rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(120), CAMP(1), CREB3(1), CREB5(7), MAPK1(4), RAF1(7), SNX13(1), SRC(1), TERF2IP(1)	3702957	143	127	39	25	24	4	6	106	3	0	0.00687	6.88e-15	4.24e-12
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(31), CFL1(1), E2F1(4), E2F2(4), MDM2(3), NXT1(1), PRB1(26), TP53(37)	2797685	118	78	92	14	54	3	6	16	39	0	6.01e-09	9.08e-07	0.000280
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(13), CCND1(1), CCNE1(3), CCNE2(12), CDK4(5), CDKN1B(1), CDKN2A(31), E2F1(4), E2F2(4), E2F4(1), PRB1(26)	2981654	101	74	77	14	55	0	4	18	24	0	1.46e-06	0.00935	1.000
4	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(9)	237556	9	9	9	1	6	1	1	1	0	0	0.0730	0.0403	1.000
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(4), SP1(3), TP53(37), WT1(4)	2347608	49	41	43	7	22	1	7	5	14	0	0.00161	0.229	1.000
6	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(10), CDKN2A(31), E2F1(4), MDM2(3), MYC(4), PIK3CA(6), PIK3R1(3), POLR1A(11), POLR1B(8), RAC1(16), RB1(8), TBX2(6), TP53(37), TWIST1(1)	6692195	148	92	118	20	74	7	6	16	42	3	8.53e-10	0.246	1.000
7	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	170466	3	3	3	1	3	0	0	0	0	0	0.612	0.494	1.000
8	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(4), TAT(12)	871759	19	16	18	4	12	2	2	1	2	0	0.0333	0.530	1.000
9	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(5), DCN(15), FMOD(4), KERA(13), LUM(10)	1162061	47	37	44	14	36	4	3	1	3	0	0.00242	0.659	1.000
10	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(4), FOSB(5), GRIA2(31), JUND(1), PPP1R1B(2)	1208725	43	38	40	14	26	3	2	5	7	0	0.0760	0.683	1.000
11	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(5), SNAP25(5), STX1A(2)	1083206	15	14	13	2	9	1	0	1	4	0	0.0134	0.886	1.000
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(5), ATM(11), BAX(3), BCL2(2), CCND1(1), CCNE1(3), CDK4(5), CDKN1A(4), E2F1(4), MDM2(3), PCNA(2), RB1(8), TIMP3(5), TP53(37)	5953323	93	68	86	16	32	7	8	18	26	2	0.000415	0.914	1.000
13	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(6), HLA-DRA(10), HLA-DRB1(3)	777496	20	18	20	8	15	1	0	3	1	0	0.141	0.958	1.000
14	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(1), ALDOB(9), ALDOC(3)	1307091	16	14	13	4	11	2	0	1	2	0	0.0607	0.965	1.000
15	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(2)	512888	2	2	2	0	0	1	0	1	0	0	0.634	0.970	1.000
16	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(1), SLPI(5)	569288	9	9	9	4	4	1	0	4	0	0	0.617	0.973	1.000
17	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3)	548910	3	3	2	1	2	0	0	1	0	0	0.552	0.978	1.000
18	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(7), NFKBIA(2), PLCB1(45), PRKCA(10), RELA(4)	2706318	72	53	68	21	55	3	2	7	5	0	0.00978	0.989	1.000
19	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(1), EIF2S1(1), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TP53(37)	3201987	57	49	51	12	25	4	5	8	15	0	0.00988	0.990	1.000
20	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(4), CD3G(1)	371843	5	5	5	4	4	0	0	0	1	0	0.819	0.991	1.000
21	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(6), SEC61A2(7), SRP19(5), SRP54(3), SRP68(6), SRP72(1), SRP9(1), SRPR(2)	2534869	31	27	28	6	12	0	3	10	6	0	0.149	0.991	1.000
22	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(2), MMP2(6), MMP9(4), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6)	2455694	39	34	39	9	22	2	2	10	3	0	0.0202	0.993	1.000
23	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(14)	604439	16	11	15	8	11	2	1	2	0	0	0.481	0.994	1.000
24	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), RAC1(16), WASF1(3), WASL(5)	2689354	38	35	30	8	26	2	1	5	4	0	0.0211	0.995	1.000
25	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(21), CD34(4), CD3D(4), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(3), IL3(2), IL6(2), IL8(1), KITLG(6)	2027785	53	38	50	17	37	3	2	7	4	0	0.0114	0.997	1.000
26	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(4), DPM2(1), EGR1(4), HRAS(3), KLK2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), NGFR(6), RAF1(7)	2676053	45	40	39	14	22	4	2	10	7	0	0.0378	0.997	1.000
27	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(9), BCMO1(14), RDH5(2)	1292485	28	27	25	10	20	1	1	4	2	0	0.0881	0.999	1.000
28	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(3), NFYC(1), RB1(8), SP1(3)	2207129	16	14	16	4	2	1	2	5	4	2	0.292	0.999	1.000
29	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(1), EHHADH(5), HADHA(8), SDS(2)	1602491	19	18	17	7	11	2	0	5	1	0	0.260	0.999	1.000
30	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), CSF3(3), EPO(5), FLT3(28), IGF1(9), IL1A(4), IL3(2), IL6(2), IL9(1), KITLG(6), TGFB1(1), TGFB3(3)	2720654	65	48	62	22	41	4	4	10	6	0	0.0142	1.000	1.000
31	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(4)	1279473	8	8	8	9	3	0	1	0	4	0	0.985	1.000	1.000
32	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(7), CFL1(1), CFLAR(4), PDE6D(2)	1294332	18	16	18	7	7	1	2	6	2	0	0.599	1.000	1.000
33	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(13), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNH(2), CDC25A(7), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(31), CDKN2C(1), E2F1(4), RB1(8), RBL1(10), TFDP1(2)	5343683	99	70	82	22	45	3	6	15	28	2	0.000222	1.000	1.000
34	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(4), IFNG(1), IFNGR1(4), IFNGR2(4), IKBKB(3), JAK2(7), LIN7A(10), NFKB1(7), NFKBIA(2), RB1(8), RELA(4), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TP53(37), USH1C(15), WT1(4)	5962890	116	76	106	29	50	5	7	19	33	2	0.00203	1.000	1.000
35	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(5), GNAQ(4), ITPKB(5)	1982765	15	15	15	4	10	0	1	1	3	0	0.110	1.000	1.000
36	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASDHPPT(3), AASS(3), KARS(4)	1538751	14	14	14	4	12	0	0	2	0	0	0.307	1.000	1.000
37	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(12), GOT1(3), GOT2(4), TAT(12), TYR(7)	1555309	38	29	37	14	26	4	3	1	4	0	0.0953	1.000	1.000
38	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFV1(2)	2316834	15	15	15	2	11	0	1	3	0	0	0.0744	1.000	1.000
39	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(13), GAD1(12), HDC(16), PNMT(2), TH(7), TPH1(5)	1970359	55	45	52	22	45	2	1	2	5	0	0.0124	1.000	1.000
40	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), IDI1(1), SQLE(3)	1052305	7	7	7	3	3	1	1	2	0	0	0.583	1.000	1.000
41	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(1), EHHADH(5), GCDH(5), HADHA(8), SDHB(1), SDS(2)	2584097	23	20	22	7	15	3	0	4	1	0	0.131	1.000	1.000
42	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(2), IL12B(1), IL18(2), IL2(2)	973416	10	8	10	6	7	1	0	1	1	0	0.620	1.000	1.000
43	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(3), PRKCA(10), TGM2(5)	1644743	20	16	19	9	15	2	0	0	3	0	0.0967	1.000	1.000
44	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(5), ACADS(4), ECHS1(1), HADHA(8)	1818817	22	20	22	7	13	2	1	6	0	0	0.313	1.000	1.000
45	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), FPGS(2), GGH(2), SPR(2)	2102059	38	29	35	14	30	4	2	1	1	0	0.0169	1.000	1.000
46	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(7), CSF2(1), CSF3(3), EPO(5), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL7(5), IL8(1), IL9(1)	1996913	40	33	40	18	28	2	1	4	5	0	0.0641	1.000	1.000
47	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(2), CBS(6), CTH(1), MUT(5)	1685619	16	16	16	6	10	2	1	2	1	0	0.356	1.000	1.000
48	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(4), B3GNT1(2), FUT1(3), FUT2(3), FUT9(22), ST8SIA1(1)	1977279	35	33	34	15	25	3	2	5	0	0	0.125	1.000	1.000
49	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(5)	1024876	8	8	8	8	5	0	1	1	1	0	0.909	1.000	1.000
50	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(6), CD80(4), HLA-DRA(10), HLA-DRB1(3), IL10(3), IL2(2), IL4(1)	1302146	30	25	30	13	19	1	1	6	3	0	0.147	1.000	1.000
51	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(10), LPL(3), NR3C1(6), PPARG(11), RETN(2), RXRA(4), TNF(1)	1928268	37	31	35	14	24	2	0	6	5	0	0.118	1.000	1.000
52	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5)	1866390	97	69	81	31	74	7	5	9	2	0	0.00599	1.000	1.000
53	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(11), CDC25A(7), CDC25B(4), CDC25C(2), CDK4(5), CHEK1(1), MYT1(19), RB1(8), TP53(37), WEE1(2)	5811609	96	69	88	23	43	5	6	15	25	2	0.00663	1.000	1.000
54	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(3), OXCT1(4)	1113816	8	8	8	5	5	1	0	1	1	0	0.790	1.000	1.000
55	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(4), ENO3(4), FARS2(4), GOT1(3), GOT2(4), PAH(9), TAT(12), YARS(1)	2762388	44	38	41	16	31	5	2	3	3	0	0.0281	1.000	1.000
56	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(11), IARS(8), LARS(9), LARS2(2), PDHA1(2), PDHA2(15), PDHB(1)	3332887	48	37	44	12	33	4	1	5	5	0	0.0316	1.000	1.000
57	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(1), GLUD2(3)	1503251	7	7	7	7	2	1	1	1	2	0	0.958	1.000	1.000
58	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSS(7), IL8(1), NFKB1(7), NOX1(10), RELA(4), TNF(1), XDH(44)	3259211	76	56	73	29	57	5	4	7	3	0	0.0129	1.000	1.000
59	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(2), DFFB(3), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(8), TOP2B(7)	2962606	30	24	30	9	18	1	4	5	2	0	0.292	1.000	1.000
60	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(4), BRAF(120), CREB3(1), CREB5(7), DUSP6(1), DUSP9(3), EEF2K(5), GRB2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(3), MKNK2(1), MOS(3), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), SHC1(1), SOS1(7), SOS2(11), TRAF3(5)	9703364	215	151	104	58	73	7	9	118	8	0	0.0212	1.000	1.000
61	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(4), CD3G(1), CD4(6), FYN(5), HLA-DRA(10), HLA-DRB1(3), LCK(10), PTPRC(26), ZAP70(4)	2912348	69	52	66	27	45	7	1	9	7	0	0.0806	1.000	1.000
62	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(8), CSF2(1), HLA-DRA(10), HLA-DRB1(3), IL3(2), IL5(2)	1001088	27	25	27	15	22	0	0	3	2	0	0.209	1.000	1.000
63	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1)	1394598	10	9	10	5	7	1	1	1	0	0	0.549	1.000	1.000
64	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(6), FARSB(5), GOT1(3), GOT2(4), PAH(9), TAT(12), YARS(1), YARS2(2)	2882096	46	38	43	17	31	6	2	2	5	0	0.0420	1.000	1.000
65	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), NFS1(1), TPK1(9)	2115929	18	17	17	7	12	1	1	2	1	1	0.523	1.000	1.000
66	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(1), EHHADH(5), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT5(5), SIRT7(2), VNN2(13)	3917038	46	39	44	12	27	5	3	9	2	0	0.0358	1.000	1.000
67	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(2), ACP5(3), ACPP(6), ENPP1(10), ENPP3(14), FLAD1(7), TYR(7)	3193471	52	40	50	15	32	5	2	5	8	0	0.0408	1.000	1.000
68	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(3), CUL1(5), E2F1(4), FBXW7(10), RB1(8), TFDP1(2)	2689836	35	29	35	11	13	2	5	6	7	2	0.177	1.000	1.000
69	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(5), AASDHPPT(3), AASS(3), KARS(4)	2282739	19	17	19	6	16	0	0	2	1	0	0.327	1.000	1.000
70	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(5), BAX(3), BCL10(2), BCL2(2), BCL2L11(5), CASP8AP2(7), CASP9(2), CES1(16)	3567068	42	32	40	12	25	6	2	3	6	0	0.102	1.000	1.000
71	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(6), CASP8(7), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1)	2705266	24	24	24	9	16	0	2	3	3	0	0.283	1.000	1.000
72	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5)	2920311	27	21	27	9	14	2	2	6	3	0	0.342	1.000	1.000
73	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(17), DAXX(8), HRAS(3), PAX3(3), PML(3), RARA(3), RB1(8), SP100(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TP53(37)	6204076	95	65	89	25	40	6	10	15	22	2	0.00889	1.000	1.000
74	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(1), GOT1(3), GOT2(4), LDHA(4), LDHB(2), LDHC(5), MPST(2)	2272151	30	25	28	11	21	1	5	2	1	0	0.150	1.000	1.000
75	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(13), CCNE1(3), CDC34(3), CUL1(5), E2F1(4), RB1(8), SKP2(2), TFDP1(2)	2813688	40	33	40	13	21	2	4	6	5	2	0.0968	1.000	1.000
76	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(1), ALAS2(5), CPOX(2), FECH(3), HMBS(1), PPOX(2), UROS(1)	2502665	19	19	19	8	13	1	1	1	3	0	0.333	1.000	1.000
77	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(7), CDC25B(4), CDKN1A(4), CHEK1(1), NEK1(6), WEE1(2)	2294556	24	21	24	7	11	5	1	4	3	0	0.299	1.000	1.000
78	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), ME1(17), PC(12), PDHA1(2), SLC25A11(1)	3081479	44	32	43	17	26	4	2	9	3	0	0.0808	1.000	1.000
79	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(6), ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), CMBL(3), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), PON1(10), PON3(1)	5923184	141	81	135	42	102	10	6	10	13	0	8.95e-06	1.000	1.000
80	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(1), HRAS(3), MAP2K1(11), MAP2K2(3), NGFR(6), NTRK1(12), PIK3CA(6), PIK3CD(7), SHC1(1), SOS1(7)	5258584	78	57	72	24	34	13	2	19	10	0	0.0499	1.000	1.000
81	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(3), BMPR2(4)	2077994	13	13	13	7	5	3	0	3	2	0	0.697	1.000	1.000
82	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(17), DFFA(2), DFFB(3), GZMA(10), GZMB(2), HMGB2(1), PRF1(7), SET(1)	3505672	45	34	43	13	23	3	5	10	4	0	0.119	1.000	1.000
83	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(4), FH(3), IDH1(11), IDH2(2), MDH1(1), MDH2(3), SDHB(1)	2968905	30	23	21	11	22	0	2	3	3	0	0.135	1.000	1.000
84	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(1), GPD2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), UQCRC1(3)	2200969	11	11	11	5	7	0	1	1	2	0	0.554	1.000	1.000
85	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(7), SNCA(2), SNCAIP(41), UBE2E2(2), UBE2F(3), UBE2G2(1), UBE2L6(2)	2127995	65	53	58	26	47	8	1	4	5	0	0.136	1.000	1.000
86	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(10), NR0B2(3), NR1H3(2), NR1H4(11), RXRA(4)	1797620	30	25	30	14	17	6	3	2	2	0	0.176	1.000	1.000
87	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(45), NRG2(5), NRG3(18), PRKCA(10), PSEN1(1)	2942174	80	60	73	29	61	4	2	5	8	0	0.0492	1.000	1.000
88	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(6), ENPP1(10), ENPP3(14), FLAD1(7), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), TYR(7)	4953964	71	49	68	18	44	6	5	7	9	0	0.00766	1.000	1.000
89	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(8), CD4(6), HLA-DRA(10), HLA-DRB1(3), IL1B(6), IL4(1), IL5(2), IL5RA(11), IL6(2)	1763611	50	44	48	25	37	1	1	5	6	0	0.0963	1.000	1.000
90	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADHA(8), HADHB(3), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(3), PPT2(8)	2807646	37	36	35	14	14	4	4	12	3	0	0.402	1.000	1.000
91	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(5), SULT1A2(2), SULT1E1(10), SULT2A1(6), SUOX(3)	2016956	28	18	27	11	21	1	0	2	4	0	0.242	1.000	1.000
92	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(2), CDO1(5), CTH(1), GOT1(3), GOT2(4), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(10), SULT1C2(5), SULT1C4(9), SULT4A1(6)	4152462	80	58	76	27	53	2	9	7	9	0	0.0143	1.000	1.000
93	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	1876930	15	15	15	9	10	2	1	2	0	0	0.550	1.000	1.000
94	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(5), FUT1(3), FUT2(3), FUT9(22), GBGT1(1), GLA(1), HEXA(4), HEXB(3), NAGA(3), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	3338141	53	39	52	24	33	6	1	9	4	0	0.146	1.000	1.000
95	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(11), COASY(3), DPYD(53), DPYS(21), ENPP1(10), ENPP3(14), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(1), UPB1(6)	4590606	133	78	119	38	93	9	4	17	10	0	0.000894	1.000	1.000
96	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(1), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(10)	2923150	30	25	29	11	19	2	0	4	5	0	0.238	1.000	1.000
97	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(10), ATM(11), ATR(18), CCNA1(13), CCND1(1), CCNE1(3), CDC25A(7), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(31), E2F1(4), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(2), TGFB1(1), TGFB3(3), TP53(37)	9961073	166	104	143	39	75	7	12	21	49	2	6.46e-05	1.000	1.000
98	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(23), PIK3CA(6), PIK3R1(3), RAC1(16), WASL(5)	4443435	69	51	61	21	45	3	2	10	8	1	0.0746	1.000	1.000
99	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2)	4416670	39	34	38	11	23	3	2	6	5	0	0.0342	1.000	1.000
100	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(11), ATR(18), CDC25C(2), CHEK1(1), CHEK2(2), TP53(37)	5286366	71	56	65	19	35	2	6	9	19	0	0.0880	1.000	1.000
101	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(13), CHKA(2), PCYT1A(3), PDHA1(2), PDHA2(15), PEMT(2), SLC18A3(2)	2263430	42	35	39	20	33	5	0	1	3	0	0.122	1.000	1.000
102	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(1), IFRD1(2), IL18(2), IL1A(4), IL1R1(10), JUND(1), MYOG(2), NR4A3(6), WDR1(3)	3510892	44	36	43	16	26	5	2	4	7	0	0.194	1.000	1.000
103	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(5), CD3D(4), CD3G(1), GZMB(2), HLA-A(3), ICAM1(1), ITGAL(19), ITGB2(10), PRF1(7)	2870108	52	42	51	25	28	6	1	5	12	0	0.258	1.000	1.000
104	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(5), BAX(3), BCL2(2), BIK(2), BIRC2(3), BIRC3(6), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), DFFA(2), DFFB(3), DIABLO(1)	4461920	43	36	43	14	22	4	6	6	5	0	0.239	1.000	1.000
105	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(11), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(3), FASN(15), HADHA(8), HSD17B12(2), PECR(1), SCD(3)	4717329	60	48	60	22	38	4	2	9	7	0	0.0148	1.000	1.000
106	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDKN1B(1), CUL1(5), E2F1(4), NEDD8(1), RB1(8), SKP2(2), TFDP1(2), UBE2M(1)	2840634	27	26	27	11	9	2	4	4	6	2	0.366	1.000	1.000
107	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(1), ITGAL(19), ITGAM(17), ITGB2(10), SELE(28), SELL(7)	3385085	87	58	87	32	60	4	3	7	13	0	0.0139	1.000	1.000
108	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(4), CBS(6), CTH(1), DNMT1(16), DNMT3A(5), DNMT3B(8), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), MTR(7)	5836254	66	48	65	23	39	4	7	9	7	0	0.0384	1.000	1.000
109	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(7), FDPS(3), HMGCR(11), HMGCS1(1), IDI1(1), MVD(1), MVK(2), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(2), SQLE(3)	4350726	38	34	36	15	14	6	2	10	6	0	0.373	1.000	1.000
110	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(1), ITGA4(29), ITGAL(19), ITGAM(17), ITGB1(4), ITGB2(10), SELE(28), SELL(7), SELP(28)	5200616	148	83	141	45	109	4	4	13	18	0	0.000614	1.000	1.000
111	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(11), BCAT2(1), COASY(3), DPYD(53), DPYS(21), ENPP1(10), ENPP3(14), ILVBL(3), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(1), UPB1(6), VNN1(7)	5696693	144	80	130	43	102	9	4	18	11	0	0.000335	1.000	1.000
112	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(7), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(4), ATF4(7), BDNF(3), BRAF(120), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1F(18), CACNA1G(26), CACNA1H(21), CACNA1I(27), CACNA1S(41), CACNA2D1(9), CACNA2D2(12), CACNA2D3(41), CACNA2D4(14), CACNB1(4), CACNB2(12), CACNB3(2), CACNB4(9), CACNG1(3), CACNG2(9), CACNG3(17), CACNG4(2), CACNG5(7), CACNG6(5), CACNG7(4), CACNG8(1), CASP3(2), CD14(4), CDC25B(4), CDC42(2), CHP(3), CHUK(2), CRK(2), CRKL(2), DAXX(8), DDIT3(2), DUSP10(5), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(14), EGFR(17), ELK1(2), ELK4(6), FAS(5), FASLG(12), FGF1(1), FGF10(2), FGF11(2), FGF12(9), FGF13(6), FGF14(4), FGF16(7), FGF17(1), FGF18(2), FGF19(2), FGF2(2), FGF21(3), FGF23(8), FGF3(3), FGF4(2), FGF5(5), FGF6(4), FGF7(6), FGF8(1), FGF9(4), FGFR1(11), FGFR2(26), FGFR3(7), FGFR4(7), FLNA(14), FLNB(29), FLNC(47), FOS(2), GADD45B(2), GNA12(3), GRB2(1), HRAS(3), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), JUN(1), JUND(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K6(4), MAP3K7(1), MAP4K1(8), MAP4K2(4), MAP4K3(7), MAP4K4(6), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MAPT(9), MEF2C(2), MKNK1(3), MKNK2(1), MOS(3), MRAS(1), MYC(4), NF1(38), NFATC2(6), NFATC4(11), NFKB1(7), NFKB2(4), NLK(5), NR4A1(2), NRAS(65), NTF3(4), NTRK1(12), NTRK2(8), PAK1(4), PAK2(8), PDGFA(1), PDGFB(2), PDGFRA(23), PDGFRB(11), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PPM1A(3), PPM1B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PPP5C(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PTPN5(10), PTPN7(1), PTPRR(16), RAC1(16), RAC2(1), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF2(7), RASA1(4), RASA2(12), RASGRF1(15), RASGRF2(17), RASGRP1(6), RASGRP2(6), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(3), RPS6KA6(15), RRAS(1), SOS1(7), SOS2(11), SRF(3), STK4(1), STMN1(3), TAOK1(10), TAOK2(22), TAOK3(3), TGFB1(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF1A(2), TP53(37), TRAF2(1), TRAF6(4), ZAK(6)	92956655	1841	215	1611	933	1077	150	90	339	181	4	0.0131	1.000	1.000
113	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(10), BCAR1(4), BCL2(2), BIRC2(3), BIRC3(6), BRAF(120), CAPN2(7), CAV1(1), CCND1(1), CCND2(3), CCND3(2), CDC42(2), CHAD(3), COL11A1(49), COL11A2(27), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), COMP(4), CRK(2), CRKL(2), CTNNB1(11), DIAPH1(6), DOCK1(12), EGF(14), EGFR(17), ELK1(2), ERBB2(7), FARP2(5), FIGF(3), FLNA(14), FLNB(29), FLNC(47), FLT1(28), FN1(20), FYN(5), GRB2(1), GRLF1(10), GSK3B(2), HGF(22), HRAS(3), IBSP(7), IGF1(9), IGF1R(9), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAV(9), ITGB1(4), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), JUN(1), KDR(32), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), MAP2K1(11), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MET(19), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLK(35), MYLK2(9), MYLPF(1), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PARVB(3), PARVG(3), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(6), PDGFRA(23), PDGFRB(11), PDPK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP5K1C(6), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PRKCA(10), PRKCG(13), PTEN(18), PTK2(8), PXN(3), RAC1(16), RAC2(1), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF1(9), RELN(58), RHOA(1), ROCK1(4), ROCK2(13), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SPP1(6), SRC(1), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TLN1(11), TLN2(21), TNC(27), TNN(39), TNR(61), TNXB(115), VASP(3), VAV1(13), VAV2(2), VAV3(8), VCL(7), VEGFA(5), VEGFB(1), VEGFC(17), VTN(7), VWF(40), ZYX(6)	122249312	2671	212	2464	1083	1794	177	84	380	233	3	1.44e-09	1.000	1.000
114	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), APC(17), APC2(8), ARAF(3), ARHGEF1(1), ARHGEF12(10), ARHGEF4(4), ARHGEF6(10), ARHGEF7(3), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(4), BDKRB1(3), BDKRB2(9), BRAF(120), CD14(4), CDC42(2), CFL1(1), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CRK(2), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(19), DIAPH1(6), DIAPH2(6), DIAPH3(10), DOCK1(12), EGF(14), EGFR(17), EZR(1), F2(9), F2R(5), FGD1(3), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(9), FGF13(6), FGF14(4), FGF16(7), FGF17(1), FGF18(2), FGF19(2), FGF2(2), FGF21(3), FGF23(8), FGF3(3), FGF4(2), FGF5(5), FGF6(4), FGF7(6), FGF8(1), FGF9(4), FGFR1(11), FGFR2(26), FGFR3(7), FGFR4(7), FN1(20), GIT1(3), GNA12(3), GNA13(1), GRLF1(10), GSN(3), HRAS(3), IQGAP1(8), IQGAP2(17), IQGAP3(11), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAD(17), ITGAE(12), ITGAL(19), ITGAM(17), ITGAV(9), ITGAX(15), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), KRAS(4), LIMK1(2), LIMK2(9), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MOS(3), MRAS(1), MSN(1), MYH10(13), MYH14(13), MYH9(11), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLK(35), MYLK2(9), MYLPF(1), NCKAP1(5), NCKAP1L(20), NRAS(65), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDGFA(1), PDGFB(2), PDGFRA(23), PDGFRB(11), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PPP1R12B(7), PTK2(8), PXN(3), RAC1(16), RAC2(1), RAF1(7), RDX(1), RHOA(1), ROCK1(4), ROCK2(13), RRAS(1), SCIN(6), SLC9A1(3), SOS1(7), SOS2(11), SSH1(13), SSH2(7), SSH3(3), TIAM1(17), TIAM2(20), TMSL3(1), VAV1(13), VAV2(2), VAV3(8), VCL(7), WAS(6), WASF1(3), WASF2(3), WASL(5)	90542954	1588	212	1377	710	915	96	80	348	146	3	5.46e-05	1.000	1.000
