Correlation between gene mutation status and molecular subtypes
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.

Summary

Testing the association between mutation status of 209 genes and 10 molecular subtypes across 224 patients, 38 significant findings detected with P value < 0.05 and Q value < 0.25.

  • FBXW7 mutation correlated to 'CN_CNMF'.

  • BRAF mutation correlated to 'MRNA_CNMF',  'MRNA_CHIERARCHICAL',  'CN_CNMF',  'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.

  • KRAS mutation correlated to 'MRNASEQ_CNMF' and 'MRNASEQ_CHIERARCHICAL'.

  • TP53 mutation correlated to 'CN_CNMF'.

  • FAT4 mutation correlated to 'CN_CNMF'.

  • CDH2 mutation correlated to 'MRNA_CNMF',  'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.

  • FLG mutation correlated to 'MRNA_CNMF' and 'MRNASEQ_CHIERARCHICAL'.

  • DNAH5 mutation correlated to 'CN_CNMF',  'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.

  • SDK1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • TMEM132D mutation correlated to 'MRNA_CNMF'.

  • LRRN3 mutation correlated to 'MRNASEQ_CNMF'.

  • GUCY1A3 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • OR51V1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • ZC3H13 mutation correlated to 'CN_CNMF' and 'MRNASEQ_CHIERARCHICAL'.

  • CSMD3 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • DCAF4L2 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • DOCK2 mutation correlated to 'MRNA_CNMF',  'CN_CNMF',  'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.

  • RIMS1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.

  • CDH10 mutation correlated to 'MRNA_CNMF',  'CN_CNMF', and 'MRNASEQ_CHIERARCHICAL'.

  • SYNE1 mutation correlated to 'MRNA_CNMF',  'MRNA_CHIERARCHICAL', and 'CN_CNMF'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 209 genes and 10 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, 38 significant findings detected.

