	55	45	39	24	0	1.59e-08	0.000438	0.00422
65	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(9), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP7(1), CASP8(25), GZMB(1), PRF1(3), SCAP(1), SREBF1(3), SREBF2(4)	8296936	52	48	49	3	7	8	9	11	17	0	0.000135	0.00304	0.0288
66	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), KEAP1(13), MAPK1(4), MAPK14(1), MAPK8(4), NFE2L2(18), PRKCA(2)	4056446	44	39	36	6	8	6	20	7	3	0	0.0195	0.00782	0.0730
67	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(2), EIF4G3(4), GHR(4), IRS1(1), MAPK1(4), MAPK14(1), MKNK1(1), PDPK1(2), PIK3CA(64), PIK3R1(6), PRKCA(2), PTEN(6), RPS6KB1(3)	12861161	118	98	73	11	4	55	23	24	12	0	2.32e-07	0.0115	0.106
68	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(5), CALM1(1), CALM3(1), ELK1(1), FCER1A(2), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PAK2(5), PIK3CA(64), PIK3R1(6), PLA2G4A(3), PLCG1(5), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2)	19606400	166	120	117	17	22	57	40	33	14	0	6.85e-09	0.0134	0.121
69	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(4), BIRC3(1), CASP8(25), FADD(1), RIPK1(2), TRAF2(1)	3830042	34	33	31	5	3	7	6	5	13	0	0.0227	0.0499	0.446
70	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(2), CFLAR(2), CRKL(1), FOS(1), HRAS(11), IL2RA(2), IL2RB(3), IRS1(1), JAK1(6), JAK3(3), MAPK1(4), MYC(4), NMI(5), PIK3CA(64), PIK3R1(6), PTPN6(1), RAF1(2), RPS6KB1(3), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3)	16459868	144	108	95	15	15	60	32	28	9	0	1.18e-09	0.0510	0.449
71	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(3), CYP2C9(5)	922599	8	8	8	0	0	3	4	1	0	0	0.0867	0.0521	0.452
72	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(6), FYN(3), GSN(5), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAPK1(4), MYLK(4), PIK3CA(64), PIK3R1(6), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SRC(1), TLN1(13)	17023753	162	118	112	21	17	58	36	40	11	0	8.56e-07	0.0995	0.837
73	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CUL1(6), FBXW7(14), RB1(9), TFDP1(3)	3734402	36	31	34	5	5	6	7	5	13	0	0.0424	0.0996	0.837
74	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAI1(1), GNB1(2), HRAS(11), MAP2K1(4), MAPK1(4), NFKB1(2), PIK3C2G(7), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PTK2B(2), PXN(1), RAF1(2), RELA(1)	12614453	124	99	75	17	14	50	26	25	9	0	4.97e-06	0.101	0.837
75	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	231812	2	2	2	0	0	0	0	0	2	0	0.660	0.120	0.985
76	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(9), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(25), GZMB(1), LMNB1(1), LMNB2(4), PRF1(3)	8796163	54	52	51	6	8	9	9	12	16	0	0.00300	0.128	1.000
77	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(12), GNAS(6), GNB1(2), PRKACA(4), PRKAR1A(2)	2991458	26	23	26	2	10	3	9	4	0	0	0.0192	0.155	1.000
78	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(1), FUT1(1), FUT2(2), FUT9(10), GCNT2(4), ST8SIA1(2)	2797416	22	21	22	4	2	7	10	2	1	0	0.124	0.182	1.000
79	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(4), APC(15), AXIN1(5), BTRC(1), CTNNB1(2), DLL1(4), DVL1(2), FZD1(3), GSK3B(1), NOTCH1(61), WNT1(1)	9819392	99	79	99	15	15	20	20	13	30	1	0.00102	0.253	1.000
80	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(5), PTGS1(6), PTGS2(2)	2433197	17	15	17	2	2	1	9	0	5	0	0.159	0.261	1.000
81	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(6), ELK1(1), EPO(2), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MAPK8(4), PLCG1(5), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4)	9768227	53	46	48	4	9	9	25	2	8	0	0.000412	0.297	1.000
82	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	829283	5	5	5	1	1	2	0	1	1	0	0.394	0.323	1.000
83	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), ACADS(2), ECHS1(2), HADHA(3)	2467452	12	12	12	1	2	2	4	3	1	0	0.127	0.339	1.000
84	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR0B2(1), NR1H4(5), RXRA(4)	2480469	15	15	15	1	2	2	6	1	4	0	0.104	0.397	1.000
85	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(4), KERA(4)	1651973	10	8	10	2	0	4	5	0	1	0	0.317	0.454	1.000
86	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(4)	1362330	8	8	8	2	1	2	0	4	1	0	0.515	0.462	1.000
87	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(7), COPS5(1), CREB1(1), EP300(25), EPO(2), HIF1A(2), LDHA(1), NOS3(4), P4HB(1)	7747043	48	46	45	6	11	11	9	8	9	0	0.00613	0.469	1.000
88	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1)	2786733	13	11	13	0	1	4	4	3	1	0	0.0325	0.494	1.000
89	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(10)	1693069	11	11	11	2	1	2	8	0	0	0	0.287	0.499	1.000
90	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(3), UXS1(1)	1758796	7	7	7	0	0	1	3	3	0	0	0.188	0.556	1.000
91	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IL6R(4), IL6ST(2), JAK1(6), JAK2(2), JAK3(3), MAP2K1(4), PTPN11(1), RAF1(2), SHC1(1), SOS1(8), STAT3(3)	10836566	56	50	50	6	8	7	23	8	10	0	0.00433	0.558	1.000
92	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(5), RXRA(4)	2635335	11	11	11	0	2	1	4	2	2	0	0.0436	0.561	1.000
93	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA6(1), PSMB10(3), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMB8(1)	3977611	17	16	17	0	0	4	6	4	3	0	0.0122	0.580	1.000
94	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(2), CHST13(3), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1)	4218503	21	19	21	2	3	4	6	6	2	0	0.0500	0.581	1.000
95	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HBXIP(1), HRAS(11), PTK2B(2), SHC1(1), SOS1(8), SRC(1)	4021884	25	23	20	4	5	4	11	3	2	0	0.136	0.601	1.000
96	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(9), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCNE1(3), CCNE2(3), CDAN1(7), CDC14A(2), CDC20(2), CDC25B(3), CDC6(2), CDC7(1), CDH1(4), CDK4(4), CDKN2A(61), CHEK1(1), CHEK2(4), DTX4(3), E2F2(3), E2F4(1), E2F5(4), E2F6(1), EP300(25), ESPL1(9), GSK3B(1), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), HDAC8(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MPEG1(1), MPL(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PLK1(2), PRKDC(15), PTPRA(4), RB1(9), RBL1(8), SKP2(2), SMAD4(8), TBC1D8(2), TFDP1(3), TGFB1(1), TP53(238), WEE1(1)	50036274	512	255	383	70	71	78	98	83	174	8	2.52e-13	0.642	1.000
97	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), PSMD14(2), RPN1(1), RPN2(2), UBE3A(4)	5879770	23	22	23	1	0	5	8	7	3	0	0.0157	0.685	1.000
98	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(15), AXIN1(5), CCND1(2), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(2), LBP(7), LEF1(2), LY96(1), NFKB1(2), PDPK1(2), PIK3CA(64), PIK3R1(6), RELA(1), TLR4(7), WNT1(1)	14054248	130	106	89	23	9	58	25	30	7	1	0.000107	0.686	1.000
99	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(6), BCMO1(2)	1777605	8	8	8	2	2	1	2	1	2	0	0.458	0.686	1.000
100	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(4), RDH11(1), RDH12(3)	2186793	11	10	11	2	2	2	5	2	0	0	0.279	0.687	1.000
101	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(3), UGP2(1), UXS1(1)	2237857	8	8	8	0	0	1	4	3	0	0	0.158	0.689	1.000
102	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), HRAS(11), MAP2K1(4), MAPK1(4), MYC(4), NFKB1(2), PLCB1(12), PRKCA(2), RAF1(2), RELA(1)	7091847	46	44	38	8	10	8	20	5	3	0	0.0284	0.689	1.000
103	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(4), EIF1(2), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(2), ELAVL1(1), FLT1(10), FLT4(6), HIF1A(2), HRAS(11), KDR(5), NOS3(4), PIK3CA(64), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PXN(1), SHC1(1)	15483194	138	108	92	22	18	54	34	25	7	0	3.32e-05	0.690	1.000
104	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(3), MAPK14(1), THBS1(7)	3373854	13	12	13	1	0	4	4	4	1	0	0.0798	0.691	1.000
105	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(4), FYN(3), LRP8(1), RELN(37), VLDLR(1)	6372797	46	39	44	7	5	5	13	15	8	0	0.0993	0.691	1.000
106	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	752631	2	2	2	0	1	1	0	0	0	0	0.450	0.693	1.000
107	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), HRAS(11), MAP2K1(4), MAP2K2(3), MAPK1(4), NGFR(1), RAF1(2)	3712483	28	26	20	6	9	3	10	2	4	0	0.121	0.701	1.000
108	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2)	2580190	11	10	11	1	1	3	3	1	3	0	0.138	0.710	1.000
109	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	1018738	3	3	3	1	1	1	1	0	0	0	0.607	0.729	1.000
110	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), HLA-DRA(1)	1077093	3	3	3	1	0	1	0	1	1	0	0.732	0.730	1.000
111	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IL2RA(2), IL2RB(3), JAK1(6), JAK3(3), LCK(5), MAP2K1(4), MAPK8(4), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3)	10601580	65	53	60	9	9	11	27	6	12	0	0.00383	0.736	1.000
112	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(2), IDI1(1)	1460995	6	6	6	2	2	3	1	0	0	0	0.481	0.758	1.000
113	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3)	2211166	7	7	7	0	0	1	1	3	2	0	0.159	0.758	1.000
114	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(12), CAP1(2), CCNB1(3), GNAI1(1), GNAS(6), GNB1(2), HRAS(11), MAPK1(4), MYT1(7), PIN1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(4), SRC(1)	9339279	64	57	56	9	20	11	21	10	2	0	0.00160	0.760	1.000
115	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2)	2570828	13	12	13	3	1	5	1	3	3	0	0.407	0.767	1.000
116	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(64), PIK3CD(2), PIK3R1(6), SYT1(5), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	15339814	122	102	78	19	14	48	24	26	10	0	8.40e-06	0.777	1.000
117	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(9), SP1(1), SP3(1)	3024881	13	13	13	3	0	1	1	2	9	0	0.581	0.781	1.000
118	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(4)	2142884	16	15	16	4	2	2	8	1	3	0	0.440	0.782	1.000
119	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	695872	1	1	1	0	0	0	0	1	0	0	0.757	0.790	1.000
120	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB1A(1), RAB3A(1), RAB5A(2)	1919717	6	6	6	0	2	2	1	1	0	0	0.115	0.795	1.000
121	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), HRAS(11), IL3(1), IL3RA(3), JAK2(2), MAP2K1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4)	8056065	44	39	39	6	7	12	17	4	4	0	0.00826	0.815	1.000
122	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDC34(1), CUL1(6), RB1(9), SKP2(2), TFDP1(3)	3866305	28	26	28	7	4	4	5	3	12	0	0.335	0.822	1.000
123	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(1), ADORA3(2), LTB4R(2), P2RY1(4), P2RY2(2), P2RY6(2)	2718389	17	15	17	4	4	5	6	2	0	0	0.127	0.828	1.000
124	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(2), PRKCA(2), TGM2(3)	2255806	8	8	8	1	0	3	3	2	0	0	0.172	0.833	1.000
125	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDKN1B(2), CKS1B(1), CUL1(6), NEDD8(1), RB1(9), RBX1(2), SKP2(2), TFDP1(3)	3895401	29	28	29	7	3	5	5	4	12	0	0.277	0.839	1.000
126	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(1), HLA-DRA(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL2RA(2), IL4(1), IL4R(2)	5765533	34	31	33	5	3	9	9	6	7	0	0.0366	0.846	1.000
127	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), REG1A(8), SOAT1(3)	6236900	32	31	32	4	4	6	11	5	6	0	0.0445	0.847	1.000
128	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(9), EPHB1(9), FYN(3), ITGA1(3), ITGB1(12), L1CAM(3), LYN(3), RAP1B(2), SELP(11)	7201984	57	43	56	9	8	11	13	14	11	0	0.0272	0.847	1.000
129	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(3), ALDOC(1), TPI1(2)	1785922	7	7	7	2	1	2	2	2	0	0	0.543	0.847	1.000
130	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(3), SNCAIP(1), UBE2L3(1), UBE2L6(1)	2927495	11	10	11	2	1	2	2	4	2	0	0.360	0.849	1.000
131	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3)	3564134	10	10	10	1	1	2	1	4	2	0	0.182	0.855	1.000
132	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(1), STX1A(3)	1483617	4	4	4	1	1	0	1	1	1	0	0.756	0.858	1.000
133	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(15), CDH1(4), CREBBP(15), EP300(25), MAP2K1(4), MAP3K7(4), SKIL(4), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11)	11685351	86	74	81	13	10	16	25	15	20	0	0.0156	0.862	1.000
134	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CA(64), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4)	20405654	166	122	124	26	22	56	37	38	12	1	2.24e-06	0.877	1.000
135	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	516198	1	1	1	0	0	0	1	0	0	0	0.843	0.890	1.000
136	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(1), IFNGR1(5), JAK1(6), JAK2(2), PTPRU(6), REG1A(8), STAT1(5)	5208584	34	31	33	6	4	8	9	4	9	0	0.0651	0.899	1.000
137	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(3), TAT(1)	1197770	5	5	5	2	1	0	3	1	0	0	0.740	0.899	1.000
138	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(1), OXCT1(1)	1542084	3	3	3	1	1	0	0	1	1	0	0.692	0.909	1.000
139	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), IFNG(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TGFBR3(3), TOB2(2)	4814025	27	25	25	5	2	6	4	6	9	0	0.188	0.911	1.000
140	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(7), IFNAR1(2), IFNAR2(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1)	5062810	22	22	22	4	3	4	5	6	4	0	0.303	0.914	1.000
141	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(2), IDI1(1)	1951946	6	6	6	2	2	3	1	0	0	0	0.482	0.915	1.000
142	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(5), IFNGR2(2), JAK1(6), JAK2(2), STAT1(5)	3727435	21	20	20	6	1	5	4	2	9	0	0.406	0.919	1.000
143	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(2), HDC(2), PNMT(1), TH(2), TPH1(2)	2763324	13	13	13	3	2	1	6	1	3	0	0.476	0.926	1.000
144	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD80(5), HLA-DRA(1), IL4(1)	1807437	9	9	9	3	0	4	2	2	1	0	0.525	0.927	1.000
145	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3), AOC2(2), AOC3(5), CES1(4), ESD(1)	2756712	15	15	15	4	1	6	6	0	2	0	0.320	0.934	1.000
146	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(2), CD3D(1)	1461751	3	3	3	1	0	0	1	1	1	0	0.841	0.934	1.000
147	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR2(5), MTMR6(2), NFS1(1), PHPT1(1), TPK1(3)	2920637	13	11	13	3	3	2	3	3	2	0	0.484	0.945	1.000
148	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(3), CHEK1(1), NEK1(3), WEE1(1)	3132462	8	8	8	1	2	1	4	0	1	0	0.556	0.947	1.000
149	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PCYT1A(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2)	6395286	28	26	28	4	9	7	7	2	3	0	0.0385	0.947	1.000
150	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(2), SRP19(2), SRP68(2), SRPR(2)	3433083	9	8	9	1	0	2	4	2	1	0	0.349	0.949	1.000
151	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(12), TUB(2)	3252404	17	17	17	4	5	3	7	2	0	0	0.298	0.951	1.000
152	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(1), GPI(2), HK1(3), PFKL(4), PGAM1(1), PKLR(1), TPI1(2)	4218425	17	16	17	3	6	3	1	4	3	0	0.215	0.951	1.000
153	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2)	3809273	11	11	11	2	1	1	3	4	2	0	0.369	0.957	1.000
154	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1)	3173054	8	8	8	1	1	3	2	1	1	0	0.257	0.964	1.000
155	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2RL3(3), GNAI1(1), GNB1(2), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAPK1(4), PLA2G4A(3), PLCB1(12), PRKCA(2), PTGS1(6), PTK2(5), RAF1(2), SRC(1), SYK(3), TBXAS1(5)	11108969	81	65	72	13	17	10	29	13	12	0	0.00746	0.965	1.000
156	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), PRKCE(2)	3578364	31	28	31	9	2	6	12	5	6	0	0.476	0.966	1.000
157	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), HLA-DRA(1), IL1B(1), IL4(1), IL5(1), IL5RA(1)	2426471	8	8	8	2	0	4	4	0	0	0	0.379	0.973	1.000
158	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(4), CD3D(1), CD8A(2), IL3(1)	2820651	9	9	9	3	2	1	2	1	3	0	0.618	0.976	1.000
159	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CTH(2), MUT(2)	2232722	8	7	8	2	0	4	3	0	1	0	0.464	0.978	1.000
160	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1)	4056012	15	13	15	3	1	5	6	2	1	0	0.274	0.984	1.000
161	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(1), BCL2(1), CASP8(25), FADD(1), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(2), SMPD1(1), TRAF2(1)	9375042	57	52	51	10	11	7	14	8	17	0	0.0348	0.985	1.000
162	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), ST3GAL3(1)	2320444	10	10	10	3	2	3	2	1	2	0	0.446	0.985	1.000
163	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), AVP(1), CABIN1(7), CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(7), INSR(2), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NFATC1(7), NFATC2(6), PIK3CA(64), PIK3R1(6), SYT1(5), YWHAH(1)	15890207	126	103	85	25	11	54	24	31	6	0	0.000137	0.985	1.000
164	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6R(4), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), REG1A(8), SRC(1), STAT3(3)	6925632	37	36	36	6	5	6	12	9	5	0	0.0586	0.986	1.000
165	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(1), ATF1(2), BRAF(4), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(1), EGR1(3), EGR2(1), ELK1(1), MAP1B(12), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(7), PIK3CA(64), PIK3CD(2), PIK3R1(6), PTPN11(1), RPS6KA3(3), SHC1(1), SRC(1), TH(2)	23421397	167	125	123	29	16	63	40	32	16	0	2.83e-05	0.986	1.000
166	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4)	6131663	23	22	23	4	2	5	10	2	4	0	0.131	0.990	1.000
167	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST8SIA1(2)	4897881	28	25	28	6	1	5	13	4	5	0	0.240	0.990	1.000
168	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(12), FHL5(4), FSHB(1), FSHR(5), GNAS(6), XPO1(3)	4347116	31	29	31	6	8	6	10	7	0	0	0.199	0.993	1.000
169	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	CS(2), MDH1(1), ME1(1), PC(7), PDHA1(3), SLC25A1(1)	4234898	15	15	15	4	3	5	3	3	1	0	0.375	0.995	1.000
170	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), ITPKA(1), ITPKB(5)	2748280	8	6	8	2	2	2	2	2	0	0	0.361	0.995	1.000
171	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(2), GLB1(4), HEXA(3), LCT(8), SLC33A1(1), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4)	7487856	40	35	40	8	7	10	10	9	4	0	0.0779	0.995	1.000