115	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(120), C7orf16(1), CACNA1A(25), CRH(3), CRHR1(6), GNA11(6), GNA12(3), GNA13(1), GNAI1(1), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(17), GNAZ(5), GRIA1(33), GRIA2(31), GRIA3(19), GRID2(44), GRM1(14), GRM5(10), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), HRAS(3), IGF1(9), IGF1R(9), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), LYN(5), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), NOS1(48), NOS3(14), NPR1(11), NPR2(9), NRAS(65), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PRKCA(10), PRKCG(13), PRKG1(10), PRKG2(13), RAF1(7), RYR1(72)	35975990	986	208	771	451	578	54	53	232	68	1	0.000216	1.000	1.000
116	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(15), ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), ADRA1A(7), ADRA1B(2), ADRA2A(1), ADRA2B(8), ADRA2C(1), ADRB1(4), ADRB2(2), AGTR1(9), AGTR2(10), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), C5AR1(9), CALCR(14), CALCRL(11), CCKAR(9), CCKBR(8), CGA(1), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CNR1(7), CNR2(4), CRHR1(6), CRHR2(2), CTSG(2), CYSLTR1(4), CYSLTR2(1), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), EDNRA(8), EDNRB(4), F2(9), F2R(5), F2RL1(14), F2RL2(5), F2RL3(3), FPR1(15), FSHB(4), FSHR(13), GABBR1(6), GABBR2(9), GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GABRB1(14), GABRB2(17), GABRB3(15), GABRD(3), GABRE(18), GABRG1(28), GABRG2(13), GABRG3(6), GABRP(8), GABRQ(8), GABRR1(6), GABRR2(1), GALR1(4), GALR3(2), GH1(3), GH2(9), GHR(20), GHRHR(3), GHSR(4), GIPR(1), GLP1R(11), GLP2R(13), GLRA1(11), GLRA2(5), GLRA3(11), GLRB(24), GNRHR(1), GPR156(9), GPR35(1), GPR50(16), GPR63(6), GPR83(9), GRIA1(33), GRIA2(31), GRIA3(19), GRIA4(19), GRID1(18), GRID2(44), GRIK1(18), GRIK2(15), GRIK3(24), GRIK4(10), GRIK5(8), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), GRIN3A(30), GRIN3B(4), GRM1(14), GRM2(5), GRM3(45), GRM4(14), GRM5(10), GRM6(21), GRM7(28), GRM8(41), GRPR(4), GZMA(10), HCRTR1(2), HCRTR2(24), HRH1(9), HRH2(2), HRH3(3), HRH4(5), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), LEP(2), LEPR(19), LHCGR(21), LTB4R(1), LTB4R2(1), MAS1(3), MC2R(5), MC3R(6), MC4R(1), MC5R(7), MCHR1(1), MCHR2(14), MTNR1A(7), MTNR1B(5), NMBR(6), NMUR1(5), NMUR2(12), NPBWR1(1), NPBWR2(9), NPFFR1(1), NPFFR2(9), NPY1R(23), NPY2R(11), NPY5R(20), NR3C1(6), NTSR1(5), NTSR2(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(7), P2RX4(2), P2RX5(6), P2RX7(4), P2RY1(4), P2RY10(6), P2RY13(4), P2RY14(5), P2RY2(7), P2RY6(1), P2RY8(4), PARD3(14), PPYR1(10), PRL(1), PRLHR(1), PRLR(24), PRSS1(23), PRSS3(3), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(2), PTGFR(18), PTGIR(3), PTH2R(13), RXFP1(12), RXFP2(20), SCTR(6), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), SSTR5(3), TAAR1(2), TAAR2(8), TAAR5(3), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(6), TACR2(6), TACR3(21), TBXA2R(4), THRA(2), THRB(12), TRHR(17), TRPV1(2), TSHB(5), TSHR(6), UTS2R(1), VIPR1(2), VIPR2(5)	72360958	2077	206	1920	1264	1448	168	75	211	173	2	5.01e-08	1.000	1.000
117	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(3), BRAF(120), CASP3(2), CD244(6), CD247(2), CD48(3), CHP(3), CSF2(1), FAS(5), FASLG(12), FCGR3A(6), FCGR3B(2), FYN(5), GRB2(1), GZMB(2), HLA-A(3), HLA-B(4), HLA-C(1), HLA-E(1), HLA-G(2), HRAS(3), ICAM1(1), ICAM2(3), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), ITGAL(19), ITGB2(10), KIR2DL1(17), KIR2DL3(6), KIR2DL4(3), KIR3DL1(12), KIR3DL2(2), KLRC1(3), KLRC2(1), KLRC3(11), KLRD1(3), KLRK1(5), KRAS(4), LAT(1), LCK(10), LCP2(9), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MICA(3), MICB(1), NCR1(12), NCR2(11), NCR3(2), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NRAS(65), PAK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRF1(7), PRKCA(10), PRKCG(13), PTK2B(8), PTPN11(9), PTPN6(2), RAC1(16), RAC2(1), RAF1(7), SH2D1A(2), SH2D1B(2), SH3BP2(2), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SYK(12), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFSF10(7), TYROBP(5), ULBP1(2), ULBP3(5), VAV1(13), VAV2(2), VAV3(8), ZAP70(4)	37146848	834	206	640	313	435	45	53	243	57	1	9.63e-05	1.000	1.000
118	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(24), ADCY8(40), ARAF(3), ATF4(7), BRAF(120), CACNA1C(32), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CHP(3), CREBBP(17), EP300(13), GNAQ(4), GRIA1(33), GRIA2(31), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), GRM1(14), GRM5(10), HRAS(3), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), NRAS(65), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PPP1R1A(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF3(10), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15)	32397689	877	203	671	408	483	57	55	227	54	1	0.00617	1.000	1.000
119	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(18), ACACB(15), AKT1(3), AKT2(8), AKT3(4), ARAF(3), BRAF(120), CALM1(1), CALM2(1), CALML3(5), CBL(8), CBLB(14), CBLC(10), CRK(2), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(15), FBP1(2), FBP2(2), FLOT1(2), FOXO1(5), G6PC(4), G6PC2(3), GCK(15), GRB2(1), GSK3B(2), GYS1(3), GYS2(13), HRAS(3), IKBKB(3), INPP5D(24), INSR(19), IRS1(5), IRS2(2), IRS4(9), KRAS(4), LIPE(8), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MKNK1(3), MKNK2(1), NRAS(65), PCK1(16), PCK2(4), PDE3A(17), PDE3B(6), PDPK1(4), PFKL(4), PFKM(1), PHKA1(17), PHKA2(7), PHKB(6), PHKG1(1), PHKG2(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PKLR(8), PKM2(3), PPARGC1A(12), PPP1CB(5), PPP1CC(2), PPP1R3A(45), PPP1R3B(5), PPP1R3C(2), PPP1R3D(3), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKACA(3), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCI(7), PRKCZ(4), PRKX(3), PTPN1(4), PTPRF(25), PYGB(2), PYGL(6), PYGM(9), RAF1(7), RAPGEF1(9), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SLC2A4(7), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(10), SOS1(7), SOS2(11), SREBF1(5), TRIP10(4), TSC1(5), TSC2(11)	52634011	953	203	767	354	502	60	63	253	73	2	3.43e-06	1.000	1.000
120	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(6), ACTG1(6), CHAD(3), COL11A1(49), COL11A2(27), COL17A1(25), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), COMP(4), DES(7), DSC1(36), DSC2(28), DSC3(34), DSG1(50), DSG2(17), DSG3(56), DSG4(45), FN1(20), GJA1(6), GJA10(12), GJA4(4), GJA5(6), GJA8(17), GJA9(2), GJB1(1), GJB2(1), GJB3(3), GJB4(4), GJB5(5), GJB6(5), GJB7(1), GJC1(6), GJD2(5), IBSP(7), INA(3), ITGA6(6), ITGB4(20), KRT1(16), KRT10(14), KRT12(10), KRT13(10), KRT14(2), KRT15(10), KRT16(10), KRT17(7), KRT18(2), KRT2(14), KRT20(7), KRT23(7), KRT24(7), KRT25(10), KRT27(4), KRT28(10), KRT3(12), KRT31(8), KRT32(9), KRT33A(5), KRT33B(2), KRT34(9), KRT35(8), KRT36(14), KRT37(10), KRT38(7), KRT39(9), KRT4(14), KRT40(6), KRT5(14), KRT6A(13), KRT6B(8), KRT6C(12), KRT7(5), KRT71(14), KRT72(11), KRT73(10), KRT74(11), KRT75(11), KRT76(10), KRT77(11), KRT78(17), KRT79(6), KRT8(5), KRT81(2), KRT82(6), KRT83(12), KRT84(10), KRT85(7), KRT86(3), KRT9(16), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), LMNA(8), LMNB1(2), LMNB2(4), NES(16), PRPH(1), RELN(58), SPP1(6), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNC(27), TNN(39), TNR(61), TNXB(115), VIM(5), VTN(7), VWF(40)	82294482	2274	201	2179	957	1678	168	60	195	172	1	1.99e-09	1.000	1.000
121	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(10), ABL2(10), AKT1(3), AKT2(8), AKT3(4), ARAF(3), AREG(4), BRAF(120), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CBL(8), CBLB(14), CBLC(10), CDKN1A(4), CDKN1B(1), CRK(2), CRKL(2), EGF(14), EGFR(17), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(4), ERBB4(45), EREG(4), GAB1(2), GRB2(1), GSK3B(2), HBEGF(1), HRAS(3), JUN(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MYC(4), NCK1(1), NCK2(4), NRAS(65), NRG1(15), NRG2(5), NRG3(18), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PRKCA(10), PRKCG(13), PTK2(8), RAF1(7), RPS6KB1(2), RPS6KB2(2), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SRC(1), STAT5A(2), STAT5B(4), TGFA(2)	33789028	743	201	554	240	361	43	54	233	51	1	2.49e-06	1.000	1.000
122	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(2), ACVR2A(4), ACVR2B(3), AMHR2(14), BMP2(3), BMP7(1), BMPR1A(1), BMPR1B(3), BMPR2(4), CCL1(1), CCL11(1), CCL14(2), CCL15(2), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL24(3), CCL26(1), CCL27(2), CCL7(4), CCL8(2), CCR1(7), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CD27(2), CD40(4), CD40LG(1), CNTF(1), CSF1(7), CSF1R(10), CSF2(1), CSF2RA(17), CSF2RB(14), CSF3(3), CSF3R(2), CX3CL1(4), CX3CR1(11), CXCL10(2), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(1), CXCR3(3), CXCR4(3), CXCR6(4), EDA(2), EDA2R(3), EDAR(5), EGF(14), EGFR(17), EPO(5), EPOR(1), FAS(5), FASLG(12), FLT1(28), FLT3(28), FLT3LG(2), FLT4(17), GDF5(11), GH1(3), GH2(9), GHR(20), HGF(22), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(4), IL10(3), IL10RA(6), IL10RB(5), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL13RA1(3), IL15(3), IL15RA(5), IL17A(8), IL17B(3), IL17RA(3), IL17RB(2), IL18(2), IL18R1(16), IL18RAP(18), IL19(2), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), IL1RAP(4), IL2(2), IL20(4), IL20RA(9), IL21(6), IL21R(15), IL22(1), IL22RA1(8), IL23A(1), IL23R(7), IL25(2), IL26(2), IL28B(3), IL28RA(3), IL29(1), IL2RA(3), IL2RB(7), IL2RG(2), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(24), IL8(1), IL9(1), IL9R(4), INHBA(12), INHBB(4), INHBC(10), INHBE(3), KDR(32), KIT(8), KITLG(6), LEP(2), LEPR(19), LIF(2), LIFR(28), LTA(1), LTB(2), MET(19), MPL(7), NGFR(6), OSM(5), OSMR(34), PDGFB(2), PDGFC(14), PDGFRA(23), PDGFRB(11), PLEKHO2(4), PPBP(4), PRL(1), PRLR(24), RELT(2), TGFB1(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFRSF11A(3), TNFRSF11B(8), TNFRSF12A(1), TNFRSF13B(6), TNFRSF14(2), TNFRSF17(5), TNFRSF18(2), TNFRSF19(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(8), TNFRSF25(4), TNFRSF4(2), TNFRSF6B(2), TNFRSF8(16), TNFRSF9(3), TNFSF10(7), TNFSF11(3), TNFSF12(1), TNFSF13B(1), TNFSF14(7), TNFSF15(4), TNFSF18(6), TNFSF4(2), TNFSF8(3), TNFSF9(1), TPO(33), TSLP(1), VEGFA(5), VEGFB(1), VEGFC(17), XCL1(1), XCL2(1), XCR1(4)	58179233	1250	199	1210	677	868	86	38	128	130	0	0.0536	1.000	1.000
123	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(13), CD36(4), CD44(5), CD47(1), CHAD(3), COL11A1(49), COL11A2(27), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), DAG1(5), FN1(20), FNDC1(28), FNDC3A(7), FNDC4(3), FNDC5(3), GP5(3), GP6(4), GP9(4), HMMR(4), HSPG2(23), IBSP(7), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAV(9), ITGB1(4), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), RELN(58), SDC1(3), SDC2(2), SDC3(5), SDC4(2), SPP1(6), SV2A(12), SV2B(25), SV2C(13), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNC(27), TNN(39), TNR(61), TNXB(115), VTN(7), VWF(40)	73862106	1755	199	1695	729	1284	102	57	160	151	1	0.000326	1.000	1.000
124	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY7(9), ADCY8(40), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRB1(4), ADRB2(2), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(13), ATP2B1(6), ATP2B2(22), ATP2B3(7), ATP2B4(11), AVPR1A(3), AVPR1B(6), BDKRB1(3), BDKRB2(9), BST1(1), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1F(18), CACNA1G(26), CACNA1H(21), CACNA1I(27), CACNA1S(41), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CCKAR(9), CCKBR(8), CD38(2), CHP(3), CHRM1(3), CHRM2(17), CHRM3(17), CHRM5(4), CHRNA7(2), CYSLTR1(4), CYSLTR2(1), DRD1(6), EDNRA(8), EDNRB(4), EGFR(17), ERBB2(7), ERBB3(4), ERBB4(45), F2R(5), GNA11(6), GNA14(4), GNA15(5), GNAL(2), GNAQ(4), GNAS(17), GRIN1(5), GRIN2A(74), GRIN2C(4), GRIN2D(6), GRM1(14), GRM5(10), GRPR(4), HRH1(9), HRH2(2), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), LHCGR(21), LTB4R2(1), MYLK(35), MYLK2(9), NOS1(48), NOS3(14), NTSR1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(7), P2RX4(2), P2RX5(6), P2RX7(4), PDE1A(32), PDE1B(10), PDE1C(37), PDGFRA(23), PDGFRB(11), PHKA1(17), PHKA2(7), PHKB(6), PHKG1(1), PHKG2(2), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(18), PTK2B(8), RYR1(72), RYR2(77), RYR3(66), SLC25A6(2), SLC8A1(26), SLC8A2(7), SLC8A3(26), SPHK1(1), SPHK2(6), TACR1(6), TACR2(6), TACR3(21), TBXA2R(4), TNNC1(2), TNNC2(4), TRHR(17), TRPC1(5), VDAC1(1), VDAC2(1), VDAC3(1)	87615778	1963	197	1863	1250	1389	143	72	184	173	2	0.0109	1.000	1.000
125	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(10), ABLIM1(9), ABLIM2(5), ABLIM3(6), ARHGEF12(10), CDC42(2), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(3), DCC(71), DPYSL2(3), DPYSL5(7), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(2), EPHA1(12), EPHA2(12), EPHA3(24), EPHA4(16), EPHA5(6), EPHA6(58), EPHA7(36), EPHA8(13), EPHB1(22), EPHB2(21), EPHB3(12), EPHB4(10), EPHB6(19), FES(4), FYN(5), GNAI1(1), GNAI2(4), GNAI3(2), GSK3B(2), HRAS(3), ITGB1(4), KRAS(4), L1CAM(8), LIMK1(2), LIMK2(9), LRRC4C(37), MAPK1(4), MAPK3(1), MET(19), NCK1(1), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NGEF(12), NRAS(65), NRP1(16), NTN4(13), NTNG1(13), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PLXNA1(13), PLXNA2(5), PLXNA3(9), PLXNB1(16), PLXNB2(16), PLXNB3(5), PLXNC1(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PTK2(8), RAC1(16), RAC2(1), RASA1(4), RGS3(9), RHOA(1), RHOD(1), RND1(6), ROBO1(21), ROBO2(31), ROBO3(12), ROCK1(4), ROCK2(13), SEMA3A(8), SEMA3B(2), SEMA3C(3), SEMA3D(10), SEMA3E(19), SEMA3F(9), SEMA3G(11), SEMA4A(7), SEMA4B(3), SEMA4C(5), SEMA4D(7), SEMA4F(6), SEMA4G(7), SEMA5A(16), SEMA5B(12), SEMA6A(5), SEMA6B(6), SEMA6C(5), SEMA6D(4), SEMA7A(3), SLIT1(14), SLIT2(47), SLIT3(36), SRGAP1(6), SRGAP2(7), SRGAP3(28), UNC5A(6), UNC5B(9), UNC5C(12), UNC5D(20)	64159946	1305	195	1184	633	846	97	59	193	110	0	0.00159	1.000	1.000
126	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(10), ACTN1(5), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(1), ARHGEF6(10), ARHGEF7(3), BCAR1(4), BRAF(120), CAV1(1), CDC42(2), CDKN2A(31), CRK(2), CSE1L(4), DOCK1(12), EPHB2(21), FYN(5), GRB2(1), GRB7(4), GRLF1(10), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MRAS(1), MYLK(35), MYLK2(9), P4HB(2), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PIK3CA(6), PIK3CB(21), PKLR(8), PLCG1(7), PLCG2(22), PTEN(18), PTK2(8), RAF1(7), RALA(1), RHO(1), ROCK1(4), ROCK2(13), SHC1(1), SOS1(7), SOS2(11), SRC(1), TERF2IP(1), TLN1(11), TLN2(21), VASP(3), WAS(6), ZYX(6)	40088224	766	194	620	271	394	49	32	200	91	0	2.83e-06	1.000	1.000
127	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(120), CPEB1(6), EGFR(17), ERBB2(7), ERBB4(45), ETS1(3), ETS2(7), ETV6(10), ETV7(2), FMN2(56), GRB2(1), KRAS(4), MAP2K1(11), MAPK1(4), MAPK3(1), NOTCH1(5), NOTCH2(34), NOTCH3(21), NOTCH4(48), PIWIL1(17), PIWIL2(11), PIWIL3(9), PIWIL4(4), RAF1(7), SOS1(7), SOS2(11), SPIRE1(2), SPIRE2(6)	17301949	476	190	356	141	244	21	19	166	26	0	0.000106	1.000	1.000
128	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(21), CASK(4), CDC42(2), CDK4(5), CGN(7), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(1), CSDA(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTTN(1), EPB41(8), EPB41L1(7), EPB41L2(17), EPB41L3(6), EXOC3(2), EXOC4(8), F11R(4), GNAI1(1), GNAI2(4), GNAI3(2), HCLS1(5), HRAS(3), IGSF5(7), INADL(32), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(11), MAGI1(23), MAGI2(19), MAGI3(10), MLLT4(10), MPDZ(9), MPP5(1), MRAS(1), MYH1(79), MYH10(13), MYH11(24), MYH13(30), MYH14(13), MYH15(45), MYH2(72), MYH3(17), MYH4(71), MYH6(30), MYH7(35), MYH7B(19), MYH8(48), MYH9(11), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLPF(1), NRAS(65), OCLN(3), PARD3(14), PARD6A(1), PARD6B(1), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PPP2R3A(6), PPP2R3B(4), PPP2R4(1), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), PTEN(18), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(7), SRC(1), SYMPK(4), TJAP1(4), TJP1(9), TJP2(8), TJP3(15), VAPA(1), YES1(5), ZAK(6)	63647314	1215	190	1106	690	768	100	65	171	109	2	0.174	1.000	1.000
129	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRB1(4), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(9), ATP1B3(1), ATP2A2(12), ATP2A3(13), ATP2B1(6), ATP2B2(22), ATP2B3(7), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1S(41), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CASQ1(8), CASQ2(3), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), GJA1(6), GJA4(4), GJA5(6), GJB1(1), GJB2(1), GJB3(3), GJB4(4), GJB5(5), GJB6(5), GNA11(6), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAZ(5), GNB3(5), GNB4(3), GNB5(2), GNG2(3), GNG4(1), GNG7(1), GRK4(7), GRK5(3), GRK6(3), ITPR1(21), ITPR2(15), ITPR3(6), KCNB1(30), KCNJ3(16), KCNJ5(11), MIB1(5), NME7(4), PKIA(2), PKIB(1), PKIG(1), PLCB3(3), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), RGS1(1), RGS11(2), RGS14(1), RGS16(2), RGS18(8), RGS20(2), RGS3(9), RGS4(1), RGS5(1), RGS6(13), RGS7(34), RGS9(9), RYR1(72), RYR2(77), RYR3(66), SFN(1), SLC8A1(26), SLC8A3(26), USP5(3), YWHAB(1), YWHAQ(3)	61247073	1167	187	1112	818	793	113	50	112	98	1	0.790	1.000	1.000
130	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(8), AKT3(4), CBL(8), CBLB(14), CBLC(10), CCND1(1), CCND2(3), CCND3(2), CISH(2), CNTF(1), CREBBP(17), CSF2(1), CSF2RA(17), CSF2RB(14), CSF3(3), CSF3R(2), EP300(13), EPO(5), EPOR(1), GH1(3), GH2(9), GHR(20), GRB2(1), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(4), IL10(3), IL10RA(6), IL10RB(5), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(5), IL19(2), IL2(2), IL20(4), IL20RA(9), IL21(6), IL21R(15), IL22(1), IL22RA1(8), IL23A(1), IL23R(7), IL26(2), IL28B(3), IL28RA(3), IL29(1), IL2RA(3), IL2RB(7), IL2RG(2), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(24), IL9(1), IL9R(4), IRF9(1), JAK1(5), JAK2(7), JAK3(4), LEP(2), LEPR(19), LIF(2), LIFR(28), MPL(7), MYC(4), OSM(5), OSMR(34), PIAS1(4), PIAS2(4), PIAS3(5), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIM1(1), PRL(1), PRLR(24), PTPN11(9), PTPN6(2), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(4), SOCS7(4), SOS1(7), SOS2(11), SPRED1(4), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(11), SPRY4(1), STAM(4), STAM2(1), STAT1(3), STAT2(5), STAT3(10), STAT4(20), STAT5A(2), STAT5B(4), STAT6(7), TPO(33), TSLP(1), TYK2(7)	47919524	832	187	804	387	534	63	35	115	84	1	0.0407	1.000	1.000
131	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADRB1(4), CSNK1D(1), DRD1(6), DRD2(13), EGF(14), EGFR(17), GJA1(6), GJD2(5), GNA11(6), GNAI1(1), GNAI2(4), GNAI3(2), GNAQ(4), GNAS(17), GRB2(1), GRM1(14), GRM5(10), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), HRAS(3), HTR2A(8), HTR2B(2), HTR2C(10), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K5(2), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(3), NPR1(11), NPR2(9), NRAS(65), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(6), PDGFRA(23), PDGFRB(11), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKG1(10), PRKG2(13), PRKX(3), RAF1(7), SOS1(7), SOS2(11), SRC(1), TJP1(9), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(12)	43276000	885	186	784	460	551	68	60	137	68	1	0.00876	1.000	1.000
132	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(3), ACTN2(16), ACTN3(7), ACTN4(5), DES(7), DMD(29), FAM48A(1), MYBPC1(16), MYBPC2(16), MYBPC3(14), MYH3(17), MYH6(30), MYH7(35), MYH8(48), MYL1(8), MYL2(4), MYL3(1), MYL4(3), MYL9(1), MYOM1(21), NEB(94), TCAP(1), TNNC2(4), TNNI2(2), TNNI3(1), TNNT1(1), TNNT2(3), TNNT3(3), TPM1(3), TPM2(2), TPM3(2), TPM4(2), TTN(914), VIM(5)	43726082	1321	185	1239	556	960	97	48	133	74	9	1.20e-06	1.000	1.000
133	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(2), ACTA2(3), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(4), ATF2(4), ATF4(7), ATF5(7), ATP2A2(12), ATP2A3(13), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CNN1(4), CNN2(1), CORIN(22), CREB3(1), CRH(3), CRHR1(6), DGKZ(6), ETS2(7), FOS(2), GABPB2(7), GBA2(2), GJA1(6), GNAQ(4), GNB3(5), GNB4(3), GNB5(2), GNG2(3), GNG4(1), GNG7(1), GRK4(7), GRK5(3), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(24), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP6(2), IL1B(6), IL6(2), ITPR1(21), ITPR2(15), ITPR3(6), JUN(1), MIB1(5), MYL2(4), MYL4(3), MYLK2(9), NFKB1(7), NOS1(48), NOS3(14), OXTR(5), PDE4B(7), PDE4D(7), PKIA(2), PKIB(1), PKIG(1), PLCB3(3), PLCD1(3), PLCG1(7), PLCG2(22), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), RAMP2(1), RAMP3(2), RGS1(1), RGS11(2), RGS14(1), RGS16(2), RGS18(8), RGS20(2), RGS3(9), RGS4(1), RGS5(1), RGS6(13), RGS7(34), RGS9(9), RLN1(1), RYR1(72), RYR2(77), RYR3(66), SFN(1), SLC8A1(26), SP1(3), TNXB(115), USP5(3), YWHAB(1), YWHAQ(3)	57243026	1046	184	999	608	726	92	40	108	79	1	0.0438	1.000	1.000
134	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(17), APC2(8), AXIN1(9), AXIN2(3), BTRC(4), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CCND1(1), CCND2(3), CCND3(2), CER1(12), CHD8(16), CHP(3), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(11), CTNNBIP1(1), CUL1(5), CXXC4(1), DAAM1(5), DAAM2(5), DKK1(2), DKK2(12), DKK4(2), DVL1(1), DVL2(4), DVL3(6), EP300(13), FBXW11(4), FZD1(4), FZD10(1), FZD2(5), FZD4(1), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(17), LRP6(19), MAP3K7(1), MAPK10(8), MAPK8(1), MAPK9(5), MMP7(4), MYC(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NKD1(6), NKD2(5), NLK(5), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PORCN(4), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRICKLE1(7), PRICKLE2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PSEN1(1), RAC1(16), RAC2(1), RHOA(1), ROCK1(4), ROCK2(13), RUVBL1(1), SENP2(10), SFRP1(2), SFRP2(9), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(4), TBL1X(5), TBL1XR1(1), TBL1Y(5), TCF7(1), TCF7L1(3), TCF7L2(6), TP53(37), VANGL1(2), VANGL2(8), WIF1(7), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3)	52868847	779	182	743	361	476	63	39	112	88	1	0.0245	1.000	1.000
135	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(4), ADRB2(2), AGTR1(9), AGTR2(10), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), CCBP2(8), CCKAR(9), CCKBR(8), CCR1(7), CCR10(2), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CCRL2(5), CHML(4), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CMKLR1(12), CNR1(7), CNR2(4), CX3CR1(11), CXCR3(3), CXCR4(3), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), EDNRA(8), EDNRB(4), F2R(5), F2RL1(14), F2RL2(5), F2RL3(3), FPR1(15), FSHR(13), GALR1(4), GALR3(2), GALT(2), GHSR(4), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(1), GPR3(2), GPR35(1), GPR37(7), GPR37L1(6), GPR4(3), GPR50(16), GPR6(5), GPR63(6), GPR77(5), GPR83(9), GPR85(5), GPR87(4), GRPR(4), HCRTR1(2), HCRTR2(24), HRH1(9), HRH2(2), HRH3(3), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), LHCGR(21), LTB4R(1), MAS1(3), MC3R(6), MC4R(1), MC5R(7), MTNR1A(7), MTNR1B(5), NMBR(6), NMUR1(5), NMUR2(12), NPY1R(23), NPY2R(11), NPY5R(20), NTSR1(5), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OR10A5(5), OR11A1(6), OR12D3(4), OR1C1(7), OR1F1(4), OR1Q1(6), OR2H1(6), OR5V1(8), OR7A5(2), OR7C1(1), OR8B8(9), OXTR(5), P2RY1(4), P2RY10(6), P2RY12(2), P2RY13(4), P2RY14(5), P2RY2(7), P2RY6(1), PPYR1(10), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), RGR(5), RHO(1), RRH(1), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), SUCNR1(7), TBXA2R(4), TRHR(17)	39855752	970	181	921	712	645	96	34	127	68	0	0.00368	1.000	1.000
136	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(8), AKT3(4), BRAF(120), DAG1(5), DRD2(13), EGFR(17), EPHB2(21), GRB2(1), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), PI3(5), PIK3CB(21), PITX2(4), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), RAF1(7), RGS20(2), SHC1(1), SOS1(7), SOS2(11), SRC(1), STAT3(10), TERF2IP(1)	19275502	456	181	330	167	221	29	26	149	30	1	0.000558	1.000	1.000
137	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(4), CADM1(3), CADM3(16), CD2(21), CD22(17), CD226(6), CD274(1), CD276(5), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(1), CD58(1), CD6(5), CD80(4), CD86(18), CD8A(2), CD8B(5), CD99(1), CDH1(4), CDH15(6), CDH2(10), CDH4(27), CDH5(8), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(19), CNTN2(12), CNTNAP1(11), CNTNAP2(69), CTLA4(2), F11R(4), GLG1(5), HLA-A(3), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(5), HLA-G(2), ICAM1(1), ICAM2(3), ICOS(3), ICOSLG(1), ITGA4(29), ITGA6(6), ITGA8(27), ITGA9(8), ITGAL(19), ITGAM(17), ITGAV(9), ITGB1(4), ITGB2(10), ITGB7(5), ITGB8(16), JAM2(10), JAM3(2), L1CAM(8), MADCAM1(1), MAG(7), MPZ(3), MPZL1(1), NCAM1(10), NCAM2(7), NEGR1(6), NEO1(12), NFASC(26), NLGN1(10), NLGN2(4), NLGN3(6), NRCAM(7), NRXN1(35), NRXN2(12), NRXN3(23), OCLN(3), PDCD1(3), PDCD1LG2(3), PTPRC(26), PTPRF(25), PTPRM(6), PVR(3), PVRL1(4), PVRL2(5), PVRL3(5), SDC1(3), SDC2(2), SDC3(5), SDC4(2), SELE(28), SELL(7), SELP(28), SELPLG(8), SIGLEC1(14), SPN(3), VCAM1(13), VCAN(28)	48160803	1002	180	958	455	674	80	41	124	83	0	3.49e-05	1.000	1.000
