(primary solid tumor cohort)
-
MAF used for this analysis:BLCA-TP.final_analysis_set.maf
-
Significantly mutated genes (q ≤ 0.1): 21
Column Descriptions:
-
N = number of sequenced bases in this gene across the individual set
-
nnon = number of (nonsilent) mutations in this gene across the individual set
-
nnull = number of (nonsilent) null mutations in this gene across the individual set
-
nflank = number of noncoding mutations from this gene's flanking region, across the individual set
-
nsil = number of silent mutations in this gene across the individual set
-
p = p-value (overall)
-
q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 21. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| TP53 | 3528 | 0 | 1 | 14 | 3 | 0 | 0 |
| KDM6A | 12769 | 1 | 2 | 6 | 6 | 1.6e-132 | 1.5e-128 |
| ARID1A | 16296 | 0 | 1 | 8 | 5 | 6.9e-54 | 4.3e-50 |
| ASXL2 | 12589 | 0 | 0 | 6 | 2 | 2.3e-18 | 1.1e-14 |
| FLG | 30575 | 0 | 1 | 8 | 0 | 1.3e-15 | 5e-12 |
| HRNR | 15146 | 0 | 0 | 6 | 0 | 2.2e-15 | 7e-12 |
| TTN | 357098 | 1 | 3 | 34 | 4 | 2.6e-14 | 6.9e-11 |
| RPAP1 | 10651 | 0 | 0 | 5 | 0 | 1.9e-11 | 4.5e-08 |
| FBXW7 | 8047 | 0 | 0 | 6 | 2 | 4.3e-11 | 8.9e-08 |
| MLL | 36311 | 0 | 1 | 9 | 2 | 1.2e-10 | 2.3e-07 |
| GOLGB1 | 34742 | 0 | 2 | 12 | 3 | 1.7e-10 | 3e-07 |
| ADAMTS12 | 15260 | 0 | 1 | 4 | 0 | 8.8e-10 | 1.4e-06 |
| DCC | 13602 | 0 | 1 | 5 | 0 | 4e-09 | 5.8e-06 |
| MLL2 | 34764 | 0 | 0 | 6 | 6 | 2.5e-08 | 0.000034 |
| MACF1 | 85714 | 2 | 0 | 9 | 1 | 1.2e-07 | 0.00015 |
| PRX | 9460 | 0 | 0 | 9 | 1 | 1.8e-07 | 0.00021 |
| ABCA10 | 17600 | 1 | 0 | 5 | 2 | 4.6e-07 | 0.00051 |
| HCN1 | 8148 | 1 | 1 | 5 | 3 | 2e-06 | 0.0021 |
| SPTA1 | 24718 | 0 | 0 | 5 | 0 | 0.000024 | 0.024 |
| APOB | 49173 | 0 | 0 | 6 | 0 | 3e-05 | 0.029 |
| TPR | 26207 | 1 | 1 | 5 | 0 | 0.000044 | 0.039 |
| BCLAF1 | 9083 | 0 | 0 | 5 | 1 | 0.00026 | 0.23 |
| HMCN1 | 55209 | 3 | 0 | 9 | 2 | 0.00028 | 0.23 |
| DNAH5 | 49325 | 0 | 1 | 7 | 1 | 0.00032 | 0.25 |
| SACS | 47870 | 0 | 2 | 6 | 2 | 0.00091 | 0.69 |
| OTUD7A | 4967 | 0 | 0 | 4 | 0 | 0.0012 | 0.86 |
| XPR1 | 7476 | 0 | 1 | 5 | 2 | 0.0014 | 1 |
| SPATS2 | 5365 | 0 | 0 | 4 | 1 | 0.0019 | 1 |
| KPNA3 | 5639 | 1 | 0 | 4 | 1 | 0.0026 | 1 |
| NFE2L2 | 6020 | 0 | 0 | 4 | 0 | 0.004 | 1 |
| MLL3 | 45342 | 0 | 0 | 7 | 2 | 0.0066 | 1 |
| ERCC2 | 7666 | 0 | 0 | 4 | 0 | 0.012 | 1 |
| SYNE1 | 91835 | 0 | 3 | 8 | 1 | 0.012 | 1 |
| FGA | 8013 | 0 | 0 | 4 | 0 | 0.015 | 1 |
| CUL1 | 8607 | 0 | 0 | 4 | 0 | 0.02 | 1 |
