(primary solid tumor cohort)
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MAF used for this analysis:STAD-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 11
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 11. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| TP53 | 14616 | 1 | 1 | 57 | 19 | 1.1e-59 | 2.1e-55 |
| KRAS | 12004 | 0 | 0 | 14 | 0 | 9.3e-56 | 8.7e-52 |
| CBWD1 | 13232 | 3 | 0 | 15 | 14 | 8.9e-42 | 5.6e-38 |
| RPL22 | 5800 | 1 | 0 | 9 | 9 | 3e-36 | 1.4e-32 |
| ARID1A | 67512 | 5 | 1 | 26 | 17 | 1.4e-16 | 5.3e-13 |
| RNF43 | 23260 | 4 | 2 | 14 | 9 | 9.5e-12 | 3e-08 |
| PIK3CA | 48948 | 10 | 2 | 32 | 1 | 1.6e-11 | 4.3e-08 |
| PHF2 | 33056 | 6 | 4 | 13 | 9 | 4.3e-10 | 1e-06 |
| PGM5 | 18160 | 4 | 0 | 19 | 2 | 6.7e-10 | 1.4e-06 |
| ACVR2A | 22036 | 7 | 0 | 14 | 10 | 1.3e-09 | 2.4e-06 |
| MLL2 | 143772 | 3 | 6 | 29 | 10 | 0.000011 | 0.02 |
| HLA-B | 11080 | 6 | 0 | 10 | 5 | 0.000091 | 0.14 |
| RHOA | 11136 | 5 | 0 | 8 | 0 | 0.00016 | 0.22 |
| UPF3A | 13976 | 4 | 1 | 6 | 5 | 0.00017 | 0.22 |
| ERBB3 | 51192 | 5 | 3 | 16 | 0 | 0.00036 | 0.45 |
| HNF1A | 19780 | 1 | 0 | 6 | 5 | 0.00071 | 0.84 |
| IRF2 | 15024 | 2 | 1 | 11 | 3 | 0.00076 | 0.84 |
| OR8H3 | 14672 | 0 | 1 | 10 | 0 | 0.0011 | 1 |
| DRD3 | 15660 | 3 | 2 | 6 | 0 | 0.0011 | 1 |
| NCOA2 | 55744 | 14 | 2 | 12 | 1 | 0.0015 | 1 |
| LRRN3 | 32132 | 2 | 3 | 11 | 2 | 0.0016 | 1 |
| BMPR2 | 42456 | 6 | 0 | 12 | 6 | 0.0016 | 1 |
| MLL4 | 56872 | 2 | 3 | 17 | 7 | 0.0017 | 1 |
| DOCK3 | 76004 | 18 | 5 | 23 | 9 | 0.0017 | 1 |
| BCOR | 56996 | 9 | 2 | 14 | 8 | 0.0019 | 1 |
| MAP2K7 | 12444 | 4 | 0 | 12 | 1 | 0.0026 | 1 |
| SAFB2 | 25576 | 4 | 2 | 6 | 5 | 0.003 | 1 |
| MUC17 | 157408 | 3 | 11 | 24 | 0 | 0.0032 | 1 |
| SPERT | 12352 | 0 | 2 | 7 | 2 | 0.0034 | 1 |
| CRYGC | 6960 | 0 | 0 | 5 | 0 | 0.0044 | 1 |
| TPTE | 26736 | 15 | 3 | 15 | 1 | 0.0051 | 1 |
| TLR4 | 37584 | 0 | 2 | 11 | 0 | 0.0064 | 1 |
| XRN2 | 38684 | 11 | 0 | 10 | 1 | 0.0074 | 1 |
| RP1 | 94536 | 4 | 7 | 16 | 1 | 0.0078 | 1 |
| CNGA4 | 22736 | 0 | 2 | 9 | 0 | 0.008 | 1 |