138	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(4), BRAF(120), CHUK(2), DAXX(8), ELK1(2), FOS(2), GRB2(1), HRAS(3), IKBKB(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K6(4), MAP3K7(1), MAP3K9(20), MAP4K1(8), MAP4K2(4), MAP4K3(7), MAP4K4(6), MAP4K5(2), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK4(14), MAPK6(4), MAPK7(3), MAPK8(1), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(3), MKNK2(1), MYC(4), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(16), RAF1(7), RELA(4), RIPK1(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(3), RPS6KB1(2), RPS6KB2(2), SHC1(1), SP1(3), STAT1(3), TGFB1(1), TGFB3(3), TRAF2(1)	31127543	468	179	345	173	218	37	21	160	32	0	0.0253	1.000	1.000
139	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(18), BDKRB1(3), BDKRB2(9), C1QA(3), C1QB(3), C1QC(6), C1R(8), C1S(11), C2(12), C3(36), C3AR1(4), C4BPA(14), C4BPB(5), C5(9), C5AR1(9), C6(50), C7(44), C8A(29), C8B(34), C8G(1), C9(16), CD55(4), CD59(1), CFB(26), CFH(41), CFI(12), CPB2(1), CR1(47), CR2(26), F10(7), F11(9), F12(1), F13A1(21), F13B(19), F2(9), F2R(5), F5(24), F7(7), F8(40), F9(11), FGA(32), FGB(6), FGG(7), KLKB1(19), KNG1(8), MASP1(6), MASP2(6), MBL2(10), PLAT(3), PLAU(1), PLAUR(2), PLG(25), PROC(4), PROS1(12), SERPINA1(5), SERPINA5(10), SERPINC1(6), SERPIND1(3), SERPINE1(5), SERPINF2(5), SERPING1(10), TFPI(7), THBD(3), VWF(40)	29716444	870	176	823	355	600	64	38	93	74	1	9.52e-05	1.000	1.000
140	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ATF4(7), CACNA1C(32), CACNA1D(23), CACNA1F(18), CACNA1S(41), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CDC42(2), CGA(1), EGFR(17), ELK1(2), FSHB(4), GNA11(6), GNAQ(4), GNAS(17), GNRH2(2), GNRHR(1), GRB2(1), HBEGF(1), HRAS(3), ITPR1(21), ITPR2(15), ITPR3(6), JUN(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(5), MMP14(2), MMP2(6), NRAS(65), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLD1(9), PLD2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCD(4), PRKX(3), PTK2B(8), RAF1(7), SOS1(7), SOS2(11), SRC(1)	41472822	762	175	669	440	456	66	57	119	63	1	0.303	1.000	1.000
141	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ASIP(1), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CREB3(1), CREB3L1(3), CREB3L2(6), CREB3L3(9), CREB3L4(5), CREBBP(17), CTNNB1(11), DCT(2), DVL1(1), DVL2(4), DVL3(6), EDN1(7), EDNRB(4), EP300(13), FZD1(4), FZD10(1), FZD2(5), FZD4(1), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GNAI1(1), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(17), GSK3B(2), HRAS(3), KIT(8), KITLG(6), KRAS(4), LEF1(3), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MITF(4), NRAS(65), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), POMC(1), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), RAF1(7), TCF7(1), TCF7L1(3), TCF7L2(6), TYR(7), TYRP1(8), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3)	35525112	655	175	569	332	371	56	52	112	63	1	0.0334	1.000	1.000
142	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), AKAP1(7), AKAP10(3), AKAP11(11), AKAP12(3), AKAP3(16), AKAP4(12), AKAP6(26), AKAP7(3), AKAP8(6), AKAP9(26), ARHGEF1(1), CALM1(1), CALM2(1), GNA11(6), GNA12(3), GNA13(1), GNA14(4), GNA15(5), GNAI2(4), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(4), GNAZ(5), GNB3(5), GNB5(2), GNG4(1), GNG7(1), GNGT2(3), HRAS(3), ITPR1(21), KCNJ3(16), KRAS(4), NRAS(65), PDE1A(32), PDE1B(10), PDE1C(37), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(19), PLCB3(3), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(3), USP5(3)	38481844	652	174	578	343	398	49	52	110	43	0	0.182	1.000	1.000
143	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADK(4), ADSL(3), ADSS(2), ADSSL1(7), AK2(3), AK5(5), AK7(18), ALLC(7), AMPD1(24), AMPD2(5), AMPD3(20), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(10), ENPP3(14), ENTPD1(7), ENTPD2(2), ENTPD3(5), ENTPD4(3), ENTPD5(1), ENTPD6(4), ENTPD8(2), FHIT(2), GART(9), GDA(10), GMPR2(1), GMPS(1), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(2), NME7(4), NPR1(11), NPR2(9), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(5), PDE10A(10), PDE11A(14), PDE1A(32), PDE1C(37), PDE2A(11), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE5A(7), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(19), PDE9A(8), PFAS(7), PKLR(8), PKM2(3), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(12), PRPS1(2), PRPS1L1(11), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2), RRM2B(2), XDH(44)	53852189	885	174	851	437	598	65	48	100	74	0	0.00338	1.000	1.000
144	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(8), AKT3(4), BRAF(120), CAB39(1), EIF4B(3), EIF4EBP1(1), FIGF(3), HIF1A(5), IGF1(9), MAPK1(4), MAPK3(1), PDPK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PRKAA1(1), PRKAA2(19), RHEB(1), RICTOR(9), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(2), STK11(3), TSC1(5), TSC2(11), ULK1(7), ULK2(6), ULK3(1), VEGFA(5), VEGFB(1), VEGFC(17)	17361413	365	172	247	100	152	18	15	150	28	2	5.58e-05	1.000	1.000
145	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(10), ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(5), ATM(11), ATR(18), BUB1(3), BUB1B(8), CCNA1(13), CCNB2(3), CCNB3(26), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDC14A(4), CDC16(1), CDC20(1), CDC23(3), CDC25A(7), CDC25B(4), CDC25C(2), CDC27(9), CDC6(1), CDC7(2), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(31), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(17), CUL1(5), DBF4(5), E2F1(4), E2F2(4), E2F3(5), EP300(13), ESPL1(9), FZR1(6), GADD45B(2), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(16), PTTG2(5), RB1(8), RBL1(10), RBL2(4), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(18), TFDP1(2), TGFB1(1), TGFB3(3), TP53(37), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	45052896	492	170	460	166	253	34	36	92	75	2	0.000154	1.000	1.000
146	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), ARHGAP5(10), BCAR1(4), CD99(1), CDC42(2), CDH5(8), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(7), EZR(1), F11R(4), GNAI1(1), GNAI2(4), GNAI3(2), GRLF1(10), ICAM1(1), ITGA4(29), ITGAL(19), ITGAM(17), ITGB1(4), ITGB2(10), ITK(19), JAM2(10), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MLLT4(10), MMP2(6), MMP9(4), MSN(1), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLPF(1), NCF1(1), NCF2(7), NCF4(4), NOX1(10), NOX3(4), OCLN(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PRKCA(10), PRKCG(13), PTK2(8), PTK2B(8), PTPN11(9), PXN(3), RAC1(16), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(10), RAPGEF4(10), RASSF5(5), RHOA(1), RHOH(4), ROCK1(4), ROCK2(13), SIPA1(7), THY1(1), TXK(8), VASP(3), VAV1(13), VAV2(2), VAV3(8), VCAM1(13), VCL(7)	40673936	688	170	655	317	445	48	23	102	68	2	0.000926	1.000	1.000
147	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ATF1(4), BRAF(120), CAMP(1), CREB3(1), CREB5(7), CREBBP(17), CRKL(2), DAG1(5), EGR1(4), EGR2(3), EGR3(2), EGR4(5), ELK1(2), FRS2(4), GNAQ(4), JUN(1), MAP1B(18), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), NTRK1(12), OPN1LW(3), PIK3C2G(39), PIK3CA(6), PIK3CD(7), PIK3R1(3), PTPN11(9), RPS6KA3(2), SHC1(1), SRC(1), TERF2IP(1), TH(7)	16844359	339	170	226	101	152	18	13	133	22	1	0.000584	1.000	1.000
148	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(8), AKT3(4), BCL10(2), CARD11(29), CBL(8), CBLB(14), CBLC(10), CD247(2), CD28(1), CD3D(4), CD3G(1), CD4(6), CD40LG(1), CD8A(2), CD8B(5), CDC42(2), CDK4(5), CHP(3), CHUK(2), CSF2(1), CTLA4(2), FOS(2), FYN(5), GRAP2(4), GRB2(1), HRAS(3), ICOS(3), IFNG(1), IKBKB(3), IL10(3), IL2(2), IL4(1), IL5(2), ITK(19), JUN(1), KRAS(4), LAT(1), LCK(10), LCP2(9), MALT1(6), MAP3K14(3), NCK1(1), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NRAS(65), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDCD1(3), PDK1(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKCQ(13), PTPN6(2), PTPRC(26), RASGRP1(6), RHOA(1), SOS1(7), SOS2(11), TEC(9), TNF(1), VAV1(13), VAV2(2), VAV3(8), ZAP70(4)	33409737	604	169	527	244	335	43	48	130	47	1	0.00704	1.000	1.000
149	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(16), AMY2A(4), AMY2B(10), ASCC3(10), ATP13A2(8), DDX18(4), DDX19A(1), DDX23(5), DDX4(10), DDX41(5), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(2), DDX56(3), DHX58(4), ENPP1(10), ENPP3(14), ENTPD7(2), EP400(18), ERCC2(2), ERCC3(1), G6PC(4), G6PC2(3), GAA(6), GANC(5), GBA(3), GBA3(14), GBE1(7), GCK(15), GPI(3), GUSB(3), GYS1(3), GYS2(13), HK1(3), HK2(11), HK3(12), IFIH1(13), MGAM(124), MOV10L1(23), NUDT5(2), NUDT8(1), PGM1(4), PGM3(1), PYGB(2), PYGL(6), PYGM(9), RAD54B(5), RUVBL2(4), SETX(13), SI(67), SKIV2L2(5), SMARCA2(10), SMARCA5(5), TREH(2), UGDH(1), UGP2(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), UXS1(4)	40454669	786	168	741	332	527	65	37	76	80	1	0.000132	1.000	1.000
150	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1C1(1), AKR1C2(5), AKR1C3(7), AKR1C4(7), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), CYP1A1(8), CYP1A2(10), CYP1B1(2), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2F1(9), CYP2S1(8), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), DHDH(3), EPHX1(2), GSTA1(5), GSTA2(2), GSTA5(3), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15)	18838459	636	167	585	272	461	44	36	44	50	1	1.95e-07	1.000	1.000
151	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(15), CD14(4), CD19(7), CD1A(8), CD1B(11), CD1C(23), CD1D(5), CD1E(16), CD2(21), CD22(17), CD33(15), CD34(4), CD36(4), CD37(3), CD38(2), CD3D(4), CD3G(1), CD4(6), CD44(5), CD5(5), CD55(4), CD59(1), CD8A(2), CD8B(5), CR1(47), CR2(26), CSF1(7), CSF1R(10), CSF2(1), CSF2RA(17), CSF3(3), CSF3R(2), DNTT(7), EPO(5), EPOR(1), FCER2(3), FCGR1A(5), FLT3(28), FLT3LG(2), GP5(3), GP9(4), GYPA(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), IL11RA(2), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), IL2RA(3), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL7(5), IL7R(24), IL9R(4), ITGA1(16), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGAM(17), ITGB3(9), KIT(8), KITLG(6), MME(17), MS4A1(7), TFRC(4), THPO(6), TNF(1), TPO(33)	26768220	678	167	647	303	484	34	27	54	79	0	0.000754	1.000	1.000
152	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(1), CALML3(5), CDS1(6), CDS2(4), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPP5B(5), INPP5D(24), INPPL1(14), ITPK1(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), OCRL(4), PI4KA(18), PI4KB(5), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3C3(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), PRKCA(10), PRKCG(13), PTEN(18), SYNJ1(18), SYNJ2(13)	40761971	697	166	657	309	457	37	30	97	74	2	0.000363	1.000	1.000
153	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(17), AR(3), BRAF(120), CAMP(1), CCL15(2), CCL16(1), DAG1(5), EGFR(17), GNA11(6), GNA15(5), GNAI1(1), GNAQ(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), MAPK10(8), MAPK14(5), PHKA2(7), PIK3CA(6), PIK3CD(7), PIK3R1(3), PITX2(4), PTX3(1), RAF1(7), SRC(1)	17495780	316	166	207	111	126	18	18	130	23	1	0.0189	1.000	1.000
154	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(8), AKT3(4), BCL10(2), BLNK(8), BTK(15), CARD11(29), CD19(7), CD22(17), CD72(4), CD79A(2), CD79B(1), CHP(3), CHUK(2), CR2(26), FCGR2B(2), FOS(2), GSK3B(2), HRAS(3), IKBKB(3), INPP5D(24), JUN(1), KRAS(4), LILRB3(5), LYN(5), MALT1(6), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NRAS(65), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PTPN6(2), RAC1(16), RAC2(1), RASGRP3(11), SYK(12), VAV1(13), VAV2(2), VAV3(8)	24554678	493	164	420	170	268	25	47	109	43	1	9.57e-06	1.000	1.000
155	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(4), BCAR1(4), CAPN1(4), CAPN10(5), CAPN11(8), CAPN2(7), CAPN3(7), CAPN5(5), CAPN6(11), CAPN7(1), CAPN9(10), CAPNS1(1), CAV1(1), CDC42(2), CRK(2), CSK(1), DOCK1(12), FYN(5), GIT2(7), GRB2(1), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAD(17), ITGAE(12), ITGAL(19), ITGAM(17), ITGAV(9), ITGAX(15), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAPK10(8), MAPK12(1), MAPK4(14), MAPK6(4), MAPK7(3), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC1(16), RAC2(1), RAP1B(1), RAPGEF1(9), RHO(1), ROCK1(4), ROCK2(13), SDCCAG8(2), SHC1(1), SHC3(8), SORBS1(10), SOS1(7), SRC(1), TLN1(11), TNS1(7), VASP(3), VAV2(2), VAV3(8), VCL(7), ZYX(6)	43739895	638	163	613	290	415	48	23	92	59	1	0.00338	1.000	1.000
156	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(8), AKT3(4), CASP8(7), CD14(4), CD40(4), CD80(4), CD86(18), CHUK(2), CXCL10(2), CXCL9(1), FOS(2), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(3), IKBKE(8), IL12A(2), IL12B(1), IL1B(6), IL6(2), IL8(1), IRAK1(4), IRAK4(3), IRF3(3), IRF5(4), IRF7(7), JUN(1), LBP(6), LY96(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MYD88(4), NFKB1(7), NFKB2(4), NFKBIA(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), RAC1(16), RELA(4), RIPK1(1), SPP1(6), STAT1(3), TBK1(4), TICAM1(7), TIRAP(1), TLR1(10), TLR2(13), TLR3(8), TLR4(25), TLR5(16), TLR6(5), TLR7(15), TLR8(8), TLR9(12), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	29489187	483	162	459	202	297	30	24	85	46	1	0.000701	1.000	1.000
157	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(8), AKT3(4), BTK(15), CSF2(1), FCER1A(12), FYN(5), GAB2(3), GRB2(1), HRAS(3), IL3(2), IL4(1), IL5(2), INPP5D(24), KRAS(4), LAT(1), LCP2(9), LYN(5), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MS4A2(9), NRAS(65), PDK1(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCG1(7), PLCG2(22), PRKCA(10), PRKCD(4), PRKCE(5), RAC1(16), RAC2(1), RAF1(7), SOS1(7), SOS2(11), SYK(12), TNF(1), VAV1(13), VAV2(2), VAV3(8)	23773895	488	162	407	165	264	27	40	112	44	1	7.20e-06	1.000	1.000
158	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(10), ABCA10(18), ABCA12(48), ABCA13(51), ABCA2(7), ABCA3(15), ABCA4(43), ABCA5(7), ABCA6(20), ABCA7(9), ABCA8(26), ABCA9(15), ABCB1(28), ABCB10(5), ABCB11(37), ABCB4(13), ABCB5(33), ABCB6(2), ABCB7(4), ABCB8(2), ABCB9(6), ABCC1(10), ABCC10(10), ABCC11(15), ABCC12(20), ABCC2(7), ABCC3(19), ABCC4(11), ABCC5(8), ABCC6(21), ABCC8(31), ABCC9(47), ABCD2(16), ABCD3(8), ABCD4(1), ABCG1(7), ABCG2(5), ABCG4(5), ABCG5(6), ABCG8(14), CFTR(38), TAP1(1), TAP2(11)	38824639	710	161	681	409	460	59	29	84	78	0	0.0576	1.000	1.000
159	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(8), AKT3(4), CASP9(2), CDC42(2), CHP(3), HRAS(3), KDR(32), KRAS(4), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPKAPK2(5), MAPKAPK3(3), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NOS3(14), NRAS(65), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCG1(7), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKCA(10), PRKCG(13), PTGS2(9), PTK2(8), PXN(3), RAC1(16), RAC2(1), RAF1(7), SH2D2A(2), SHC2(5), SPHK1(1), SPHK2(6), SRC(1), VEGFA(5)	23743907	476	159	396	169	261	21	35	115	43	1	3.80e-05	1.000	1.000
160	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(10), ATM(11), BUB1(3), BUB1B(8), CCNA1(13), CCNB2(3), CCNB3(26), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDAN1(4), CDC14A(4), CDC20(1), CDC25A(7), CDC25B(4), CDC25C(2), CDC6(1), CDC7(2), CDH1(4), CDK4(5), CDKN1A(4), CDKN2A(31), CHEK1(1), CHEK2(2), DTX4(4), E2F1(4), E2F2(4), E2F3(5), E2F4(1), E2F5(1), EP300(13), ESPL1(9), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(8), HDAC5(6), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), MPEG1(5), MPL(7), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(16), PTPRA(6), PTTG2(5), RB1(8), RBL1(10), SKP2(2), SMAD4(2), TBC1D8(8), TFDP1(2), TGFB1(1), TP53(37), WEE1(2)	36211601	406	158	378	146	219	31	21	69	64	2	0.000409	1.000	1.000
161	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(6), ALG14(2), ALG2(4), ALG3(4), ALG6(2), ALG8(5), ALG9(4), B3GNT1(2), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(5), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(5), CHST12(3), CHST13(2), CHST14(2), CHST2(3), CHST3(1), CHST4(8), CHST6(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(1), EXT2(6), EXTL1(2), EXTL3(9), FUT11(3), FUT8(7), GALNT1(4), GALNT10(6), GALNT11(1), GALNT12(6), GALNT13(23), GALNT14(23), GALNT2(5), GALNT3(3), GALNT4(3), GALNT5(8), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GALNTL1(4), GALNTL2(17), GALNTL4(6), GALNTL5(12), GANAB(3), GCNT1(6), GCNT3(5), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(4), HS6ST1(3), HS6ST2(2), HS6ST3(9), MAN1A1(13), MAN1A2(4), MAN1B1(3), MAN1C1(4), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), NDST1(4), NDST2(2), NDST3(22), NDST4(41), OGT(9), RPN2(2), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(3), STT3B(5), WBSCR17(36), XYLT1(8), XYLT2(3)	35984285	578	158	556	297	382	43	27	69	57	0	0.0603	1.000	1.000
162	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADK(4), ADSL(3), ADSS(2), AK2(3), AK5(5), ALLC(7), AMPD1(24), AMPD2(5), AMPD3(20), APRT(3), ATIC(5), ATP5B(1), ATP5C1(2), ATP5F1(5), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(10), ENPP3(14), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(10), GMPS(1), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(11), NPR2(9), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(5), PDE1A(32), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE5A(7), PDE6B(10), PDE6C(20), PDE6G(2), PDE7B(16), PDE8A(2), PDE9A(8), PFAS(7), PKLR(8), PKM2(3), POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(11), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2)	42124148	666	156	635	337	456	50	26	74	60	0	0.00883	1.000	1.000
163	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(3), ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), ACVR1B(2), ACVR1C(7), BAIAP2(5), CDC42(2), CDH1(4), CREBBP(17), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTNND1(9), EGFR(17), EP300(13), ERBB2(7), FARP2(5), FER(2), FGFR1(11), FYN(5), IGF1R(9), INSR(19), IQGAP1(8), LEF1(3), LMO7(18), MAP3K7(1), MAPK1(4), MAPK3(1), MET(19), MLLT4(10), NLK(5), PARD3(14), PTPN1(4), PTPN6(2), PTPRB(64), PTPRF(25), PTPRJ(7), PTPRM(6), PVRL1(4), PVRL2(5), PVRL3(5), PVRL4(6), RAC1(16), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(1), SNAI2(4), SORBS1(10), SRC(1), SSX2IP(5), TCF7(1), TCF7L1(3), TCF7L2(6), TGFBR2(7), TJP1(9), VCL(7), WAS(6), WASF1(3), WASF2(3), WASF3(11), WASL(5), YES1(5)	39629486	565	155	536	269	366	44	25	69	60	1	0.153	1.000	1.000
164	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(16), AMY2A(4), AMY2B(10), ENPP1(10), ENPP3(14), G6PC(4), GAA(6), GANAB(3), GBA3(14), GBE1(7), GCK(15), GPI(3), GUSB(3), GYS1(3), GYS2(13), HK1(3), HK2(11), HK3(12), MGAM(124), PGM1(4), PGM3(1), PYGB(2), PYGL(6), PYGM(9), SI(67), UCHL1(3), UCHL3(2), UGDH(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27), UXS1(4)	18681871	490	155	457	207	337	49	22	41	40	1	0.000577	1.000	1.000
165	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(21), ASH2L(3), CARM1(6), CTCFL(16), DOT1L(7), EED(1), EHMT1(7), EHMT2(9), EZH1(4), EZH2(10), FBXO11(6), HCFC1(14), JMJD4(4), JMJD6(1), KDM6A(3), MEN1(2), MLL(34), MLL2(42), MLL3(53), MLL4(28), MLL5(11), NSD1(14), OGT(9), PAXIP1(2), PPP1CB(5), PPP1CC(2), PRDM2(11), PRDM7(5), PRDM9(41), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(3), SATB1(11), SETD1A(22), SETD2(12), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(3), SMYD3(2), STK38(4), SUV39H1(1), SUV39H2(1), SUV420H1(7), SUV420H2(1), SUZ12(2), WHSC1(8), WHSC1L1(6)	38938961	487	154	471	165	307	46	22	66	46	0	0.00130	1.000	1.000
166	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(5), ATM(11), BAX(3), BCL2(2), BIRC2(3), BIRC3(6), CAPN1(4), CAPN2(7), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHP(3), CHUK(2), CSF2RB(14), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(12), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1RAP(4), IL3(2), IL3RA(5), IRAK1(4), IRAK2(9), IRAK3(5), IRAK4(3), MAP3K14(3), MYD88(4), NFKB1(7), NFKB2(4), NFKBIA(2), NTRK1(12), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(4), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFRSF1A(2), TNFSF10(7), TP53(37), TRAF2(1)	27395604	393	152	380	183	224	24	21	71	52	1	0.208	1.000	1.000
167	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(9), AGTR2(10), ATP8A1(19), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), CCKAR(9), CCKBR(8), CCR1(7), CCR10(2), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(3), CXCR6(4), EDNRA(8), EDNRB(4), FPR1(15), FSHR(13), GALR1(4), GALR3(2), GALT(2), GHSR(4), GNB2L1(3), GNRHR(1), GPR77(5), GRPR(4), LHCGR(21), MC2R(5), MC3R(6), MC4R(1), MC5R(7), NMBR(6), NPY1R(23), NPY2R(11), NPY5R(20), NTSR1(5), NTSR2(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OXTR(5), PPYR1(10), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), TACR1(6), TACR2(6), TACR3(21), TRHR(17), TSHR(6)	17248969	461	152	436	304	316	40	18	54	33	0	0.00172	1.000	1.000
168	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(2), ACVRL1(8), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(4), BUB1(3), CDKL1(4), CDKL2(1), CDS1(6), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPPL1(14), ITPKB(5), MAP3K10(7), MOS(3), NEK1(6), NEK3(2), OCRL(4), PAK4(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3CA(6), PIK3CB(21), PIK3CG(21), PIM2(4), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCG1(7), PLCG2(22), PLK3(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), PRKG1(10), RAF1(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(3)	36998017	559	149	530	298	375	28	21	77	57	1	0.533	1.000	1.000
169	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(2), ACVR1C(7), ACVR2A(4), ACVR2B(3), ACVRL1(8), AMHR2(14), BMP2(3), BMP4(2), BMP5(21), BMP6(7), BMP7(1), BMP8A(2), BMP8B(1), BMPR1A(1), BMPR1B(3), BMPR2(4), CHRD(10), COMP(4), CREBBP(17), CUL1(5), DCN(15), E2F4(1), E2F5(1), EP300(13), FST(4), GDF5(11), GDF6(2), GDF7(2), ID2(2), IFNG(1), INHBA(12), INHBB(4), INHBC(10), INHBE(3), LEFTY1(6), LEFTY2(3), LTBP1(33), MAPK1(4), MAPK3(1), MYC(4), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), RBL1(10), RBL2(4), RHOA(1), ROCK1(4), ROCK2(13), RPS6KB1(2), RPS6KB2(2), SMAD1(5), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(2), SMAD6(6), SMAD7(2), SMAD9(9), SMURF1(1), SMURF2(9), SP1(3), TFDP1(2), TGFB1(1), TGFB3(3), TGFBR2(7), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNF(1), ZFYVE16(3), ZFYVE9(7)	32712263	432	148	421	203	275	39	19	56	43	0	0.239	1.000	1.000
170	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), F10(7), F11(9), F12(1), F2(9), F2R(5), F5(24), F8(40), F9(11), FGA(32), FGB(6), FGG(7), KLKB1(19), PROC(4), PROS1(12), SERPINC1(6), SERPING1(10)	14637957	460	147	440	140	345	32	19	43	21	0	0.0557	1.000	1.000
171	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(7), AKR1D1(17), ARSD(3), ARSE(5), CARM1(6), CYP11B1(11), CYP11B2(11), CYP19A1(9), HEMK1(4), HSD11B1(10), HSD11B2(2), HSD17B12(2), HSD17B2(7), HSD17B3(3), HSD17B7(1), HSD3B1(10), HSD3B2(7), LCMT1(3), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(2), SRD5A2(5), STS(6), SULT1E1(10), SULT2A1(6), SULT2B1(5), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), WBSCR22(1)	16431976	418	146	394	178	282	40	23	30	42	1	0.000120	1.000	1.000
172	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AGK(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AKR1A1(3), AKR1B1(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CEL(11), DAK(3), DGAT1(1), DGAT2(4), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), GK(6), GK2(33), GLA(1), GLB1(7), GPAM(2), LCT(29), LIPA(4), LIPC(8), LIPF(14), LIPG(5), LPL(3), MGLL(6), PNLIP(3), PNLIPRP1(7), PNLIPRP2(2), PNPLA3(2), PPAP2B(5), PPAP2C(6)	19411878	409	146	375	180	273	39	17	51	29	0	0.00137	1.000	1.000
173	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPP5B(5), INPPL1(14), IPMK(1), ITPK1(4), ITPKB(5), MINPP1(1), MIOX(2), OCRL(4), PI4KA(18), PI4KB(5), PIK3C3(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), PTEN(18), SYNJ1(18), SYNJ2(13)	24302605	424	146	401	175	264	23	22	69	45	1	0.00131	1.000	1.000
174	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(15), ACAT2(1), ACMSD(9), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(18), ASMT(5), CAT(5), CYP19A1(9), CYP1A1(8), CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2D6(1), CYP2E1(12), CYP2F1(9), CYP2J2(3), CYP3A4(16), CYP3A5(10), CYP3A7(12), CYP4B1(17), CYP4F8(11), DDC(12), ECHS1(1), EHHADH(5), GCDH(5), HAAO(3), HADHA(8), KMO(7), KYNU(10), MAOA(2), MAOB(11), SDS(2), TDO2(4), TPH1(5), WARS(4), WARS2(4)	18076614	457	145	435	257	339	30	19	38	31	0	0.0694	1.000	1.000
175	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(11), CCNA1(13), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDC25A(7), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(31), CDKN2C(1), CREB3(1), CREB3L1(3), CREB3L3(9), CREB3L4(5), E2F1(4), E2F2(4), E2F3(5), E2F4(1), E2F5(1), GBA2(2), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), MNAT1(2), MYC(4), MYT1(19), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLE(14), POLE2(3), PRIM1(3), RB1(8), RBL1(10), RPA1(3), RPA2(2), RPA3(1), TFDP1(2), TFDP2(4), TNXB(115), TP53(37), WEE1(2)	26096481	416	143	381	147	233	24	16	74	67	2	0.000134	1.000	1.000
