PARADIGM pathway analysis of mRNA expression data
Colon/Rectal Adenocarcinoma (Primary solid tumor)
22 February 2013  |  analyses__2013_02_22
Maintainer Information
Citation Information
doi:10.7908/C1XK8CQ9
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): PARADIGM pathway analysis of mRNA expression data. Broad Institute of MIT and Harvard. doi:10.7908/C1XK8CQ9
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 46 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
TCGA08_retinoblastoma 134
Syndecan-1-mediated signaling events 83
Signaling events mediated by Stem cell factor receptor (c-Kit) 64
FAS signaling pathway (CD95) 63
BCR signaling pathway 54
FOXM1 transcription factor network 51
Fc-epsilon receptor I signaling in mast cells 47
Glypican 1 network 45
HIF-1-alpha transcription factor network 39
Reelin signaling pathway 34
Results
Summary Table

The following list describes the columns found in ##REF##406.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
TCGA08_retinoblastoma 134 1075 8 -0.48 0.25 1000 -1000 -0.022 -1000
Syndecan-1-mediated signaling events 83 2830 34 -0.7 0.017 1000 -1000 -0.096 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 64 4993 78 -0.99 0.28 1000 -1000 -0.089 -1000
FAS signaling pathway (CD95) 63 2970 47 -0.41 0.2 1000 -1000 -0.063 -1000
BCR signaling pathway 54 5406 99 -0.48 0.017 1000 -1000 -0.12 -1000
FOXM1 transcription factor network 51 2608 51 -0.68 0.017 1000 -1000 -0.17 -1000
Fc-epsilon receptor I signaling in mast cells 47 4603 97 -0.43 0.064 1000 -1000 -0.12 -1000
Glypican 1 network 45 2196 48 -0.48 0.03 1000 -1000 -0.063 -1000
HIF-1-alpha transcription factor network 39 2981 76 -0.82 0.028 1000 -1000 -0.13 -1000
Reelin signaling pathway 34 1942 56 -0.63 0.017 1000 -1000 -0.11 -1000
IL23-mediated signaling events 34 2049 60 -0.63 0.018 1000 -1000 -0.15 -1000
Endothelins 32 3145 96 -0.53 0.083 1000 -1000 -0.086 -1000
IL6-mediated signaling events 28 2167 75 -0.48 0.072 1000 -1000 -0.096 -1000
Osteopontin-mediated events 27 1040 38 -0.48 0.018 1000 -1000 -0.14 -1000
Canonical Wnt signaling pathway 26 1362 51 -0.54 0.37 1000 -1000 -0.071 -1000
Arf6 signaling events 25 1554 62 -0.32 0.018 1000 -1000 -0.076 -1000
BMP receptor signaling 25 2057 81 -0.45 0.032 1000 -1000 -0.11 -1000
Wnt signaling 25 176 7 -0.14 0.014 1000 -1000 -0.039 -1000
Visual signal transduction: Rods 25 1315 52 -0.45 0.017 1000 -1000 -0.12 -1000
TCGA08_p53 23 167 7 -0.16 0.087 1000 -1000 -0.013 -1000
Syndecan-2-mediated signaling events 22 1543 69 -0.67 0.053 1000 -1000 -0.072 -1000
Signaling events mediated by PRL 22 750 34 -0.21 0.1 1000 -1000 -0.084 -1000
IL4-mediated signaling events 21 1969 91 -0.56 0.38 1000 -1000 -0.16 -1000
Syndecan-3-mediated signaling events 21 741 35 -0.67 0.017 1000 -1000 -0.095 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 20 1123 54 -0.63 0.036 1000 -1000 -0.12 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 20 1753 85 -0.32 0.023 1000 -1000 -0.095 -1000
HIF-2-alpha transcription factor network 20 876 43 -0.67 0.38 1000 -1000 -0.1 -1000
Glucocorticoid receptor regulatory network 19 2275 114 -0.69 0.34 1000 -1000 -0.091 -1000
Presenilin action in Notch and Wnt signaling 18 1113 61 -0.54 0.24 1000 -1000 -0.095 -1000
IL1-mediated signaling events 18 1154 62 -0.41 0.082 1000 -1000 -0.12 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 18 1252 68 -0.84 0.076 1000 -1000 -0.13 -1000
EGFR-dependent Endothelin signaling events 18 381 21 -0.21 0.017 1000 -1000 -0.093 -1000
Aurora A signaling 17 1046 60 -0.69 0.021 1000 -1000 -0.086 -1000
TRAIL signaling pathway 15 749 48 -0.15 0.017 1000 -1000 -0.088 -1000
Calcium signaling in the CD4+ TCR pathway 15 475 31 -0.38 0.028 1000 -1000 -0.1 -1000
IL12-mediated signaling events 14 1268 87 -0.34 0.031 1000 -1000 -0.13 -1000
PLK1 signaling events 14 1271 85 -0.38 0.02 1000 -1000 -0.064 -1000
Regulation of nuclear SMAD2/3 signaling 13 1769 136 -1.1 0.068 1000 -1000 -0.095 -1000
p75(NTR)-mediated signaling 13 1632 125 -0.81 0.067 1000 -1000 -0.13 -1000
FOXA2 and FOXA3 transcription factor networks 13 611 46 -0.8 0.034 1000 -1000 -0.068 -1000
IL2 signaling events mediated by PI3K 13 774 58 -0.61 0.043 1000 -1000 -0.11 -1000
