Lung Squamous Cell Carcinoma: Mutation Analysis (MutSig vS2N)
(primary solid tumor cohort)
Maintained by Dan DiCara (Broad Institute)
- Overview
+ Introduction
- Summary
- Results
- Significantly Mutated Genes

Column Descriptions:

  • N = number of sequenced bases in this gene across the individual set

  • nnon = number of (nonsilent) mutations in this gene across the individual set

  • nnull = number of (nonsilent) null mutations in this gene across the individual set

  • nflank = number of noncoding mutations from this gene's flanking region, across the individual set

  • nsil = number of silent mutations in this gene across the individual set

  • p = p-value (overall)

  • q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

Table 1.  Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 8. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

gene N nflank nsil nnon nnull p q
TP53 22428 0 5 146 47 4.8e-145 9.1e-141
CDKN2A 10020 3 1 26 12 9e-62 8.5e-58
PIK3CA 74998 1 1 29 0 4.2e-29 2.6e-25
HLA-A 19194 0 0 7 6 7.4e-16 3.5e-12
KEAP1 32842 0 0 23 2 1.8e-13 6.9e-10
PTEN 28478 1 0 16 8 1.6e-12 5e-09
NFE2L2 38270 1 0 28 1 3e-12 8e-09
MLL2 221958 3 6 40 18 1.1e-11 2.7e-08
PRR23B 9552 0 2 9 0 0.000087 0.18
FSCB 40910 0 2 19 1 0.00012 0.23
SCN1A 141098 2 9 32 3 0.00013 0.23
WHSC1L1 93628 2 1 16 2 0.00025 0.39
COL19A1 56664 6 4 19 2 0.00027 0.39
AHNAK 358404 0 8 25 1 0.00034 0.45
ASCL4 3234 0 0 6 2 0.00036 0.45
MAGEB2 15514 0 1 9 0 0.00044 0.51
OR2G6 20648 0 3 15 0 0.00047 0.52
ZNF208 84566 1 6 27 1 0.00059 0.57
TRIOBP 96658 2 1 20 1 0.00059 0.57
AKAP13 169872 3 4 19 0 0.0006 0.57
TAS2R60 21004 0 0 8 0 0.00071 0.61
SPHKAP 103032 2 3 34 1 0.00072 0.61
TPTE 40970 10 2 30 5 0.00087 0.69
CPS1 99740 10 3 26 2 0.00091 0.69
REG3A 10858 2 2 13 1 0.00095 0.69
CYP11B1 29548 1 0 15 0 0.00096 0.69
MYPN 78468 1 4 15 0 0.0011 0.76
MYH2 131572 2 6 33 3 0.0013 0.82
FAM47C 50224 0 5 21 1 0.0013 0.82
DNAH6 28928 1 1 5 1 0.0014 0.87
EBF1 33494 1 1 8 1 0.0016 0.96
CD109 99058 3 1 8 0 0.0019 1
ZIC1 23436 0 4 20 2 0.0019 1
PKHD1L1 250712 6 11 42 2 0.002 1
OR4M2 22072 0 3 15 1 0.0027 1
+ Methods & Data
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