176	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(5), ATM(11), ATR(18), BAI1(13), BAX(3), CASP3(2), CASP8(7), CASP9(2), CCNB2(3), CCNB3(26), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNG1(1), CDK4(5), CDK6(2), CDKN1A(4), CDKN2A(31), CHEK1(1), CHEK2(2), CYCS(1), DDB2(1), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(9), IGFBP3(2), LRDD(4), MDM2(3), MDM4(2), PERP(2), PTEN(18), RFWD2(4), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(7), SERPINE1(5), SESN2(4), SESN3(1), SFN(1), STEAP3(6), THBS1(21), TNFRSF10B(1), TP53(37), TP53I3(2), TP73(5), TSC2(11), ZMAT3(1)	21382628	328	143	297	112	160	22	24	52	69	1	0.00159	1.000	1.000
177	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(4), CLK2(6), CLK3(2), COL2A1(27), CPSF1(6), CPSF2(2), CPSF3(4), CSTF1(4), CSTF2(4), CSTF2T(2), CSTF3(4), DDIT3(2), DDX1(2), DDX20(7), DHX15(4), DHX16(7), DHX38(7), DHX8(9), DHX9(8), DICER1(16), DNAJC8(2), GIPC1(3), LOC440563(17), LSM2(2), LSM7(1), METTL3(1), NCBP1(1), NONO(8), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(10), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(1), PRPF4B(5), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(6), RBM17(1), RBM5(6), RNGTT(1), RNMT(5), RNPS1(1), SF3A1(6), SF3A2(5), SF3A3(4), SF3B1(14), SF3B2(9), SF3B4(4), SF4(8), SFRS12(2), SFRS14(9), SFRS16(3), SFRS4(2), SFRS5(2), SFRS6(1), SFRS7(2), SFRS8(6), SFRS9(2), SNRPA(2), SNRPA1(1), SNRPB(4), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(4), SNURF(2), SPOP(2), SRPK1(7), SRPK2(2), SRRM1(6), SUPT5H(5), TXNL4A(1), U2AF2(3), XRN2(4)	35101502	359	142	354	155	212	29	22	49	47	0	0.455	1.000	1.000
178	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(8), AKT3(4), CDC42(2), CDKN1B(1), CDKN2A(31), CREB3(1), CREB5(7), ERBB4(45), F2RL2(5), GAB1(2), GRB2(1), GSK3B(2), IGF1(9), IGFBP1(3), INPPL1(14), IRS1(5), IRS2(2), IRS4(9), MET(19), MYC(4), NOLC1(3), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PARD3(14), PARD6A(1), PDK1(2), PIK3CA(6), PIK3CD(7), PPP1R13B(6), PREX1(7), PTEN(18), PTK2(8), PTPN1(4), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(7), SOS1(7), SOS2(11), TSC1(5), TSC2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	25481760	386	142	356	162	207	35	20	55	68	1	0.0348	1.000	1.000
179	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(11), ALG6(2), CCKBR(8), CCR2(15), CCR3(8), CCR5(6), CELSR1(20), CELSR2(22), CELSR3(31), CHRM2(17), CHRM3(17), CXCR3(3), DRD4(1), EDNRA(8), EMR2(4), EMR3(15), F2R(5), FSHR(13), GHRHR(3), GNRHR(1), GPR116(28), GPR132(3), GPR133(12), GPR143(3), GPR17(1), GPR18(5), GPR55(2), GPR56(4), GPR61(8), GPR77(5), GPR84(7), GRM1(14), GRPR(4), HRH4(5), LGR6(15), LPHN2(30), LPHN3(17), LTB4R2(1), NTSR1(5), OR2M4(10), OR8G2(13), P2RY13(4), PTGFR(18), SMO(10), SSTR2(5), TAAR5(3), TSHR(6)	21917759	448	141	431	293	288	40	20	63	36	1	0.281	1.000	1.000
180	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(5), ACADL(4), ACADM(5), ACOX1(7), ACOX2(5), ACOX3(11), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADIPOQ(3), ANGPTL4(4), APOA1(1), APOA5(4), AQP7(2), CD36(4), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), CYP27A1(3), CYP4A11(19), CYP4A22(16), CYP7A1(6), CYP8B1(9), DBI(1), EHHADH(5), FABP1(6), FABP2(5), FABP4(1), FADS2(3), GK(6), GK2(33), HMGCS2(16), LPL(3), ME1(17), MMP1(10), NR1H3(2), OLR1(2), PCK1(16), PCK2(4), PDPK1(4), PLTP(1), PPARA(6), PPARD(2), PPARG(11), RXRA(4), RXRB(4), RXRG(4), SCD(3), SCP2(2), SLC27A1(3), SLC27A2(11), SLC27A4(2), SLC27A5(6), SLC27A6(24), SORBS1(10), UBC(4), UCP1(3)	21650472	413	141	393	207	289	33	16	40	35	0	0.0453	1.000	1.000
181	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(6), BCL2(2), CABIN1(9), CALM1(1), CALM2(1), CAMK2B(4), CAMK4(8), CD3G(1), CD69(3), CDKN1A(4), CNR1(7), CREBBP(17), CSF2(1), CSNK2A1(1), CSNK2B(1), CTLA4(2), EGR2(3), EGR3(2), EP300(13), FCER1A(12), FCGR3A(6), FOS(2), GATA3(5), GATA4(2), GRLF1(10), GSK3B(2), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL1B(6), IL2(2), IL2RA(3), IL3(2), IL4(1), IL6(2), IL8(1), ITK(19), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(1), MAPK9(5), MEF2A(4), MEF2B(2), MEF2D(4), MYF5(11), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB2(4), NFKBIB(1), NPPB(3), NUP214(11), OPRD1(2), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(26), RELA(4), RPL13A(1), SFN(1), SLA(2), SP1(3), TGFB1(1), TNF(1), TRAF2(1), TRPV6(25), VAV1(13), VAV2(2), VAV3(8), XPO5(7)	30019156	395	140	381	194	262	23	21	47	42	0	0.180	1.000	1.000
182	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(8), AKT3(4), BCR(10), BTK(15), CD19(7), CDKN2A(31), DAPP1(4), FLOT1(2), GAB1(2), ITPR1(21), ITPR2(15), ITPR3(6), LYN(5), NR0B2(3), PDK1(2), PIK3CA(6), PITX2(4), PLCG2(22), PPP1R13B(6), PREX1(7), PTEN(18), PTPRC(26), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(12), TEC(9), VAV1(13)	18134775	286	138	255	137	164	16	19	32	55	0	0.0630	1.000	1.000
183	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(10), ADCY4(4), ADCY6(5), ADCY8(40), CACNA1A(25), CACNA1B(21), GNAS(17), GNAT3(2), GNB3(5), GRM4(14), ITPR3(6), KCNB1(30), PDE1A(32), PLCB2(6), PRKACA(3), PRKACB(4), PRKACG(7), PRKX(3), SCNN1A(6), SCNN1B(11), SCNN1G(21), TAS1R1(10), TAS1R2(20), TAS1R3(1), TAS2R1(7), TAS2R10(6), TAS2R13(2), TAS2R14(1), TAS2R16(8), TAS2R3(1), TAS2R38(13), TAS2R39(8), TAS2R4(3), TAS2R40(2), TAS2R41(11), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R60(15), TAS2R7(3), TAS2R8(3), TAS2R9(5), TRPM5(11)	18644034	410	137	388	327	271	33	18	51	37	0	0.887	1.000	1.000
184	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH7A1(8), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), G6PC2(3), GALM(2), GAPDH(1), GAPDHS(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(22), PGM1(4), PGM3(1), PKLR(8), PKM2(3)	19194694	323	135	292	150	218	29	18	37	21	0	0.00209	1.000	1.000
185	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(4), BAX(3), BTK(15), CAD(12), CASP10(2), CASP3(2), CASP8(7), CASP8AP2(7), CDK2AP1(1), CSNK1A1(2), DAXX(8), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EGFR(17), EPHB2(21), FAF1(7), FAIM2(4), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAP3K5(15), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MET(19), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(3), PTPN13(11), RALBP1(2), RIPK1(1), ROCK1(4), SMPD1(3), TNFRSF6B(2), TP53(37), TPX2(5), TRAF2(1), TUFM(4)	23931677	305	135	292	147	167	21	21	46	50	0	0.391	1.000	1.000
186	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(15), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), AOX1(18), CARM1(6), COMT(3), DBH(13), DCT(2), DDC(12), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(3), GOT2(4), HEMK1(4), HGD(10), HPD(4), LCMT1(3), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), MYST3(12), MYST4(9), NAT6(1), PNMT(2), PNPLA3(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(12), TH(7), TPO(33), TYR(7), TYRP1(8), WBSCR22(1)	19582692	370	133	351	190	258	33	20	39	20	0	0.138	1.000	1.000
187	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(1), ARHGAP1(2), ARHGAP4(1), ARHGEF11(15), BTK(15), CDC42(2), CFL1(1), GDI1(1), GDI2(2), INPPL1(14), ITPR1(21), ITPR2(15), ITPR3(6), LIMK1(2), MYLK(35), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3CG(21), PIK3R1(3), PITX2(4), PPP1R13B(6), PTEN(18), RACGAP1(3), RHO(1), ROCK1(4), ROCK2(13), SAG(9), WASF1(3), WASL(5)	23033988	334	133	315	138	204	27	14	50	38	1	0.00325	1.000	1.000
188	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(7), AGT(5), AGTR1(9), AGTR2(10), CMA1(5), COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), REN(8)	8315500	302	132	286	86	242	16	8	24	12	0	0.370	1.000	1.000
189	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(4), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(11), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), CYP4A11(19), CYP4A22(16), DCI(2), ECHS1(1), EHHADH(5), GCDH(5), HADHA(8), HADHB(3), HSD17B10(2), HSD17B4(6), PECI(1)	16232626	310	132	287	131	215	27	18	27	23	0	0.00316	1.000	1.000
190	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(6), ACTG1(6), ARHGEF2(17), ARPC5(1), CD14(4), CDC42(2), CDH1(4), CLDN1(5), CTNNB1(11), CTTN(1), EZR(1), FYN(5), HCLS1(5), ITGB1(4), KRT18(2), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(3), PRKCA(10), RHOA(1), ROCK1(4), ROCK2(13), TLR4(25), TLR5(16), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(12), WAS(6), WASL(5), YWHAQ(3)	17282293	287	131	277	112	180	32	11	34	30	0	0.000462	1.000	1.000
191	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(6), ACTG1(6), ARHGEF2(17), ARPC5(1), CD14(4), CDC42(2), CDH1(4), CLDN1(5), CTNNB1(11), CTTN(1), EZR(1), FYN(5), HCLS1(5), ITGB1(4), KRT18(2), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(3), PRKCA(10), RHOA(1), ROCK1(4), ROCK2(13), TLR4(25), TLR5(16), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(12), WAS(6), WASL(5), YWHAQ(3)	17282293	287	131	277	112	180	32	11	34	30	0	0.000462	1.000	1.000
192	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(2), CREBBP(17), CTBP2(1), DLL1(2), DLL3(4), DLL4(6), DTX1(8), DTX2(3), DTX3(4), DTX3L(5), DTX4(4), DVL1(1), DVL2(4), DVL3(6), EP300(13), HDAC1(1), HDAC2(1), HES1(2), JAG1(8), JAG2(7), LFNG(3), MAML1(3), MAML2(6), MAML3(6), MFNG(7), NCOR2(22), NCSTN(4), NOTCH1(5), NOTCH2(34), NOTCH3(21), NOTCH4(48), NUMB(4), NUMBL(3), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(3), RBPJL(3), SNW1(2)	22644022	280	130	276	139	160	26	12	60	22	0	0.619	1.000	1.000
193	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(2), ACP5(3), ACPP(6), ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), CYP19A1(9), CYP1A1(8), CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2D6(1), CYP2E1(12), CYP2F1(9), CYP2J2(3), CYP3A4(16), CYP3A5(10), CYP3A7(12), CYP4B1(17), CYP4F8(11), PON1(10)	9583676	329	129	306	182	255	20	11	18	25	0	0.00512	1.000	1.000
194	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), CEL(11), DGAT1(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), GK(6), GLA(1), GLB1(7), LCT(29), LIPC(8), LIPF(14), LIPG(5), LPL(3), PNLIP(3), PNLIPRP1(7), PNLIPRP2(2), PPAP2B(5), PPAP2C(6)	15923554	328	129	303	157	229	32	13	37	17	0	0.0193	1.000	1.000
195	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(15), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADIPOQ(3), ADIPOR1(4), ADIPOR2(1), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(2), CAMKK2(6), CD36(4), CHUK(2), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), G6PC(4), G6PC2(3), IKBKB(3), IRS1(5), IRS2(2), IRS4(9), JAK1(5), JAK2(7), JAK3(4), LEP(2), LEPR(19), MAPK10(8), MAPK8(1), MAPK9(5), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(16), PCK2(4), POMC(1), PPARA(6), PPARGC1A(12), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKCQ(13), PTPN11(9), RELA(4), RXRA(4), RXRB(4), RXRG(4), SLC2A1(4), SLC2A4(7), SOCS3(2), STAT3(10), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1), TYK2(7)	27377337	378	129	368	212	225	38	21	47	47	0	0.645	1.000	1.000
196	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(5), CAD(12), CANT1(9), CDA(1), CTPS(2), CTPS2(3), DCTD(2), DHODH(2), DPYD(53), DPYS(21), ENTPD1(7), ENTPD3(5), ENTPD4(3), ENTPD5(1), ENTPD6(4), ENTPD8(2), NME6(2), NME7(4), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(12), RRM1(3), RRM2(2), RRM2B(2), TK2(1), TXNRD1(4), TXNRD2(3), TYMS(1), UCK1(1), UMPS(1), UPB1(6), UPP2(2), UPRT(1)	26729841	319	127	302	163	203	24	17	49	26	0	0.331	1.000	1.000
197	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(2), AGT(5), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(2), CAMK1G(6), CAMK4(8), CREBBP(17), CSNK1A1(2), EDN1(7), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(2), GSK3B(2), HAND1(2), HAND2(5), HRAS(3), IGF1(9), LIF(2), MAP2K1(11), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(72), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NKX2-5(1), NPPA(2), PIK3CA(6), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RAF1(7), RPS6KB1(2), SYT1(17)	16757309	298	127	278	159	202	25	15	32	23	1	0.441	1.000	1.000
198	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(3), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(3), CHRNA1(5), FLT1(28), FLT4(17), KDR(32), NOS3(14), PDE2A(11), PDE3A(17), PDE3B(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKG1(10), PRKG2(13), RYR2(77), SLC7A1(3), SYT1(17)	13428312	289	127	274	173	198	22	9	31	29	0	0.544	1.000	1.000
199	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(17), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(2), CTNNB1(11), DVL1(1), DVL2(4), DVL3(6), FBXW2(1), FZD1(4), FZD10(1), FZD2(5), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LDLR(10), MAPK10(8), MAPK9(5), MYC(4), PAFAH1B1(4), PLAU(1), PPP2R5C(4), PPP2R5E(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), PRKD1(3), RAC1(16), RHOA(1), SFRP4(6), TCF7(1), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4)	19637277	269	127	256	138	166	28	8	32	35	0	0.171	1.000	1.000
200	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(2), BMP5(21), BMP6(7), BMP7(1), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1A1L(5), CSNK1D(1), CSNK1E(2), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(4), GLI1(9), GLI2(32), GLI3(15), GSK3B(2), HHIP(17), IHH(2), LRP2(68), PRKACA(3), PRKACB(4), PRKACG(7), PRKX(3), PTCH1(7), PTCH2(15), RAB23(1), SHH(4), SMO(10), STK36(12), SUFU(2), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3), ZIC2(2)	19851691	358	125	343	170	240	32	18	37	31	0	0.0280	1.000	1.000
201	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(10), BLNK(8), BTK(15), CD19(7), CD22(17), CR2(26), CSK(1), DAG1(5), FLOT1(2), GRB2(1), GSK3B(2), INPP5D(24), ITPR1(21), ITPR2(15), ITPR3(6), LYN(5), MAP4K1(8), MAPK1(4), MAPK3(1), NFATC1(13), NFATC2(6), NR0B2(3), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PLCG2(22), PPP1R13B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(26), RAF1(7), SHC1(1), SOS1(7), SOS2(11), SYK(12), VAV1(13)	24341275	351	125	343	161	222	24	24	43	37	1	0.0203	1.000	1.000
202	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(8), PKM2(3)	16111702	273	124	248	120	188	27	14	28	16	0	0.000822	1.000	1.000
203	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(8), PKM2(3)	16111702	273	124	248	120	188	27	14	28	16	0	0.000822	1.000	1.000
204	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(1), ALAS2(5), BLVRA(2), COX10(4), COX15(4), CP(9), CPOX(2), EPRS(9), FECH(3), FTH1(3), FTMT(5), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(1), PPOX(2), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), UROS(1)	13884039	298	124	281	118	200	24	18	19	36	1	0.00150	1.000	1.000
205	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(5), CALR(1), CANX(1), CD4(6), CD74(5), CD8A(2), CD8B(5), CIITA(14), CTSL1(1), CTSS(6), HLA-A(3), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(5), HLA-G(2), HSP90AA1(2), HSP90AB1(5), HSPA5(4), IFI30(2), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), KIR2DL1(17), KIR2DL3(6), KIR2DL4(3), KIR2DS4(13), KIR3DL1(12), KIR3DL2(2), KIR3DL3(6), KLRC1(3), KLRC2(1), KLRC3(11), KLRC4(4), KLRD1(3), LGMN(5), LTA(1), NFYA(1), NFYB(3), NFYC(1), PDIA3(3), PSME2(3), RFX5(5), RFXANK(1), RFXAP(1), TAP1(1), TAP2(11), TAPBP(1)	15146629	276	124	268	142	178	27	12	34	25	0	0.127	1.000	1.000
206	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(8), AKT3(4), BRD4(14), CAP1(1), CBL(8), CDC42(2), CDKN2A(31), F2RL2(5), FLOT1(2), GRB2(1), GSK3B(2), IGFBP1(3), INPPL1(14), IRS1(5), IRS2(2), IRS4(9), LNPEP(9), MAPK1(4), MAPK3(1), PARD3(14), PARD6A(1), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PPYR1(10), PTEN(18), PTPN1(4), RAF1(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(1), SLC2A4(7), SORBS1(10), SOS1(7), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	19681488	263	124	244	102	125	25	16	42	54	1	0.0571	1.000	1.000
207	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(4), CDC42(2), DLD(2), DUSP10(5), DUSP8(3), GAB1(2), GCK(15), IL1R1(10), JUN(1), MAP2K4(4), MAP2K5(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K7(1), MAP3K9(20), MAPK10(8), MAPK7(3), MAPK8(1), MAPK9(5), MYEF2(4), NFATC3(7), NR2C2(2), PAPPA(44), SHC1(1), TP53(37), TRAF6(4), ZAK(6)	16579825	268	124	255	102	174	20	11	30	33	0	0.0415	1.000	1.000
208	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), P4HB(2), SLC23A1(2), SLC23A2(4), SLC2A1(4), SLC2A3(7)	8219316	277	122	263	73	223	14	9	20	11	0	0.0938	1.000	1.000
209	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ACTG2(3), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(1), CDC42(2), CFL1(1), FLNA(14), FLNC(47), FSCN1(4), FSCN2(2), FSCN3(8), GDI1(1), GDI2(2), LIMK1(2), MYH2(72), MYLK(35), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), RHO(1), ROCK1(4), ROCK2(13), VASP(3), WASF1(3), WASL(5)	15719931	313	121	291	162	210	40	9	32	22	0	0.0326	1.000	1.000
210	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(7), ADAM17(1), ATP6AP1(1), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(17), F11R(4), GIT1(3), HBEGF(1), IGSF5(7), IKBKB(3), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(5), MAP2K4(4), MAP3K14(3), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK8(1), MAPK9(5), MET(19), NFKB1(7), NFKB2(4), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(7), PLCG2(22), PTPN11(9), PTPRZ1(19), RAC1(16), RELA(4), SRC(1), TCIRG1(3), TJP1(9)	23225189	305	120	293	170	189	27	16	48	25	0	0.656	1.000	1.000
211	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(5), BAX(3), BCL2(2), BCL2L11(5), BIRC2(3), BIRC3(6), BIRC5(1), BNIP3L(2), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(12), GZMB(2), HELLS(5), IKBKB(3), IRF1(1), IRF2(5), IRF3(3), IRF4(3), IRF5(4), IRF6(11), IRF7(7), JUN(1), LTA(1), MAP2K4(4), MAP3K1(2), MAPK10(8), MDM2(3), MYC(4), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(9), PRF1(7), RELA(4), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(8), TNFRSF25(4), TNFSF10(7), TP53(37), TP73(5), TRAF1(5), TRAF2(1), TRAF3(5)	18844791	249	119	241	112	150	23	17	26	33	0	0.112	1.000	1.000
212	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(7), ALOX12(5), ALOX12B(11), ALOX15(8), ALOX15B(8), ALOX5(7), CBR3(1), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2J2(3), CYP2U1(1), CYP4A11(19), CYP4A22(16), CYP4F2(11), CYP4F3(15), EPHX2(4), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GPX6(15), LTA4H(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PTGDS(1), PTGES2(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9)	12737054	377	119	357	227	298	24	6	21	28	0	0.0667	1.000	1.000
213	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(15), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), AOX1(18), COMT(3), DBH(13), DCT(2), DDC(12), FAH(2), GOT1(3), GOT2(4), HGD(10), HPD(4), MAOA(2), MAOB(11), PNMT(2), TAT(12), TH(7), TPO(33), TYR(7)	10415268	285	119	266	142	212	23	15	21	14	0	0.0120	1.000	1.000
214	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), ELK1(2), FPR1(15), GNA15(5), HRAS(3), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(39), PLCB1(45), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAC1(16), RAF1(7), RELA(4), SYT1(17)	12545826	267	118	237	101	189	13	9	29	27	0	0.00237	1.000	1.000
215	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), XYLB(4)	8962706	246	118	230	105	170	19	14	15	27	1	0.0155	1.000	1.000
216	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(4), AKT1(3), APC(17), CAMP(1), DAG1(5), DLG4(4), EPHB2(21), GNAI1(1), GNAQ(4), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RAC1(16), RHO(1), RYR1(72)	15001466	231	118	216	132	159	20	12	19	21	0	0.181	1.000	1.000
217	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(8), CD28(1), CD3D(4), CSK(1), CTLA4(2), DAG1(5), EPHB2(21), FBXW7(10), GRAP2(4), GRB2(1), ITK(19), ITPKB(5), LAT(1), LCK(10), LCP2(9), MAPK1(4), NCK1(1), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PLCG1(7), PTPRC(26), RAF1(7), RASGRP1(6), RASGRP2(6), RASGRP3(11), RASGRP4(9), SOS1(7), SOS2(11), VAV1(13), ZAP70(4)	18261628	308	118	295	140	190	27	17	42	32	0	0.0787	1.000	1.000
218	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPPL1(14), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3CA(6), PIK3CB(21), PIK3CG(21), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCG1(7), PLCG2(22)	14699678	287	117	264	122	192	14	12	39	29	1	0.00947	1.000	1.000
219	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(8), AKT3(4), BCR(10), BLNK(8), BTK(15), CD19(7), CSK(1), DAG1(5), EPHB2(21), GRB2(1), ITPKB(5), LYN(5), MAP2K1(11), MAP2K2(3), MAPK1(4), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(5), PIK3CA(6), PIK3CD(7), PIK3R1(3), PLCG2(22), PPP1R13B(6), RAF1(7), SERPINA4(12), SHC1(1), SOS1(7), SOS2(11), SYK(12), VAV1(13)	17415013	250	117	239	125	150	20	15	39	25	1	0.288	1.000	1.000
220	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(1), ABP1(15), ACAT2(1), ACMSD(9), AFMID(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(18), ASMT(5), CARM1(6), CAT(5), CYP1A1(8), CYP1A2(10), CYP1B1(2), DDC(12), ECHS1(1), EHHADH(5), GCDH(5), HAAO(3), HADHA(8), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(8), KMO(7), KYNU(10), LCMT1(3), LNX1(13), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), NFX1(5), OGDH(10), OGDHL(31), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(4), TPH1(5), TPH2(11), WARS(4), WARS2(4), WBSCR22(1)	19949334	334	116	323	165	226	27	18	42	21	0	0.0687	1.000	1.000
221	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(38), B3GALT4(2), CDR1(11), DGKI(21), IL6ST(10), MRPL19(1), PIGK(5), RPL10(4), RPL11(2), RPL13A(1), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(4), RPL5(5), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS27(1), RPS29(1), RPS3A(1), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(5), TBC1D10C(5), TSPAN9(3), UBB(1), UBC(4)	17108004	207	115	197	119	123	19	13	32	20	0	0.747	1.000	1.000
222	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(15), AGMAT(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH4A1(5), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(5), CKM(2), CKMT2(4), CPS1(17), DAO(9), GAMT(3), GATM(4), GLUD1(1), GOT1(3), GOT2(4), MAOA(2), MAOB(11), NOS1(48), NOS3(14), OAT(2), ODC1(3), OTC(2), P4HA1(8), P4HA2(4), P4HA3(10), P4HB(2), PYCR1(1), RARS(7), SMS(5)	14511719	242	114	236	142	154	28	13	22	25	0	0.438	1.000	1.000
223	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(7), F11(9), F12(1), F13B(19), F2(9), F5(24), F7(7), F8(40), F9(11), FGA(32), FGB(6), FGG(7), LPA(41), PLAT(3), PLAU(1), PLG(25), SERPINB2(16), SERPINE1(5), SERPINF2(5), VWF(40)	11571113	308	114	297	120	218	20	19	23	27	1	0.00854	1.000	1.000
224	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44), C8A(29), C8B(34), C9(16), MASP1(6)	6792813	261	114	230	106	193	14	8	27	19	0	0.00422	1.000	1.000
225	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(4), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), NOS1(48), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), SYT1(17)	8389358	242	113	226	155	175	26	5	17	19	0	0.415	1.000	1.000
226	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(11), BMPR1B(3), CCND2(3), CDK4(5), CDKN1B(1), DAZL(4), DMC1(8), EGR1(4), ESR2(6), FSHR(13), GJA4(4), INHA(4), LHCGR(21), MLH1(5), MSH5(12), NCOR1(17), NR5A1(5), NRIP1(6), PGR(12), PRLR(24), PTGER2(6), SMPD1(3), VDR(2), ZP2(7)	11502202	186	112	171	97	124	15	4	24	19	0	0.662	1.000	1.000
227	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(7), ABP1(15), ACADL(4), ACADM(5), ACADSB(4), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(7), DPYD(53), DPYS(21), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), MLYCD(1), SDS(2), SMS(5), UPB1(6)	9595855	210	111	197	103	136	19	11	30	14	0	0.168	1.000	1.000
228	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44), C8A(29), C9(16), MASP1(6), MASP2(6), MBL2(10)	6962343	243	111	216	100	180	12	5	25	21	0	0.00730	1.000	1.000
229	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), CRK(2), CRKL(2), DOCK1(12), ELK1(2), FOS(2), GAB1(2), GRB2(1), HGF(22), HRAS(3), ITGA1(16), ITGB1(4), JUN(1), MAP2K1(11), MAP2K2(3), MAP4K1(8), MAPK1(4), MAPK3(1), MAPK8(1), MET(19), PAK1(4), PIK3CA(6), PIK3R1(3), PTEN(18), PTK2(8), PTK2B(8), PTPN11(9), PXN(3), RAF1(7), RAP1A(2), RAP1B(1), RASA1(4), SOS1(7), SRC(1), STAT3(10)	14398668	209	111	197	91	113	16	10	37	32	1	0.501	1.000	1.000
230	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(9), ALDOC(3), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GAPDHS(1), GCK(15), GOT1(3), GOT2(4), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(3), PC(12), PCK1(16), PDHA1(2), PDHA2(15), PDHB(1), PDHX(2), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(22), PKLR(8), PKM2(3), TNFAIP1(1)	14031082	205	110	193	104	142	17	12	19	15	0	0.0197	1.000	1.000
