Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.006 0.114 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.04 0.215 -9999.0 0.0 -0.656 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.109 0.186 -9999.0 0.0 -0.378 21.0 21.0 LRPAP1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.109 0.184 0.375 21.0 -9999.0 0.0 21.0 SMO/beta Arrestin2 -0.047 0.174 -9999.0 0.0 -0.517 6.0 6.0 SMO -0.062 0.177 -9999.0 0.0 -0.519 7.0 7.0 AKT1 -0.014 0.086 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.024 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.061 0.174 -9999.0 0.0 -0.51 7.0 7.0 STIL -0.098 0.181 -9999.0 0.0 -0.383 14.0 14.0 DHH N/PTCH2 -0.007 0.135 -9999.0 0.0 -0.472 5.0 5.0 DHH N/PTCH1 -0.034 0.153 -9999.0 0.0 -0.351 12.0 12.0 PIK3CA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.028 0.174 -9999.0 0.0 -0.632 5.0 5.0 PTHLH -0.019 0.139 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.061 0.174 -9999.0 0.0 -0.51 7.0 7.0 PIK3R1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.018 0.138 -9999.0 0.0 -0.428 4.0 4.0 IHH N/Hhip -0.014 0.141 -9999.0 0.0 -0.419 7.0 7.0 DHH N/Hhip -0.009 0.135 -9999.0 0.0 -0.476 5.0 5.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.061 0.174 -9999.0 0.0 -0.51 7.0 7.0 pancreas development 0.011 0.018 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.027 0.175 -9999.0 0.0 -0.632 5.0 5.0 somite specification -0.061 0.174 -9999.0 0.0 -0.51 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.098 0.191 -9999.0 0.0 -0.375 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.079 0.17 -9999.0 0.0 -0.376 16.0 16.0 SHH Np/Cholesterol/Megalin -0.355 0.227 -9999.0 0.0 -0.451 51.0 51.0 SHH -0.126 0.2 -9999.0 0.0 -0.475 16.0 16.0 catabolic process -0.014 0.127 -9999.0 0.0 -0.372 7.0 7.0 SMO/Vitamin D3 -0.111 0.206 -9999.0 0.0 -0.559 6.0 6.0 SHH Np/Cholesterol/Hhip -0.081 0.165 -9999.0 0.0 -0.377 15.0 15.0 LRP2 -0.459 0.282 -9999.0 0.0 -0.625 48.0 48.0 receptor-mediated endocytosis -0.298 0.243 -9999.0 0.0 -0.598 20.0 20.0 SHH Np/Cholesterol/BOC -0.079 0.17 -9999.0 0.0 -0.377 16.0 16.0 SHH Np/Cholesterol/CDO -0.079 0.171 -9999.0 0.0 -0.377 16.0 16.0 mesenchymal cell differentiation 0.08 0.164 0.375 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 -0.096 0.193 -9999.0 0.0 -0.374 19.0 19.0 IHH N/PTCH2 -0.01 0.141 -9999.0 0.0 -0.414 7.0 7.0 CDON 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.006 0.131 -9999.0 0.0 -0.376 7.0 7.0 Megalin/LRPAP1 -0.329 0.221 -9999.0 0.0 -0.457 48.0 48.0 PTCH2 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.09 0.162 -9999.0 0.0 -0.374 16.0 16.0 PTCH1 -0.014 0.127 -9999.0 0.0 -0.373 7.0 7.0 HHIP 0.011 0.018 -9999.0 0.0 -9999.0 0.0 0.0