(primary solid tumor cohort)
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MAF used for this analysis:THCA-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 29
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 29. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| BRAF | 84303 | 0 | 1 | 183 | 0 | 0 | 0 |
| NRAS | 23790 | 0 | 0 | 26 | 0 | 0 | 0 |
| HRAS | 22597 | 0 | 0 | 12 | 0 | 0 | 0 |
| EMG1 | 30474 | 0 | 0 | 6 | 6 | 0 | 0 |
| TG | 318775 | 0 | 3 | 16 | 10 | 6.8e-126 | 2.6e-122 |
| PRB2 | 22808 | 0 | 1 | 6 | 3 | 1.9e-66 | 5.9e-63 |
| EIF1AX | 18088 | 0 | 0 | 6 | 1 | 3.6e-62 | 9.6e-59 |
| PTTG1IP | 17442 | 0 | 0 | 4 | 4 | 1.4e-48 | 3.2e-45 |
| MUC7 | 33157 | 0 | 1 | 5 | 1 | 1.1e-41 | 2.3e-38 |
| ZNF845 | 77648 | 0 | 0 | 6 | 0 | 1e-34 | 1.9e-31 |
| RPTN | 83868 | 0 | 0 | 8 | 7 | 5.6e-31 | 9.5e-28 |
| PPM1D | 56848 | 0 | 0 | 5 | 4 | 1.3e-24 | 2e-21 |
| TROAP | 68476 | 0 | 0 | 5 | 0 | 1.4e-20 | 2.1e-17 |
| PRG4 | 148455 | 0 | 1 | 7 | 3 | 2.7e-17 | 3.6e-14 |
| FAM47C | 90354 | 0 | 3 | 5 | 0 | 9.2e-16 | 1.1e-12 |
| ARID1B | 175824 | 0 | 0 | 6 | 2 | 9.7e-16 | 1.1e-12 |
| ZNF799 | 73433 | 0 | 1 | 5 | 0 | 1.2e-15 | 1.3e-12 |
| DNMT3A | 91620 | 0 | 0 | 5 | 4 | 1.5e-15 | 1.6e-12 |
| GPR44 | 14759 | 0 | 0 | 4 | 4 | 2.6e-15 | 2.6e-12 |
| R3HDM2 | 59828 | 0 | 0 | 4 | 4 | 9.8e-15 | 9.2e-12 |
| CCDC15 | 86358 | 0 | 1 | 5 | 0 | 3.3e-13 | 3e-10 |
| ZNF780A | 77369 | 0 | 1 | 4 | 0 | 4.1e-11 | 3.5e-08 |
| MLL3 | 523557 | 0 | 0 | 8 | 4 | 4.7e-11 | 3.9e-08 |
| ZFHX3 | 379960 | 0 | 2 | 10 | 4 | 5e-11 | 3.9e-08 |
| DICER1 | 232461 | 0 | 0 | 5 | 2 | 1.4e-06 | 0.0011 |
| COL5A3 | 116788 | 0 | 0 | 6 | 2 | 1.9e-06 | 0.0014 |
| ZNF208 | 160969 | 1 | 0 | 4 | 0 | 4.4e-06 | 0.003 |
| CD209 | 45543 | 0 | 1 | 4 | 0 | 0.00014 | 0.093 |
| CHD2 | 219627 | 0 | 0 | 4 | 4 | 0.00015 | 0.098 |
| ANK1 | 210075 | 0 | 0 | 4 | 0 | 0.00019 | 0.12 |
| ATM | 388272 | 0 | 0 | 5 | 2 | 0.00032 | 0.19 |
| PKHD1L1 | 454474 | 0 | 0 | 5 | 4 | 0.001 | 0.6 |
| ACRC | 65819 | 0 | 0 | 4 | 0 | 0.0021 | 1 |
| DNAH2 | 521223 | 0 | 0 | 5 | 0 | 0.0025 | 1 |
| PRDM9 | 98838 | 0 | 3 | 6 | 1 | 0.0026 | 1 |
