Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.17 -9999.0 0.0 -0.579 2.0 2.0 IHH -0.087 0.284 -9999.0 0.0 -0.902 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.196 0.263 -9999.0 0.0 -0.552 23.0 23.0 LRPAP1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.195 0.261 0.547 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.081 0.224 -9999.0 0.0 -0.664 7.0 7.0 SMO -0.084 0.236 -9999.0 0.0 -0.705 7.0 7.0 AKT1 -0.02 0.095 -9999.0 0.0 -0.333 1.0 1.0 ARRB2 -0.006 0.049 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.082 0.231 -9999.0 0.0 -0.69 7.0 7.0 STIL -0.153 0.276 -9999.0 0.0 -0.537 19.0 19.0 DHH N/PTCH2 -0.052 0.182 -9999.0 0.0 -0.682 5.0 5.0 DHH N/PTCH1 -0.074 0.216 -9999.0 0.0 -0.524 12.0 12.0 PIK3CA 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.059 0.235 -9999.0 0.0 -0.873 5.0 5.0 PTHLH -0.037 0.198 -9999.0 0.0 -0.703 2.0 2.0 determination of left/right symmetry -0.082 0.231 -9999.0 0.0 -0.69 7.0 7.0 PIK3R1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.037 0.196 -9999.0 0.0 -0.696 2.0 2.0 IHH N/Hhip -0.055 0.194 -9999.0 0.0 -0.613 7.0 7.0 DHH N/Hhip -0.052 0.182 -9999.0 0.0 -0.682 5.0 5.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.082 0.231 -9999.0 0.0 -0.69 7.0 7.0 pancreas development 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.062 0.235 -9999.0 0.0 -0.873 5.0 5.0 somite specification -0.082 0.231 -9999.0 0.0 -0.69 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.166 0.29 -9999.0 0.0 -0.551 22.0 22.0 SHH Np/Cholesterol/PTCH2 -0.153 0.247 -9999.0 0.0 -0.551 18.0 18.0 SHH Np/Cholesterol/Megalin -0.552 0.342 -9999.0 0.0 -0.69 52.0 52.0 SHH -0.18 0.311 -9999.0 0.0 -0.682 18.0 18.0 catabolic process -0.036 0.182 -9999.0 0.0 -0.557 7.0 7.0 SMO/Vitamin D3 -0.17 0.3 -9999.0 0.0 -0.562 22.0 22.0 SHH Np/Cholesterol/Hhip -0.153 0.247 -9999.0 0.0 -0.552 18.0 18.0 LRP2 -0.643 0.386 -9999.0 0.0 -0.873 48.0 48.0 receptor-mediated endocytosis -0.433 0.321 -9999.0 0.0 -0.825 22.0 22.0 SHH Np/Cholesterol/BOC -0.153 0.247 -9999.0 0.0 -0.551 18.0 18.0 SHH Np/Cholesterol/CDO -0.154 0.246 -9999.0 0.0 -0.551 18.0 18.0 mesenchymal cell differentiation 0.152 0.245 0.547 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.164 0.291 -9999.0 0.0 -0.55 22.0 22.0 IHH N/PTCH2 -0.053 0.194 -9999.0 0.0 -0.61 7.0 7.0 CDON 0.005 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.036 0.185 -9999.0 0.0 -0.565 7.0 7.0 Megalin/LRPAP1 -0.503 0.299 -9999.0 0.0 -0.681 48.0 48.0 PTCH2 0.008 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.154 0.249 -9999.0 0.0 -0.557 18.0 18.0 PTCH1 -0.037 0.183 -9999.0 0.0 -0.559 7.0 7.0 HHIP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0