IGF1 pathway 13 774 57 -0.35 0.076 1000 -1000 -0.12 -1000
Noncanonical Wnt signaling pathway 12 319 26 -0.14 0.017 1000 -1000 -0.11 -1000
amb2 Integrin signaling 12 1055 82 -0.36 0.017 1000 -1000 -0.099 -1000
S1P1 pathway 12 432 36 -0.14 0.017 1000 -1000 -0.094 -1000
EPHB forward signaling 12 1033 85 -0.25 0.17 1000 -1000 -0.12 -1000
Thromboxane A2 receptor signaling 11 1241 105 -0.49 0.12 1000 -1000 -0.097 -1000
Ephrin B reverse signaling 11 567 48 -0.26 0.15 1000 -1000 -0.096 -1000
Visual signal transduction: Cones 10 382 38 -0.2 0.025 1000 -1000 -0.093 -1000
Nectin adhesion pathway 10 656 63 -0.7 0.058 1000 -1000 -0.1 -1000
Ceramide signaling pathway 10 798 76 -0.41 0.09 1000 -1000 -0.083 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 10 849 83 -0.41 0.089 1000 -1000 -0.1 -1000
Signaling events mediated by the Hedgehog family 9 475 52 -0.19 0.16 1000 -1000 -0.11 -1000
ceramide signaling pathway 9 445 49 -0.41 0.085 1000 -1000 -0.058 -1000
Glypican 2 network 9 36 4 -0.029 0 1000 -1000 -0.027 -1000
Regulation of Telomerase 9 935 102 -0.42 0.061 1000 -1000 -0.14 -1000
Syndecan-4-mediated signaling events 9 639 67 -0.48 0.03 1000 -1000 -0.12 -1000
Aurora B signaling 9 631 67 -0.27 0.03 1000 -1000 -0.095 -1000
PLK2 and PLK4 events 8 26 3 -0.006 -0.002 1000 -1000 -0.017 -1000
EPO signaling pathway 8 468 55 -0.57 0.024 1000 -1000 -0.11 -1000
PDGFR-alpha signaling pathway 8 394 44 -0.18 0.033 1000 -1000 -0.074 -1000
Integrins in angiogenesis 8 728 84 -0.48 0.065 1000 -1000 -0.12 -1000
TCR signaling in naïve CD8+ T cells 8 755 93 -0.095 0.044 1000 -1000 -0.099 -1000
Cellular roles of Anthrax toxin 7 290 39 -0.063 0.017 1000 -1000 -0.047 -1000
Signaling events mediated by PTP1B 7 558 76 -0.6 0.11 1000 -1000 -0.1 -1000
RXR and RAR heterodimerization with other nuclear receptor 7 405 52 -0.54 0.1 1000 -1000 -0.085 -1000
IL27-mediated signaling events 7 361 51 -0.31 0.024 1000 -1000 -0.099 -1000
VEGFR1 specific signals 7 404 56 -0.067 0.041 1000 -1000 -0.1 -1000
Regulation of Androgen receptor activity 7 520 70 -0.59 0.041 1000 -1000 -0.079 -1000
Ras signaling in the CD4+ TCR pathway 7 131 17 -0.09 0.017 1000 -1000 -0.053 -1000
Sphingosine 1-phosphate (S1P) pathway 6 173 28 -0.072 0.017 1000 -1000 -0.069 -1000
Signaling events mediated by HDAC Class III 6 260 40 -0.28 0.031 1000 -1000 -0.049 -1000
Signaling mediated by p38-alpha and p38-beta 6 298 44 -0.21 0.017 1000 -1000 -0.073 -1000
TCGA08_rtk_signaling 6 157 26 -0.32 0.036 1000 -1000 -0.027 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 6 206 33 -0.23 0.038 1000 -1000 -0.09 -1000
E-cadherin signaling events 6 30 5 -0.027 0.017 1000 -1000 -0.078 -1000
Canonical NF-kappaB pathway 5 224 39 -0.22 0.064 1000 -1000 -0.11 -1000
ErbB4 signaling events 5 393 69 -0.49 0.089 1000 -1000 -0.11 -1000
BARD1 signaling events 5 334 57 -0.16 0.052 1000 -1000 -0.085 -1000
a4b1 and a4b7 Integrin signaling 5 26 5 -0.023 0.011 1000 -1000 -0.056 -1000
Nongenotropic Androgen signaling 5 311 52 -0.07 0.048 1000 -1000 -0.078 -1000
Signaling events mediated by VEGFR1 and VEGFR2 5 700 125 -0.1 0.078 1000 -1000 -0.13 -1000
Stabilization and expansion of the E-cadherin adherens junction 5 403 74 -0.35 0.086 1000 -1000 -0.13 -1000
Class I PI3K signaling events 5 430 73 -0.3 0.033 1000 -1000 -0.081 -1000
Plasma membrane estrogen receptor signaling 5 491 86 -0.35 0.062 1000 -1000 -0.1 -1000
Coregulation of Androgen receptor activity 4 336 76 -0.22 0.063 1000 -1000 -0.077 -1000
IFN-gamma pathway 4 332 68 -0.14 0.057 1000 -1000 -0.12 -1000
Signaling mediated by p38-gamma and p38-delta 4 68 15 -0.033 0.039 1000 -1000 -0.048 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 4 217 45 -0.16 0.089 1000 -1000 -0.11 -1000
Effects of Botulinum toxin 4 119 26 -0.079 0.017 1000 -1000 -0.085 -1000
PDGFR-beta signaling pathway 4 430 97 -0.26 0.066 1000 -1000 -0.11 -1000
Caspase cascade in apoptosis 3 276 74 -0.22 0.061 1000 -1000 -0.067 -1000
FoxO family signaling 3 238 64 -0.11 0.13 1000 -1000 -0.089 -1000
Regulation of p38-alpha and p38-beta 3 188 54 -0.17 0.037 1000 -1000 -0.085 -1000
IL2 signaling events mediated by STAT5 3 71 22 -0.092 0.11 1000 -1000 -0.042 -1000
S1P3 pathway 3 155 42 -0.068 0.029 1000 -1000 -0.073 -1000