Clinical
Features 		MRNA
CNMF 		MRNA
CHIERARCHICAL 		CN
CNMF 		METHLYATION
CNMF 		RPPA
CNMF 		RPPA
CHIERARCHICAL 		MRNASEQ
CNMF 		MRNASEQ
CHIERARCHICAL 		MIRSEQ
CNMF 		MIRSEQ
CHIERARCHICAL
nMutated (%) nWild-Type Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test
BRAF 22 (10%) 202 1.13e-06
(0.00205) 		1.26e-07
(0.000228) 		4.17e-05
(0.0749) 		0.875
(1.00) 		0.227
(1.00) 		3.49e-08
(6.34e-05) 		1.92e-10
(3.49e-07) 		0.6
(1.00) 		1
(1.00)
DOCK2 21 (9%) 203 0.000122
(0.217) 		0.00397
(1.00) 		0.000138
(0.245) 		0.0958
(1.00) 		0.779
(1.00) 		1.35e-05
(0.0244) 		7.91e-07
(0.00143) 		1
(1.00) 		0.101
(1.00)
CDH2 16 (7%) 208 3.19e-05
(0.0573) 		0.00563
(1.00) 		0.00381
(1.00) 		0.0336
(1.00) 		0.817
(1.00) 		5.18e-05
(0.093) 		1.1e-05
(0.0198) 		0.41
(1.00) 		0.683
(1.00)
DNAH5 34 (15%) 190 0.000387
(0.683) 		0.00585
(1.00) 		0.00013
(0.231) 		0.62
(1.00) 		0.301
(1.00) 		7.52e-05
(0.135) 		1.52e-06
(0.00275) 		1
(1.00) 		0.238
(1.00)
CDH10 14 (6%) 210 4.46e-05
(0.0801) 		0.00333
(1.00) 		0.000131
(0.233) 		0.336
(1.00) 		0.605
(1.00) 		0.00456
(1.00) 		2.68e-05
(0.0483) 		1
(1.00) 		0.257
(1.00)
SYNE1 47 (21%) 177 2.86e-05
(0.0514) 		2.56e-05
(0.046) 		1.63e-06
(0.00295) 		1
(1.00) 		0.641
(1.00) 		0.419
(1.00) 		0.0204
(1.00) 		0.000383
(0.677) 		0.367
(1.00) 		0.0326
(1.00)
KRAS 96 (43%) 128 0.000775
(1.00) 		0.00193
(1.00) 		0.485
(1.00) 		0.257
(1.00) 		0.742
(1.00) 		0.946
(1.00) 		1.94e-07
(0.000351) 		3.02e-07
(0.000547) 		0.0688
(1.00) 		0.735
(1.00)
FLG 32 (14%) 192 2.36e-06
(0.00426) 		0.00102
(1.00) 		0.00376
(1.00) 		0.0122
(1.00) 		0.813
(1.00) 		0.00123
(1.00) 		4.08e-05
(0.0734) 		1
(1.00) 		0.74
(1.00)
ZC3H13 21 (9%) 203 0.000395
(0.697) 		0.000571
(1.00) 		8.41e-05
(0.15) 		0.345
(1.00) 		0.676
(1.00) 		0.000883
(1.00) 		6.7e-05
(0.12) 		1
(1.00) 		0.306
(1.00)
FBXW7 38 (17%) 186 0.0186
(1.00) 		0.0302
(1.00) 		0.000122
(0.217) 		0.0191
(1.00) 		0.126
(1.00) 		0.000223
(0.397) 		0.000368
(0.651) 		0.356
(1.00) 		0.118
(1.00)
TP53 120 (54%) 104 0.00037
(0.654) 		0.00159
(1.00) 		7.28e-11
(1.32e-07) 		0.887
(1.00) 		0.658
(1.00) 		0.00978
(1.00) 		0.00162
(1.00) 		0.0252
(1.00) 		0.134
(1.00)
FAT4 39 (17%) 185 0.0134
(1.00) 		0.08
(1.00) 		6.63e-05
(0.119) 		0.597
(1.00) 		0.0868
(1.00) 		0.0448
(1.00) 		0.00381
(1.00) 		0.635
(1.00) 		0.683
(1.00)
SDK1 27 (12%) 197 0.00909
(1.00) 		0.00366
(1.00) 		0.24
(1.00) 		0.764
(1.00) 		0.941
(1.00) 		0.00143
(1.00) 		0.000102
(0.182) 		0.6
(1.00) 		1
(1.00)
TMEM132D 19 (8%) 205 2.85e-05
(0.0512) 		0.00157
(1.00) 		0.00293
(1.00) 		0.0366
(1.00) 		0.913
(1.00) 		0.00222
(1.00) 		0.00162
(1.00) 		1
(1.00) 		1
(1.00)
LRRN3 10 (4%) 214 0.00243
(1.00) 		0.123
(1.00) 		0.446
(1.00) 		0.387
(1.00) 		0.528
(1.00) 		9.57e-05
(0.171) 		0.0318
(1.00) 		0.274
(1.00) 		0.502
(1.00)
GUCY1A3 12 (5%) 212 0.38
(1.00) 		0.172
(1.00) 		0.0311
(1.00) 		0.825
(1.00) 		1
(1.00) 		0.0145
(1.00) 		7.22e-05
(0.129) 		1
(1.00) 		0.584
(1.00)
OR51V1 9 (4%) 215 0.00262
(1.00) 		0.00756
(1.00) 		0.0016
(1.00) 		0.799
(1.00) 		1
(1.00) 		0.000361
(0.639) 		2.77e-06
(0.005) 		1
(1.00) 		0.545
(1.00)
CSMD3 28 (12%) 196 0.00625
(1.00) 		0.0145
(1.00) 		0.00457
(1.00) 		0.19
(1.00) 		0.0678
(1.00) 		0.0221
(1.00) 		0.000129
(0.23) 		0.6
(1.00) 		0.0587
(1.00)
DCAF4L2 11 (5%) 213 0.00355
(1.00) 		0.0326
(1.00) 		0.027
(1.00) 		0.0276
(1.00) 		0.000116
(0.208) 		0.304
(1.00) 		0.545
(1.00)
RIMS1 15 (7%) 209 0.24
(1.00) 		0.423
(1.00) 		0.00135
(1.00) 		0.0193
(1.00) 		0.795
(1.00) 		0.0338
(1.00) 		0.000103
(0.183) 		0.458
(1.00) 		0.736
(1.00)
NRAS 20 (9%) 204 0.0358
(1.00) 		0.33
(1.00) 		0.274
(1.00) 		0.857
(1.00) 		0.676
(1.00) 		0.25
(1.00) 		0.636
(1.00) 		1
(1.00) 		1
(1.00)
PIK3CA 33 (15%) 191 0.194
(1.00) 		0.38
(1.00) 		0.00048
(0.844) 		0.0323
(1.00) 		0.0748
(1.00) 		0.0177
(1.00) 		0.000436
(0.768) 		0.0853
(1.00) 		1
(1.00)
APC 160 (71%) 64 0.0183
(1.00) 		0.00907
(1.00) 		0.221
(1.00) 		0.533
(1.00) 		0.374
(1.00) 		0.0164
(1.00) 		0.00922
(1.00) 		0.689
(1.00) 		0.464
(1.00)
SMAD4 26 (12%) 198 0.023
(1.00) 		0.134
(1.00) 		0.0355
(1.00) 		0.388
(1.00) 		0.162
(1.00) 		0.00333
(1.00) 		0.00127
(1.00) 		1
(1.00) 		0.846
(1.00)
FAM123B 25 (11%) 199 0.0765
(1.00) 		0.0348
(1.00) 		0.00539
(1.00) 		0.141
(1.00) 		0.945
(1.00) 		0.0084
(1.00) 		0.00267
(1.00) 		1
(1.00) 		0.459
(1.00)
TTN 85 (38%) 139 0.00535
(1.00) 		0.105
(1.00) 		0.00133
(1.00) 		0.657
(1.00) 		0.0909
(1.00) 		0.849
(1.00) 		0.0392
(1.00) 		0.000551
(0.967) 		0.151
(1.00) 		0.927
(1.00)
SMAD2 15 (7%) 209 0.114
(1.00) 		0.604
(1.00) 		0.0393
(1.00) 		0.286
(1.00) 		0.143
(1.00) 		0.265
(1.00) 		0.294
(1.00) 		1
(1.00) 		0.711
(1.00)
TCF7L2 18 (8%) 206 1
(1.00) 		0.311
(1.00) 		0.417
(1.00) 		0.355
(1.00) 		0.372
(1.00) 		0.238
(1.00) 		0.792
(1.00) 		1
(1.00) 		0.23
(1.00)
KRTAP5-5 4 (2%) 220 0.353
(1.00) 		1
(1.00) 		0.48
(1.00) 		0.172
(1.00) 		1
(1.00) 		0.579
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00)
ACVR1B 14 (6%) 210 0.109
(1.00) 		0.423
(1.00) 		0.0496
(1.00) 		0.463
(1.00) 		0.15
(1.00) 		0.0815
(1.00) 		0.0126
(1.00) 		0.435
(1.00) 		0.711
(1.00)
WBSCR17 19 (8%) 205 0.0966
(1.00) 		0.31
(1.00) 		0.141
(1.00) 		0.262
(1.00) 		0.267
(1.00) 		0.654
(1.00) 		0.0146
(1.00) 		0.544
(1.00) 		0.618
(1.00)
PCDH9 22 (10%) 202 0.727
(1.00) 		0.462
(1.00) 		0.0495
(1.00) 		0.875
(1.00) 		0.478
(1.00) 		0.489
(1.00) 		0.0447
(1.00) 		0.563
(1.00) 		1
(1.00)
LRP1B 39 (17%) 185 0.00288
(1.00) 		0.0211
(1.00) 		0.00332
(1.00) 		0.168
(1.00) 		1
(1.00) 		0.0113
(1.00) 		0.00162
(1.00) 		1
(1.00) 		0.087
(1.00)
TNFRSF10C 6 (3%) 218 0.376
(1.00) 		1
(1.00) 		0.675
(1.00) 		1
(1.00) 		0.236
(1.00) 		0.89
(1.00) 		0.622
(1.00) 		1
(1.00) 		1
(1.00)
MAP2K4 11 (5%) 213 0.0756
(1.00) 		0.423
(1.00) 		0.123
(1.00) 		0.336
(1.00) 		1
(1.00) 		0.497
(1.00) 		0.134
(1.00) 		1
(1.00) 		0.545
(1.00)
KIAA1804 15 (7%) 209 0.23
(1.00) 		0.411
(1.00) 		0.0659
(1.00) 		0.137
(1.00) 		0.614
(1.00) 		0.46
(1.00) 		0.575
(1.00) 		1
(1.00) 		0.736
(1.00)
NRXN1 20 (9%) 204 0.432
(1.00) 		0.354
(1.00) 		0.0843
(1.00) 		0.876
(1.00) 		0.696
(1.00) 		0.193
(1.00) 		0.0376
(1.00) 		1
(1.00) 		0.13
(1.00)
KLHL4 16 (7%) 208 0.0126
(1.00) 		0.0613
