(primary solid tumor cohort)
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MAF used for this analysis:LGG-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 47
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 47. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| IDH1 | 27200 | 0 | 0 | 131 | 0 | 0 | 0 |
| ZNF860 | 340 | 0 | 0 | 6 | 0 | 0 | 0 |
| TP53 | 21420 | 0 | 2 | 116 | 19 | 1e-194 | 6.4e-191 |
| ATRX | 163540 | 0 | 2 | 82 | 65 | 2.8e-187 | 1.3e-183 |
| FUBP1 | 32640 | 0 | 2 | 19 | 16 | 7.6e-175 | 2.9e-171 |
| ARID1A | 98940 | 0 | 0 | 14 | 12 | 5.1e-109 | 1.6e-105 |
| CIC | 58310 | 0 | 0 | 40 | 18 | 3.4e-64 | 9.1e-61 |
| NOTCH1 | 88570 | 0 | 2 | 25 | 11 | 1.2e-33 | 2.9e-30 |
| MUC7 | 17340 | 0 | 0 | 8 | 0 | 2.8e-27 | 5.8e-24 |
| NF1 | 253810 | 0 | 1 | 21 | 15 | 8.4e-25 | 1.6e-21 |
| TCF12 | 41480 | 0 | 0 | 6 | 6 | 1.8e-24 | 3.1e-21 |
| PIK3R1 | 50150 | 0 | 1 | 13 | 7 | 4.8e-22 | 7.5e-19 |
| ARID2 | 103020 | 0 | 0 | 12 | 2 | 3.6e-18 | 5.3e-15 |
| IL32 | 10030 | 0 | 0 | 4 | 4 | 4.5e-16 | 6e-13 |
| AHNAK | 342210 | 0 | 4 | 17 | 0 | 2.6e-14 | 3.2e-11 |
| PTEN | 27370 | 0 | 0 | 8 | 3 | 4.5e-12 | 5.3e-09 |
| FERMT3 | 40290 | 0 | 0 | 5 | 0 | 3.3e-11 | 3.6e-08 |
| DOCK5 | 107610 | 0 | 0 | 8 | 1 | 1.3e-10 | 1.4e-07 |
| TPM1 | 22440 | 0 | 0 | 5 | 1 | 3.3e-10 | 3.3e-07 |
| NIPBL | 176630 | 0 | 0 | 10 | 7 | 2.7e-09 | 2.6e-06 |
| MLL3 | 274890 | 0 | 1 | 12 | 1 | 1.2e-08 | 0.000011 |
| HEATR5B | 116280 | 0 | 0 | 8 | 2 | 5.2e-08 | 0.000045 |
| DMXL1 | 184960 | 0 | 0 | 12 | 5 | 6.6e-08 | 0.000054 |
| ZNF318 | 120530 | 0 | 0 | 8 | 2 | 9.4e-08 | 0.000074 |
| MCCC2 | 31450 | 0 | 0 | 5 | 1 | 1.7e-07 | 0.00013 |
| C2orf71 | 63240 | 0 | 0 | 6 | 0 | 2.9e-07 | 0.00021 |
| SLTM | 59670 | 0 | 0 | 7 | 3 | 2.9e-07 | 0.00021 |
| IQGAP1 | 105230 | 0 | 1 | 9 | 1 | 3.1e-07 | 0.00021 |
| ZNF57 | 34510 | 0 | 0 | 7 | 0 | 9.9e-07 | 0.00064 |
| EGFR | 77690 | 0 | 0 | 10 | 1 | 1.3e-06 | 0.0008 |
| CELSR2 | 136340 | 0 | 2 | 9 | 0 | 4.4e-06 | 0.0027 |
| NLRP1 | 77690 | 0 | 1 | 6 | 1 | 4.8e-06 | 0.0028 |
| PIK3CA | 71570 | 0 | 0 | 15 | 3 | 7.8e-06 | 0.0045 |
| PTPRH | 60520 | 0 | 1 | 6 | 1 | 0.000013 | 0.0067 |
| PRKDC | 219810 | 0 | 2 | 9 | 2 | 0.000013 | 0.0067 |
