rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6), TYR(4) 7428057 20 20 20 2 6 2 5 3 4 0 0.0670 0.0184 1.000 2 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8) 4432701 12 12 12 0 2 1 3 4 2 0 0.0401 0.0218 1.000 3 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT1(1), B3GALT2(1), B3GALT5(1), FUT2(2), FUT3(4), ST3GAL3(1), ST3GAL4(1) 5407662 15 15 14 2 4 5 2 2 2 0 0.0496 0.0332 1.000 4 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), CREM(2), FHL5(1), FSHR(4), GNAS(5), XPO1(3) 6833346 18 18 18 2 4 4 3 5 2 0 0.134 0.0415 1.000 5 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT2(2), FUT3(4), FUT5(1), ST3GAL3(1) 3810105 12 12 11 2 4 3 1 2 2 0 0.0958 0.0640 1.000 6 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(5), MPO(2), TPO(6) 6402396 14 14 14 0 6 1 2 2 3 0 0.0124 0.0791 1.000 7 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(4), ALDOB(2), TPI1(2) 2928939 8 8 8 0 0 4 3 0 1 0 0.0508 0.0865 1.000 8 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(2), CBS(2), CTH(3), MUT(1) 3739125 8 8 8 0 1 1 1 1 4 0 0.136 0.116 1.000 9 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6) 9083412 17 17 17 1 7 1 2 3 4 0 0.0364 0.154 1.000 10 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1) 8374626 16 16 16 2 2 6 3 3 2 0 0.115 0.154 1.000 11 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNB1(1), HTR2C(1), PLCB1(4), TUB(2) 5413746 11 11 11 1 3 1 5 1 1 0 0.198 0.164 1.000 12 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1) 4319640 9 9 9 1 1 3 2 2 1 0 0.180 0.176 1.000 13 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX5(1), CBR1(1), CBR3(1), CYP4F2(1), EPX(1), GGT1(1), LPO(5), MPO(2), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(6) 21581976 42 40 40 3 9 5 14 7 7 0 0.00127 0.210 1.000 14 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(3) 1313637 3 3 3 1 2 0 0 0 1 0 0.795 0.220 1.000 15 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(1) 894855 2 2 2 0 0 1 0 1 0 0 0.505 0.241 1.000 16 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD3G(1), CD4(2), CD8A(1), IL6(2), KITLG(2) 4752618 12 12 12 3 0 3 4 2 3 0 0.471 0.248 1.000 17 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(1), LCT(6), PGM1(2), PYGL(1), PYGM(4), TPI1(2), TREH(1) 10340265 18 18 18 1 3 1 3 5 6 0 0.0427 0.271 1.000 18 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), EPX(1), LPO(5), MPO(2), TPO(6) 8813181 15 15 15 1 7 1 2 2 3 0 0.0486 0.284 1.000 19 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12A(1), IL12B(1), IL2(1) 2357043 4 4 4 1 0 0 0 3 1 0 0.819 0.293 1.000 20 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 549588 1 1 1 1 0 0 0 0 1 0 0.920 0.310 1.000 21 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), HSD17B1(1), HSD17B2(1), HSD17B4(4), HSD3B2(3) 6183372 10 10 10 1 2 1 5 1 1 0 0.289 0.339 1.000 22 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(4), ATM(12), BRCA1(8), CHEK2(2), JUN(1), MAPK8(2), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(2), RAD51(1), RELA(1), TP73(1) 21611382 39 36 39 4 5 6 6 7 15 0 0.0297 0.354 1.000 23 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), GAD1(2), GAD2(3), GGT1(1) 4423575 8 8 8 0 2 2 3 1 0 0 0.0681 0.365 1.000 24 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CDK2(1), CUL1(1), E2F1(2), FBXW7(2), TFDP1(1) 5158725 8 8 8 1 4 0 1 2 1 0 0.272 0.366 1.000 25 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(3), CYP17A1(1), HSD11B1(2), HSD3B2(3) 5225142 11 11 11 2 1 0 7 3 0 0 0.397 0.394 1.000 26 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(3) 11018631 20 20 20 3 0 1 13 4 2 0 0.328 0.401 1.000 27 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 APAF1(1), ATM(12), BAD(1), BID(4), CASP6(2), EIF2S1(1), PTK2(3), PXN(1), STAT1(1), TLN1(9) 19787196 35 33 35 3 4 10 5 4 12 0 0.0158 0.401 1.000 28 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 1678677 3 3 3 1 1 0 0 2 0 0 0.753 0.403 1.000 29 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 6 CCL11(1), CCR3(1) 1563588 2 2 2 0 0 1 0 0 1 0 0.573 0.408 1.000 30 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(1), CDK2(1), E2F1(2), MDM2(2), PRB1(1) 5275842 8 8 8 1 4 1 1 1 1 0 0.247 0.418 1.000 31 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), FBL(2), LDHC(1), MAPK14(1), NCL(2) 6997107 10 10 10 1 3 3 2 1 1 0 0.135 0.424 1.000 32 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 1214772 2 2 2 0 0 0 1 0 1 0 0.550 0.430 1.000 33 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(3), CPS1(5), GLS(1) 5934435 11 11 11 2 1 2 4 3 1 0 0.362 0.432 1.000 34 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(1), RAB3A(1), RAB6A(1) 3309189 5 5 5 0 0 0 2 0 3 0 0.388 0.435 1.000 35 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1) 4275531 5 5 5 1 2 1 2 0 0 0 0.517 0.461 1.000 36 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(1) 2421432 4 4 4 0 1 0 3 0 0 0 0.322 0.468 1.000 37 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(1), HSD11B1(2), HSD3B2(3) 7330206 14 14 14 2 2 1 9 2 0 0 0.212 0.471 1.000 38 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(1), HSD11B1(2), HSD3B2(3) 7330206 14 14 14 2 2 1 9 2 0 0 0.212 0.471 1.000 39 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 4 PLCB1(4), PLCG1(5), VAV1(2) 6266520 11 11 11 2 4 2 2 0 3 0 0.311 0.473 1.000 40 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BAK1(1), BID(4), CASP6(2), CASP8(3), DFFB(2) 10306803 13 13 13 1 2 6 0 1 4 0 0.0837 0.474 1.000 41 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(1), PCYT1A(1), PDHA1(2), PDHA2(2), SLC18A3(2) 5192187 9 9 9 1 2 4 3 0 0 0 0.103 0.475 1.000 42 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 17 BCR(1), CRKL(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), MYC(1), RAF1(1), SOS1(4), STAT1(1), STAT5A(3), STAT5B(4) 14637090 27 27 27 4 6 4 3 4 10 0 0.0700 0.479 1.000 43 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 10 CCNE1(1), CDK2(1), CUL1(1), E2F1(2), NEDD8(1), TFDP1(1) 4989894 7 7 7 1 3 0 2 1 1 0 0.370 0.517 1.000 44 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UXS1(2) 3062280 5 4 5 0 1 2 1 1 0 0 0.193 0.517 1.000 45 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PNPO(2) 3656484 5 5 5 1 0 0 3 1 1 0 0.622 0.519 1.000 46 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 1160523 1 1 1 0 0 0 0 0 1 0 0.885 0.530 1.000 47 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(3) 2888379 3 3 3 0 0 1 0 1 1 0 0.417 0.545 1.000 48 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(2), MYC(1), SP1(2), SP3(3), WT1(1) 4504695 11 10 11 3 1 2 1 4 3 0 0.588 0.549 1.000 49 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3) 10289565 18 16 18 3 2 8 5 2 1 0 0.102 0.562 1.000 50 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CES1(2) 8892780 11 11 11 1 3 4 1 1 2 0 0.179 0.566 1.000 51 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), IDS(3), IDUA(2), LCT(6), NAGLU(1) 11059191 19 17 19 2 4 4 4 6 1 0 0.0586 0.573 1.000 52 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA2(2), CCND1(1), CCNE1(1), CDK2(1), E2F1(2), E2F4(2), PRB1(1) 6473883 10 10 10 2 4 1 0 2 3 0 0.407 0.574 1.000 53 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), MYT1(2), WEE1(1) 10634325 20 19 20 3 3 4 5 3 5 0 0.160 0.576 1.000 54 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(2), JAK2(5), STAT1(1) 6277167 8 8 8 1 0 0 2 2 4 0 0.650 0.579 1.000 55 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4) 8002995 16 15 15 3 1 1 6 5 3 0 0.429 0.579 1.000 56 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4) 8002995 16 15 15 3 1 1 6 5 3 0 0.429 0.579 1.000 57 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3) 9797268 18 16 18 3 2 8 5 2 1 0 0.105 0.583 1.000 58 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1) 5507034 7 7 7 1 3 1 1 1 1 0 0.393 0.599 1.000 59 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), CDK2(1), MYT1(2), WEE1(1) 11579880 21 20 21 3 3 4 5 3 6 0 0.159 0.605 1.000 60 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(5), JAK3(2), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4), TYK2(4) 14153919 26 25 25 4 7 0 7 4 8 0 0.135 0.606 1.000 61 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(4), RELA(1) 6248268 8 8 8 1 2 2 2 0 2 0 0.298 0.612 1.000 62 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(5), PTK2B(3) 5095350 9 9 9 2 1 3 3 0 2 0 0.329 0.618 1.000 63 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(1), UBE2D2(2), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(1), UBE3A(1) 8021754 11 11 11 1 0 4 4 0 3 0 0.275 0.618 1.000 64 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3E(1), CD3G(1), CD4(2) 2491905 5 5 5 2 0 2 1 1 1 0 0.708 0.620 1.000 65 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CDK7(2), MNAT1(1), XPO1(3) 6544356 13 13 13 3 2 2 7 1 1 0 0.563 0.628 1.000 66 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 16 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMB8(1) 6059664 8 8 8 0 1 1 3 2 1 0 0.109 0.630 1.000 67 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(1), BCMO1(4), RDH5(2) 2952768 9 9 9 6 1 1 4 0 3 0 0.953 0.635 1.000 68 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(3), LRP8(1), RELN(13), VLDLR(3) 10644465 21 20 20 4 4 3 8 3 3 0 0.237 0.640 1.000 69 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT2(1), TYR(4) 3565224 6 6 6 2 0 2 4 0 0 0 0.724 0.641 1.000 70 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1298427 1 1 1 1 1 0 0 0 0 0 0.934 0.642 1.000 71 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(2), P2RY1(2), P2RY2(1), P2RY6(1) 4208607 7 7 7 2 2 2 1 2 0 0 0.395 0.655 1.000 72 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), ATM(12), CCND1(1), CCNE1(1), CDK2(1), E2F1(2), MDM2(2) 11873940 20 19 20 3 5 4 2 3 6 0 0.130 0.656 1.000 73 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(3), SNCAIP(3) 4820049 8 8 8 2 1 2 4 1 0 0 0.606 0.657 1.000 74 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(1), FOSB(1), GRIA2(1) 2738307 3 3 3 1 0 1 1 1 0 0 0.689 0.664 1.000 75 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), PANK2(1), PANK4(3), UPB1(3) 10425441 21 20 21 4 2 3 5 6 5 0 0.324 0.672 1.000 76 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UXS1(2) 3856749 5 4 5 0 1 2 1 1 0 0 0.197 0.681 1.000 77 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(1), SP1(2), SP3(3) 3707691 7 7 7 2 0 1 0 3 3 0 0.747 0.682 1.000 78 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNE1(1), CDK2(1), CUL1(1), E2F1(2), TFDP1(1) 5331612 6 6 6 1 3 0 1 1 1 0 0.408 0.686 1.000 79 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(3), JUN(1), PRF1(2) 9735414 12 12 12 2 2 2 1 3 4 0 0.327 0.686 1.000 80 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(2), STAT1(1), STAT3(1), STAT5A(3) 9038289 14 13 14 2 5 1 2 1 5 0 0.155 0.690 1.000 81 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(3), GOT2(1), LDHC(1) 5029947 5 5 5 0 0 1 1 0 3 0 0.266 0.703 1.000 82 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 8 CCL11(1), CCR3(1), CD4(2), IL5RA(1), IL6(2) 3333018 7 7 7 3 1 2 1 0 3 0 0.731 0.708 1.000 83 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), CAD(7), CRAT(3), DARS(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), PC(3) 20201922 39 35 39 4 5 10 16 3 5 0 0.00361 0.714 1.000 84 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(2), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), TYR(4) 7538076 16 16 16 4 2 2 9 1 2 0 0.578 0.715 1.000 85 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(3), COPA(2), GBF1(4), GPLD1(3), KDELR3(1) 12398178 16 16 16 1 2 2 8 2 2 0 0.0526 0.717 1.000 86 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(3) 6165120 10 10 10 2 2 2 3 3 0 0 0.269 0.726 1.000 87 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(1) 4016454 4 4 4 0 2 0 1 0 1 0 0.308 0.727 1.000 88 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(1), CASP8(3), RIPK1(3), TNFRSF1A(1) 5615025 8 8 8 2 1 2 1 1 3 0 0.505 0.734 1.000 89 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 9 GRB2(1), KLK2(2), NTRK1(3), PLCG1(5), SHC1(1), SOS1(4) 8279817 16 15 16 3 3 4 4 2 3 0 0.224 0.735 1.000 90 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2) 8089692 24 23 22 5 2 5 9 6 2 0 0.265 0.740 1.000 91 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ6(2), NDUFA13(1) 3218436 4 4 4 0 0 1 2 1 0 0 0.363 0.740 1.000 92 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), ELK1(2), GRB2(1), JUN(1), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(5), RAF1(1), SHC1(1), SOS1(4) 11469861 23 21 23 4 5 5 4 3 6 0 0.112 0.744 1.000 93 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(2) 8162193 13 13 13 3 2 6 1 2 2 0 0.217 0.746 1.000 94 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), NAGLU(1) 15862509 29 26 29 4 5 5 8 9 2 0 0.0781 0.747 1.000 95 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TPI1(2) 13671255 21 21 21 3 5 8 7 0 1 0 0.0266 0.748 1.000 96 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(1) 1722279 3 3 3 2 1 0 0 2 0 0 0.893 0.752 1.000 97 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(5), ERBB3(9), NRG1(1) 7743918 17 17 17 4 2 2 7 5 1 0 0.483 0.753 1.000 98 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4), SELP(5) 12628863 18 17 18 2 1 2 7 5 3 0 0.128 0.756 1.000 99 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(6), GNAS(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2) 9502194 19 19 19 4 3 2 4 6 4 0 0.481 0.757 1.000 100 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 11 BAD(1), GHR(2), NFKB1(1), NFKBIA(1), PPP2CA(1), RELA(1) 7211061 7 7 7 1 1 4 1 0 1 0 0.250 0.758 1.000 101 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(1), PPARG(1) 4101630 4 4 4 1 0 1 3 0 0 0 0.700 0.766 1.000 102 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(1), PC(3), PDHA1(2) 7122336 10 10 10 2 2 3 2 1 2 0 0.259 0.769 1.000 103 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2) 7859514 11 11 11 2 3 1 1 5 1 0 0.268 0.773 1.000 104 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(3), IDH1(1), MDH2(2), SDHB(1), SUCLA2(1) 6888102 9 9 9 2 1 2 2 4 0 0 0.446 0.780 1.000 105 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(1), CD8A(1), ITGAL(1), ITGB2(3), PTPRC(1) 8056230 10 10 10 1 0 2 3 3 2 0 0.200 0.791 1.000 106 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(1) 10095384 11 11 11 1 0 2 5 2 2 0 0.255 0.792 1.000 107 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(3) 16372044 26 26 26 4 1 1 16 6 2 0 0.247 0.793 1.000 108 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(2), STAT1(1), STAT2(2), TYK2(4) 8247369 13 13 12 3 2 4 2 4 1 0 0.297 0.804 1.000 109 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NFKB1(1), NOX1(1), RELA(1), SOD1(1), XDH(3) 7397130 8 8 8 0 1 1 2 3 1 0 0.116 0.807 1.000 110 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), GPI(2), HK1(1), PGK1(2), PKLR(1), TPI1(2) 7071129 11 11 11 3 1 3 2 2 3 0 0.387 0.809 1.000 111 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(1) 6806982 11 10 11 3 1 3 1 3 3 0 0.396 0.813 1.000 112 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), PGD(2) 14330862 21 21 21 3 6 3 4 6 2 0 0.0931 0.818 1.000 113 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), MST1(3), MST1R(1) 4712565 6 5 6 0 2 1 2 0 1 0 0.185 0.821 1.000 114 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC1(1), APOBEC2(1), APOBEC3A(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 5596266 7 7 7 2 4 1 0 1 1 0 0.652 0.822 1.000 115 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(1), ITGAM(1), ITGB2(3), SELE(1), SELL(4) 8400483 10 10 10 1 0 0 4 3 3 0 0.247 0.826 1.000 116 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(1), DBH(4), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(1), SLC18A3(2) 10907598 17 17 17 3 4 4 5 2 2 0 0.191 0.829 1.000 117 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX5(1), DPEP1(3), GGT1(1), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 12007281 14 14 13 1 4 1 6 1 2 0 0.0628 0.833 1.000 118 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1) 1990989 1 1 1 0 0 0 1 0 0 0 0.815 0.837 1.000 119 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(4), ALDOB(2), GCK(2), GMDS(2), HK1(1), HK3(2), KHK(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), SORD(1), TPI1(2) 18792462 30 29 30 4 9 5 6 5 5 0 0.0133 0.848 1.000 120 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(2), EIF2S1(1), EIF2S2(1), NFKB1(1), NFKBIA(1), RELA(1) 7124364 7 7 7 0 2 2 2 0 1 0 0.121 0.852 1.000 121 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), PRDX1(1), PRDX5(1), TPO(6) 16810599 34 33 34 6 7 4 11 5 7 0 0.0777 0.857 1.000 122 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(1) 5850780 8 8 8 2 1 2 4 1 0 0 0.628 0.860 1.000 123 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(2), FARS2(1), GOT2(1), PAH(1) 6288828 6 6 6 0 0 1 4 1 0 0 0.210 0.870 1.000 124 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CD8A(1), CSF1(2), IL2(1), IL6(2) 4738422 8 8 8 3 0 2 3 1 2 0 0.654 0.871 1.000 125 