(1.00) 		0.00117
(1.00) 		0.387
(1.00) 		1
(1.00) 		0.0421
(1.00) 		0.0109
(1.00) 		0.41
(1.00) 		0.0126
(1.00)
SOX9 10 (4%) 214 0.142
(1.00) 		0.352
(1.00) 		0.00451
(1.00) 		0.519
(1.00) 		1
(1.00) 		0.839
(1.00) 		0.659
(1.00) 		1
(1.00) 		0.584
(1.00)
PRDM9 16 (7%) 208 0.00501
(1.00) 		1
(1.00) 		0.0701
(1.00) 		0.122
(1.00) 		0.86
(1.00) 		0.032
(1.00) 		0.22
(1.00) 		1
(1.00) 		0.255
(1.00)
PCBP1 6 (3%) 218 0.175
(1.00) 		0.244
(1.00) 		0.396
(1.00) 		0.163
(1.00) 		0.203
(1.00) 		1
(1.00) 		1
(1.00)
DMD 33 (15%) 191 0.0178
(1.00) 		0.0412
(1.00) 		0.0052
(1.00) 		0.624
(1.00) 		0.826
(1.00) 		0.0421
(1.00) 		0.00721
(1.00) 		1
(1.00) 		0.156
(1.00)
CSMD1 26 (12%) 198 0.152
(1.00) 		0.122
(1.00) 		0.0523
(1.00) 		1
(1.00) 		0.137
(1.00) 		0.739
(1.00) 		0.0885
(1.00) 		0.0155
(1.00) 		0.0581
(1.00) 		0.142
(1.00)
LIFR 18 (8%) 206 0.116
(1.00) 		0.579
(1.00) 		0.219
(1.00) 		0.579
(1.00) 		0.676
(1.00) 		0.251
(1.00) 		0.00809
(1.00) 		1
(1.00) 		0.064
(1.00)
OR6N1 10 (4%) 214 0.00197
(1.00) 		0.123
(1.00) 		0.013
(1.00) 		0.463
(1.00) 		1
(1.00) 		0.0167
(1.00) 		0.00422
(1.00) 		0.304
(1.00) 		1
(1.00)
CCDC160 7 (3%) 217 0.0679
(1.00) 		0.742
(1.00) 		0.108
(1.00) 		0.215
(1.00) 		1
(1.00) 		0.258
(1.00) 		0.499
(1.00) 		1
(1.00) 		0.0575
(1.00)
CNTN6 17 (8%) 207 0.153
(1.00) 		0.288
(1.00) 		0.0782
(1.00) 		0.266
(1.00) 		0.449
(1.00) 		0.333
(1.00) 		0.0051
(1.00) 		1
(1.00) 		0.322
(1.00)
CPXCR1 9 (4%) 215 0.00223
(1.00) 		0.407
(1.00) 		0.191
(1.00) 		0.519
(1.00) 		1
(1.00) 		0.347
(1.00) 		0.0523
(1.00) 		0.304
(1.00) 		0.0285
(1.00)
SLITRK1 15 (7%) 209 0.504
(1.00) 		0.881
(1.00) 		0.159
(1.00) 		0.206
(1.00) 		0.662
(1.00) 		0.963
(1.00) 		0.0496
(1.00) 		1
(1.00) 		0.181
(1.00)
CNBD1 7 (3%) 217 0.767
(1.00) 		1
(1.00) 		0.293
(1.00) 		0.258
(1.00) 		0.0835
(1.00) 		1
(1.00) 		0.406
(1.00)
CTNNB1 11 (5%) 213 0.763
(1.00) 		0.832
(1.00) 		0.048
(1.00) 		0.648
(1.00) 		0.525
(1.00) 		0.332
(1.00) 		0.061
(1.00) 		1
(1.00) 		0.545
(1.00)
DKK2 6 (3%) 218 0.0322
(1.00) 		0.0134
(1.00) 		0.628
(1.00) 		0.332
(1.00) 		0.871
(1.00) 		0.0371
(1.00) 		0.367
(1.00) 		1
(1.00) 		1
(1.00)
ERBB4 18 (8%) 206 0.115
(1.00) 		0.67
(1.00) 		0.00631
(1.00) 		0.118
(1.00) 		1
(1.00) 		0.000461
(0.811) 		0.165
(1.00) 		0.481
(1.00) 		0.76
(1.00)
ARID1A 21 (9%) 203 0.0216
(1.00) 		0.0883
(1.00) 		0.0136
(1.00) 		0.699
(1.00) 		0.438
(1.00) 		0.0585
(1.00) 		0.0238
(1.00) 		1
(1.00) 		0.064
(1.00)
KIAA1486 13 (6%) 211 0.337
(1.00) 		1
(1.00) 		0.306
(1.00) 		0.463
(1.00) 		1
(1.00) 		0.787
(1.00) 		0.481
(1.00) 		1
(1.00) 		0.0638
(1.00)
ROBO1 18 (8%) 206 0.0046
(1.00) 		0.0617
(1.00) 		0.0221
(1.00) 		0.0201
(1.00) 		0.871
(1.00) 		0.0274
(1.00) 		0.00173
(1.00) 		0.502
(1.00) 		0.281
(1.00)
ZFHX4 24 (11%) 200 0.703
(1.00) 		0.327
(1.00) 		0.0166
(1.00) 		0.699
(1.00) 		0.913
(1.00) 		0.594
(1.00) 		0.0452
(1.00) 		1
(1.00) 		0.072
(1.00)
EPHA3 16 (7%) 208 0.000438
(0.771) 		0.0299
(1.00) 		0.214
(1.00) 		0.313
(1.00) 		0.905
(1.00) 		0.0513
(1.00) 		0.000308
(0.546) 		1
(1.00) 		0.23
(1.00)
PRIM2 8 (4%) 216 0.285
(1.00) 		0.603
(1.00) 		0.889
(1.00) 		0.137
(1.00) 		0.636
(1.00) 		0.325
(1.00) 		0.611
(1.00) 		1
(1.00) 		0.406
(1.00)
UBE2NL 7 (3%) 217 0.102
(1.00) 		0.458
(1.00) 		0.402
(1.00) 		0.137
(1.00) 		1
(1.00) 		0.647
(1.00) 		0.15
(1.00) 		1
(1.00) 		0.351
(1.00)
ACVR2A 9 (4%) 215 0.00784
(1.00) 		0.452
(1.00) 		0.0325
(1.00) 		0.0487
(1.00) 		0.741
(1.00) 		0.0467
(1.00) 		0.0126
(1.00) 		1
(1.00) 		0.545
(1.00)
ADAM29 11 (5%) 213 0.45
(1.00) 		1
(1.00) 		0.447
(1.00) 		0.898
(1.00) 		0.318
(1.00) 		1
(1.00) 		0.545
(1.00)
ATP10A 19 (8%) 205 0.0169
(1.00) 		0.0882
(1.00) 		0.141
(1.00) 		0.000382
(0.675) 		0.365
(1.00) 		0.0319
(1.00) 		0.11
(1.00) 		1
(1.00) 		0.386
(1.00)
GABRA5 9 (4%) 215 0.473
(1.00) 		1
(1.00) 		0.756
(1.00) 		0.546
(1.00) 		0.0637
(1.00) 		0.244
(1.00) 		0.456
(1.00)
NALCN 20 (9%) 204 0.0365
(1.00) 		0.234
(1.00) 		0.141
(1.00) 		0.962
(1.00) 		0.757
(1.00) 		0.14
(1.00) 		0.0117
(1.00) 		1
(1.00) 		0.053
(1.00)
OTOL1 8 (4%) 216 0.131
(1.00) 		1
(1.00) 		0.943
(1.00) 		0.623
(1.00) 		0.145
(1.00) 		0.274
(1.00) 		0.502
(1.00)
PTEN 7 (3%) 217 0.0188
(1.00) 		0.78
(1.00) 		0.0429
(1.00) 		0.312
(1.00) 		0.636
(1.00) 		0.0334
(1.00) 		0.002
(1.00) 		0.244
(1.00) 		0.0575
(1.00)
TLL1 15 (7%) 209 0.0352
(1.00) 		0.596
(1.00) 		0.02
(1.00) 		0.0853
(1.00) 		0.236
(1.00) 		0.262
(1.00) 		0.0603
(1.00) 		0.359
(1.00) 		0.00952
(1.00)
TRPC4 17 (8%) 207 0.0046
(1.00) 		0.0827
(1.00) 		0.0139
(1.00) 		0.612
(1.00) 		0.162
(1.00) 		0.0231
(1.00) 		0.00421
(1.00) 		0.481
(1.00) 		0.171
(1.00)
ATM 25 (11%) 199 0.00284
(1.00) 		0.202
(1.00) 		0.000415
(0.731) 		0.325
(1.00) 		0.395
(1.00) 		0.015
(1.00) 		0.000574
(1.00) 		0.6
(1.00) 		0.162
(1.00)
GPC6 10 (4%) 214 0.568
(1.00) 		0.636
(1.00) 		0.509
(1.00) 		0.735
(1.00) 		1
(1.00) 		0.455
(1.00) 		0.598
(1.00) 		1
(1.00) 		1
(1.00)
CDH8 14 (6%) 210 0.00207
(1.00) 		0.00139
(1.00) 		0.124
(1.00) 		0.803
(1.00) 		0.478
(1.00) 		0.0504
(1.00) 		0.00103
(1.00) 		1
(1.00) 		1
(1.00)
MGC26647 7 (3%) 217 0.275
(1.00) 		0.78
(1.00) 		0.0498
(1.00) 		0.579
(1.00) 		0.741
(1.00) 		0.574
(1.00) 		0.15
(1.00) 		1
(1.00) 		0.351
(1.00)
DKK4 7 (3%) 217 0.297
(1.00) 		0.165
(1.00) 		0.402
(1.00) 		1
(1.00) 		1
(1.00) 		0.647
(1.00) 		0.575
(1.00) 		1
(1.00) 		1
(1.00)
PTPRM 20 (9%) 204 0.0446
(1.00) 		0.0145
(1.00) 		0.00293
(1.00) 		0.327
(1.00) 		0.568
(1.00) 		0.0772
(1.00) 		0.000589
(1.00) 		0.523
(1.00) 		0.0381
(1.00)
AFF2 17 (8%) 207 0.0472
(1.00) 		0.0612
(1.00) 		0.201
(1.00) 		0.528
(1.00) 		0.119
(1.00) 		0.0331
(1.00) 		0.0497
(1.00) 		0.481
(1.00) 		0.255
(1.00)
NCAM2 12 (5%) 212 0.0109
(1.00) 		0.451
(1.00) 		0.0617
(1.00) 		1
(1.00) 		1
(1.00) 		0.323
(1.00) 		0.00407
(1.00) 		1
(1.00) 		0.0387
(1.00)
OR2M4 8 (4%) 216 0.00906
(1.00) 		0.267
(1.00) 		0.0382
(1.00) 		0.463
(1.00) 		0.741
(1.00) 		0.0152
(1.00) 		0.242
(1.00) 		1
(1.00) 		0.502
(1.00)
RYR2 29 (13%) 195 0.0366
(1.00) 		0.248
(1.00) 		0.0195
(1.00) 		0.0123
(1.00) 		0.871
(1.00) 		0.0534
(1.00) 		0.00107
(1.00) 		0.6
(1.00) 		0.0755
(1.00)
CDH9 15 (7%) 209 0.153
(1.00) 		0.288
(1.00) 		0.0226
(1.00) 		0.0231