231	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(5), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(1), GALNT12(6), GALNT13(23), GALNT14(23), GALNT2(5), GALNT3(3), GALNT4(3), GALNT5(8), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GALNTL1(4), GALNTL2(17), GALNTL4(6), GALNTL5(12), GCNT1(6), GCNT3(5), GCNT4(4), OGT(9), ST3GAL1(5), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(36)	10652859	238	110	224	109	177	10	6	23	22	0	0.0824	1.000	1.000
232	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(36), C5(9), C6(50), C7(44), ICAM1(1), IL1A(4), IL6(2), IL8(1), ITGA4(29), ITGAL(19), ITGB1(4), ITGB2(10), SELP(28), SELPLG(8), TNF(1), VCAM1(13)	8118657	259	110	235	104	184	9	13	24	29	0	0.00228	1.000	1.000
233	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(3), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), CDS1(6), CDS2(4), CHAT(13), CHKA(2), CHKB(1), CHPT1(1), CRLS1(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), ESCO1(1), ESCO2(2), ETNK1(4), GNPAT(2), GPAM(2), GPD1(6), GPD1L(2), GPD2(2), LYPLA1(1), MYST3(12), MYST4(9), NAT6(1), PCYT1A(3), PCYT1B(6), PEMT(2), PISD(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLD1(9), PLD2(5), PNPLA3(2), PPAP2B(5), PPAP2C(6), PTDSS2(1), SH3GLB1(2)	21532695	269	109	259	157	162	26	8	41	32	0	0.820	1.000	1.000
234	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(3), AKT2(8), AKT3(4), BTK(15), CDKN2A(31), DAPP1(4), GRB2(1), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(24), PDK1(2), PIK3CA(6), PPP1R13B(6), PTEN(18), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SOS1(7), SOS2(11), TEC(9), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	11884683	187	109	164	52	93	9	14	25	46	0	0.00134	1.000	1.000
235	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(4), G6PC2(3), GAA(6), GALK1(1), GALK2(2), GALT(2), GANC(5), GCK(15), GLA(1), GLB1(7), HK1(3), HK2(11), HK3(12), HSD3B7(3), LALBA(6), LCT(29), MGAM(124), PFKL(4), PFKM(1), PGM1(4), PGM3(1), RDH11(2), RDH12(2), RDH13(3), UGP2(1)	12703662	266	108	253	150	192	24	7	28	15	0	0.150	1.000	1.000
236	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1B10(8), AKR1C4(7), AKR1D1(17), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), BAAT(9), CEL(11), CYP27A1(3), CYP7A1(6), HADHB(3), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(6), SOAT1(3), SOAT2(4), SRD5A1(2), SRD5A2(5)	10484346	234	108	212	110	152	27	19	22	14	0	0.0242	1.000	1.000
237	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(7), ABP1(15), ACADM(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(7), DPYD(53), DPYS(21), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HIBCH(1), MLYCD(1), SMS(5), UPB1(6)	8925225	197	108	183	100	125	19	12	28	13	0	0.243	1.000	1.000
238	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(8), ALOX15(8), ALOX5(7), CYP1A2(10), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2J2(3), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), HSD3B7(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), RDH11(2), RDH12(2), RDH13(3)	7869382	266	108	250	150	208	11	8	14	25	0	0.0680	1.000	1.000
239	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(12), CANT1(9), CDA(1), CTPS(2), CTPS2(3), DCTD(2), DHODH(2), DPYD(53), DPYS(21), ENTPD1(7), NT5E(3), NT5M(1), POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(4), TYMS(1), UCK1(1), UMPS(1), UNG(2), UPB1(6)	18923449	232	108	216	100	148	16	11	36	21	0	0.0278	1.000	1.000
240	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44), C8A(29), C9(16)	5705367	221	107	194	86	163	10	5	24	19	0	0.00452	1.000	1.000
241	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(15), CALM1(1), CALM2(1), ELK1(2), FCER1A(12), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PAK2(8), PIK3CA(6), PIK3R1(3), PLA2G4A(10), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(7), SHC1(1), SOS1(7), SYK(12), SYT1(17), VAV1(13)	14147534	209	107	198	94	133	11	12	33	19	1	0.354	1.000	1.000
242	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(7), AKR1D1(17), ARSB(1), ARSD(3), ARSE(5), CYP11B1(11), CYP11B2(11), HSD11B1(10), HSD11B2(2), HSD17B2(7), HSD17B3(3), HSD3B1(10), HSD3B2(7), SRD5A1(2), SRD5A2(5), STS(6), SULT1E1(10), SULT2A1(6), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27)	8980020	239	106	223	111	159	26	16	14	23	1	0.00917	1.000	1.000
243	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CDK5(4), F2(9), FYN(5), GNA11(6), GNAI1(1), GRB2(1), HRAS(3), JAK2(7), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPT(9), MYLK(35), PLCG1(7), PRKCA(10), PTK2B(8), RAF1(7), SHC1(1), SOS1(7), STAT1(3), STAT3(10), STAT5A(2), SYT1(17)	13666459	210	106	194	114	125	20	10	33	22	0	0.557	1.000	1.000
244	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(4), GAA(6), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(15), GLA(1), GLB1(7), HK1(3), HK2(11), HK3(12), LALBA(6), LCT(29), MGAM(124), PFKM(1), PGM1(4), PGM3(1)	10712335	240	106	227	132	173	24	7	24	12	0	0.119	1.000	1.000
245	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(3), CDS1(6), CDS2(4), CHAT(13), CHKA(2), CHKB(1), CLC(2), CPT1B(10), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), ETNK1(4), GNPAT(2), GPD1(6), GPD2(2), LGALS13(3), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(6), PEMT(2), PISD(1), PLA2G1B(1), PLA2G2A(2), PLA2G2E(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB2(6), PLCG1(7), PLCG2(22), PPAP2B(5), PPAP2C(6)	16466078	248	106	240	130	163	18	7	36	24	0	0.145	1.000	1.000
246	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(4), ARHGEF11(15), BCL2(2), CDC42(2), DLG4(4), GNA13(1), LPA(41), MAP2K4(4), MAP3K1(2), MAP3K5(15), MAPK8(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(5), PIK3CB(21), PLD1(9), PLD2(5), PLD3(1), PTK2(8), RDX(1), ROCK1(4), ROCK2(13), SERPINA4(12), SRF(3), TBXA2R(4)	16163640	218	106	209	106	116	18	10	45	29	0	0.520	1.000	1.000
247	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(1), CD3D(4), CD3G(1), ELK1(2), FOS(2), FYN(5), GRB2(1), HRAS(3), JUN(1), LAT(1), LCK(10), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKBIA(2), PIK3CA(6), PIK3R1(3), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), PTPN7(1), RAC1(16), RAF1(7), RASA1(4), RELA(4), SHC1(1), SOS1(7), SYT1(17), VAV1(13), ZAP70(4)	15723112	208	106	190	87	133	18	8	31	17	1	0.150	1.000	1.000
248	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(5), ABO(4), B3GALNT1(5), B3GALT1(9), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(1), B3GNT3(5), B3GNT4(3), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(4), FUT6(4), FUT7(2), FUT9(22), GBGT1(1), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(7), PIGH(1), PIGK(5), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(7), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(6), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(6), UGCG(1)	15952285	200	105	197	100	115	22	12	31	20	0	0.130	1.000	1.000
249	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(8), CFL1(1), GNAQ(4), GNAS(17), HRAS(3), LIMK1(2), MAP2K1(11), MAPK1(4), MAPK3(1), MYL2(4), NOX1(10), PIK3C2G(39), PLCB1(45), PPP1R12B(7), PRKCA(10), PTK2(8), RAF1(7), ROCK2(13)	8255848	195	104	178	71	136	6	5	31	17	0	0.0172	1.000	1.000
250	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(4), ANKRD6(2), APC(17), AXIN1(9), AXIN2(3), CER1(12), CSNK1A1(2), CTNNB1(11), DACT1(9), DKK1(2), DKK2(12), DKK3(4), DKK4(2), DVL1(1), FSTL1(2), GSK3B(2), LRP1(28), MVP(8), NKD1(6), NKD2(5), PIN1(1), PSEN1(1), PTPRA(6), SENP2(10), SFRP1(2), TSHB(5), WIF1(7)	13169699	184	104	181	93	104	21	8	26	25	0	0.471	1.000	1.000
251	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1C4(7), AKR1D1(17), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BAAT(9), CEL(11), CYP27A1(3), CYP7A1(6), HADHB(3), SOAT2(4), SRD5A1(2), SRD5A2(5)	7699701	202	103	182	86	133	22	14	21	12	0	0.00828	1.000	1.000
252	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(8), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), BBOX1(3), DOT1L(7), ECHS1(1), EHHADH(5), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(14), OGDH(10), OGDHL(31), PIPOX(5), PLOD1(5), PLOD2(5), PLOD3(4), RDH11(2), RDH12(2), RDH13(3), SETD1A(22), SETD7(2), SETDB1(10), SHMT1(1), SHMT2(2), SUV39H1(1), SUV39H2(1), TMLHE(1)	19071286	224	102	215	102	140	20	15	33	16	0	0.0935	1.000	1.000
253	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(1), CD36(4), CPT1B(10), CREBBP(17), EHHADH(5), EP300(13), FABP1(6), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(17), MYC(4), NCOA1(7), NCOR1(17), NCOR2(22), NFKBIA(2), NR0B2(3), NR1H3(2), NR2F1(6), NRIP1(6), PDGFA(1), PIK3CA(6), PIK3R1(3), PPARA(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PTGS2(9), RB1(8), RELA(4), RXRA(4), SP1(3), STAT5A(2), STAT5B(4), TNF(1)	20921014	244	102	238	109	154	19	17	31	20	3	0.154	1.000	1.000
254	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(48), GABBR1(6), GPRC5A(4), GPRC5B(5), GPRC5C(7), GPRC5D(2), GRM1(14), GRM2(5), GRM3(45), GRM4(14), GRM5(10), GRM7(28), GRM8(41)	6886701	229	101	214	151	166	18	12	19	14	0	0.113	1.000	1.000
255	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(5), AADAC(13), ABAT(7), ACADS(4), ACAT2(1), ACSM1(22), AKR1B10(8), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH5A1(8), ALDH7A1(8), ALDH9A1(2), BDH1(3), DDHD1(6), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HMGCL(3), HMGCS1(1), HMGCS2(16), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(3), L2HGDH(3), OXCT1(4), OXCT2(2), PDHA1(2), PDHA2(15), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3)	13417181	220	101	211	108	144	24	13	21	18	0	0.116	1.000	1.000
256	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(8), BTK(15), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP3K1(2), MAPK14(5), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), RAC1(16), RAF1(7), SHC1(1), SOS1(7), SYK(12), SYT1(17), VAV1(13)	12600346	200	100	181	84	133	9	10	30	18	0	0.130	1.000	1.000
257	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(18), ACACB(15), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PC(12), PCK1(16), PCK2(4), PDHA1(2), PDHA2(15), PDHB(1), PKLR(8), PKM2(3)	15459865	204	100	197	109	127	17	15	31	14	0	0.338	1.000	1.000
258	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(4), BCR(10), BLNK(8), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8IP3(8), PAPPA(44), RAC1(16), RPS6KA1(6), RPS6KA3(2), SHC1(1), SOS1(7), SYK(12), VAV1(13), VAV2(2), VAV3(8)	10488642	173	100	154	100	124	11	3	21	14	0	0.726	1.000	1.000
259	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(15), AGXT(7), AGXT2(16), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(4), CBS(6), CHDH(5), CHKA(2), CHKB(1), CPT1B(10), CTH(1), DAO(9), DLD(2), DMGDH(8), GAMT(3), GARS(5), GATM(4), GCAT(4), GLDC(4), MAOA(2), MAOB(11), PEMT(2), PISD(1), PLCB2(6), PLCG1(7), PLCG2(22), PSPH(2), SARDH(16), SARS(10), SHMT1(1), SHMT2(2), TARS(1)	13878751	211	99	205	114	142	14	12	23	20	0	0.172	1.000	1.000
260	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(6), APAF1(5), ARHGDIB(3), BAG4(3), BCL2(2), BIRC2(3), BIRC3(6), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(8), DFFA(2), DFFB(3), GSN(3), LMNA(8), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(15), MAPK8(1), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(16), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(4), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF1(5), TRAF2(1)	22825930	202	99	199	90	94	23	14	44	25	2	0.290	1.000	1.000
261	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(4), ADRB2(2), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), HRH1(9), HRH2(2), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8)	8300971	195	99	182	148	124	21	8	25	17	0	0.149	1.000	1.000
262	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(1), DAG1(5), DGKA(3), ETFA(2), GCA(2), ITGA9(8), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), MAP2K1(11), MAPK1(4), MAPK3(1), NR1I3(6), PAK1(4), PDE3A(17), PDE3B(6), PI3(5), PIK3C2G(39), PIK3CA(6), PIK3CD(7), PIK3R1(3), RIPK3(8), VASP(3)	15979795	195	99	181	71	127	14	10	23	20	1	0.000576	1.000	1.000
263	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(16), ATP4A(12), ATP4B(1), ATP5B(1), ATP5C1(2), ATP5F1(5), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), COX10(4), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(3), NDUFA12(1), NDUFA13(6), NDUFA4(1), NDUFA6(1), NDUFA9(1), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFS3(2), NDUFS4(2), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(2), UQCRFS1(2)	18505279	200	98	196	85	117	16	14	34	19	0	0.0360	1.000	1.000
264	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(15), AGXT(7), AGXT2(16), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(4), CBS(6), CHDH(5), CHKA(2), CHKB(1), CTH(1), DAO(9), DLD(2), DMGDH(8), GAMT(3), GARS(5), GATM(4), GCAT(4), GLDC(4), GNMT(1), HSD3B7(3), MAOA(2), MAOB(11), PEMT(2), PHGDH(12), PIPOX(5), PISD(1), PSAT1(1), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(16), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(7)	14107189	215	98	205	116	140	14	10	25	26	0	0.252	1.000	1.000
265	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(15), ACY3(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH7A1(8), ALDH9A1(2), AMDHD1(3), AOC2(7), AOC3(8), ASPA(3), CARM1(6), CNDP1(7), DDC(12), FTCD(2), HAL(11), HARS(7), HARS2(3), HDC(16), HEMK1(4), HNMT(1), LCMT1(3), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(3), UROC1(10), WBSCR22(1)	13031688	205	98	201	125	128	23	13	22	19	0	0.539	1.000	1.000
266	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(7), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(28), FLT4(17), HIF1A(5), HRAS(3), KDR(32), NOS3(14), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTK2(8), PXN(3), SHC1(1), VHL(4)	11265656	165	98	154	86	100	13	3	25	23	1	0.585	1.000	1.000
267	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(36), C5(9), C6(50), C7(44), C8A(29), C9(16)	4101353	184	97	161	65	139	6	4	17	18	0	0.00265	1.000	1.000
268	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(2), ABAT(7), ACY3(2), ADSL(3), ADSS(2), ADSSL1(7), AGXT(7), AGXT2(16), ASL(5), ASNS(8), ASPA(3), ASRGL1(2), ASS1(6), CAD(12), CRAT(5), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(12), GAD2(7), GOT1(3), GOT2(4), GPT(3), GPT2(1), NARS(2), NARS2(4), PC(12), PDHA1(2), PDHA2(15), PDHB(1)	12519163	175	97	166	83	119	16	9	20	11	0	0.0712	1.000	1.000
269	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(2), DAXX(8), EGF(14), EGFR(17), ETS1(3), ETS2(7), FOS(2), HOXA7(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(11), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(15), MAPK1(4), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), RAF1(7), RELA(4), RIPK1(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1)	16133073	213	97	204	125	131	19	9	35	19	0	0.843	1.000	1.000
270	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(5), BAX(3), BCL2(2), BIRC2(3), BIRC3(6), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), FAS(5), FASLG(12), GZMB(2), JUN(1), MAP2K4(4), MAP3K1(2), MAP3K14(3), MAPK10(8), MCL1(3), MDM2(3), MYC(4), NFKB1(7), NFKBIA(2), PARP1(6), PRF1(7), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TNFSF10(7), TP53(37), TRAF1(5), TRAF2(1)	12281794	166	96	160	57	88	14	15	20	29	0	0.0115	1.000	1.000
271	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(5), ARG1(1), ARG2(1), ASL(5), ASS1(6), CKM(2), CKMT2(4), CPS1(17), DAO(9), EPRS(9), GAMT(3), GATM(4), GLUD1(1), GLUD2(3), GOT1(3), GOT2(4), LAP3(1), NOS1(48), NOS3(14), OAT(2), OTC(2), P4HA1(8), P4HA2(4), P4HA3(10), PRODH(1), PYCR1(1), RARS(7), RARS2(2)	11807859	177	96	172	105	116	19	7	15	20	0	0.562	1.000	1.000
272	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), ASCC3(10), ATP13A2(8), DDX18(4), DDX19A(1), DDX23(5), DDX4(10), DDX41(5), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(2), DDX56(3), DHX58(4), ENTPD7(2), EP400(18), ERCC2(2), ERCC3(1), FPGS(2), GGH(2), IFIH1(13), MOV10L1(23), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(5), RUVBL2(4), SETX(13), SKIV2L2(5), SMARCA2(10), SMARCA5(5), SPR(2)	20580993	212	96	202	99	133	14	13	27	25	0	0.176	1.000	1.000
273	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(2), CARS(9), CARS2(2), DARS(4), DARS2(3), EPRS(9), FARS2(4), FARSA(6), FARSB(5), GARS(5), HARS(7), HARS2(3), IARS(8), IARS2(12), KARS(4), LARS(9), LARS2(2), MARS(5), MARS2(3), MTFMT(1), NARS(2), NARS2(4), QARS(5), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(1), TARS2(7), VARS(18), VARS2(5), WARS(4), WARS2(4), YARS(1), YARS2(2)	18075180	182	96	170	90	109	18	9	26	20	0	0.413	1.000	1.000
274	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(7), ALOX12(5), ALOX15(8), ALOX5(7), CBR3(1), CYP4F2(11), CYP4F3(15), EPX(5), GGT1(4), LPO(15), LTA4H(3), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(1), PTGES2(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9), TPO(33)	9191724	213	96	210	112	159	18	3	17	16	0	0.0193	1.000	1.000
275	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(4), CHUK(2), ELK1(2), FOS(2), IKBKB(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(4), NFKB1(7), NFKBIA(2), PPARA(6), RELA(4), TIRAP(1), TLR10(8), TLR2(13), TLR3(8), TLR4(25), TLR6(5), TLR7(15), TLR9(12), TOLLIP(1), TRAF6(4)	11951023	162	96	160	76	101	16	9	24	12	0	0.194	1.000	1.000
276	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(3), ARRB2(6), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CLCA1(3), CLCA2(7), CLCA4(17), CNGA3(22), CNGA4(11), CNGB1(17), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(6), PDC(5), PDE1C(37), PRKACA(3), PRKACB(4), PRKACG(7), PRKG1(10), PRKG2(13), PRKX(3)	9944606	208	95	197	119	142	14	6	28	18	0	0.393	1.000	1.000
277	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(21), AR(3), ESR1(5), ESR2(6), ESRRA(2), HNF4A(13), NPM1(3), NR0B1(1), NR1D2(9), NR1H2(3), NR1H3(2), NR1I2(2), NR1I3(6), NR2C2(2), NR2E1(3), NR2F1(6), NR2F2(1), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(2), NR5A1(5), NR5A2(16), PGR(12), PPARA(6), PPARD(2), PPARG(11), RARA(3), RARB(4), RARG(1), ROR1(10), RORA(3), RORC(6), RXRA(4), RXRB(4), RXRG(4), THRA(2), THRB(12), VDR(2)	13734019	206	95	199	102	149	13	4	22	18	0	0.0945	1.000	1.000
278	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(4), CFL1(1), CHN1(5), LIMK1(2), MAP3K1(2), MYL2(4), MYLK(35), NCF2(7), PAK1(4), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLD1(9), PPP1R12B(7), RAC1(16), RALBP1(2), RPS6KB1(2), TRIO(15), VAV1(13), WASF1(3)	11557271	164	95	152	88	108	8	9	23	15	1	0.648	1.000	1.000
279	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(7), ACAA1(5), ACAA2(1), ACADM(5), ACADS(4), ACAT2(1), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH7A1(8), ALDH9A1(2), AOX1(18), AUH(3), BCAT1(11), BCAT2(1), BCKDHA(1), BCKDHB(2), DLD(2), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), HIBADH(7), HIBCH(1), HMGCL(3), HMGCS1(1), HMGCS2(16), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(3), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), OXCT2(2), PCCA(3), PCCB(2)	14257130	172	94	165	88	100	19	12	29	12	0	0.619	1.000	1.000
280	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(5), ACTN2(16), ACTN3(7), BCAR1(4), BCR(10), CAPN1(4), CAPNS1(1), CAV1(1), CRKL(2), CSK(1), FYN(5), GRB2(1), HRAS(3), ITGA1(16), ITGB1(4), JUN(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MAPK8(1), PPP1R12B(7), PTK2(8), PXN(3), RAF1(7), RAP1A(2), ROCK1(4), SHC1(1), SOS1(7), SRC(1), TLN1(11), VCL(7), ZYX(6)	15384738	167	94	159	76	89	20	8	29	20	1	0.149	1.000	1.000
281	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(5), F2RL3(3), GNAI1(1), HRAS(3), ITGA1(16), ITGB1(4), MAP2K1(11), MAPK1(4), MAPK3(1), PLA2G4A(10), PLCB1(45), PRKCA(10), PTGS1(14), PTK2(8), RAF1(7), SRC(1), SYK(12), TBXAS1(9)	8028622	173	93	162	68	117	13	5	20	18	0	0.0170	1.000	1.000
282	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(5), AGTR1(9), ATF2(4), CALM1(1), CALM2(1), EGFR(17), ELK1(2), GNAQ(4), GRB2(1), HRAS(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), PAK1(4), PRKCA(10), PTK2(8), PTK2B(8), RAC1(16), RAF1(7), SHC1(1), SOS1(7), SRC(1), SYT1(17)	11019751	165	92	144	80	109	12	7	23	14	0	0.484	1.000	1.000
283	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(18), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(4), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PC(12), PCK1(16), PDHA1(2), PDHA2(15), PDHB(1), PKLR(8), PKM2(3)	12220662	164	92	159	93	108	14	10	23	9	0	0.602	1.000	1.000
284	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(15), DLG4(4), EPHB2(21), F2(9), F2RL1(14), F2RL2(5), F2RL3(3), JUN(1), MAP2K5(2), MAPK1(4), MAPK7(3), MAPK8(1), MYEF2(4), PLD1(9), PLD2(5), PLD3(1), PTK2(8), RAF1(7), RASAL1(13), SRC(1), TEC(9), VAV1(13)	9027412	152	92	145	96	83	16	6	32	15	0	0.901	1.000	1.000
285	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), AOX1(18), BCAT1(11), BCKDHA(1), BCKDHB(2), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), HIBADH(7), HMGCL(3), IVD(4), MCCC1(3), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), PCCA(3), PCCB(2), SDS(2)	11937056	145	92	140	76	88	14	8	23	12	0	0.654	1.000	1.000
286	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(11), ATR(18), BRCA1(8), CDC25A(7), CDC25B(4), CDC25C(2), CDC34(3), CDKN1A(4), CHEK1(1), CHEK2(2), EP300(13), MDM2(3), MYT1(19), PRKDC(16), RPS6KA1(6), TP53(37), WEE1(2), YWHAQ(3)	13889868	159	91	151	54	83	12	11	25	28	0	0.0827	1.000	1.000
287	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(3), ENPP7(6), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(7), LCT(29), NEU1(6), NEU2(10), NEU3(3), NEU4(8), PPAP2B(5), PPAP2C(6), SGMS1(12), SGMS2(1), SGPP2(5), SMPD1(3), SMPD2(1), SMPD3(6), SMPD4(4), SPHK1(1), SPHK2(6), SPTLC1(2), SPTLC2(5), UGCG(1), UGT8(6)	11676586	162	91	157	103	108	12	5	23	14	0	0.788	1.000	1.000
288	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(2), ARHGAP4(1), ARHGAP5(10), ARHGAP6(10), ARHGEF1(1), ARHGEF11(15), ARHGEF5(14), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(6), GSN(3), LIMK1(2), MYL2(4), MYLK(35), OPHN1(3), PIP5K1A(6), PIP5K1B(13), PPP1R12B(7), ROCK1(4), SRC(1), TLN1(11), VCL(7)	14841732	171	91	165	80	117	10	7	22	15	0	0.0807	1.000	1.000
289	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(47), CR2(26), FCGR2B(2), HLA-DRA(10), HLA-DRB1(3), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26)	4955144	148	90	144	58	96	12	5	14	21	0	0.0713	1.000	1.000
290	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(24), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(9), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLCB1(45), PRKCA(10), PTK2(8), RAC1(16), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1)	9086129	169	90	157	68	118	8	6	21	15	1	0.0155	1.000	1.000
291	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(17), ELK1(2), GNAS(17), GRB2(1), HRAS(3), IGF1R(9), ITGB1(4), KLK2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(3), MKNK2(1), MYC(4), NGFR(6), PDGFRA(23), PPP2CA(1), PTPRR(16), RAF1(7), RPS6KA1(6), RPS6KA5(3), SHC1(1), SOS1(7), SRC(1), STAT3(10)	10837865	163	90	154	82	98	16	9	28	12	0	0.470	1.000	1.000
292	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(17), AXIN1(9), CCND1(1), CD14(4), CTNNB1(11), DVL1(1), FZD1(4), GJA1(6), GNAI1(1), GSK3B(2), IRAK1(4), LBP(6), LEF1(3), LY96(4), MYD88(4), NFKB1(7), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(25), TOLLIP(1), WNT1(1)	10013730	133	90	130	63	77	11	9	18	17	1	0.453	1.000	1.000
293	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(15), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), DDC(12), EPX(5), ESCO1(1), ESCO2(2), GOT1(3), GOT2(4), HPD(4), LPO(15), MAOA(2), MAOB(11), MPO(11), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(12), TPO(33)	11305879	188	90	185	118	132	17	9	18	12	0	0.732	1.000	1.000
294	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(6), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(2), ALG8(5), ALG9(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(2), DPAGT1(2), DPM1(1), FUT8(7), GANAB(3), MAN1A1(13), MAN1A2(4), MAN1B1(3), MAN1C1(4), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), RFT1(3), RPN2(2), ST6GAL1(4), STT3B(5)	13966640	144	90	141	77	84	14	11	18	17	0	0.440	1.000	1.000
295	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(2), ANXA3(3), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(11), EDN1(7), EDNRA(8), EDNRB(4), HPGD(1), HSD11B1(10), HSD11B2(2), PLA2G4A(10), PRL(1), PTGDR(9), PTGDS(1), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), PTGIS(10), PTGS1(14), PTGS2(9), S100A6(1), SCGB1A1(1), TBXAS1(9)	6745101	155	90	150	58	106	16	3	15	15	0	0.000290	1.000	1.000