Angiopoietin receptor Tie2-mediated signaling 3 295 88 -0.26 0.099 1000 -1000 -0.14 -1000
Nephrin/Neph1 signaling in the kidney podocyte 2 90 34 -0.033 0.059 1000 -1000 -0.088 -1000
Circadian rhythm pathway 2 58 22 -0.075 0.066 1000 -1000 -0.089 -1000
Ephrin A reverse signaling 2 16 7 -0.006 0.027 1000 -1000 -0.04 -1000
JNK signaling in the CD4+ TCR pathway 2 44 17 -0.089 0.056 1000 -1000 -0.092 -1000
Hedgehog signaling events mediated by Gli proteins 2 153 65 -0.15 0.067 1000 -1000 -0.084 -1000
Arf6 downstream pathway 2 90 43 -0.036 0.037 1000 -1000 -0.065 -1000
Paxillin-independent events mediated by a4b1 and a4b7 2 107 37 -0.13 0.043 1000 -1000 -0.11 -1000
Retinoic acid receptors-mediated signaling 2 132 58 -0.068 0.079 1000 -1000 -0.089 -1000
LPA receptor mediated events 2 278 102 -0.32 0.056 1000 -1000 -0.096 -1000
E-cadherin signaling in the nascent adherens junction 2 203 76 -0.057 0.061 1000 -1000 -0.12 -1000
Arf6 trafficking events 2 147 71 -0.17 0.059 1000 -1000 -0.11 -1000
Insulin Pathway 2 165 74 -0.081 0.052 1000 -1000 -0.12 -1000
Neurotrophic factor-mediated Trk receptor signaling 2 343 120 -0.061 0.1 1000 -1000 -0.098 -1000
LPA4-mediated signaling events 1 19 12 -0.002 0.045 1000 -1000 -0.031 -1000
ErbB2/ErbB3 signaling events 1 73 65 -0.017 0.092 1000 -1000 -0.088 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 1 39 23 -0.019 0.045 1000 -1000 -0.097 -1000
Signaling events mediated by HDAC Class II 1 123 75 -0.085 0.044 1000 -1000 -0.079 -1000
Insulin-mediated glucose transport 1 32 32 -0.054 0.051 1000 -1000 -0.073 -1000
mTOR signaling pathway 1 77 53 -0.007 0.068 1000 -1000 -0.079 -1000
Class I PI3K signaling events mediated by Akt 1 74 68 -0.094 0.062 1000 -1000 -0.1 -1000
Signaling events regulated by Ret tyrosine kinase 1 82 82 -0.04 0.068 1000 -1000 -0.11 -1000
S1P5 pathway 1 30 17 -0.07 0.025 1000 -1000 -0.069 -1000
Paxillin-dependent events mediated by a4b1 1 36 36 -0.023 0.031 1000 -1000 -0.098 -1000
E-cadherin signaling in keratinocytes 1 73 43 -0.35 0.045 1000 -1000 -0.095 -1000
S1P4 pathway 1 46 25 -0.07 0.033 1000 -1000 -0.059 -1000
Arf1 pathway 1 56 54 -0.014 0.048 1000 -1000 -0.071 -1000
Aurora C signaling 0 6 7 -0.006 0.017 1000 -1000 -0.06 -1000
Signaling events mediated by HDAC Class I 0 52 104 -0.025 0.078 1000 -1000 -0.095 -1000
Atypical NF-kappaB pathway 0 11 31 -0.003 0.065 1000 -1000 -0.089 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0 15 27 -0.006 0.034 1000 -1000 -0.077 -1000
Rapid glucocorticoid signaling 0 3 20 0 0.017 1000 -1000 -0.052 -1000
Class IB PI3K non-lipid kinase events 0 0 3 -0.017 0.017 1000 -1000 -0.01 -1000
p38 MAPK signaling pathway 0 25 44 -0.012 0.064 1000 -1000 -0.088 -1000
Alternative NF-kappaB pathway 0 3 13 -0.002 0.017 1000 -1000 -0.085 -1000
Total 1676 97330 7203 -38 8.6 131000 -131000 -12 -131000
TCGA08_retinoblastoma

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B -0.48 0.25 -10000 0 -0.6 177 177
CDKN2C 0.034 0.048 -10000 0 -10000 0 0
CDKN2A -0.23 0.34 -10000 0 -0.74 70 70
CCND2 0.22 0.12 0.28 162 -10000 0 162
RB1 -0.23 0.12 -10000 0 -0.28 161 161
CDK4 0.23 0.12 0.28 164 -10000 0 164
CDK6 0.25 0.13 0.3 176 -10000 0 176
G1/S progression 0.23 0.12 0.28 165 -10000 0 165
Syndecan-1-mediated signaling events

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.017 0 -9999 0 -10000 0 0
CCL5 -0.14 0.28 -9999 0 -0.63 53 53
SDCBP 0.017 0 -9999 0 -10000 0 0
FGFR/FGF2/Syndecan-1 -0.42 0.14 -9999 0 -0.45 200 200
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
Syndecan-1/Laminin-5 -0.41 0.17 -9999 0 -0.44 200 200
Syndecan-1/Syntenin -0.39 0.13 -9999 0 -0.61 42 42
MAPK3 -0.35 0.13 -9999 0 -0.57 42 42
HGF/MET -0.25 0.27 -9999 0 -0.54 103 103
TGFB1/TGF beta receptor Type II 0.017 0 -9999 0 -10000 0 0
BSG 0.014 0.043 -9999 0 -0.63 1 1
keratinocyte migration -0.4 0.16 -9999 0 -0.44 200 200
Syndecan-1/RANTES -0.46 0.21 -9999 0 -0.71 76 76
Syndecan-1/CD147 -0.37 0.14 -9999 0 -0.6 45 45
Syndecan-1/Syntenin/PIP2 -0.37 0.13 -9999 0 -0.59 42 42
LAMA5 -0.026 0.17 -9999 0 -0.72 13 13
positive regulation of cell-cell adhesion -0.37 0.12 -9999 0 -0.57 42 42
MMP7 -0.7 0.12 -9999 0 -0.72 218 218
HGF 0.01 0.07 -9999 0 -0.72 2 2