172	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(3), AKT3(4), BRD4(5), CAP1(2), CBL(2), CDC42(1), CDKN2A(61), F2RL2(1), FLOT1(1), FLOT2(3), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), LNPEP(2), MAPK1(4), PARD3(10), PARD6A(1), PDK1(1), PIK3CA(64), PIK3CD(2), PIK3R1(6), PPYR1(1), PTEN(6), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SERPINB6(3), SFN(5), SHC1(1), SLC2A4(1), SORBS1(2), SOS1(8), SOS2(9), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	27146454	257	173	178	39	26	70	50	45	65	1	6.71e-09	0.996	1.000
173	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(2), OXCT1(1), OXCT2(1)	3277286	10	9	10	3	3	1	2	3	1	0	0.569	0.996	1.000
174	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(11), MEF2A(1), MEF2B(2), MEF2C(7), YWHAH(1)	3486563	24	22	24	7	3	5	10	3	3	0	0.440	0.996	1.000
175	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), KARS(2)	2143652	6	6	6	3	0	1	1	2	2	0	0.863	0.996	1.000
176	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(10), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2)	4572101	16	14	16	3	2	9	3	2	0	0	0.127	0.997	1.000
177	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(1), DUSP14(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), MYOG(3), NR4A3(2)	4869061	17	15	17	3	2	5	4	5	1	0	0.236	0.997	1.000
178	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2)	4614870	28	25	28	7	1	6	12	4	5	0	0.318	0.997	1.000
179	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(2), ANGPTL2(2), DAG1(1), DGKA(2), ETFA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), MAP2K1(4), MAPK1(4), PAK1(1), PDE3A(13), PDE3B(1), PI3(1), PIK3C2G(7), PIK3CA(64), PIK3CD(2), PIK3R1(6), PLDN(2), PSME1(1), SGCB(3), VASP(1)	22099097	153	111	109	25	15	58	30	32	18	0	9.51e-06	0.997	1.000
180	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(15), NRG2(4), NRG3(8), PRKCA(2)	4087307	33	28	33	9	4	5	13	8	3	0	0.481	0.997	1.000
181	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5)	2209291	5	4	5	2	1	2	1	1	0	0	0.737	0.998	1.000
182	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(3)	3118783	13	13	13	4	4	0	7	2	0	0	0.578	0.998	1.000
183	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(2), AFMID(3), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	6097801	28	24	28	5	3	6	9	6	4	0	0.148	0.999	1.000
184	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	2852136	4	4	4	1	0	1	2	1	0	0	0.693	0.999	1.000
185	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(2), GGT1(1)	2616298	10	10	10	4	2	3	1	1	3	0	0.701	0.999	1.000
186	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(1), IL12A(1), IL12B(4), IL13(1), IL16(11), IL1A(1), IL3(1), IL4(1), IL5(1), IL9(1), LTA(1)	4526342	24	22	24	7	8	6	4	5	1	0	0.290	0.999	1.000
187	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(21), MAP2(13), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(2)	8254538	41	34	41	8	2	6	14	8	11	0	0.373	0.999	1.000
188	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F3(1), F5(12), F7(2), FGA(7), FGB(2), FGG(3), PROS1(5), SERPINC1(3)	7476710	40	33	40	8	2	9	16	6	7	0	0.118	0.999	1.000
189	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), GSK3B(1), IL4R(2), IRS1(1), IRS2(2), JAK1(6), JAK3(3), MAP4K1(2), MAPK1(4), PDK1(1), PIK3CA(64), PIK3CD(2), PIK3R1(6), PPP1R13B(1), RAF1(2), SHC1(1), SOS1(8), SOS2(9), STAT6(2)	16670911	128	97	84	23	11	55	27	29	6	0	8.60e-05	0.999	1.000
190	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(2), ST3GAL3(1), ST3GAL4(1)	3283505	12	11	12	5	2	2	4	0	4	0	0.826	0.999	1.000
191	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(3), KARS(2)	3161374	9	9	9	4	0	1	2	3	3	0	0.830	0.999	1.000
192	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(6), EGFR(14), HRAS(11), MAP2K1(4), MAPK1(4), PTPRB(11), RAF1(2), RASA1(14), SHC1(1), SOS1(8), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), SRC(1)	11371632	83	74	73	16	13	13	29	14	14	0	0.0378	0.999	1.000
193	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(8), MBTPS2(1), SCAP(1), SREBF1(3), SREBF2(4)	5420463	22	20	22	5	2	4	8	5	3	0	0.348	0.999	1.000
194	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(2), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	5821305	25	22	25	5	3	6	8	5	3	0	0.190	0.999	1.000
195	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(9), HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(2)	3689804	17	16	17	5	2	4	6	4	1	0	0.478	0.999	1.000
196	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(1), COQ6(1), COQ7(1), NDUFA12(1), NDUFA13(2)	1824339	6	6	6	4	0	2	2	1	1	0	0.934	0.999	1.000
197	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(9), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(25), CFLAR(2), CHUK(3), FADD(1), GAS2(1), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1)	15233085	75	64	72	10	13	15	15	12	20	0	0.000878	0.999	1.000
198	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6)	3846743	7	7	7	2	2	0	2	1	2	0	0.730	1.000	1.000
199	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), ATM(9), ATR(19), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CDC14A(2), CDC16(1), CDC20(2), CDC23(1), CDC25B(3), CDC27(5), CDC6(2), CDC7(1), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(61), CHEK1(1), CHEK2(4), CREBBP(15), CUL1(6), E2F2(3), EP300(25), ESPL1(9), FZR1(2), GADD45G(1), GSK3B(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(15), RB1(9), RBL1(8), RBL2(3), RBX1(2), SFN(5), SKP1(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(8), SMC1A(3), SMC1B(5), TFDP1(3), TGFB1(1), TGFB2(2), TP53(238), WEE1(1), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	61936726	570	260	441	81	72	93	112	102	183	8	6.50e-13	1.000	1.000
200	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), FYN(3), HLA-DRA(1), LCK(5), PTPRC(13), ZAP70(2)	4113288	25	21	25	8	2	6	5	7	5	0	0.392	1.000	1.000
201	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25B(3), CSK(1), PRKCA(2), PTPRA(4), SRC(1)	4193055	14	13	14	4	4	3	6	1	0	0	0.361	1.000	1.000
202	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(1), BRAF(4), CREB1(1), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(1), EEF2K(4), MAP2K1(4), MAP2K2(3), MAP3K8(1), MAPK1(4), MKNK1(1), MKNK2(1), MOS(5), NFKB1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(8), SOS2(9), TRAF3(3)	13427113	75	56	71	11	15	15	23	12	10	0	0.00453	1.000	1.000
203	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(1), LDLR(3), LPL(2)	2422249	8	8	8	4	1	1	4	1	1	0	0.853	1.000	1.000
204	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(2), EDNRB(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	9389909	44	35	43	8	11	5	11	8	9	0	0.0441	1.000	1.000
205	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(9), BAD(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), CASP8AP2(3), CES1(4)	4964296	25	23	25	6	3	8	6	4	4	0	0.362	1.000	1.000
206	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(14), ERBB3(7), NRG1(1)	4690084	28	25	28	8	4	6	8	7	3	0	0.420	1.000	1.000
207	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(12), CFTR(7), GNAS(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(1)	5944860	34	30	34	8	10	6	12	6	0	0	0.200	1.000	1.000
208	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3)	3002239	17	17	17	6	3	2	6	3	3	0	0.516	1.000	1.000
209	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3)	3002239	17	17	17	6	3	2	6	3	3	0	0.516	1.000	1.000
210	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(1), FARS2(2), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3)	3783264	16	13	16	7	1	4	5	3	3	0	0.739	1.000	1.000
211	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(3), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	3610573	11	10	11	4	2	2	2	2	3	0	0.692	1.000	1.000
212	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(5), PRKCA(2), PTK2B(2)	3053975	11	11	11	4	2	2	5	2	0	0	0.492	1.000	1.000
213	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(4), CHPF(4), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHSY1(2), UST(1), XYLT1(7), XYLT2(3)	6353940	30	29	30	7	6	2	12	6	4	0	0.247	1.000	1.000
214	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(2), CSF1(1), EPO(2), IL3(1), IL4(1), IL5(1), IL9(1)	2773360	9	9	9	7	4	1	2	1	1	0	0.944	1.000	1.000
215	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1)	4623164	12	11	12	4	2	1	4	2	3	0	0.599	1.000	1.000
216	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(6), GNB1(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2)	4344323	20	17	20	5	8	5	5	2	0	0	0.279	1.000	1.000
217	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM3(1), CCL2(2), CXCL12(1), CXCR4(1), FOS(1), MAPK14(1), MAPK8(4), PLCG1(5), PRKCA(2), PTK2B(2), SYT1(5)	6275083	26	22	26	6	3	3	14	5	1	0	0.291	1.000	1.000
218	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), TYR(4)	4427430	24	22	24	8	2	4	13	1	4	0	0.734	1.000	1.000
219	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), DHRS1(1), DHRS2(3), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2)	6838421	31	29	31	8	8	8	8	4	3	0	0.199	1.000	1.000
220	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(1), ALOX15B(2), ALOX5(2), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	6863320	27	25	27	6	5	4	9	4	5	0	0.112	1.000	1.000
221	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CDC25B(3), MNAT1(2), XPO1(3)	3932458	11	11	11	4	4	3	2	2	0	0	0.593	1.000	1.000
222	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(14), ELK1(1), GNAS(6), GNB1(2), HRAS(11), IGF1R(7), ITGB1(12), MAP2K1(4), MAP2K2(3), MAPK1(4), MKNK1(1), MKNK2(1), MYC(4), NGFR(1), PDGFRA(6), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(3)	15030150	104	77	94	18	24	16	36	16	12	0	0.00424	1.000	1.000
223	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(3), CTH(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(6), MARS(2), MARS2(4), MAT1A(1), METTL2B(2), METTL6(2), PAPSS1(3), PAPSS2(3), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SEPHS1(1), SEPHS2(3)	11353289	47	39	46	8	12	13	13	5	4	0	0.0179	1.000	1.000
224	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2)	3636958	11	11	11	7	3	1	3	1	3	0	0.921	1.000	1.000
225	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2)	3636958	11	11	11	7	3	1	3	1	3	0	0.921	1.000	1.000
226	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALT2(3), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GCNT2(4), ST3GAL6(1), ST8SIA1(2)	7367361	37	33	37	9	4	12	14	3	4	0	0.120	1.000	1.000
227	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(3), AKT3(4), BCR(1), BTK(5), CD19(2), CDKN2A(61), FLOT1(1), FLOT2(3), GAB1(2), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), NR0B2(1), PDK1(1), PIK3CA(64), PITX2(1), PLCG2(4), PPP1R13B(1), PREX1(6), PTEN(6), PTPRC(13), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SYK(3), TEC(2), VAV1(2)	25067193	230	158	155	40	14	71	31	45	68	1	6.52e-08	1.000	1.000
228	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(12), CALM1(1), CALM3(1), CREB1(1), ELK1(1), FOS(1), GNAI1(1), GNAS(6), GNB1(2), HRAS(11), MAP2K1(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(2), RPS6KA3(3), SYT1(5)	15869077	87	67	82	14	24	16	29	13	5	0	0.00128	1.000	1.000
229	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), DHFR(3), FPGS(2)	2971869	15	13	15	6	2	1	9	2	1	0	0.682	1.000	1.000
230	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(15), EP300(25), ESR1(3), MAPK1(4), PELP1(1), SRC(1)	6706886	49	47	43	12	6	11	13	9	10	0	0.184	1.000	1.000
231	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(15), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1)	4837360	22	21	22	7	3	4	8	5	2	0	0.581	1.000	1.000
232	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(15), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(1), EPHB2(2), FOS(1), ITPKA(1), ITPKB(5), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4)	12987964	62	50	59	10	12	13	20	8	9	0	0.0154	1.000	1.000
233	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(7), ACO2(2), ACSS1(5), ACSS2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1)	6056947	22	19	22	6	2	6	7	3	4	0	0.403	1.000	1.000
234	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(3), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF13B(2), TNFRSF13C(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	6641117	25	25	24	7	2	5	10	1	7	0	0.598	1.000	1.000
235	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(2), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), NAGS(2), ODC1(1), OTC(1), PYCR1(1), SMS(2)	7984329	33	31	33	7	7	9	10	7	0	0	0.105	1.000	1.000
236	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(2), SDHA(5), SDHC(1), UQCRC1(1)	3015547	9	8	9	4	0	1	4	3	1	0	0.794	1.000	1.000
237	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(3), CHEK1(1), MYT1(7), WEE1(1), YWHAH(1)	6259861	22	21	22	5	3	2	9	6	2	0	0.549	1.000	1.000
238	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), AGT(2), AGTR2(2), EDNRB(3), EGF(6), EGFR(14), FOS(1), HRAS(11), MYC(4), NFKB1(2), PLCG1(5), PRKCA(2), RELA(1)	9370753	59	52	54	13	7	12	25	11	4	0	0.0623	1.000	1.000
239	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(2), NAT1(1), XDH(3)	3638553	12	11	12	5	1	2	4	3	2	0	0.753	1.000	1.000
240	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(2), DHFR(3), HPRT1(1), IMPDH1(3), MTHFD2(1), OAZ1(1), POLB(1), POLD1(3), POLG(2), PRPS2(1), RRM1(1)	5688117	23	21	23	6	5	3	12	0	3	0	0.292	1.000	1.000
241	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(1), IL1B(1), MST1(5), MST1R(5)	2968399	14	13	13	6	3	3	7	0	1	0	0.706	1.000	1.000
242	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADHA(3), HADHB(2), HSD17B4(3), PPT1(1), PPT2(1)	3860702	13	13	13	5	0	2	3	6	2	0	0.728	1.000	1.000
243	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(6), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF5(2), GSK3B(1)	5274480	15	14	15	8	3	3	5	0	4	0	0.953	1.000	1.000
244	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(5), CALM1(1), CALM3(1), ELK1(1), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP3K1(3), MAPK14(1), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2)	17423793	97	73	90	18	19	17	35	16	10	0	0.00949	1.000	1.000
245	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(2), LDHA(1), LDHB(1), LDHC(3), MAPK14(1), NCL(3)	4092084	11	11	11	6	2	0	4	3	2	0	0.935	1.000	1.000
246	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMKK1(1), CAMKK2(5), CREB1(1), SYT1(5)	5260732	22	22	22	7	3	4	7	5	3	0	0.605	1.000	1.000
247	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(4), CREB1(1), CREB5(5), MAPK1(4), RAF1(2), SRC(1)	5080555	18	15	15	5	4	2	8	1	3	0	0.563	1.000	1.000
248	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM3(1), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), SP1(1), SP3(1), SYT1(5)	9559825	37	32	37	8	10	7	10	7	3	0	0.0781	1.000	1.000
249	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2)	4776708	15	14	15	6	3	4	4	1	3	0	0.694	1.000	1.000
250	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2)	4776708	15	14	15	6	3	4	4	1	3	0	0.694	1.000	1.000
251	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(3), AKT3(4), CISH(1), IARS(7), IL13RA1(1), IL4(1), IL4R(2), INPP5D(7), JAK1(6), JAK2(2), JAK3(3), NR0B2(1), PI3(1), PIK3CA(64), PPP1R13B(1), RPS6KB1(3), SERPINA4(5), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT6(2), TYK2(2)	16804747	137	105	96	29	9	59	34	30	5	0	0.00116	1.000	1.000
252	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(3), CREBBP(15), EP300(25), IKBKB(5), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(2), MAP3K7(4), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(5), RELA(1), TGFBR1(1), TGFBR2(11), TLR2(1)	13536821	83	71	78	17	8	18	22	15	20	0	0.0613	1.000	1.000
253	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(2), JAK3(3), MAPK1(4), STAT3(3), TYK2(2)	5322868	20	18	16	7	4	3	4	5	4	0	0.637	1.000	1.000
254	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(8), MPI(3), PGM1(3), PYGL(4), PYGM(3), TPI1(2)	6059784	28	26	28	9	7	5	6	5	5	0	0.411	1.000	1.000
255	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), MIOX(2), UGDH(3)	3873966	12	12	12	6	3	1	3	3	2	0	0.824	1.000	1.000
256	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(4), IL1A(1), IL3(1), IL9(1), TGFB1(1), TGFB2(2)	3766855	13	11	13	6	4	1	5	2	1	0	0.767	1.000	1.000
257	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(4), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3), YARS2(3)	3964861	21	19	21	7	2	7	7	4	1	0	0.423	1.000	1.000
258	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), PGM1(3), PGM3(1), TGDS(2)	4651478	21	20	21	7	4	4	7	3	3	0	0.574	1.000	1.000
259	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), CS(2), FH(2), MDH1(1), OGDH(6), SDHA(5), SUCLA2(1)	4286283	19	18	19	7	1	2	10	4	2	0	0.812	1.000	1.000
260	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(3), IL10RB(1), IL1A(1), JAK1(6), STAT1(5), STAT3(3), STAT5A(1)	5548120	22	20	21	8	1	7	6	4	4	0	0.463	1.000	1.000
261	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(1)	5399408	13	13	13	7	0	3	3	4	3	0	0.938	1.000	1.000
262	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(2), GGT1(1), MARS(2), MARS2(4), MAT1A(1), PAPSS1(3), PAPSS2(3), SEPHS1(1)	5637988	18	17	17	5	4	5	5	3	1	0	0.366	1.000	1.000
263	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(2), AP2M1(3), BAD(1), BTK(5), EEA1(8), GSK3B(1), LYN(3), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PLCG1(5), PRKCE(2), PRKCZ(3), RAB5A(2), RAC1(10), RPS6KB1(3), VAV2(1)	11387678	63	52	61	13	6	18	22	10	7	0	0.0348	1.000	1.000
264	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3)	5540691	18	17	18	7	3	2	4	4	5	0	0.718	1.000	1.000
265	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2D2(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2L6(1), UBE3A(4)	4805613	14	14	14	6	2	5	5	0	2	0	0.778	1.000	1.000
266	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), IDS(3), IDUA(3), LCT(8), NAGLU(1)	6522401	26	25	26	8	5	6	7	7	1	0	0.431	1.000	1.000
267	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(3), ARFGAP3(2), ARFGEF2(5), CLTA(1), COPA(7), GBF1(6), GPLD1(3)	7390021	27	25	27	7	5	7	9	3	3	0	0.278	1.000	1.000
268	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(9), BCL2(1), CASP3(1), FAS(1), FASLG(2), IL1A(1), MAPKAPK3(2)	5153734	19	18	19	6	3	5	4	5	2	0	0.507	1.000	1.000
269	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), PER1(5)	3886607	17	17	17	7	3	3	6	4	1	0	0.735	1.000	1.000
