Lung Adenocarcinoma: Mutation Analysis (MutSig v2.0)<BR>(primary solid tumor cohort)

Lung Adenocarcinoma: Mutation Analysis (MutSig v2.0)
(primary solid tumor cohort)

Maintained by Dan DiCara (Broad Institute)

- Overview

+ Introduction

- Summary

MAF used for this analysis:LUAD-TP.final_analysis_set.maf
Significantly mutated genes (q ≤ 0.1): 215
Mutations seen in COSMIC: 515
Significantly mutated genes in COSMIC territory: 24
Genes with clustered mutations (≤ 3 aa apart): 383
Significantly mutated genesets: 16
Significantly mutated genesets: (excluding sig. mutated genes):0

Mutation Preprocessing

Read 229 MAFs of type "Broad"
Total number of mutations in input MAFs: 251233
After removing 79 mutations outside chr1-24: 251154
After removing 1211 blacklisted mutations: 249943
After removing 144408 noncoding mutations: 105535
After collapsing adjacent/redundant mutations: 94067

Mutation Filtering

Number of mutations before filtering: 94067
After removing 1293 mutations outside gene set: 92774
After removing 398 mutations outside category set: 92376

- Results

+ Breakdown of Mutations by Type

type	count
Frame_Shift_Del	1322
Frame_Shift_Ins	538
In_Frame_Del	165
In_Frame_Ins	20
Missense_Mutation	60570
Nonsense_Mutation	4838
Nonstop_Mutation	58
Silent	22873
Splice_Site	1859
Translation_Start_Site	133
Total	92376

+ Breakdown of Mutation Rates by Category Type

category	n	N	rate	rate_per_mb	relative_rate	exp_ns_s_ratio
*CpG->A	8886	379287204	0.000023	23	2.3	2.1
*Cp(A/C/T)->A	22047	3108508517	7.1e-06	7.1	0.7	5
C->(T/G)	18980	3487795721	5.4e-06	5.4	0.54	2.8
A->mut	10741	3354933814	3.2e-06	3.2	0.32	3.9
indel+null	8702	6842729535	1.3e-06	1.3	0.13	NaN
double_null	147	6842729535	2.1e-08	0.021	0.0021	NaN
Total	69503	6842729535	1e-05	10	1	3.5

+ Target Coverage for Each Individual

+ Distribution of Mutation Counts, Coverage, and Mutation Rates Across Samples

+ CoMut Plot

+ Significantly Mutated Genes

Column Descriptions:

N = number of sequenced bases in this gene across the individual set
n = number of (nonsilent) mutations in this gene across the individual set
npat = number of patients (individuals) with at least one nonsilent mutation
nsite = number of unique sites having a non-silent mutation
nsil = number of silent mutations in this gene across the individual set
n1 = number of nonsilent mutations of type: *CpG->A
n2 = number of nonsilent mutations of type: *Cp(A/C/T)->A
n3 = number of nonsilent mutations of type: C->(T/G)
n4 = number of nonsilent mutations of type: A->mut
n5 = number of nonsilent mutations of type: indel+null
n6 = number of nonsilent mutations of type: double_null
p_classic = p-value for the observed amount of nonsilent mutations being elevated in this gene
p_ns_s = p-value for the observed nonsilent/silent ratio being elevated in this gene
p_cons = p-value for enrichment of mutations at evolutionarily most-conserved sites in gene
p_joint = p-value for clustering + conservation
p = p-value (overall)
q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

Table 3. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 215. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