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(12), ATR(2), BRCA1(8), BRCA2(11), CHEK2(2), FANCA(7), FANCC(1), FANCD2(3), FANCE(1), FANCF(1), FANCG(1), MRE11A(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(2) 33004179 57 53 57 7 7 9 11 9 21 0 0.0389 0.872 1.000 126 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(1), FARSB(3), GOT2(1), PAH(1) 6656910 7 7 7 1 1 1 5 0 0 0 0.369 0.872 1.000 127 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(1), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2) 10546107 27 23 27 6 5 7 9 1 5 0 0.182 0.873 1.000 128 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4) 9516390 12 12 12 2 0 0 5 5 2 0 0.416 0.880 1.000 129 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(2), ACP6(1), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), MTMR2(1), MTMR6(1), TYR(4) 11605737 19 19 19 4 2 4 9 2 2 0 0.394 0.883 1.000 130 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 18 BAD(1), CASP8(3), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(3), RAF1(1), RELA(1), RIPK1(3), TNFRSF1A(1) 12605541 19 19 18 4 3 6 2 4 4 0 0.163 0.886 1.000 131 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(3), F2(3), F2R(2), FGA(3), FGG(1), PLAT(2), PLAU(2), PLG(4), SERPINE1(2) 10355475 23 23 23 5 1 4 13 4 1 0 0.365 0.887 1.000 132 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 9 CAT(1), GHR(2), IGF1(1), IGF1R(2), SHC1(1), SOD1(1) 6342570 8 8 8 2 1 2 5 0 0 0 0.468 0.888 1.000 133 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(12), ATR(2), CDC25C(1), CHEK2(2) 11444004 17 16 17 3 3 3 2 4 5 0 0.352 0.889 1.000 134 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 19 CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), CDK7(2), E2F1(2), RBL1(1), TFDP1(1) 10203882 16 16 16 4 3 1 5 4 2 1 0.600 0.893 1.000 135 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PPT2(1) 6248775 10 10 10 3 0 3 4 2 1 0 0.651 0.893 1.000 136 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2) 8939931 11 11 11 2 3 1 1 5 1 0 0.258 0.897 1.000 137 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(5), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(4) 8997222 16 15 15 4 4 1 3 4 4 0 0.476 0.897 1.000 138 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT3(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5965869 7 7 7 2 0 3 1 1 2 0 0.614 0.904 1.000 139 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1B(2), BMPR2(2) 4678089 5 5 4 3 0 2 0 0 3 0 0.774 0.905 1.000 140 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(1), CD3G(1), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), JAK2(5), STAT4(5), TYK2(4) 11491155 28 24 27 7 1 5 5 9 8 0 0.407 0.906 1.000 141 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 17 CCND1(1), CCNE1(1), CDK2(1), CDK6(1), E2F1(2), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), RAF1(1), RELA(1), TFDP1(1) 10264722 15 15 15 3 5 3 3 2 2 0 0.227 0.907 1.000 142 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1) 4874805 10 9 9 4 4 1 4 0 1 0 0.609 0.908 1.000 143 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(3), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), ASS1(1), CAD(7), CRAT(3), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), NARS2(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1) 29281785 53 47 53 6 9 14 21 4 5 0 0.00142 0.913 1.000 144 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1) 2774811 1 1 1 1 1 0 0 0 0 0 0.860 0.916 1.000 145 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(1), ACO2(3), ACSS1(1), IDH1(1), MDH2(2), SUCLA2(1) 10182081 13 13 13 3 3 3 2 4 1 0 0.283 0.918 1.000 146 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 14 GNAS(5), GNB1(1), NFKB1(1), NOS3(2), NPPA(1), RELA(1) 9996012 11 11 11 2 2 3 2 2 2 0 0.346 0.919 1.000 147 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F2R(2), F5(11), F7(1), FGA(3), FGG(1), PROC(1), PROS1(1), SERPINC1(3), TFPI(1) 12507183 27 26 27 6 3 6 10 5 3 0 0.299 0.920 1.000 148 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), JUN(1), KEAP1(1), MAPK1(1), MAPK14(1), MAPK8(2) 6891651 7 7 7 2 2 1 1 0 2 1 0.555 0.925 1.000 149 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(2), RANGAP1(2) 6500247 5 5 5 0 0 1 2 0 2 0 0.496 0.932 1.000 150 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), NFS1(1), TPK1(1) 4912323 4 4 4 1 0 3 1 0 0 0 0.531 0.934 1.000 151 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(4), E2F1(2), MDM2(2), MYC(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2) 9909822 17 17 17 4 3 2 4 4 4 0 0.334 0.935 1.000 152 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), CASP8(3), DFFB(2), PRF1(2), SCAP(3), SREBF2(4) 13882674 15 14 15 2 1 8 2 1 3 0 0.0725 0.937 1.000 153 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(3), BDKRB2(1), KNG1(3), NOS3(2) 7725159 11 11 11 3 0 3 4 3 1 0 0.436 0.939 1.000 154 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 2524860 5 5 5 3 1 1 2 0 1 0 0.913 0.940 1.000 155 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMD1(5), PSMD11(1), PSMD2(1), PSMD6(2) 12322635 16 16 16 3 2 3 5 3 3 0 0.378 0.942 1.000 156 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(2), RDH12(1), RDH14(1) 3622515 4 4 4 2 0 1 0 2 1 0 0.786 0.943 1.000 157 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(1), NFKBIA(1), RELA(1) 10032516 14 14 14 3 1 4 2 2 5 0 0.423 0.944 1.000 158 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2C(2) 6323811 9 9 9 3 1 2 2 1 3 0 0.617 0.950 1.000 159 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), CDO1(1), CTH(3), GOT2(1), LDHC(1) 9442368 8 7 8 1 0 2 2 0 4 0 0.390 0.951 1.000 160 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TNFSF13B(1), TRAF3(1), TRAF6(2) 11171238 9 9 9 1 1 3 1 1 3 0 0.177 0.951 1.000 161 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(1), SRPR(7) 5730114 10 8 10 3 1 3 2 3 1 0 0.593 0.952 1.000 162 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(3), CDK5(1), MAPT(1), PPP2CA(1) 7232862 8 8 8 2 2 2 2 1 1 0 0.567 0.955 1.000 163 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1) 3762954 2 2 2 4 0 0 0 0 2 0 1.000 0.956 1.000 164 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), AOC2(1), AOC3(2), CES1(2), ESD(1) 4369833 7 7 7 3 2 1 3 0 1 0 0.685 0.956 1.000 165 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), CD3G(1), IL2(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1) 8187543 12 11 12 3 1 4 3 3 1 0 0.391 0.956 1.000 166 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(1), OGDH(2), SDHA(1), SUCLA2(1) 7334769 8 7 8 2 1 2 4 1 0 0 0.464 0.958 1.000 167 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), JUN(1), MAPK14(1), THBS1(4) 5482698 7 6 7 3 0 0 1 4 2 0 0.912 0.959 1.000 168 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(2), IKBKB(3), JAK2(5), NFKB1(1), NFKBIA(1), RELA(1), TNFRSF1A(1), USH1C(1), WT1(1) 11374545 16 15 16 3 3 3 3 2 5 0 0.275 0.960 1.000 169 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3) 4635501 9 9 9 3 2 5 0 1 1 0 0.609 0.961 1.000 170 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPOR(2), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(5), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4) 16707678 34 32 34 7 8 6 6 3 11 0 0.108 0.963 1.000 171 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(2), IL6(2), LDLR(1), LPL(1) 3987048 7 7 7 5 0 3 2 0 2 0 0.938 0.965 1.000 172 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(2), ACP6(1), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1) 13847691 30 24 29 7 7 5 10 4 4 0 0.223 0.965 1.000 173 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), GLB1(1), HEXB(1), LCT(6), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1) 12360660 15 15 15 3 2 2 4 5 2 0 0.355 0.966 1.000 174 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(5), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 7183176 10 10 10 3 2 2 2 3 1 0 0.659 0.969 1.000 175 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(2), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), ITGAX(4), TLR2(1), TLR4(8), TLR7(5), TLR9(1) 14287767 32 29 31 8 6 8 3 7 8 0 0.235 0.970 1.000 176 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(1), CD4(2), ITGAL(1), ITGB2(3), PTPRC(1) 8599734 11 11 11 3 0 3 3 3 2 0 0.431 0.970 1.000 177 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1) 8276775 6 6 6 1 1 2 3 0 0 0 0.422 0.970 1.000 178 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(4), B3GNT1(1), FUT2(2), ST8SIA1(1) 4617756 8 8 7 4 1 2 1 2 2 0 0.660 0.971 1.000 179 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 6272604 10 10 10 4 2 3 1 3 1 0 0.569 0.973 1.000 180 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), AASDHPPT(2), AASS(3) 5308290 6 6 6 3 1 1 2 0 2 0 0.933 0.973 1.000 181 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(3), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), PC(3), PCK1(1), SDHA(1), SDHB(1), SUCLA2(1) 15959346 18 17 18 3 4 3 5 5 1 0 0.160 0.973 1.000 182 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 8765523 14 14 14 4 2 5 2 2 3 0 0.465 0.974 1.000 183 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(2), JAK2(5), PTPRU(5), REG1A(1), STAT1(1) 8791380 14 14 14 4 2 2 2 3 5 0 0.734 0.974 1.000 184 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 22 CASP2(3), IKBKB(3), JUN(1), LTA(1), MAP2K3(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFRSF1A(1) 15456909 20 19 20 3 3 5 7 1 4 0 0.0931 0.975 1.000 185 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(3) 3628599 5 5 5 3 1 1 2 0 1 0 0.934 0.975 1.000 186 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(2) 4551339 6 6 6 3 2 1 1 1 1 0 0.859 0.977 1.000 187 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(1), HLA-A(6), ITGAL(1), ITGB2(3), PRF1(2) 6501768 16 14 15 6 3 3 2 4 4 0 0.643 0.977 1.000 188 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(2), DFFB(2), GZMA(1), HMGB2(1), PRF1(2), SET(1) 8268156 10 9 10 3 1 2 2 2 3 0 0.669 0.977 1.000 189 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 3343158 5 5 5 4 1 1 2 0 1 0 0.970 0.977 1.000 190 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(4), ESR1(2), GREB1(2), MTA3(2) 8166756 10 10 10 3 0 5 3 1 1 0 0.360 0.978 1.000 191 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(5), GNB1(1), PRKACA(1), PRKAR1A(1) 4554381 11 11 11 4 3 2 1 4 1 0 0.775 0.980 1.000 192 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(3), CREB1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(2) 8786817 14 14 14 4 2 2 4 5 1 0 0.570 0.980 1.000 193 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH5A1(1), CAD(7), CPS1(5), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GLS(1), GMPS(1), GOT2(1), GPT2(2), GSS(1), PPAT(1), QARS(2) 25419459 36 33 36 4 3 7 13 10 3 0 0.0212 0.981 1.000 194 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CD3G(1), CXCR3(2), ETV5(1), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), JAK2(5), JUN(1), MAPK14(1), MAPK8(2), STAT4(5), TYK2(4) 14431755 30 27 29 8 2 4 5 9 10 0 0.486 0.981 1.000 195 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 DFFB(2), HMGB2(1), TOP2A(1) 8107437 4 4 4 0 0 2 1 1 0 0 0.321 0.982 1.000 196 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 3333525 1 1 1 1 1 0 0 0 0 0 0.928 0.982 1.000 197 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(2), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), ILVBL(2), PANK2(1), PANK4(3), UPB1(3), VNN1(3) 13100880 28 27 28 7 5 4 6 8 5 0 0.390 0.982 1.000 198 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 10151661 10 10 10 3 2 3 5 0 0 0 0.544 0.985 1.000 199 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(1) 3398421 2 2 2 2 0 0 0 1 1 0 0.931 0.985 1.000 200 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST3GAL4(1), ST8SIA1(1) 7505628 10 10 9 4 1 2 1 2 4 0 0.624 0.987 1.000 201 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), GRB2(1), PTPRA(1) 7097493 9 9 9 3 3 0 4 1 1 0 0.659 0.988 1.000 202 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CMAS(1), CTBS(1), CYB5R1(2), GFPT1(1), GFPT2(3), GNE(3), GNPNAT1(1), HEXB(1), HK1(1), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1) 22232457 26 25 26 3 3 5 6 9 3 0 0.0429 0.988 1.000 203 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(3), IGF1(1), IL1A(1), IL6(2), KITLG(2), TGFB3(1) 6551454 10 8 10 4 2 2 2 2 2 0 0.684 0.989 1.000 204 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(3), ACACB(8), FASN(3), MCAT(1), OLAH(1) 12471186 16 16 16 4 6 0 7 2 1 0 0.399 0.989 1.000 205 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4) 19960083 32 31 32 6 7 4 6 3 12 0 0.190 0.989 1.000 206 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(2), IKBKB(3), IL2(1), JUN(1), MAP3K5(2), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1) 13092261 15 14 15 3 2 3 6 1 3 0 0.353 0.990 1.000 207 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG3(2), PSEN1(1) 6965673 9 9 9 3 0 4 4 1 0 0 0.594 0.990 1.000 208 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(3), C6(4), C7(5), IL1A(1), IL6(2), ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELP(5), SELPLG(1), VCAM1(2) 18880173 33 30 33 8 6 7 7 7 6 0 0.169 0.990 1.000 209 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST8SIA1(1) 7963956 11 11 10 5 1 1 3 2 4 0 0.783 0.991 1.000 210 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1) 14936220 28 27 28 7 11 4 3 6 4 0 0.184 0.991 1.000 211 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 11 CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(1), RELA(1), SP1(2) 8046090 11 11 11 4 3 3 2 2 1 0 0.605 0.993 1.000 212 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(3), JAK1(2), JAK2(5), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(1) 18178485 31 29 31 6 5 4 9 5 8 0 0.225 0.993 1.000 213 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1) 7216638 10 9 10 5 2 2 1 2 3 0 0.836 0.993 1.000 214 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(1), GNE(3), HEXB(1), HK1(1), HK3(2), PGM3(1), RENBP(1), UAP1(1) 13241319 14 14 14 3 3 1 3 5 2 0 0.402 0.994 1.000 215 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6444984 5 5 5 2 0 2 3 0 0 0 0.725 0.994 1.000 216 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(1), BLNK(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(4), RPS6KA1(1), RPS6KA3(2), SHC1(1), SOS1(4), SYK(2), VAV1(2), VAV2(1), VAV3(1) 22410921 37 35 37 7 10 8 12 5 2 0 0.0521 0.995 1.000 217 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(1), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PDGFRA(3), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3) 21165222 33 30 33 6 8 5 8 3 9 0 0.110 0.995 1.000 218 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(1) 4405830 1 1 1 1 1 0 0 0 0 0 0.935 0.995 1.000 219 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 10 BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PTK2(3), PTK2B(3) 9291282 13 13 12 4 2 5 4 2 0 0 0.409 0.995 1.000 220 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(2), PLCG1(5), PTK2B(3) 10322013 14 14 14 5 2 2 5 0 5 0 0.667 0.995 1.000 221 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(3), DHRS7(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2) 11206728 26 23 26 7 6 7 7 1 5 0 0.256 0.996 1.000 222 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT2(1), AKT3(3), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(3), SHC1(1), SOS1(4) 10070034 18 17 18 5 5 3 5 1 4 0 0.378 0.996 1.000 223 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT3(2), GALNT4(1), GALNT7(2), GALNT9(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 11218896 14 14 14 8 1 2 3 2 6 0 0.913 0.996 1.000 224 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(3), HMBS(1), PPOX(1) 5985642 5 5 5 2 2 0 3 0 0 0 0.854 0.996 1.000 225 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(2), GLS(1) 4389606 3 3 3 3 1 0 1 0 1 0 0.960 0.997 1.000 226 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(2), PLCB1(4), PTK2(3), RAF1(1), ROCK2(2) 19387680 28 27 28 5 5 9 5 6 3 0 0.141 0.997 1.000 227 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), JUN(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 9807915 12 12 12 4 4 0 5 2 1 0 0.667 0.997 1.000 228 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSA(1), ARSB(3), ARSE(2), ASAH1(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD2(2), SPTLC1(1), SPTLC2(2) 17037228 26 22 26 5 7 4 8 5 2 0 0.161 0.997 1.000 229 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), GRB2(1), IL3RA(1), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4) 13669734 24 24 24 6 6 3 4 3 8 0 0.258 0.998 1.000 230 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(1), ALDH5A1(1), CAD(7), CPS1(5), EARS2(3), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GFPT2(3), GLS(1), GLUD2(1), GMPS(1), GNPNAT1(1), GOT2(1), GPT2(2), GSS(1), NAGK(1), PPAT(1), QARS(2) 30338880 46 42 46 6 4 9 15 15 3 0 0.0147 0.998 1.000 231 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), NDUFA1(1), SDHA(1), SDHB(1), UQCRC1(2) 4929561 7 7 7 5 2 0 2 2 1 0 0.963 0.998 1.000 232 