(primary solid tumor cohort)
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MAF used for this analysis:CESC-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 15
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 15. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| PIK3CA | 15190 | 0 | 0 | 11 | 0 | 5.7e-306 | 1.1e-301 |
| NFE2L2 | 7740 | 0 | 0 | 6 | 1 | 4.4e-36 | 4.1e-32 |
| DNAJB1 | 4013 | 0 | 0 | 5 | 1 | 4.8e-17 | 3e-13 |
| FLG | 39325 | 0 | 0 | 7 | 1 | 7.1e-12 | 3.3e-08 |
| TEX15 | 40166 | 0 | 0 | 7 | 0 | 6.2e-09 | 0.000023 |
| DNMBP | 18959 | 0 | 0 | 5 | 2 | 1.4e-08 | 0.000043 |
| MYH9 | 25514 | 0 | 1 | 6 | 2 | 1e-07 | 0.00027 |
| MLL3 | 58314 | 0 | 2 | 10 | 7 | 1.6e-06 | 0.0037 |
| CHD8 | 25927 | 0 | 0 | 5 | 0 | 1.8e-06 | 0.0037 |
| ARID1A | 20952 | 0 | 0 | 6 | 4 | 3.6e-06 | 0.0067 |
| MLL2 | 44628 | 1 | 2 | 7 | 5 | 4.3e-06 | 0.0075 |
| YTHDC1 | 8765 | 0 | 0 | 4 | 0 | 0.000015 | 0.023 |
| BRWD1 | 31388 | 0 | 0 | 5 | 0 | 0.000018 | 0.026 |
| PCLO | 59036 | 0 | 0 | 7 | 1 | 0.000029 | 0.039 |
| ODZ1 | 35119 | 0 | 0 | 5 | 0 | 0.000057 | 0.071 |
| RYR2 | 59155 | 0 | 1 | 8 | 1 | 0.0002 | 0.24 |
| SYNE2 | 96789 | 1 | 0 | 9 | 1 | 0.00024 | 0.26 |
| APOB | 63231 | 0 | 0 | 7 | 0 | 0.00034 | 0.36 |
| PRKDC | 46106 | 1 | 1 | 5 | 1 | 0.00058 | 0.58 |
| SPEN | 40212 | 0 | 0 | 8 | 3 | 0.0009 | 0.85 |
| AGBL5 | 10205 | 0 | 4 | 6 | 2 | 0.0011 | 0.99 |
| SRRM2 | 26028 | 0 | 0 | 5 | 1 | 0.0014 | 1 |
| FAT2 | 53153 | 0 | 2 | 5 | 1 | 0.0016 | 1 |
| ARFGEF2 | 23705 | 1 | 1 | 4 | 0 | 0.0058 | 1 |
| NOTCH1 | 19555 | 0 | 2 | 6 | 1 | 0.0065 | 1 |
| PTPN13 | 27104 | 0 | 1 | 5 | 0 | 0.015 | 1 |
| CELSR2 | 29059 | 0 | 1 | 6 | 1 | 0.021 | 1 |
| SRCAP | 29937 | 0 | 0 | 7 | 0 | 0.038 | 1 |
| PLEC | 39253 | 2 | 2 | 7 | 0 | 0.04 | 1 |
| ADAMTS16 | 13813 | 1 | 0 | 4 | 0 | 0.041 | 1 |
| FNDC1 | 14359 | 0 | 0 | 4 | 0 | 0.046 | 1 |
| NRIP1 | 14813 | 0 | 0 | 4 | 0 | 0.05 | 1 |
| TIE1 | 11414 | 0 | 0 | 4 | 1 | 0.052 | 1 |
| ZBTB38 | 15552 | 1 | 0 | 5 | 0 | 0.059 | 1 |
| TTN | 459166 | 2 | 9 | 29 | 2 | 0.059 | 1 |