rank	gene	description	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_classic	p_ns_s	p_cons	p_joint	p	q
1	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	161903	60	60	6	0	0	47	10	3	0	0	1.9e-15	0.002	NaN	NaN	1.9e-15	1.9e-11
2	TP53	tumor protein p53	288082	126	117	104	2	8	22	31	18	47	0	2.8e-15	1.2e-10	NaN	NaN	2.8e-15	1.9e-11
3	KEAP1	kelch-like ECH-associated protein 1	418841	39	39	37	0	4	8	13	10	4	0	3.2e-15	0.000026	NaN	NaN	3.2e-15	1.9e-11
4	STK11	serine/threonine kinase 11	199230	21	20	20	0	0	4	2	4	11	0	6e-15	0.01	NaN	NaN	6e-15	2.7e-11
5	NAV3	neuron navigator 3	1659792	66	52	66	4	4	36	16	6	3	1	9.3e-14	0.0026	NaN	NaN	9.3e-14	3.4e-10
6	MAGEC1	melanoma antigen family C, 1	774020	39	33	38	2	2	14	13	7	3	0	9.2e-13	0.0051	NaN	NaN	9.2e-13	2.8e-09
7	CDH10	cadherin 10, type 2 (T2-cadherin)	552119	51	40	51	8	4	27	12	1	7	0	2e-11	0.27	NaN	NaN	2e-11	5.2e-08
8	TMTC1	transmembrane and tetratricopeptide repeat containing 1	543417	32	26	30	3	3	17	7	3	2	0	4.5e-11	0.055	NaN	NaN	4.5e-11	1e-07
9	MUC7	mucin 7, secreted	261518	19	17	19	1	0	8	3	5	3	0	2.7e-10	0.091	NaN	NaN	2.7e-10	5.4e-07
10	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	482503	20	20	20	0	0	4	4	8	4	0	1.3e-09	0.015	NaN	NaN	1.3e-09	2.3e-06
11	OR2L3	olfactory receptor, family 2, subfamily L, member 3	215947	16	15	16	2	1	9	2	4	0	0	1.7e-09	0.19	NaN	NaN	1.7e-09	2.9e-06
12	RIMS2	regulating synaptic membrane exocytosis 2	994318	45	39	45	4	4	16	10	8	7	0	2.7e-09	0.051	NaN	NaN	2.7e-09	4.2e-06
13	REG3A	regenerating islet-derived 3 alpha	125492	15	14	14	2	0	4	7	2	2	0	4e-09	0.25	NaN	NaN	4e-09	5.5e-06
14	CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	226023	14	14	14	1	0	1	4	4	5	0	4.9e-09	0.26	NaN	NaN	4.9e-09	6.3e-06
15	EPHA6	EPH receptor A6	755242	33	30	33	4	3	17	7	3	3	0	7.2e-09	0.17	NaN	NaN	7.2e-09	8.6e-06
16	CNBD1	cyclic nucleotide binding domain containing 1	238160	14	14	14	1	0	5	3	4	2	0	7.7e-09	0.32	NaN	NaN	7.7e-09	8.7e-06
17	OR2T4	olfactory receptor, family 2, subfamily T, member 4	240679	18	17	18	2	1	7	8	2	0	0	9.8e-09	0.071	NaN	NaN	9.8e-09	1e-05
18	CD5L	CD5 molecule-like	244572	15	15	15	1	3	3	0	5	4	0	1.2e-08	0.1	NaN	NaN	1.2e-08	0.000012
19	OR4C16	olfactory receptor, family 4, subfamily C, member 16	214115	15	14	14	0	0	9	2	3	1	0	1.5e-08	0.035	NaN	NaN	1.5e-08	0.000014
20	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	314646	18	17	18	1	3	6	4	4	1	0	1.6e-08	0.038	NaN	NaN	1.6e-08	0.000014
21	ZNF676	zinc finger protein 676	407391	21	20	20	2	0	9	9	0	3	0	1.8e-08	0.27	NaN	NaN	1.8e-08	0.000016
22	BAGE2	B melanoma antigen family, member 2	79234	9	9	9	0	0	4	2	1	2	0	2e-08	0.12	NaN	NaN	2e-08	0.000017
23	OR4A5	olfactory receptor, family 4, subfamily A, member 5	218008	13	12	13	0	1	4	3	4	1	0	3.5e-08	0.035	NaN	NaN	3.5e-08	0.000028
24	TRIM58	tripartite motif-containing 58	254648	15	15	15	2	1	3	3	5	3	0	5.1e-08	0.19	NaN	NaN	5.1e-08	0.000038
25	REG1B	regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)	119309	14	13	14	2	1	7	1	3	2	0	1.4e-07	0.39	NaN	NaN	1.4e-07	0.0001
26	ZNF804A	zinc finger protein 804A	834934	44	38	44	5	0	26	8	4	6	0	1.6e-07	0.31	NaN	NaN	1.6e-07	0.00011
27	LRRIQ3	leucine-rich repeats and IQ motif containing 3	435787	17	15	16	1	1	3	3	5	5	0	1.7e-07	0.26	NaN	NaN	1.7e-07	0.00011
28	C18orf34	chromosome 18 open reading frame 34	606392	23	21	23	2	0	11	4	6	2	0	2.6e-07	0.27	NaN	NaN	2.6e-07	0.00016
29	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	275029	15	15	15	2	0	4	4	5	2	0	2.8e-07	0.37	NaN	NaN	2.8e-07	0.00018
30	OR2L8	olfactory receptor, family 2, subfamily L, member 8	215947	15	13	13	2	1	8	3	2	1	0	3e-07	0.23	NaN	NaN	3e-07	0.00018
31	TBX22	T-box 22	353118	16	16	16	1	2	9	2	2	1	0	4.6e-07	0.15	NaN	NaN	4.6e-07	0.00027
32	BRAF	v-raf murine sarcoma viral oncogene homolog B1	510899	17	17	12	1	1	7	2	5	2	0	5.6e-07	0.096	NaN	NaN	5.6e-07	0.00032
33	OR5W2	olfactory receptor, family 5, subfamily W, member 2	214115	12	11	12	1	0	3	6	2	1	0	8.5e-07	0.13	NaN	NaN	8.5e-07	0.00047
34	OR8H2	olfactory receptor, family 8, subfamily H, member 2	215489	17	15	17	3	0	9	5	1	2	0	1.1e-06	0.24	NaN	NaN	1.1e-06	0.00056
35	OR5D14	olfactory receptor, family 5, subfamily D, member 14	217092	20	19	19	3	0	9	5	5	1	0	1.5e-06	0.17	NaN	NaN	1.5e-06	0.00076