270	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4(1), IL4R(2), IRS1(1), JAK1(6), JAK3(3), RPS6KB1(3), SHC1(1), STAT6(2)	6720228	21	20	21	5	4	6	6	3	2	0	0.226	1.000	1.000
271	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CHPT1(1), ENPP2(6), ENPP6(3), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(7), PLD2(1), PPAP2B(1)	10583122	39	36	39	9	4	10	11	8	6	0	0.157	1.000	1.000
272	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2)	6029403	22	19	22	9	3	7	4	4	4	0	0.715	1.000	1.000
273	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CDO1(1), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), SULT1B1(2), SULT1C2(2), SULT4A1(1)	5707741	23	21	23	8	5	3	9	3	3	0	0.595	1.000	1.000
274	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CALM1(1), CALM3(1), CRKL(1), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK14(1), MAPK8(4), PAK1(1), PLCG1(5), PRKCA(2), PTK2B(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5)	12976954	76	57	66	16	17	12	28	12	7	0	0.0639	1.000	1.000
275	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(8), ATF2(1), CALM1(1), CALM3(1), EGFR(14), ELK1(1), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), MEF2A(1), MEF2B(2), MEF2C(7), PAK1(1), PRKCA(2), PTK2(5), PTK2B(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5)	15233076	105	79	95	23	16	19	40	21	9	0	0.0498	1.000	1.000
276	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(14), MAP2K1(4), MAP3K1(3), MAPK14(1), NCOR2(11), RARA(2), RXRA(4), THRA(4), THRB(1)	7874705	50	45	50	12	8	8	18	9	7	0	0.152	1.000	1.000
277	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPNS1(1), CAPNS2(2), CSNK1A1(1), GSK3B(1), MAPT(6)	4192884	14	13	14	5	2	3	7	1	1	0	0.620	1.000	1.000
278	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(4), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), RDH11(1), RDH12(3)	10897024	50	42	50	10	7	9	22	7	5	0	0.0534	1.000	1.000
279	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(15), EP300(25), LPL(2), NCOA1(4), NCOA2(3), RXRA(4)	8423398	53	50	50	13	6	11	16	11	9	0	0.251	1.000	1.000
280	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(1), CREBBP(15), EP300(25), NCOA3(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(2), RXRA(4)	9405441	63	54	60	16	10	17	15	9	12	0	0.197	1.000	1.000
281	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(3), IKBKB(5), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), TNFAIP3(3), TRAF3(3), TRAF6(1)	8277422	23	22	23	9	3	5	5	4	6	0	0.699	1.000	1.000
282	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(3), ELK1(1), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP3K1(3), MAPK1(4), MAPK8IP3(5), PAPPA(9), RAC1(10), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(8), SYK(3), VAV1(2), VAV2(1), VAV3(1)	14612756	79	66	69	17	18	14	24	12	11	0	0.0571	1.000	1.000
283	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
284	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
285	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
286	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(1), ELOVL5(1), ELOVL6(1), FADS2(2), FASN(4), HADHA(3), HSD17B12(1), SCD(1)	6543336	14	13	14	6	1	2	5	2	4	0	0.823	1.000	1.000
287	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR1(3), SEC22B(1), SNAP25(1), STX11(3), STX17(1), STX18(2), STX19(1), STX4(4), STX5(1), STX7(2), STX8(2), TSNARE1(1), USE1(1), VAMP1(1), VAMP5(1)	7593036	26	25	26	7	4	7	8	2	5	0	0.302	1.000	1.000
288	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CREBBP(15), CSNK1A1(1), F2(2), FGF2(1), GSK3B(1), HAND2(2), HRAS(11), LIF(2), MAP2K1(4), MAPK1(4), MAPK14(1), MAPK8(4), MEF2C(7), MYH2(16), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKX2-5(1), NPPA(1), PIK3CA(64), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(2), RPS6KB1(3), SYT1(5)	23134226	194	138	145	38	27	69	48	35	15	0	2.01e-05	1.000	1.000
289	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), CASP1(2), CASP3(1), CASP7(1), CASP8(25), INSR(2), ITCH(5), MAGI1(3), MAGI2(10), RERE(6), WWP1(3), WWP2(2)	10925625	69	60	65	17	6	18	14	12	19	0	0.193	1.000	1.000
290	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKL(4), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7)	11046189	49	46	49	12	7	5	18	12	7	0	0.288	1.000	1.000
291	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT2(3), FBP2(1), G6PC(2), GAA(3), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKM(2), PFKP(4), PGM1(3), PGM3(1)	14813090	72	62	72	15	13	17	21	10	11	0	0.0249	1.000	1.000
292	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	APOA2(1), CPT1B(3), CREBBP(15), EHHADH(2), EP300(25), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), ME1(1), MYC(4), NCOA1(4), NCOR1(12), NCOR2(11), NR0B2(1), NR2F1(2), NRIP1(3), PIK3CA(64), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(9), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(4)	28856356	196	139	147	34	15	74	41	39	27	0	5.16e-06	1.000	1.000
293	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), IDI1(1), LSS(3), PMVK(1)	5046464	14	12	14	9	5	5	2	1	1	0	0.871	1.000	1.000
294	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(4), CASP3(1), CASP8(25), CRADD(1), FADD(1), LMNB1(1), LMNB2(4), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), RB1(9), RIPK1(2), SPTAN1(11), TRAF2(1)	17711681	99	77	96	20	14	15	28	13	29	0	0.0493	1.000	1.000
295	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(15), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(25), FZD1(3), GSK3B(1), LDB1(1), LEF1(2), PITX2(1), TRRAP(10), WNT1(1)	15127941	83	63	80	19	9	23	22	16	12	1	0.0530	1.000	1.000
296	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(3), B4GALT2(3), G6PC(2), G6PC2(3), GAA(3), GALK2(1), GALT(1), GANC(3), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKL(4), PFKM(2), PFKP(4), PGM1(3), PGM3(1), RDH11(1), RDH12(3), UGP2(1)	17569991	88	72	88	18	16	18	29	13	12	0	0.0155	1.000	1.000
297	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(4), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(3)	7279642	23	23	23	8	2	3	11	4	3	0	0.779	1.000	1.000
298	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR7(1), CD28(2), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL4(1), IL4R(2), IL5(1), TGFB1(1), TGFB2(2)	9102244	45	38	44	12	7	9	12	8	9	0	0.168	1.000	1.000
299	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), EPO(2), HIF1A(2), JAK2(2), NFKB1(2), RELA(1), SOD2(1)	5790559	14	14	14	6	2	5	3	3	1	0	0.672	1.000	1.000
300	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(3), CREBBP(15), EP300(25), FADD(1), HDAC3(1), IKBKB(5), NFKB1(2), RELA(1), RIPK1(2), TRAF6(1)	10219755	56	52	53	14	6	15	16	10	9	0	0.169	1.000	1.000
301	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2L1(2), CDC42(1), CDKN1B(2), CDKN2A(61), CREB1(1), CREB5(5), ERBB4(15), F2RL2(1), GAB1(2), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), MET(1), MYC(4), NOLC1(3), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARD3(10), PARD6A(1), PDK1(1), PIK3CA(64), PIK3CD(2), PPP1R13B(1), PREX1(6), PTEN(6), PTK2(5), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SLC2A4(1), SOS1(8), SOS2(9), TSC1(2), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	35249880	295	183	219	51	20	82	63	52	77	1	3.77e-08	1.000	1.000
302	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), OPRK1(2), POLR2A(9), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5865799	21	19	21	9	2	7	9	2	1	0	0.729	1.000	1.000
303	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), ELK1(1), FPR1(3), GNA15(2), GNB1(2), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NCF2(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(1), PIK3C2G(7), PLCB1(12), RAC1(10), RAF1(2), RELA(1), SYT1(5)	17422621	107	84	97	25	27	17	37	17	9	0	0.0427	1.000	1.000
304	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(4), BIRC2(1), BIRC3(1), CASP3(1), CASP8(25), CFLAR(2), FADD(1), MAP2K4(1), MAP3K3(1), MAP3K7(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(2), RIPK1(2), TNFAIP3(3), TRAF2(1)	12455668	55	50	52	13	7	14	11	6	17	0	0.0753	1.000	1.000
305	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(1), ETV5(3), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), JAK2(2), MAP2K6(1), MAPK14(1), MAPK8(4), STAT4(3), TYK2(2)	8497800	36	32	36	10	2	9	14	5	6	0	0.438	1.000	1.000
306	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB5(5), DUSP10(2), EEF2K(4), ELK1(1), IL1R1(2), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K10(4), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), TRAF6(1)	15189407	64	53	61	14	11	14	17	13	9	0	0.0695	1.000	1.000
307	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(4), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), HAL(2)	8653411	45	40	45	12	8	13	10	12	2	0	0.236	1.000	1.000
308	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), CAPNS1(1), CAPNS2(2), ITGA1(3), ITGB1(12), ITGB3(5), PTK2(5), PXN(1), RAC1(10), SPTAN1(11), SRC(1), TLN1(13)	12980577	80	64	77	18	16	13	30	14	7	0	0.0822	1.000	1.000
309	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(25), CFLAR(2), FADD(1), FAF1(1), LMNB1(1), LMNB2(4), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), PTPN13(9), RB1(9), RIPK2(1), SPTAN1(11)	18597609	103	83	100	22	15	18	24	14	32	0	0.0748	1.000	1.000
310	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTAP(3), MTFMT(3), MTR(4), TAT(1)	9453517	38	31	37	10	7	9	14	5	3	0	0.173	1.000	1.000
311	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TAL1(2), TKT(1)	9302962	37	37	37	11	6	4	13	9	5	0	0.440	1.000	1.000
312	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(7), CALM1(1), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(2), EP300(25), NFATC1(7), NFATC2(6), PRKCA(2), SYT1(5)	11135039	61	55	58	17	10	13	13	15	10	0	0.169	1.000	1.000
313	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(12), GNAS(6), GNB1(2), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	6953378	38	33	38	11	11	6	12	7	2	0	0.411	1.000	1.000
314	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX12B(4), ALOX15(1), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP2U1(1), CYP4A11(8), CYP4A22(6), CYP4F2(3), CYP4F3(1), DHRS4(2), EPHX2(4), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	17719710	95	75	95	21	13	22	31	15	14	0	0.0175	1.000	1.000
315	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(2), F12(1), F13B(9), F2(2), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), LPA(8), PLAT(2), PLAU(1), PLG(8), SERPINB2(1), SERPINE1(4), VWF(6)	16082803	82	64	82	19	7	18	28	16	13	0	0.0802	1.000	1.000
316	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), CFL1(2), GNAS(6), GNB1(2), HRAS(11), LIMK1(5), MAP2K1(4), MAPK1(4), NOX1(5), PIK3C2G(7), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2(5), RAF1(2), ROCK2(6)	11447945	77	68	69	19	17	15	29	7	9	0	0.216	1.000	1.000
317	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(5), APC(15), ATF2(1), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(2), BMP7(3), BMPR2(3), CHRD(6), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MEF2C(7), NKX2-5(1), NPPA(1), NPPB(1), RFC1(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TGFBR3(3), WNT1(1)	16615699	89	69	87	21	8	22	26	17	15	1	0.0910	1.000	1.000
318	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), BCR(1), CAPNS1(1), CAPNS2(2), CRKL(1), CSK(1), FYN(3), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK8(4), PPP1R12B(1), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SOS1(8), SRC(1), TLN1(13), VCL(6), ZYX(2)	21480827	119	81	110	26	20	23	47	18	11	0	0.0310	1.000	1.000
319	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(3), AKT3(4), BRAF(4), EIF4B(2), EIF4EBP1(1), HIF1A(2), MAPK1(4), PDPK1(2), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKAA1(3), PRKAA2(2), RICTOR(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), STK11(2), TSC1(2), TSC2(3), ULK1(5), ULK2(2), VEGFC(3)	24188572	169	128	125	32	24	61	34	35	14	1	9.09e-05	1.000	1.000
320	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2)	10440262	66	50	66	19	12	16	19	12	7	0	0.199	1.000	1.000
321	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2)	10440262	66	50	66	19	12	16	19	12	7	0	0.199	1.000	1.000
322	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(2), GPRC5B(2), GPRC5C(2), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM7(8), GRM8(12)	9519867	72	59	72	23	16	15	26	13	2	0	0.123	1.000	1.000
323	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(4), ARRB1(2), ARRB2(1), ATF2(1), ATF4(1), BDNF(2), BRAF(4), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CACNA2D1(12), CACNA2D3(2), CACNA2D4(3), CACNB1(5), CACNB2(4), CACNB3(2), CACNB4(1), CACNG1(1), CACNG2(2), CACNG4(2), CACNG5(3), CACNG6(4), CACNG7(1), CACNG8(4), CASP3(1), CD14(1), CDC25B(3), CDC42(1), CHUK(3), CRK(1), CRKL(1), DUSP10(2), DUSP14(1), DUSP16(2), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(3), DUSP6(3), DUSP7(1), DUSP9(1), ECSIT(1), EGF(6), EGFR(14), ELK1(1), ELK4(3), FAS(1), FASLG(2), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(4), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FLNA(8), FLNB(4), FLNC(7), FOS(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(11), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAPT(6), MAX(1), MEF2C(7), MKNK1(1), MKNK2(1), MOS(5), MYC(4), NF1(10), NFATC2(6), NFATC4(2), NFKB1(2), NFKB2(1), NLK(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(1), PAK1(1), PAK2(5), PDGFRA(6), PDGFRB(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PPM1A(3), PPP5C(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTPN7(2), PTPRR(4), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF2(2), RASA1(14), RASA2(6), RASGRF1(9), RASGRF2(5), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KA6(4), RRAS2(1), SOS1(8), SOS2(9), STK3(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TP53(238), TRAF2(1), TRAF6(1), ZAK(2)	129857442	894	281	785	204	162	159	241	150	175	7	5.10e-09	1.000	1.000
324	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(15), APC2(3), AXIN1(5), AXIN2(5), BTRC(1), CACYBP(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND1(2), CHD8(7), CREBBP(15), CSNK1A1(1), CSNK1E(3), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(2), CUL1(6), CXXC4(1), DAAM1(6), DAAM2(6), DKK1(3), DKK2(3), DVL1(2), DVL2(1), DVL3(4), EP300(25), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LEF1(2), LRP5(3), LRP6(12), MAP3K7(4), MAPK10(3), MAPK8(4), MAPK9(4), MMP7(1), MYC(4), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKD1(5), NKD2(1), NLK(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PORCN(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRICKLE1(4), PRICKLE2(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAC1(10), RAC2(1), RAC3(2), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), SENP2(2), SFRP1(1), SFRP4(8), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(3), SMAD3(2), SMAD4(8), SOX17(1), TBL1X(4), TBL1XR1(3), TBL1Y(2), TCF7(2), TCF7L1(1), TP53(238), VANGL1(1), VANGL2(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1)	73578741	632	275	532	120	109	117	165	99	134	8	6.63e-11	1.000	1.000
325	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), BRAF(4), CAPN2(4), CCND1(2), CDC42(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(6), DOCK1(8), EGF(6), EGFR(14), ELK1(1), ERBB2(8), FARP2(1), FLNA(8), FLNB(4), FLNC(7), FLT1(10), FN1(14), FYN(3), GRLF1(12), GSK3B(1), HGF(8), HRAS(11), IBSP(1), IGF1R(7), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAV(2), ITGB1(12), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KDR(5), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), MAP2K1(4), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MET(1), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(6), PDPK1(2), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP5K1C(2), PPP1R12A(3), PRKCA(2), PRKCG(7), PTEN(6), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF1(2), RELN(37), RHOA(4), ROCK1(11), ROCK2(6), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SPP1(1), SRC(1), THBS1(7), THBS2(7), THBS4(5), TLN1(13), TLN2(7), TNC(8), TNN(15), TNR(7), TNXB(10), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), VEGFC(3), VTN(2), VWF(6), ZYX(2)	169197317	973	266	914	271	125	240	318	168	120	2	0.000573	1.000	1.000
326	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), APC(15), APC2(3), ARHGEF1(5), ARHGEF12(8), ARHGEF4(2), ARHGEF6(3), ARHGEF7(1), ARPC1B(1), ARPC2(2), ARPC4(1), BCAR1(2), BDKRB1(1), BRAF(4), C3orf10(1), CD14(1), CDC42(1), CFL1(2), CHRM2(4), CHRM3(5), CHRM5(1), CRK(1), CRKL(1), CSK(1), CYFIP1(5), CYFIP2(5), DIAPH1(6), DIAPH2(6), DIAPH3(9), DOCK1(8), EGF(6), EGFR(14), F2(2), FGD1(10), FGD3(4), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(4), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FN1(14), GIT1(1), GNA12(1), GNA13(1), GNG12(1), GRLF1(12), GSN(5), HRAS(11), IQGAP1(5), IQGAP2(4), IQGAP3(7), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB1(12), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KRAS(1), LIMK1(5), LIMK2(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MOS(5), MSN(3), MYH10(17), MYH14(3), MYH9(12), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), NCKAP1(5), NCKAP1L(5), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDGFRA(6), PDGFRB(6), PFN4(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PPP1R12A(3), PPP1R12B(1), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RHOA(4), ROCK1(11), ROCK2(6), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(8), SOS2(9), SSH1(3), SSH2(4), SSH3(1), TIAM1(7), TIAM2(9), TMSB4Y(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), WASF1(3), WASF2(2), WASL(1)	125718632	694	253	637	208	110	174	203	127	79	1	0.00823	1.000	1.000
327	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY7(2), ADCY8(13), ADCY9(4), ADORA2A(1), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), AGTR1(8), ATP2A1(2), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), ATP2B4(4), AVPR1A(5), AVPR1B(4), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCKAR(4), CCKBR(3), CD38(2), CHRM2(4), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), EDNRB(3), EGFR(14), ERBB2(8), ERBB3(7), ERBB4(15), GNA15(2), GNAL(2), GNAS(6), GRIN2A(14), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), GRPR(1), HRH1(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), LHCGR(2), LTB4R2(1), MYLK(4), MYLK2(2), NOS1(3), NOS3(4), NTSR1(2), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRA(6), PDGFRB(6), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(2), RYR1(16), RYR2(44), RYR3(23), SLC25A6(1), SLC8A1(8), SLC8A2(4), SLC8A3(10), SPHK2(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), TRHR(4), TRPC1(4)	122233916	663	237	661	236	134	143	214	112	59	1	0.0935	1.000	1.000