(1.00) 		0.449
(1.00) 		0.0952
(1.00) 		0.0294
(1.00) 		1
(1.00) 		0.158
(1.00)
GRIK3 17 (8%) 207 0.00763
(1.00) 		0.00174
(1.00) 		0.196
(1.00) 		0.163
(1.00) 		0.497
(1.00) 		0.148
(1.00) 		0.137
(1.00) 		1
(1.00) 		0.711
(1.00)
ELF3 6 (3%) 218 0.311
(1.00) 		1
(1.00) 		0.0514
(1.00) 		0.668
(1.00) 		0.318
(1.00) 		0.0509
(1.00) 		0.0382
(1.00) 		1
(1.00) 		0.406
(1.00)
TRPS1 17 (8%) 207 0.00936
(1.00) 		0.071
(1.00) 		0.00133
(1.00) 		0.0459
(1.00) 		1
(1.00) 		0.0101
(1.00) 		0.00057
(0.999) 		0.458
(1.00) 		0.354
(1.00)
FAM133A 7 (3%) 217 0.319
(1.00) 		0.78
(1.00) 		0.0183
(1.00) 		0.215
(1.00) 		0.636
(1.00) 		0.0783
(1.00) 		1
(1.00) 		1
(1.00) 		0.456
(1.00)
IL1RAPL2 10 (4%) 214 0.334
(1.00) 		0.636
(1.00) 		0.0473
(1.00) 		0.387
(1.00) 		0.817
(1.00) 		0.255
(1.00) 		0.398
(1.00) 		0.0412
(1.00) 		1
(1.00)
CCBP2 10 (4%) 214 0.149
(1.00) 		0.267
(1.00) 		0.623
(1.00) 		0.134
(1.00) 		0.905
(1.00) 		0.635
(1.00) 		0.398
(1.00) 		1
(1.00) 		0.162
(1.00)
OPCML 10 (4%) 214 0.321
(1.00) 		0.267
(1.00) 		0.543
(1.00) 		0.387
(1.00) 		0.236
(1.00) 		0.352
(1.00) 		0.543
(1.00) 		1
(1.00) 		0.0935
(1.00)
CDH18 13 (6%) 211 0.00173
(1.00) 		0.273
(1.00) 		0.0984
(1.00) 		0.0515
(1.00) 		0.905
(1.00) 		0.0996
(1.00) 		0.0493
(1.00) 		1
(1.00) 		0.62
(1.00)
OR2L13 10 (4%) 214 0.237
(1.00) 		0.599
(1.00) 		0.0275
(1.00) 		0.134
(1.00) 		0.739
(1.00) 		0.123
(1.00) 		0.221
(1.00) 		1
(1.00) 		1
(1.00)
BAI3 18 (8%) 206 0.00719
(1.00) 		0.47
(1.00) 		0.423
(1.00) 		0.592
(1.00) 		1
(1.00) 		0.304
(1.00) 		0.207
(1.00) 		1
(1.00) 		0.255
(1.00)
MGC42105 11 (5%) 213 0.00139
(1.00) 		0.172
(1.00) 		0.147
(1.00) 		0.0753
(1.00) 		0.119
(1.00) 		0.0167
(1.00) 		0.00422
(1.00) 		1
(1.00) 		1
(1.00)
TXNDC3 11 (5%) 213 0.00269
(1.00) 		0.293
(1.00) 		0.0125
(1.00) 		1
(1.00) 		0.0299
(1.00) 		0.0918
(1.00) 		0.00398
(1.00) 		1
(1.00) 		0.00311
(1.00)
LPPR4 13 (6%) 211 0.074
(1.00) 		0.0357
(1.00) 		0.0342
(1.00) 		0.799
(1.00) 		0.525
(1.00) 		0.223
(1.00) 		0.0738
(1.00) 		1
(1.00) 		0.653
(1.00)
UNC13C 17 (8%) 207 0.00713
(1.00) 		0.217
(1.00) 		0.0257
(1.00) 		0.0567
(1.00) 		0.86
(1.00) 		0.0612
(1.00) 		0.0827
(1.00) 		1
(1.00) 		0.255
(1.00)
SCN7A 15 (7%) 209 0.000649
(1.00) 		0.0609
(1.00) 		0.0492
(1.00) 		0.299
(1.00) 		0.913
(1.00) 		0.0111
(1.00) 		0.00632
(1.00) 		1
(1.00) 		0.205
(1.00)
ACOT4 3 (1%) 221 0.296
(1.00) 		0.302
(1.00) 		0.829
(1.00) 		1
(1.00) 		0.0713
(1.00) 		1
(1.00) 		1
(1.00)
GGT1 3 (1%) 221 0.254
(1.00) 		0.184
(1.00) 		0.377
(1.00) 		1
(1.00) 		1
(1.00)
GRIA1 15 (7%) 209 0.0535
(1.00) 		0.32
(1.00) 		0.0104
(1.00) 		0.558
(1.00) 		1
(1.00) 		0.0272
(1.00) 		0.00324
(1.00) 		1
(1.00) 		0.0226
(1.00)
ING1 6 (3%) 218 0.291
(1.00) 		0.709
(1.00) 		0.628
(1.00) 		0.458
(1.00) 		0.203
(1.00) 		1
(1.00) 		0.406
(1.00)
PCDHA10 10 (4%) 214 0.079
(1.00) 		0.355
(1.00) 		0.108
(1.00) 		0.62
(1.00) 		0.0318
(1.00) 		1
(1.00) 		0.545
(1.00)
ZNF208 11 (5%) 213 0.182
(1.00) 		1
(1.00) 		0.249
(1.00) 		0.558
(1.00) 		1
(1.00) 		0.399
(1.00) 		0.628
(1.00) 		1
(1.00) 		0.114
(1.00)
CRTC1 6 (3%) 218 0.122
(1.00) 		0.0889
(1.00) 		0.837
(1.00) 		0.312
(1.00) 		0.636
(1.00) 		0.228
(1.00) 		0.725
(1.00) 		1
(1.00) 		0.406
(1.00)
FAM5C 13 (6%) 211 0.0975
(1.00) 		0.601
(1.00) 		0.0186
(1.00) 		0.0231
(1.00) 		0.143
(1.00) 		0.466
(1.00) 		0.0353
(1.00) 		0.0711
(1.00) 		0.653
(1.00)
FAM22F 9 (4%) 215 0.69
(1.00) 		0.0958
(1.00) 		1
(1.00) 		0.915
(1.00) 		0.871
(1.00) 		0.749
(1.00) 		0.456
(1.00) 		1
(1.00) 		1
(1.00)
CHRDL1 11 (5%) 213 0.166
(1.00) 		0.821
(1.00) 		0.472
(1.00) 		0.246
(1.00) 		1
(1.00) 		0.215
(1.00) 		0.916
(1.00) 		1
(1.00) 		0.584
(1.00)
EDNRB 10 (4%) 214 0.0629
(1.00) 		1
(1.00) 		0.757
(1.00) 		0.0128
(1.00) 		0.905
(1.00) 		0.839
(1.00) 		0.0982
(1.00) 		1
(1.00) 		0.545
(1.00)
IFT80 10 (4%) 214 0.0879
(1.00) 		0.78
(1.00) 		0.254
(1.00) 		0.347
(1.00) 		0.0523
(1.00) 		0.304
(1.00) 		0.162
(1.00)
ANK2 30 (13%) 194 0.000689
(1.00) 		0.000889
(1.00) 		0.0015
(1.00) 		0.028
(1.00) 		0.614
(1.00) 		0.000963
(1.00) 		0.000734
(1.00) 		1
(1.00) 		0.0416
(1.00)
CASP14 8 (4%) 216 1
(1.00) 		0.23
(1.00) 		0.889
(1.00) 		1
(1.00) 		1
(1.00) 		0.526
(1.00) 		0.464
(1.00) 		0.274
(1.00) 		1
(1.00)
LASS3 9 (4%) 215 0.00355
(1.00) 		0.28
(1.00) 		0.104
(1.00) 		0.0946
(1.00) 		1
(1.00) 		0.0548
(1.00) 		0.0306
(1.00) 		1
(1.00) 		0.0747
(1.00)
P2RY10 7 (3%) 217 0.66
(1.00) 		0.402
(1.00) 		0.402
(1.00) 		0.459
(1.00) 		1
(1.00) 		0.237
(1.00) 		0.499
(1.00) 		1
(1.00) 		1
(1.00)
CNTN1 14 (6%) 210 0.0164
(1.00) 		0.193
(1.00) 		0.00405
(1.00) 		0.876
(1.00) 		0.696
(1.00) 		0.146
(1.00) 		0.00159
(1.00) 		1
(1.00) 		0.181
(1.00)
ISL1 8 (4%) 216 0.302
(1.00) 		0.452
(1.00) 		0.435
(1.00) 		1
(1.00) 		1
(1.00) 		0.235
(1.00) 		0.242
(1.00) 		1
(1.00) 		0.502
(1.00)
ARID2 15 (7%) 209 0.208
(1.00) 		0.221
(1.00) 		0.0254
(1.00) 		0.0459
(1.00) 		0.905
(1.00) 		0.231
(1.00) 		0.00632
(1.00) 		1
(1.00) 		0.0638
(1.00)
EIF4A2 5 (2%) 219 0.647
(1.00) 		0.182
(1.00) 		0.73
(1.00) 		0.558
(1.00) 		0.636
(1.00) 		0.216
(1.00) 		0.288
(1.00) 		1
(1.00) 		0.141
(1.00)
CDH11 14 (6%) 210 0.061
(1.00) 		0.273
(1.00) 		0.0175
(1.00) 		1
(1.00) 		1
(1.00) 		0.147
(1.00) 		0.0353
(1.00) 		0.385
(1.00) 		1
(1.00)
CHST9 8 (4%) 216 0.0111
(1.00) 		0.8
(1.00) 		0.0706
(1.00) 		0.0144
(1.00) 		0.0988
(1.00) 		1
(1.00) 		0.456
(1.00)
HTR3B 6 (3%) 218 0.13
(1.00) 		0.646
(1.00) 		0.628
(1.00) 		0.00853
(1.00) 		0.636
(1.00) 		0.587
(1.00) 		0.367
(1.00) 		1
(1.00) 		0.351
(1.00)
LRRIQ3 10 (4%) 214 0.167
(1.00) 		0.697
(1.00) 		0.157
(1.00) 		0.232
(1.00) 		0.437
(1.00) 		0.467
(1.00) 		0.221
(1.00) 		1
(1.00) 		0.114
(1.00)
HCN1 10 (4%) 214 0.344
(1.00) 		0.707
(1.00) 		0.0201
(1.00) 		0.735
(1.00) 		1
(1.00) 		0.24
(1.00) 		0.0423
(1.00) 		1
(1.00) 		1
(1.00)
CHRM2 10 (4%) 214 0.338
(1.00) 		0.599
(1.00) 		0.115
(1.00) 		0.648
(1.00) 		1
(1.00) 		0.123
(1.00) 		0.00607
(1.00) 		1
(1.00) 		0.545
(1.00)
DACH2 12 (5%) 212 0.123
(1.00) 		0.347
(1.00) 		0.256
(1.00) 		0.78
(1.00) 		0.0575
(1.00) 		1
(1.00) 		0.114
(1.00)
PCDH11X 14 (6%) 210 0.0179
(1.00) 		0.521
(1.00) 		0.107
(1.00) 		0.681
(1.00) 		1
(1.00) 		0.0559
(1.00) 		0.289
(1.00) 		1