+ COSMIC analyses

In this analysis, COSMIC is used as a filter to increase power by restricting the territory of each gene. Cosmic version: v48.

Table 4. Get Full Table Significantly mutated genes (COSMIC territory only). To access the database please go to: COSMIC. Number of significant genes found: 24. Number of genes displayed: 10

rank	gene	description	n	cos	n_cos	N_cos	cos_ev	p	q
1	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	60	52	60	11908	797017	0	0
2	LRP1B	low density lipoprotein-related protein 1B (deleted in tumors)	148	18	8	4122	8	0	0
3	TP53	tumor protein p53	126	356	121	81524	18205	0	0
4	BRAF	v-raf murine sarcoma viral oncogene homolog B1	17	89	12	20381	28944	0	0
5	STK11	serine/threonine kinase 11	21	130	14	29770	27	0	0
6	EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	33	293	29	67097	10294	0	0
7	CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	14	332	14	76028	259	0	0
8	MET	met proto-oncogene (hepatocyte growth factor receptor)	12	34	6	7786	64	3.2e-10	1.8e-07
9	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	11	220	9	50380	3946	4.2e-09	2.1e-06
10	NF1	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)	29	285	9	65265	13	3.8e-08	0.000017

Note:

n - number of (nonsilent) mutations in this gene across the individual set.

cos = number of unique mutated sites in this gene in COSMIC

n_cos = overlap between n and cos.

N_cos = number of individuals times cos.

cos_ev = total evidence: number of reports in COSMIC for mutations seen in this gene.

p = p-value for seeing the observed amount of overlap in this gene)

q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

+ Clustered Mutations

num	gene	desc	n	nmuts0	nmuts3	nmuts12	npairs0	npairs3	npairs12
6685	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	60	1382	1488	1488	1382	1488	1488
13082	TP53	tumor protein p53	126	53	200	636	53	200	636
3860	EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	33	39	60	60	39	60	60
9555	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	11	6	10	11	6	10	11
8459	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	4	6	6	6	6	6	6
13286	TSHZ3	teashirt zinc finger homeobox 3	39	5	14	29	5	14	29
1223	BRAF	v-raf murine sarcoma viral oncogene homolog B1	17	5	9	13	5	9	13
6423	KEAP1	kelch-like ECH-associated protein 1	39	4	17	44	4	17	44
14403	ZNF536	zinc finger protein 536	54	4	11	28	4	11	28
2387	CDH18	cadherin 18, type 2	31	4	11	23	4	11	23

