Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	35.0	1208.0	34.0	-0.555	0.028	1000.0	-1000.0	-0.037	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1150.0	46.0	-1.216	0.025	1000.0	-1000.0	-0.085	-1000.0
PDGFR-alpha signaling pathway	16.0	728.0	44.0	-0.243	0.033	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by the Hedgehog family	9.0	496.0	52.0	-0.459	0.109	1000.0	-1000.0	-0.042	-1000.0
Glypican 1 network	8.0	405.0	48.0	-0.304	0.05	1000.0	-1000.0	-0.036	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	679.0	82.0	-0.144	0.031	1000.0	-1000.0	-0.059	-1000.0
BMP receptor signaling	7.0	568.0	81.0	-0.504	0.044	1000.0	-1000.0	-0.053	-1000.0
Thromboxane A2 receptor signaling	6.0	676.0	105.0	-0.149	0.04	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	6.0	291.0	48.0	-0.192	0.046	1000.0	-1000.0	-0.031	-1000.0
HIF-1-alpha transcription factor network	5.0	444.0	76.0	-0.827	0.032	1000.0	-1000.0	-0.1	-1000.0
Reelin signaling pathway	5.0	286.0	56.0	-0.101	0.058	1000.0	-1000.0	-0.043	-1000.0
Endothelins	5.0	486.0	96.0	-0.572	0.029	1000.0	-1000.0	-0.049	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	399.0	68.0	-0.481	0.08	1000.0	-1000.0	-0.086	-1000.0
IL23-mediated signaling events	5.0	302.0	60.0	-0.284	0.07	1000.0	-1000.0	-0.095	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	624.0	120.0	-0.385	0.151	1000.0	-1000.0	-0.051	-1000.0
ErbB2/ErbB3 signaling events	4.0	302.0	65.0	-0.071	0.075	1000.0	-1000.0	-0.063	-1000.0
amb2 Integrin signaling	4.0	343.0	82.0	-0.421	0.04	1000.0	-1000.0	-0.048	-1000.0
Syndecan-1-mediated signaling events	3.0	103.0	34.0	-0.175	0.034	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	169.0	54.0	-0.101	0.072	1000.0	-1000.0	-0.054	-1000.0
IL4-mediated signaling events	3.0	357.0	91.0	-0.488	0.301	1000.0	-1000.0	-0.11	-1000.0
FoxO family signaling	3.0	229.0	64.0	-0.658	0.064	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	3.0	286.0	86.0	-0.085	0.079	1000.0	-1000.0	-0.053	-1000.0
FOXM1 transcription factor network	3.0	178.0	51.0	-0.18	0.112	1000.0	-1000.0	-0.108	-1000.0
Circadian rhythm pathway	2.0	62.0	22.0	-0.297	0.029	1000.0	-1000.0	-0.027	-1000.0
Syndecan-2-mediated signaling events	2.0	138.0	69.0	-0.421	0.042	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by PTP1B	2.0	212.0	76.0	-0.341	0.042	1000.0	-1000.0	-0.042	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	260.0	97.0	-0.09	0.045	1000.0	-1000.0	-0.062	-1000.0
Glucocorticoid receptor regulatory network	2.0	283.0	114.0	-0.289	0.102	1000.0	-1000.0	-0.049	-1000.0
IL1-mediated signaling events	2.0	155.0	62.0	-0.249	0.059	1000.0	-1000.0	-0.072	-1000.0
ceramide signaling pathway	2.0	119.0	49.0	-0.02	0.04	1000.0	-1000.0	-0.047	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	122.0	52.0	-0.366	0.076	1000.0	-1000.0	-0.048	-1000.0
FAS signaling pathway (CD95)	2.0	101.0	47.0	-0.25	0.04	1000.0	-1000.0	-0.041	-1000.0
Syndecan-3-mediated signaling events	2.0	95.0	35.0	-0.058	0.059	1000.0	-1000.0	-0.033	-1000.0
Integrins in angiogenesis	2.0	242.0	84.0	-0.477	0.073	1000.0	-1000.0	-0.055	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	222.0	93.0	-0.034	0.052	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	2.0	57.0	26.0	-0.2	0.072	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	2.0	143.0	52.0	-0.056	0.04	1000.0	-1000.0	-0.038	-1000.0
TCGA08_rtk_signaling	2.0	59.0	26.0	-0.24	0.029	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	2.0	264.0	102.0	-0.054	0.033	1000.0	-1000.0	-0.052	-1000.0
IL6-mediated signaling events	2.0	157.0	75.0	-0.117	0.037	1000.0	-1000.0	-0.052	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	175.0	74.0	-0.228	0.056	1000.0	-1000.0	-0.07	-1000.0