(1.00) 		0.181
(1.00)
KCNA4 12 (5%) 212 0.101
(1.00) 		0.172
(1.00) 		0.00254
(1.00) 		0.0336
(1.00) 		0.528
(1.00) 		0.0486
(1.00) 		0.00407
(1.00) 		1
(1.00) 		0.584
(1.00)
DPP10 13 (6%) 211 0.00128
(1.00) 		0.601
(1.00) 		0.0895
(1.00) 		0.699
(1.00) 		0.542
(1.00) 		0.276
(1.00) 		0.0493
(1.00) 		0.385
(1.00) 		0.158
(1.00)
EVC2 17 (8%) 207 0.00338
(1.00) 		0.00644
(1.00) 		0.0383
(1.00) 		0.255
(1.00) 		0.144
(1.00) 		0.0125
(1.00) 		0.0597
(1.00) 		1
(1.00) 		0.711
(1.00)
C15ORF2 12 (5%) 212 0.0174
(1.00) 		0.452
(1.00) 		0.166
(1.00) 		0.232
(1.00) 		0.152
(1.00) 		0.131
(1.00) 		0.00398
(1.00) 		0.304
(1.00) 		0.0492
(1.00)
NLRP5 12 (5%) 212 0.159
(1.00) 		1
(1.00) 		0.0649
(1.00) 		0.025
(1.00) 		0.15
(1.00) 		0.00618
(1.00) 		0.0297
(1.00) 		1
(1.00) 		0.584
(1.00)
BTNL8 3 (1%) 221 0.296
(1.00) 		0.302
(1.00) 		0.254
(1.00) 		0.215
(1.00) 		1
(1.00) 		0.184
(1.00) 		0.227
(1.00) 		1
(1.00) 		1
(1.00)
KLK2 3 (1%) 221 0.468
(1.00) 		0.302
(1.00) 		0.829
(1.00) 		0.327
(1.00) 		0.227
(1.00) 		1
(1.00)
LUZP2 6 (3%) 218 0.0835
(1.00) 		0.202
(1.00) 		0.175
(1.00) 		0.126
(1.00) 		0.418
(1.00) 		0.182
(1.00) 		0.85
(1.00) 		1
(1.00) 		1
(1.00)
NXF5 7 (3%) 217 0.243
(1.00) 		0.863
(1.00) 		0.425
(1.00) 		0.215
(1.00) 		1
(1.00) 		0.732
(1.00) 		0.575
(1.00) 		1
(1.00) 		0.0421
(1.00)
PCDHB5 14 (6%) 210 0.148
(1.00) 		0.573
(1.00) 		0.0582
(1.00) 		0.492
(1.00) 		0.227
(1.00) 		0.211
(1.00) 		0.0185
(1.00) 		0.385
(1.00) 		0.653
(1.00)
LOXL2 9 (4%) 215 0.653
(1.00) 		0.707
(1.00) 		0.191
(1.00) 		0.0316
(1.00) 		0.328
(1.00) 		0.0156
(1.00) 		0.363
(1.00) 		1
(1.00) 		0.32
(1.00)
UBQLNL 5 (2%) 219 0.12
(1.00) 		0.173
(1.00) 		1
(1.00) 		0.133
(1.00) 		0.164
(1.00) 		1
(1.00) 		1
(1.00)
MYO1B 13 (6%) 211 0.00916
(1.00) 		0.0199
(1.00) 		0.00752
(1.00) 		0.0284
(1.00) 		1
(1.00) 		0.0119
(1.00) 		0.0108
(1.00) 		1
(1.00) 		0.653
(1.00)
SPATA17 9 (4%) 215 0.102
(1.00) 		0.486
(1.00) 		0.0519
(1.00) 		1
(1.00) 		0.817
(1.00) 		0.288
(1.00) 		0.0637
(1.00) 		1
(1.00) 		1
(1.00)
COL12A1 21 (9%) 203 0.01
(1.00) 		0.505
(1.00) 		0.0451
(1.00) 		0.148
(1.00) 		1
(1.00) 		0.0684
(1.00) 		0.0351
(1.00) 		0.523
(1.00) 		0.0753
(1.00)
JAKMIP2 13 (6%) 211 0.0146
(1.00) 		0.273
(1.00) 		0.0855
(1.00) 		0.283
(1.00) 		0.173
(1.00) 		0.0258
(1.00) 		0.0261
(1.00) 		0.385
(1.00) 		0.158
(1.00)
EPHA5 13 (6%) 211 0.0611
(1.00) 		0.117
(1.00) 		0.0666
(1.00) 		0.283
(1.00) 		0.452
(1.00) 		0.0612
(1.00) 		0.00538
(1.00) 		1
(1.00) 		0.653
(1.00)
ODZ1 22 (10%) 202 0.376
(1.00) 		0.312
(1.00) 		0.0474
(1.00) 		0.918
(1.00) 		0.413
(1.00) 		0.00842
(1.00) 		0.000214
(0.38) 		0.204
(1.00) 		0.669
(1.00)
POSTN 11 (5%) 213 0.0193
(1.00) 		0.108
(1.00) 		0.272
(1.00) 		0.681
(1.00) 		0.636
(1.00) 		0.407
(1.00) 		0.318
(1.00) 		1
(1.00) 		1
(1.00)
ZCWPW2 7 (3%) 217 0.344
(1.00) 		0.517
(1.00) 		1
(1.00) 		0.903
(1.00) 		0.437
(1.00) 		0.844
(1.00) 		0.367
(1.00) 		1
(1.00) 		0.104
(1.00)
ZEB2 15 (7%) 209 0.0402
(1.00) 		0.761
(1.00) 		0.164
(1.00) 		0.559
(1.00) 		1
(1.00) 		0.131
(1.00) 		0.0135
(1.00) 		0.385
(1.00) 		0.653
(1.00)
TUSC3 7 (3%) 217 0.00548
(1.00) 		0.136
(1.00) 		0.04
(1.00) 		0.558
(1.00) 		1
(1.00) 		0.0194
(1.00) 		0.000529
(0.929) 		1
(1.00) 		0.00375
(1.00)
CACNG7 6 (3%) 218 0.596
(1.00) 		0.322
(1.00) 		0.363
(1.00) 		0.126
(1.00) 		0.0541
(1.00) 		0.0605
(1.00) 		0.622
(1.00) 		1
(1.00) 		0.213
(1.00)
RWDD2B 8 (4%) 216 0.0518
(1.00) 		0.8
(1.00) 		0.182
(1.00) 		0.494
(1.00) 		0.242
(1.00) 		1
(1.00) 		0.00375
(1.00)
SLC25A13 7 (3%) 217 0.14
(1.00) 		0.349
(1.00) 		0.425
(1.00) 		0.232
(1.00) 		0.236
(1.00) 		0.381
(1.00) 		0.363
(1.00) 		1
(1.00) 		0.0421
(1.00)
DPF2 4 (2%) 220 0.468
(1.00) 		0.302
(1.00) 		0.381
(1.00) 		0.215
(1.00) 		0.0777
(1.00) 		0.327
(1.00) 		1
(1.00) 		1
(1.00) 		0.141
(1.00)
PCDH10 17 (8%) 207 0.0868
(1.00) 		0.113
(1.00) 		0.0139
(1.00) 		0.336
(1.00) 		0.696
(1.00) 		0.106
(1.00) 		0.000559
(0.98) 		1
(1.00) 		0.23
(1.00)
CDH12 13 (6%) 211 0.00479
(1.00) 		0.32
(1.00) 		0.0874
(1.00) 		0.0946
(1.00) 		0.236
(1.00) 		0.0186
(1.00) 		0.00927
(1.00) 		1
(1.00) 		0.00946
(1.00)
MCF2 12 (5%) 212 0.0808
(1.00) 		0.273
(1.00) 		0.263
(1.00) 		0.281
(1.00) 		0.817
(1.00) 		0.418
(1.00) 		0.121
(1.00) 		1
(1.00) 		0.135
(1.00)
NCKAP5 15 (7%) 209 0.0233
(1.00) 		0.0161
(1.00) 		0.131
(1.00) 		0.00216
(1.00) 		0.905
(1.00) 		0.0606
(1.00) 		0.000936
(1.00) 		1
(1.00) 		0.711
(1.00)
RIMS2 13 (6%) 211 0.00174
(1.00) 		0.32
(1.00) 		0.000306
(0.543) 		0.273
(1.00) 		1
(1.00) 		0.00301
(1.00) 		0.00538
(1.00) 		1
(1.00) 		0.653
(1.00)
ATP7A 6 (3%) 218 0.703
(1.00) 		1
(1.00) 		0.917
(1.00) 		0.205
(1.00) 		0.418
(1.00) 		0.844
(1.00) 		0.85
(1.00) 		1
(1.00) 		1
(1.00)
TPTE 12 (5%) 212 0.109
(1.00) 		0.461
(1.00) 		0.000369
(0.653) 		0.519
(1.00) 		1
(1.00) 		0.000818
(1.00) 		0.000394
(0.695) 		1
(1.00) 		0.62
(1.00)
OR8B4 6 (3%) 218 0.0679
(1.00) 		0.407
(1.00) 		0.206
(1.00) 		0.458
(1.00) 		0.203
(1.00) 		1
(1.00) 		0.351
(1.00)
SFMBT2 13 (6%) 211 0.541
(1.00) 		0.273
(1.00) 		0.387
(1.00) 		0.767
(1.00) 		1
(1.00) 		0.264
(1.00) 		0.00927
(1.00) 		1
(1.00) 		0.683
(1.00)
FLRT2 13 (6%) 211 0.138
(1.00) 		1
(1.00) 		0.019
(1.00) 		0.0552
(1.00) 		1
(1.00) 		0.369
(1.00) 		0.481
(1.00) 		1
(1.00) 		0.135
(1.00)
BCHE 9 (4%) 215 0.0539
(1.00) 		0.27
(1.00) 		0.314
(1.00) 		1
(1.00) 		1
(1.00) 		0.727
(1.00) 		0.0126
(1.00) 		1
(1.00) 		1
(1.00)
C8B 10 (4%) 214 0.0767
(1.00) 		0.27
(1.00) 		0.757
(1.00) 		0.668
(1.00) 		1
(1.00) 		0.635
(1.00) 		0.221
(1.00) 		1
(1.00) 		1
(1.00)
FREM2 23 (10%) 201 0.217
(1.00) 		0.381
(1.00) 		0.299
(1.00) 		0.105
(1.00) 		0.542
(1.00) 		0.384
(1.00) 		0.716
(1.00) 		0.6
(1.00) 		0.409
(1.00)
ZNF167 7 (3%) 217 0.275
(1.00) 		1
(1.00) 		0.0498
(1.00) 		0.825
(1.00) 		1
(1.00) 		0.237
(1.00) 		0.0163
(1.00) 		1
(1.00) 		0.406
(1.00)
GABRG1 8 (4%) 216 0.561
(1.00) 		0.707
(1.00) 		0.459
(1.00) 		0.474
(1.00) 		0.817
(1.00) 		0.126
(1.00) 		0.242
(1.00) 		1
(1.00) 		0.0747
(1.00)
SAT1 4 (2%) 220 0.00272
(1.00) 		0.0515
(1.00) 		0.0742
(1.00) 		0.825
(1.00) 		0.193
(1.00) 		0.0024
(1.00) 		0.0734
(1.00) 		1
(1.00) 		1
(1.00)
CHD4 17 (8%) 207 0.00951
(1.00) 		0.171
(1.00) 		0.000862