Syndecan-1/CASK -0.4 0.13 -9999 0 -0.43 200 200
Syndecan-1/HGF/MET -0.54 0.22 -9999 0 -0.71 125 125
regulation of cell adhesion -0.33 0.13 -9999 0 -0.56 40 40
HPSE -0.085 0.24 -9999 0 -0.63 35 35
positive regulation of cell migration -0.42 0.14 -9999 0 -0.45 200 200
SDC1 -0.42 0.14 -9999 0 -0.45 200 200
Syndecan-1/Collagen -0.42 0.14 -9999 0 -0.45 200 200
PPIB 0.004 0.098 -9999 0 -0.72 4 4
MET -0.32 0.37 -9999 0 -0.72 101 101
PRKACA 0.017 0 -9999 0 -10000 0 0
MMP9 -0.006 0.13 -9999 0 -0.71 7 7
MAPK1 -0.35 0.13 -9999 0 -0.59 40 40
homophilic cell adhesion -0.41 0.13 -9999 0 -0.44 200 200
MMP1 -0.64 0.23 -9999 0 -0.72 199 199
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.24 0.18 -10000 0 -0.41 77 77
CRKL -0.26 0.19 -10000 0 -0.43 112 112
HRAS -0.2 0.18 -10000 0 -0.5 16 16
mol:PIP3 -0.26 0.18 -10000 0 -0.42 109 109
SPRED1 0.017 0 -10000 0 -10000 0 0
SPRED2 0.017 0 -10000 0 -10000 0 0
GAB1 -0.29 0.2 -10000 0 -0.46 113 113
FOXO3 -0.24 0.19 -10000 0 -0.42 81 81
AKT1 -0.27 0.2 -10000 0 -0.44 115 115
BAD -0.24 0.19 -10000 0 -0.42 81 81
megakaryocyte differentiation -0.33 0.24 -10000 0 -0.51 125 125
GSK3B -0.25 0.19 -10000 0 -0.42 81 81
RAF1 -0.16 0.15 -10000 0 -0.39 16 16
SHC1 0.017 0 -10000 0 -10000 0 0
STAT3 -0.28 0.2 -10000 0 -0.46 111 111
STAT1 -0.79 0.56 -10000 0 -1.3 113 113
HRAS/SPRED1 -0.18 0.12 -10000 0 -0.39 16 16
cell proliferation -0.28 0.2 -10000 0 -0.45 111 111
PIK3CA 0.016 0.001 -10000 0 -10000 0 0
TEC 0.017 0 -10000 0 -10000 0 0
RPS6KB1 -0.29 0.2 -10000 0 -0.46 112 112
HRAS/SPRED2 -0.18 0.12 -10000 0 -0.39 16 16
LYN/TEC/p62DOK -0.27 0.17 -10000 0 -0.42 99 99
MAPK3 -0.11 0.11 -10000 0 -0.3 1 1
STAP1 -0.48 0.28 -10000 0 -0.64 152 152
GRAP2 0.017 0 -10000 0 -10000 0 0
JAK2 -0.62 0.38 -10000 0 -0.97 112 112
STAT1 (dimer) -0.77 0.54 -10000 0 -1.2 113 113
mol:Gleevec 0.012 0.008 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.29 0.2 -10000 0 -0.47 107 107
actin filament polymerization -0.29 0.2 -10000 0 -0.46 111 111
LYN 0.017 0 -10000 0 -10000 0 0
STAP1/STAT5A (dimer) -0.59 0.34 -10000 0 -0.78 154 154
PIK3R1 0.016 0.001 -10000 0 -10000 0 0
CBL/CRKL/GRB2 -0.24 0.15 -10000 0 -0.51 4 4
PI3K -0.28 0.17 -10000 0 -0.44 101 101
PTEN 0 0.1 -10000 0 -0.63 6 6
SCF/KIT/EPO/EPOR -0.85 0.67 -10000 0 -1.5 111 111
MAPK8 -0.28 0.2 -10000 0 -0.46 111 111
STAT3 (dimer) -0.28 0.2 -10000 0 -0.45 111 111
positive regulation of transcription -0.086 0.096 -10000 0 -10000 0 0
mol:GDP -0.24 0.16 -10000 0 -0.56 16 16
PIK3C2B -0.29 0.2 -10000 0 -0.46 111 111
CBL/CRKL -0.24 0.18 -10000 0 -0.41 77 77
FER -0.3 0.21 -10000 0 -0.48 115 115
SH2B3 -0.28 0.2 -10000 0 -0.46 111 111
PDPK1 -0.23 0.17 -10000 0 -0.38 109 109
SNAI2 -0.3 0.22 -10000 0 -0.48 113 113
positive regulation of cell proliferation -0.52 0.35 -10000 0 -0.82 115 115
KITLG -0.002 0.068 -10000 0 -0.71 2 2
cell motility -0.52 0.35 -10000 0 -0.82 115 115
PTPN6 0.031 0.015 -10000 0 -10000 0 0
EPOR -0.23 0.17 -10000 0 -10000 0 0
STAT5A (dimer) -0.42 0.28 -10000 0 -0.66 114 114
SOCS1 0.014 0.049 -10000 0 -0.72 1 1
cell migration 0.28 0.2 0.45 111 -10000 0 111
SOS1 0.017 0 -10000 0 -10000 0 0
EPO 0.001 0.05 -10000 0 -0.74 1 1
VAV1 -0.041 0.18 -10000 0 -0.63 20 20
GRB10 -0.31 0.23 -10000 0 -0.49 117 117
PTPN11 0.023 0.052 -10000 0 -0.73 1 1
SCF/KIT -0.32 0.2 -10000 0 -0.5 111 111
GO:0007205 0.016 0.01 -10000 0 -10000 0 0
MAP2K1 -0.12 0.12 -10000 0 -10000 0 0
CBL 0.017 0 -10000 0 -10000 0 0
KIT -0.81 0.72 -10000 0 -1.5 111 111
MAP2K2 -0.12 0.12 -10000 0 -10000 0 0
SHC/Grb2/SOS1 -0.26 0.17 -10000 0 -0.42 102 102
STAT5A -0.44 0.3 -10000 0 -0.69 114 114
GRB2 0.017 0 -10000 0 -10000 0 0
response to radiation -0.29 0.21 -10000 0 -0.47 113 113
SHC/GRAP2 0 0 -10000 0 -10000 0 0
PTPRO -0.34 0.24 -10000 0 -0.52 125 125
SH2B2 -0.3 0.2 -10000 0 -0.47 111 111
DOK1 0.014 0.049 -10000 0 -0.72 1 1
MATK -0.28 0.2 -10000 0 -0.46 111 111
CREBBP 0.01 0.021 -10000 0 -10000 0 0
BCL2 -0.99 0.69 -10000 0 -1.5 147 147
FAS signaling pathway (CD95)

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 0.17 0.13 0.26 147 -0.33 1 148
RFC1 0.17 0.13 0.26 147 -0.33 1 148
PRKDC 0.13 0.19 0.26 133 -0.51 5 138
RIPK1 0.019 0.005 -10000 0 -10000 0 0
CASP7 -0.12 0.26 -10000 0 -0.73 33 33
FASLG/FAS/FADD/FAF1 -0.006 0.18 0.43 1 -0.43 14 15