EGFR-dependent Endothelin signaling events	2.0	46.0	21.0	-0.036	0.034	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	183.0	88.0	-0.152	0.031	1000.0	-1000.0	-0.086	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.036	0.038	1000.0	-1000.0	-0.028	-1000.0
LPA4-mediated signaling events	1.0	12.0	12.0	-0.052	0.014	1000.0	-1000.0	-0.025	-1000.0
Caspase cascade in apoptosis	1.0	90.0	74.0	-0.028	0.042	1000.0	-1000.0	-0.042	-1000.0
Coregulation of Androgen receptor activity	1.0	92.0	76.0	-0.091	0.125	1000.0	-1000.0	-0.027	-1000.0
ErbB4 signaling events	1.0	83.0	69.0	-0.073	0.075	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Cones	1.0	44.0	38.0	-0.07	0.078	1000.0	-1000.0	-0.027	-1000.0
Osteopontin-mediated events	1.0	60.0	38.0	-0.319	0.041	1000.0	-1000.0	-0.047	-1000.0
Ephrin A  reverse signaling	1.0	9.0	7.0	-0.007	0.021	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	24.0	17.0	-0.059	0.067	1000.0	-1000.0	-0.038	-1000.0
Noncanonical Wnt signaling pathway	1.0	45.0	26.0	-0.088	0.03	1000.0	-1000.0	-0.043	-1000.0
Arf6 signaling events	1.0	107.0	62.0	-0.019	0.054	1000.0	-1000.0	-0.039	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	90.0	85.0	-0.038	0.05	1000.0	-1000.0	-0.046	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	81.0	65.0	-0.017	0.067	1000.0	-1000.0	-0.048	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	100.0	61.0	-0.239	0.059	1000.0	-1000.0	-0.053	-1000.0
p75(NTR)-mediated signaling	1.0	203.0	125.0	-0.261	0.082	1000.0	-1000.0	-0.068	-1000.0
PLK1 signaling events	1.0	154.0	85.0	-0.01	0.069	1000.0	-1000.0	-0.044	-1000.0
IFN-gamma pathway	1.0	76.0	68.0	-0.167	0.062	1000.0	-1000.0	-0.061	-1000.0
Nectin adhesion pathway	1.0	73.0	63.0	-0.018	0.06	1000.0	-1000.0	-0.047	-1000.0
Ceramide signaling pathway	1.0	79.0	76.0	-0.029	0.057	1000.0	-1000.0	-0.045	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	49.0	37.0	-0.094	0.062	1000.0	-1000.0	-0.04	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	88.0	83.0	-0.15	0.044	1000.0	-1000.0	-0.049	-1000.0
S1P1 pathway	1.0	51.0	36.0	-0.025	0.024	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by PI3K	1.0	88.0	58.0	-0.066	0.043	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	74.0	44.0	-0.173	0.044	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	55.0	45.0	-0.022	0.058	1000.0	-1000.0	-0.053	-1000.0
Regulation of p38-alpha and p38-beta	1.0	65.0	54.0	-0.058	0.052	1000.0	-1000.0	-0.057	-1000.0
BCR signaling pathway	1.0	191.0	99.0	-0.023	0.067	1000.0	-1000.0	-0.06	-1000.0
Syndecan-4-mediated signaling events	1.0	86.0	67.0	-0.247	0.043	1000.0	-1000.0	-0.04	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	49.0	33.0	-0.028	0.078	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Rods	1.0	88.0	52.0	-0.07	0.06	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PRL	1.0	43.0	34.0	-0.047	0.032	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	1.0	83.0	43.0	-0.188	0.026	1000.0	-1000.0	-0.043	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.018	0.019	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.001	0.025	1000.0	-1000.0	0.002	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	114.0	78.0	-0.168	0.103	1000.0	-1000.0	-0.046	-1000.0
Aurora B signaling	1.0	85.0	67.0	-0.306	0.095	1000.0	-1000.0	-0.042	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	122.0	136.0	-0.234	0.078	1000.0	-1000.0	-0.043	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	-0.004	0.047	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	0.0	2.0	39.0	-0.004	0.048	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	0.0	12.0	75.0	-0.024	0.064	1000.0	-1000.0	-0.04	-1000.0
IL12-mediated signaling events	0.0	30.0	87.0	-0.054	0.115	1000.0	-1000.0	-0.08	-1000.0