296	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(17), ATF2(4), AXIN1(9), BMP10(13), BMP2(3), BMP4(2), BMP5(21), BMP7(1), BMPR1A(1), BMPR2(4), CHRD(10), CTNNB1(11), DVL1(1), FZD1(4), GATA4(2), GSK3B(2), MAP3K7(1), MEF2C(2), MYL2(4), NKX2-5(1), NOG(1), NPPA(2), NPPB(3), RFC1(3), TGFB1(1), TGFB3(3), TGFBR2(7), TGFBR3(6), WNT1(1)	11918674	142	89	135	68	92	13	6	14	17	0	0.500	1.000	1.000
297	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(2), EGFR(17), IGF1R(9), MYC(4), POLR2A(10), PPP2CA(1), PRKCA(10), RB1(8), TEP1(27), TERF1(2), TERT(5), TNKS(5), TP53(37), XRCC5(2)	9277010	142	89	134	60	81	8	12	16	23	2	0.0730	1.000	1.000
298	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(24), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(4), GNAS(17), HRAS(3), JUN(1), MAP2K1(11), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), RAF1(7), RPS6KA3(2), SYT1(17)	11447355	178	88	167	101	114	14	10	22	18	0	0.769	1.000	1.000
299	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(14), EGFR(17), GRB2(1), HRAS(3), MAP2K1(11), MAPK1(4), MAPK3(1), PTPRB(64), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SPRY1(6), SPRY2(3), SPRY3(11), SPRY4(1), SRC(1)	8236574	164	88	149	69	113	14	6	19	12	0	0.194	1.000	1.000
300	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(5), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CD40(4), CD40LG(1), CRADD(1), CYCS(1), DAXX(8), DFFA(2), DFFB(3), FAS(5), FASLG(12), IKBKE(8), LTA(1), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(6), NR3C1(6), NTRK1(12), PTPN13(11), RIPK1(1), SFRS2IP(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF1(5), TRAF2(1), TRAF3(5), TRAF6(4)	14288881	155	87	154	84	91	14	9	21	20	0	0.764	1.000	1.000
301	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(4), CRK(2), CXCL12(2), CXCR4(3), GNAI1(1), GNAQ(4), HRAS(3), MAP2K1(11), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(39), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTK2(8), PTK2B(8), PXN(3), RAF1(7), RELA(4)	9057765	137	87	125	64	87	9	3	24	13	1	0.327	1.000	1.000
302	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(3), ADCY3(2), ADCY9(9), ARF4(3), ARF5(1), ARL4D(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), ERO1L(4), GNAS(17), PDIA4(3), PLCG1(7), PLCG2(22), PRKCA(10), SEC61A1(2), SEC61A2(7), TRIM23(2)	12242971	163	87	158	101	105	8	9	24	17	0	0.653	1.000	1.000
303	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(15), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), DDC(12), EPX(5), GOT1(3), GOT2(4), HPD(4), LPO(15), MAOA(2), MAOB(11), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(12), TPO(33)	7225532	163	87	160	94	120	14	8	11	10	0	0.119	1.000	1.000
304	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(2), CP(9), CPOX(2), EPRS(9), FECH(3), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(2), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27), UROS(1)	9124512	156	87	148	75	100	16	12	9	18	1	0.184	1.000	1.000
305	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(11), ATR(18), BRCA1(8), BRCA2(17), CHEK1(1), CHEK2(2), FANCA(7), FANCC(3), FANCD2(9), FANCE(2), FANCF(1), FANCG(3), HUS1(1), MRE11A(4), RAD1(2), RAD17(5), RAD50(3), RAD9A(4), TP53(37)	14576145	138	86	131	52	78	4	9	21	26	0	0.333	1.000	1.000
306	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(20), GRB2(1), HRAS(3), INSR(19), IRS1(5), JAK2(7), MAP2K1(11), MAPK1(4), MAPK3(1), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTPN6(2), RAF1(7), RPS6KA1(6), SHC1(1), SLC2A4(7), SOS1(7), SRF(3), STAT5A(2), STAT5B(4)	10942545	139	86	130	73	79	13	6	27	13	1	0.665	1.000	1.000
307	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(1), CRKL(2), GNAQ(4), GRB2(1), HRAS(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), PAK1(4), PLCG1(7), PRKCA(10), PTK2B(8), RAC1(16), RAF1(7), SHC1(1), SOS1(7), SRC(1), SYT1(17)	9380780	133	86	114	63	84	11	5	21	12	0	0.384	1.000	1.000
308	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(3), AKT2(8), AKT3(4), DAG1(5), GNAQ(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(21), PITX2(4), PLD1(9), PLD2(5), PLD3(1)	14763656	145	86	140	86	66	15	13	32	19	0	0.719	1.000	1.000
309	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(15), CD2(21), CD33(15), CD5(5), CSF2(1), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL3(2), IL4(1), IL5(2), ITGAX(15), TLR2(13), TLR4(25), TLR7(15), TLR9(12)	6118515	156	85	151	83	109	10	8	13	16	0	0.0162	1.000	1.000
310	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2)	8280553	148	85	132	68	102	13	6	21	6	0	0.351	1.000	1.000
311	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(27), ACE2(7), AGT(5), AGTR1(9), AGTR2(10), ANPEP(15), CMA1(5), CPA3(14), CTSA(4), CTSG(2), ENPEP(25), LNPEP(9), MAS1(3), MME(17), NLN(4), REN(8), THOP1(6)	6944195	170	85	163	89	118	12	12	11	17	0	0.125	1.000	1.000
312	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(4), CAPN2(7), CAPNS1(1), CXCR3(3), EGF(14), EGFR(17), HRAS(3), ITGA1(16), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(4), MYLK(35), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTK2(8), PXN(3), TLN1(11)	10701633	156	85	151	91	103	11	8	20	14	0	0.542	1.000	1.000
313	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), DAG1(5), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(10), PDE6C(20), PDE6D(2), PDE6G(2), SLC6A13(21), TF(10)	11749943	148	85	142	86	103	8	6	13	18	0	0.249	1.000	1.000
314	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(10), DIAPH1(6), FYN(5), GSN(3), HRAS(3), ITGA1(16), ITGB1(4), MAP2K1(11), MAPK1(4), MAPK3(1), MYL2(4), MYLK(35), PIK3CA(6), PIK3R1(3), PTK2(8), PXN(3), RAF1(7), ROCK1(4), SHC1(1), SRC(1), TLN1(11)	12309796	146	84	135	63	91	12	5	23	14	1	0.176	1.000	1.000
315	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(15), CALCR(14), CALCRL(11), CD97(5), CRHR1(6), CRHR2(2), ELTD1(22), EMR1(23), EMR2(4), GHRHR(3), GIPR(1), GLP1R(11), GLP2R(13), GPR64(5), LPHN1(6), LPHN2(30), LPHN3(17), SCTR(6), VIPR1(2), VIPR2(5)	8680779	201	84	186	123	147	11	11	14	18	0	0.206	1.000	1.000
316	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2)	4367728	128	84	110	49	88	13	9	13	5	0	0.00776	1.000	1.000
317	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(6), EXTL1(2), EXTL3(9), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(4), HS6ST1(3), HS6ST2(2), HS6ST3(9), NDST1(4), NDST2(2), NDST3(22), NDST4(41)	6701009	136	83	133	71	86	10	5	19	16	0	0.264	1.000	1.000
318	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CYP2C19(31), CYP2C9(30), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(1), EHHADH(5), ESCO1(1), ESCO2(2), HADHA(8), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2), YOD1(1)	10242521	156	83	145	103	97	17	9	20	13	0	0.957	1.000	1.000
319	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(4), ARSB(1), FUCA1(2), GALNS(4), GBA(3), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), HGSNAT(4), HPSE(9), HPSE2(4), HYAL1(2), IDS(9), IDUA(4), LCT(29), MAN2B1(5), MAN2B2(8), MAN2C1(3), MANBA(6), NAGLU(4), NEU1(6), NEU2(10), NEU3(3), NEU4(8), SPAM1(18)	11251155	165	83	164	84	113	14	5	19	14	0	0.240	1.000	1.000
320	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(4), CDC42(2), DAXX(8), DDIT3(2), ELK1(2), GRB2(1), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K5(15), MAP3K7(1), MAP3K9(20), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(3), MYC(4), PLA2G4A(10), RAC1(16), RIPK1(1), RPS6KA5(3), SHC1(1), STAT1(3), TGFB1(1), TGFB3(3), TRAF2(1)	11978929	140	83	129	55	87	11	3	22	17	0	0.186	1.000	1.000
321	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(8), AKT3(4), CISH(2), GRB2(1), IARS(8), IL13RA1(3), IL2RG(2), IL4(1), IL4R(12), INPP5D(24), JAK1(5), JAK2(7), JAK3(4), NR0B2(3), PI3(5), PIK3CA(6), PPP1R13B(6), RPS6KB1(2), SERPINA4(12), SHC1(1), SOS1(7), SOS2(11), SRC(1), STAT6(7), TYK2(7)	12142110	152	83	149	71	92	11	8	24	17	0	0.404	1.000	1.000
322	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(8), CARM1(6), CCND1(1), CREBBP(17), EP300(13), ERCC3(1), ESR1(5), GRIP1(8), GTF2A1(2), GTF2E1(2), GTF2F1(4), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(8), HDAC5(6), HDAC6(2), MEF2C(2), NCOR2(22), NR0B1(1), NRIP1(6), PELP1(9), POLR2A(10), TBP(4)	14978305	144	82	144	70	95	6	11	23	9	0	0.498	1.000	1.000
323	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(4), CRY1(5), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(10), GFRA1(7), GSTM3(3), GSTP1(2), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(5), NCOA4(4), NR1D2(9), PER1(7), PER2(8), PIGF(2), PPP1R3C(2), PPP2CB(2), PSMA4(1), PURA(3), SF3A3(4), TOB1(2), TUBB3(3), UCP3(4), UGP2(1), VAPA(1), ZFR(8)	12043292	139	82	137	58	63	13	12	31	20	0	0.541	1.000	1.000
324	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(12), EIF4G2(5), EIF4G3(15), GHR(20), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(3), PABPC1(4), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PRKCA(10), PTEN(18), RPS6KB1(2)	9339359	129	82	122	40	63	15	10	15	25	1	0.0378	1.000	1.000
325	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(15), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), AOC2(7), AOC3(8), ASPA(3), CNDP1(7), DDC(12), HAL(11), HARS(7), HDC(16), HNMT(1), MAOA(2), MAOB(11), PRPS1(2), PRPS2(3)	8018441	145	82	142	89	94	13	9	15	14	0	0.525	1.000	1.000
326	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(15), ACY1(1), ADC(5), AGMAT(2), ALDH18A1(7), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(5), ASS1(6), CPS1(17), GATM(4), MAOA(2), MAOB(11), NAGS(1), ODC1(3), OTC(2), SAT2(1), SMS(5)	9621249	132	82	130	81	77	13	11	15	16	0	0.633	1.000	1.000
327	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(7), ADC(5), ALDH4A1(5), ALDH5A1(8), CAD(12), CPS1(17), EPRS(9), GAD1(12), GAD2(7), GCLC(4), GCLM(2), GFPT1(4), GFPT2(6), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(2), GMPS(1), GOT1(3), GOT2(4), GPT(3), GPT2(1), GSS(7), NADSYN1(4), NAGK(1), QARS(5)	13046566	136	82	132	72	73	15	11	24	13	0	0.483	1.000	1.000
328	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1RAP(4), IL1RN(5), IL6(2), IRAK1(4), IRAK2(9), IRAK3(5), JUN(1), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(4), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	9719883	110	82	107	57	66	10	4	18	12	0	0.475	1.000	1.000
329	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(5), HLA-A(3), IL18(2), ITGB1(4), KLRC1(3), KLRC2(1), KLRC3(11), KLRC4(4), KLRD1(3), LAT(1), MAP2K1(11), MAPK3(1), PAK1(4), PIK3CA(6), PIK3R1(3), PTK2B(8), PTPN6(2), RAC1(16), SYK(12), VAV1(13)	6118135	113	82	97	56	80	4	2	15	11	1	0.460	1.000	1.000
330	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(4), CDC42(2), CREB3(1), CREB5(7), DUSP10(5), EEF2K(5), ELK1(2), HSPB1(2), IL1R1(10), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K10(7), MAP3K4(15), MAP3K5(15), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(3), MKNK2(1), MYEF2(4), NFKB1(7), NR2C2(2), SRF(3), TRAF6(4)	10976258	137	82	133	71	86	11	3	23	14	0	0.509	1.000	1.000
331	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(9), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(5), EIF1AX(2), EIF2AK1(3), EIF2AK2(3), EIF2AK3(17), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(12), EIF4G3(15), EIF5(2), EIF5B(2), ETF1(2), GSPT2(6), KIAA0664(4), PABPC1(4), PABPC3(6), PAIP1(7), SLC35A4(4)	14403080	131	82	122	67	62	12	8	21	28	0	0.856	1.000	1.000
332	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(7), ACACA(18), ACACB(15), ACADM(5), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH7A1(8), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), HIBCH(1), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(1), MUT(5), PCCA(3), PCCB(2), SUCLG1(1), SUCLG2(2)	13153760	135	81	129	70	74	13	14	25	9	0	0.526	1.000	1.000
333	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(17), AXIN1(9), CREBBP(17), CTNNB1(11), DVL1(1), EP300(13), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(38), WNT1(1)	10973086	123	81	119	68	65	10	10	20	18	0	0.901	1.000	1.000
334	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(9), CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), HDAC5(6), IGF1(9), IGF1R(9), INSR(19), MAP2K6(2), MAPK14(5), MAPK7(3), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1), NFATC1(13), NFATC2(6), PIK3CA(6), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(17)	11492139	144	80	138	77	92	14	5	22	10	1	0.447	1.000	1.000
335	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(4), GTF2F2(1), GTF2H1(3), GTF2H4(1), GTF2I(2), GTF2IRD1(8), TAF1(10), TAF13(2), TAF1L(46), TAF2(5), TAF4(8), TAF4B(2), TAF5L(3), TAF6(3), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3)	11969233	140	80	136	58	92	11	6	22	9	0	0.283	1.000	1.000
336	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(3), UCHL1(3), UCHL3(2), UGDH(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27)	5851326	127	80	116	69	86	12	10	5	13	1	0.297	1.000	1.000
337	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(5), BCL2(2), BIRC2(3), BIRC3(6), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(11), LMNA(8), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), SPTAN1(7), TNFRSF10A(5), TNFRSF10B(1), TNFRSF25(4), TNFSF10(7), TNFSF12(1), TRAF2(1)	11028556	107	79	107	66	57	13	10	19	8	0	0.918	1.000	1.000
338	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(5), BTRC(4), CDC16(1), CDC20(1), CDC23(3), CDC27(9), CUL1(5), CUL2(4), CUL3(4), FBXW11(4), FBXW7(10), FZR1(6), ITCH(6), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(2), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E2(2), UBE2E3(1), VHL(4), WWP1(3), WWP2(6)	13161270	129	79	123	57	77	4	10	22	15	1	0.638	1.000	1.000
339	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(7), ADSL(3), ADSS(2), AGXT(7), AGXT2(16), ASL(5), ASNS(8), ASPA(3), CAD(12), CRAT(5), DARS(4), DDO(7), GAD1(12), GAD2(7), GOT1(3), GOT2(4), GPT(3), GPT2(1), NARS(2), PC(12)	8637212	127	78	121	62	85	12	8	14	8	0	0.0930	1.000	1.000
340	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(7), F2(9), F2R(5), F5(24), F7(7), FGA(32), FGB(6), FGG(7), PROC(4), PROS1(12), SERPINC1(6), TFPI(7)	5420987	126	78	120	49	82	16	8	13	7	0	0.0893	1.000	1.000
341	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(21), F2(9), F2R(5), FGA(32), FGB(6), FGG(7), PLAT(3), PLAU(1), PLG(25), SERPINB2(16), SERPINE1(5)	4407342	131	78	126	44	99	7	7	12	6	0	0.0123	1.000	1.000
342	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(7), ACACA(18), ACADL(4), ACADM(5), ACADSB(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), LDHA(4), LDHB(2), LDHC(5), MCEE(2), MLYCD(1), MUT(5), PCCA(3), PCCB(2), SDS(2), SUCLG1(1), SUCLG2(2)	10979176	117	78	113	59	69	10	10	22	6	0	0.584	1.000	1.000
343	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(24), AKT1(3), BAX(3), BCL2(2), CSF2RB(14), IGF1(9), IGF1R(9), IL3(2), IL3RA(5), KIT(8), KITLG(6), PIK3CA(6), PIK3R1(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	7219664	113	77	112	71	68	13	7	11	13	1	0.718	1.000	1.000
344	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(14), EGFR(17), ELK1(2), FOS(2), GRB2(1), HRAS(3), JAK1(5), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(3), STAT3(10), STAT5A(2)	12345828	128	77	122	70	68	14	7	26	12	1	0.928	1.000	1.000
345	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(5), ACO2(4), CLYBL(5), CS(2), DLD(2), FH(3), IDH1(11), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), OGDH(10), OGDHL(31), PC(12), PCK1(16), PCK2(4), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(1), SUCLG2(2)	9907559	134	77	122	59	93	3	7	18	13	0	0.0487	1.000	1.000
346	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BCL2(2), CBL(8), CFLAR(4), CRKL(2), E2F1(4), FOS(2), GRB2(1), HRAS(3), IL2RA(3), IL2RB(7), IL2RG(2), IRS1(5), JAK1(5), JAK3(4), MAPK1(4), MAPK3(1), MYC(4), NMI(1), PIK3CA(6), PIK3R1(3), PPIA(1), PTPN6(2), RAF1(7), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(7), STAT5A(2), STAT5B(4), SYK(12)	11864684	114	77	113	61	60	12	11	16	14	1	0.746	1.000	1.000
347	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(10), ABCC2(7), ABCG2(5), BCHE(5), CES1(16), CES2(3), CYP3A4(16), CYP3A5(10), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10)	7564108	140	77	132	66	92	12	11	9	16	0	0.0266	1.000	1.000
348	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(16), ATP4B(1), ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), ATP7A(9), ATP7B(13), COX10(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(3), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFV1(2), PPA2(2), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2)	12673105	135	77	134	79	80	6	17	20	12	0	0.749	1.000	1.000
349	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(24), ARHGEF1(1), F2(9), F2R(5), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(4), MAP3K7(1), PIK3CA(6), PIK3R1(3), PLCB1(45), PPP1R12B(7), PRKCA(10), PTK2B(8), ROCK1(4)	8525737	135	77	131	68	91	10	5	17	11	1	0.345	1.000	1.000
350	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(17), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(7), DAG1(5), EPHB2(21), FOS(2), GNAQ(4), ITPKB(5), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5)	9373915	111	77	109	58	66	7	5	14	19	0	0.631	1.000	1.000
351	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(24), CD3D(4), CD3G(1), CD4(6), CREBBP(17), CSK(1), GNAS(17), HLA-DRA(10), HLA-DRB1(3), LCK(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(26), ZAP70(4)	7464576	142	76	138	82	92	13	7	17	13	0	0.678	1.000	1.000
352	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(10), ATM(11), BRCA1(8), CDKN1A(4), CHEK1(1), CHEK2(2), JUN(1), MAPK8(1), MDM2(3), MRE11A(4), NFKB1(7), NFKBIA(2), RAD50(3), RBBP8(3), RELA(4), TP53(37), TP73(5)	9798075	106	76	100	33	43	12	7	21	23	0	0.137	1.000	1.000
353	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(5), ABAT(7), ACADS(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH5A1(8), ALDH9A1(2), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HMGCL(3), L2HGDH(3), OXCT1(4), PDHA1(2), PDHA2(15), PDHB(1), SDHB(1), SDS(2)	8563701	121	76	116	56	75	14	4	17	11	0	0.133	1.000	1.000
354	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(12), FOS(2), HRAS(3), JUN(1), MAP2K1(11), MAPK1(4), MAPK3(1), MYC(4), NFKB1(7), NFKBIA(2), PLCB1(45), PRKCA(10), RAF1(7), RELA(4), TNF(1)	5141821	114	76	104	40	78	7	5	14	10	0	0.00504	1.000	1.000
355	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(24), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), GNAS(17), GRB2(1), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(6), PIK3R1(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), RAC1(16), RPS6KA1(6), RPS6KA5(3), SOS1(7)	9529829	144	76	133	82	97	10	6	15	15	1	0.741	1.000	1.000
356	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(24), CD3D(4), CD3G(1), CD4(6), CREBBP(17), CSK(1), GNAS(17), HLA-DRA(10), HLA-DRB1(3), LCK(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(26), ZAP70(4)	7464576	142	76	138	82	92	13	7	17	13	0	0.678	1.000	1.000
357	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JAK1(5), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(3), STAT3(10), STAT5A(2)	11495188	121	76	115	54	61	14	6	25	14	1	0.530	1.000	1.000
358	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MAPKAPK5(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(6), PIK3CD(7), PIK3R1(3), SYT1(17), TRAF2(1), TRAF3(5), TRAF5(6), TRAF6(4)	11016197	127	76	122	66	79	9	6	23	9	1	0.333	1.000	1.000
359	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(13), ABP1(15), AOC2(7), AOC3(8), CES1(16), CES7(12), DDHD1(6), ESCO1(1), ESCO2(2), LIPA(4), MYST3(12), MYST4(9), NAT6(1), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2)	8377781	124	75	121	68	88	7	7	11	11	0	0.726	1.000	1.000
360	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(7), ECHS1(1), EHHADH(5), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(5), PLOD3(4), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1)	12140939	113	75	109	65	68	13	4	20	8	0	0.610	1.000	1.000
361	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(7), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR7(3), CD28(1), CD4(6), CSF2(1), CXCR3(3), CXCR4(3), IFNG(1), IFNGR1(4), IFNGR2(4), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18R1(16), IL2(2), IL4(1), IL4R(12), IL5(2), TGFB1(1), TGFB3(3)	6586153	124	75	118	65	87	9	1	15	12	0	0.0817	1.000	1.000
362	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), DIAPH2(6), MCM10(5), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), PRIM1(3), RFC1(3), RFC2(2), RPA1(3), RPA2(2), RPA3(1), RPA4(2), UBB(1), UBC(4)	16711072	118	74	118	71	68	8	5	22	15	0	0.905	1.000	1.000
363	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CFLAR(4), DAXX(8), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(16), PTPN13(11), RB1(8), RIPK2(2), SPTAN1(7)	13548412	121	74	121	57	52	11	10	32	14	2	0.771	1.000	1.000
364	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(7), ALDH4A1(5), ALDH5A1(8), CAD(12), CPS1(17), EPRS(9), GAD1(12), GAD2(7), GCLC(4), GCLM(2), GFPT1(4), GLS(1), GLS2(2), GLUD1(1), GLUL(2), GMPS(1), GOT1(3), GOT2(4), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(5)	10971763	121	74	117	59	67	11	10	22	11	0	0.361	1.000	1.000
365	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), GOT1(3), GOT2(4), GPT(3), GPT2(1), MDH1(1), MDH2(3), ME1(17), ME3(8), PGK1(4), PGK2(22), PKLR(8), PKM2(3), TKT(5), TKTL2(20)	6689457	119	74	109	69	82	13	5	13	6	0	0.238	1.000	1.000
366	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(10), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(4), MYL2(4), MYLK(35), PLCB1(45), PPP1R12B(7), PRKCA(10), ROCK1(4)	6864952	124	74	115	51	94	4	5	13	8	0	0.0779	1.000	1.000
367	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(5), ATM(11), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(10), PTK2(8), PXN(3), STAT1(3), TLN1(11), TP53(37)	9013735	106	73	99	31	49	10	8	16	23	0	0.0123	1.000	1.000
368	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(8), ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(1), GMPPB(2), HK1(3), HK2(11), HK3(12), HSD3B7(3), LHPP(1), MPI(1), MTMR1(4), MTMR2(1), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB3(1), PFKFB4(3), PFKL(4), PFKM(1), PGM2(5), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2)	12174626	114	73	110	82	76	13	8	11	6	0	0.732	1.000	1.000
369	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLG(6), POLG2(4), POLH(2), POLI(1), POLK(6), POLL(6), POLM(2), POLQ(22), PRIM1(3), PRIM2(12), REV1(2), REV3L(11)	13368725	116	73	114	49	64	4	7	27	14	0	0.487	1.000	1.000
370	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(5), CASP1(2), CASP3(2), CASP7(4), CASP8(7), GAPDH(1), INSR(19), ITCH(6), MAGI1(23), MAGI2(19), RERE(19), WWP1(3), WWP2(6)	7955726	121	73	119	55	79	9	3	19	10	1	0.456	1.000	1.000
371	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(3), EIF4EBP1(1), EIF4G1(12), EIF4G2(5), EIF4G3(15), FKBP1A(2), MKNK1(3), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), PTEN(18), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(11)	9134700	103	73	99	31	42	11	11	15	22	2	0.0711	1.000	1.000
372	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(17), EP300(13), IKBKB(3), IL1B(6), IL8(1), MAP2K3(7), MAP2K6(2), MAP3K14(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(4), NFKB1(7), NFKBIA(2), NR3C1(6), RELA(4), TGFBR2(7), TLR2(13), TNF(1)	9806381	105	72	104	58	60	14	5	20	6	0	0.856	1.000	1.000
373	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(1), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(1), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(13), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(3), TAF7(2), TAF9(2), TBP(4)	11608240	99	72	98	36	57	8	8	18	8	0	0.0871	1.000	1.000
374	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(6), PDE1A(32), PDE1B(10), PLCB1(45), PLCB2(6), PRL(1), TRH(3), VIP(3)	3626431	111	72	101	48	89	2	2	11	7	0	0.0258	1.000	1.000
375	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(13), COMT(3), DBH(13), DDC(12), GAD1(12), GAD2(7), HDC(16), MAOA(2), PAH(9), PNMT(2), SLC18A3(2), TH(7), TPH1(5)	4656696	107	71	102	60	85	8	3	3	8	0	0.115	1.000	1.000
376	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(5), AGTR2(10), EDN1(7), EDNRA(8), EDNRB(4), EGF(14), EGFR(17), FOS(2), HRAS(3), JUN(1), MYC(4), NFKB1(7), PLCG1(7), PRKCA(10), RELA(4)	6777078	112	71	109	57	75	10	5	16	6	0	0.342	1.000	1.000
377	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(10), EGF(14), EGFR(17), GRB2(1), MET(19), PDGFRA(23), PRKCA(10), SH3GLB1(2), SH3GLB2(1), SH3KBP1(5), SRC(1)	6434888	111	71	110	67	70	10	6	13	12	0	0.853	1.000	1.000
378	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(7), CSF1R(10), DDX20(7), E2F1(4), E2F4(1), ETS1(3), ETS2(7), ETV3(4), FOS(2), HDAC2(1), HDAC5(6), HRAS(3), JUN(1), NCOR2(22), RBL1(10), RBL2(4), SIN3A(8), SIN3B(6)	8574607	106	71	106	50	66	7	2	20	11	0	0.251	1.000	1.000