328	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR1(8), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKAR(4), CCKBR(3), CGA(1), CHRM2(4), CHRM3(5), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHB(1), FSHR(5), GABBR1(2), GABBR2(4), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GABRB1(5), GABRB2(7), GABRB3(11), GABRE(2), GABRG1(4), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(2), GALR2(3), GH1(1), GH2(2), GHR(4), GHRHR(2), GHSR(3), GIPR(1), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(3), GLRA3(2), GLRB(3), GPR156(2), GPR50(1), GPR63(4), GRIA1(9), GRIA2(10), GRIA3(5), GRIA4(7), GRID1(11), GRID2(13), GRIK1(4), GRIK2(4), GRIK3(5), GRIK4(4), GRIK5(6), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRIN3A(10), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM6(3), GRM7(8), GRM8(12), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HRH4(3), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), LEP(1), LEPR(11), LHB(1), LHCGR(2), LTB4R(2), LTB4R2(1), MAS1(3), MC2R(7), MC3R(3), MC4R(3), MC5R(5), MCHR1(1), MCHR2(4), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR2(8), NPY1R(5), NPY2R(3), NPY5R(7), NR3C1(5), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PARD3(10), PPYR1(1), PRL(3), PRLHR(2), PRLR(4), PRSS1(8), PRSS3(1), PTGDR(1), PTGER2(4), PTGER3(2), PTGER4(2), PTGFR(2), PTH2R(6), RXFP1(4), RXFP2(4), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TAAR1(2), TAAR2(2), TAAR6(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), THRA(4), THRB(1), TRHR(4), TRPV1(5), TSHR(2), UTS2R(1), VIPR2(3)	100896362	705	232	702	244	113	130	262	131	69	0	0.0565	1.000	1.000
329	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(4), ABLIM2(3), ABLIM3(2), ARHGEF12(8), CDC42(1), CFL1(2), CXCL12(1), CXCR4(1), DCC(19), DPYSL2(2), DPYSL5(2), EFNA5(2), EFNB1(2), EFNB2(1), EPHA1(6), EPHA2(16), EPHA3(12), EPHA4(9), EPHA5(12), EPHA6(10), EPHA7(11), EPHA8(3), EPHB1(9), EPHB2(2), EPHB3(5), EPHB4(3), EPHB6(4), FES(4), FYN(3), GNAI1(1), GNAI3(1), GSK3B(1), HRAS(11), ITGB1(12), KRAS(1), L1CAM(3), LIMK1(5), LIMK2(3), LRRC4C(18), MAPK1(4), MET(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTNG1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLXNA1(16), PLXNA2(6), PLXNA3(9), PLXNB1(3), PLXNB2(14), PLXNB3(5), PLXNC1(7), PTK2(5), RAC1(10), RAC2(1), RAC3(2), RASA1(14), RGS3(2), RHOA(4), RHOD(1), ROBO1(7), ROBO2(11), ROBO3(2), ROCK1(11), ROCK2(6), SEMA3A(10), SEMA3B(1), SEMA3C(4), SEMA3D(1), SEMA3E(8), SEMA3F(3), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(1), SEMA4F(3), SEMA4G(2), SEMA5A(20), SEMA5B(8), SEMA6A(2), SEMA6B(2), SEMA6C(1), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(15), SLIT3(3), SRGAP1(6), SRGAP2(1), SRGAP3(2), UNC5A(3), UNC5B(4), UNC5C(12), UNC5D(14)	89670176	556	227	536	156	86	114	175	104	76	1	0.00394	1.000	1.000
330	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(2), ACTG1(2), CHAD(3), COL11A1(38), COL11A2(6), COL17A1(7), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DES(1), DSC1(1), DSC2(1), DSG1(4), DSG2(2), DSG3(2), DSG4(1), FN1(14), GJA1(1), GJA10(3), GJA3(1), GJA5(2), GJA8(6), GJA9(2), GJB3(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(1), ITGA6(3), ITGB4(3), KRT1(2), KRT10(4), KRT12(3), KRT13(2), KRT14(6), KRT15(1), KRT16(1), KRT18(1), KRT2(3), KRT23(1), KRT24(5), KRT25(5), KRT27(2), KRT28(2), KRT31(3), KRT32(1), KRT33A(1), KRT33B(2), KRT34(3), KRT35(1), KRT36(4), KRT38(5), KRT39(4), KRT4(6), KRT40(2), KRT5(8), KRT6A(2), KRT6B(1), KRT6C(3), KRT7(2), KRT71(1), KRT72(1), KRT73(3), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(6), KRT79(2), KRT83(3), KRT85(2), KRT86(2), KRT9(1), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), LMNB1(1), LMNB2(4), NES(7), RELN(37), SPP1(1), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VIM(2), VTN(2), VWF(6)	113623912	589	216	587	176	87	118	211	91	81	1	0.0504	1.000	1.000
331	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD44(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DAG1(1), FN1(14), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(3), GP6(1), GP9(1), HMMR(1), HSPG2(11), IBSP(1), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAV(2), ITGB1(12), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), RELN(37), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VTN(2), VWF(6)	102323635	545	207	542	163	80	116	182	95	72	0	0.0696	1.000	1.000
332	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ANXA6(4), ARRB1(2), ARRB2(1), ATP1A4(4), ATP1B3(3), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1S(11), CACNB1(5), CACNB3(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CASQ1(1), CASQ2(2), CHRM2(4), CHRM3(5), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GNAI3(1), GNAO1(2), GNAZ(2), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNB1(3), KCNJ3(4), KCNJ5(3), MIB1(5), NME7(2), PEA15(1), PKIG(1), PLCB3(5), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SLC8A3(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1)	85222888	484	204	481	169	97	109	141	83	53	1	0.159	1.000	1.000
333	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), AMOTL1(2), ASH1L(11), CASK(1), CDC42(1), CDK4(4), CGN(3), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTTN(4), EPB41L1(5), EPB41L2(7), EPB41L3(16), EXOC3(1), EXOC4(10), F11R(1), GNAI1(1), GNAI3(1), HCLS1(2), HRAS(11), IGSF5(3), INADL(7), KRAS(1), LLGL2(3), MAGI1(3), MAGI2(10), MAGI3(6), MLLT4(5), MPDZ(8), MPP5(5), MYH1(11), MYH10(17), MYH11(11), MYH13(16), MYH14(3), MYH15(9), MYH2(16), MYH3(8), MYH4(13), MYH6(10), MYH7(9), MYH7B(5), MYH8(18), MYH9(12), MYL7(1), MYL9(2), MYLPF(2), NRAS(1), PARD3(10), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PPP2R3A(5), PPP2R3B(3), PPP2R4(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PTEN(6), RAB13(1), RHOA(4), RRAS2(1), SPTAN1(11), SRC(1), SYMPK(4), TJAP1(1), TJP1(9), TJP2(4), TJP3(5), VAPA(1), YES1(1), ZAK(2)	88285284	496	203	487	154	79	110	172	76	57	2	0.0971	1.000	1.000
334	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(2), AKT2(3), AKT3(4), BCL2L1(2), CBL(2), CBLB(2), CCND1(2), CISH(1), CREBBP(15), CSF2RA(1), CSF2RB(5), CSF3R(2), EP300(25), EPO(2), GH1(1), GH2(2), GHR(4), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL13RA2(1), IL19(1), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), IRF9(2), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), LIF(2), LIFR(9), MPL(2), MYC(4), OSMR(3), PIAS2(1), PIAS3(3), PIAS4(2), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIM1(2), PRL(3), PRLR(4), PTPN11(1), PTPN6(1), SOCS4(1), SOCS5(5), SOCS7(2), SOS1(8), SOS2(9), SPRED1(2), SPRED2(1), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), STAM(2), STAM2(2), STAT1(5), STAT2(3), STAT3(3), STAT4(3), STAT5A(1), STAT5B(4), STAT6(2), TPO(10), TYK2(2)	66248791	389	199	342	101	39	119	104	85	41	1	0.00135	1.000	1.000
335	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(11), ACACB(12), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), CALM1(1), CALM3(1), CBL(2), CBLB(2), CRK(1), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(1), FASN(4), FBP2(1), FLOT1(1), FLOT2(3), FOXO1(3), G6PC(2), G6PC2(3), GCK(2), GSK3B(1), GYS1(5), GYS2(5), HRAS(11), IKBKB(5), INPP5D(7), INSR(2), IRS1(1), IRS2(2), IRS4(10), KRAS(1), LIPE(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(1), NRAS(1), PCK2(3), PDE3A(13), PDE3B(1), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PKLR(1), PKM2(3), PPARGC1A(3), PPP1R3A(7), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(2), PRKCZ(3), PRKX(1), PTPN1(2), PTPRF(10), PYGB(3), PYGL(4), PYGM(3), RAF1(2), RAPGEF1(2), RHOQ(1), RPS6KB1(3), RPS6KB2(1), SH2B2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SLC2A4(1), SOCS4(1), SORBS1(2), SOS1(8), SOS2(9), SREBF1(3), TRIP10(5), TSC1(2), TSC2(3)	72926308	411	199	362	104	76	106	118	76	34	1	0.000235	1.000	1.000
336	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ACTN1(2), ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(2), BRAF(4), CDC42(1), CDKN2A(61), CRK(1), CSE1L(2), DOCK1(8), EPHB2(2), FYN(3), GRB7(2), GRLF1(12), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGB3BP(1), MAP2K4(1), MAP3K11(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MYLK(4), MYLK2(2), P4HB(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CA(64), PIK3CB(5), PKLR(1), PLCG1(5), PLCG2(4), PTEN(6), PTK2(5), RAF1(2), RHO(3), ROCK1(11), ROCK2(6), SHC1(1), SOS1(8), SOS2(9), SRC(1), TLN1(13), TLN2(7), VASP(1), ZYX(2)	55717740	375	197	296	77	37	89	102	62	84	1	2.94e-06	1.000	1.000
337	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(2), ACTA2(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ARRB1(2), ARRB2(1), ATF1(2), ATF2(1), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(3), CACNB3(2), CALCA(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(4), ETS2(5), FOS(1), GABPA(2), GBA2(3), GJA1(1), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), GSTO1(2), GUCY1A3(4), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL1B(1), ITPR1(9), ITPR2(11), ITPR3(5), MIB1(5), MYLK2(2), NFKB1(2), NOS1(3), NOS3(4), OXTR(2), PDE4B(4), PDE4D(5), PKIG(1), PLCB3(5), PLCD1(2), PLCG1(5), PLCG2(4), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SP1(1), TNXB(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1)	78750008	412	191	411	131	76	102	116	71	46	1	0.0611	1.000	1.000
338	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADK(1), ADSL(4), ADSS(2), ADSSL1(2), AK1(1), AK2(1), AK3L1(1), AK5(5), AK7(2), ALLC(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), GART(3), GDA(4), GMPR2(1), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NME7(2), NPR1(1), NPR2(5), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(3), PAPSS2(3), PDE10A(12), PDE11A(2), PDE1A(3), PDE1C(9), PDE2A(1), PDE3B(1), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE7A(3), PDE8B(7), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), PNPT1(4), POLA1(2), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRIM2(9), PRPS1(3), PRPS1L1(4), PRPS2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(3)	74382344	358	189	356	109	61	73	124	56	44	0	0.143	1.000	1.000
339	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI3(1), GRLF1(12), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB1(12), ITGB2(2), ITK(1), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(5), MMP2(2), MSN(3), MYL7(1), MYL9(2), MYLPF(2), NCF2(4), NCF4(1), NOX1(5), NOX3(4), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAC1(10), RAC2(1), RAP1B(2), RAPGEF3(5), RASSF5(1), RHOA(4), ROCK1(11), ROCK2(6), SIPA1(1), THY1(1), TXK(3), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(3), VCL(6)	56623490	347	188	299	105	39	93	96	74	43	2	0.0735	1.000	1.000
340	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRB1(1), DRD1(1), DRD2(2), EGF(6), EGFR(14), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAS(6), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HRAS(11), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K5(2), MAPK1(4), MAPK7(1), NPR1(1), NPR2(5), NRAS(1), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(6), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), PRKX(1), RAF1(2), SOS1(8), SOS2(9), SRC(1), TJP1(9), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1)	60083924	350	186	340	101	64	74	119	58	35	0	0.0126	1.000	1.000
341	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(7), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), BTC(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(2), CBLB(2), CDKN1B(2), CRK(1), CRKL(1), EGF(6), EGFR(14), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(7), ERBB4(15), GAB1(2), GSK3B(1), HRAS(11), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MYC(4), NCK1(4), NCK2(3), NRAS(1), NRG1(1), NRG2(4), NRG3(8), NRG4(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), RAF1(2), RPS6KB1(3), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SRC(1), STAT5A(1), STAT5B(4)	46883115	331	185	281	82	38	99	101	65	27	1	0.00133	1.000	1.000
342	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(2), CADM3(1), CD2(1), CD22(1), CD226(3), CD28(2), CD34(4), CD40(4), CD40LG(3), CD6(1), CD80(5), CD86(1), CD8A(2), CD8B(1), CDH1(4), CDH15(2), CDH2(5), CDH3(6), CDH4(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CNTN1(7), CNTN2(4), CNTNAP1(6), CNTNAP2(21), CTLA4(1), ESAM(1), F11R(1), GLG1(3), HLA-A(9), HLA-B(10), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(6), ITGA6(3), ITGA8(12), ITGA9(1), ITGAL(3), ITGAM(3), ITGAV(2), ITGB1(12), ITGB2(2), ITGB7(1), ITGB8(3), L1CAM(3), MAG(1), MPZL1(2), NCAM1(1), NCAM2(7), NEGR1(2), NEO1(1), NFASC(3), NLGN1(12), NLGN2(3), NRCAM(9), NRXN1(20), NRXN2(9), NRXN3(14), PDCD1(1), PTPRC(13), PTPRF(10), PTPRM(14), PVR(2), PVRL2(3), PVRL3(4), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SELE(4), SELL(2), SELP(11), SIGLEC1(10), SPN(2), VCAM1(3), VCAN(15)	67191827	386	181	384	141	67	65	122	66	65	1	0.466	1.000	1.000
343	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(2), BRAF(4), CASP3(1), CD247(1), CD48(1), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(3), FYN(3), GZMB(1), HLA-A(9), HLA-B(10), HLA-C(3), HRAS(11), ICAM1(2), ICAM2(2), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), ITGAL(3), ITGB2(2), KIR2DL1(3), KIR2DL3(1), KIR3DL1(7), KLRC2(1), KLRC3(2), KRAS(1), LAT(3), LCK(5), LCP2(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MICB(3), NCR1(5), NCR2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRF1(3), PRKCA(2), PRKCG(7), PTK2B(2), PTPN11(1), PTPN6(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SH2D1A(4), SH2D1B(2), SH3BP2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SYK(3), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP2(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(2)	51680949	343	181	289	89	53	88	86	67	47	2	0.00178	1.000	1.000
344	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(1), ACTN2(6), ACTN3(6), ACTN4(3), DES(1), DMD(33), FAM48A(2), MYBPC1(11), MYBPC2(3), MYBPC3(3), MYH3(8), MYH6(10), MYH7(9), MYH8(18), MYL1(1), MYL9(2), MYOM1(11), NEB(26), TNNI2(1), TNNI3(1), TNNT1(2), TNNT3(1), TPM1(1), TTN(248), VIM(2)	62136330	412	181	410	110	44	98	161	62	44	3	0.200	1.000	1.000
345	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM3(1), CDIPT(1), CDS1(1), CDS2(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPP5D(7), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), OCRL(4), PI4KA(5), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3C3(2), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(7), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(4)	56607342	333	179	291	83	40	96	86	72	38	1	0.000221	1.000	1.000
346	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(5), ACVR1B(4), ACVRL1(3), AKT1(2), AURKB(3), BMPR2(3), BUB1(2), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(1), CDS2(3), CLK1(3), CLK2(5), COL4A3BP(4), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MAP3K10(4), MOS(5), NEK1(3), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CA(64), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4), PLK3(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKG1(3), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KB1(3), STK11(2), TGFBR1(1), VRK1(1)	51365862	332	179	289	78	56	88	84	68	35	1	0.000159	1.000	1.000
347	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR1(8), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCBP2(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CCRL1(1), CCRL2(1), CHML(3), CHRM2(4), CHRM3(5), CHRM5(1), CMKLR1(4), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR17(1), GPR174(2), GPR27(2), GPR3(2), GPR37(5), GPR37L1(2), GPR50(1), GPR6(4), GPR63(4), GPR77(2), GRPR(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), LHCGR(2), LTB4R(2), MAS1(3), MC3R(3), MC4R(3), MC5R(5), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPY1R(5), NPY2R(3), NPY5R(7), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(3), OR1Q1(2), OR2H1(3), OR5V1(4), OR7A5(3), OR8B8(1), OXTR(2), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PPYR1(1), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), RGR(3), RHO(3), RRH(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(4)	55307010	332	178	331	134	62	61	128	59	22	0	0.357	1.000	1.000
348	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(5), ACVR1B(4), ACVR2A(2), AMHR2(1), BMP2(3), BMP7(3), BMPR1B(1), BMPR2(3), CCL1(3), CCL15(1), CCL2(2), CCL20(1), CCL23(2), CCL25(2), CCL28(1), CCL3(1), CCL7(1), CCL8(2), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CD27(1), CD40(4), CD40LG(3), CSF1(1), CSF2RA(1), CSF2RB(5), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL10(2), CXCL12(1), CXCL13(1), CXCL2(1), CXCL3(1), CXCL9(1), CXCR3(1), CXCR4(1), EDA(4), EDAR(1), EGF(6), EGFR(14), EPO(2), FAS(1), FASLG(2), FLT1(10), FLT3(4), FLT3LG(1), FLT4(6), GDF5(3), GH1(1), GH2(2), GHR(4), HGF(8), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL17A(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL1RAP(4), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL25(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), INHBA(1), INHBB(2), INHBC(3), INHBE(1), KDR(5), KIT(5), LEP(1), LEPR(11), LIF(2), LIFR(9), LTA(1), LTBR(2), MET(1), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(6), PDGFRB(6), PF4V1(1), PLEKHO2(2), PPBP(2), PRL(3), PRLR(4), RELT(3), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(2), TNFRSF13C(2), TNFRSF19(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(2), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF13B(1), TNFSF14(2), TNFSF18(1), TNFSF4(2), TNFSF8(2), TPO(10), VEGFC(3), XCL1(1), XCL2(1), XCR1(2)	80688818	391	178	385	129	57	76	136	74	48	0	0.288	1.000	1.000