BARD1 signaling events	0.0	24.0	57.0	-0.044	0.052	1000.0	-1000.0	-0.05	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	4.0	28.0	-0.008	0.044	1000.0	-1000.0	-0.03	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.009	-1000.0	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.021	0.032	1000.0	-1000.0	0.003	-1000.0
Cellular roles of Anthrax toxin	0.0	38.0	39.0	-0.083	0.03	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	0.0	2.0	60.0	-0.0	0.055	1000.0	-1000.0	-0.031	-1000.0
Arf6 downstream pathway	0.0	0.0	43.0	-0.041	0.043	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	0.0	0.0	7.0	0.0	0.047	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	0.0	30.0	55.0	-0.015	0.067	1000.0	-1000.0	-0.039	-1000.0
Insulin-mediated glucose transport	0.0	29.0	32.0	-0.112	0.04	1000.0	-1000.0	-0.034	-1000.0
mTOR signaling pathway	0.0	39.0	53.0	-0.042	0.033	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	43.0	68.0	-0.112	0.043	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by HDAC Class III	0.0	16.0	40.0	-0.04	0.042	1000.0	-1000.0	-0.029	-1000.0
TRAIL signaling pathway	0.0	20.0	48.0	-0.011	0.058	1000.0	-1000.0	-0.037	-1000.0
S1P5 pathway	0.0	3.0	17.0	-0.019	0.031	1000.0	-1000.0	-0.015	-1000.0
HIF-2-alpha transcription factor network	0.0	16.0	43.0	-0.076	0.078	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class I	0.0	25.0	104.0	-0.044	0.055	1000.0	-1000.0	-0.042	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.03	0.022	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	10.0	15.0	-0.031	0.025	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	0.0	45.0	58.0	-0.003	0.044	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	26.0	36.0	-0.094	0.043	1000.0	-1000.0	-0.054	-1000.0
Atypical NF-kappaB pathway	0.0	20.0	31.0	-0.01	0.033	1000.0	-1000.0	-0.03	-1000.0
Canonical Wnt signaling pathway	0.0	45.0	51.0	-0.081	0.065	1000.0	-1000.0	-0.061	-1000.0
EPHB forward signaling	0.0	54.0	85.0	-0.04	0.063	1000.0	-1000.0	-0.068	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.024	0.037	1000.0	-1000.0	-0.002	-1000.0
Calcium signaling in the CD4+ TCR pathway	0.0	6.0	31.0	-0.004	0.046	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	47.0	125.0	-0.028	0.056	1000.0	-1000.0	-0.057	-1000.0
IL27-mediated signaling events	0.0	32.0	51.0	-0.118	0.069	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	0.0	4.0	7.0	0.003	0.03	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	72.0	76.0	-0.025	0.044	1000.0	-1000.0	-0.067	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.011	0.054	1000.0	-1000.0	-0.045	-1000.0
IL2 signaling events mediated by STAT5	0.0	11.0	22.0	-0.008	0.039	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events	0.0	59.0	73.0	-0.023	0.067	1000.0	-1000.0	-0.053	-1000.0
Arf6 trafficking events	0.0	31.0	71.0	-0.046	0.073	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	0.0	0.0	8.0	-0.023	0.079	1000.0	-1000.0	-0.007	-1000.0
Regulation of Telomerase	0.0	65.0	102.0	-0.242	0.074	1000.0	-1000.0	-0.052	-1000.0
IGF1 pathway	0.0	5.0	57.0	-0.009	0.075	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	0.0	27.0	74.0	-0.053	0.059	1000.0	-1000.0	-0.059	-1000.0
VEGFR1 specific signals	0.0	14.0	56.0	-0.035	0.052	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.0	0.036	1000.0	-1000.0	-0.035	-1000.0
Rapid glucocorticoid signaling	0.0	0.0	20.0	-0.0	0.041	1000.0	-1000.0	-0.016	-1000.0
PDGFR-beta signaling pathway	0.0	70.0	97.0	-0.026	0.062	1000.0	-1000.0	-0.06	-1000.0
S1P4 pathway	0.0	5.0	25.0	-0.008	0.04	1000.0	-1000.0	-0.029	-1000.0
p38 MAPK signaling pathway	0.0	11.0	44.0	-0.004	0.06	1000.0	-1000.0	-0.033	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.011	0.044	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.06	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	56.0	70.0	-0.063	0.087	1000.0	-1000.0	-0.051	-1000.0
Total	253	17692	7203	-17.8341152408	-992.763228188	131000	-131000	-5.7549123807	-131000