Mutation Analysis (MutSig vS2N)
Bladder Urothelial Carcinoma (Primary solid tumor)
22 February 2013  |  analyses__2013_02_22
Maintainer Information
Citation Information
doi:10.7908/C1057D3R
Maintained by Dan DiCara (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): Mutation Analysis (MutSig vS2N). Broad Institute of MIT and Harvard. doi:10.7908/C1057D3R
- Overview
+ Introduction
- Summary
- Results
- Significantly Mutated Genes

Column Descriptions:

  • N = number of sequenced bases in this gene across the individual set

  • nnon = number of (nonsilent) mutations in this gene across the individual set

  • nnull = number of (nonsilent) null mutations in this gene across the individual set

  • nflank = number of noncoding mutations from this gene's flanking region, across the individual set

  • nsil = number of silent mutations in this gene across the individual set

  • p = p-value (overall)

  • q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

Table 1.  Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 29. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

gene N nflank nsil nnon nnull p q
TP53 3528 0 1 14 3 0 0
KDM6A 12824 0 2 6 6 1.6e-131 1.5e-127
PRX 9548 0 0 9 1 5.2e-61 3.3e-57
ARID1A 16296 0 1 8 5 1e-53 4.9e-50
GOLGB1 34720 0 2 12 3 2e-28 7.5e-25
ASXL2 12600 0 0 6 2 2.8e-18 8.8e-15
FBXW7 8036 0 0 6 2 8.7e-17 2.3e-13
MLL 36344 0 1 9 2 1.4e-16 3.3e-13
FLG 30520 0 1 8 0 1.4e-15 2.9e-12
HRNR 15036 0 0 6 0 1.9e-15 3.7e-12
HCN1 8148 0 1 5 3 1.1e-14 1.9e-11
TTN 356944 0 3 34 4 2.8e-14 4.4e-11
BCLAF1 9072 0 0 5 1 2.9e-13 4.2e-10
MACF1 85736 0 0 9 1 1.8e-11 2.4e-08
RPAP1 10640 0 0 5 0 2e-11 2.5e-08
HMCN1 55132 0 0 9 2 3.6e-11 4.2e-08
ADAMTS12 15260 0 1 4 0 9.3e-10 1e-06
DCC 13580 0 1 5 0 4.1e-09 4.3e-06
MLL2 35028 0 0 6 6 1.7e-08 0.000017
ABCA10 17556 0 0 5 2 3.3e-07 0.00031
XPR1 7476 0 1 5 2 9.3e-07 0.00084
CREBBP 20384 0 1 5 3 2.6e-06 0.0022
SETD2 20664 0 0 5 3 3.1e-06 0.0025
SACS 47628 0 2 6 2 0.000023 0.017
DNAH5 49336 0 1 7 1 0.000023 0.017
SPTA1 24696 0 0 5 0 0.000024 0.018
APOB 49140 0 0 6 0 0.000031 0.022
GPS2 3192 0 0 4 3 0.000033 0.022
TPR 26152 0 1 5 0 0.000044 0.029
CSMD3 37184 0 1 5 1 0.00019 0.12
LAMA3 31220 0 0 5 2 0.00022 0.14
SDPR 4116 0 0 4 1 0.00031 0.18
OTUD7A 4956 0 0 4 0 0.0012 0.68
SPATS2 5376 0 0 4 1 0.002 1
KPNA3 5628 0 0 4 1 0.0026 1
+ Methods & Data
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