(1.00) 		0.492
(1.00) 		0.913
(1.00) 		0.000324
(0.574) 		0.000812
(1.00) 		1
(1.00) 		0.0101
(1.00)
PCDHB2 14 (6%) 210 0.0102
(1.00) 		0.0106
(1.00) 		0.0175
(1.00) 		0.648
(1.00) 		1
(1.00) 		0.0218
(1.00) 		0.00324
(1.00) 		1
(1.00) 		0.653
(1.00)
TMTC1 13 (6%) 211 0.169
(1.00) 		0.273
(1.00) 		0.0147
(1.00) 		0.0504
(1.00) 		0.328
(1.00) 		0.0836
(1.00) 		0.00538
(1.00) 		0.385
(1.00) 		0.158
(1.00)
SH3GL3 8 (4%) 216 0.102
(1.00) 		1
(1.00) 		0.596
(1.00) 		0.463
(1.00) 		1
(1.00) 		0.742
(1.00) 		0.464
(1.00) 		1
(1.00) 		0.133
(1.00)
ZFPM2 6 (3%) 218 0.0235
(1.00) 		0.646
(1.00) 		0.541
(1.00) 		0.0487
(1.00) 		0.318
(1.00) 		0.338
(1.00) 		0.164
(1.00) 		1
(1.00) 		0.0549
(1.00)
CACNG3 8 (4%) 216 0.0174
(1.00) 		0.27
(1.00) 		0.00923
(1.00) 		0.025
(1.00) 		0.318
(1.00) 		0.126
(1.00) 		0.0988
(1.00) 		0.274
(1.00) 		0.0747
(1.00)
POTEB 8 (4%) 216 0.307
(1.00) 		0.517
(1.00) 		0.287
(1.00) 		0.0388
(1.00) 		0.0125
(1.00) 		1
(1.00) 		1
(1.00)
GRIN2A 19 (8%) 205 0.392
(1.00) 		0.369
(1.00) 		0.0439
(1.00) 		0.592
(1.00) 		0.86
(1.00) 		0.357
(1.00) 		0.0648
(1.00) 		0.481
(1.00) 		0.76
(1.00)
NRXN3 17 (8%) 207 0.000398
(0.701) 		0.0827
(1.00) 		0.00293
(1.00) 		0.916
(1.00) 		0.179
(1.00) 		0.00121
(1.00) 		0.00057
(0.999) 		1
(1.00) 		0.736
(1.00)
OR7C1 6 (3%) 218 0.13
(1.00) 		0.0134
(1.00) 		0.541
(1.00) 		0.128
(1.00) 		0.0683
(1.00) 		1
(1.00) 		0.406
(1.00)
SPATA8 3 (1%) 221 0.312
(1.00) 		0.439
(1.00) 		0.751
(1.00) 		1
(1.00) 		0.104
(1.00)
OR2M2 6 (3%) 218 0.809
(1.00) 		0.562
(1.00) 		0.917
(1.00) 		0.528
(1.00) 		0.203
(1.00) 		1
(1.00) 		0.351
(1.00)
SORCS1 15 (7%) 209 0.236
(1.00) 		0.0518
(1.00) 		0.131
(1.00) 		0.936
(1.00) 		0.605
(1.00) 		0.149
(1.00) 		0.00632
(1.00) 		1
(1.00) 		0.205
(1.00)
IL18R1 10 (4%) 214 0.0354
(1.00) 		0.486
(1.00) 		0.254
(1.00) 		0.463
(1.00) 		1
(1.00) 		0.186
(1.00) 		0.0724
(1.00) 		1
(1.00) 		0.114
(1.00)
DPY19L1 5 (2%) 219 0.00985
(1.00) 		0.34
(1.00) 		0.194
(1.00) 		0.137
(1.00) 		1
(1.00) 		0.0911
(1.00) 		0.000861
(1.00) 		1
(1.00) 		0.292
(1.00)
C16ORF45 3 (1%) 221 0.137
(1.00) 		0.594
(1.00) 		0.108
(1.00) 		0.145
(1.00) 		0.227
(1.00) 		1
(1.00) 		1
(1.00)
INHBA 9 (4%) 215 0.00486
(1.00) 		0.27
(1.00) 		0.0706
(1.00) 		0.0318
(1.00) 		0.00354
(1.00) 		0.025
(1.00) 		0.0575
(1.00)
MIER3 11 (5%) 213 0.000174
(0.309) 		0.0182
(1.00) 		0.00207
(1.00) 		0.799
(1.00) 		1
(1.00) 		0.00185
(1.00) 		0.00057
(0.999) 		1
(1.00) 		0.62
(1.00)
ZNF585A 10 (4%) 214 0.00256
(1.00) 		0.293
(1.00) 		0.00451
(1.00) 		0.463
(1.00) 		0.0666
(1.00) 		0.0025
(1.00) 		0.000975
(1.00) 		1
(1.00) 		0.0935
(1.00)
TMPRSS13 4 (2%) 220 0.386
(1.00) 		1
(1.00) 		0.11
(1.00) 		0.21
(1.00) 		0.807
(1.00) 		1
(1.00) 		0.292
(1.00)
FSTL5 11 (5%) 213 0.0556
(1.00) 		0.172
(1.00) 		0.0316
(1.00) 		0.355
(1.00) 		0.542
(1.00) 		0.0399
(1.00) 		0.034
(1.00) 		1
(1.00) 		0.193
(1.00)
DOK5 6 (3%) 218 0.893
(1.00) 		0.481
(1.00) 		0.628
(1.00) 		0.459
(1.00) 		1
(1.00) 		0.0605
(1.00) 		0.367
(1.00) 		1
(1.00) 		0.213
(1.00)
ZNF99 11 (5%) 213 0.0467
(1.00) 		0.697
(1.00) 		0.0153
(1.00) 		0.137
(1.00) 		0.636
(1.00) 		0.00669
(1.00) 		0.00936
(1.00) 		1
(1.00) 		0.0387
(1.00)
GML 6 (3%) 218 0.412
(1.00) 		0.0684
(1.00) 		0.628
(1.00) 		0.458
(1.00) 		0.00787
(1.00) 		1
(1.00) 		1
(1.00)
B2M 5 (2%) 219 0.0413
(1.00) 		0.661
(1.00) 		0.0452
(1.00) 		0.215
(1.00) 		1
(1.00) 		0.0911
(1.00) 		0.0143
(1.00) 		1
(1.00) 		0.0288
(1.00)
PPP2R2B 3 (1%) 221 0.468
(1.00) 		1
(1.00) 		0.445
(1.00) 		1
(1.00) 		0.377
(1.00) 		1
(1.00) 		0.228
(1.00)
LRTM1 7 (3%) 217 0.0879
(1.00) 		0.458
(1.00) 		0.402
(1.00) 		0.647
(1.00) 		0.0835
(1.00) 		1
(1.00) 		0.351
(1.00)
OR10G9 6 (3%) 218 0.238
(1.00) 		0.709
(1.00) 		0.206
(1.00) 		0.458
(1.00) 		0.0365
(1.00) 		1
(1.00) 		0.351
(1.00)
ERBB3 14 (6%) 210 0.14
(1.00) 		0.0872
(1.00) 		0.124
(1.00) 		0.947
(1.00) 		0.739
(1.00) 		0.167
(1.00) 		0.0185
(1.00) 		1
(1.00) 		0.158
(1.00)
PSG8 8 (4%) 216 0.893
(1.00) 		0.0889
(1.00) 		0.107
(1.00) 		0.437
(1.00) 		0.411
(1.00) 		0.244
(1.00) 		0.249
(1.00)
SYT16 9 (4%) 215 0.071
(1.00) 		0.209
(1.00) 		0.182
(1.00) 		0.0336
(1.00) 		0.528
(1.00) 		0.115
(1.00) 		0.219
(1.00) 		0.304
(1.00) 		0.545
(1.00)
LPHN3 13 (6%) 211 0.00292
(1.00) 		0.252
(1.00) 		0.387
(1.00) 		0.148
(1.00) 		1
(1.00) 		0.327
(1.00) 		0.00927
(1.00) 		1
(1.00) 		0.135
(1.00)
LRP2 35 (16%) 189 0.00181
(1.00) 		0.0383
(1.00) 		0.0014
(1.00) 		0.523
(1.00) 		0.826
(1.00) 		0.0874
(1.00) 		0.0023
(1.00) 		0.342
(1.00) 		0.277
(1.00)
SOHLH2 9 (4%) 215 0.859
(1.00) 		0.0418
(1.00) 		0.327
(1.00) 		0.0219
(1.00) 		0.297
(1.00) 		0.0708
(1.00) 		0.0908
(1.00) 		1
(1.00) 		0.502
(1.00)
ZIM3 9 (4%) 215 0.0606
(1.00) 		0.9
(1.00) 		0.119
(1.00) 		0.00743
(1.00) 		0.817
(1.00) 		0.206
(1.00) 		0.57
(1.00) 		1
(1.00) 		0.0285
(1.00)
DSEL 14 (6%) 210 0.0128
(1.00) 		0.193
(1.00) 		0.00117
(1.00) 		0.336
(1.00) 		1
(1.00) 		0.0815
(1.00) 		0.0185
(1.00) 		1
(1.00) 		0.158
(1.00)
RNASE11 5 (2%) 219 0.767
(1.00) 		0.709
(1.00) 		0.148
(1.00) 		0.81
(1.00) 		0.164
(1.00) 		1
(1.00) 		0.0177
(1.00)
MDGA2 10 (4%) 214 0.102
(1.00) 		0.124
(1.00) 		0.0201
(1.00) 		0.735
(1.00) 		0.817
(1.00) 		0.058
(1.00) 		0.00422
(1.00) 		0.304
(1.00) 		1
(1.00)
RBMS3 6 (3%) 218 0.291
(1.00) 		0.842
(1.00) 		1
(1.00) 		0.844
(1.00) 		0.367
(1.00) 		1
(1.00) 		0.406
(1.00)
COL6A6 16 (7%) 208 0.0547
(1.00) 		0.573
(1.00) 		0.00426
(1.00) 		0.484
(1.00) 		0.452
(1.00) 		0.0375
(1.00) 		0.0294
(1.00) 		0.458
(1.00) 		0.736
(1.00)
TMBIM4 4 (2%) 220 1
(1.00) 		0.322
(1.00) 		0.65
(1.00) 		0.528
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00)
FAM135B 15 (7%) 209 0.0516
(1.00) 		0.273
(1.00) 		0.116
(1.00) 		0.772
(1.00) 		0.696
(1.00) 		0.00639
(1.00) 		0.00324
(1.00) 		0.107
(1.00) 		0.354
(1.00)
CYP7B1 7 (3%) 217 0.00985
(1.00) 		0.0462
(1.00) 		0.108
(1.00) 		0.00513
(1.00) 		1
(1.00) 		0.105
(1.00) 		0.00142
(1.00) 		1
(1.00) 		0.351
(1.00)
SLC16A7 9 (4%) 215 0.0275
(1.00) 		0.486
(1.00) 		0.119
(1.00) 		1
(1.00) 		0.297
(1.00) 		0.347
(1.00) 		0.0908
(1.00) 		1
(1.00) 		0.0747
(1.00)
'FBXW7 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.000122 (Fisher's exact test), Q value = 0.22