MAP2K4 -0.068 0.17 -10000 0 -0.47 18 18
mol:ceramide -0.062 0.16 -10000 0 -0.52 13 13
GSN 0.1 0.19 0.26 117 -0.38 8 125
FASLG/FAS/FADD/FAF1/Caspase 8 -0.02 0.16 -10000 0 -0.5 12 12
FAS -0.054 0.19 -10000 0 -0.63 22 22
BID -0.013 0.086 -10000 0 -0.48 7 7
MAP3K1 -0.033 0.19 0.28 1 -0.55 20 21
MAP3K7 0.01 0.009 -10000 0 -10000 0 0
RB1 0.17 0.13 0.26 147 -0.33 1 148
CFLAR 0.019 0.005 -10000 0 -10000 0 0
HGF/MET -0.35 0.32 -10000 0 -0.57 136 136
ARHGDIB 0.17 0.13 0.26 146 -0.33 1 147
FADD 0.01 0.009 -10000 0 -10000 0 0
actin filament polymerization -0.1 0.19 0.37 8 -0.26 117 125
NFKB1 -0.076 0.07 -10000 0 -10000 0 0
MAPK8 -0.098 0.19 -10000 0 -0.6 9 9
DFFA 0.17 0.13 0.26 147 -0.33 1 148
DNA fragmentation during apoptosis 0.17 0.14 0.26 146 -0.39 2 148
FAS/FADD/MET -0.24 0.25 -10000 0 -0.48 113 113
CFLAR/RIP1 0 0 -10000 0 -10000 0 0
FAIM3 0.012 0.07 -10000 0 -0.72 2 2
FAF1 0.01 0.009 -10000 0 -10000 0 0
PARP1 0.17 0.13 0.26 147 -0.33 1 148
DFFB 0.17 0.14 0.26 146 -0.39 2 148
CHUK -0.062 0.059 -10000 0 -10000 0 0
FASLG -0.06 0.2 -10000 0 -0.64 24 24
FAS/FADD -0.045 0.14 -10000 0 -0.46 22 22
HGF 0.01 0.07 -10000 0 -0.72 2 2
LMNA 0.16 0.12 0.24 147 -10000 0 147
CASP6 0.17 0.13 0.26 147 -0.33 1 148
CASP10 0.01 0.009 -10000 0 -10000 0 0
CASP3 0.2 0.15 0.31 147 -0.38 1 148
PTPN13 -0.21 0.34 -10000 0 -0.72 70 70
CASP8 0.003 0.031 0.34 2 -10000 0 2
IL6 -0.23 0.29 -10000 0 -0.63 16 16
MET -0.32 0.37 -10000 0 -0.72 101 101
ICAD/CAD 0.16 0.13 0.34 2 -0.42 1 3
FASLG/FAS/FADD/FAF1/Caspase 10 -0.063 0.16 -10000 0 -0.53 13 13
activation of caspase activity by cytochrome c -0.013 0.085 -10000 0 -0.48 7 7
PAK2 0.17 0.13 0.26 147 -0.33 1 148
BCL2 -0.41 0.31 -10000 0 -0.63 147 147
BCR signaling pathway

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.19 0.28 -10000 0 -0.52 86 86
IKBKB -0.096 0.14 -10000 0 -0.28 28 28
AKT1 -0.094 0.17 0.24 2 -0.29 58 60
IKBKG -0.1 0.15 -10000 0 -0.3 29 29
CALM1 -0.32 0.34 -10000 0 -0.66 99 99
PIK3CA 0.017 0 -10000 0 -10000 0 0
MAP3K1 -0.28 0.4 -10000 0 -0.74 90 90
MAP3K7 0.017 0 -10000 0 -10000 0 0
mol:Ca2+ -0.35 0.37 -10000 0 -0.7 105 105
DOK1 0.014 0.049 -10000 0 -0.72 1 1
AP-1 -0.12 0.16 -10000 0 -0.3 81 81
LYN 0.017 0 -10000 0 -10000 0 0
BLNK 0 0.1 -10000 0 -0.63 6 6
SHC1 0.017 0 -10000 0 -10000 0 0
BCR complex -0.36 0.38 -10000 0 -0.72 114 114
CD22 -0.38 0.48 -10000 0 -0.93 87 87
CAMK2G -0.28 0.31 -10000 0 -0.6 99 99
CSNK2A1 0.017 0 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.24 0.26 -10000 0 -0.57 77 77
GO:0007205 -0.36 0.38 -10000 0 -0.72 105 105
SYK 0.014 0.049 -10000 0 -0.72 1 1
ELK1 -0.33 0.35 -10000 0 -0.67 103 103
NFATC1 -0.29 0.38 -10000 0 -0.69 98 98
B-cell antigen/BCR complex -0.36 0.38 -10000 0 -0.72 114 114
PAG1/CSK -0.13 0.21 -10000 0 -0.46 65 65
NFKBIB -0.019 0.049 -10000 0 -10000 0 0
HRAS -0.28 0.32 -10000 0 -0.62 99 99
NFKBIA -0.018 0.048 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B beta -0.005 0.039 -10000 0 -10000 0 0
RasGAP/Csk -0.34 0.37 -10000 0 -0.79 84 84
mol:GDP -0.33 0.35 -10000 0 -0.68 104 104
PTEN -0.001 0.1 -10000 0 -0.63 6 6
CD79B -0.23 0.32 -10000 0 -0.63 85 85
NF-kappa-B/RelA/I kappa B alpha -0.004 0.039 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.31 0.37 -10000 0 -0.68 107 107
PIK3R1 0.017 0 -10000 0 -10000 0 0
mol:IP3 -0.36 0.39 -10000 0 -0.73 105 105
CSK 0.017 0 -10000 0 -10000 0 0
FOS -0.33 0.35 -10000 0 -0.66 108 108
CHUK -0.1 0.15 -10000 0 -0.3 28 28
IBTK 0.017 0 -10000 0 -10000 0 0
CARD11/BCL10/MALT1/TAK1 -0.29 0.28 -10000 0 -0.63 80 80
PTPN6 -0.35 0.44 -10000 0 -0.88 84 84
RELA 0.017 0 -10000 0 -10000 0 0
BCL2A1 -0.004 0.039 -10000 0 -0.12 8 8
VAV2 -0.45 0.52 -10000 0 -0.99 100 100
ubiquitin-dependent protein catabolic process -0.012 0.047 -10000 0 -10000 0 0
BTK -0.18 0.44 -10000 0 -1.2 35 35
CD19 -0.48 0.56 -10000 0 -1.1 100 100
MAP4K1 0.017 0 -10000 0 -10000 0 0
CD72 0.005 0.092 -10000 0 -0.68 4 4
PAG1 -0.17 0.3 -10000 0 -0.63 65 65
MAPK14 -0.22 0.33 -10000 0 -0.6 86 86
SH3BP5 0.014 0.043 -10000 0 -0.63 1 1
PIK3AP1 -0.36 0.39 -10000 0 -0.76 99 99
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.42 0.45 -10000 0 -0.87 100 100
RAF1 -0.26 0.3 -10000 0 -0.57 98 98
RasGAP/p62DOK/SHIP -0.34 0.36 -10000 0 -0.76 85 85