349	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(4), CREBBP(15), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), EGFR(14), EP300(25), ERBB2(8), FARP2(1), FER(2), FGFR1(1), FYN(3), IGF1R(7), INSR(2), IQGAP1(5), LEF1(2), LMO7(6), MAP3K7(4), MAPK1(4), MET(1), MLLT4(5), NLK(1), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(11), PTPRF(10), PTPRJ(6), PTPRM(14), PVRL2(3), PVRL3(4), PVRL4(2), RAC1(10), RAC2(1), RAC3(2), RHOA(4), SMAD2(3), SMAD3(2), SMAD4(8), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7(2), TCF7L1(1), TGFBR1(1), TGFBR2(11), TJP1(9), VCL(6), WASF1(3), WASF2(2), WASF3(2), WASL(1), YES1(1)	54508747	323	178	309	86	45	74	92	62	49	1	0.0190	1.000	1.000
350	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(2), CBLB(2), CD247(1), CD28(2), CD3D(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CDK4(4), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(1), HRAS(11), ICOS(1), IFNG(1), IKBKB(5), IL4(1), IL5(1), ITK(1), KRAS(1), LAT(3), LCK(5), LCP2(1), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDCD1(1), PDK1(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PRKCQ(5), PTPN6(1), PTPRC(13), RASGRP1(5), RHOA(4), SOS1(8), SOS2(9), TEC(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(2)	46325167	292	177	243	70	37	89	74	58	33	1	0.000922	1.000	1.000
351	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(3), AKT3(4), CASP8(25), CCL3(1), CD14(1), CD40(4), CD80(5), CD86(1), CHUK(3), CXCL10(2), CXCL9(1), FADD(1), FOS(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(2), IL12A(1), IL12B(4), IL1B(1), IRAK1(2), IRAK4(3), IRF3(1), IRF5(1), IRF7(2), LBP(7), LY96(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K7(4), MAP3K8(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), RAC1(10), RELA(1), RIPK1(2), SPP1(1), STAT1(5), TBK1(1), TICAM1(4), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR6(3), TLR7(4), TLR8(2), TLR9(2), TRAF3(3), TRAF6(1)	40910053	285	176	236	56	35	85	70	59	35	1	1.28e-06	1.000	1.000
352	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ATF4(1), CACNA1C(11), CACNA1D(15), CACNA1F(6), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDC42(1), CGA(1), EGFR(14), ELK1(1), FSHB(1), GNAS(6), HRAS(11), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LHB(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K3(1), MAP3K4(5), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK9(4), MMP14(2), MMP2(2), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLD1(7), PLD2(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(1), PTK2B(2), RAF1(2), SOS1(8), SOS2(9), SRC(1)	57679661	314	174	306	86	56	69	99	56	34	0	0.00668	1.000	1.000
353	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(11), ASH2L(2), C17orf79(1), CARM1(3), CTCFL(2), DOT1L(3), EED(2), EHMT1(6), EHMT2(6), EZH1(3), EZH2(1), FBXO11(6), HCFC1(6), JMJD4(2), JMJD6(2), KDM6A(8), MEN1(2), MLL(15), MLL2(57), MLL3(25), MLL4(7), MLL5(7), NSD1(36), OGT(3), PAXIP1(2), PRDM2(4), PRDM7(1), PRDM9(22), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SATB1(5), SETD1A(6), SETD2(8), SETD7(2), SETD8(1), SETDB1(6), SETMAR(1), SMYD3(1), STK38(2), SUV39H1(2), SUV420H1(4), SUV420H2(2), SUZ12(1), WHSC1(11), WHSC1L1(1)	53952329	306	173	301	61	24	53	86	36	102	5	0.00590	1.000	1.000
354	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), AKAP1(5), AKAP10(3), AKAP11(6), AKAP12(10), AKAP2(1), AKAP3(5), AKAP4(5), AKAP5(2), AKAP6(14), AKAP7(1), AKAP8(2), AKAP9(21), ARHGEF1(5), CALM1(1), CALM3(1), CHMP1B(2), GNA12(1), GNA13(1), GNA15(2), GNAI3(1), GNAL(2), GNAO1(2), GNAZ(2), GNB1(2), GNB2(3), GNB3(3), GNB5(1), GNG12(1), HRAS(11), ITPR1(9), KCNJ3(4), KRAS(1), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE7A(3), PDE8B(7), PLCB3(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKD3(9), RHOA(4), SLC9A1(4), USP5(4)	53167995	313	172	304	80	64	66	90	51	42	0	0.00654	1.000	1.000
355	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREB3L4(1), CREBBP(15), CTNNB1(2), DCT(1), DVL1(2), DVL2(1), DVL3(4), EDNRB(3), EP300(25), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GSK3B(1), HRAS(11), KIT(5), KRAS(1), LEF1(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MITF(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), POMC(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), TCF7(2), TCF7L1(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1)	49557003	282	168	271	79	60	52	90	50	29	1	0.00932	1.000	1.000
356	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADK(1), ADSL(4), ADSS(2), AK1(1), AK2(1), AK5(5), ALLC(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), GART(3), GDA(4), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NPR1(1), NPR2(5), NUDT2(1), PAPSS1(3), PAPSS2(3), PDE1A(3), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE6C(2), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RRM1(1), RRM2(1)	58405584	281	163	279	82	48	55	102	42	34	0	0.0730	1.000	1.000
357	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(12), ADCY8(13), ATF4(1), BRAF(4), CACNA1C(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREBBP(15), EP300(25), GRIA1(9), GRIA2(10), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), HRAS(11), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP1R12A(3), PPP1R1A(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), RAP1B(2), RAPGEF3(5), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4)	45145076	291	162	280	85	48	68	90	55	30	0	0.0246	1.000	1.000
358	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(2), AMY2B(6), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHX58(2), ENPP1(5), ENPP3(5), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), G6PC(2), G6PC2(3), GAA(3), GANC(3), GBA(2), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), IFIH1(5), MGAM(18), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SI(40), SKIV2L2(3), SMARCA2(8), SMARCA5(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), UXS1(1)	56297057	286	159	285	90	32	56	108	59	31	0	0.530	1.000	1.000
359	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(3), AKT3(4), BTK(5), FCER1A(2), FYN(3), GAB2(2), HRAS(11), IL13(1), IL3(1), IL4(1), IL5(1), INPP5D(7), KRAS(1), LAT(3), LCP2(1), LYN(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MS4A2(2), NRAS(1), PDK1(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCD(4), PRKCE(2), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SOS1(8), SOS2(9), SYK(3), VAV1(2), VAV2(1), VAV3(1)	32854167	251	156	200	54	31	78	68	52	21	1	0.000165	1.000	1.000
360	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(5), ACVR1B(4), ACVR1C(3), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BMPR1B(1), BMPR2(3), CHRD(6), CREBBP(15), CUL1(6), DCN(2), E2F4(1), E2F5(4), EP300(25), FST(1), GDF5(3), GDF6(1), ID1(1), IFNG(1), INHBA(1), INHBB(2), INHBC(3), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(15), MAPK1(4), MYC(4), PITX2(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), RBL1(8), RBL2(3), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(3), SMAD3(2), SMAD4(8), SMAD5(2), SMAD9(2), SMURF1(2), SMURF2(4), SP1(1), TFDP1(3), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), THBS1(7), THBS2(7), THBS4(5), ZFYVE16(3), ZFYVE9(5)	45099846	256	154	245	46	29	54	74	47	52	0	1.75e-05	1.000	1.000
361	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(4), C7orf16(1), CACNA1A(7), GNA12(1), GNA13(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GNAZ(2), GRIA1(9), GRIA2(10), GRIA3(5), GRID2(13), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HRAS(11), IGF1R(7), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NOS1(3), NOS3(4), NPR1(1), NPR2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), RAF1(2), RYR1(16)	49985031	268	149	257	82	47	55	93	49	24	0	0.140	1.000	1.000
362	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(4), BCAR1(2), CAPN10(3), CAPN11(1), CAPN2(4), CAPN3(3), CAPN5(1), CAPN6(2), CAPN7(1), CAPN9(3), CAPNS1(1), CDC42(1), CRK(1), CSK(1), DOCK1(8), FYN(3), GIT2(1), ILK(4), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB1(12), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAPK10(3), MAPK12(1), MAPK4(6), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(2), RHO(3), ROCK1(11), ROCK2(6), SDCCAG8(3), SHC1(1), SHC3(3), SORBS1(2), SOS1(8), SRC(1), TLN1(13), TNS1(5), VASP(1), VAV2(1), VAV3(1), VCL(6), ZYX(2)	61028069	277	149	273	86	40	64	93	42	38	0	0.130	1.000	1.000
363	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(4), EGFR(14), ERBB2(8), ERBB4(15), ETS1(2), ETS2(5), ETV6(4), ETV7(1), FMN2(21), KRAS(1), MAP2K1(4), MAPK1(4), NOTCH1(61), NOTCH2(13), NOTCH3(14), NOTCH4(5), PIWIL1(8), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(2), SOS1(8), SOS2(9), SPIRE1(4)	23875620	220	148	214	45	36	41	64	30	49	0	0.00589	1.000	1.000
364	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(3), AKT3(4), BAD(1), CDC42(1), HRAS(11), KDR(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK3(2), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NOS3(4), NRAS(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTGS2(2), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SHC2(3), SPHK2(1), SRC(1)	32851505	231	147	180	57	40	73	56	46	15	1	0.000491	1.000	1.000
365	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(3), AKT3(4), BCL10(1), BLNK(3), BTK(5), CARD11(4), CD19(2), CD22(1), CD72(1), CHUK(3), CR2(5), FCGR2B(1), FOS(1), GSK3B(1), HRAS(11), IFITM1(3), IKBKB(5), INPP5D(7), KRAS(1), LILRB3(5), LYN(3), MALT1(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG2(4), PTPN6(1), RAC1(10), RAC2(1), RAC3(2), RASGRP3(3), SYK(3), VAV1(2), VAV2(1), VAV3(1)	34002593	231	147	182	57	34	78	51	48	19	1	0.000752	1.000	1.000
366	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPPL1(4), IPMK(2), ISYNA1(2), ITPK1(2), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PI4KA(5), PIK3C3(2), PIK3CA(64), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(4)	33834954	219	145	177	56	29	66	58	47	18	1	0.00153	1.000	1.000
367	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(7), CALM1(1), CALM3(1), CAMK2B(2), CD69(1), CEBPB(1), CNR1(3), CREBBP(15), CSNK2A1(6), CSNK2B(2), CTLA4(1), EGR2(1), EP300(25), FCER1A(2), FCGR3A(4), FOS(1), GATA3(6), GRLF1(12), GSK3B(1), HRAS(11), ICOS(1), IFNG(1), IL13(1), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), KPNA5(1), MAPK14(1), MAPK8(4), MAPK9(4), MEF2A(1), MEF2B(2), MYF5(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(8), OPRD1(2), PAK1(1), PIN1(1), PTPRC(13), RELA(1), RPL13A(1), SFN(5), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(2), VAV2(1), VAV3(1), XPO5(1)	41543321	212	141	204	66	29	46	63	43	31	0	0.196	1.000	1.000
368	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(4), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(2), DLL1(4), DLL3(1), DLL4(2), DTX1(5), DTX2(1), DTX3(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(1), DVL3(4), EP300(25), JAG1(6), JAG2(4), LFNG(2), MAML1(1), MAML2(2), MAML3(1), NCOR2(11), NCSTN(1), NOTCH1(61), NOTCH2(13), NOTCH3(14), NOTCH4(5), NUMB(2), PTCRA(2), RBPJ(2), RBPJL(2), RFNG(2), SNW1(2)	31654235	208	139	203	54	37	42	47	28	54	0	0.0187	1.000	1.000
369	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(5), ARHGEF11(3), BTK(5), CDC42(1), CFL1(2), GDI1(2), GDI2(2), INPPL1(4), ITPR1(9), ITPR2(11), ITPR3(5), LIMK1(5), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDK1(1), PIK3CA(64), PIK3CD(2), PIK3CG(8), PIK3R1(6), PITX2(1), PPP1R13B(1), PTEN(6), RACGAP1(3), RHO(3), ROCK1(11), ROCK2(6), WASF1(3), WASL(1)	31886975	208	138	166	55	19	80	45	43	20	1	0.00448	1.000	1.000
370	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), BCR(1), BLNK(3), BTK(5), CD19(2), CD22(1), CR2(5), CSK(1), DAG1(1), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(7), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), MAP4K1(2), MAPK1(4), NFATC1(7), NFATC2(6), NR0B2(1), PDK1(1), PIK3CA(64), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), PTPRC(13), RAF1(2), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2)	33672807	206	133	162	57	22	75	40	47	22	0	0.00684	1.000	1.000
371	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(4), ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG6(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(3), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), CHPF(4), CHST1(3), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHST2(2), CHST4(3), CHST6(6), CHSY1(2), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(3), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GANAB(1), GCNT1(1), GCNT4(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST2(2), NDST3(4), NDST4(7), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(4), STT3B(2), UST(1), WBSCR17(8), XYLT1(7), XYLT2(3)	50282171	216	132	216	92	45	32	78	33	28	0	0.934	1.000	1.000
372	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(12), ABCA12(12), ABCA13(24), ABCA2(8), ABCA3(4), ABCA4(9), ABCA5(3), ABCA6(7), ABCA7(4), ABCA8(5), ABCA9(7), ABCB1(11), ABCB11(6), ABCB4(9), ABCB5(5), ABCB6(5), ABCB7(4), ABCB8(3), ABCC10(5), ABCC11(4), ABCC12(5), ABCC2(4), ABCC3(4), ABCC5(4), ABCC6(2), ABCC8(11), ABCC9(15), ABCD1(2), ABCD2(6), ABCD3(3), ABCD4(3), ABCG1(3), ABCG2(2), ABCG4(4), ABCG8(8), CFTR(7), TAP1(3), TAP2(5)	53812685	244	132	243	79	32	59	79	39	35	0	0.115	1.000	1.000
373	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(4), CHUK(3), CREB1(1), ELK1(1), FOS(1), HRAS(11), IKBKB(5), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP3K9(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAP4K5(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK4(6), MAPK6(3), MAPK7(1), MAPK8(4), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MKNK2(1), MYC(4), NFKB1(2), PAK1(1), PAK2(5), RAC1(10), RAF1(2), RELA(1), RIPK1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KB1(3), RPS6KB2(1), SHC1(1), SP1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1)	43410159	206	130	195	56	33	41	74	30	28	0	0.109	1.000	1.000
374	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(15), AR(4), ASAH1(1), BRAF(4), CCL15(1), DAG1(1), EGFR(14), GNA15(2), GNAI1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), MAPK10(3), MAPK14(1), PHKA2(9), PIK3CA(64), PIK3CD(2), PIK3R1(6), PITX2(1), PTX3(2), RAF1(2), SRC(1)	24169058	179	128	134	38	21	63	41	38	16	0	0.000197	1.000	1.000
375	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(2), CLK2(5), CLK3(3), COL2A1(4), CPSF1(3), CPSF2(3), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDX1(3), DDX20(3), DHX15(1), DHX16(4), DHX38(1), DHX8(3), DHX9(5), DICER1(7), DNAJC8(2), FUS(2), GIPC1(1), LOC440563(2), LSM2(1), METTL3(2), NCBP1(4), NCBP2(3), NONO(2), NUDT21(2), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(9), PRPF4(1), PRPF4B(4), PRPF8(6), PTBP2(1), RBM17(1), RBM5(6), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(3), SF3B2(1), SF3B5(1), SF4(1), SFRS12(2), SFRS14(2), SFRS16(5), SFRS2(2), SFRS4(3), SFRS5(3), SFRS6(4), SFRS7(3), SFRS8(5), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPN(5), SNURF(1), SPOP(4), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(4), XRN2(5)	48212981	191	126	190	64	24	49	58	33	27	0	0.682	1.000	1.000
376	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), C1QC(1), C1R(3), C1S(3), C3(7), C3AR1(2), C4BPA(1), C4BPB(2), C5(5), C5AR1(1), C6(12), C7(5), C8A(6), C8B(4), C8G(1), C9(5), CD46(1), CFB(1), CFH(9), CFI(5), CPB2(3), CR1(8), CR2(5), F10(3), F11(2), F12(1), F13B(9), F2(2), F3(1), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), KNG1(3), MASP1(4), MASP2(4), MBL2(2), PLAT(2), PLAU(1), PLG(8), PROS1(5), SERPINA1(4), SERPINA5(4), SERPINC1(3), SERPIND1(4), SERPINE1(4), SERPING1(3), THBD(2), VWF(6)	41287979	211	122	211	82	16	53	71	35	35	1	0.853	1.000	1.000
377	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCR(1), BLNK(3), BTK(5), CD19(2), CSK(1), DAG1(1), EPHB2(2), ITPKA(1), ITPKB(5), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PI3(1), PIK3CA(64), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(5), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2)	24096068	163	122	119	38	19	62	33	33	16	0	0.00151	1.000	1.000
378	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(12), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ADIPOR1(2), ADIPOR2(3), AKT1(2), AKT2(3), AKT3(4), CAMKK1(1), CAMKK2(5), CHUK(3), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), G6PC(2), G6PC2(3), IKBKB(5), IRS1(1), IRS2(2), IRS4(10), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), MAPK10(3), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIB(1), NPY(2), PCK2(3), POMC(1), PPARGC1A(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2), PRKAG3(2), PRKCQ(5), PTPN11(1), RELA(1), RXRA(4), RXRB(2), RXRG(6), SLC2A1(3), SLC2A4(1), STAT3(3), STK11(2), TRAF2(1), TYK2(2)	37823107	177	120	176	56	26	36	59	31	25	0	0.320	1.000	1.000
379	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(8), AGTR2(2), ATP8A1(9), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(2), MC2R(7), MC3R(3), MC4R(3), MC5R(5), NMBR(2), NPY1R(5), NPY2R(3), NPY5R(7), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), PPYR1(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TACR1(2), TACR2(2), TACR3(5), TRHR(4), TSHR(2)	23840888	162	115	162	62	29	38	54	22	19	0	0.223	1.000	1.000
380	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(2), CHN1(3), LIMK1(5), MAP3K1(3), MYLK(4), NCF2(4), PAK1(1), PDGFRA(6), PIK3CA(64), PIK3R1(6), PLD1(7), PPP1R12B(1), RAC1(10), RALBP1(2), RPS6KB1(3), TRIO(10), VAV1(2), WASF1(3)	15923225	136	109	93	33	10	60	32	28	6	0	0.0111	1.000	1.000
381	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(9), BAG4(4), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(25), CFLAR(2), CHUK(3), CRADD(1), FADD(1), GSN(5), LMNB1(1), LMNB2(4), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK8(4), MDM2(2), NFKB1(2), NUMA1(4), PAK2(5), PRKCD(4), PRKDC(15), PTK2(5), RASA1(14), RB1(9), RELA(1), RIPK1(2), SPTAN1(11), TRAF2(1)	31565281	155	108	150	39	19	27	37	24	48	0	0.0836	1.000	1.000
