Skin Cutaneous Melanoma: Mutation Analysis (MutSig vS2N)
(metastatic tumor cohort)
Maintained by Dan DiCara (Broad Institute)
- Overview
+ Introduction
- Summary
- Results
- Significantly Mutated Genes

Column Descriptions:

  • N = number of sequenced bases in this gene across the individual set

  • nnon = number of (nonsilent) mutations in this gene across the individual set

  • nnull = number of (nonsilent) null mutations in this gene across the individual set

  • nflank = number of noncoding mutations from this gene's flanking region, across the individual set

  • nsil = number of silent mutations in this gene across the individual set

  • p = p-value (overall)

  • q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

Table 1.  Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 231. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

gene N nflank nsil nnon nnull p q
NRAS 16425 0 1 65 0 2.7e-282 5.1e-278
BRAF 58725 0 2 120 0 1.7e-224 1.6e-220
CDKN2A 13500 0 1 31 21 1.4e-75 9e-72
RTL1 11925 0 3 13 0 2.4e-36 1.1e-32
EYS 50625 0 1 10 0 7.8e-29 2.9e-25
DNAH6 36225 0 1 16 1 1.5e-28 4.8e-25
SPRR3 11250 0 3 12 1 2.3e-23 6.3e-20
SMR3A 6300 0 2 8 0 4e-21 9.4e-18
CCNE2 40275 0 2 12 1 5.6e-20 1.2e-16
NOTCH2 174150 0 9 34 2 4.8e-18 9.1e-15
PPT2 23625 0 2 8 0 2.6e-17 4.4e-14
TAF1A 40950 0 0 14 0 8.2e-17 1.3e-13
LIPF 35775 0 5 14 0 1.3e-16 1.9e-13
ADAM30 65250 0 11 34 3 1.9e-16 2.5e-13
NAP1L4 32625 0 0 13 2 2.6e-16 3.3e-13
DEFB115 7650 0 2 7 1 4.7e-16 5.6e-13
PTEN 36225 0 0 18 11 1.4e-15 1.5e-12
INTS8 83025 0 1 20 2 1.5e-15 1.5e-12
TBC1D3 9675 2 0 7 0 3.8e-14 3.8e-11
TP53 28350 0 1 37 14 7.7e-14 7.3e-11
DISP1 124650 0 9 41 5 1.1e-12 9.8e-10
STK31 91350 0 4 36 2 1.2e-12 1e-09
PRC1 52425 0 2 14 1 1.2e-11 9.5e-09
CDC123 30825 0 0 7 2 1.5e-11 1.2e-08
IVL 19575 0 4 11 0 1.9e-11 1.4e-08
DPY19L4 67275 0 2 18 4 2.2e-11 1.6e-08
CLCC1 49725 0 1 13 2 3.7e-11 2.6e-08
ZNF860 450 0 0 4 0 1.1e-10 7.3e-08
IDH1 36000 0 1 11 0 1.3e-10 8.7e-08
RPTN 58275 0 4 47 0 1.7e-10 1.1e-07
PPP6C 25875 0 2 18 4 8.2e-10 4.9e-07
CECR6 9450 0 1 6 0 8.4e-10 4.9e-07
THADA 141525 0 5 28 4 1.4e-09 7.8e-07
PIK3CB 92925 0 3 21 4 1.6e-09 8.8e-07
ADAM21 58500 0 3 19 1 1.6e-09 8.8e-07
+ Methods & Data