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), IL6R(1), JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), STAT3(1) 11702574 19 19 19 8 4 2 3 3 7 0 0.847 0.998 1.000 233 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), LMNB1(1), PRF1(2) 14685762 16 16 16 4 1 6 3 3 3 0 0.368 0.998 1.000 234 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(3), HMBS(1) 6471855 4 4 4 2 2 0 2 0 0 0 0.869 0.998 1.000 235 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4) 6669078 10 10 10 4 2 3 3 1 1 0 0.686 0.998 1.000 236 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1A1(1), MAN1B1(1), MGAT3(1), MGAT4B(1), MGAT5(2), RPN1(2) 14519973 14 14 14 3 2 3 4 2 3 0 0.370 0.998 1.000 237 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(4) 9504729 17 17 16 5 4 4 2 5 2 0 0.452 0.998 1.000 238 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), ASS1(1), CPS1(5), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1) 22414977 38 36 38 9 4 8 14 9 3 0 0.219 0.999 1.000 239 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(6), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 7646574 17 15 17 6 3 5 4 3 2 0 0.622 0.999 1.000 240 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(2), EP300(3), HDAC3(2), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(2) 16605771 19 19 18 4 2 6 4 2 5 0 0.201 0.999 1.000 241 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(3), ASAH1(1), CERK(1), CREB1(1), CREB3(1), DAG1(1), EPHB2(2), GNAQ(1), ITPKA(1), ITPKB(8), JUN(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4) 20853417 33 33 33 8 6 4 7 9 7 0 0.331 0.999 1.000 242 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(1), ECHS1(1), EHHADH(2), HADHB(1) 6467292 7 7 7 6 0 1 2 3 1 0 0.966 0.999 1.000 243 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(4), CREB1(1), EDN1(2), EP300(3), HIF1A(1), JUN(1), NOS3(2), P4HB(1) 13061334 17 16 16 5 1 4 3 3 6 0 0.672 0.999 1.000 244 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), SOAT1(1) 10616580 16 16 16 5 3 3 2 3 5 0 0.638 0.999 1.000 245 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(1), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), GATM(4), OTC(1) 13674297 21 21 21 5 2 4 8 6 1 0 0.370 0.999 1.000 246 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(1), EGF(2), EGFR(5), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3) 23033010 37 33 37 8 8 5 9 6 9 0 0.204 0.999 1.000 247 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(2), PSEN1(1) 7103577 5 5 5 2 0 2 1 2 0 0 0.714 0.999 1.000 248 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(3), C6(4), C7(5), C9(1) 9793719 16 16 16 5 3 5 3 2 3 0 0.484 0.999 1.000 249 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TKTL1(1), TKTL2(1), TPI1(2) 15269319 21 21 21 5 5 8 6 1 1 0 0.118 0.999 1.000 250 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 13 AKT2(1), AKT3(3), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PTK2B(3), RBL2(1), SHC1(1), SOS1(4) 12338352 20 19 20 5 4 6 5 1 4 0 0.308 0.999 1.000 251 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1) 11439948 13 12 13 4 3 5 1 1 3 0 0.419 0.999 1.000 252 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 35 AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), DAG1(1), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PLCG2(2), PPP1R13B(2), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2) 36121722 61 57 61 10 15 13 15 8 9 1 0.0140 0.999 1.000 253 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(4), ATM(12), ATR(2), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), E2F1(2), HDAC1(2), TFDP1(1), TGFB3(1) 20188740 29 27 29 6 5 4 6 5 9 0 0.292 0.999 1.000 254 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(1), CHST11(1), PAPSS1(2), SULT1A1(1), SULT1A2(1), SULT1E1(2), SUOX(3) 6452082 11 11 11 7 3 5 0 2 1 0 0.895 0.999 1.000 255 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 11 GLB1(1), HEXB(1), LCT(6), MANBA(1), NEU2(1) 11416626 10 10 10 3 1 1 3 3 2 0 0.695 1.000 1.000 256 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CAMKK1(3), CAMKK2(2), CREB1(1) 8972379 14 14 14 8 3 2 1 5 3 0 0.934 1.000 1.000 257 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 27 CD4(2), CSF1(2), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB3(1) 9390147 15 14 15 6 2 5 3 2 3 0 0.641 1.000 1.000 258 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CRY1(1), CSNK1E(2), PER1(3) 6447519 7 7 7 4 1 1 2 2 1 0 0.910 1.000 1.000 259 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKAR2A(1), PRKAR2B(1) 7605000 7 7 7 3 1 4 1 1 0 0 0.618 1.000 1.000 260 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(2), ARG2(1), ASL(3), ASS1(1), CKMT2(2), CPS1(5), DAO(1), EPRS(2), GATM(4), GLUD2(1), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), PARS2(1), PYCR2(1), PYCRL(3), RARS(2), RARS2(2) 27808950 40 39 39 8 7 7 17 7 2 0 0.119 1.000 1.000 261 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 24 ARHGDIB(1), BAG4(1), CASP2(3), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MADD(8), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), RIPK1(3), SPTAN1(2), TNFRSF1A(1) 25839255 40 37 40 8 4 13 10 6 7 0 0.111 1.000 1.000 262 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(3), ARHGEF1(5), F2(3), F2R(2), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PLCB1(4), PTK2B(3), ROCK1(1) 16637205 25 25 25 6 3 6 11 2 3 0 0.290 1.000 1.000 263 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(1), ATM(12), ATR(2), BAI1(7), BID(4), CASP8(3), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDK2(1), CDK6(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), PERP(2), RCHY1(1), RRM2(1), SERPINE1(2), SESN2(2), SIAH1(3), STEAP3(1), THBS1(4), TP53I3(1), TP73(1), TSC2(2) 48567558 82 69 82 12 15 11 14 19 22 1 0.0170 1.000 1.000 264 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(3), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(1), TRAF6(2) 12123891 13 12 13 4 1 5 4 1 2 0 0.523 1.000 1.000 265 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 15 CD86(2), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1) 9020037 10 10 10 6 0 1 4 3 2 0 0.953 1.000 1.000 266 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), GNAI1(1), GNB1(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(1), PTK2(3), RAF1(1), SYK(2), TBXAS1(1) 18573438 35 29 34 9 3 9 17 4 2 0 0.354 1.000 1.000 267 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(12), ATR(2), BRCA1(8), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CHEK2(2), EP300(3), MDM2(2), MYT1(2), PRKDC(8), RPS6KA1(1), WEE1(1) 32437860 48 45 47 9 8 8 11 8 13 0 0.0981 1.000 1.000 268 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(2), CTH(3), GGT1(1), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1) 9499152 12 12 12 7 4 3 2 0 3 0 0.800 1.000 1.000 269 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), WASF1(3), WASL(1) 6290856 9 9 9 7 1 2 5 0 1 0 0.988 1.000 1.000 270 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2), EP300(3), ESR1(2), MAPK1(1), MAPK3(1), PELP1(2) 11543883 11 11 10 5 1 4 2 0 4 0 0.767 1.000 1.000 271 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(1), ELK1(2), IKBKB(3), IRAK1(1), JUN(1), MAP2K3(1), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPARA(1), RELA(1), TIRAP(2), TLR10(1), TLR2(1), TLR3(1), TLR4(8), TLR7(5), TLR9(1), TRAF6(2) 25444302 38 34 37 9 8 8 7 5 10 0 0.183 1.000 1.000 272 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PLCG1(5), PTK2(3), PTK2B(3), PXN(1), RAF1(1), RELA(1) 18611970 23 22 23 5 2 8 6 4 3 0 0.179 1.000 1.000 273 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(12), BMPR1B(2), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), LHCGR(4), MLH1(1), MSH5(1), NRIP1(1), PGR(1), PRLR(1), ZP2(2) 21787311 35 31 35 9 3 9 6 7 10 0 0.339 1.000 1.000 274 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT3(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(5), ENPP6(1), PAFAH1B1(2), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PPAP2A(1), PPAP2C(2) 17659824 34 31 32 9 3 9 9 10 3 0 0.268 1.000 1.000 275 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(3), CPT1A(3), LEPR(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1) 11043981 15 15 15 7 6 1 4 1 3 0 0.903 1.000 1.000 276 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 14 CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(3), PLCG1(5), RPS6KA1(1), SHC1(1) 11560107 17 16 17 5 6 2 5 0 4 0 0.430 1.000 1.000 277 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(2), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2) 17964531 31 29 31 8 8 3 7 5 8 0 0.253 1.000 1.000 278 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 11 GRB2(1), ILK(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PTK2(3), SHC1(1), SOS1(4) 10141014 16 16 16 5 3 6 3 2 2 0 0.427 1.000 1.000 279 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(1), DLAT(1), DLD(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK4(2), PDP2(1), SDHA(1), SDHB(1), SUCLA2(1) 22026108 29 28 29 6 7 7 8 6 1 0 0.123 1.000 1.000 280 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 31 AKT2(1), AKT3(3), ARHGEF11(2), LPA(7), MAP3K5(2), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(1), PLD3(2), PTK2(3), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(3), SRF(1) 33991308 47 40 47 8 12 9 13 2 10 1 0.0392 1.000 1.000 281 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(1), ACO2(3), CLYBL(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), OGDHL(2), PC(3), PCK1(1), PCK2(1), SDHA(1), SDHB(1), SUCLA2(1) 23066979 29 27 29 6 6 5 8 8 2 0 0.127 1.000 1.000 282 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 19 ADCY1(3), BAD(1), CSF2RB(2), IGF1(1), IGF1R(2), IL3RA(1), KIT(5), KITLG(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 12989847 20 19 20 6 3 6 7 3 1 0 0.345 1.000 1.000 283 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1), TGFB3(1) 15566421 22 21 22 9 1 6 3 6 6 0 0.683 1.000 1.000 284 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1) 15897492 23 22 23 6 4 5 7 2 5 0 0.396 1.000 1.000 285 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1), MASP2(1), MBL2(1) 15956811 21 21 21 6 5 6 3 3 4 0 0.315 1.000 1.000 286 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1) 9978774 10 9 10 8 2 1 2 2 3 0 0.969 1.000 1.000 287 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ARPC1A(1), ARPC1B(1), ARPC2(2), PAK1(2), PDGFRA(3), WASL(1) 7426536 10 10 10 8 2 3 4 0 1 0 0.989 1.000 1.000 288 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF5(2) 8613930 7 7 7 3 1 2 3 0 1 0 0.876 1.000 1.000 289 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), GNAS(5), PLCE1(7), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAP2B(1) 10785918 19 19 19 6 4 3 3 6 3 0 0.654 1.000 1.000 290 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), OPLAH(4), TXNDC12(1) 17365257 25 24 24 6 7 4 6 6 2 0 0.231 1.000 1.000 291 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(4), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(4), FUT5(1), ST3GAL6(1), ST8SIA1(1) 11992071 21 21 20 7 4 5 3 6 3 0 0.378 1.000 1.000 292 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(2), PLCG1(5), PLCG2(2), SEC61A1(2), TRIM23(2) 28196298 42 40 42 9 8 6 15 5 8 0 0.147 1.000 1.000 293 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), FDXR(3) 12375363 11 11 10 4 3 1 4 1 2 0 0.725 1.000 1.000 294 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), HAL(2) 14374464 20 20 20 6 1 3 7 4 5 0 0.536 1.000 1.000 295 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(2), EP300(3), NCOA3(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RARA(1) 15839187 17 15 16 6 2 2 5 2 6 0 0.795 1.000 1.000 296 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(3), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(5), ITGB3(2), MAPK1(1), MAPK3(1), PDGFRA(3), PLCB1(4), PTK2(3), SMPD2(2) 17180709 27 25 27 8 6 8 6 4 3 0 0.391 1.000 1.000 297 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(2), PAX3(2), RARA(1), SIRT1(1), SP100(4), TNFRSF1A(1) 11864307 11 11 11 4 2 3 3 1 2 0 0.732 1.000 1.000 298 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(2), LSS(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1) 10188672 12 12 12 9 2 1 4 3 2 0 0.984 1.000 1.000 299 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(2), HADH(1), HSD17B10(1), HSD17B4(4), NTAN1(1), SIRT1(1), SIRT7(1), VNN2(3) 9111297 15 15 15 6 0 4 7 3 1 0 0.813 1.000 1.000 300 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(3), CREB1(1), CREB3(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(3), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(2), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TRAF3(1) 22739964 36 33 36 9 8 6 11 5 6 0 0.236 1.000 1.000 301 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(3), CRHR2(1), ELTD1(4), EMR1(2), EMR2(6), GHRHR(1), GIPR(1), GPR64(6), LPHN1(2), LPHN2(6), LPHN3(6), VIPR1(1) 21354333 48 45 48 12 5 5 21 7 9 1 0.273 1.000 1.000 302 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(2), HLA-A(6), ITGB1(2), KLRC1(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PTK2B(3), SYK(2), VAV1(2) 11566698 25 23 24 9 5 5 9 3 3 0 0.651 1.000 1.000 303 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1) 12920388 18 18 18 6 4 6 3 2 3 0 0.456 1.000 1.000 304 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABARAP(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GPHN(1), NSF(1), UBQLN1(1) 9217767 15 15 15 6 2 3 4 5 1 0 0.718 1.000 1.000 305 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CSF1(2), IL6R(1), SELL(4), SPN(2), TNFRSF1A(1), TNFRSF8(1) 10020348 13 13 12 5 1 2 7 1 2 0 0.714 1.000 1.000 306 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 38 APAF1(1), BAK1(1), BID(4), CASP2(3), CASP6(2), CASP8(3), FAS(1), FASLG(1), JUN(1), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(1), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF1(1) 24557052 32 29 32 8 7 9 6 2 8 0 0.215 1.000 1.000 307 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NQO2(1), PMVK(1), SQLE(1), VKORC1(1) 8503404 12 12 12 7 3 2 4 2 1 0 0.914 1.000 1.000 308 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), LIPA(1), RDH11(2), RDH12(1), RDH14(1), SLC27A5(2), SOAT1(1), SRD5A1(1), SRD5A2(3) 24276174 30 29 30 8 3 9 9 5 4 0 0.307 1.000 1.000 309 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 12345957 16 15 16 5 3 4 3 4 2 0 0.498 1.000 1.000 310 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(1), ARSB(3), ARSE(2), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B2(1), HSD3B2(3), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 20441226 33 29 33 9 5 6 14 6 2 0 0.341 1.000 1.000 311 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), EP300(3), LPL(1), NCOA1(1), NCOA2(1), PPARG(1) 14134146 9 9 8 5 0 2 3 0 4 0 0.891 1.000 1.000 312 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(1), ELK1(2), GRB2(1), INSR(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1) 16509948 23 22 23 7 4 5 6 3 5 0 0.512 1.000 1.000 313 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(3), IKBKB(3), LTA(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFAIP3(1), TRAF1(1), TRAF3(1) 15179073 17 16 17 5 1 6 7 0 3 0 0.395 1.000 1.000 314 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), ATG7(2), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), PIK3C3(2), PIK3R4(3), PRKAA1(1), PRKAA2(3), ULK1(2), ULK2(1) 16487640 27 26 27 8 2 8 9 4 4 0 0.565 1.000 1.000 315 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(5), HGS(3), TF(1), TFRC(1) 9799296 15 15 15 7 4 2 5 3 1 0 0.811 1.000 1.000 316 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(1), MBTPS2(2), SCAP(3), SREBF2(4) 9118902 12 12 12 8 0 4 6 1 1 0 0.918 1.000 1.000 317 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 GRB2(1), IL2RG(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), SHC1(1), STAT6(1) 10373220 10 10 10 5 2 1 2 3 2 0 0.895 1.000 1.000 318 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 49 ACTG1(1), APAF1(1), ARHGDIB(1), BAG4(1), BID(4), CASP2(3), CASP6(2), CASP8(3), DFFB(2), GSN(1), LMNB1(1), MAP2K7(1), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(3), PAK2(1), PRKDC(8), PSEN1(1), PSEN2(3), PTK2(3), RASA1(2), RELA(1), RIPK1(3), SPTAN1(2), TNFRSF1A(1), TRAF1(1) 49826946 58 53 58 8 10 16 13 8 11 0 0.00707 1.000 1.000 319 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTR(5) 13484679 19 18 19 8 4 2 6 3 4 0 0.736 1.000 1.000 320 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 12 BAD(1), GRB2(1), IGF1R(2), IRS1(1), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4) 10684518 14 14 14 6 2 6 2 2 2 0 0.666 1.000 1.000 321 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 24 ARHGDIB(1), CASP6(2), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), PTPN13(4), SPTAN1(2) 28687074 30 30 30 6 3 11 7 4 5 0 0.141 1.000 1.000 322 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1) 15421419 19 19 19 6 4 6 3 2 4 0 0.408 1.000 1.000 323 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), GLUD2(1), HAL(2) 