382	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	CD14(1), CD19(2), CD1A(4), CD1B(1), CD1C(2), CD1D(4), CD1E(8), CD2(1), CD22(1), CD33(2), CD34(4), CD38(2), CD3D(1), CD44(1), CD7(2), CD8A(2), CD8B(1), CD9(1), CR1(8), CR2(5), CSF1(1), CSF2RA(1), CSF3R(2), EPO(2), FCER2(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(3), GP9(1), GYPA(3), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL7R(3), IL9R(4), ITGA1(3), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(5), KIT(5), MME(11), MS4A1(2), TFRC(3), TPO(10)	37192773	164	108	163	62	26	36	59	27	16	0	0.752	1.000	1.000
383	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(2), AMY2B(6), ENPP1(5), ENPP3(5), G6PC(2), GAA(3), GANAB(1), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), MGAM(18), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), SI(40), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UXS1(1)	25874629	158	107	157	55	21	28	55	35	19	0	0.736	1.000	1.000
384	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ITPA(3), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), PNPT1(4), POLA1(2), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PRIM2(9), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(3), TXNRD2(1), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UPB1(1), UPP1(1), UPP2(4), UPRT(2)	36879615	146	104	146	59	25	27	52	22	20	0	0.894	1.000	1.000
385	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(2), CCKBR(3), CCR2(2), CCR3(3), CELSR1(9), CELSR2(18), CELSR3(12), CHRM2(4), CHRM3(5), CXCR3(1), DRD4(1), EMR2(2), EMR3(2), FSHR(5), GHRHR(2), GPR116(4), GPR132(2), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR55(1), GPR77(2), GPR84(2), GRM1(16), GRPR(1), HRH4(3), LGR6(5), LPHN2(8), LPHN3(14), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(3), P2RY13(2), PTGFR(2), SMO(1), SSTR2(1), TSHR(2), VN1R1(1)	30291802	160	103	160	62	25	45	51	27	12	0	0.337	1.000	1.000
386	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ADAM17(4), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(14), F11R(1), GIT1(1), IGSF5(3), IKBKB(5), LYN(3), MAP2K4(1), MAP3K14(2), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MET(1), NFKB1(2), NFKB2(1), NOD1(5), PAK1(1), PLCG1(5), PLCG2(4), PTPN11(1), PTPRZ1(6), RAC1(10), RELA(1), SRC(1), TCIRG1(7), TJP1(9)	32024790	142	100	140	44	14	33	48	30	17	0	0.399	1.000	1.000
387	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(2), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(14), GRAP2(1), ITK(1), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(1), MAPK1(4), NCK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLCG1(5), PTPRC(13), RAF1(2), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), SOS1(8), SOS2(9), VAV1(2), ZAP70(2)	25462763	132	100	127	38	20	26	40	21	25	0	0.224	1.000	1.000
388	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(3), ACOX2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ANGPTL4(3), APOA2(1), APOA5(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(8), CYP4A22(6), CYP7A1(2), CYP8B1(3), DBI(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(2), FABP5(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(7), HMGCS2(2), ILK(4), LPL(2), ME1(1), MMP1(4), OLR1(1), PCK2(3), PDPK1(2), RXRA(4), RXRB(2), RXRG(6), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(5), SORBS1(2), UBC(4)	29828246	136	99	136	42	21	27	49	16	23	0	0.252	1.000	1.000
389	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(4), ASAH1(1), BRAF(4), DAG1(1), DRD2(2), EGFR(14), EPHB2(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PI3(1), PIK3CB(5), PITX2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), RAF1(2), RGS20(2), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT3(3)	26560548	139	99	135	43	21	29	42	33	14	0	0.240	1.000	1.000
390	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(3), CCND1(2), CREBBP(15), EP300(25), ERCC3(4), ESR1(3), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), MEF2C(7), NCOR2(11), NR0B1(3), NRIP1(3), PELP1(1), POLR2A(9), TBP(1)	20929634	121	97	118	38	10	30	40	21	20	0	0.372	1.000	1.000
391	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), HSD17B4(3), NSD1(36), OGDH(6), OGDHL(9), PIPOX(1), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(1), RDH12(3), SETD1A(6), SETD7(2), SETDB1(6), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(2), TMLHE(2)	26417001	138	97	138	44	18	23	40	23	32	2	0.519	1.000	1.000
392	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), AFMID(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CARM1(3), CAT(2), CYP1A2(4), CYP1B1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HEMK1(1), HSD17B4(3), KMO(1), KYNU(6), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), NFX1(2), OGDH(6), OGDHL(9), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), TDO2(2), TPH1(2), TPH2(4), WARS2(5)	27547564	124	95	124	38	20	26	36	18	24	0	0.343	1.000	1.000
393	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BTRC(1), CSNK1A1(1), CSNK1E(3), CSNK1G1(1), GLI1(5), GLI2(8), GLI3(5), GSK3B(1), HHIP(2), LRP2(26), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(11), PTCH2(5), RAB23(2), SMO(1), STK36(4), SUFU(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1), ZIC2(5)	27678560	132	95	132	47	29	22	50	17	14	0	0.542	1.000	1.000
394	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(15), AXIN1(5), CCND1(2), CSNK1E(3), CTNNB1(2), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LDLR(3), MAPK10(3), MAPK9(4), MYC(4), PLAU(1), PPP2R5C(2), PPP2R5E(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), RAC1(10), RHOA(4), SFRP4(8), TCF7(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1)	27339419	146	95	141	52	20	29	58	27	11	1	0.563	1.000	1.000
395	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CAT(2), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), KMO(1), KYNU(6), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS2(5)	25058904	116	90	116	34	18	23	37	17	21	0	0.205	1.000	1.000
396	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), CARM1(3), DBH(4), DCT(1), DDC(7), ESCO1(3), ESCO2(3), FAH(1), GOT1(1), GOT2(3), HEMK1(1), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), MYST3(4), MYST4(6), PNMT(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SH3GLB1(2), TAT(1), TH(2), TPO(10), TYR(4), TYRP1(1)	27085348	118	89	117	39	21	30	37	13	17	0	0.418	1.000	1.000
397	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CEL(1), DAK(3), DGAT2(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), GK(1), GK2(7), GLA(3), GLB1(4), GPAM(3), LCT(8), LIPA(1), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1)	26704718	119	87	119	32	17	28	29	26	19	0	0.0611	1.000	1.000
398	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), ITGB1(12), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2)	23930095	116	87	112	42	25	25	38	11	16	1	0.471	1.000	1.000
399	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), ITGB1(12), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2)	23930095	116	87	112	42	25	25	38	11	16	1	0.471	1.000	1.000
400	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(2), CALM1(1), CALM3(1), FLT1(10), FLT4(6), KDR(5), NOS3(4), PDE2A(1), PDE3A(13), PDE3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(3), PRKG2(1), RYR2(44), SLC7A1(2), SYT1(5)	18432057	109	86	109	41	20	26	36	18	8	1	0.646	1.000	1.000
401	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHFR(3), DHX58(2), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), FPGS(2), IFIH1(5), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(8), SMARCA5(1)	28632935	104	85	104	31	12	21	39	20	12	0	0.389	1.000	1.000
402	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(3), EGF(6), EGFR(14), ETS1(2), ETS2(5), FOS(1), HOXA7(2), HRAS(11), IKBKB(5), MAP2K1(4), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK1(4), MAPK13(3), MAPK14(1), MAPK8(4), NFKB1(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), RAF1(2), RELA(1), RIPK1(2), SP1(1), TRAF2(1)	22378222	113	85	105	38	22	20	37	17	17	0	0.519	1.000	1.000
403	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(3), GAPDHS(1), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGAM4(1), PGK2(3), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	26472566	107	84	107	40	20	21	28	17	21	0	0.688	1.000	1.000
404	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(6), ADCY4(5), ADCY6(4), ADCY8(13), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(3), GNB1(2), GNB3(3), GRM4(2), ITPR3(5), KCNB1(3), PDE1A(3), PLCB2(4), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), SCNN1A(3), SCNN1B(1), SCNN1G(4), TAS1R1(2), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(1), TAS2R40(4), TAS2R42(1), TAS2R43(1), TAS2R46(2), TAS2R60(1), TAS2R7(2), TAS2R8(3), TRPM5(3)	25874670	119	84	119	60	34	18	28	26	13	0	0.943	1.000	1.000
405	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(7), CALR(2), CD74(3), CD8A(2), CD8B(1), CIITA(7), CREB1(1), CTSS(3), HLA-A(9), HLA-B(10), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), HSP90AA1(6), HSP90AB1(7), HSPA5(3), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), KIR2DL1(3), KIR2DL3(1), KIR2DS4(1), KIR3DL1(7), KIR3DL3(2), KLRC2(1), KLRC3(2), KLRC4(1), LGMN(3), LTA(1), NFYC(2), PSME1(1), PSME2(1), RFX5(4), RFXAP(1), TAP1(3), TAP2(5), TAPBP(1)	21129955	122	83	119	36	9	26	31	21	34	1	0.228	1.000	1.000
406	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2A1(1), BCL2L1(2), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(25), CD40(4), CD40LG(3), CRADD(1), FADD(1), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(2), NGFR(1), NR3C1(5), NTRK1(3), PTPN13(9), RIPK1(2), SFRS2IP(5), TFG(1), TRAF2(1), TRAF3(3), TRAF6(1)	19828057	98	82	95	22	17	20	18	20	23	0	0.0348	1.000	1.000
407	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ITPA(3), NUDT2(1), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), RRM1(1), RRM2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(1)	26116929	106	82	106	37	16	20	40	14	16	0	0.493	1.000	1.000
408	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), AKR1D1(2), ARSD(1), ARSE(1), CARM1(3), CYP11B1(4), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3)	22848351	108	80	108	37	18	20	43	18	9	0	0.588	1.000	1.000
409	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), ALDH3B1(1), ALDH3B2(2), CYP1A2(4), CYP1B1(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2F1(2), CYP2S1(1), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), EPHX1(1), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3)	26186719	122	80	121	42	13	26	49	24	10	0	0.514	1.000	1.000
410	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CHPT1(1), CRLS1(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), ESCO1(3), ESCO2(3), ETNK2(1), GNPAT(3), GPAM(3), GPD1(1), GPD2(2), LCAT(2), MYST3(4), MYST4(6), PCYT1A(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(7), PLD2(1), PPAP2B(1), PTDSS1(5), PTDSS2(1), SH3GLB1(2)	29766289	112	79	112	36	12	22	35	21	22	0	0.430	1.000	1.000
411	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(21), B3GALT4(3), CDR1(3), DGKI(8), IL6ST(2), MRPL19(1), PIGK(4), RPL10(2), RPL12(1), RPL13A(1), RPL18(2), RPL22(2), RPL23(1), RPL26(1), RPL28(1), RPL31(1), RPL36(2), RPL37(1), RPL3L(1), RPL4(1), RPL6(2), RPLP0(2), RPLP2(1), RPS10(1), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBA52(2), UBB(1), UBC(4)	23815448	107	79	106	46	12	21	45	13	16	0	0.969	1.000	1.000
412	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(3), ACTR2(1), AKT1(2), ANGPTL2(2), CDC42(1), CFL1(2), FLNA(8), FLNC(7), FSCN1(1), FSCN3(5), GDI1(2), GDI2(2), LIMK1(5), MYH2(16), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), RHO(3), ROCK1(11), ROCK2(6), VASP(1), WASF1(3), WASL(1)	21807472	108	79	108	38	15	35	28	19	11	0	0.310	1.000	1.000
413	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), CEL(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GK(1), GLA(3), GLB1(4), LCT(8), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1)	21937918	97	76	97	27	15	22	20	21	19	0	0.0891	1.000	1.000
414	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(11), ACACB(12), ACAT2(1), ACOT12(2), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(1), ME2(1), ME3(6), PC(7), PCK2(3), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3)	21292840	90	76	90	36	25	17	26	15	7	0	0.781	1.000	1.000
415	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(6), ATP4A(3), ATP4B(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(1), COX15(2), COX17(2), COX5B(1), COX7B2(1), COX8A(1), LHPP(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(1), NDUFA9(1), NDUFB10(1), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB9(1), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS7(1), NDUFS8(1), NDUFV1(1), PPA1(1), SDHA(5), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRFS1(3)	25453896	90	73	90	31	10	23	27	17	13	0	0.480	1.000	1.000
416	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), F10(3), F11(2), F12(1), F2(2), F5(12), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), PROS1(5), SERPINC1(3), SERPING1(3)	20236242	93	73	93	25	6	28	32	13	14	0	0.322	1.000	1.000
417	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACADVL(4), ACAT2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP4A11(8), CYP4A22(6), DCI(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HADHB(2), HSD17B4(3), PECI(1)	22294292	95	72	95	29	9	25	26	21	14	0	0.345	1.000	1.000
418	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(2), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), F2(2), FYN(3), GNAI1(1), GNB1(2), HRAS(11), JAK2(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK14(1), MAPK8(4), MAPT(6), MYLK(4), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), SYT1(5)	18922261	93	71	84	23	15	18	36	15	9	0	0.0813	1.000	1.000
419	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(4), ARHGEF11(3), BCL2(1), CDC42(1), DLG4(1), GNA13(1), LPA(8), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK8(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(5), PLD1(7), PLD2(1), PLD3(1), PTK2(5), ROCK1(11), ROCK2(6), SERPINA4(5), TBXA2R(1)	22402792	95	71	95	35	9	26	29	15	16	0	0.720	1.000	1.000
420	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(2), APC(15), ASAH1(1), DAG1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PITX2(1), PTX3(2), RAC1(10), RHO(3), RYR1(16)	20762040	93	71	88	34	22	23	22	15	11	0	0.383	1.000	1.000
421	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	22234026	86	70	86	36	16	18	21	14	17	0	0.846	1.000	1.000
422	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CLC(2), CPT1B(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GNPAT(3), GPD1(1), GPD2(2), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB2(4), PLCG1(5), PLCG2(4), PPAP2B(1)	22761376	87	70	87	26	10	13	25	19	20	0	0.265	1.000	1.000
423	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	22234026	86	70	86	36	16	18	21	14	17	0	0.846	1.000	1.000
424	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN2(4), CAPNS1(1), CAPNS2(2), CXCR3(1), EGF(6), EGFR(14), HRAS(11), ITGA1(3), ITGB1(12), MAPK1(4), MYLK(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(5), PXN(1), TLN1(13)	14883507	91	70	82	28	18	16	31	15	11	0	0.338	1.000	1.000
425	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(4), ANKRD6(2), APC(15), AXIN1(5), AXIN2(5), CSNK1A1(1), CTNNB1(2), DACT1(3), DKK1(3), DKK2(3), DKK3(2), DVL1(2), FSTL1(3), GSK3B(1), LRP1(17), MVP(3), NKD1(5), NKD2(1), PIN1(1), PTPRA(4), SENP2(2), SFRP1(1)	18399429	90	70	90	32	10	30	22	18	9	1	0.398	1.000	1.000
426	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), CREB1(1), ELK1(1), HRAS(11), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK14(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MYC(4), PLA2G4A(3), RAC1(10), RIPK1(2), RPS6KA5(4), SHC1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1)	16659441	79	68	72	23	11	19	29	10	10	0	0.305	1.000	1.000
427	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GAPDHS(1), GCK(2), GOT1(1), GOT2(3), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MDH1(1), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGK2(3), PKLR(1), PKM2(3), TNFAIP1(2), TPI1(2)	19321716	84	67	84	32	21	14	24	14	11	0	0.637	1.000	1.000
428	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(3), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), FUK(1), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), LHPP(1), MPI(3), MTMR2(5), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB4(2), PFKL(4), PFKM(2), PFKP(4), PGM2(1), PHPT1(1), RDH11(1), RDH12(3), SORD(1), TPI1(2), TSTA3(2)	16906477	73	66	73	19	17	9	25	12	10	0	0.154	1.000	1.000
429	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(2), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALNT1(2), B4GALT2(3), B4GALT6(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GBGT1(2), GCNT2(4), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(4), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4), UGCG(1)	22103183	85	66	85	32	11	21	29	13	11	0	0.512	1.000	1.000
430	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(8), AR(4), ESR1(3), ESR2(1), ESRRA(4), HNF4A(2), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(2), NR1I2(2), NR2C2(1), NR2E1(3), NR2F1(2), NR2F2(4), NR3C1(5), NR4A2(2), NR5A2(2), PGR(2), RARA(2), RARB(2), RARG(5), ROR1(5), RORA(1), RORC(2), RXRA(4), RXRB(2), RXRG(6), THRA(4), THRB(1), VDR(1)	19120352	87	66	85	32	18	13	30	11	15	0	0.669	1.000	1.000
431	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(2), ARHGAP4(5), ARHGAP5(6), ARHGAP6(6), ARHGEF1(5), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(2), ARPC4(1), CFL1(2), DIAPH1(6), GSN(5), LIMK1(5), MYLK(4), PIP5K1A(4), PIP5K1B(4), PPP1R12B(1), ROCK1(11), SRC(1), TLN1(13), VCL(6)	20642161	97	66	97	37	11	26	32	22	6	0	0.727	1.000	1.000
432	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(3), ACY3(3), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(2), AOC3(5), ASPA(1), CARM1(3), CNDP1(3), DDC(7), FTCD(1), HAL(2), HARS2(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), PRPS1(3), PRPS2(1), UROC1(3)	18011757	77	65	77	20	16	22	24	5	10	0	0.0515	1.000	1.000
433	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(4), BLVRA(2), COX10(1), COX15(2), CP(4), CPOX(1), EARS2(1), EPRS(2), FECH(1), FTMT(4), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), UROD(1), UROS(3)	19248154	83	65	83	35	7	14	40	20	2	0	0.932	1.000	1.000
