Glioblastoma Multiforme: Mutation Analysis (MutSig vS2N)
(primary solid tumor cohort)
Maintained by Dan DiCara (Broad Institute)
- Overview
+ Introduction
- Summary
- Results
- Significantly Mutated Genes

Column Descriptions:

  • N = number of sequenced bases in this gene across the individual set

  • nnon = number of (nonsilent) mutations in this gene across the individual set

  • nnull = number of (nonsilent) null mutations in this gene across the individual set

  • nflank = number of noncoding mutations from this gene's flanking region, across the individual set

  • nsil = number of silent mutations in this gene across the individual set

  • p = p-value (overall)

  • q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

Table 1.  Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 93. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

gene N nflank nsil nnon nnull p q
PTEN 46851 0 0 93 43 0 0
RB1 141717 0 1 24 23 0 0
PIK3R1 85845 0 0 34 20 1.1e-205 7.2e-202
TP53 36666 0 1 100 19 1.9e-194 9.1e-191
RPL5 33756 0 0 8 6 3.5e-169 1.3e-165
IDH1 46560 0 0 15 0 1.3e-126 4e-123
PIK3CA 122511 0 0 35 7 5.6e-111 1.5e-107
STAG2 144627 0 0 12 10 1.3e-95 3.1e-92
CDC27 87009 0 0 7 6 4.3e-66 9e-63
C3orf67 59073 0 0 6 0 1.5e-55 2.9e-52
NF1 434463 0 1 34 28 1.8e-46 3.2e-43
PRB2 19788 0 0 6 6 1.1e-45 1.7e-42
SLC22A9 59364 0 0 5 0 2.3e-34 3.3e-31
LZTR1 74787 0 0 10 1 1.3e-33 1.8e-30
PDGFRA 120183 0 1 13 2 3.7e-33 4.6e-30
EGFR 132987 0 7 95 5 4e-25 4.7e-22
CHD8 213012 0 0 10 7 7.6e-23 8e-20
SEMA3C 82644 0 1 11 1 7.7e-23 8e-20
SEMG1 48597 0 0 8 1 6.7e-22 6.7e-19
DYNC1I1 63729 0 0 7 1 3.9e-19 3.7e-16
KDR 145500 0 0 9 3 1.4e-14 1.2e-11
ADAM29 88173 0 1 9 1 3.7e-14 3.2e-11
ATRX 279942 0 2 17 12 1.7e-12 1.4e-09
RBM47 48888 0 3 9 0 3.1e-12 2.5e-09
CARD6 104760 0 0 7 1 6.3e-12 4.8e-09
CALCR 54999 0 0 8 0 8.4e-12 6.1e-09
SULT1B1 35793 0 1 7 1 1.1e-11 7.6e-09
COL4A4 107670 0 1 7 0 1.3e-11 8.6e-09
KIAA1751 72168 0 1 6 0 1.8e-11 1.2e-08
QKI 37248 0 0 5 3 1.9e-11 1.2e-08
MYO1B 131532 0 0 7 0 8.2e-11 5e-08
KEL 78570 0 2 15 3 8e-10 4.7e-07
PROKR2 42486 0 0 7 0 8.4e-10 4.8e-07
BRAF 75951 0 1 6 0 1.3e-09 7.2e-07
F5 239784 0 0 9 3 3.9e-09 2.1e-06
+ Methods & Data
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