16039959 21 21 21 7 1 3 7 5 5 0 0.608 1.000 1.000 324 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6) 12791103 15 15 15 6 1 2 6 3 3 0 0.796 1.000 1.000 325 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), NOS1(3), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 19841952 40 38 39 11 9 4 18 5 4 0 0.299 1.000 1.000 326 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(5), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 11333478 19 18 19 8 6 3 3 5 2 0 0.849 1.000 1.000 327 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(5), GNAQ(1), GNB1(1), MYLK(6), PLCB1(4), ROCK1(1) 15895464 21 21 21 6 3 4 7 3 4 0 0.434 1.000 1.000 328 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(2), EP300(3), IL2RG(1), IL7R(1), JAK1(2), JAK3(2), PTK2B(3), STAT5A(3), STAT5B(4) 18632250 21 20 20 7 4 2 5 3 7 0 0.519 1.000 1.000 329 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), SP1(2), SP3(3) 14982357 25 23 25 9 1 5 8 7 4 0 0.743 1.000 1.000 330 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(2), ELOVL5(3), ELOVL6(2), FADS2(4), FASN(3), SCD(1) 11350716 18 18 18 7 2 3 9 2 2 0 0.747 1.000 1.000 331 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), IMPDH1(2), POLB(1), POLG(1), PRPS2(1), RRM1(1) 9760764 8 8 8 4 1 1 5 0 1 0 0.871 1.000 1.000 332 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CRY1(1), CSNK1E(2), NPAS2(1), NR1D1(2), PER1(3), PER2(3), PER3(2) 12820002 15 15 15 7 4 1 3 4 3 0 0.849 1.000 1.000 333 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 18805644 22 21 22 6 5 5 6 4 2 0 0.380 1.000 1.000 334 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.889 1.000 1.000 335 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.889 1.000 1.000 336 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.889 1.000 1.000 337 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(2), EGFR(5), MAP2K1(1), MAPK14(1), NCOR2(3), RARA(1), THRA(1), THRB(1) 11415612 15 15 15 6 1 3 6 3 2 0 0.840 1.000 1.000 338 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), SRD5A1(1), SRD5A2(3) 17706468 24 22 24 8 2 7 10 3 2 0 0.590 1.000 1.000 339 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(7), PPP2CA(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1) 13840593 20 20 20 7 1 3 10 4 2 0 0.851 1.000 1.000 340 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 AKT2(1), AKT3(3), BAD(1), BTK(3), GRB2(1), GSK3A(1), IARS(6), INPP5D(3), PDK1(1), PPP1R13B(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TEC(1), YWHAB(1) 24239670 36 34 36 9 9 8 12 3 4 0 0.249 1.000 1.000 341 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(3), ELK1(2), FCER1A(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK2(1), PLA2G4A(7), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2) 26585559 56 50 55 13 8 15 18 8 7 0 0.116 1.000 1.000 342 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 8 CR1(8), CR2(2), ITGAL(1), ITGB2(3), PTPRC(1) 11004435 15 15 15 6 0 4 6 4 1 0 0.723 1.000 1.000 343 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1) 15401139 24 23 24 8 6 4 8 4 2 0 0.566 1.000 1.000 344 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NAGLU(1), NEU2(1) 25434162 36 33 36 9 5 5 10 13 3 0 0.375 1.000 1.000 345 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(2), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), PON1(1) 22431708 47 38 46 11 10 8 15 8 6 0 0.132 1.000 1.000 346 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(1), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 13449189 14 14 14 7 1 1 5 5 2 0 0.868 1.000 1.000 347 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 18 EIF4A2(5), EIF4G1(1), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(1), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(3), PDK2(1) 17080830 19 18 19 9 3 6 5 0 5 0 0.871 1.000 1.000 348 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), DRD2(1), GRM1(3), PLCB1(4), PPP2CA(1), PPP3CA(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 12191322 16 15 16 6 3 3 6 3 1 0 0.676 1.000 1.000 349 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 37323312 59 55 59 12 14 15 17 9 4 0 0.0188 1.000 1.000 350 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 37323312 59 55 59 12 14 15 17 9 4 0 0.0188 1.000 1.000 351 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(2), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(1), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGDS(1), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), S100A6(1), TBXAS1(1) 15539043 26 24 25 8 3 5 12 5 1 0 0.575 1.000 1.000 352 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), ESCO1(3), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), MYST3(2), MYST4(6), PNPLA3(1), TPO(6) 25729236 44 41 44 10 9 7 14 7 7 0 0.128 1.000 1.000 353 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(1), GPRC5A(1), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM8(1) 14653821 21 19 21 7 6 4 7 2 2 0 0.314 1.000 1.000 354 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 EGFR(5), IGF1R(2), MYC(1), POLR2A(2), PPP2CA(1), TEP1(9) 18647460 20 20 20 6 2 5 6 6 1 0 0.512 1.000 1.000 355 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(4), AP2M1(3), BIN1(1), DNM1(2), EPS15(2), PPP3CA(3), PPP3CB(3), SYNJ2(1) 17506203 21 21 21 9 2 2 8 4 5 0 0.861 1.000 1.000 356 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 15 EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), IGF1(1), IGF1R(2), INPPL1(1), PDK2(1), PPP2CA(1), RPS6(2) 10741809 12 12 12 8 2 4 5 0 1 0 0.909 1.000 1.000 357 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 IKBKB(3), IL1A(1), IL1R1(1), IRAK1(1), MAP3K7(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TLR4(8), TNFAIP3(1), TNFRSF1A(1), TRAF6(2) 15961881 25 22 24 8 4 6 7 4 4 0 0.544 1.000 1.000 358 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 18 BAD(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RELA(1), RHOA(2) 11442990 10 10 10 6 3 3 2 1 1 0 0.836 1.000 1.000 359 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 IFNA1(1), IFNB1(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(1), IRAK2(3), IRAK3(1), JUN(1), MAP2K3(1), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), TGFB3(1), TRAF6(2) 20685093 30 26 30 9 6 8 7 4 5 0 0.450 1.000 1.000 360 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 25 BAG4(1), CASP8(3), JUN(1), MAP3K7(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(1), RIPK1(3), TNFAIP3(1), TNFRSF1A(1) 19349148 18 16 18 9 2 5 4 1 5 1 0.913 1.000 1.000 361 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTAP(1), MTR(5) 16007511 21 20 21 9 4 4 6 3 4 0 0.737 1.000 1.000 362 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(4), ITGB1(2), L1CAM(2), LYN(4), SELP(5) 12020970 23 23 23 9 6 6 8 3 0 0 0.645 1.000 1.000 363 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(3), CREBBP(2), EP300(3), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(2), TGFB3(1), TGFBR1(2), TGFBR2(3) 18379764 19 17 18 8 2 6 3 4 4 0 0.800 1.000 1.000 364 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), MRPS7(2), RPL13A(2), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPS10(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS5(3), RPS6(2), RPSA(1) 17267406 27 26 27 7 2 5 12 6 2 0 0.441 1.000 1.000 365 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 GLB1(1), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NEU2(1) 14313624 15 15 15 6 1 1 4 7 2 0 0.833 1.000 1.000 366 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), NCK1(1), NCKAP1(3), NTRK1(3), PIR(1), WASF1(3), WASF3(1), WASL(1) 11829324 18 18 18 7 3 3 8 3 1 0 0.810 1.000 1.000 367 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(4), BCHE(2), CES1(2), CYP3A4(3), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2) 17328246 19 19 19 7 4 2 6 5 2 0 0.656 1.000 1.000 368 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(1), GLI2(3), GLI3(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2) 11980410 21 18 21 9 5 5 8 2 1 0 0.668 1.000 1.000 369 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(2), EXTL3(3), GLCE(2), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), NDST3(1) 15655146 22 21 22 9 3 2 6 8 3 0 0.844 1.000 1.000 370 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(2), EP300(3), IKBKB(3), MAP2K3(1), MAP3K7(1), MAPK14(1), NFKB1(1), NFKBIA(1), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1) 22611693 20 18 19 7 2 5 6 1 6 0 0.564 1.000 1.000 371 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(1) 18373680 37 34 35 10 4 9 9 8 7 0 0.236 1.000 1.000 372 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(1), CCKBR(1), CCR2(4), CCR3(1), CCR5(1), CELSR1(4), CELSR2(3), CELSR3(4), CHRM2(2), CHRM3(1), CXCR3(2), DRD4(1), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(4), GHRHR(1), GPR116(2), GPR132(1), GPR133(2), GPR143(3), GPR17(1), GPR56(2), GPR77(1), GPR84(2), GRM1(3), GRPR(1), HRH4(1), LGR6(2), LPHN2(6), LPHN3(6), LTB4R2(1), OR8G2(1), P2RY11(1), P2RY13(2), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4) 50133174 92 79 92 21 18 22 21 20 11 0 0.00858 1.000 1.000 373 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 17 EIF4A2(5), EIF4B(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), PDK2(1), PPP2CA(1), RPS6(2), TSC1(3), TSC2(2) 17126967 19 18 19 6 3 6 5 2 3 0 0.552 1.000 1.000 374 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2E2(1), GTF2F2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(8), TAF1L(7), TAF4B(2), TAF5L(2), TAF6(1), TAF7(1), TBPL2(2) 27078870 28 27 27 7 5 6 7 6 4 0 0.339 1.000 1.000 375 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 24 AKT2(1), AKT3(3), GRB2(1), IARS(6), IL13RA1(1), IL2RG(1), IL4R(1), INPP5D(3), JAK1(2), JAK2(5), JAK3(2), NR0B2(2), PI3(1), PPP1R13B(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), STAT6(1), TYK2(4) 25664340 46 42 45 11 10 6 13 8 9 0 0.270 1.000 1.000 376 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PCK2(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1) 35460594 42 39 42 9 8 11 14 6 3 0 0.0822 1.000 1.000 377 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GOT2(1), GPI(2), HK1(1), HK3(2), LDHC(1), MDH2(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKM(4), PFKP(4), PGK1(2), PKLR(1), TPI1(2) 32638632 45 43 45 10 12 12 10 6 5 0 0.0382 1.000 1.000 378 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), HDAC3(2), NCOA1(1), NCOA2(1), NCOA3(6), NCOR2(3), POLR2A(2), RARA(1), TBP(1) 19566144 19 19 19 7 2 2 7 4 4 0 0.821 1.000 1.000 379 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(2), EGFR(5), GRB2(1), MET(5), PDGFRA(3), SH3KBP1(1) 14905800 18 16 18 8 4 3 4 4 3 0 0.878 1.000 1.000 380 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 19 ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1) 16427307 20 20 20 9 4 5 4 5 2 0 0.784 1.000 1.000 381 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 19 ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1) 16427307 20 20 20 9 4 5 4 5 2 0 0.784 1.000 1.000 382 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(1), BID(4), CASP6(2), CASP8(3), DFFB(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(2) 25418445 20 19 20 5 3 8 1 2 6 0 0.245 1.000 1.000 383 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IRF1(1), IRF3(2), IRF6(2), JUN(1), LTA(1), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TP73(1), TRAF1(1), TRAF3(1) 39548028 54 48 54 11 10 17 11 6 10 0 0.0433 1.000 1.000 384 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), GAA(2), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1) 25033632 43 39 43 12 12 5 8 13 5 0 0.227 1.000 1.000 385 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(2), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 20820969 17 16 17 9 2 2 7 4 2 0 0.925 1.000 1.000 386 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(8), ACTN3(1), CAPN1(3), ITGA1(4), ITGB1(2), ITGB3(2), PTK2(3), PXN(1), SPTAN1(2), TLN1(9) 22364784 36 36 36 10 9 5 9 8 5 0 0.480 1.000 1.000 387 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), DARS(1), EPRS(2), FARS2(1), GARS(1), IARS(6), LARS(1), LARS2(2), NARS(1), QARS(2), RARS(2), SARS(2), TARS(4), WARS2(1) 24255894 30 29 30 9 3 7 11 5 4 0 0.549 1.000 1.000 388 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1), TKTL1(1), TKTL2(1) 18335655 30 29 30 10 11 4 4 7 4 0 0.422 1.000 1.000 389 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(3), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2) 26541450 48 45 48 13 8 12 14 8 6 0 0.227 1.000 1.000 390 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), CRKL(1), ELK1(2), GAB1(1), GRB2(1), HGF(3), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MET(5), PAK1(2), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RASA1(2), SOS1(4), STAT3(1) 31483686 48 41 48 12 10 12 12 6 8 0 0.211 1.000 1.000 391 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), PIGW(2) 19066749 15 14 15 8 2 3 5 4 1 0 0.879 1.000 1.000 392 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(1), ITPKA(1), ITPKB(8), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CB(4), PIK3CG(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2) 32654349 56 53 56 14 11 10 16 9 10 0 0.213 1.000 1.000 393 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 67 B2M(2), CALR(1), CANX(1), CD4(2), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR2DS4(1), KIR3DL2(4), KIR3DL3(1), KLRC1(2), KLRC3(1), LTA(1), NFYB(1), NFYC(1), RFXANK(1), TAP1(2) 29183934 67 56 66 19 8 17 23 7 12 0 0.326 1.000 1.000 394 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), DDX20(2), E2F1(2), E2F4(2), ETS1(2), ETS2(4), ETV3(2), HDAC2(3), HDAC5(2), JUN(1), NCOR2(3), RBL1(1), RBL2(1), SIN3A(3), SIN3B(2) 21072441 32 31 32 10 5 9 5 7 6 0 0.612 1.000 1.000 395 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(1), BAD(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), CD40(1), CD40LG(1), DFFB(2), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NFKBIA(1), NGFR(1), NTRK1(3), PTPN13(4), RIPK1(3), SFRS2IP(2), TNFRSF1A(1), TRAF1(1), TRAF3(1), TRAF6(2) 32781606 39 37 39 10 4 17 7 4 7 0 0.116 1.000 1.000 396 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 29 AKT2(1), AKT3(3), BCR(1), BTK(3), CD19(2), GAB1(1), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), NR0B2(2), PDK1(1), PITX2(2), PLCG2(2), PPP1R13B(2), PREX1(8), PTPRC(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SAG(1), SYK(2), TEC(1), VAV1(2) 38936586 59 50 59 14 14 12 19 7 7 0 0.0840 1.000 1.000 397 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 34 ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GAB1(1), GCK(2), IL1R1(1), JUN(1), MAP2K5(2), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK8(2), MYEF2(2), NFATC3(3), NR2C2(1), PAPPA(4), SHC1(1), TRAF6(2), ZAK(1) 34014630 52 47 51 13 10 10 11 5 16 0 0.378 1.000 1.000 398 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX5(1), CBR1(1), CBR3(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP4F2(1), DHRS4(1), GGT1(1), GPX5(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 30137601 42 40 40 11 6 9 16 6 5 0 0.153 1.000 1.000 399 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AMDHD1(2), AOC2(1), AOC3(2), ASPA(2), CARM1(1), CNDP1(2), DDC(1), FTCD(1), HAL(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), PRPS2(1), WBSCR22(2) 30204525 50 42 50 15 7 11 20 4 8 0 0.297 1.000 1.000 400 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(3), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1) 28015299 35 31 35 10 6 12 11 3 3 0 0.284 1.000 1.000 401 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGK(2), AGPAT3(2), AGPAT6(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT1(1), DGAT2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), GK2(2), GLA(2), GLB1(1), GPAM(1), LCT(6), LIPA(1), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(1), PPAP2A(1), PPAP2C(2) 45173700 70 62 69 19 15 14 21 10 10 0 0.186 1.000 1.000 402 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 36 ATF2(2), CREB1(1), ELK1(2), GRB2(1), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK14(1), MAX(2), MEF2A(1), MEF2C(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(1), TGFB3(1), TGFBR1(2) 25571052 35 32 34 10 3 10 14 2 6 0 0.429 1.000 1.000 403 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), DBH(4), DCT(1), DDC(1), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(1), TPO(6), TYR(4) 24130665 44 42 44 15 9 6 18 6 5 0 0.581 1.000 1.000 404 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(3), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(1), MEF2C(2), PAK1(2), PTK2(3), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 23591217 38 32 38 12 6 8 13 6 5 0 0.451 1.000 1.000 405 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(2), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(1), PTPRR(2), RAF1(1), RPS6KA1(1), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(1) 25173057 42 41 42 12 10 12 9 8 3 0 0.261 1.000 1.000 406 