(primary solid tumor cohort)
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MAF used for this analysis:KIRP-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 29
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 29. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| NF2 | 20909 | 0 | 0 | 5 | 5 | 4.7e-93 | 8.9e-89 |
| KDM6A | 47174 | 0 | 0 | 6 | 6 | 1.1e-78 | 1.1e-74 |
| PCF11 | 48410 | 0 | 1 | 8 | 0 | 1e-51 | 6.4e-48 |
| IL32 | 6077 | 0 | 0 | 4 | 4 | 2.9e-41 | 1.4e-37 |
| STAG2 | 51191 | 0 | 1 | 5 | 5 | 1.9e-38 | 7e-35 |
| MET | 54796 | 0 | 0 | 8 | 0 | 2e-29 | 6.4e-26 |
| SETD2 | 76014 | 0 | 0 | 6 | 5 | 3.9e-26 | 1e-22 |
| FGFR3 | 17407 | 0 | 2 | 5 | 0 | 2.1e-23 | 5e-20 |
| FLJ46321 | 53766 | 0 | 1 | 7 | 3 | 2.5e-22 | 5.3e-19 |
| SRCAP | 85799 | 0 | 1 | 7 | 2 | 2.9e-14 | 5.5e-11 |
| SRRM2 | 74469 | 0 | 1 | 6 | 1 | 5e-11 | 8.2e-08 |
| ATP1A1 | 38419 | 0 | 0 | 5 | 0 | 5.2e-11 | 8.2e-08 |
| RERE | 40582 | 0 | 1 | 5 | 1 | 1.8e-10 | 2.7e-07 |
| QRICH2 | 48307 | 0 | 0 | 5 | 1 | 6.7e-09 | 9e-06 |
| SLC5A12 | 22454 | 0 | 1 | 4 | 0 | 7.5e-09 | 9.3e-06 |
| CDC27 | 30797 | 0 | 0 | 4 | 4 | 7.9e-09 | 9.3e-06 |
| LGI4 | 6592 | 0 | 0 | 4 | 0 | 2.2e-08 | 0.000025 |
| MLL2 | 128853 | 0 | 3 | 12 | 7 | 2.5e-08 | 0.000026 |
| LRBA | 120098 | 0 | 1 | 6 | 4 | 2.1e-06 | 0.002 |
| CMYA5 | 139668 | 0 | 0 | 6 | 1 | 3.2e-06 | 0.003 |
| MUC16 | 475757 | 0 | 0 | 10 | 1 | 7.7e-06 | 0.0068 |
| SFRS2IP | 55105 | 0 | 1 | 5 | 4 | 7.9e-06 | 0.0068 |
| SYNE1 | 337943 | 0 | 0 | 8 | 1 | 0.000022 | 0.018 |
| MLL3 | 166551 | 0 | 0 | 6 | 3 | 0.000025 | 0.019 |
| FAT1 | 167684 | 0 | 1 | 6 | 2 | 0.000026 | 0.02 |
| EP400 | 87653 | 0 | 0 | 5 | 1 | 0.000031 | 0.023 |
| BOD1L | 94554 | 0 | 0 | 5 | 0 | 0.000066 | 0.046 |
| MACF1 | 315386 | 0 | 2 | 9 | 0 | 0.000068 | 0.046 |
| POLQ | 98468 | 0 | 0 | 5 | 1 | 0.000097 | 0.063 |
| PARD6B | 13390 | 0 | 0 | 4 | 2 | 0.00016 | 0.1 |
| SVEP1 | 111137 | 0 | 0 | 5 | 2 | 0.00028 | 0.17 |
| FLG | 112270 | 0 | 1 | 5 | 1 | 0.0003 | 0.18 |
| HERC1 | 148320 | 0 | 0 | 5 | 1 | 0.0022 | 1 |
| SON | 82194 | 0 | 0 | 5 | 1 | 0.0045 | 1 |
| BAP1 | 23072 | 0 | 1 | 4 | 1 | 0.0062 | 1 |
