(primary solid tumor cohort)
-
MAF used for this analysis:HNSC-TP.final_analysis_set.maf
-
Significantly mutated genes (q ≤ 0.1): 61
Column Descriptions:
-
N = number of sequenced bases in this gene across the individual set
-
nnon = number of (nonsilent) mutations in this gene across the individual set
-
nnull = number of (nonsilent) null mutations in this gene across the individual set
-
nflank = number of noncoding mutations from this gene's flanking region, across the individual set
-
nsil = number of silent mutations in this gene across the individual set
-
p = p-value (overall)
-
q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 61. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| ZNF737 | 848 | 0 | 2 | 11 | 2 | 0 | 0 |
| POTEC | 764 | 0 | 1 | 15 | 1 | 0 | 0 |
| KRTAP4-11 | 184 | 0 | 2 | 7 | 0 | 0 | 0 |
| PRAMEF11 | 624 | 0 | 0 | 10 | 0 | 0 | 0 |
| ANKRD30B | 964 | 0 | 1 | 10 | 2 | 0 | 0 |
| ZNF844 | 644 | 0 | 0 | 6 | 0 | 0 | 0 |
| CDKN2A | 18272 | 0 | 0 | 62 | 49 | 0 | 0 |
| FAM75C1 | 1340 | 0 | 0 | 10 | 2 | 0 | 0 |
| NBPF9 | 1208 | 0 | 1 | 9 | 2 | 0 | 0 |
| ZNF716 | 724 | 0 | 2 | 7 | 0 | 0 | 0 |
| DCAF8L2 | 424 | 0 | 1 | 5 | 0 | 0 | 0 |
| RGPD4 | 1784 | 0 | 1 | 8 | 3 | 0 | 0 |
| TP53 | 38556 | 0 | 5 | 244 | 95 | 2e-286 | 2.9e-283 |
| ZNF860 | 1532 | 0 | 0 | 5 | 0 | 2.3e-103 | 3.1e-100 |
| JUB | 32738 | 0 | 1 | 18 | 12 | 8.2e-86 | 1e-82 |
| PIK3CA | 128834 | 0 | 0 | 64 | 0 | 8.1e-76 | 9.5e-73 |
| CT47B1 | 284 | 0 | 3 | 4 | 1 | 2.3e-48 | 2.6e-45 |
| UBTFL1 | 400 | 0 | 0 | 4 | 0 | 1.1e-39 | 1.2e-36 |
| FAM75A6 | 1100 | 0 | 4 | 13 | 0 | 4.6e-38 | 4.6e-35 |
| FAT1 | 498120 | 0 | 2 | 88 | 66 | 6.4e-38 | 6e-35 |
| MLL2 | 382710 | 0 | 3 | 59 | 37 | 5.5e-29 | 4.9e-26 |
| TGFBR2 | 65790 | 0 | 1 | 11 | 7 | 4.5e-28 | 3.9e-25 |
| ZNF286B | 696 | 0 | 0 | 4 | 0 | 3.5e-26 | 2.9e-23 |
| NSD1 | 276934 | 0 | 1 | 38 | 24 | 5.4e-25 | 4.2e-22 |
| EYS | 68854 | 0 | 2 | 13 | 0 | 6.2e-23 | 4.7e-20 |
| HLA-A | 33044 | 0 | 2 | 9 | 8 | 1.6e-22 | 1.1e-19 |
| NOTCH1 | 159614 | 0 | 5 | 60 | 23 | 1e-20 | 7.2e-18 |
| TRIP11 | 235306 | 0 | 3 | 20 | 1 | 3.8e-15 | 2.5e-12 |
| CASP8 | 71910 | 0 | 0 | 25 | 13 | 1.2e-13 | 7.6e-11 |
| RGPD3 | 1676 | 0 | 1 | 4 | 1 | 2.6e-12 | 1.6e-09 |
| ZNF845 | 1472 | 0 | 4 | 7 | 0 | 4.8e-12 | 2.9e-09 |
| HRAS | 20820 | 0 | 0 | 11 | 0 | 7e-12 | 4.1e-09 |
| ANKRD36 | 15262 | 0 | 3 | 5 | 1 | 3.9e-11 | 2.2e-08 |
| EPHA2 | 92738 | 0 | 0 | 17 | 10 | 4.6e-11 | 2.5e-08 |
| CD248 | 48054 | 0 | 2 | 14 | 0 | 1.4e-08 | 7.7e-06 |