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), B4GALT1(2), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1), RDH11(2), RDH12(1), RDH14(1) 29738085 49 46 49 15 12 6 8 17 6 0 0.305 1.000 1.000 407 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 34 ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(2), ENPP7(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD2(2), SMPD3(1), SPHK2(2), SPTLC1(1), SPTLC2(2) 25688169 34 32 34 11 7 6 11 7 3 0 0.466 1.000 1.000 408 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(1), AGPAT3(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CLC(1), CPT1B(2), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), ETNK1(3), GNPAT(2), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH1B1(2), PCYT1A(1), PCYT1B(3), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(5), PLCG2(2), PPAP2A(1), PPAP2C(2) 38331228 67 61 64 18 11 12 20 16 8 0 0.245 1.000 1.000 409 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENTPD7(3), EP400(2), ERCC3(2), FPGS(1), GCH1(1), IFIH1(1), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(4), RAD54L(2), SETX(8), SKIV2L2(1), SMARCA2(4), SMARCA5(2) 48342957 61 52 60 14 12 11 19 10 9 0 0.137 1.000 1.000 410 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 ASAH1(1), BRAF(3), CREB1(1), CREB3(1), CREBBP(2), CRKL(1), DAG1(1), EGR1(1), EGR2(1), EGR3(3), ELK1(2), GNAQ(1), JUN(1), MAP1B(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NTRK1(3), OPN1LW(1), PIK3C2G(2), PTPN11(1), RPS6KA3(2), SHC1(1), TERF2IP(2) 35388093 45 43 45 13 9 5 13 8 10 0 0.461 1.000 1.000 411 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), ALDOA(4), ALDOB(2), FUK(2), GMDS(2), HK1(1), HK3(2), KHK(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), RDH11(2), RDH12(1), RDH14(1), SORD(1), TPI1(2), TSTA3(1) 29216382 37 35 37 11 10 8 6 6 7 0 0.240 1.000 1.000 412 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 55 ALG2(2), BAK1(1), BFAR(1), BTK(3), CAD(7), CASP8(3), EGFR(5), EPHB2(2), IL1A(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MET(5), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(4), RIPK1(3), ROCK1(1), TUFM(2) 52558155 65 58 65 15 10 16 16 8 14 1 0.134 1.000 1.000 413 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 BRAF(3), CPEB1(2), EGFR(5), ERBB2(8), ERBB4(6), ETS1(2), ETS2(4), ETV6(2), ETV7(1), FMN2(7), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(2), NOTCH2(7), NOTCH3(3), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(1), SOS1(4), SOS2(2), SPIRE1(1) 35457552 72 64 70 21 8 19 20 18 7 0 0.274 1.000 1.000 414 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), G6PC2(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGAM4(1), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 44603832 60 55 60 16 15 14 16 11 4 0 0.0907 1.000 1.000 415 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(8), CARM1(1), CCND1(1), CREBBP(2), EP300(3), ERCC3(2), ESR1(2), GRIP1(1), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(3), NRIP1(1), PELP1(2), POLR2A(2), TBP(1) 36497916 44 41 43 12 3 12 11 4 14 0 0.358 1.000 1.000 416 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(3), CARS2(2), DARS(1), DARS2(1), EARS2(3), EPRS(2), FARS2(1), FARSA(1), FARSB(3), GARS(1), IARS(6), IARS2(2), LARS(1), LARS2(2), NARS(1), NARS2(2), PARS2(1), QARS(2), RARS(2), RARS2(2), SARS(2), SARS2(2), TARS(4), TARS2(5), WARS2(1) 39107952 57 53 57 14 11 12 22 7 5 0 0.227 1.000 1.000 417 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 60 ATM(12), CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDC25A(1), CDK2(1), CDK7(2), CREB3(1), CREB3L1(2), CREB3L3(3), E2F1(2), E2F3(1), E2F4(2), E2F5(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), MNAT1(1), MYC(1), MYT1(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLE(5), POLE2(1), RBL1(1), RPA1(1), TFDP1(1), TFDP2(2), TNXB(3), WEE1(1) 53502696 72 67 72 16 13 15 19 9 15 1 0.132 1.000 1.000 418 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT2(1), AKT3(3), ASAH1(1), BRAF(3), DAG1(1), DRD2(1), EGFR(5), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(4), PITX2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(2), STAT3(1), TERF2IP(2) 43946760 77 71 77 21 12 17 19 16 13 0 0.172 1.000 1.000 419 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), F12(1), F2(3), F2R(2), F5(11), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(3) 34709727 50 46 50 15 8 12 17 9 4 0 0.421 1.000 1.000 420 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT2(1), AKT3(3), ARHGAP5(3), BAD(1), BRAF(3), CAPN2(2), CAV1(1), CCND1(1), CCND3(3), COL11A1(2), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), FARP2(5), FIGF(2), FLNA(5), FLNB(8), FLNC(9), FLT1(2), FN1(3), GRB2(1), GRLF1(5), HGF(3), IGF1(1), IGF1R(2), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), JUN(1), KDR(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MET(5), MYL7(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARVA(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PIP5K1C(4), PPP1R12A(2), PRKCG(2), PTK2(3), PXN(1), RAF1(1), RAPGEF1(3), RELN(13), RHOA(2), ROCK1(1), ROCK2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TLN1(9), TLN2(5), TNC(5), TNN(5), TNR(2), TNXB(3), VAV1(2), VAV2(1), VAV3(1), VCL(3), VWF(8) 279614049 417 247 414 164 86 77 114 70 69 1 0.946 1.000 1.000 421 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY3(2), ADCY4(2), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), ATP2B4(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCKBR(1), CD38(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(1), EGFR(5), ERBB2(8), ERBB3(9), ERBB4(6), F2R(2), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(10), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), GRPR(1), HRH1(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), LHCGR(4), LTB4R2(1), MYLK(6), MYLK2(1), NOS1(3), NOS3(2), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(2), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(11), RYR2(24), RYR3(13), SLC25A4(1), SLC8A1(1), SLC8A3(1), SPHK2(2), TACR2(1), TNNC2(1), TRPC1(3), VDAC2(2) 211650192 373 232 370 167 104 53 109 72 34 1 0.976 1.000 1.000 422 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 241 ACVR1B(5), ACVR1C(1), AKT2(1), AKT3(3), ARRB1(1), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CACNA2D1(4), CACNA2D2(4), CACNA2D3(5), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CD14(1), CDC25B(3), CRKL(1), DUSP10(1), DUSP16(3), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(2), EGFR(5), ELK1(2), FAS(1), FASLG(1), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(5), FLNB(8), FLNC(9), GRB2(1), IKBKB(3), IL1A(1), IL1R1(1), IL1R2(4), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(1), MAP3K10(4), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(2), MKNK2(1), MOS(2), MYC(1), NF1(14), NFATC2(1), NFATC4(3), NFKB1(1), NFKB2(3), NLK(1), NR4A1(1), NTRK1(3), NTRK2(3), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PPM1B(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(4), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KA6(3), SOS1(4), SOS2(2), SRF(1), STK3(1), STK4(2), TAOK1(2), TAOK2(1), TAOK3(3), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TRAF6(2), ZAK(1) 221123994 359 219 354 125 82 57 99 60 59 2 0.583 1.000 1.000 423 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 196 ACTN2(8), ACTN3(1), ACTN4(4), APC(3), ARAF(1), ARHGEF1(5), ARHGEF12(2), ARHGEF4(3), ARHGEF6(1), ARHGEF7(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CRKL(1), CYFIP1(1), CYFIP2(5), DIAPH2(1), DIAPH3(1), EGF(2), EGFR(5), EZR(2), F2(3), F2R(2), FGD3(3), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FN1(3), GIT1(1), GRLF1(5), GSN(1), IQGAP1(1), IQGAP2(2), IQGAP3(4), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), LIMK1(3), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(2), MSN(1), MYH10(7), MYH14(8), MYH9(4), MYL7(1), MYLK(6), MYLK2(1), NCKAP1(3), NCKAP1L(4), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PPP1R12A(2), PTK2(3), PXN(1), RAF1(1), RDX(1), RHOA(2), ROCK1(1), ROCK2(2), SCIN(2), SOS1(4), SOS2(2), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(2), VAV2(1), VAV3(1), VCL(3), WAS(2), WASF1(3), WASL(1) 212042610 296 202 294 118 60 48 85 58 45 0 0.957 1.000 1.000 424 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), COL11A1(2), COL17A1(5), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), DSC2(4), DSC3(1), DSG1(2), DSG3(4), DSG4(2), FN1(3), GJA1(2), GJA10(1), GJA4(1), GJA5(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GJC1(1), INA(1), ITGA6(3), ITGB4(4), KRT1(4), KRT14(2), KRT15(1), KRT17(5), KRT18(1), KRT19(2), KRT2(2), KRT25(2), KRT28(3), KRT3(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(3), KRT39(1), KRT4(2), KRT6A(1), KRT6C(1), KRT71(1), KRT72(2), KRT73(1), KRT79(1), KRT81(2), KRT82(2), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), LMNB1(1), NES(3), RELN(13), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(3), VIM(1), VWF(8) 188549244 275 201 272 115 60 55 77 38 45 0 0.927 1.000 1.000 425 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(1), ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CALCR(1), CALCRL(2), CCKBR(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(2), GABRG3(2), GABRQ(3), GABRR1(1), GALR1(2), GALR2(1), GH2(2), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLRA2(1), GLRA3(1), GPR156(2), GPR35(1), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA2(1), GRIA3(6), GRIA4(3), GRID1(7), GRID2(3), GRIK1(5), GRIK2(8), GRIK3(4), GRIK4(1), GRIK5(3), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRIN3A(4), GRIN3B(2), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM6(1), GRM8(1), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HRH4(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LEPR(3), LHB(2), LHCGR(4), LTB4R2(1), MAS1(2), MC2R(1), MC3R(2), MC4R(1), MCHR2(1), NMUR1(1), NMUR2(2), NPBWR2(1), NPFFR2(3), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PPYR1(1), PRLR(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(1), TACR2(1), THRA(1), THRB(1), TSHR(4), TSPO(1), UTS2R(1), VIPR1(1) 165953775 313 199 311 110 81 42 107 54 28 1 0.270 1.000 1.000 426 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(9), ATP1B1(1), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1S(2), CACNB1(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNB1(2), KCNJ3(1), MIB1(4), NME7(3), PKIG(1), PLCB3(1), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SLC8A3(1), USP5(4), YWHAB(1) 148069857 256 179 256 115 74 35 73 46 27 1 0.940 1.000 1.000 427 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 CD36(1), COL11A1(2), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), DAG1(1), FN1(3), FNDC1(6), FNDC3A(1), GP6(1), HSPG2(9), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), RELN(13), SDC4(1), SPP1(2), SV2A(1), SV2B(1), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(3), VWF(8) 171055209 243 177 242 109 52 52 65 39 35 0 0.981 1.000 1.000 428 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(4), ABLIM1(1), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(7), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(6), EPHA6(2), EPHA7(3), EPHA8(1), EPHB1(4), EPHB2(2), EPHB3(2), EPHB4(2), EPHB6(2), FES(2), GNAI1(1), GNAI2(1), ITGB1(2), L1CAM(2), LIMK1(3), LIMK2(1), LRRC4C(1), MAPK1(1), MAPK3(1), MET(5), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NGEF(2), NRP1(5), NTNG1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(3), PLXNB1(1), PLXNB2(3), PLXNB3(1), PLXNC1(2), PPP3CA(3), PPP3CB(3), PTK2(3), RASA1(2), RGS3(3), RHOA(2), RND1(1), ROBO1(4), ROBO2(4), ROBO3(1), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3B(1), SEMA3C(2), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(2), SEMA4B(1), SEMA4D(1), SEMA4F(5), SEMA4G(3), SEMA5A(8), SEMA5B(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(1), SLIT2(3), SLIT3(2), SRGAP1(8), SRGAP3(1), UNC5B(1), UNC5C(5), UNC5D(9) 150378228 221 168 221 77 47 38 70 30 36 0 0.589 1.000 1.000 429 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT2(1), AKT3(3), AMOTL1(2), ASH1L(5), CASK(4), CGN(1), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(2), EPB41L3(3), EXOC3(2), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), IGSF5(3), INADL(5), LLGL1(1), LLGL2(5), MAGI1(3), MAGI2(7), MAGI3(4), MLLT4(9), MPDZ(6), MYH1(5), MYH10(7), MYH11(7), MYH13(4), MYH14(8), MYH15(5), MYH2(2), MYH3(1), MYH4(6), MYH6(7), MYH7(9), MYH7B(7), MYH8(5), MYH9(4), MYL7(1), PARD3(3), PARD6B(1), PPP2CA(1), PPP2CB(2), PPP2R3A(3), PPP2R4(3), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), RAB13(1), RHOA(2), SPTAN1(2), SYMPK(5), TJP1(4), TJP3(2), VAPA(1), YES1(2), ZAK(1) 147980118 234 163 233 91 49 34 78 32 40 1 0.966 1.000 1.000 430 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(1), ACTA2(1), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ARRB1(1), ARRB2(1), ATF2(2), ATF3(1), ATF4(1), ATF5(2), ATP2A2(1), ATP2A3(1), CALCA(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(3), ETS2(4), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), IGFBP3(1), IL6(2), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), MIB1(4), MYLK2(1), NFKB1(1), NOS1(3), NOS3(2), PDE4B(2), PDE4D(6), PKIG(1), PLCB3(1), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RLN1(1), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SP1(2), TNXB(3), USP5(4), YWHAB(1) 132315339 212 160 212 89 59 28 64 35 26 0 0.896 1.000 1.000 431 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(1), ACVR1B(5), ACVR2A(3), AMHR2(2), BMP2(3), BMPR1B(2), BMPR2(2), CCL11(1), CCL13(1), CCL21(1), CCL23(1), CCL7(1), CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD40(1), CD40LG(1), CNTFR(1), CSF1(2), CSF2RA(2), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL6(1), CXCR3(2), EDA(2), EDA2R(1), EDAR(1), EGF(2), EGFR(5), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT4(1), GDF5(1), GH2(2), GHR(2), HGF(3), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL15(1), IL17B(2), IL17RA(2), IL17RB(3), IL18R1(1), IL18RAP(3), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), INHBA(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(2), LEPR(3), LIF(3), LIFR(3), LTA(1), MET(5), NGFR(1), OSMR(4), PDGFB(1), PDGFRA(3), PDGFRB(2), PF4(1), PLEKHO2(1), PRLR(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(2), TNFRSF8(1), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(1), TPO(6), TSLP(1), XCR1(2) 134607993 221 159 219 70 37 46 66 34 38 0 0.196 1.000 1.000 432 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(8), ACTN3(1), ACTN4(4), DMD(14), MYBPC1(2), MYBPC2(3), MYBPC3(1), MYH3(1), MYH6(7), MYH7(9), MYH8(5), MYL1(1), MYOM1(3), NEB(19), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM3(2), TTN(102), VIM(1) 108532983 194 143 194 34 32 22 68 44 27 1 0.00411 1.000 1.000 433 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 123 ACACA(3), ACACB(8), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), CBL(1), CBLB(9), CBLC(3), CRKL(1), ELK1(2), EXOC7(2), FASN(3), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(3), INPP5D(3), INSR(2), IRS1(1), IRS4(4), LIPE(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MKNK2(1), PCK1(1), PCK2(1), PDE3A(7), PDE3B(1), PFKM(4), PFKP(4), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PKLR(1), PPARGC1A(2), PPP1R3A(7), PPP1R3B(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKAG2(1), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(1), PTPRF(5), PYGB(3), PYGL(1), PYGM(4), RAF1(1), RAPGEF1(3), RHEB(1), RPS6(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(1), SORBS1(4), SOS1(4), SOS2(2), TRIP10(4), TSC1(3), TSC2(2) 118284114 185 140 185 65 43 33 50 34 25 0 0.669 1.000 1.000 434 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT2(1), AKT3(3), CBL(1), CBLB(9), CBLC(3), CCND1(1), CCND3(3), CNTFR(1), CREBBP(2), CSF2RA(2), CSF2RB(2), CSF3R(2), EP300(3), EPOR(2), GH2(2), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL13RA2(3), IL15(1), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), IRF9(3), JAK1(2), JAK2(5), JAK3(2), LEPR(3), LIF(3), LIFR(3), MYC(1), OSMR(4), PIAS2(3), PIAS4(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PRLR(1), PTPN11(1), SOCS4(1), SOCS5(1), SOS1(4), SOS2(2), SPRED1(3), SPRED2(1), SPRY3(1), STAM(2), STAM2(1), STAT1(1), STAT2(2), STAT3(1), STAT4(5), STAT5A(3), STAT5B(4), STAT6(1), TPO(6), TSLP(1), TYK2(4) 107157492 180 137 178 46 28 36 48 31 36 1 0.0509 1.000 1.000 435 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 123 ALCAM(2), CADM1(1), CD2(2), CD22(2), CD226(2), CD274(1), CD276(1), CD34(1), CD4(2), CD40(1), CD40LG(1), CD86(2), CD8A(1), CD99(2), CDH15(2), CDH2(1), CDH4(3), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CNTN1(5), CNTN2(4), CNTNAP1(3), CNTNAP2(3), CTLA4(1), ESAM(2), F11R(1), GLG1(2), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICOS(1), ICOSLG(1), ITGA4(1), ITGA6(3), ITGA8(2), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(5), ITGB1(2), ITGB2(3), ITGB8(2), L1CAM(2), MADCAM1(1), MAG(1), MPZL1(1), NCAM1(4), NCAM2(2), NEO1(4), NFASC(6), NLGN1(1), NLGN2(2), NLGN3(4), NRCAM(2), NRXN1(4), NRXN2(5), NRXN3(7), PDCD1(1), PTPRC(1), PTPRF(5), PTPRM(3), PVRL1(1), PVRL2(2), PVRL3(3), SDC4(1), SELE(1), SELL(4), SELP(5), SELPLG(1), SIGLEC1(1), SPN(2), VCAM1(2), VCAN(10) 