434	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(1), GTF2H4(1), GTF2I(3), GTF2IRD1(3), TAF1(8), TAF10(4), TAF1L(13), TAF2(5), TAF4(2), TAF4B(4), TAF5(5), TAF5L(1), TAF6(3), TAF7(1), TAF7L(2), TAF9(2), TBPL1(2), TBPL2(1)	16412255	75	63	75	25	6	20	24	13	12	0	0.620	1.000	1.000
435	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(1), POLB(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLG(2), POLG2(1), POLH(2), POLI(2), POLK(3), POLL(5), POLM(1), POLQ(16), PRIM2(9), REV1(1), REV3L(11), RFC5(2)	18438079	75	63	75	24	9	20	21	10	15	0	0.501	1.000	1.000
436	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC23(1), CDC27(5), CUL1(6), CUL2(1), CUL3(10), FBXW7(14), FZR1(2), ITCH(5), RBX1(2), SKP1(1), SKP2(2), SMURF1(2), SMURF2(4), TCEB1(1), UBE2D2(1), UBE2E1(1), WWP1(3), WWP2(2)	18239486	75	63	73	19	9	18	18	17	13	0	0.268	1.000	1.000
437	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(2), AKT2(3), AKT3(4), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PIK3CB(5), PITX2(1), PLD1(7), PLD2(1), PLD3(1), VN1R1(1)	20370491	76	62	76	32	8	26	15	14	13	0	0.688	1.000	1.000
438	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(11), ACACB(12), ACADM(3), ACAT2(1), ACSS1(5), ACSS2(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3)	18088116	76	61	76	26	16	15	23	12	10	0	0.601	1.000	1.000
439	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(11), ACAT2(1), ACYP1(1), ADH5(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(1), ME2(1), ME3(6), PC(7), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3)	16825998	68	61	68	25	20	13	16	14	5	0	0.591	1.000	1.000
440	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), DBH(4), DCT(1), DDC(7), FAH(1), GOT1(1), GOT2(3), HGD(2), HPD(1), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(2), TPO(10), TYR(4)	14444053	71	61	70	27	12	19	22	7	11	0	0.554	1.000	1.000
441	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(2), ABAT(5), ACADS(2), ACAT2(1), ACSM1(2), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), ILVBL(3), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(3), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(3)	18485529	73	60	73	33	11	16	24	14	8	0	0.906	1.000	1.000
442	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(3), CARS(2), DARS(2), DARS2(1), EARS2(1), EPRS(2), FARS2(2), FARSB(4), GARS(1), HARS2(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), MTFMT(3), NARS(2), NARS2(1), PARS2(3), QARS(1), RARS(1), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(1), VARS(5), VARS2(1), WARS2(5), YARS(3), YARS2(3)	24731006	74	60	73	28	8	15	30	15	6	0	0.788	1.000	1.000
443	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), CHRM2(4), CHRM3(5), CHRM5(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), HRH1(1), HRH2(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3)	11657802	71	60	71	34	16	10	25	16	4	0	0.718	1.000	1.000
444	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(6), ADRBK2(4), ARRB2(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(5), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(9), GNAL(2), PDC(1), PDE1C(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKG1(3), PRKG2(1), PRKX(1)	13896049	68	59	68	27	13	13	18	16	8	0	0.653	1.000	1.000
445	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDT1(1), DIAPH2(6), GMNN(1), MCM10(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), RFC1(2), RFC2(2), RFC3(1), RFC4(4), RFC5(2), RPA1(4), RPS27A(1), UBA52(2), UBB(1), UBC(4)	23074021	79	58	78	38	8	20	34	7	10	0	0.984	1.000	1.000
446	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), PON1(6)	13347882	69	58	69	20	10	11	28	13	7	0	0.273	1.000	1.000
447	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), BTG1(1), CBX3(1), CEBPB(1), CLOCK(4), CRY1(3), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(2), ETV6(4), G0S2(1), GFRA1(6), HERPUD1(3), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(5), NCOA4(2), NR1D2(2), PER1(5), PER2(2), PPP1R3C(1), PPP2CB(1), TUBB3(2), UCP3(3), UGP2(1), VAPA(1), ZFR(3)	16654955	65	57	65	25	9	13	27	10	6	0	0.818	1.000	1.000
448	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(3), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GCNT1(1), GCNT4(2), OGT(3), ST3GAL1(1), ST6GALNAC1(4), WBSCR17(8)	14694128	78	57	78	27	14	16	23	11	14	0	0.585	1.000	1.000
449	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(6), ATP4B(2), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(8), ATP7B(4), COX10(1), COX5B(1), COX8A(1), NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1), SDHA(5), SHMT1(1), UQCRC1(1), UQCRFS1(3)	17384861	63	57	63	21	6	18	17	15	7	0	0.420	1.000	1.000
450	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(3), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SHMT1(1), SHMT2(2), TMLHE(2)	16863752	66	56	66	31	13	13	17	12	11	0	0.887	1.000	1.000
451	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA2(1), ACADM(3), ACADS(2), ACAT2(1), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOX1(5), AUH(1), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(5), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), OXCT2(1), PCCA(5), PCCB(1)	19616344	67	55	67	24	12	18	18	11	8	0	0.638	1.000	1.000
452	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(9), BMPR1B(1), CDK4(4), CDKN1B(2), CEBPB(1), DMC1(2), EGR1(3), ESR2(1), FSHR(5), INHA(1), LHCGR(2), MLH1(4), MSH5(1), NCOR1(12), NRIP1(3), PGR(2), PRLR(4), PTGER2(4), SMPD1(1), VDR(1), ZP2(4)	15955331	67	55	65	18	7	15	24	13	8	0	0.277	1.000	1.000
453	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(11), ACADL(2), ACADM(3), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), LDHA(1), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3)	15097273	60	55	60	17	13	11	18	9	9	0	0.360	1.000	1.000
454	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(1), CRHR2(4), ELTD1(6), EMR1(5), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(5), LPHN2(8), LPHN3(14), VIPR2(3)	12129177	68	54	68	22	7	7	24	22	8	0	0.506	1.000	1.000
455	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(3), ABAT(5), ACY3(3), ADSL(4), ADSS(2), ADSSL1(2), AGXT2(2), ASNS(4), ASPA(1), ASRGL1(1), ASS1(1), CAD(2), DARS(2), DARS2(1), DLAT(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), NARS2(1), PC(7), PDHA1(3), PDHA2(5)	17243718	64	54	64	29	12	18	21	8	5	0	0.824	1.000	1.000
456	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), ESCO1(3), ESCO2(3), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), MYST3(4), MYST4(6), PRDX6(1), SH3GLB1(2), TAT(1), TPO(10)	15581425	67	54	66	32	13	13	27	5	9	0	0.931	1.000	1.000
457	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(3), ADCY3(6), ADCY9(4), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(2), GNAS(6), PLCG1(5), PLCG2(4), PRKCA(2), SEC61A1(3), SEC61A2(2), SEC61B(1), TRIM23(1)	16815893	68	54	68	20	13	13	22	11	9	0	0.232	1.000	1.000
458	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(4), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), ILK(4), MNAT1(2), POLR1A(5), POLR1B(3), POLR2A(9), POLR2B(2), POLR2G(2), POLR2H(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3H(1), TAF5(5), TAF6(3), TAF7(1), TAF9(2), TBP(1)	15971986	59	54	59	24	8	15	17	7	12	0	0.782	1.000	1.000
459	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF2(1), EEF2K(4), EIF2AK1(6), EIF2AK3(1), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(4), KIAA0664(4), PABPC3(7), PAIP1(4)	19913415	69	54	66	20	8	10	23	12	16	0	0.699	1.000	1.000
460	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(3), AGMAT(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(3), NOS3(4), ODC1(1), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(2)	20123489	68	53	68	26	17	16	18	11	6	0	0.577	1.000	1.000
461	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(15), AXIN1(5), BTRC(1), CCND1(2), CREBBP(15), CSNK1A1(1), CSNK2A1(6), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MYC(4), NLK(1), TLE1(4), WNT1(1)	13396234	68	53	68	21	4	16	24	10	13	1	0.520	1.000	1.000
462	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(1), RPE(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), XYLB(2)	12441231	62	52	62	23	7	10	27	16	2	0	0.793	1.000	1.000
463	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(3), ACADL(2), ACADM(3), ACADSB(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), MLYCD(1), SMS(2), UPB1(1)	13246982	64	51	64	20	10	17	18	9	10	0	0.361	1.000	1.000
464	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(3), AGXT2(2), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CPT1B(3), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PLCB2(4), PLCG1(5), PLCG2(4), SARDH(5), SARS(1), SHMT1(1), SHMT2(2), TARS(3)	19087059	61	50	61	29	12	12	25	5	7	0	0.845	1.000	1.000
465	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(1), AGT(2), AGTR1(8), AGTR2(2), CMA1(3), CPA3(2), CTSG(1), ENPEP(11), LNPEP(2), MAS1(3), MME(11), NLN(2), REN(3)	9641447	56	50	56	20	9	7	24	11	5	0	0.646	1.000	1.000
466	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(7), C5(5), C6(12), C7(5), ICAM1(2), IL1A(1), ITGA4(6), ITGAL(3), ITGB1(12), ITGB2(2), SELP(11), VCAM1(3)	11313717	69	50	68	25	7	17	21	12	12	0	0.592	1.000	1.000
467	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(1), NCOA1(4), NCOA2(3), NCOA3(5), NCOR2(11), POLR2A(9), RARA(2), RXRA(4), TBP(1)	11377258	55	50	55	17	7	12	22	8	6	0	0.464	1.000	1.000
468	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(2), AGTR1(8), AGTR2(2), CMA1(3), COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), REN(3)	11498508	55	49	55	22	5	19	19	7	5	0	0.881	1.000	1.000
469	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(1), CAD(2), CPS1(11), EARS2(1), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GNPNAT1(1), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1)	18015965	60	49	60	30	12	14	17	14	3	0	0.942	1.000	1.000
470	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), CS(2), DLAT(2), DLST(4), FH(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PDK1(1), PDK4(4), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3)	12919449	55	49	55	22	7	11	21	9	7	0	0.778	1.000	1.000
471	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(1), MAPK8(4), MYEF2(3), PLD1(7), PLD2(1), PLD3(1), PTK2(5), RAF1(2), RASAL1(5), SRC(1), TEC(2), VAV1(2)	12511791	55	49	52	18	7	10	18	8	12	0	0.532	1.000	1.000
472	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(3), ELK1(1), FOS(1), IKBKB(5), IRAK1(2), LY96(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TLR2(1), TLR3(1), TLR4(7), TLR6(3), TLR7(4), TLR9(2), TRAF6(1)	16629202	55	49	55	21	8	8	24	8	7	0	0.797	1.000	1.000
473	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOX1(5), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), PCCA(5), PCCB(1)	16411285	54	49	54	20	8	12	16	8	10	0	0.723	1.000	1.000
474	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), OGDHL(9), PC(7), PCK2(3), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3)	13606372	57	48	57	19	8	11	18	13	7	0	0.482	1.000	1.000
475	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), LIPA(1), RDH11(1), RDH12(3), SLC27A5(2), SOAT1(3), SOAT2(2), SRD5A2(2)	14411602	58	47	58	20	9	14	22	8	5	0	0.514	1.000	1.000
476	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(3), AGXT2(2), AKR1B10(3), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PHGDH(1), PIPOX(1), RDH11(1), RDH12(3), SARDH(5), SARS(1), SARS2(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(1)	19401255	57	47	57	25	11	12	25	3	6	0	0.746	1.000	1.000
477	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(3), ACADM(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(1)	12311011	57	47	57	19	9	17	15	9	7	0	0.410	1.000	1.000
478	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(1), FUCA1(1), GALNS(1), GBA(2), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NAGLU(1), NEU1(1), NEU2(1), SPAM1(2)	15650075	50	47	50	20	10	10	12	11	7	0	0.654	1.000	1.000
479	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM3(1), DLG4(1), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), NOS1(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(5)	11640690	57	47	57	23	11	15	18	10	3	0	0.588	1.000	1.000
480	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), GCK(2), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), MPI(3), PFKFB1(4), PFKFB4(2), PFKM(2), PFKP(4), SORD(1), TPI1(2)	10869121	47	46	47	15	9	7	17	7	7	0	0.419	1.000	1.000
481	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(3), E2F4(1), ETS1(2), ETS2(5), FOS(1), HDAC5(1), HRAS(11), NCOR2(11), RBL1(8), RBL2(3), SIN3A(2), SIN3B(5)	11862901	54	45	49	16	9	15	19	6	5	0	0.175	1.000	1.000
482	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG5(1), ALG6(2), ALG9(1), B4GALT2(3), DHDDS(2), DOLPP1(1), DPAGT1(1), DPM1(2), FUT8(2), GANAB(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(2)	19334839	55	45	55	25	10	7	21	9	8	0	0.893	1.000	1.000
483	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(1), DEGS2(1), ENPP7(4), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SGMS1(1), SGMS2(1), SGPP1(2), SMPD1(1), SMPD2(1), SMPD3(1), SMPD4(3), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(1)	16282181	51	45	51	19	10	12	12	10	7	0	0.467	1.000	1.000
484	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(19), CTNNB1(2), PTK2(5), PXN(1), SRC(1), VCL(6)	8727281	56	44	56	23	5	11	23	8	8	1	0.870	1.000	1.000
485	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), PRDX2(1), PRDX6(1), TAT(1), TPO(10)	10002009	50	44	49	23	12	10	19	3	6	0	0.716	1.000	1.000
486	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(3), CYP4F3(1), EPX(5), GGT1(1), MPO(5), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PRDX2(1), PRDX6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5), TPO(10)	12736158	56	44	55	25	13	10	19	8	6	0	0.719	1.000	1.000
487	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), P4HB(1), SLC23A1(3), SLC23A2(5), SLC2A1(3), SLC2A3(2)	11395523	50	44	50	21	4	19	16	6	5	0	0.869	1.000	1.000
488	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(2), ARSB(1), ARSD(1), ARSE(1), CYP11B1(4), CYP11B2(3), HSD11B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8)	12401080	49	43	49	24	9	8	19	10	3	0	0.930	1.000	1.000
489	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(3), C1S(3), C3(7), C5(5), C6(12), C7(5), C8A(6), C8B(4), C9(5), MASP1(4)	9495654	54	43	54	20	2	18	17	9	8	0	0.646	1.000	1.000
490	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(3), C1S(3), C3(7), C5(5), C6(12), C7(5), C8A(6), C9(5), MASP1(4), MASP2(4), MBL2(2)	9729844	56	43	56	18	2	19	16	11	8	0	0.447	1.000	1.000
491	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(1), CAD(2), CPS1(11), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), GMPS(4), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1)	15140759	51	43	51	23	9	13	13	13	3	0	0.859	1.000	1.000
492	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASS1(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), EPRS(2), GATM(2), GLUD1(2), GLUD2(4), GOT1(1), GOT2(3), LAP3(1), NOS1(3), NOS3(4), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	16376141	55	43	55	17	15	9	15	15	1	0	0.402	1.000	1.000
493	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(4), ASRGL1(1), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), HAL(2)	9675351	50	43	50	15	11	13	12	12	2	0	0.352	1.000	1.000
494	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(3), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IRAK1(2), IRAK2(2), IRAK3(4), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TGFB1(1), TGFB2(2), TRAF6(1)	13545349	49	43	49	14	9	11	14	7	8	0	0.366	1.000	1.000
495	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFAT5(5), PDE6A(1), PDE6C(2), SLC6A13(3), TF(3)	16196113	52	42	52	21	5	18	12	10	7	0	0.636	1.000	1.000
496	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM3(1), CHUK(3), EGR2(1), MAP3K1(3), MYC(4), NFATC1(7), NFATC2(6), NFKB1(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), SYT1(5), VIP(1), VIPR2(3)	12742226	51	42	51	19	12	9	15	12	3	0	0.521	1.000	1.000
497	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), ASS1(1), CPS1(11), GATM(2), MAOA(1), MAOB(1), NAGS(2), ODC1(1), OTC(1), SAT1(3), SAT2(1), SMS(2)	13395037	50	41	50	15	11	14	14	6	5	0	0.261	1.000	1.000
498	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(5), GNA12(1), GNA13(1), GNB1(2), MYLK(4), PLCB1(12), PPP1R12B(1), PRKCA(2), ROCK1(11)	9422362	45	41	45	13	7	10	15	9	4	0	0.436	1.000	1.000
499	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOC1(1), CETP(2), CYP7A1(2), HMGCR(3), LCAT(2), LDLR(3), LIPC(3), LPL(2), LRP1(17), SCARB1(1), SOAT1(3)	12484942	45	41	45	13	5	10	15	9	6	0	0.353	1.000	1.000
500	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), AOC2(2), AOC3(5), ASPA(1), CNDP1(3), DDC(7), HAL(2), HDC(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(1)	11101012	45	40	45	13	8	11	14	4	8	0	0.234	1.000	1.000
501	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CHIT1(2), CTBS(1), CYB5R1(1), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(3), HK1(3), HK2(5), HK3(4), LHPP(1), MTMR2(5), MTMR6(2), NANS(2), PGM3(1), PHPT1(1), RENBP(3), UAP1(2)	13065355	47	40	47	16	10	11	12	5	9	0	0.549	1.000	1.000
502	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(5), ACADS(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(3), PDHA2(5)	11758995	45	39	45	21	7	11	11	6	10	0	0.875	1.000	1.000
503	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(3), AOC2(2), AOC3(5), CES1(4), CES7(2), DDHD1(2), ESCO1(3), ESCO2(3), LIPA(1), MYST3(4), MYST4(6), PLA1A(5), PRDX6(1), SH3GLB1(2)	11562887	45	39	45	17	4	11	18	7	5	0	0.811	1.000	1.000
504	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(5), ADSL(4), ADSS(2), AGXT2(2), ASNS(4), ASPA(1), CAD(2), DARS(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), PC(7)	11884905	42	38	42	17	9	10	14	6	3	0	0.624	1.000	1.000
505	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME3(6), PGK2(3), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7), TPI1(2)	9208910	42	38	42	15	10	7	15	6	4	0	0.573	1.000	1.000
506	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), BST1(2), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT12(3)	9826266	41	38	41	19	5	6	18	8	4	0	0.930	1.000	1.000
507	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), EGF(6), EGFR(14), MET(1), PDGFRA(6), PRKCA(2), SH3GLB1(2), SH3KBP1(6), SRC(1)	8839014	40	37	40	13	4	8	14	8	6	0	0.457	1.000	1.000