CD79A -0.28 0.32 -10000 0 -0.63 104 104
re-entry into mitotic cell cycle -0.12 0.16 -10000 0 -0.3 82 82
RASA1 0.01 0.07 -10000 0 -0.72 2 2
MAPK3 -0.19 0.25 -10000 0 -0.51 69 69
MAPK1 -0.19 0.24 -10000 0 -0.51 69 69
CD72/SHP1 -0.3 0.42 -10000 0 -0.8 84 84
NFKB1 0.017 0 -10000 0 -10000 0 0
MAPK8 -0.22 0.33 -10000 0 -0.6 83 83
actin cytoskeleton organization -0.32 0.42 -10000 0 -0.76 100 100
NF-kappa-B/RelA -0.002 0.076 -10000 0 -10000 0 0
Calcineurin -0.26 0.26 -10000 0 -0.6 72 72
PI3K -0.29 0.31 -10000 0 -0.64 94 94
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.4 0.4 -10000 0 -0.8 102 102
SOS1 0.017 0 -10000 0 -10000 0 0
Bam32/HPK1 -0.33 0.44 -10000 0 -0.85 86 86
DAPP1 -0.41 0.5 -10000 0 -0.99 88 88
cytokine secretion -0.26 0.34 -10000 0 -0.62 98 98
mol:DAG -0.36 0.39 -10000 0 -0.73 105 105
PLCG2 -0.3 0.32 -10000 0 -0.63 111 111
MAP2K1 -0.22 0.27 -10000 0 -0.55 81 81
B-cell antigen/BCR complex/FcgammaRIIB -0.4 0.42 -10000 0 -0.74 119 119
mol:PI-3-4-5-P3 -0.19 0.2 0.33 2 -0.42 85 87
ETS1 -0.24 0.28 -10000 0 -0.6 70 70
B-cell antigen/BCR complex/LYN/SYK/BLNK -0.28 0.3 -10000 0 -0.67 77 77
B-cell antigen/BCR complex/LYN -0.41 0.51 -10000 0 -0.98 91 91
MALT1 0.017 0 -10000 0 -10000 0 0
TRAF6 0.017 0 -10000 0 -10000 0 0
RAC1 -0.36 0.46 -10000 0 -0.84 100 100
B-cell antigen/BCR complex/LYN/SYK -0.36 0.41 -10000 0 -0.89 78 78
CARD11 -0.35 0.37 -10000 0 -0.7 107 107
FCGR2B -0.13 0.27 -10000 0 -0.63 50 50
PPP3CA 0.017 0 -10000 0 -10000 0 0
BCL10 0.017 0 -10000 0 -10000 0 0
IKK complex -0.023 0.062 -10000 0 -10000 0 0
PTPRC -0.018 0.15 -10000 0 -0.63 12 12
PDPK1 -0.089 0.17 0.23 2 -0.28 59 61
PPP3CB 0.017 0 -10000 0 -10000 0 0
PPP3CC 0.002 0.096 -10000 0 -0.63 5 5
POU2F2 0.004 0.029 -10000 0 -10000 0 0
FOXM1 transcription factor network

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 -0.46 0.54 -9999 0 -1.2 57 57
PLK1 0.013 0.054 -9999 0 -10000 0 0
BIRC5 -0.047 0.2 -9999 0 -0.61 23 23
HSPA1B -0.47 0.54 -9999 0 -1.1 73 73
MAP2K1 0.007 0.032 -9999 0 -10000 0 0
BRCA2 -0.55 0.58 -9999 0 -1.2 78 78
FOXM1 -0.63 0.76 -9999 0 -1.6 71 71
XRCC1 -0.46 0.54 -9999 0 -1.1 62 62
FOXM1B/p19 -0.68 0.57 -9999 0 -1.3 91 91
Cyclin D1/CDK4 -0.5 0.52 -9999 0 -1.1 76 76
CDC2 -0.5 0.59 -9999 0 -1.2 69 69
TGFA -0.45 0.49 -9999 0 -1 68 68
SKP2 -0.48 0.56 -9999 0 -1.2 61 61
CCNE1 -0.041 0.19 -9999 0 -0.74 15 15
CKS1B -0.46 0.55 -9999 0 -1.2 58 58
RB1 -0.25 0.22 -9999 0 -0.65 34 34
FOXM1C/SP1 -0.62 0.67 -9999 0 -1.4 77 77
AURKB 0.013 0.054 -9999 0 -10000 0 0
CENPF -0.46 0.55 -9999 0 -1.2 60 60
CDK4 -0.052 0.2 -9999 0 -0.74 18 18
MYC -0.61 0.5 -9999 0 -1.1 91 91
CHEK2 0.007 0.032 -9999 0 -10000 0 0
ONECUT1 -0.5 0.54 -9999 0 -1.1 73 73
CDKN2A -0.22 0.34 -9999 0 -0.73 70 70
LAMA4 -0.46 0.54 -9999 0 -1.2 58 58
FOXM1B/HNF6 -0.6 0.67 -9999 0 -1.4 77 77
FOS -0.53 0.6 -9999 0 -1.2 78 78
SP1 0.011 0.013 -9999 0 -10000 0 0
CDC25B -0.57 0.58 -9999 0 -1.2 81 81
response to radiation -0.016 0.032 -9999 0 -10000 0 0
CENPB -0.46 0.54 -9999 0 -1.2 58 58
CENPA -0.5 0.59 -9999 0 -1.2 68 68
NEK2 -0.56 0.6 -9999 0 -1.2 79 79
HIST1H2BA -0.46 0.54 -9999 0 -1.2 58 58
CCNA2 -0.1 0.26 -9999 0 -0.74 33 33
EP300 0.017 0 -9999 0 -10000 0 0
CCNB1/CDK1 -0.57 0.67 -9999 0 -1.4 67 67
CCNB2 -0.46 0.54 -9999 0 -1.2 58 58
CCNB1 -0.52 0.6 -9999 0 -1.3 69 69
ETV5 -0.48 0.56 -9999 0 -1.2 70 70
ESR1 -0.46 0.55 -9999 0 -1.2 61 61
CCND1 -0.5 0.52 -9999 0 -1.1 73 73
GSK3A 0.011 0.025 -9999 0 -10000 0 0
Cyclin A-E1/CDK1-2 -0.14 0.3 -9999 0 -0.61 56 56
CDK2 -0.074 0.23 -9999 0 -0.73 25 25
G2/M transition of mitotic cell cycle -0.02 0.039 -9999 0 -10000 0 0
FOXM1B/Cbp/p300 -0.55 0.54 -9999 0 -1.2 80 80
GAS1 -0.64 0.65 -9999 0 -1.3 99 99
MMP2 -0.46 0.54 -9999 0 -1.2 60 60
RB1/FOXM1C -0.51 0.55 -9999 0 -1.1 75 75
CREBBP 0.017 0 -9999 0 -10000 0 0
Fc-epsilon receptor I signaling in mast cells

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A -0.041 0.18 -9999 0 -0.63 20 20
LAT2 -0.24 0.23 -9999 0 -0.49 88 88
AP1 -0.31 0.29 -9999 0 -0.57 103 103
mol:PIP3 -0.3 0.3 -9999 0 -0.6 93 93
IKBKB -0.14 0.16 -9999 0 -0.32 49 49
AKT1 -0.22 0.24 -9999 0 -0.64 4 4
IKBKG -0.14 0.16 -9999 0 -0.32 48 48
MS4A2 -0.39 0.32 -9999 0 -0.64 138 138
mol:Sphingosine-1-phosphate 0 0 -9999 0 -10000 0 0
PIK3CA 0.015 0.002 -9999 0 -10000 0 0