106939482 188 132 186 59 36 35 57 30 30 0 0.194 1.000 1.000 436 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), ATIC(3), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(2), ENTPD6(1), FHIT(1), GMPR2(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(3), NUDT5(1), PAICS(1), PAPSS1(2), PDE10A(1), PDE11A(3), PDE1A(2), PDE1C(1), PDE2A(3), PDE3B(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1), XDH(3) 125975304 172 131 171 64 35 25 59 29 24 0 0.802 1.000 1.000 437 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(3), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCND1(1), CCND3(3), CER1(1), CHD8(2), CREBBP(2), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTBP2(1), CUL1(1), DAAM1(1), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LRP6(2), MAP3K7(1), MAPK10(1), MAPK8(2), MYC(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NKD1(1), NKD2(2), NLK(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PORCN(1), PPP2CA(1), PPP2CB(2), PPP3CA(3), PPP3CB(3), PRICKLE1(2), PRICKLE2(2), PRKACA(1), PRKCG(2), PRKX(1), PSEN1(1), RHOA(2), ROCK1(1), ROCK2(2), RUVBL1(1), SFRP1(3), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(2), SMAD4(1), TBL1X(4), TCF7(3), TCF7L2(2), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1) 118640028 156 124 155 61 31 26 44 32 22 1 0.798 1.000 1.000 438 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CCRL1(1), CHML(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(2), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR17(1), GPR174(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(1), GPR83(3), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LHCGR(4), MAS1(2), MC3R(2), MC4R(1), NMUR1(1), NMUR2(2), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), OR1F1(1), OR1Q1(2), OR7A5(2), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(2), SSTR2(1), SSTR3(2) 88127754 148 121 148 54 40 16 38 35 19 0 0.428 1.000 1.000 439 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CDS1(2), CDS2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPP5D(3), INPPL1(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), OCRL(4), PI4KA(4), PI4KB(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3C3(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PRKCG(2), SYNJ2(1) 93835053 138 121 137 53 24 25 39 24 26 0 0.822 1.000 1.000 440 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), BRAF(3), C7orf16(1), CACNA1A(6), CRHR1(3), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), GRIA1(6), GRIA2(1), GRIA3(6), GRID2(3), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IGF1(1), IGF1R(2), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(3), NOS3(2), NPR1(2), NPR2(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CA(1), PPP2CB(2), PRKCG(2), PRKG1(1), PRKG2(6), RAF1(1), RYR1(11) 85206927 142 119 139 43 31 37 39 19 16 0 0.0869 1.000 1.000 441 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 92 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(6), CACNA1D(5), CACNA1F(8), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH2(1), GRB2(1), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), LHB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MMP14(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLD1(1), PRKACA(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(4), SOS2(2) 96841563 144 116 140 65 34 25 39 25 21 0 0.955 1.000 1.000 442 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), ACVR1B(5), ACVR1C(1), BAIAP2(2), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), EGFR(5), EP300(3), ERBB2(8), FARP2(5), IGF1R(2), INSR(2), IQGAP1(1), LMO7(1), MAP3K7(1), MAPK1(1), MAPK3(1), MET(5), MLLT4(9), NLK(1), PARD3(3), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(1), PVRL2(2), PVRL3(3), RHOA(2), SMAD2(3), SMAD3(2), SMAD4(1), SNAI1(2), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(2), TGFBR1(2), TGFBR2(3), TJP1(4), VCL(3), WAS(2), WASF1(3), WASF3(1), WASL(1), YES1(2) 90863526 149 114 146 53 31 22 47 13 36 0 0.850 1.000 1.000 443 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), DRD2(1), EGF(2), EGFR(5), GJA1(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(8), ITPR2(3), ITPR3(4), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(2), NPR2(2), PDGFB(1), PDGFRA(3), PDGFRB(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKG1(1), PRKG2(6), PRKX(1), RAF1(1), SOS1(4), SOS2(2), TJP1(4), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1) 100605531 146 114 145 56 33 28 43 22 20 0 0.726 1.000 1.000 444 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), ATIC(3), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(2), NPR2(2), NT5E(3), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(4), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1) 97752642 142 112 141 53 25 21 51 22 23 0 0.854 1.000 1.000 445 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2A(1), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(2), ERCC3(2), G6PC2(2), GAA(2), GANC(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), IFIH1(1), MGAM(9), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(4), RAD54L(2), SETX(8), SI(6), SKIV2L2(1), SMARCA2(4), SMARCA5(2), TREH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), UXS1(2) 96218460 128 111 128 32 22 19 37 30 20 0 0.118 1.000 1.000 446 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 79 ABL1(4), ABL2(2), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), BTC(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CBL(1), CBLB(9), CBLC(3), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), ERBB3(9), ERBB4(6), GAB1(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRG1(1), NRG3(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), RAF1(1), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), STAT5A(3), STAT5B(4), TGFA(1) 73139820 135 110 133 41 21 25 39 30 20 0 0.411 1.000 1.000 447 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), AKAP1(2), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(6), AKAP6(6), AKAP8(1), AKAP9(9), ARHGEF1(5), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), ITPR1(8), KCNJ3(1), PALM2(1), PDE1A(2), PDE1B(2), PDE1C(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE8A(1), PLCB3(1), PPP3CA(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKD3(2), RHOA(2), USP5(4) 89469783 127 109 127 49 27 19 45 23 13 0 0.800 1.000 1.000 448 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN2(8), ACTN3(1), ACTN4(4), ARHGAP5(3), CD99(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), CYBB(1), ESAM(2), EZR(2), F11R(1), GNAI1(1), GNAI2(1), GRLF1(5), ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), ITK(4), MAPK14(1), MLLT4(9), MMP9(1), MSN(1), MYL7(1), NCF1(1), NCF2(2), NOX1(1), NOX3(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(2), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2), VCL(3) 92661855 125 109 125 53 22 18 38 19 28 0 0.963 1.000 1.000 449 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(1), ACVR1B(5), BMPR2(2), BUB1(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(1), CLK1(1), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(1), ITPKA(1), ITPKB(8), MAP3K10(4), MOS(2), NEK1(1), NEK3(2), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CB(4), PIK3CG(2), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), TGFBR1(2) 85517718 125 109 123 42 26 15 39 22 23 0 0.621 1.000 1.000 450 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(4), ABCA10(3), ABCA12(5), ABCA13(14), ABCA3(4), ABCA4(6), ABCA5(4), ABCA6(3), ABCA7(5), ABCA8(5), ABCA9(4), ABCB1(3), ABCB10(2), ABCB11(6), ABCB4(1), ABCB5(2), ABCB6(1), ABCB7(2), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(2), ABCC12(5), ABCC2(4), ABCC3(1), ABCC4(4), ABCC5(2), ABCC6(2), ABCC8(6), ABCC9(5), ABCD1(2), ABCD2(2), ABCD3(2), ABCG1(2), ABCG5(2), CFTR(6), TAP1(2) 90399621 132 108 132 39 24 18 54 21 15 0 0.227 1.000 1.000 451 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(4), AKT2(1), AKT3(3), ARHGEF6(1), ARHGEF7(2), BRAF(3), CAV1(1), CSE1L(2), EPHB2(2), GRB2(1), GRB7(3), GRLF1(5), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGB3BP(1), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MYLK(6), MYLK2(1), P4HB(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CB(4), PKLR(1), PLCG1(5), PLCG2(2), PTK2(3), RAF1(1), RHO(2), ROCK1(1), ROCK2(2), SHC1(1), SOS1(4), SOS2(2), TERF2IP(2), TLN1(9), TLN2(5), WAS(2) 89808966 133 107 133 48 27 24 31 24 27 0 0.666 1.000 1.000 452 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(1), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(1), GRB2(1), HLA-A(6), HLA-C(3), HLA-E(2), HLA-G(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), ITGAL(1), ITGB2(3), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL2(4), KLRC1(2), KLRC3(1), KLRK1(2), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(1), NCR2(2), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK1(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(1) 82051359 131 105 130 54 17 33 42 20 19 0 0.882 1.000 1.000 453 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(4), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREBBP(2), DCT(1), DVL1(2), DVL3(1), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), KIT(5), KITLG(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7(3), TCF7L2(2), TYR(4), TYRP1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1) 81138252 126 105 125 58 33 23 39 19 12 0 0.948 1.000 1.000 454 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT3(3), CAPN1(3), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(1), CAPN6(2), CAV1(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK4(4), MAPK6(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PTK2(3), PXN(1), RAPGEF1(3), RHO(2), ROCK1(1), ROCK2(2), SDCCAG8(5), SHC1(1), SHC3(1), SORBS1(4), SOS1(4), TLN1(9), TNS1(4), VAV2(1), VAV3(1), VCL(3) 103766676 133 105 133 53 25 26 31 26 25 0 0.846 1.000 1.000 455 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(4), ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), ATM(12), ATR(2), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC27(1), CDC7(1), CDK2(1), CDK6(1), CDK7(2), CHEK2(2), CREBBP(2), CUL1(1), E2F1(2), E2F3(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTTG2(1), RBL1(1), RBL2(1), SMAD2(3), SMAD3(2), SMAD4(1), SMC1A(4), SMC1B(2), TFDP1(1), TGFB3(1), WEE1(1), YWHAB(1) 102550890 124 102 123 28 20 19 33 24 27 1 0.132 1.000 1.000 456 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(3), BDKRB1(2), BDKRB2(1), C1QB(1), C2(1), C3(3), C3AR1(1), C4BPA(1), C4BPB(2), C5(3), C6(4), C7(5), C9(1), CD46(1), CD55(2), CFB(1), CFH(8), CPB2(1), CR1(8), CR2(2), F12(1), F13A1(3), F2(3), F2R(2), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), KNG1(3), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(2), PLG(4), PROC(1), PROS1(1), SERPINA1(4), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(2), TFPI(1), VWF(8) 68212794 117 102 116 34 13 24 41 22 17 0 0.302 1.000 1.000 457 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(3), ADCY8(4), ARAF(1), ATF4(1), BRAF(3), CACNA1C(6), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREBBP(2), EP300(3), GNAQ(1), GRIA1(6), GRIA2(1), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), ITPR1(8), ITPR2(3), ITPR3(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP1R12A(2), PPP1R1A(2), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3) 78336063 125 99 123 48 29 26 35 18 17 0 0.622 1.000 1.000 458 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(5), ASH2L(3), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT1(3), EZH1(1), EZH2(1), FBXO11(1), HCFC1(7), KDM6A(4), MEN1(2), MLL(6), MLL2(8), MLL4(5), MLL5(4), OGT(2), PAXIP1(3), PRDM2(2), PRDM6(1), PRDM7(1), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), RBBP5(1), SATB1(2), SETD1B(1), SETD2(5), SETD7(1), SETD8(1), SETDB1(7), SETMAR(2), SMYD3(4), SUV420H1(2), SUZ12(3), WHSC1(7), WHSC1L1(1) 86983455 113 98 112 26 16 18 34 18 27 0 0.152 1.000 1.000 459 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT2(1), AKT3(3), CARD11(3), CBL(1), CBLB(9), CBLC(3), CD3E(1), CD3G(1), CD4(2), CD40LG(1), CD8A(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IKBKB(3), IL2(1), ITK(4), JUN(1), LAT(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPRC(1), RHOA(2), SOS1(4), SOS2(2), TEC(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(1) 72575529 108 95 108 41 14 25 36 21 11 1 0.793 1.000 1.000 460 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(1), ACVR1B(5), ACVR1C(1), ACVR2A(3), AMHR2(2), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(2), BMPR2(2), CHRD(3), COMP(3), CREBBP(2), CUL1(1), E2F4(2), E2F5(1), EP300(3), FST(1), GDF5(1), GDF6(2), ID2(1), INHBA(1), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), RBL1(1), RBL2(1), RHOA(2), ROCK1(1), ROCK2(2), RPS6KB2(4), SMAD2(3), SMAD3(2), SMAD4(1), SMAD9(2), SMURF2(1), SP1(2), TFDP1(1), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(2), THBS4(1), ZFYVE16(3), ZFYVE9(3) 73937838 107 94 105 33 21 15 25 19 27 0 0.516 1.000 1.000 461 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(4), CD14(1), CD19(2), CD1A(1), CD1B(3), CD1C(2), CD1D(3), CD1E(3), CD2(2), CD22(2), CD33(1), CD34(1), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(1), CD4(2), CD5(2), CD55(2), CD8A(1), CD9(2), CR1(8), CR2(2), CSF1(2), CSF2RA(2), CSF3R(2), DNTT(3), EPOR(2), FCGR1A(1), FLT3(3), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1R1(1), IL1R2(4), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7R(1), ITGA1(4), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(5), KITLG(2), TFRC(1), TPO(6) 61973652 112 93 112 31 21 23 32 18 18 0 0.0960 1.000 1.000 462 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST2(3), CHST3(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL3(3), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GANAB(1), GCNT4(1), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), NDST3(1), OGT(2), RPN1(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(3), UST(2), WBSCR17(4), XYLT1(1), XYLT2(1) 81492645 111 91 111 52 18 21 29 21 22 0 0.975 1.000 1.000 463 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(4), ATM(12), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND3(3), CCNE1(1), CDAN1(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC7(1), CDK2(1), CHEK2(2), DTX4(1), E2F1(2), E2F3(1), E2F4(2), E2F5(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), HDAC8(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTPRA(1), PTTG2(1), RBL1(1), SMAD4(1), TBC1D8(1), TFDP1(1), WEE1(1) 82136028 107 89 106 28 15 19 26 21 25 1 0.276 1.000 1.000 464 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 95 AKT2(1), AKT3(3), CASP8(3), CD14(1), CD40(1), CD86(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(3), IKBKE(1), IL12A(1), IL12B(1), IL6(2), IRAK1(1), IRAK4(2), IRF3(2), JUN(1), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR3(1), TLR4(8), TLR5(1), TLR7(5), TLR8(3), TLR9(1), TRAF3(1), TRAF6(2) 63668046 100 86 99 35 14 23 20 18 24 1 0.550 1.000 1.000 465 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(2), BRAF(3), CREB1(1), ELK1(2), GRB2(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP3K9(3), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK8(2), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(2), MKNK2(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KB2(4), SHC1(1), SP1(2), STAT1(1), TGFB3(1), TGFBR1(2) 71977269 95 84 94 27 19 17 27 9 23 0 0.398 1.000 1.000 466 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CD2BP2(1), CLK3(1), CLK4(1), COL2A1(4), CPSF1(3), CPSF3(1), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(3), DDX20(2), DHX15(2), DHX38(2), DHX8(1), DICER1(2), FUS(1), GIPC1(1), LOC440563(2), NCBP1(1), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(1), POLR2A(2), PRPF3(2), PRPF4(2), PRPF4B(3), PRPF8(6), PSKH1(2), PTBP1(2), RBM17(1), RBM5(2), RNGTT(1), SF3B2(2), SF3B4(2), SF4(4), SFRS14(1), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(5), TXNL4A(1), XRN2(3) 77591787 98 84 98 22 16 22 29 15 15 1 0.127 1.000 1.000 467 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPPL1(1), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(1), OCRL(4), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CB(4), PIK3CG(2), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), SYNJ2(1) 54687555 88 83 88 29 15 12 29 14 18 0 0.624 1.000 1.000 468 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(2), BAD(1), CABIN1(5), CD3E(1), CD3G(1), CD69(2), CNR1(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR2(1), EGR3(3), EP300(3), FCER1A(2), GRLF1(5), GSK3A(1), ICOS(1), IFNA1(1), IFNB1(1), IL2(1), IL6(2), ITK(4), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK8(2), MEF2A(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), P2RX7(1), PAK1(2), PPP3CB(3), PTPRC(1), RELA(1), RPL13A(2), SP1(2), SP3(3), TRPV6(2), VAV1(2), VAV2(1), VAV3(1), XPO5(2) 