(primary solid tumor cohort)
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MAF used for this analysis:KIRC-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 11
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 11. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| PBRM1 | 184917 | 7 | 1 | 110 | 88 | 9.6e-288 | 1.8e-283 |
| VHL | 13049 | 2 | 5 | 140 | 86 | 2.2e-261 | 2.1e-257 |
| KIAA1731 | 2502 | 2 | 1 | 5 | 0 | 9.4e-145 | 5.9e-141 |
| BAP1 | 69308 | 2 | 1 | 28 | 16 | 1.6e-83 | 7.4e-80 |
| SETD2 | 222244 | 4 | 1 | 37 | 24 | 6.5e-48 | 2.4e-44 |
| KDM5C | 121556 | 1 | 0 | 18 | 12 | 3.6e-26 | 1.1e-22 |
| PTEN | 46149 | 3 | 0 | 10 | 6 | 7.2e-15 | 1.9e-11 |
| EBPL | 17820 | 0 | 0 | 8 | 0 | 4.4e-07 | 0.001 |
| MUC17 | 403288 | 0 | 3 | 18 | 0 | 2.9e-06 | 0.006 |
| WDR52 | 119653 | 6 | 1 | 10 | 0 | 8.3e-06 | 0.016 |
| TP53 | 37422 | 1 | 1 | 7 | 1 | 0.000014 | 0.025 |
| UNC80 | 28790 | 4 | 1 | 5 | 0 | 7e-05 | 0.11 |
| MTOR | 303793 | 6 | 2 | 26 | 0 | 0.000078 | 0.11 |
| CR1 | 154851 | 2 | 0 | 10 | 5 | 0.0005 | 0.67 |
| ANKRD30B | 66998 | 4 | 1 | 5 | 0 | 0.00057 | 0.72 |
| MUC2 | 174261 | 1 | 2 | 11 | 1 | 0.00083 | 0.98 |
| GRIN2B | 160955 | 5 | 1 | 11 | 0 | 0.0035 | 1 |
| ZNF799 | 67438 | 2 | 1 | 8 | 1 | 0.004 | 1 |
| SFRS15 | 101239 | 1 | 0 | 9 | 3 | 0.0053 | 1 |
| ACSBG2 | 76291 | 2 | 1 | 5 | 0 | 0.0062 | 1 |
| DNAH6 | 50319 | 4 | 2 | 5 | 0 | 0.009 | 1 |
| MUC16 | 1369897 | 8 | 10 | 36 | 1 | 0.0094 | 1 |
| NBPF10 | 104806 | 47 | 5 | 25 | 0 | 0.0098 | 1 |
| HSPA8 | 69182 | 0 | 3 | 6 | 2 | 0.012 | 1 |
| DNAH9 | 474903 | 7 | 0 | 17 | 3 | 0.013 | 1 |
| PIK3CA | 125593 | 3 | 0 | 10 | 1 | 0.015 | 1 |
| MUC4 | 190073 | 8 | 17 | 63 | 3 | 0.018 | 1 |
| MCM7 | 81637 | 0 | 0 | 6 | 1 | 0.02 | 1 |
| COL11A1 | 145416 | 6 | 1 | 8 | 5 | 0.021 | 1 |
| ABCB1 | 161252 | 5 | 0 | 9 | 2 | 0.025 | 1 |
| POTEC | 53098 | 5 | 3 | 6 | 0 | 0.029 | 1 |
| CNTNAP4 | 127976 | 4 | 0 | 9 | 0 | 0.03 | 1 |
| COL5A3 | 107975 | 2 | 1 | 8 | 3 | 0.031 | 1 |
| TPTE2 | 65858 | 3 | 1 | 8 | 1 | 0.034 | 1 |
| SPEN | 331749 | 7 | 2 | 15 | 2 | 0.035 | 1 |