379	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(3), ARSE(5), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(7), LCT(29), NEU1(6), NEU2(10), NEU3(3), NEU4(8), PPAP2B(5), PPAP2C(6), SMPD1(3), SMPD2(1), SPTLC1(2), SPTLC2(5), UGCG(1)	7898645	110	71	107	69	73	12	2	16	7	0	0.785	1.000	1.000
380	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(5), ACTN2(16), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(16), ITGB1(4), ITGB3(9), PTK2(8), PXN(3), RAC1(16), SPTAN1(7), SRC(1), TLN1(11)	9286992	110	71	100	48	70	9	5	14	11	1	0.0160	1.000	1.000
381	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(1), ITGA4(29), ITGAL(19), ITGB1(4), ITGB2(10), SELE(28), SELL(7)	3955279	103	70	101	33	74	4	3	8	14	0	0.0140	1.000	1.000
382	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(6), GALNT2(5), GALNT3(3), GALNT4(3), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GCNT1(6), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), WBSCR17(36)	4784390	109	70	102	46	81	7	4	9	8	0	0.0568	1.000	1.000
383	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(4), CSNK1D(1), DRD1(6), DRD2(13), GRM1(14), PLCB1(45), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	5256480	110	69	105	69	83	2	6	10	9	0	0.599	1.000	1.000
384	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(15), G6PD(4), GCLC(4), GCLM(2), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GPX6(15), GSS(7), GSTA1(5), GSTA2(2), GSTA5(3), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), IDH1(11), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(5), TXNDC12(1)	7201664	115	69	105	62	78	7	6	16	8	0	0.131	1.000	1.000
385	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(17), EP300(13), FYN(5), IL2RG(2), IL7(5), IL7R(24), JAK1(5), JAK3(4), LCK(10), NMI(1), PIK3CA(6), PIK3R1(3), PTK2B(8), STAT5A(2), STAT5B(4)	9200062	111	69	109	59	65	12	5	19	9	1	0.744	1.000	1.000
386	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(28), ABCB11(37), ABCB4(13), ABCC1(10), ABCC3(19), GSTP1(2)	4690518	109	69	104	58	68	13	5	9	14	0	0.0532	1.000	1.000
387	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(28), AKT1(3), ATM(11), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(3), NFKBIB(1), NQO1(1), TP53(37)	6868573	104	69	94	35	50	8	6	16	24	0	0.111	1.000	1.000
388	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(1), GSK3B(2), IL4R(12), IRS1(5), IRS2(2), JAK1(5), JAK3(4), MAP4K1(8), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PPP1R13B(6), RAF1(7), SHC1(1), SOS1(7), SOS2(11), STAT6(7)	12046344	118	69	118	48	63	16	5	20	13	1	0.150	1.000	1.000
389	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), GBA3(14), LPO(15), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(33), TYR(7)	3190336	93	69	89	45	71	7	1	6	8	0	0.0902	1.000	1.000
390	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(4), DAB1(33), FYN(5), LRP8(3), RELN(58), VLDLR(4)	4612440	107	68	103	57	74	6	2	12	13	0	0.811	1.000	1.000
391	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(3), EGR3(2), GNAQ(4), MAP3K1(2), MYC(4), NFATC1(13), NFATC2(6), NFKB1(7), NFKBIA(2), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(4), SYT1(17), VIP(3), VIPR2(5)	9196673	113	68	109	74	75	9	7	14	8	0	0.931	1.000	1.000
392	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(17), AXIN1(9), BTRC(4), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(11), DVL1(1), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(4), NLK(5), PPARD(2), PPP2CA(1), TLE1(4), WIF1(7), WNT1(1)	9629208	96	68	95	50	50	6	8	14	18	0	0.846	1.000	1.000
393	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(27), AGT(5), AGTR1(9), AGTR2(10), BDKRB2(9), KNG1(8), NOS3(14), REN(8)	3263245	90	67	86	50	58	5	6	12	9	0	0.162	1.000	1.000
394	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(4), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), HGSNAT(4), HPSE(9), HPSE2(4), HYAL1(2), IDS(9), IDUA(4), LCT(29), NAGLU(4), SPAM1(18)	6705179	107	67	106	60	77	6	2	12	10	0	0.543	1.000	1.000
395	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(7), AKR1D1(17), CYP11A1(11), CYP11B1(11), CYP11B2(11), CYP17A1(6), CYP21A2(14), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7)	3233793	106	66	97	49	73	10	5	11	7	0	0.00540	1.000	1.000
396	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(14), EGFR(17), MAP2K1(11), MAP3K1(2), MAPK14(5), NCOR2(22), RARA(3), RXRA(4), THRA(2), THRB(12)	5658383	92	66	87	46	64	6	3	14	5	0	0.456	1.000	1.000
397	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(15), G6PD(4), GCLC(4), GCLM(2), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GSS(7), GSTA1(5), GSTA2(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), IDH1(11), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(7)	5953366	96	66	87	40	65	5	6	13	7	0	0.0124	1.000	1.000
398	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(7), AKR1D1(17), CYP11A1(11), CYP11B1(11), CYP11B2(11), CYP17A1(6), CYP21A2(14), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7)	3233793	106	66	97	49	73	10	5	11	7	0	0.00540	1.000	1.000
399	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(7), CHIT1(9), CMAS(1), CTBS(5), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(3), HEXA(4), HEXB(3), HK1(3), HK2(11), HK3(12), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(3), UAP1(2)	9455743	88	66	87	45	54	8	4	13	9	0	0.415	1.000	1.000
400	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(15), PGAP1(5), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(7), PIGH(1), PIGK(5), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(7), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGW(2), PIGX(2), PIGZ(3)	7902652	92	66	91	36	50	7	8	20	7	0	0.0661	1.000	1.000
401	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(7), PAFAH1B1(4), PAFAH1B2(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLD1(9), PLD2(5), PPAP2B(5), PPAP2C(6)	7702810	108	66	105	60	63	10	4	17	14	0	0.630	1.000	1.000
402	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(24), CAP1(1), CDC25C(2), GNAI1(1), GNAS(17), HRAS(3), MAPK1(4), MAPK3(1), MYT1(19), PIN1(1), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RPS6KA1(6), SRC(1)	6756155	101	66	98	75	68	8	4	8	13	0	0.929	1.000	1.000
403	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), CASP9(2), CDC42(2), CHUK(2), ELK1(2), H2AFX(2), HRAS(3), MAP2K1(11), MAPK3(1), NFKB1(7), PIK3CA(6), PIK3R1(3), RAC1(16), RAF1(7), RALA(1), RALBP1(2), RALGDS(8), RELA(4), RHOA(1)	6227782	83	66	70	36	49	10	2	17	4	1	0.298	1.000	1.000
404	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(6), CBS(6), CTH(1), GGT1(4), HEMK1(4), LCMT1(3), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), METTL2B(7), METTL6(2), PAPSS1(2), PAPSS2(5), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1)	8283870	90	65	90	41	51	11	5	15	8	0	0.162	1.000	1.000
405	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(1), CCNE1(3), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(4), HRAS(3), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(6), PIK3R1(3), RAC1(16), RAF1(7), RB1(8), RELA(4), TFDP1(2)	6641926	90	65	81	30	44	7	6	18	12	3	0.0421	1.000	1.000
406	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAPK3(1), MPL(7), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), STAT1(3), STAT3(10), STAT5A(2), STAT5B(4), THPO(6)	9854658	104	65	98	46	54	11	6	22	10	1	0.578	1.000	1.000
407	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(16), EPHB1(22), FYN(5), ITGA1(16), ITGB1(4), L1CAM(8), LYN(5), RAP1B(1), SELP(28)	5208273	107	64	97	54	77	4	2	16	8	0	0.387	1.000	1.000
408	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GPHN(7), NSF(1), SRC(1), UBQLN1(5)	3868805	95	64	85	49	70	3	5	10	6	1	0.340	1.000	1.000
409	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(2), BCR(10), CRKL(2), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(4), PIK3CA(6), PIK3R1(3), RAF1(7), SOS1(7), STAT1(3), STAT5A(2), STAT5B(4)	9219474	86	64	81	41	43	8	5	18	11	1	0.699	1.000	1.000
410	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(9), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(5), PFKL(4), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(11), PRPS2(3), RBKS(4), TALDO1(2), TKT(5), TKTL2(20)	7994574	96	64	90	69	61	10	5	9	11	0	0.730	1.000	1.000
411	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4EBP1(1), GSK3B(2), IGF1(9), IGF1R(9), INPPL1(14), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), PTEN(18), RPS6(1), RPS6KB1(2)	6478604	77	64	73	28	33	8	8	11	16	1	0.262	1.000	1.000
412	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(24), ADRB2(2), GNAS(17), PLCE1(41), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	4810738	103	64	99	62	67	9	7	10	10	0	0.721	1.000	1.000
413	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(3), CASP2(1), CASP3(2), CASP8(7), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MADD(14), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(16), RB1(8), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(2), TRAF2(1)	12862505	107	64	106	48	48	9	9	25	14	2	0.440	1.000	1.000
414	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(24), ADRB2(2), CFTR(38), GNAS(17), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SLC9A3R1(3)	4266158	103	63	98	70	68	8	6	10	11	0	0.875	1.000	1.000
415	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(17), NFKB1(7), NOS3(14), NPPA(2), NR3C1(6), PIK3CA(6), PIK3R1(3), RELA(4), SYT1(17)	5858698	87	63	82	46	62	6	2	13	3	1	0.682	1.000	1.000
416	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), GBA(3), GBA3(14), LPO(15), MPO(11), PRDX6(4), TPO(33)	2769796	85	63	81	43	66	6	1	6	6	0	0.0841	1.000	1.000
417	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IL2(2), IL2RA(3), IL2RB(7), IL2RG(2), JAK1(5), JAK3(4), JUN(1), LCK(10), MAP2K1(11), MAPK3(1), MAPK8(1), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4), SYK(12)	7585475	89	63	83	42	52	8	5	16	8	0	0.369	1.000	1.000
418	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), ESRRA(2), HDAC5(6), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), PPARA(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(7), SYT1(17)	6614951	95	63	89	53	68	6	3	10	8	0	0.420	1.000	1.000
419	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(2), GLI2(32), GLI3(15), GSK3B(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SHH(4), SMO(10), SUFU(2)	5468723	88	63	87	53	55	10	7	8	8	0	0.664	1.000	1.000
420	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(18), BST1(1), CD38(2), ENPP1(10), ENPP3(14), NADK(3), NADSYN1(4), NMNAT2(2), NMNAT3(7), NNMT(7), NNT(4), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), NUDT12(1), QPRT(5)	7118470	109	62	106	61	70	8	6	12	13	0	0.665	1.000	1.000
421	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3D(4), CD3G(1), CXCR3(3), ETV5(6), IFNG(1), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18(2), IL18R1(16), JAK2(7), JUN(1), MAP2K6(2), MAPK14(5), MAPK8(1), STAT4(20), TYK2(7)	6122777	100	62	97	50	65	6	3	15	11	0	0.525	1.000	1.000
422	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(3), IL1A(4), IL1R1(10), IRAK1(4), MAP3K1(2), MAP3K14(3), MAP3K7(1), MYD88(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TLR4(25), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(3), TRAF6(4)	7903842	83	62	81	48	56	5	5	11	6	0	0.725	1.000	1.000
423	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(6), PIK3R1(3), PLCB1(45), PLCG1(7), PRKCA(10), VAV1(13)	4245758	87	62	83	41	68	3	2	8	5	1	0.271	1.000	1.000
424	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(27), CD44(5), CSF1(7), FCGR3A(6), IL1B(6), IL6R(4), SELL(7), SPN(3), TGFB1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF8(16), TNFSF8(3)	4266233	91	62	86	39	66	2	6	5	12	0	0.0514	1.000	1.000
425	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(7), CNR2(4), DNMT1(16), MTNR1A(7), MTNR1B(5), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), TBXA2R(4)	3679888	85	62	81	60	56	10	5	7	7	0	0.307	1.000	1.000
426	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(9), DARS(4), EPRS(9), FARS2(4), GARS(5), HARS(7), IARS(8), KARS(4), LARS(9), LARS2(2), MARS(5), MARS2(3), NARS(2), QARS(5), RARS(7), SARS(10), TARS(1), WARS(4), WARS2(4), YARS(1)	10653299	107	61	102	41	65	10	6	17	9	0	0.0966	1.000	1.000
427	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(11), BCAT2(1), IARS(8), IARS2(12), ILVBL(3), LARS(9), LARS2(2), PDHA1(2), PDHA2(15), PDHB(1), VARS(18), VARS2(5)	6240861	87	61	77	39	56	8	3	11	9	0	0.290	1.000	1.000
428	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(4), FUCA1(2), GLB1(7), HEXA(4), HEXB(3), LCT(29), MAN2B1(5), MAN2B2(8), MAN2C1(3), MANBA(6), NEU1(6), NEU2(10), NEU3(3), NEU4(8)	6689304	98	61	98	50	69	10	3	12	4	0	0.288	1.000	1.000
429	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(2), CA1(8), CA12(3), CA13(4), CA2(7), CA3(5), CA4(3), CA5A(1), CA5B(1), CA6(2), CA7(1), CA8(4), CA9(6), CPS1(17), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(2), HAL(11)	6953356	94	61	94	46	64	5	4	12	9	0	0.347	1.000	1.000
430	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IGF1(9), IGF1R(9), IRS1(5), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PTPN11(9), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3)	8169999	86	61	78	38	39	16	2	20	8	1	0.614	1.000	1.000
431	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), INSR(19), IRS1(5), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PTPN11(9), RAF1(7), RASA1(4), SHC1(1), SLC2A4(7), SOS1(7), SRF(3)	8451789	94	61	87	42	40	14	3	26	10	1	0.669	1.000	1.000
432	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(5), EPX(5), LPO(15), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(2), TPO(33)	3908637	83	61	81	44	64	6	1	8	4	0	0.155	1.000	1.000
433	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(4), HDAC3(5), NCOA1(7), NCOA2(10), NCOA3(12), NCOR2(22), POLR2A(10), RARA(3), RXRA(4), TBP(4)	8198530	89	61	89	35	65	3	5	9	7	0	0.0920	1.000	1.000
434	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(24), GNAS(17), PPP2CA(1), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAG2(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	5033685	93	60	90	57	62	8	7	4	12	0	0.800	1.000	1.000
435	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(15), GMDS(5), GMPPA(1), GMPPB(2), HK1(3), HK2(11), HK3(12), MPI(1), PFKFB1(4), PFKFB3(1), PFKFB4(3), PFKM(1), PMM1(2), PMM2(1), SORD(2)	7856145	85	60	81	64	61	11	5	4	4	0	0.643	1.000	1.000
436	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), NAT1(2), NAT2(8), XDH(44)	2655301	91	60	86	49	70	4	8	4	5	0	0.0308	1.000	1.000
437	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(4), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), OGDH(10), PC(12), PDHA1(2), PDHA2(15), PDHB(1), PDHX(2), PDK1(2), PDK2(2), PDK3(4), PDK4(6), PDP2(5), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(1), SUCLG2(2)	9400274	94	60	90	39	61	5	6	10	12	0	0.110	1.000	1.000
438	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(12), PIR(1), RAC1(16), WASF1(3), WASF2(3), WASF3(11), WASL(5)	5058288	69	59	60	25	45	5	2	10	7	0	0.231	1.000	1.000
439	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(1), CALM2(1), CDKN1A(4), GNAQ(4), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SP1(3), SYT1(17)	6848766	95	59	90	40	64	8	6	9	8	0	0.181	1.000	1.000
440	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(6), PIK3R1(3), RB1(8), RELA(4), SP1(3)	6376852	69	59	63	32	33	7	3	13	10	3	0.638	1.000	1.000
441	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(2), ATG7(8), BECN1(3), GABARAPL1(1), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNG(1), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(19), ULK1(7), ULK2(6), ULK3(1)	6883722	91	59	88	49	59	7	6	13	6	0	0.542	1.000	1.000
442	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IL6(2), IL6R(4), IL6ST(10), JAK1(5), JAK2(7), JAK3(4), JUN(1), MAP2K1(11), MAPK3(1), PTPN11(9), RAF1(7), SHC1(1), SOS1(7), SRF(3), STAT3(10)	7845842	91	59	84	43	38	12	3	26	12	0	0.773	1.000	1.000
443	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(8), AKT3(4), GRB2(1), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(6), PIK3CD(7), PTEN(18), PTK2B(8), RBL2(4), SHC1(1), SOS1(7)	6772703	74	59	72	29	31	6	3	17	17	0	0.481	1.000	1.000
444	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(17), CDH1(4), CREBBP(17), EP300(13), MAP2K1(11), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB3(3), TGFBR2(7)	8496455	77	59	72	41	41	8	3	14	11	0	0.938	1.000	1.000
445	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(16), ACTN3(7), BCAR1(4), CSK(1), CTNNA1(2), CTNNA2(19), CTNNB1(11), PTK2(8), PXN(3), SRC(1), VCL(7)	6221168	84	58	81	41	50	7	4	12	10	1	0.155	1.000	1.000
446	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GPX1(2), PRKCE(5)	2546725	83	58	72	42	63	3	3	9	4	1	0.283	1.000	1.000
447	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(9), CALM1(1), CALM2(1), CAPN2(7), CAPNS1(1), EP300(13), HDAC1(1), HDAC2(1), MEF2D(4), NFATC1(13), NFATC2(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SYT1(17)	8100312	95	58	90	41	65	6	7	10	7	0	0.197	1.000	1.000
448	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(8), CA12(3), CA2(7), CA3(5), CA4(3), CA5A(1), CA5B(1), CA6(2), CA7(1), CA8(4), CA9(6), CPS1(17), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUL(2), HAL(11)	6216027	85	58	85	41	58	4	3	12	8	0	0.332	1.000	1.000
449	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(21), CD3D(4), CD3G(1), CD4(6), CXCR3(3), IFNG(1), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), JAK2(7), STAT4(20), TYK2(7)	4797477	94	58	89	43	58	9	3	13	11	0	0.187	1.000	1.000
450	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(5), LPO(15), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(2), TPO(33)	3861764	80	57	78	44	62	6	1	8	3	0	0.189	1.000	1.000
451	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(18), CPT1A(9), LEP(2), LEPR(19), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKAG1(2), PRKAG2(7)	4825885	80	57	76	45	55	3	4	6	12	0	0.802	1.000	1.000
452	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(2), GRB2(1), HRAS(3), IL3(2), IL3RA(5), JAK2(7), MAP2K1(11), MAPK3(1), PTPN6(2), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4)	5790304	69	56	64	36	39	4	3	13	10	0	0.687	1.000	1.000
453	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(4), FUCA1(2), GLB1(7), HEXA(4), HEXB(3), LCT(29), MAN2C1(3), MANBA(6), NEU1(6), NEU2(10), NEU3(3), NEU4(8)	5430311	85	56	85	44	60	8	2	11	4	0	0.433	1.000	1.000
454	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(12), AP2A1(1), AP2M1(3), BIN1(4), CALM1(1), CALM2(1), DNM1(5), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(18), SYNJ2(13), SYT1(17)	7055500	96	56	92	46	66	9	2	15	4	0	0.364	1.000	1.000
455	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(1), AP2M1(3), BTK(15), EEA1(2), GRASP(1), GSK3B(2), LYN(5), PDPK1(4), PFKL(4), PFKM(1), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(1), RAC1(16), RPS6KB1(2), VAV2(2)	8152715	78	56	68	42	48	5	5	12	8	0	0.331	1.000	1.000
456	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(21), CD28(1), CD3D(4), CD3G(1), CD8A(2), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26), THY1(1)	3501762	86	56	80	41	58	7	2	7	12	0	0.124	1.000	1.000
457	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(21), CD28(1), CD3D(4), CD3G(1), CD4(6), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26), THY1(1)	3670850	90	56	84	43	60	8	2	8	12	0	0.113	1.000	1.000
458	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(4), CS(2), DLD(2), FH(3), IDH1(11), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), PC(12), PCK1(16), SDHA(1), SDHB(1), SUCLG1(1), SUCLG2(2)	6851708	72	55	63	38	51	1	6	8	6	0	0.375	1.000	1.000
459	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(4), CD3G(1), CD80(4), CD86(18), CTLA4(2), GRB2(1), HLA-DRA(10), HLA-DRB1(3), ICOS(3), IL2(2), ITK(19), LCK(10), PIK3CA(6), PIK3R1(3), PTPN11(9)	4218793	96	55	92	34	62	7	1	15	10	1	0.121	1.000	1.000
460	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15(8), ALOX15B(8), ALOX5(7), DPEP1(4), GGT1(4), LTA4H(3), PLA2G2A(2), PLA2G6(8), PTGDS(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9)	4919856	92	55	91	50	64	8	2	10	8	0	0.0818	1.000	1.000
461	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), BHMT(4), CBS(6), CTH(1), DNMT1(16), DNMT3A(5), DNMT3B(8), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), MTAP(2), MTFMT(1), MTR(7), TAT(12)	6930499	81	55	79	34	48	5	8	11	9	0	0.139	1.000	1.000
462	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(5), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(11), PRPS2(3), RBKS(4), TAL1(5), TALDO1(2), TKT(5)	6735422	75	55	72	55	47	6	5	7	10	0	0.788	1.000	1.000
463	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(5), BIRC2(3), BIRC3(6), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), DFFA(2), DFFB(3), GZMB(2), PRF1(7), SCAP(8), SREBF1(5), SREBF2(7)	6010138	65	55	63	33	36	5	7	10	7	0	0.585	1.000	1.000
464	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(10), APOA1(1), APOA4(4), APOC1(2), APOC2(1), APOE(1), CETP(5), CYP7A1(6), DGAT1(1), HMGCR(11), LDLR(10), LIPC(8), LPL(3), LRP1(28), SCARB1(3), SOAT1(3)	9134284	97	55	95	57	52	12	6	16	11	0	0.607	1.000	1.000
465	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), GOT1(3), GOT2(4), GPT(3), GPT2(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PGK1(4), PKLR(8), PKM2(3), TKT(5)	5976452	78	54	75	41	52	8	5	7	6	0	0.194	1.000	1.000
466	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(4), B3GNT1(2), B3GNT2(1), B3GNT3(5), B3GNT4(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(4), FUT6(4), FUT7(2), FUT9(22), ST3GAL6(2), ST8SIA1(1)	5259315	71	54	69	32	44	9	4	7	7	0	0.0798	1.000	1.000
467	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1)	7760432	69	54	68	27	38	6	6	12	7	0	0.164	1.000	1.000
468	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(4), CDKN1B(1), GRB2(1), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PTEN(18), PTK2(8), SHC1(1), SOS1(7)	6318095	67	54	64	24	29	5	3	13	16	1	0.466	1.000	1.000
469	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(3), BIRC3(6), CASP3(2), CASP8(7), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(4), MAP3K7(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1)	8914772	69	54	69	44	35	4	9	16	5	0	0.938	1.000	1.000
470	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(18), HLA-DRA(10), HLA-DRB1(3), IFNG(1), IFNGR1(4), IFNGR2(4), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18(2), IL18R1(16), IL2(2), IL2RA(3), IL4(1), IL4R(12)	4177465	95	54	91	40	69	4	0	9	13	0	0.125	1.000	1.000
471	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(4), CYSLTR2(1), GPR109B(5), GPR161(5), GPR171(8), GPR18(5), GPR34(2), GPR39(10), GPR45(6), GPR65(7), GPR68(3), GPR75(5), GPR81(2)	3226252	63	52	62	32	44	2	4	6	7	0	0.0202	1.000	1.000
472	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(7), HEXA(4), HEXB(3), LCT(29), SLC33A1(5), ST3GAL1(5), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(6), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(6)	5442361	82	52	82	54	56	8	1	13	4	0	0.773	1.000	1.000
473	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(7), MAN1A1(13), MAN1B1(3), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), RPN2(2), ST6GAL1(4)	6599775	73	52	73	44	45	8	3	10	7	0	0.659	1.000	1.000
474	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(18), CD38(2), ENPP1(10), ENPP3(14), NADSYN1(4), NMNAT2(2), NNMT(7), NNT(4), NT5E(3), NT5M(1), QPRT(5)	4815433	70	52	67	35	42	7	4	9	8	0	0.478	1.000	1.000
475	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNB1(1), CHRNG(1), MUSK(28), PIK3CA(6), PIK3R1(3), PTK2(8), PTK2B(8), RAPSN(1), SRC(1), TERT(5)	5362469	65	51	62	50	43	4	1	12	4	1	0.923	1.000	1.000
476	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREBBP(17), EP300(13), NCOA3(12), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RARA(3), RXRA(4)	6838162	74	51	74	41	44	4	4	14	8	0	0.868	1.000	1.000
477	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(5), ARHGDIB(3), BIRC2(3), BIRC3(6), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), DFFA(2), DFFB(3), GZMB(2), LMNA(8), LMNB1(2), LMNB2(4), PRF1(7)	6465148	66	51	66	33	32	9	6	13	6	0	0.696	1.000	1.000
478	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(4), CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(1), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP4K2(4), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(1)	7840716	59	51	59	38	32	9	2	10	6	0	0.859	1.000	1.000
479	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(5), EPOR(1), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PLCG1(7), PTPN6(2), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4)	7028000	66	50	61	35	32	5	5	16	8	0	0.791	1.000	1.000