68546400 94 81 93 42 12 19 25 13 24 1 0.973 1.000 1.000 469 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 67 ACACB(8), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), AKT2(1), AKT3(3), CAMKK1(3), CAMKK2(2), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), G6PC2(2), IKBKB(3), IRS1(1), IRS4(4), JAK1(2), JAK2(5), JAK3(2), LEPR(3), MAPK10(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(1), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(3), PTPN11(1), RELA(1), SLC2A4(1), STAT3(1), TNFRSF1A(1), TYK2(4) 60879546 91 79 90 27 19 12 25 18 16 1 0.401 1.000 1.000 470 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), CARM1(1), DBH(4), DCT(1), DDC(1), ECH1(1), ESCO1(3), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(2), MYST4(6), PNPLA3(1), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPO(6), TYR(4), TYRP1(2), WBSCR22(2) 44866458 81 71 81 25 16 15 29 9 12 0 0.421 1.000 1.000 471 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT3(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CHPT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(2), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(2), MYST4(6), PCYT1A(1), PCYT1B(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PNPLA3(1), PPAP2A(1), PPAP2C(2), PTDSS1(1), PTDSS2(1) 50287302 80 71 77 26 14 16 21 20 9 0 0.414 1.000 1.000 472 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AKT2(1), AKT3(3), APAF1(1), ATM(12), BAD(1), BID(4), CAPN1(3), CAPN2(2), CASP6(2), CASP8(3), CSF2RB(2), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(3), IRAK3(1), IRAK4(2), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(3), PIK3CB(4), PIK3CG(2), PIK3R3(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1) 60195096 84 71 84 20 11 23 17 16 16 1 0.0858 1.000 1.000 473 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 69 AKT2(1), AKT3(3), BTK(3), FCER1A(2), GAB2(2), GRB2(1), INPP5D(3), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), PDK1(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PRKCE(1), RAF1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1) 50540802 76 69 74 25 14 18 23 12 9 0 0.400 1.000 1.000 474 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), ENTPD4(2), ENTPD6(1), NME6(1), NME7(3), NT5C1B(4), NT5C3(1), NT5E(3), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2), UPRT(1) 62948106 75 66 75 31 12 11 24 16 12 0 0.849 1.000 1.000 475 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT2(1), AKT3(3), BAD(1), KDR(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAF1(1), SH2D2A(2), SHC2(1), SPHK2(2) 51099516 75 66 73 36 10 19 23 15 8 0 0.933 1.000 1.000 476 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CX3CR1(2), CXCR3(2), EDNRA(1), EDNRB(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR77(1), GRPR(1), LHCGR(4), MC2R(1), MC3R(2), MC4R(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR2(1), TSHR(4) 38606529 73 66 73 26 15 10 20 19 9 0 0.374 1.000 1.000 477 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 58 AKT2(1), AKT3(3), BAD(1), CDK2(1), CREB1(1), CREB3(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(4), MET(5), MYC(1), NOLC1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PPP1R13B(2), PREX1(8), PTK2(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(2), TSC1(3), TSC2(2), YWHAB(1) 53808924 77 65 77 24 14 17 27 9 10 0 0.457 1.000 1.000 478 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(1), DHH(1), GLI1(2), GLI2(3), GLI3(4), LRP2(18), PRKACA(1), PRKX(1), PTCH1(6), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1) 44272254 74 64 74 26 26 9 16 16 7 0 0.481 1.000 1.000 479 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 42 AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(2), DAG1(1), GRB2(1), GSK3A(1), INPP5D(3), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(1), NR0B2(2), PDK1(1), PLCG2(2), PPP1R13B(2), PPP3CA(3), PPP3CB(3), PTPRC(1), RAF1(1), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2) 51812358 74 64 74 24 12 22 22 10 8 0 0.269 1.000 1.000 480 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2A(1), ENPP1(4), ENPP3(2), GAA(2), GANAB(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), MGAM(9), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(6), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2), UXS1(2) 44375175 70 64 70 21 12 9 20 17 12 0 0.448 1.000 1.000 481 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT2(1), AKT3(3), BLNK(1), BTK(3), CARD11(3), CD19(2), CD22(2), CD79A(1), CD79B(1), CR2(2), IFITM1(1), IKBKB(3), INPP5D(3), JUN(1), LYN(4), MALT1(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PLCG2(2), PPP3CA(3), PPP3CB(3), SYK(2), VAV1(2), VAV2(1), VAV3(1) 52844103 70 63 70 30 9 16 25 10 9 1 0.885 1.000 1.000 482 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(4), CACNA1A(6), CACNA1B(7), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(4), KCNB1(2), PDE1A(2), PLCB2(2), PRKACA(1), PRKX(1), SCNN1B(1), TAS1R1(1), TAS1R2(2), TAS1R3(1), TAS2R1(1), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R40(1), TAS2R43(3), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 44161728 68 63 68 34 17 13 13 15 10 0 0.936 1.000 1.000 483 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), EGFR(5), F11R(1), GIT1(1), IGSF5(3), IKBKB(3), JUN(1), LYN(4), MAPK10(1), MAPK14(1), MAPK8(2), MET(5), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(5), PLCG2(2), PTPN11(1), PTPRZ1(5), RELA(1), TCIRG1(1), TJP1(4) 53977755 69 62 69 20 8 13 25 6 16 1 0.488 1.000 1.000 484 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(3), AXIN1(1), CCND1(1), CCND3(3), CSNK1E(2), DVL1(2), DVL3(1), FBXW2(2), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(2), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(1), TCF7(3), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT5B(2), WNT6(1), WNT7A(5) 44264142 64 59 64 25 15 11 16 16 5 1 0.646 1.000 1.000 485 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A2(1), CYP1B1(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHDH(1), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 44794971 68 58 68 23 9 15 28 9 7 0 0.439 1.000 1.000 486 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), APOA5(1), AQP7(3), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), CYP27A1(1), CYP8B1(1), EHHADH(2), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK2(2), HMGCS2(1), ILK(2), LPL(1), PCK1(1), PCK2(1), PLTP(1), PPARA(1), PPARG(1), SCD(1), SLC27A2(1), SLC27A4(4), SLC27A5(2), SORBS1(4), UCP1(1) 48001746 62 57 62 28 9 14 15 12 12 0 0.895 1.000 1.000 487 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 91 ANK2(4), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(3), RPL13A(2), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(1), RPL7(1), RPLP2(1), RPS10(1), RPS14(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS4X(1), RPS5(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), RPSA(1), SLC36A2(1), TBC1D10C(2) 39308724 62 57 62 15 10 8 28 11 5 0 0.322 1.000 1.000 488 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(2), CTBP2(1), DLL1(1), DLL4(1), DTX1(4), DTX2(2), DTX4(1), DVL1(2), DVL3(1), EP300(3), HDAC1(2), HDAC2(3), JAG1(1), JAG2(1), MAML1(1), MAML2(3), MAML3(2), NCOR2(3), NCSTN(2), NOTCH1(2), NOTCH2(7), NOTCH3(3), NUMB(1), NUMBL(4), PSEN1(1), PSEN2(3), PTCRA(1), RBPJL(4), SNW1(2) 50645244 64 56 63 26 13 14 17 8 12 0 0.708 1.000 1.000 489 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(8), LAT(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLCG1(5), PTPRC(1), RAF1(1), RASGRP2(2), RASGRP4(1), SOS1(4), SOS2(2), VAV1(2), ZAP70(1) 42438942 61 56 61 17 13 13 13 13 8 1 0.313 1.000 1.000 490 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CARM1(1), CAT(1), CYP1A2(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), INMT(2), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(2), MAOA(2), MAOB(1), METTL2B(2), OGDH(2), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPH2(1), WARS2(1), WBSCR22(2) 46074132 64 55 64 26 8 18 24 6 8 0 0.758 1.000 1.000 491 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 40 AKT2(1), AKT3(3), ARHGEF11(2), BTK(3), GDI1(4), INPPL1(1), ITPR1(8), ITPR2(3), ITPR3(4), LIMK1(3), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDK1(1), PIK3CG(2), PITX2(2), PPP1R13B(2), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), SAG(1), WASF1(3), WASL(1) 49717434 64 54 64 28 10 14 17 12 11 0 0.828 1.000 1.000 492 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 APC(3), AR(3), ASAH1(1), BRAF(3), CCL13(1), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PITX2(2), PTX3(1), RAF1(1) 37616358 55 54 55 21 7 11 13 14 10 0 0.709 1.000 1.000 493 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(1), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA9(1), NDUFB3(1), NDUFB4(1), NDUFB9(1), NDUFS2(2), NDUFS3(1), NDUFS7(1), NDUFV1(1), NDUFV2(1), PPA1(2), SDHA(1), SDHB(1), TCIRG1(1), UQCRC1(2), UQCRC2(1) 43449393 58 53 58 16 9 7 21 11 10 0 0.385 1.000 1.000 494 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 ACTA1(1), BDKRB2(1), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(2), PDE2A(3), PDE3A(7), PDE3B(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(6), RYR2(24) 31705245 58 53 58 32 8 10 26 10 4 0 0.982 1.000 1.000 495 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(1), ARSE(2), CARM1(1), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B1(1), HSD17B2(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), WBSCR22(2) 37863267 59 52 59 21 11 11 24 7 6 0 0.616 1.000 1.000 496 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PIPOX(2), RDH11(2), RDH12(1), RDH14(1), SARDH(2), SARS(2), SARS2(2), TARS(4), TARS2(5) 33053865 55 51 55 21 8 12 12 13 10 0 0.683 1.000 1.000 497 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), CAMK2A(1), CAMK2D(3), CAMK2G(1), CDK5(1), F2(3), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(1), MYLK(6), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3) 32132139 53 50 53 22 8 10 15 9 11 0 0.808 1.000 1.000 498 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(8), ACTN3(1), BCR(1), CAPN1(3), CAV1(1), CRKL(1), GRB2(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), SOS1(4), TLN1(9), VCL(3) 36335169 53 50 53 17 11 9 13 9 11 0 0.522 1.000 1.000 499 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(3), AR(3), ESR1(2), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1H2(3), NR1I3(1), NR2C2(1), NR2E1(2), NR4A1(1), NR4A2(1), NR5A2(4), PGR(1), PPARA(1), PPARG(1), RARA(1), RARB(4), RARG(3), ROR1(7), RORC(3), THRA(1), THRB(1) 30889989 52 50 52 20 10 12 10 6 14 0 0.683 1.000 1.000 500 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), NT5E(3), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2) 43647123 54 50 54 23 5 10 17 10 12 0 0.837 1.000 1.000 501 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CAT(1), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), WARS2(1) 41909634 60 50 60 25 7 14 20 12 7 0 0.789 1.000 1.000 502 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGPAT3(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DGAT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), GLA(2), GLB1(1), LCT(6), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(1), PPAP2C(2) 37096176 55 49 54 19 12 10 17 8 8 0 0.588 1.000 1.000 503 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1) 37995594 54 49 53 19 7 7 19 8 13 0 0.656 1.000 1.000 504 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1) 37995594 54 49 53 19 7 7 19 8 13 0 0.656 1.000 1.000 505 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PLCB2(2), PLCG1(5), PLCG2(2), SARDH(2), SARS(2), TARS(4) 32456619 53 48 53 20 8 10 13 11 11 0 0.714 1.000 1.000 506 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADSB(3), ACADVL(2), ACAT1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PECI(1) 37314693 50 48 50 18 7 14 17 8 4 0 0.559 1.000 1.000 507 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT2(1), AKT3(3), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CB(4), PIK3CG(2), PIK3R3(1), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), TSC1(3), TSC2(2), ULK1(2), ULK2(1) 37422177 51 48 51 18 8 13 14 10 6 0 0.646 1.000 1.000 508 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG1(1), ACTG2(2), FLNA(5), FLNC(9), FSCN3(1), GDI1(4), LIMK1(3), MYH2(2), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(3), WASL(1) 35439807 51 48 51 21 8 11 17 8 7 0 0.818 1.000 1.000 509 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), OGDH(2), OGDHL(2), PIPOX(2), PLOD1(1), PLOD2(1), PLOD3(2), RDH11(2), RDH12(1), RDH14(1), SETD7(1), SETDB1(7) 42221439 50 47 49 22 6 13 18 8 5 0 0.834 1.000 1.000 510 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(1), PI3(1), PIK3C2G(2), RIPK3(1), RPS4X(1), SGCB(1) 34445580 50 47 50 22 6 17 9 10 8 0 0.751 1.000 1.000 511 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 45 ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(2), EHHADH(2), EP300(3), FABP1(1), HSD17B4(4), JUN(1), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(1), NCOR2(3), NFKBIA(1), NR0B2(2), NRIP1(1), PPARA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RELA(1), SP1(2), STAT5A(3), STAT5B(4) 39874536 47 46 46 16 8 8 14 6 11 0 0.613 1.000 1.000 512 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F12(1), F2(3), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), LPA(7), PLAT(2), PLAU(2), PLG(4), SERPINE1(2), VWF(8) 26821821 47 45 46 17 6 7 19 9 6 0 0.642 1.000 1.000 513 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(3), ACAT1(1), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HADH(1), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), ILVBL(2), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), RDH11(2), RDH12(1), RDH14(1) 31082649 47 45 47 18 3 14 12 14 4 0 0.718 1.000 1.000 514 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(1), AGT(3), CALR(1), CAMK1(2), CAMK1G(1), CREBBP(2), EDN1(2), F2(3), HAND2(2), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(2), MYH2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NPPA(1), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1) 34498308 50 45 50 19 4 7 23 12 4 0 0.769 1.000 1.000 515 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 ADRBK1(1), AKT2(1), AKT3(3), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(2), PLD1(1), PLD3(2) 33977619 51 45 51 16 8 12 11 9 10 1 0.378 1.000 1.000 516 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFAT5(3), PDE6A(1), PDE6B(2), PDE6C(4), PDE6G(1), SLC6A13(2), TF(1) 27843933 44 44 44 16 4 12 8 11 9 0 0.582 1.000 1.000 517 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(3), CAPN2(2), CXCR3(2), EGF(2), EGFR(5), ITGA1(4), ITGB1(2), MAPK1(1), MAPK3(1), MYLK(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTK2(3), PXN(1), TLN1(9) 25719096 45 43 45 17 6 11 14 11 3 0 0.690 1.000 1.000 518 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), AGMAT(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), DAO(1), GATM(4), GOT2(1), MAOA(2), MAOB(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), P4HB(1), RARS(2) 33901569 47 42 47 15 7 10 19 8 3 0 0.448 1.000 1.000 519 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(1), ACAA2(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCAT2(2), BCKDHA(1), DLD(1), ECHS1(1), EHHADH(2), HADH(1), HADHB(1), HIBCH(2), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), IVD(1), MCCC1(2), MUT(1), OXCT1(1), OXCT2(1), PCCA(1), PCCB(1) 32908863 43 42 43 15 4 10 14 11 4 0 0.660 1.000 1.000 520 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CD3E(1), CD3G(1), ELK1(2), GRB2(1), JUN(1), LAT(1), MAP2K1(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(2), ZAP70(1) 30417972 46 42 46 14 9 11 12 7 7 0 0.341 1.000 1.000 521 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(2) 25572573 42 41 42 14 8 9 12 9 4 0 0.531 1.000 1.000 522 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 APC(3), ASAH1(1), DAG1(1), EPHB2(2), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PITX2(2), PTX3(1), RHO(2), RYR1(11) 34570302 42 41 42 19 7 14 7 7 7 0 0.691 1.000 1.000 523 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(2), PLCB1(4), PPP3CA(3), PPP3CB(3), RAF1(1), RELA(1) 27227421 42 40 42 17 7 11 13 9 2 0 0.743 1.000 1.000 524 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), ABO(4), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(4), FUT5(1), GBGT1(1), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1) 37372491 42 40 41 18 6 12 9 9 6 0 0.682 1.000 1.000 525 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 EGF(2), EGFR(5), ETS1(2), ETS2(4), HOXA7(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), RAF1(1), RELA(1), RIPK1(3), SP1(2), TNFRSF1A(1) 34443552 46 40 46 22 7 12 9 13 5 0 0.886 1.000 