508	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(3), C1S(3), C3(7), C5(5), C6(12), C7(5), C8A(6), C9(5)	7993843	46	37	46	17	2	17	15	7	5	0	0.626	1.000	1.000
509	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(4), NDST4(7)	9435294	41	37	41	19	10	7	15	6	3	0	0.836	1.000	1.000
510	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CYP2C19(3), CYP2C9(5), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1)	14092645	48	37	48	21	4	9	19	10	6	0	0.927	1.000	1.000
511	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB1(12), ITGB2(2), SELE(4), SELL(2), SELP(11)	7253618	46	37	45	18	6	8	12	9	11	0	0.738	1.000	1.000
512	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(2), DARS(2), EPRS(2), FARS2(2), GARS(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), NARS(2), QARS(1), RARS(1), SARS(1), TARS(3), WARS2(5), YARS(3)	14571823	42	36	41	17	5	6	19	10	2	0	0.862	1.000	1.000
513	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), AKR1D1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), SOAT2(2), SRD5A2(2)	10577856	42	36	42	17	6	10	14	6	6	0	0.749	1.000	1.000
514	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), CMBL(2), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3)	8202193	43	36	43	19	8	5	15	10	5	0	0.857	1.000	1.000
515	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), NAGLU(1), SPAM1(2)	9290213	38	36	38	12	7	7	10	10	4	0	0.507	1.000	1.000
516	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(4), CPOX(1), EPRS(2), FECH(1), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UROD(1), UROS(3)	12503061	39	36	39	21	4	8	15	11	1	0	0.969	1.000	1.000
517	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CHUK(3), CRADD(1), IKBKB(5), LTA(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP4K2(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TRAF2(1)	11015915	36	36	36	11	6	6	13	6	5	0	0.523	1.000	1.000
518	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(8), CR2(5), FCGR2B(1), HLA-DRA(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13)	6927972	40	35	40	22	3	11	8	8	10	0	0.956	1.000	1.000
519	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(6), IL13(1), IL4(1), IL5(1), JUNB(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(7), NFATC2(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5525405	36	35	36	15	10	8	7	7	4	0	0.467	1.000	1.000
520	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2)	11377238	43	35	43	17	4	11	12	10	6	0	0.833	1.000	1.000
521	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(3), BIN1(1), CALM1(1), CALM3(1), DNM1(1), EPN1(4), EPS15(2), PICALM(3), SYNJ1(6), SYNJ2(4), SYT1(5)	9847906	40	35	40	17	5	6	16	9	4	0	0.888	1.000	1.000
522	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(3), FADD(1), IKBKB(5), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(3), MAP3K14(2), MAP3K7(4), NFKB1(2), RELA(1), RIPK1(2), TLR4(7), TNFAIP3(3), TRAF6(1)	11126084	39	35	39	16	7	8	14	7	3	0	0.738	1.000	1.000
523	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(6), DBH(4), DDC(7), GAD1(2), GAD2(2), HDC(2), MAOA(1), PAH(4), PNMT(1), SLC18A3(3), TH(2), TPH1(2)	6571771	39	34	39	16	5	9	11	5	9	0	0.656	1.000	1.000
524	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16)	7617736	36	34	36	14	6	8	8	5	9	0	0.573	1.000	1.000
525	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(8), EGF(6), EGFR(14), HGS(1), RAB5A(2), TF(3), TFRC(3)	5847123	37	34	37	12	3	10	13	7	4	0	0.587	1.000	1.000
526	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(11), CPT1A(4), LEP(1), LEPR(11), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2)	6592726	37	34	37	17	5	6	13	8	5	0	0.932	1.000	1.000
527	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(7), SDHA(5), SUCLA2(1), SUCLG2(3)	9387222	38	33	38	13	5	9	13	8	3	0	0.445	1.000	1.000
528	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), NCK1(4), NCKAP1(5), NTRK1(3), PIR(1), RAC1(10), WASF1(3), WASF2(2), WASF3(2), WASL(1)	6942248	38	32	36	14	8	11	8	10	1	0	0.607	1.000	1.000
529	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(7), C5(5), C6(12), C7(5), C8A(6), C9(5)	5737115	40	32	40	13	2	13	14	7	4	0	0.569	1.000	1.000
530	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), LHPP(1), MTMR2(5), MTMR6(2), PHPT1(1), TYR(4)	6851614	37	32	37	12	7	4	16	3	7	0	0.752	1.000	1.000
531	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1)	10695384	38	32	38	12	5	10	11	4	8	0	0.445	1.000	1.000
532	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(4), ABCG2(2), BCHE(5), CES1(4), CES2(7), CYP3A4(3), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2)	10406050	36	32	36	23	6	6	15	5	4	0	0.983	1.000	1.000
533	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), ACADS(2), ACADVL(4), ACSL1(2), ACSL3(1), ACSL4(6), CPT1A(4), CPT2(2), DCI(1), EHHADH(2), HADHA(3), SLC25A20(1)	7655447	33	32	33	11	4	7	9	8	5	0	0.574	1.000	1.000
534	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(12), GNAS(6), PLCE1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAP2B(1)	6702553	39	32	39	12	10	7	15	4	3	0	0.423	1.000	1.000
535	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(2), GRM1(16), PLCB1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	7259989	39	31	39	15	6	10	15	8	0	0	0.528	1.000	1.000
536	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GPHN(1), NSF(1), SRC(1), UBQLN1(2)	5449046	35	31	35	14	2	8	14	4	7	0	0.791	1.000	1.000
537	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SMPD1(1), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(1)	10965422	33	31	33	15	5	9	8	5	6	0	0.770	1.000	1.000
538	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(2), ACYP1(1), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), FN3K(2), GCDH(1), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1)	11846896	38	31	38	16	3	7	12	11	5	0	0.884	1.000	1.000
539	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD2(1), CD33(2), CD7(2), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(1), ITGAX(5), TLR2(1), TLR4(7), TLR7(4), TLR9(2)	8478474	34	30	34	16	5	5	12	8	4	0	0.842	1.000	1.000
540	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), OPLAH(2)	10041415	32	30	31	15	4	9	10	7	2	0	0.757	1.000	1.000
541	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(1), COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), ILVBL(3), PANK2(1), PANK4(1), PPCS(2), UPB1(1), VNN1(2)	7897888	35	30	35	17	4	5	16	7	3	0	0.955	1.000	1.000
542	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(6), PTPRU(6), REG1A(8), STAT1(5), STAT2(3), TYK2(2)	5696518	32	30	32	10	4	8	10	4	6	0	0.390	1.000	1.000
543	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F2(2), FGA(7), FGB(2), FGG(3), PLAT(2), PLAU(1), PLG(8), SERPINB2(1), SERPINE1(4)	6104274	33	29	33	11	4	6	12	4	7	0	0.569	1.000	1.000
544	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(11), ACACB(12), FASN(4), MCAT(1), OLAH(2), OXSM(2)	7231847	32	29	32	13	7	8	10	6	1	0	0.615	1.000	1.000
545	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(2), DHFR(3), FTCD(1), GART(3), MTFMT(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	8616231	35	29	35	14	4	6	17	4	4	0	0.788	1.000	1.000
546	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(3), TRH(2), VIP(1)	5059206	32	29	32	14	4	3	17	5	3	0	0.812	1.000	1.000
547	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(5), GLI2(8), GLI3(5), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(1)	7572285	32	29	32	13	5	8	11	6	2	0	0.678	1.000	1.000
548	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(3), HK1(3), HK2(5), HK3(4), PGM3(1), RENBP(3), UAP1(2)	7717229	29	28	29	10	7	7	7	4	4	0	0.536	1.000	1.000
549	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME2(1), ME3(6), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TPI1(2)	8239345	30	28	30	11	9	5	11	4	1	0	0.559	1.000	1.000
550	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	BECN1(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(2), PIK3R4(7), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(2)	9628879	32	28	32	19	5	4	14	8	1	0	0.985	1.000	1.000
551	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22(1), IL22RA1(2), JAK1(6), JAK2(2), JAK3(3), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4), TYK2(2)	8357068	32	28	31	14	2	11	9	5	5	0	0.665	1.000	1.000
552	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(6), ABCB4(9), ABCC3(4)	6520323	30	28	30	15	3	8	12	2	5	0	0.818	1.000	1.000
553	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(2), GALNT2(3), GALNT3(3), GALNT4(2), GALNT6(3), GALNT8(5), GCNT1(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(8)	6580765	31	28	31	14	5	7	10	2	7	0	0.800	1.000	1.000
554	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(1), RPE(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8)	8010556	28	28	28	15	6	3	8	10	1	0	0.932	1.000	1.000
555	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), ESRRA(4), HDAC5(1), MEF2A(1), MEF2B(2), MEF2C(7), SLC2A4(1), SYT1(5), YWHAH(1)	9228378	32	28	31	10	2	9	12	7	2	0	0.426	1.000	1.000
556	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR109B(4), GPR161(3), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR45(3), GPR68(1), GPR75(4), GPR81(2)	4478212	28	27	28	13	8	7	6	6	1	0	0.638	1.000	1.000
557	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGB1(12), ITGB2(2), SELE(4), SELL(2)	5523452	32	27	31	16	6	6	5	6	9	0	0.875	1.000	1.000
558	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(3), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	8139038	31	27	31	14	4	5	15	4	3	0	0.870	1.000	1.000
559	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(3), IKBKB(5), LTA(1), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TNFAIP3(3), TRAF2(1), TRAF3(3)	10244486	28	27	28	10	4	5	7	6	6	0	0.591	1.000	1.000
560	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(3), IFNG(1), IKBKB(5), IL4(1), MAP3K1(3), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF9(1), TRAF2(1)	8870258	30	26	30	13	4	5	11	5	5	0	0.867	1.000	1.000
561	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(2), AGTR1(8), AGTR2(2), KNG1(3), NOS3(4), REN(3)	4501421	27	26	27	13	6	7	7	4	3	0	0.724	1.000	1.000
562	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(7), CD3D(1), GZMB(1), HLA-A(9), ICAM1(2), ITGAL(3), ITGB2(2), PRF1(3)	3992315	28	26	26	12	3	2	3	4	16	0	0.755	1.000	1.000
563	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(1), IARS(7), ILVBL(3), LARS2(1), PDHA1(3), PDHA2(5), VARS(5), VARS2(1)	8506475	26	26	26	16	0	7	11	5	3	0	0.981	1.000	1.000
564	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(2), EPX(5), MPO(5), MTHFR(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10)	5297708	29	26	28	14	11	3	12	2	1	0	0.807	1.000	1.000
565	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), NPAS2(1), NR1D1(1), PER1(5), PER2(2), PER3(8)	7772119	29	26	29	11	6	6	9	6	2	0	0.624	1.000	1.000
566	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(2), EPX(5), MPO(5), PRDX2(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10)	5381448	29	26	28	14	10	3	12	3	1	0	0.807	1.000	1.000
567	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), PANK2(1), PANK4(1), PPCS(2), UPB1(1)	6363188	29	26	29	13	4	4	13	6	2	0	0.914	1.000	1.000
568	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), GBA3(5), MPO(5), PRDX2(1), PRDX6(1), TPO(10), TYR(4)	4402726	31	26	30	15	7	2	16	4	2	0	0.879	1.000	1.000
569	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), PGD(2)	8229452	27	25	26	10	5	7	6	6	3	0	0.540	1.000	1.000
570	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTR(4)	7926355	31	25	30	10	6	7	12	5	1	0	0.383	1.000	1.000
571	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3)	6643280	28	25	28	12	2	5	14	4	3	0	0.881	1.000	1.000
572	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD8A(2), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1)	4902911	27	25	27	16	3	3	4	7	10	0	0.940	1.000	1.000
573	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1)	9258084	25	24	25	13	7	4	5	5	4	0	0.827	1.000	1.000
574	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), IMPA2(2), ISYNA1(2), PGM1(3), PGM3(1), TGDS(2)	5308888	25	24	25	10	5	5	8	3	4	0	0.646	1.000	1.000
575	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL18(2), RPL26(1), RPL28(1), RPL31(1), RPL37(1), RPL37A(1), RPL3L(1), RPL6(2), RPS10(1), RPS13(2), RPS20(1), RPS21(1), RPS23(1), RPS28(1), RPS3(1), RPS5(1)	10315877	26	24	25	10	4	6	11	1	4	0	0.829	1.000	1.000
576	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), JAK2(2), STAT4(3), TYK2(2)	6687738	26	24	26	10	1	7	8	5	5	0	0.656	1.000	1.000
577	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), GBA(2), GBA3(5), MPO(5), PRDX6(1), TPO(10)	3820579	28	23	27	13	7	4	13	3	1	0	0.773	1.000	1.000
578	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT2(3), B4GALT5(2), DPAGT1(1), DPM1(2), FUT8(2), MAN1B1(3), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), RPN1(1), RPN2(2)	9135403	27	23	27	10	5	4	6	7	5	0	0.586	1.000	1.000
579	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1)	7291311	26	23	26	10	5	5	9	3	4	0	0.725	1.000	1.000
580	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), TBXA2R(1)	5099081	23	23	23	12	5	4	11	2	1	0	0.693	1.000	1.000
581	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1)	5143284	25	23	25	17	2	3	4	7	9	0	0.975	1.000	1.000
582	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), ESR1(3), GREB1(11), MTA1(4), MTA3(3), PDZK1(2), TUBA8(2)	4996950	26	22	26	12	7	0	10	6	3	0	0.820	1.000	1.000
583	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(1), CSF1(1), FCGR3A(4), IL1B(1), IL6R(4), SELL(2), SPN(2), TGFB1(1), TGFB2(2), TNFRSF8(1), TNFSF8(2)	6006613	26	22	26	11	6	6	6	6	2	0	0.567	1.000	1.000
584	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(3), CHST1(3), CHST2(2), CHST4(3), CHST6(6), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5735233	25	21	25	14	10	3	8	1	3	0	0.891	1.000	1.000
585	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(4), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1)	10844023	23	21	23	22	4	4	7	4	4	0	0.999	1.000	1.000
586	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1)	7511162	22	21	22	10	6	3	5	5	3	0	0.757	1.000	1.000
587	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(11), MMP14(2), MMP2(2), RECK(6), TIMP1(1)	3418227	22	21	17	10	2	7	9	4	0	0	0.675	1.000	1.000
588	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2)	4183404	20	20	20	11	4	4	8	2	2	0	0.865	1.000	1.000
589	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2)	4183404	20	20	20	11	4	4	8	2	2	0	0.865	1.000	1.000
590	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2)	7553221	23	20	23	14	1	4	10	5	3	0	0.992	1.000	1.000
591	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), RAC1(10), WASF1(3), WASL(1)	3692808	22	20	20	9	5	8	3	6	0	0	0.650	1.000	1.000
592	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), GGCX(3), HMGCR(3), IDI1(1), LSS(3), PMVK(1), SC4MOL(1), TM7SF2(1)	8797914	21	19	21	12	6	5	4	1	5	0	0.919	1.000	1.000
593	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3), RDH11(1), RDH12(3)	4102728	22	19	22	12	1	3	8	9	1	0	0.934	1.000	1.000
594	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(6), STAT1(5), STAT2(3), TYK2(2)	4935436	19	18	19	11	2	6	4	2	5	0	0.907	1.000	1.000
595	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), PCYT1A(1), PDHA1(3), PDHA2(5), SLC18A3(3)	3189313	20	17	20	14	2	4	7	4	3	0	0.976	1.000	1.000
596	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(2), ITGAL(3), ITGAM(3), ITGB2(2), SELE(4), SELL(2)	4720160	17	17	17	15	1	2	4	4	6	0	0.996	1.000	1.000
597	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(12), PRKCA(2), RELA(1)	3759828	17	17	17	7	3	3	8	3	0	0	0.733	1.000	1.000
598	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(4), CPO(2), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3)	3556541	16	16	16	7	2	3	7	4	0	0	0.760	1.000	1.000
599	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), HMGCS1(2), IDI1(1), LSS(3), PMVK(1), SC4MOL(1)	6015011	18	16	18	10	5	5	2	3	3	0	0.897	1.000	1.000
600	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(7), LARS2(1), PDHA1(3), PDHA2(5)	4561919	16	16	16	12	0	4	7	4	1	0	0.996	1.000	1.000
601	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRA(1), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL3(1), IL4(1), IL5(1), LTA(1), TGFB1(1), TGFB2(2)	6055633	17	15	17	12	4	4	2	5	2	0	0.960	1.000	1.000
602	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(11), GLS(1), GLUD1(2), GOT1(1)	3554471	15	15	15	5	3	3	3	6	0	0	0.596	1.000	1.000
603	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(2), NOX1(5), RELA(1), XDH(3)	4517257	13	13	13	10	2	3	3	3	2	0	0.959	1.000	1.000
604	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(4), CPOX(1), FECH(1), UROD(1), UROS(3)	3442046	12	12	12	6	1	3	4	4	0	0	0.835	1.000	1.000
605	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(5), GGT1(1), SHMT1(1), SHMT2(2)	2504290	12	12	12	5	3	2	4	3	0	0	0.767	1.000	1.000
606	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(2)	3147790	12	11	12	11	2	1	6	1	2	0	0.978	1.000	1.000
607	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(5), GGT1(1), SHMT1(1), SHMT2(2)	1887272	9	9	9	5	2	0	4	3	0	0	0.927	1.000	1.000
608	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), CASP7(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(2)	4030067	9	9	9	4	1	3	3	2	0	0	0.804	1.000	1.000
609	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1), GLUD1(2), GLUD2(4)	2078035	8	8	8	4	2	2	2	2	0	0	0.859	1.000	1.000
610	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(1), APOBEC2(1), APOBEC3B(3)	3342125	7	7	7	6	1	1	2	3	0	0	0.974	1.000	1.000
611	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(1), IL3(1), IL5(1)	1379968	6	6	6	4	1	3	2	0	0	0	0.856	1.000	1.000
612	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1)	2521890	5	5	5	3	1	1	0	3	0	0	0.843	1.000	1.000
613	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(1)	959652	4	4	4	3	0	0	4	0	0	0	0.925	1.000	1.000
614	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS3(1)	1392715	2	2	2	2	0	1	1	0	0	0	0.894	1.000	1.000
615	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	779493	2	2	2	3	0	1	1	0	0	0	0.962	1.000	1.000
616	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		328481	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