Table S1.  Gene #1: 'FBXW7 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
FBXW7 MUTATED 4 24 8 2
FBXW7 WILD-TYPE 82 59 28 14

Figure S1.  Get High-res Image Gene #1: 'FBXW7 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'BRAF MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1.13e-06 (Fisher's exact test), Q value = 0.002

Table S2.  Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
BRAF MUTATED 1 13 1 5
BRAF WILD-TYPE 57 31 67 32

Figure S2.  Get High-res Image Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'BRAF MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1.26e-07 (Fisher's exact test), Q value = 0.00023

Table S3.  Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 42 59 106
BRAF MUTATED 1 17 2
BRAF WILD-TYPE 41 42 104

Figure S3.  Get High-res Image Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'BRAF MUTATION STATUS' versus 'CN_CNMF'

P value = 4.17e-05 (Fisher's exact test), Q value = 0.075

Table S4.  Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
BRAF MUTATED 1 18 3 0
BRAF WILD-TYPE 85 65 33 16

Figure S4.  Get High-res Image Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'BRAF MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 3.49e-08 (Fisher's exact test), Q value = 6.3e-05

Table S5.  Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
BRAF MUTATED 1 16 5 0
BRAF WILD-TYPE 77 31 55 33

Figure S5.  Get High-res Image Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'BRAF MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1.92e-10 (Fisher's exact test), Q value = 3.5e-07

Table S6.  Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
BRAF MUTATED 19 2 1
BRAF WILD-TYPE 34 125 37

Figure S6.  Get High-res Image Gene #5: 'BRAF MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'KRAS MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1.94e-07 (Fisher's exact test), Q value = 0.00035

Table S7.  Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
KRAS MUTATED 21 15 44 12
KRAS WILD-TYPE 57 32 16 21

Figure S7.  Get High-res Image Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'KRAS MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 3.02e-07 (Fisher's exact test), Q value = 0.00055

Table S8.  Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
KRAS MUTATED 20 41 31
KRAS WILD-TYPE 33 86 7

Figure S8.  Get High-res Image Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'TP53 MUTATION STATUS' versus 'CN_CNMF'

P value = 7.28e-11 (Fisher's exact test), Q value = 1.3e-07

Table S9.  Gene #8: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
TP53 MUTATED 68 22 19 9
TP53 WILD-TYPE 18 61 17 7

Figure S9.  Get High-res Image Gene #8: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'FAT4 MUTATION STATUS' versus 'CN_CNMF'

P value = 6.63e-05 (Fisher's exact test), Q value = 0.12

Table S10.  Gene #13: 'FAT4 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
FAT4 MUTATED 6 27 3 2
FAT4 WILD-TYPE 80 56 33 14