MAP3K1 -0.2 0.24 -9999 0 -0.56 42 42
mol:Ca2+ -0.21 0.22 -9999 0 -0.43 93 93
LYN 0.007 0.009 -9999 0 -10000 0 0
CBLB -0.23 0.23 -9999 0 -0.48 88 88
SHC1 0.017 0 -9999 0 -10000 0 0
RasGAP/p62DOK -0.035 0.11 -9999 0 -0.62 2 2
positive regulation of cell migration -0.013 0.11 -9999 0 -0.47 13 13
INPP5D 0 0 -9999 0 -10000 0 0
PLD2 -0.29 0.28 -9999 0 -0.6 88 88
PTPN13 -0.34 0.29 -9999 0 -0.59 111 111
PTPN11 0.006 0.051 -9999 0 -0.75 1 1
GO:0007205 0 0 -9999 0 -10000 0 0
regulation of mast cell degranulation -0.16 0.2 -9999 0 -0.38 19 19
SYK 0.004 0.05 -9999 0 -0.73 1 1
GRB2 0.016 0.001 -9999 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.34 0.28 -9999 0 -0.62 100 100
LAT -0.24 0.24 -9999 0 -0.49 88 88
PAK2 -0.24 0.28 -9999 0 -0.51 97 97
NFATC2 -0.1 0.078 -9999 0 -10000 0 0
HRAS -0.28 0.3 -9999 0 -0.57 97 97
GAB2 0.017 0 -9999 0 -10000 0 0
PLA2G1B 0.064 0.028 -9999 0 -10000 0 0
Fc epsilon R1 -0.4 0.31 -9999 0 -0.74 89 89
Antigen/IgE/Fc epsilon R1 -0.36 0.29 -9999 0 -0.68 89 89
mol:GDP -0.3 0.33 -9999 0 -0.62 97 97
JUN 0 0.11 -9999 0 -0.72 5 5
mol:Ca++ 0 0 -9999 0 -10000 0 0
PIK3R1 0.015 0.002 -9999 0 -10000 0 0
FOS -0.08 0.23 -9999 0 -0.64 33 33
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.27 0.22 -9999 0 -0.51 89 89
CHUK -0.14 0.16 -9999 0 -0.32 48 48
KLRG1 -0.22 0.22 -9999 0 -0.46 88 88
VAV1 -0.26 0.27 -9999 0 -0.54 90 90
calcium-dependent protein kinase C activity 0 0 -9999 0 -10000 0 0
CBL -0.23 0.23 -9999 0 -0.48 88 88
negative regulation of mast cell degranulation -0.22 0.18 -9999 0 -0.42 88 88
BTK -0.34 0.34 -9999 0 -0.66 96 96
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.42 0.42 -9999 0 -0.85 98 98
GAB2/PI3K/SHP2 -0.27 0.23 -9999 0 -0.54 88 88
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.28 0.28 -9999 0 -0.59 88 88
RAF1 0.053 0.033 -9999 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP -0.41 0.35 -9999 0 -0.77 96 96
FCER1G 0.026 0.011 -9999 0 -10000 0 0
FCER1A -0.29 0.33 -9999 0 -0.65 102 102
Antigen/IgE/Fc epsilon R1/Fyn -0.34 0.27 -9999 0 -0.64 88 88
MAPK3 0.062 0.03 -9999 0 -10000 0 0
MAPK1 0.062 0.029 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
MAPK8 -0.056 0.12 -9999 0 -0.66 4 4
DUSP1 -0.038 0.18 -9999 0 -0.63 19 19
NF-kappa-B/RelA -0.095 0.072 -9999 0 -10000 0 0
actin cytoskeleton reorganization -0.24 0.24 -9999 0 -0.49 88 88
mol:Glucocorticoid Dexamethasone 0 0 -9999 0 -10000 0 0
PI3K -0.27 0.24 -9999 0 -0.52 84 84
FER -0.25 0.24 -9999 0 -0.49 93 93
RELA 0.017 0 -9999 0 -10000 0 0
ITK -0.057 0.044 -9999 0 -10000 0 0
SOS1 0.017 0 -9999 0 -10000 0 0
PLCG1 -0.32 0.35 -9999 0 -0.64 100 100
cytokine secretion -0.069 0.052 -9999 0 -10000 0 0
SPHK1 -0.28 0.25 -9999 0 -0.52 98 98
PTK2 -0.26 0.24 -9999 0 -0.51 88 88
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.36 0.29 -9999 0 -0.66 93 93
EDG1 -0.013 0.11 -9999 0 -0.47 13 13
mol:DAG -0.3 0.31 -9999 0 -0.6 96 96
MAP2K2 0.058 0.029 -9999 0 -10000 0 0
MAP2K1 0.058 0.029 -9999 0 -10000 0 0
MAP2K7 0.017 0 -9999 0 -10000 0 0
KLRG1/SHP2 -0.21 0.18 -9999 0 -0.41 88 88
MAP2K4 -0.006 0.14 -9999 0 -1 4 4
Fc epsilon R1/FcgammaRIIB -0.43 0.37 -9999 0 -0.81 96 96
mol:Choline -0.29 0.27 -9999 0 -0.59 88 88
SHC/Grb2/SOS1 -0.23 0.19 -9999 0 -0.44 88 88
FYN 0.014 0.043 -9999 0 -0.63 1 1
DOK1 0.014 0.049 -9999 0 -0.72 1 1
PXN -0.23 0.23 -9999 0 -0.47 88 88
HCLS1 -0.25 0.26 -9999 0 -0.52 88 88
PRKCB -0.21 0.22 -9999 0 -0.43 93 93
FCGR2B -0.13 0.27 -9999 0 -0.63 50 50
IGHE -0.007 0.008 -9999 0 -10000 0 0
KLRG1/SHIP -0.23 0.19 -9999 0 -0.43 88 88
LCP2 0.003 0.095 -9999 0 -0.7 4 4
PLA2G4A -0.33 0.29 -9999 0 -0.57 115 115
RASA1 0.01 0.07 -9999 0 -0.72 2 2
mol:Phosphatidic acid -0.29 0.27 -9999 0 -0.59 88 88
IKK complex -0.09 0.13 -9999 0 -0.27 1 1
WIPF1 0.014 0.043 -9999 0 -0.63 1 1
Glypican 1 network

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer -0.032 0.11 -10000 0 -0.42 17 17
fibroblast growth factor receptor signaling pathway -0.032 0.11 -10000 0 -0.42 17 17
LAMA1 0.017 0 -10000 0 -10000 0 0
PRNP 0.017 0 -10000 0 -10000 0 0
GPC1/SLIT2 -0.28 0.24 -10000 0 -0.47 132 132
SMAD2 0.03 0.084 -10000 0 -0.41 8 8
GPC1/PrPc/Cu2+ -0.017 0.087 -10000 0 -0.47 8 8
GPC1/Laminin alpha1 -0.019 0.1 -10000 0 -0.54 8 8
