E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.158 -9999.0 0.0 -0.389 25.0 25.0 KLHL20 0.021 0.098 0.181 11.0 -0.218 5.0 16.0 CYFIP2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.017 0.102 0.22 1.0 -0.254 19.0 20.0 ENAH -0.044 0.155 -9999.0 0.0 -0.394 23.0 23.0 AP1M1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.005 0.082 -9999.0 0.0 -0.296 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.044 -9999.0 0.0 -0.15 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.11 -9999.0 0.0 -0.213 24.0 24.0 RAPGEF1 -0.038 0.148 0.221 1.0 -0.371 21.0 22.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.165 -9999.0 0.0 -0.396 25.0 25.0 CRK -0.043 0.152 -9999.0 0.0 -0.387 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.109 -9999.0 0.0 -0.231 23.0 23.0 alphaE/beta7 Integrin 0.042 0.039 -9999.0 0.0 -0.26 2.0 2.0 IQGAP1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.053 0.025 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.046 0.158 -9999.0 0.0 -0.394 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.045 -9999.0 0.0 -0.142 20.0 20.0 MLLT4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.058 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.043 0.058 -9999.0 0.0 -0.18 20.0 20.0 ARF6 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.006 0.116 -9999.0 0.0 -0.272 23.0 23.0 TIAM1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.031 0.1 -9999.0 0.0 -0.198 23.0 23.0 AKT1 -0.017 0.052 0.149 1.0 -0.163 1.0 2.0 PIK3R1 0.029 0.035 -9999.0 0.0 -0.38 1.0 1.0 CDH1 -0.036 0.149 -9999.0 0.0 -0.38 23.0 23.0 RhoA/GDP -0.012 0.116 0.221 1.0 -0.253 21.0 22.0 actin cytoskeleton organization 0.019 0.077 0.15 11.0 -0.166 4.0 15.0 CDC42/GDP -0.012 0.115 0.221 1.0 -0.253 21.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.017 0.084 -9999.0 0.0 -0.205 24.0 24.0 ITGB7 0.027 0.048 -9999.0 0.0 -0.38 2.0 2.0 RAC1 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.034 0.108 -9999.0 0.0 -0.211 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.013 0.092 -9999.0 0.0 -0.193 23.0 23.0 mol:GDP -0.029 0.122 0.22 1.0 -0.287 21.0 22.0 CDC42/GTP/IQGAP1 0.044 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.001 0.123 0.231 1.0 -0.26 21.0 22.0 RAC1/GTP/IQGAP1 0.031 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.045 0.028 -9999.0 0.0 -0.27 1.0 1.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.054 0.113 10.0 -0.119 2.0 12.0 NME1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.044 0.157 -9999.0 0.0 -0.4 23.0 23.0 regulation of cell-cell adhesion -0.014 0.065 -9999.0 0.0 -0.26 1.0 1.0 WASF2 0.008 0.042 0.094 5.0 -9999.0 0.0 5.0 Rap1/GTP -0.004 0.091 0.17 7.0 -0.201 20.0 27.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.112 -9999.0 0.0 -0.204 24.0 24.0 CCND1 0.017 0.063 0.13 10.0 -0.145 2.0 12.0 VAV2 -0.048 0.212 -9999.0 0.0 -0.672 8.0 8.0 RAP1/GDP -0.001 0.1 -9999.0 0.0 -0.373 1.0 1.0 adherens junction assembly -0.042 0.153 -9999.0 0.0 -0.388 23.0 23.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.034 -9999.0 0.0 -0.38 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.016 0.101 -9999.0 0.0 -0.2 24.0 24.0 E-cadherin/beta catenin -0.042 0.11 -9999.0 0.0 -0.294 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.155 -9999.0 0.0 -0.393 23.0 23.0 PIK3CA 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.033 0.1 -9999.0 0.0 -0.348 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.013 0.108 -9999.0 0.0 -0.23 23.0 23.0 ITGAE 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.037 0.168 -9999.0 0.0 -0.404 25.0 25.0