+ Geneset Analyses

Table 6. Get Full Table A Ranked List of Significantly Mutated Genesets. (Source: MSigDB GSEA Cannonical Pathway Set).Number of significant genesets found: 16. Number of genesets displayed: 10

rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	p_ns_s	p	q
1	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(8), ATM(22), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1A(1), E2F1(3), GADD45A(1), MDM2(2), PCNA(1), RB1(13), TP53(126)	6266585	190	141	167	16	16	37	42	29	66	1.9e-06	<1.00e-15	<1.78e-13
2	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(3), MAX(3), SP1(1), SP3(4), TP53(126), WT1(8)	2427858	145	120	123	10	9	29	35	21	51	1.2e-06	<1.00e-15	<1.78e-13
3	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(3), DNAJC3(3), MAP3K14(1), NFKB1(3), NFKBIA(1), TP53(126)	3372941	137	119	115	9	9	23	36	18	51	2.2e-06	1.22e-15	1.78e-13
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1A(1), CDKN1B(3), CDKN2A(14), E2F1(3), MDM2(2), NXT1(1), PRB1(3), TP53(126)	2958909	162	124	140	8	15	29	38	24	56	1.1e-09	1.33e-15	1.78e-13
5	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CDK2(4), CDK4(2), CHEK1(6), MYT1(6), RB1(13), TP53(126), WEE1(3)	6070332	190	138	167	13	15	37	43	29	66	1.6e-07	1.44e-15	1.78e-13
6	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(22), ATR(17), CDC25C(3), CHEK1(6), CHEK2(2), TP53(126)	5517526	176	134	153	7	10	35	48	28	55	1e-08	2.66e-15	2.54e-13
7	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(14), E2F1(3), MDM2(2), PIK3CA(11), PIK3R1(3), POLR1A(8), POLR1B(10), POLR1D(2), RB1(13), TBX2(1), TP53(126), TWIST1(1)	7038773	196	131	170	15	16	33	53	29	65	2.8e-08	2.89e-15	2.54e-13
8	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(4), IFNGR1(3), IFNGR2(3), IKBKB(3), JAK2(4), LIN7A(2), NFKB1(3), NFKBIA(1), RB1(13), TNFRSF1B(1), TP53(126), USH1C(4), WT1(8)	6332308	175	131	153	16	15	35	41	21	63	1.8e-06	4.00e-15	3.08e-13
9	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(20), ATM(22), BAX(1), CDKN1A(1), CPB2(4), CSNK1A1(1), CSNK1D(2), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NQO1(3), TP53(126)	7172280	189	136	165	18	17	40	45	27	60	0.000012	6.44e-15	4.41e-13
10	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), DAXX(6), HRAS(1), PAX3(6), PML(7), RARA(3), RB1(13), SIRT1(1), SP100(9), TNFRSF1B(1), TP53(126)	6622222	177	129	155	15	14	30	47	25	61	3.8e-07	9.44e-15	5.47e-13

Table 7. Get Full Table A Ranked List of Significantly Mutated Genesets (Excluding Significantly Mutated Genes). Number of significant genesets found: 0. Number of genesets displayed: 10

rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(4), IL12A(3), IL2(5)	1033019	14	12	13	1	2	7	2	2	1	0	0.15	0.23	1
2	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(4), COQ5(5), COQ6(3), COQ7(1), NDUFA12(2), NDUFA13(4), NDUFB11(1)	1380412	20	14	20	2	5	5	5	1	4	0	0.082	0.31	1
3	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(7), SNAP25(4), STX1A(3)	1118665	16	13	16	3	5	3	5	1	2	0	0.2	0.34	1
4	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(3), CDK2(4), CDKN1B(3), CUL1(6), E2F1(3), NEDD8(2), SKP2(4), TFDP1(3), UBE2M(1)	2352746	29	22	29	4	5	6	10	6	2	0	0.082	0.35	1
5	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(9), CYP2C9(3)	690893	12	11	12	3	2	3	3	2	2	0	0.54	0.39	1
6	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NFS1(4), PHPT1(1), TPK1(5)	2218323	25	20	25	3	1	9	6	7	1	1	0.15	0.54	1
7	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), FBXW7(4), TFDP1(3)	2268932	24	18	24	2	5	6	8	5	0	0	0.035	0.59	1
8	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(6)	566088	6	5	6	0	0	3	2	1	0	0	0.24	0.6	1
9	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(4), ALDOC(1), TPI1(6)	1340337	13	10	13	0	0	5	4	2	2	0	0.043	0.72	1
10	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(8), BCMO1(4)	1334612	15	13	15	3	2	4	5	1	3	0	0.33	0.75	1

+ Methods & Data

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