1.000 526 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 43 AKT2(1), AKT3(3), CAP1(2), CBL(1), F2RL2(1), GRB2(1), GSK3A(1), INPPL1(1), IRS1(1), IRS4(4), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PPYR1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(4), SOS2(2), YWHAB(1) 38845833 42 40 42 21 10 7 15 4 6 0 0.943 1.000 1.000 527 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1B2(1), EEF1D(1), EEF2(2), EEF2K(3), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF4A2(5), EIF4G1(1), EIF4G3(2), EIF5(2), EIF5B(2), ETF1(2), GSPT2(2), KIAA0664(1), PABPC1(3), PABPC3(3), SLC35A4(2) 34177377 43 40 43 14 8 7 13 5 10 0 0.594 1.000 1.000 528 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(3), ARHGAP6(1), ARHGEF1(5), ARHGEF11(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), GSN(1), LIMK1(3), MYLK(6), OPHN1(2), PIP5K1A(1), ROCK1(1), TLN1(9), VCL(3) 35765301 43 38 43 22 7 6 13 6 11 0 0.967 1.000 1.000 529 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG5(1), ALG6(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), GANAB(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), RPN1(2) 31817292 39 36 39 15 3 10 12 7 7 0 0.761 1.000 1.000 530 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(1), AKT3(3), ANKRD6(4), APC(3), AXIN1(1), CER1(1), DKK2(1), DKK3(1), DKK4(1), DVL1(2), GSK3A(1), LRP1(9), MVP(1), NKD1(1), NKD2(2), PSEN1(1), PTPRA(1), SFRP1(3), WIF1(2) 30384510 39 36 39 16 11 7 8 6 7 0 0.706 1.000 1.000 531 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(3), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(2), CHRD(3), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(2), NPPA(1), RFC1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2) 27194973 36 34 35 19 6 7 8 9 6 0 0.950 1.000 1.000 532 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CBX3(2), CLDN5(1), CRY1(1), EIF4G2(1), ETV6(2), HSPA8(3), IDI1(2), MYF6(1), NCKAP1(3), NR1D2(1), PER1(3), PER2(3), PPP2CB(2), TOB1(1), TUBB3(1), UCP3(1), VAPA(1), ZFR(5) 27775488 36 34 36 12 3 8 11 8 6 0 0.631 1.000 1.000 533 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), BTRC(1), CDC23(1), CDC27(1), CUL1(1), CUL3(1), FBXW7(2), ITCH(1), SMURF2(1), UBA1(4), UBE2D2(2), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(6) 31442619 34 34 34 13 8 11 4 6 5 0 0.724 1.000 1.000 534 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(3), EEA1(3), GSK3A(1), LYN(4), PFKM(4), PFKP(4), PLCG1(5), PRKCE(1), PRKCZ(1), VAV2(1) 18957744 36 34 36 14 12 6 7 4 7 0 0.595 1.000 1.000 535 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(1), ACADSB(3), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), MLYCD(2), UPB1(3) 21822801 35 33 35 15 3 10 10 8 4 0 0.779 1.000 1.000 536 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GHR(2), GRB2(1), INSR(2), IRS1(1), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(5), RAF1(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(3), STAT5B(4) 22216740 35 33 35 11 7 7 7 4 10 0 0.401 1.000 1.000 537 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC7(1), CDK2(1), DIAPH2(1), MCM10(2), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), RFC1(2), RFC4(3), RPA1(1) 37681254 33 32 33 15 4 7 10 7 5 0 0.926 1.000 1.000 538 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(3), GSN(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(6), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), TLN1(9) 26271219 35 32 35 12 4 8 10 8 5 0 0.607 1.000 1.000 539 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HIBCH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1) 30260802 33 32 33 12 3 7 12 9 2 0 0.691 1.000 1.000 540 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLB(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLG(1), POLH(2), POLI(3), POLL(1), POLQ(6), REV1(2), REV3L(5) 31857345 34 32 34 11 2 5 12 8 7 0 0.716 1.000 1.000 541 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), BAIAP2(2), CASP1(1), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(7), RERE(2), WWP1(1), WWP2(6) 17922450 36 32 34 13 8 11 2 7 8 0 0.716 1.000 1.000 542 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ATP7A(6), ATP7B(1), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1), SDHA(1), SDHB(1), UQCRC1(2) 29686878 35 32 35 13 8 6 8 6 7 0 0.700 1.000 1.000 543 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(3), COX10(3), COX15(1), CP(2), EARS2(3), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 32345586 33 31 33 15 6 3 14 6 4 0 0.925 1.000 1.000 544 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(1), ARRB2(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKG2(6), PRKX(1) 23608962 31 31 31 19 6 8 7 7 3 0 0.958 1.000 1.000 545 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCKDHA(1), ECHS1(1), EHHADH(2), HADHB(1), IVD(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), PCCB(1) 27494610 32 31 32 14 2 7 12 8 3 0 0.857 1.000 1.000 546 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(2), CTH(3), GGT1(1), LCMT1(1), LCMT2(5), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2) 18848232 35 30 35 13 10 9 9 0 7 0 0.467 1.000 1.000 547 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(4) 24775569 35 30 35 14 6 4 10 4 11 0 0.790 1.000 1.000 548 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 30 BAD(1), CBL(1), CRKL(1), E2F1(2), GRB2(1), IL2RB(1), IL2RG(1), IRS1(1), JAK1(2), JAK3(2), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2) 23659155 31 30 31 14 7 5 5 7 7 0 0.821 1.000 1.000 549 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), L2HGDH(1), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1) 19613295 30 29 30 13 2 9 10 9 0 0 0.776 1.000 1.000 550 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), UPB1(3) 20191275 31 29 31 13 3 7 9 8 4 0 0.781 1.000 1.000 551 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 30 AASDH(1), AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), PLOD1(1), PLOD2(1), PLOD3(2) 26160186 30 29 30 17 3 7 11 5 4 0 0.965 1.000 1.000 552 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 33 CREB1(1), CREB3(1), DUSP10(1), EEF2K(3), ELK1(2), IL1R1(1), MAP2K3(1), MAP3K10(4), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK14(1), MKNK2(1), MYEF2(2), NFKB1(1), NR2C2(1), SRF(1), TRAF6(2) 24306087 31 29 30 15 4 6 12 4 5 0 0.933 1.000 1.000 553 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 23359011 29 28 29 13 3 7 10 7 2 0 0.828 1.000 1.000 554 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), DRD2(1), DRD3(1), DRD4(1), HRH1(1), HRH2(2), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4) 19319742 29 28 29 13 12 0 9 3 5 0 0.753 1.000 1.000 555 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 22 AKT2(1), AKT3(3), BAD(1), GRB2(1), GSK3A(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PPP1R13B(2), RAF1(1), SHC1(1), SOS1(4), SOS2(2), STAT6(1) 23236824 30 28 30 10 6 7 7 4 6 0 0.550 1.000 1.000 556 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 23 ADCY1(3), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(1), MAPK3(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(4) 18378750 27 27 27 13 7 7 4 6 3 0 0.854 1.000 1.000 557 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(3), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1) 25275471 28 27 28 14 1 10 8 7 2 0 0.915 1.000 1.000 558 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 19052046 28 27 28 10 5 7 8 3 5 0 0.533 1.000 1.000 559 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CDK7(2), ERCC3(2), GTF2E2(1), GTF2F2(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(2), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3B(2), POLR3E(2), TAF6(1), TAF7(1), TBP(1) 26354874 29 27 29 14 6 6 7 4 6 0 0.782 1.000 1.000 560 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(2), PLCG1(5), PTK2(3), PXN(1), SHC1(1) 23647494 29 27 29 12 6 7 9 4 3 0 0.730 1.000 1.000 561 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 23 APC(3), AXIN1(1), CCND1(1), CD14(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(1), LBP(1), NFKB1(1), PPP2CA(1), RELA(1), TIRAP(2), TLR4(8) 19312644 27 26 26 14 5 5 3 10 4 0 0.902 1.000 1.000 562 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 EGR2(1), EGR3(3), GNAQ(1), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), NFKBIA(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1) 18461391 26 26 26 11 3 5 6 6 6 0 0.829 1.000 1.000 563 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(2), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY3(1) 19124547 26 25 26 13 4 5 6 6 5 0 0.953 1.000 1.000 564 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), EPHB2(2), F2(3), F2RL2(1), JUN(1), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(2), PLD1(1), PLD3(2), PTK2(3), RAF1(1), RASAL1(2), TEC(1), VAV1(2) 21122127 29 25 29 10 5 7 9 3 5 0 0.545 1.000 1.000 565 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(3), EDN1(2), EDNRA(1), EDNRB(1), EGF(2), EGFR(5), JUN(1), MYC(1), NFKB1(1), PLCG1(5), RELA(1) 15534987 24 24 24 10 3 4 6 7 4 0 0.816 1.000 1.000 566 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(2), ASPA(2), CNDP1(2), DDC(1), HAL(2), MAOA(2), MAOB(1), PRPS2(1) 18594732 28 24 28 10 2 6 13 3 4 0 0.585 1.000 1.000 567 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(1), AOC2(1), AOC3(2), CES1(2), CES7(1), ESCO1(3), LIPA(1), MYST3(2), MYST4(6), PLA1A(2), PNPLA3(1) 19039371 25 24 25 11 4 8 5 4 4 0 0.773 1.000 1.000 568 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), P4HB(1), SLC23A1(2), SLC2A3(2) 20107620 26 24 26 12 6 5 7 6 2 0 0.747 1.000 1.000 569 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(3), COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4) 20047794 25 23 25 12 5 5 6 6 3 0 0.808 1.000 1.000 570 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 25 CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1(1), IGF1R(2), INSR(2), MAPK14(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(1), PPP3CA(3), PPP3CB(3) 22510800 27 23 27 15 1 9 7 6 4 0 0.895 1.000 1.000 571 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), GCDH(1), ITGB1BP3(1), MYST3(2), MYST4(6), PNPLA3(1) 19635603 25 23 25 12 5 5 6 7 2 0 0.833 1.000 1.000 572 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), GOSR1(1), SNAP23(2), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX3(1), STX6(1), STX7(1), TSNARE1(4), USE1(1), VAMP1(1), VAMP3(1), VAMP7(1) 12881856 23 23 23 11 4 3 7 2 7 0 0.896 1.000 1.000 573 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 15 ABCB1(3), ATM(12), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1) 13689000 24 23 24 10 4 5 7 2 6 0 0.877 1.000 1.000 574 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 CDK5(1), CHN1(2), LIMK1(3), MYLK(6), NCF2(2), PAK1(2), PDGFRA(3), PLD1(1), TRIO(2), VAV1(2), WASF1(3) 21829899 27 23 27 16 4 8 9 6 0 0 0.960 1.000 1.000 575 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), CETP(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(9), SCARB1(2), SOAT1(1) 20771790 23 23 23 11 5 6 8 1 3 0 0.826 1.000 1.000 576 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 29 MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), TRAF3(1), TRAF6(2) 22283664 23 22 23 11 5 4 4 4 5 1 0.884 1.000 1.000 577 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(2), IARS(6), IARS2(2), ILVBL(2), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 11908923 23 21 23 10 6 5 6 4 2 0 0.788 1.000 1.000 578 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPN2(2), EP300(3), HDAC1(2), HDAC2(3), NFATC1(1), NFATC2(1), PPP3CA(3), PPP3CB(3) 17986332 23 21 22 13 1 8 4 4 6 0 0.916 1.000 1.000 579 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(1), CREBBP(2), DVL1(2), EP300(3), FZD1(1), HDAC1(2), LDB1(1), PITX2(2), TRRAP(5) 24986988 22 21 21 11 2 3 5 7 5 0 0.915 1.000 1.000 580 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(8), ACTN3(1), CTNNA1(2), CTNNA2(4), PTK2(3), PXN(1), VCL(3) 14958528 22 20 22 12 6 4 6 2 4 0 0.923 1.000 1.000 581 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), AMT(2), ATIC(3), FTCD(1), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5) 14530620 21 20 21 10 1 6 6 3 5 0 0.884 1.000 1.000 582 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2) 17691258 21 20 21 12 4 3 6 4 4 0 0.919 1.000 1.000 583 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), HDAC5(2), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(3), PPP3CB(3), SLC2A4(1) 16291938 21 20 21 11 1 6 4 6 4 0 0.903 1.000 1.000 584 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), AMT(2), ATIC(3), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5) 13721448 20 19 20 10 1 6 6 2 5 0 0.902 1.000 1.000 585 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(3), AXIN1(1), BTRC(1), CCND1(1), CREBBP(2), CSNK2A1(1), DVL1(2), FZD1(1), HDAC1(2), MAP3K7(1), MYC(1), NLK(1), PPP2CA(1), WIF1(2) 22554402 20 19 20 12 2 6 5 4 3 0 0.962 1.000 1.000 586 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 20869134 19 18 19 10 3 1 8 5 2 0 0.914 1.000 1.000 587 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST3(1), DSE(7), UST(2), XYLT1(1), XYLT2(1) 9360741 17 17 17 10 6 5 4 1 1 0 0.874 1.000 1.000 588 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGT(3), ANPEP(4), CTSA(1), CTSG(1), ENPEP(2), MAS1(2), THOP1(1) 16157076 17 17 17 11 2 3 5 4 3 0 0.971 1.000 1.000 589 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(1), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1) 14746095 16 16 16 11 4 2 6 2 2 0 0.979 1.000 1.000 590 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADVL(2), ACSL3(1), ACSL4(2), CPT1A(3), CPT2(3), EHHADH(2), SLC25A20(1) 12761697 14 14 14 8 2 6 5 1 0 0 0.876 1.000 1.000 591 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(6), ABCB4(1), ABCC1(3), ABCC3(1) 11177322 14 14 14 12 2 2 6 2 2 0 0.986 1.000 1.000 592 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 13 CD3E(1), CD3G(1), CD86(2), CTLA4(1), GRB2(1), ICOS(1), IL2(1), ITK(4), PTPN11(1) 6123546 13 13 13 5 2 4 5 2 0 0 0.640 1.000 1.000 593 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(3), AXIN1(1), BTRC(1), DLL1(1), DVL1(2), FZD1(1), NOTCH1(2), PSEN1(1) 16001934 12 12 12 10 1 3 2 5 1 0 0.990 1.000 1.000 594 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), PRKCE(1), SOD1(1) 6005415 11 11 11 5 2 2 4 3 0 0 0.748 1.000 1.000 595 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2) 9291789 11 11 11 9 0 3 6 2 0 0 0.983 1.000 1.000 596 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6035328 8 8 8 5 0 3 5 0 0 0 0.908 1.000 1.000 597 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6035328 8 8 8 5 0 3 5 0 0 0 0.908 1.000 1.000 598 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR109B(1), GPR161(2), GPR34(1), GPR75(1) 7546695 8 8 8 9 0 1 2 5 0 0 0.996 1.000 1.000 599 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(1), SDHB(1) 6033300 7 7 7 6 1 1 2 3 0 0 0.965 1.000 1.000 600 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 MAP2K3(1), MAPK14(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 7832136 7 7 7 8 0 0 5 2 0 0 0.995 1.000 1.000 601 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(1), ATF3(1), CYR61(1), IFRD1(1), IL1A(1), IL1R1(1), NR4A3(1) 8218470 7 7 7 5 2 1 3 1 0 0 0.917 1.000 1.000 602 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 8 CD3E(1), CD3G(1), CD4(2), PTPRC(1), ZAP70(1) 6069297 6 6 6 5 1 3 1 1 0 0 0.890 1.000 1.000 603 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(1), NR0B2(2), NR1H4(1) 4032171 5 5 5 4 1 0 3 1 0 0 0.962 1.000 1.000 604 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCS1(1), HMGCS2(1), OXCT1(1), OXCT2(1) 5437575 5 5 5 4 0 1 2 2 0 0 0.959 1.000 1.000 605 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(1), PTGDR(1), PTGFR(1) 8131266 5 5 5 6 1 0 1 3 0 0 0.995 1.000 1.000 606 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(1), SNAP25(1) 2471625 4 4 4 3 0 0 4 0 0 0 0.917 1.000 1.000 607 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1) 4663386 4 4 4 5 3 0 0 1 0 0 0.979 1.000 1.000 608 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1) 4663386 4 4 4 5 3 0 0 1 0 0 0.979 1.000 1.000 609 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(3), MMP9(1) 5851794 4 4 3 5 1 3 0 0 0 0 0.945 1.000 1.000 610 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 6 CD4(2), IL2(1) 2274909 3 3 3 3 0 1 1 1 0 0 0.931 1.000 1.000 611 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(2) 3768531 3 3 3 4 0 0 1 2 0 0 0.984 1.000 1.000 612 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(2) 1529619 3 3 3 2 0 1 2 0 0 0 0.927 1.000 1.000 613 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 2 CD4(2) 1058109 2 2 2 2 0 1 1 0 0 0 0.881 1.000 1.000 614 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1), ECHS1(1) 4084392 2 2 2 4 0 1 0 1 0 0 0.991 1.000 1.000 615 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), OXCT1(1) 2570490 2 2 2 2 0 1 1 0 0 0 0.957 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 384306 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000