Figure S10.  Get High-res Image Gene #13: 'FAT4 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'CDH2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 3.19e-05 (Fisher's exact test), Q value = 0.057

Table S11.  Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
CDH2 MUTATED 0 7 1 7
CDH2 WILD-TYPE 58 37 67 30

Figure S11.  Get High-res Image Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'CDH2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 5.18e-05 (Fisher's exact test), Q value = 0.093

Table S12.  Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
CDH2 MUTATED 0 6 10 0
CDH2 WILD-TYPE 78 41 50 33

Figure S12.  Get High-res Image Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'CDH2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1.1e-05 (Fisher's exact test), Q value = 0.02

Table S13.  Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
CDH2 MUTATED 10 1 5
CDH2 WILD-TYPE 43 126 33

Figure S13.  Get High-res Image Gene #35: 'CDH2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'FLG MUTATION STATUS' versus 'MRNA_CNMF'

P value = 2.36e-06 (Fisher's exact test), Q value = 0.0043

Table S14.  Gene #40: 'FLG MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
FLG MUTATED 0 14 6 8
FLG WILD-TYPE 58 30 62 29

Figure S14.  Get High-res Image Gene #40: 'FLG MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'FLG MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 4.08e-05 (Fisher's exact test), Q value = 0.073

Table S15.  Gene #40: 'FLG MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
FLG MUTATED 18 9 5
FLG WILD-TYPE 35 118 33

Figure S15.  Get High-res Image Gene #40: 'FLG MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'DNAH5 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00013 (Fisher's exact test), Q value = 0.23

Table S16.  Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
DNAH5 MUTATED 4 24 4 2
DNAH5 WILD-TYPE 82 59 32 14

Figure S16.  Get High-res Image Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'DNAH5 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 7.52e-05 (Fisher's exact test), Q value = 0.13

Table S17.  Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
DNAH5 MUTATED 3 15 13 3
DNAH5 WILD-TYPE 75 32 47 30

Figure S17.  Get High-res Image Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'DNAH5 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1.52e-06 (Fisher's exact test), Q value = 0.0027

Table S18.  Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
DNAH5 MUTATED 20 8 6
DNAH5 WILD-TYPE 33 119 32

Figure S18.  Get High-res Image Gene #51: 'DNAH5 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'SDK1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000102 (Fisher's exact test), Q value = 0.18

Table S19.  Gene #56: 'SDK1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
SDK1 MUTATED 16 8 3
SDK1 WILD-TYPE 37 119 35

Figure S19.  Get High-res Image Gene #56: 'SDK1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'TMEM132D MUTATION STATUS' versus 'MRNA_CNMF'

P value = 2.85e-05 (Fisher's exact test), Q value = 0.051

Table S20.  Gene #58: 'TMEM132D MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
TMEM132D MUTATED 1 11 1 3
TMEM132D WILD-TYPE 57 33 67 34

Figure S20.  Get High-res Image Gene #58: 'TMEM132D MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'LRRN3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 9.57e-05 (Fisher's exact test), Q value = 0.17

Table S21.  Gene #80: 'LRRN3 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
LRRN3 MUTATED 0 8 2 0
LRRN3 WILD-TYPE 78 39 58 33

Figure S21.  Get High-res Image Gene #80: 'LRRN3 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'GUCY1A3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 7.22e-05 (Fisher's exact test), Q value = 0.13

Table S22.  Gene #95: 'GUCY1A3 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
GUCY1A3 MUTATED 9 1 2
GUCY1A3 WILD-TYPE 44 126 36

Figure S22.  Get High-res Image Gene #95: 'GUCY1A3 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'OR51V1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 2.77e-06 (Fisher's exact test), Q value = 0.005

Table S23.  Gene #108: 'OR51V1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
OR51V1 MUTATED 9 0 0
OR51V1 WILD-TYPE 44 127 38

Figure S23.  Get High-res Image Gene #108: 'OR51V1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'ZC3H13 MUTATION STATUS' versus 'CN_CNMF'

P value = 8.41e-05 (Fisher's exact test), Q value = 0.15

Table S24.  Gene #109: 'ZC3H13 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
ZC3H13 MUTATED 2 18 1 0
ZC3H13 WILD-TYPE 84 65 35 16

Figure S24.  Get High-res Image Gene #109: 'ZC3H13 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'ZC3H13 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 6.7e-05 (Fisher's exact test), Q value = 0.12

Table S25.  Gene #109: 'ZC3H13 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
ZC3H13 MUTATED 13 4 4
ZC3H13 WILD-TYPE 40 123 34

Figure S25.  Get High-res Image Gene #109: 'ZC3H13 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'CSMD3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000129 (Fisher's exact test), Q value = 0.23

Table S26.  Gene #116: 'CSMD3 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
CSMD3 MUTATED 16 8 4
CSMD3 WILD-TYPE 37 119 34

Figure S26.  Get High-res Image Gene #116: 'CSMD3 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'DCAF4L2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000116 (Fisher's exact test), Q value = 0.21

Table S27.  Gene #117: 'DCAF4L2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
DCAF4L2 MUTATED 9 1 1
DCAF4L2 WILD-TYPE 44 126 37

Figure S27.  Get High-res Image Gene #117: 'DCAF4L2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'DOCK2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.000122 (Fisher's exact test), Q value = 0.22

Table S28.  Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
DOCK2 MUTATED 1 8 1 7
DOCK2 WILD-TYPE 57 36 67 30

Figure S28.  Get High-res Image Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'DOCK2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.000138 (Fisher's exact test), Q value = 0.25

Table S29.  Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
DOCK2 MUTATED 1 17 2 1
DOCK2 WILD-TYPE 85 66 34 15

Figure S29.  Get High-res Image Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'DOCK2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1.35e-05 (Fisher's exact test), Q value = 0.024

Table S30.  Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 78 47 60 33
DOCK2 MUTATED 0 8 12 1
DOCK2 WILD-TYPE 78 39 48 32

Figure S30.  Get High-res Image Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #7: 'MRNASEQ_CNMF'

'DOCK2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 7.91e-07 (Fisher's exact test), Q value = 0.0014

Table S31.  Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
DOCK2 MUTATED 14 2 5
DOCK2 WILD-TYPE 39 125 33

Figure S31.  Get High-res Image Gene #119: 'DOCK2 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'RIMS1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000103 (Fisher's exact test), Q value = 0.18

Table S32.  Gene #135: 'RIMS1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
RIMS1 MUTATED 11 3 1
RIMS1 WILD-TYPE 42 124 37

Figure S32.  Get High-res Image Gene #135: 'RIMS1 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'CDH10 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 4.46e-05 (Fisher's exact test), Q value = 0.08

Table S33.  Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
CDH10 MUTATED 0 4 1 8
CDH10 WILD-TYPE 58 40 67 29

Figure S33.  Get High-res Image Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'CDH10 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.000131 (Fisher's exact test), Q value = 0.23

Table S34.  Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
CDH10 MUTATED 0 13 1 0
CDH10 WILD-TYPE 86 70 35 16

Figure S34.  Get High-res Image Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

'CDH10 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 2.68e-05 (Fisher's exact test), Q value = 0.048

Table S35.  Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 53 127 38
CDH10 MUTATED 11 2 1
CDH10 WILD-TYPE 42 125 37

Figure S35.  Get High-res Image Gene #138: 'CDH10 MUTATION STATUS' versus Clinical Feature #8: 'MRNASEQ_CHIERARCHICAL'

'SYNE1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 2.86e-05 (Fisher's exact test), Q value = 0.051

Table S36.  Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 58 44 68 37
SYNE1 MUTATED 8 14 6 17
SYNE1 WILD-TYPE 50 30 62 20

Figure S36.  Get High-res Image Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #1: 'MRNA_CNMF'

'SYNE1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 2.56e-05 (Fisher's exact test), Q value = 0.046

Table S37.  Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients CLUS_1 CLUS_2 CLUS_3
ALL 42 59 106
SYNE1 MUTATED 3 25 17
SYNE1 WILD-TYPE 39 34 89

Figure S37.  Get High-res Image Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'SYNE1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1.63e-06 (Fisher's exact test), Q value = 0.0029

Table S38.  Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

nPatients CLUS_1 CLUS_2 CLUS_3 CLUS_4
ALL 86 83 36 16
SYNE1 MUTATED 7 32 6 0
SYNE1 WILD-TYPE 79 51 30 16

Figure S38.  Get High-res Image Gene #142: 'SYNE1 MUTATION STATUS' versus Clinical Feature #3: 'CN_CNMF'

Methods & Data
Input

  • Mutation data file = COADREAD-TP.mutsig.cluster.txt

  • Molecular subtypes file = COADREAD-TP.transferedmergedcluster.txt

  • Number of patients = 224

  • Number of significantly mutated genes = 209

  • Number of Molecular subtypes = 10

  • Exclude genes that fewer than K tumors have mutations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

References
[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[2] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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