(primary solid tumor cohort)
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MAF used for this analysis:PRAD-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 8
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 8. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| NKX3-1 | 4482 | 0 | 0 | 5 | 1 | 7.7e-52 | 1.5e-47 |
| ZMYM3 | 29005 | 0 | 0 | 5 | 3 | 1.7e-18 | 1.6e-14 |
| TP53 | 10458 | 0 | 0 | 5 | 1 | 3.7e-12 | 2.3e-08 |
| MLL3 | 134697 | 2 | 0 | 10 | 7 | 2.4e-11 | 1.1e-07 |
| SPOP | 11452 | 2 | 0 | 4 | 0 | 3.8e-07 | 0.0014 |
| MUC4 | 53171 | 0 | 2 | 5 | 0 | 1.1e-06 | 0.0034 |
| ATM | 99612 | 0 | 0 | 5 | 0 | 6.7e-06 | 0.018 |
| CNTNAP5 | 34965 | 0 | 0 | 5 | 1 | 0.000039 | 0.093 |
| TTN | 1059218 | 1 | 4 | 18 | 4 | 0.002 | 1 |
| YBX1 | 6723 | 0 | 0 | 4 | 0 | 0.0022 | 1 |
| AHNAK2 | 141681 | 0 | 2 | 7 | 0 | 0.0075 | 1 |
| FRG1 | 8715 | 1 | 0 | 4 | 1 | 0.0084 | 1 |
| PRR21 | 5229 | 0 | 0 | 4 | 0 | 0.099 | 1 |
| LRP1B | 143560 | 2 | 1 | 5 | 1 | 0.19 | 1 |
| MUC16 | 382810 | 1 | 4 | 9 | 0 | 0.21 | 1 |
| FCGBP | 80613 | 0 | 1 | 5 | 0 | 0.25 | 1 |
| LPHN3 | 35599 | 0 | 1 | 4 | 0 | 0.35 | 1 |
| MUC17 | 112710 | 0 | 1 | 5 | 0 | 0.36 | 1 |
| INADL | 52620 | 3 | 0 | 4 | 1 | 0.39 | 1 |
| RP1 | 67724 | 0 | 0 | 4 | 1 | 0.39 | 1 |
| FAT1 | 134152 | 0 | 1 | 5 | 0 | 0.42 | 1 |
| SYNE1 | 272080 | 6 | 1 | 5 | 0 | 0.47 | 1 |
| HSPG2 | 87788 | 0 | 1 | 4 | 0 | 0.53 | 1 |
| GRID2 | 30955 | 0 | 1 | 4 | 0 | 0.55 | 1 |
| ASH1L | 87644 | 1 | 0 | 4 | 2 | 0.58 | 1 |
| DMXL2 | 90047 | 1 | 0 | 4 | 3 | 0.58 | 1 |
| SETD5 | 35360 | 0 | 1 | 4 | 0 | 0.59 | 1 |
| CSMD3 | 110953 | 2 | 1 | 4 | 2 | 0.81 | 1 |
| FZD2 | 14278 | 0 | 4 | 4 | 1 | 0.84 | 1 |
| FAT4 | 142381 | 0 | 3 | 4 | 1 | 0.85 | 1 |
| CROCC | 24473 | 7 | 1 | 4 | 0 | 0.92 | 1 |
| AGT | 13114 | 0 | 0 | 3 | 0 | 1 | 1 |
| AIM2 | 11618 | 0 | 0 | 3 | 1 | 1 | 1 |
| ANK2 | 110058 | 2 | 0 | 3 | 0 | 1 | 1 |
| ANO4 | 30376 | 0 | 0 | 3 | 0 | 1 | 1 |