480	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(3), COPS5(3), EDN1(7), EP300(13), EPO(5), HIF1A(5), JUN(1), LDHA(4), NOS3(14), P4HB(2), VHL(4)	5648847	68	50	67	31	40	3	5	10	10	0	0.547	1.000	1.000
481	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(1), HRAS(3), IGF1R(9), IRS1(5), MAP2K1(11), MAPK1(4), MAPK3(1), PIK3CA(6), PIK3R1(3), RAF1(7), SHC1(1), SOS1(7)	6280733	61	50	56	26	31	8	2	12	7	1	0.447	1.000	1.000
482	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(17), EP300(13), LPL(3), NCOA1(7), NCOA2(10), PPARG(11), RXRA(4)	6146339	65	50	64	27	41	4	3	11	6	0	0.516	1.000	1.000
483	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(24), FHL5(10), FSHB(4), FSHR(13), GNAS(17), XPO1(2)	3121658	70	49	68	44	51	5	4	5	5	0	0.821	1.000	1.000
484	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22)	5520439	56	49	55	22	31	3	2	12	8	0	0.181	1.000	1.000
485	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(4), HTR2C(10), PLCB1(45), TUB(8)	2360005	70	49	66	30	56	1	1	7	5	0	0.0721	1.000	1.000
486	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(7), ARG1(1), ARG2(1), ASL(5), CKM(2), CKMT2(4), CPS1(17), GAMT(3), GATM(4), GLUD1(1), NAGS(1), OAT(2), ODC1(3), OTC(2), PYCR1(1), SMS(5)	5700389	60	49	60	29	34	6	2	9	9	0	0.328	1.000	1.000
487	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(2), CASP8(7), CYCS(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFKB1(7), NSMAF(4), RAF1(7), RELA(4), RIPK1(1), SMPD1(3), TNFRSF1A(2), TRAF2(1)	6724325	65	48	60	25	36	5	3	13	8	0	0.267	1.000	1.000
488	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(11), CYP11A1(11), CYP11B2(11), CYP17A1(6), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7)	2277073	68	48	64	41	50	6	1	5	6	0	0.0671	1.000	1.000
489	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(2), B3GAT3(4), CHPF(3), CHST11(5), CHST12(3), CHST13(2), CHST14(2), CHST3(1), CHSY1(9), DSE(17), XYLT1(8), XYLT2(3)	4375846	65	48	65	37	42	9	3	7	4	0	0.241	1.000	1.000
490	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(7), CSF2(1), CSF3(3), HLA-DRA(10), HLA-DRB1(3), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL15(3), IL1A(4), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL7(5), IL8(1), LTA(1), PDGFA(1), TGFB1(1), TGFB3(3), TNF(1)	4337184	73	48	73	36	47	3	3	9	11	0	0.0600	1.000	1.000
491	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(5), GH1(3), GHR(20), HRAS(3), IGF1(9), IGF1R(9), PIK3CA(6), PIK3R1(3), SHC1(1)	4379468	62	48	59	33	41	9	0	8	3	1	0.609	1.000	1.000
492	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(17), AXIN1(9), BTRC(4), CTNNB1(11), DLL1(2), DVL1(1), FZD1(4), GSK3B(2), NOTCH1(5), PSEN1(1), WNT1(1)	6953227	58	48	58	35	28	7	4	5	14	0	0.882	1.000	1.000
493	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(2), IL6R(4), JAK1(5), JAK2(7), JAK3(4), PIAS3(5), PTPRU(13), REG1A(6), SRC(1), STAT3(10)	5011621	59	48	59	37	31	6	2	11	9	0	0.779	1.000	1.000
494	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(11), FADS2(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8)	3343640	64	47	64	33	44	4	1	5	10	0	0.244	1.000	1.000
495	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(4), LCMT1(3), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	4982218	61	47	61	28	34	9	2	12	4	0	0.265	1.000	1.000
496	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), KLK2(1), MAP2K1(11), MAPK3(1), MAPK8(1), NGFR(6), PIK3CA(6), PIK3R1(3), PLCG1(7), RAF1(7), SHC1(1), SOS1(7)	6276583	62	47	57	27	32	7	2	15	5	1	0.560	1.000	1.000
497	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(18), ACACB(15), FASN(15), MCAT(2), OLAH(8), OXSM(1)	5215892	59	46	58	32	34	5	3	9	8	0	0.416	1.000	1.000
498	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(6), IL22(1), IL22RA1(8), JAK1(5), JAK2(7), JAK3(4), SOCS3(2), STAT1(3), STAT3(10), STAT5A(2), STAT5B(4), TYK2(7)	6006878	59	46	59	40	26	6	6	14	7	0	0.941	1.000	1.000
499	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(4), CHUK(2), IFNG(1), IKBKB(3), IL2(2), IL4(1), JUN(1), MAP3K1(2), MAP3K5(15), MAP4K5(2), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(3), TNFSF9(1), TRAF2(1)	6320955	57	45	54	30	32	4	1	12	8	0	0.734	1.000	1.000
500	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(15), GFPT1(4), GNE(3), HEXA(4), HEXB(3), HK1(3), HK2(11), HK3(12), PGM3(1), RENBP(3), UAP1(2)	5607415	62	45	61	31	40	5	2	8	7	0	0.360	1.000	1.000
501	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(1), CCR5(6), CXCL12(2), CXCR4(3), FOS(2), GNAQ(4), JUN(1), MAPK14(5), MAPK8(1), PLCG1(7), PRKCA(10), PTK2B(8), SYT1(17)	4570191	69	45	64	46	44	6	4	10	5	0	0.743	1.000	1.000
502	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(1), HRAS(3), MAPK1(4), MAPK3(1), MAPK7(3), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), NTRK1(12), PIK3CA(6), PIK3R1(3), PLCG1(7), RPS6KA1(6), SHC1(1)	6232179	62	45	60	45	35	10	2	7	7	1	0.963	1.000	1.000
503	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(5), ACADS(4), ACADVL(1), ACSL1(4), ACSL3(5), ACSL4(2), CPT1A(9), CPT2(1), DCI(2), EHHADH(5), HADHA(8), PECR(1), SCP2(2), SLC25A20(1)	5612162	54	45	53	24	35	3	3	7	6	0	0.464	1.000	1.000
504	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), FDXR(7), SHMT1(1)	5299552	69	45	68	38	37	4	6	13	9	0	0.486	1.000	1.000
505	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(5), JAK2(7), JAK3(4), PIAS1(4), PIAS3(5), PTPRU(13), REG1A(6), SOAT1(3)	4508699	49	45	49	27	30	4	1	7	7	0	0.613	1.000	1.000
506	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(2), CHUK(2), GH1(3), GHR(20), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RELA(4)	4615538	57	44	54	33	36	6	3	8	3	1	0.824	1.000	1.000
507	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(6), GBF1(10), GPLD1(15), KDELR3(1)	5418590	56	44	56	35	29	4	4	13	6	0	0.880	1.000	1.000
508	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1)	4981708	62	44	61	35	33	3	6	12	8	0	0.560	1.000	1.000
509	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1)	4981708	62	44	61	35	33	3	6	12	8	0	0.560	1.000	1.000
510	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(4), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), IDS(9), IDUA(4), LCT(29), NAGLU(4)	4719648	70	44	70	40	54	4	0	8	4	0	0.540	1.000	1.000
511	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(6), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(1), EHHADH(5), ESCO1(1), ESCO2(2), GCDH(5), HADHA(8), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2), YOD1(1)	8625866	73	44	72	45	40	9	3	16	5	0	0.934	1.000	1.000
512	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(31), CYP2C9(30)	666729	61	44	53	44	50	3	2	1	5	0	0.795	1.000	1.000
513	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(5), BCL2(2), CASP3(2), CASP9(2), CYCS(1), DAXX(8), FAS(5), FASLG(12), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(5), MAPKAPK3(3), TNF(1)	3762030	55	44	55	26	32	4	3	8	8	0	0.325	1.000	1.000
514	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(19), HSD17B2(7), HSD17B3(3), HSD17B4(6), HSD17B7(1), HSD3B1(10), HSD3B2(7)	2642634	59	44	54	28	40	4	4	4	6	1	0.206	1.000	1.000
515	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1)	4981708	62	44	61	35	33	3	6	12	8	0	0.560	1.000	1.000
516	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(26), MAP2(11), PPP2CA(1), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4), PRKCE(5)	5974126	61	43	60	38	36	6	4	7	8	0	0.955	1.000	1.000
517	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CAMKK1(2), CAMKK2(6), SYT1(17)	3837996	59	43	54	48	42	6	2	5	4	0	0.920	1.000	1.000
518	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(29), MPI(1), PGM1(4), PYGL(6), PYGM(9), TREH(2)	4354958	54	43	54	44	41	5	1	5	2	0	0.801	1.000	1.000
519	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(5), B3GALNT1(5), B3GALT5(1), FUT1(3), FUT2(3), FUT9(22), GBGT1(1), GLA(1), HEXA(4), HEXB(3), NAGA(3), ST3GAL1(5), ST3GAL2(1), ST8SIA1(1)	3545685	58	43	57	29	36	6	3	9	4	0	0.250	1.000	1.000
520	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(14), EGFR(17), ERBB3(4), NRG1(15), UBE2D1(1)	3416290	51	42	51	35	37	1	3	7	3	0	0.972	1.000	1.000
521	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10L(4), RPL11(2), RPL13A(1), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS27(1), RPS29(1), RPS3A(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1)	7437620	56	42	56	38	29	4	7	10	6	0	0.882	1.000	1.000
522	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(11), CDC25A(7), CDC25B(4), CDC25C(2), CHEK1(1), MYT1(19), WEE1(2)	4552047	46	41	45	21	27	5	1	6	7	0	0.588	1.000	1.000
523	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(1), HEMK1(4), LCMT1(3), METTL2B(7), METTL6(2), PCYT1A(3), PCYT1B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	4641616	54	41	54	22	29	7	4	10	4	0	0.181	1.000	1.000
524	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(7), CHST2(3), CHST4(8), CHST6(3), FUT8(7), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	4108493	51	41	50	34	32	11	4	2	2	0	0.588	1.000	1.000
525	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(11), AMT(1), ATIC(5), FTCD(2), GART(9), MTFMT(1), MTHFD1(9), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(1), SHMT2(2), TYMS(1)	6263966	52	41	51	30	36	4	3	6	3	0	0.640	1.000	1.000
526	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(6), CLOCK(4), CRY1(5), CRY2(3), CSNK1D(1), CSNK1E(2), NPAS2(4), PER1(7), PER2(8), PER3(9)	5616530	49	41	46	37	31	5	1	4	8	0	0.974	1.000	1.000
527	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), SDS(2)	4003888	48	41	46	25	25	8	2	9	4	0	0.391	1.000	1.000
528	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(17), EP300(13), HDAC3(5), IKBKB(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF6(4)	7363190	64	41	64	30	37	6	5	12	4	0	0.551	1.000	1.000
529	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(6), JAK1(5), PTPRU(13), REG1A(6), STAT1(3), STAT2(5), TYK2(7)	4141969	47	41	47	24	25	3	2	9	8	0	0.463	1.000	1.000
530	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(3), MAPK14(5), MAPK8(1), NFKB1(7), RELA(4), TNFRSF13B(6), TNFRSF17(5), TNFSF13B(1), TRAF2(1), TRAF3(5), TRAF5(6), TRAF6(4)	4743145	50	41	49	21	31	6	0	11	2	0	0.297	1.000	1.000
531	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(15), AOC2(7), AOC3(8), CES1(16), ESD(1)	1987022	47	40	45	30	38	2	3	2	2	0	0.551	1.000	1.000
532	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(5), IL4(1), IL5(2), MAF(1), MAP2K3(7), MAPK14(5), NFATC1(13), NFATC2(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	3978166	59	40	58	41	40	5	3	5	6	0	0.767	1.000	1.000
533	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(1), HRAS(3), KLK2(1), NTRK1(12), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), SHC1(1), SOS1(7)	5131802	55	40	54	26	30	8	2	9	5	1	0.593	1.000	1.000
534	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL15(3), IL16(10), IL18(2), IL1A(4), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL8(1), IL9(1), LTA(1), TNF(1)	3260886	46	38	46	28	30	1	3	4	8	0	0.387	1.000	1.000
535	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(5), ARHGAP5(10), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP8(7), CASP9(2), CYCS(1), GZMB(2), JUN(1), PRF1(7)	4275626	44	38	43	25	25	5	3	8	3	0	0.854	1.000	1.000
536	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(14), EGFR(17), HGS(3), RAB5A(1), TF(10), TFRC(4)	4240903	51	38	51	35	35	2	4	7	3	0	0.951	1.000	1.000
537	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(4), EPO(5), EPOR(1), GRIN1(5), HIF1A(5), JAK2(7), NFKB1(7), NFKBIA(2), RELA(4)	4136534	47	38	47	21	19	5	4	10	9	0	0.568	1.000	1.000
538	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(7), FDPS(3), GGCX(3), GGPS1(1), HMGCR(11), HSD17B7(1), IDI1(1), IDI2(1), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(2), SQLE(3), TM7SF2(3)	6367089	48	38	46	23	18	9	4	10	7	0	0.443	1.000	1.000
539	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(6), HDAC9(32), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1)	2443516	53	38	46	27	40	5	0	3	5	0	0.437	1.000	1.000
540	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(11), AMT(1), ATIC(5), GART(9), MTHFD1(9), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(1), SHMT2(2), TYMS(1)	5914775	49	38	48	25	34	4	3	6	2	0	0.411	1.000	1.000
541	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(6), CTH(1), GGT1(4), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), PAPSS1(2), PAPSS2(5), SCLY(3), SEPHS1(4)	4124862	44	38	44	19	25	4	3	7	5	0	0.184	1.000	1.000
542	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(10), CYP2E1(12), NR1I3(6), PTGS1(14), PTGS2(9)	1783044	51	37	50	27	36	4	1	4	6	0	0.201	1.000	1.000
543	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(17), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10)	3121026	49	37	47	34	37	4	2	2	4	0	0.917	1.000	1.000
544	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(1), IL10(3), IL10RA(6), IL10RB(5), IL1A(4), IL6(2), JAK1(5), STAT1(3), STAT3(10), STAT5A(2), TNF(1)	4034884	44	37	43	23	18	5	6	7	8	0	0.485	1.000	1.000
545	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(17), EP300(13), ESR1(5), MAPK1(4), MAPK3(1), PELP1(9), SRC(1)	4842523	50	37	50	25	32	3	3	9	3	0	0.644	1.000	1.000
546	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(5), IKBKB(3), LTA(1), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNFAIP3(1), TNFRSF1B(3), TRAF1(5), TRAF2(1), TRAF3(5)	7357740	45	37	45	40	28	6	1	6	4	0	0.995	1.000	1.000
547	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(1), OPRK1(19), POLR2A(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	4235756	52	36	52	46	39	3	3	3	4	0	0.969	1.000	1.000
548	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(8), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(10), PON3(1), RDH11(2), RDH12(2), RDH13(3)	2989709	46	36	45	24	31	4	1	6	4	0	0.323	1.000	1.000
549	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(4), AFMID(2), CS(2), GRHPR(2), HAO1(5), HAO2(9), HYI(1), MDH1(1), MDH2(3), MTHFD1(9), MTHFD1L(1), MTHFD2(1)	4429226	45	36	42	23	25	4	4	6	6	0	0.387	1.000	1.000
550	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(1), GOSR1(1), GOSR2(1), SEC22B(4), SNAP25(5), SNAP29(1), STX10(1), STX11(1), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(2), STX5(4), STX6(1), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(4), VAMP8(1), VTI1A(1), VTI1B(1)	5464208	48	36	46	22	25	5	2	9	7	0	0.354	1.000	1.000
551	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL2RG(2), IL4(1), IL4R(12), IRS1(5), JAK1(5), JAK3(4), RPS6KB1(2), SHC1(1), STAT6(7)	4870795	43	36	43	24	22	6	3	5	7	0	0.628	1.000	1.000
552	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(9), CDO1(5), CSAD(3), GAD1(12), GAD2(7), GGT1(4)	1868778	40	35	39	22	26	4	4	4	2	0	0.442	1.000	1.000
553	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(15), HK1(3), HK2(11), HK3(12), IMPA1(1), IMPA2(2), PGM1(4), PGM3(1), TGDS(1)	3847850	50	35	49	31	36	5	1	3	5	0	0.502	1.000	1.000
554	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(3), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(1), NFKB1(7), RELA(4), TNFRSF11A(3), TNFSF11(3), TRAF6(4)	3658339	42	35	42	23	27	3	0	8	4	0	0.729	1.000	1.000
555	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(10), MBTPS1(8), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(7)	3916090	40	35	38	20	23	2	3	8	4	0	0.457	1.000	1.000
556	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(5), IKBKB(3), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(1), TRAF3(5), TRAF6(4)	5959104	38	34	38	31	23	6	1	6	2	0	0.985	1.000	1.000
557	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(4), CS(2), GRHPR(2), HAO1(5), HAO2(9), HYI(1), MDH1(1), MDH2(3), MTHFD1(9), MTHFD1L(1), MTHFD2(1)	4228787	43	34	40	19	24	4	3	6	6	0	0.234	1.000	1.000
558	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(5), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(5), SULT1A1(8), SULT1A2(2), SULT1E1(10), SULT2A1(6), SULT2B1(5), SUOX(3)	3008192	51	34	49	30	40	2	0	4	5	0	0.482	1.000	1.000
559	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(15), CKM(2), FBL(1), GPT(3), LDHA(4), LDHB(2), LDHC(5), MAPK14(5), NCL(6)	2969921	43	34	42	20	30	2	4	4	3	0	0.329	1.000	1.000
560	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(3), IL4R(12), JAK1(5), JAK2(7), TYK2(7)	3455250	37	34	37	17	22	1	1	8	5	0	0.583	1.000	1.000
561	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(1), IFNGR1(4), JAK1(5), JAK2(7), PLA2G2A(2), PTPRU(13), REG1A(6), STAT1(3)	3771205	43	34	43	21	24	2	0	8	9	0	0.606	1.000	1.000
562	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(3), IL4R(12), JAK1(5), JAK2(7), TYK2(7)	3455250	37	34	37	17	22	1	1	8	5	0	0.583	1.000	1.000
563	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), XYLT1(8), XYLT2(3)	2093810	37	33	37	31	23	5	1	5	3	0	0.824	1.000	1.000
564	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), XYLT1(8), XYLT2(3)	2093810	37	33	37	31	23	5	1	5	3	0	0.824	1.000	1.000
565	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(15), HK1(3), HK2(11), HK3(12), IMPA1(1), PGM1(4), PGM3(1), TGDS(1)	3382328	48	33	47	26	35	5	1	3	4	0	0.337	1.000	1.000
566	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(4), FOS(2), FYN(5), JUN(1), MAPK14(5), THBS1(21)	2446867	40	32	40	20	23	1	2	6	8	0	0.610	1.000	1.000
567	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(24), GNAS(17), PRKACA(3), PRKAR1A(1)	2142082	45	31	44	23	28	5	3	4	5	0	0.368	1.000	1.000
568	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2)	5506878	46	31	46	34	24	6	1	11	4	0	0.991	1.000	1.000
569	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(17), GNA12(3), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4)	3333743	38	30	38	20	26	3	1	5	3	0	0.575	1.000	1.000
570	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3)	5340030	39	30	38	18	22	4	2	8	3	0	0.620	1.000	1.000
571	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(5), STAT1(3), STAT2(5), TYK2(7)	3561135	36	30	36	16	18	2	2	9	5	0	0.471	1.000	1.000
572	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(8), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(9), PPP2CA(1)	2969661	32	29	32	15	20	2	2	3	5	0	0.367	1.000	1.000
573	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2)	2625032	32	28	31	19	16	6	2	5	3	0	0.553	1.000	1.000
574	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2)	2625032	32	28	31	19	16	6	2	5	3	0	0.553	1.000	1.000
575	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(7), FDPS(3), HMGCR(11), IDI1(1), MVD(1), MVK(2), NQO1(1), PMVK(1), SC5DL(2), SQLE(3)	3640106	32	28	30	14	11	4	2	10	5	0	0.515	1.000	1.000
576	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(17), EIF2AK4(10), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(2)	3849317	33	28	29	14	12	1	1	12	7	0	0.843	1.000	1.000
577	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(3), IDH1(11), IDH2(2), MDH1(1), MDH2(3)	4423490	43	28	34	19	30	0	2	7	4	0	0.184	1.000	1.000
578	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), LTB4R(1), P2RY1(4), P2RY2(7), P2RY6(1)	1968108	32	28	32	23	19	5	0	5	3	0	0.245	1.000	1.000
579	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(5), JAK2(7), JAK3(4), MAPK1(4), MAPK3(1), STAT3(10), TYK2(7)	3841492	38	28	38	26	16	5	2	8	7	0	0.903	1.000	1.000
580	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(4), CD3G(1), IFNG(1), IL2(2), IL2RA(3), IL4(1), TGFB1(1), TGFB3(3), TGFBR2(7), TGFBR3(6), TOB1(2), TOB2(1)	3477736	33	28	33	23	25	2	0	1	5	0	0.791	1.000	1.000
581	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(3), NRF1(4), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2J2(4), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(5)	3499172	32	28	32	16	19	5	1	5	2	0	0.675	1.000	1.000
582	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), MIOX(2), UGDH(1)	2795171	31	27	29	21	14	7	4	3	3	0	0.739	1.000	1.000
583	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(2), ESR1(5), GREB1(13), HSPB1(2), HSPB2(1), MTA1(1), MTA3(2), PDZK1(3), TUBA8(3)	3518573	33	27	33	22	25	0	3	4	1	0	0.654	1.000	1.000
584	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(7), CDC25B(4), CDC25C(2), CSK(1), GRB2(1), PRKCA(10), PTPRA(6), SRC(1)	3074133	32	27	31	20	19	6	1	4	2	0	0.734	1.000	1.000
585	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(3), GPI(3), HK1(3), PFKL(4), PGK1(4), PKLR(8)	3029886	34	26	31	16	21	4	1	4	4	0	0.123	1.000	1.000
586	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(5), CPS1(17), GLS(1), GLUD1(1), GOT1(3)	2523415	28	26	28	16	17	1	2	6	2	0	0.709	1.000	1.000
587	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(5)	4299016	33	25	33	14	17	4	1	8	3	0	0.548	1.000	1.000
588	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(6), CLOCK(4), CRY1(5), CRY2(3), CSNK1E(2), PER1(7)	2789603	27	24	26	14	15	3	1	3	5	0	0.735	1.000	1.000
589	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(1), ACAT2(1), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), SDS(2)	2765943	26	24	25	13	15	3	1	4	3	0	0.609	1.000	1.000
590	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(3), GBA3(14), GGT1(4), SHMT1(1), SHMT2(2)	1769501	26	24	24	15	19	1	0	3	3	0	0.408	1.000	1.000
591	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(4), B3GALT1(9), B3GALT2(1), B3GALT5(1), FUT1(3), FUT2(3), FUT3(4), ST3GAL3(1), ST3GAL4(1)	2368254	27	24	27	20	20	3	0	3	1	0	0.740	1.000	1.000
592	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(7), PLCG1(7), PRKCA(10), PTK2B(8)	2234632	32	24	31	21	23	3	1	2	3	0	0.498	1.000	1.000
593	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(22), RANGAP1(3)	2819019	26	24	26	11	17	2	1	3	3	0	0.651	1.000	1.000
594	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), ADSS(2), IMPDH1(2), MTHFD2(1), POLD1(6), POLG(6), PRPS2(3), RRM1(3)	4101930	26	23	26	23	16	0	1	5	4	0	0.979	1.000	1.000
595	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(7), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	2594733	25	22	25	15	13	6	3	2	1	0	0.687	1.000	1.000
596	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(7), CDC25B(4), CDC25C(2), MNAT1(2), SHH(4), XPO1(2)	2888586	23	22	23	11	12	3	2	5	1	0	0.674	1.000	1.000
597	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(4), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(1), HBB(4), HMBS(1), UROS(1)	2522927	22	21	22	17	17	1	0	1	3	0	0.807	1.000	1.000
598	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(14), GGT1(4), SHMT1(1), SHMT2(2)	1340428	21	21	19	14	15	1	0	3	2	0	0.518	1.000	1.000
599	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(3), HMGCL(3), HMGCS1(1), HMGCS2(16), OXCT1(4), OXCT2(2)	2361155	30	21	29	20	18	5	0	5	2	0	0.879	1.000	1.000
600	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(4), FUT1(3), FUT2(3), FUT3(4), FUT5(4), FUT6(4), ST3GAL3(1)	1648452	23	20	23	16	13	3	1	2	4	0	0.507	1.000	1.000
601	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), HBXIP(1), HRAS(3), PTK2B(8), SHC1(1), SOS1(7), SRC(1)	2908172	22	19	22	20	14	2	0	4	2	0	0.991	1.000	1.000
602	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3)	1594295	22	19	22	17	15	1	2	1	3	0	0.763	1.000	1.000
603	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(4), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(10), SDHA(1)	3134522	23	19	22	15	14	0	2	3	4	0	0.806	1.000	1.000
604	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(7), IL1B(6), MST1(1), MST1R(5), TNF(1)	2162875	21	19	20	20	15	2	1	0	3	0	0.947	1.000	1.000
605	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(18), PNPO(1), PSAT1(1)	1609765	20	18	20	18	16	1	1	2	0	0	0.948	1.000	1.000
606	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(4), IFNGR2(4), JAK1(5), JAK2(7), STAT1(3)	2697873	24	18	22	10	7	1	0	7	9	0	0.900	1.000	1.000
607	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(7), IL6(2), LDLR(10), LPL(3)	1772401	23	18	23	13	14	3	2	3	1	0	0.519	1.000	1.000
608	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(1), APOBEC3C(2), APOBEC3F(3), APOBEC3G(2)	2445919	18	17	18	24	12	2	3	1	0	0	0.998	1.000	1.000
609	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(1), CD3D(4), CD3G(1), CD4(6)	1059590	18	15	18	14	11	3	0	3	1	0	0.728	1.000	1.000
610	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ5(2), COQ6(1), COQ7(2), NDUFA12(1), NDUFA13(6)	1316053	13	13	12	9	11	1	1	0	0	0	0.831	1.000	1.000
611	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(5), NOTCH1(5), PSEN1(1)	3036240	14	13	14	16	7	3	1	3	0	0	0.972	1.000	1.000
612	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), HGD(10)	743976	12	12	12	16	8	2	2	0	0	0	0.987	1.000	1.000
613	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(5), ARG1(1), GLS(1), GLUD1(1), OAT(2), PRODH(1)	1797831	11	10	11	12	3	4	1	2	1	0	0.984	1.000	1.000
614	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4)	1631058	9	9	9	10	4	0	1	0	4	0	0.987	1.000	1.000
615	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(3)	1406766	9	9	9	5	5	1	1	2	0	0	0.672	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3)	703495	3	3	3	4	2	0	0	1	0	0	0.951	1.000	1.000