TDGF1 -0.48 0.35 -10000 0 -0.72 150 150
CRIPTO/GPC1 -0.38 0.26 -10000 0 -0.55 153 153
APP/GPC1 -0.019 0.1 -10000 0 -0.54 8 8
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.31 0.24 -10000 0 -0.47 153 153
FLT1 -0.019 0.16 -10000 0 -0.72 11 11
GPC1/TGFB/TGFBR1/TGFBR2 -0.016 0.085 -10000 0 -0.46 8 8
SERPINC1 0.014 0.049 -10000 0 -0.72 1 1
FYN -0.31 0.24 -10000 0 -0.47 154 154
FGR -0.31 0.24 -10000 0 -0.47 153 153
positive regulation of MAPKKK cascade -0.26 0.22 -10000 0 -0.53 55 55
SLIT2 -0.35 0.32 -10000 0 -0.63 126 126
GPC1/NRG -0.019 0.1 -10000 0 -0.54 8 8
NRG1 0.017 0 -10000 0 -10000 0 0
GPC1/VEGF165 homodimer/VEGFR1 homodimer -0.081 0.2 -10000 0 -0.53 34 34
LYN -0.31 0.24 -10000 0 -0.47 153 153
mol:Spermine -0.005 0.1 -10000 0 -0.55 8 8
cell growth -0.032 0.11 -10000 0 -0.42 17 17
BMP signaling pathway 0.009 0.14 0.72 8 -10000 0 8
SRC -0.31 0.24 -10000 0 -0.47 153 153
TGFBR1 0.017 0 -10000 0 -10000 0 0
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.12 0.28 -10000 0 -0.66 46 46
GPC1 -0.009 0.14 -10000 0 -0.72 8 8
TGFBR1 (dimer) 0.017 0 -10000 0 -10000 0 0
VEGFA -0.052 0.22 -10000 0 -0.72 21 21
BLK -0.41 0.31 -10000 0 -0.56 169 169
HCK -0.34 0.27 -10000 0 -0.5 159 159
FGF2 -0.01 0.13 -10000 0 -0.64 9 9
FGFR1 0.017 0 -10000 0 -10000 0 0
VEGFR1 homodimer -0.019 0.16 -10000 0 -0.72 11 11
TGFBR2 0.017 0 -10000 0 -10000 0 0
cell death -0.019 0.1 -10000 0 -0.54 8 8
ATIII/GPC1 -0.022 0.11 -10000 0 -0.54 9 9
PLA2G2A/GPC1 -0.12 0.22 -10000 0 -0.52 51 51
LCK -0.31 0.24 -10000 0 -0.47 154 154
neuron differentiation -0.019 0.1 -10000 0 -0.54 8 8
PrPc/Cu2+ 0 0 -10000 0 -10000 0 0
APP 0.017 0 -10000 0 -10000 0 0
TGFBR2 (dimer) 0.017 0 -10000 0 -10000 0 0
HIF-1-alpha transcription factor network

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.54 0.45 -9999 0 -1.1 57 57
HDAC7 -0.003 0.011 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.38 0.29 -9999 0 -0.86 32 32
SMAD4 0.01 0.074 -9999 0 -0.63 3 3
ID2 -0.53 0.45 -9999 0 -1.1 56 56
AP1 -0.08 0.18 -9999 0 -0.48 37 37
ABCG2 -0.82 0.45 -9999 0 -1.2 100 100
HIF1A -0.075 0.09 -9999 0 -0.87 2 2
TFF3 -0.54 0.45 -9999 0 -1.1 57 57
GATA2 0.018 0.005 -9999 0 -10000 0 0
AKT1 -0.059 0.058 -9999 0 -10000 0 0
response to hypoxia -0.089 0.064 -9999 0 -10000 0 0
MCL1 -0.53 0.44 -9999 0 -1.1 56 56
NDRG1 -0.58 0.48 -9999 0 -1.2 66 66
SERPINE1 -0.6 0.49 -9999 0 -1.2 66 66
FECH -0.53 0.44 -9999 0 -1.1 56 56
FURIN -0.53 0.44 -9999 0 -1.1 56 56
NCOA2 0.019 0.002 -9999 0 -10000 0 0
EP300 -0.053 0.078 -9999 0 -10000 0 0
HMOX1 -0.57 0.48 -9999 0 -1.2 63 63
BHLHE40 -0.54 0.44 -9999 0 -1.1 57 57
BHLHE41 -0.54 0.44 -9999 0 -1.1 57 57
HIF1A/ARNT/SMAD3/SMAD4/SP1 -0.072 0.084 -9999 0 -0.54 3 3
ENG -0.039 0.1 -9999 0 -0.53 1 1
JUN 0.001 0.11 -9999 0 -0.72 5 5
RORA -0.54 0.45 -9999 0 -1.2 56 56
ABCB1 -0.6 0.63 -9999 0 -1.3 94 94
TFRC -0.54 0.46 -9999 0 -1.2 57 57
CXCR4 -0.55 0.46 -9999 0 -1.2 57 57
TF -0.53 0.44 -9999 0 -1.1 56 56
CITED2 -0.53 0.44 -9999 0 -1.1 56 56
HIF1A/ARNT -0.63 0.53 -9999 0 -1.3 60 60
LDHA -0.047 0.042 -9999 0 -10000 0 0
ETS1 -0.53 0.44 -9999 0 -1.1 56 56
PGK1 -0.55 0.46 -9999 0 -1.2 58 58
NOS2 -0.54 0.44 -9999 0 -1.1 57 57
ITGB2 -0.54 0.45 -9999 0 -1.1 57 57
ALDOA -0.53 0.44 -9999 0 -1.1 56 56
Cbp/p300/CITED2 -0.52 0.43 -9999 0 -1.2 47 47
FOS -0.079 0.23 -9999 0 -0.64 33 33
HK2 -0.53 0.44 -9999 0 -1.1 56 56
SP1 0.007 0.039 -9999 0 -10000 0 0
GCK -0.072 0.11 -9999 0 -10000 0 0
HK1 -0.53 0.44 -9999 0 -1.1 56 56
NPM1 -0.53 0.45 -9999 0 -1.1 56 56
EGLN1 -0.53 0.44 -9999 0 -1.1 56 56
CREB1 0.028 0 -9999 0 -10000 0 0
PGM1 -0.58 0.47 -9999 0 -1.2 64 64
SMAD3 0.013 0.061 -9999 0 -0.63 2 2
EDN1 -0.098 0.3 -9999 0 -1.3 11 11
IGFBP1 -0.56 0.48 -9999 0 -1.2 61 61
VEGFA -0.37 0.34 -9999 0 -1 26 26
HIF1A/JAB1 -0.034 0.066 -9999 0 -0.67 2 2
CP -0.59 0.49 -9999 0 -1.2 66 66
CXCL12 -0.77 0.48 -9999 0 -1.2 98 98
COPS5 0.019 0.001 -9999 0 -10000 0 0
SMAD3/SMAD4 -0.01 0.067 -9999 0 -0.45 5 5
BNIP3 -0.58 0.48 -9999 0 -1.2 63 63
EGLN3 -0.65 0.51 -9999 0 -1.2 77 77
CA9 -0.7 0.48 -9999 0 -1.2 79 79
TERT -0.53 0.44 -9999 0 -1.1 56 56
ENO1 -0.53 0.45 -9999 0 -1.2 56 56
PFKL -0.53 0.44 -9999 0 -1.1 56 56
NCOA1 0.011 0.061 -9999 0 -0.63 2 2
ADM -0.53 0.45 -9999 0 -1.1 56 56
ARNT -0.068 0.049 -9999 0 -10000 0 0
HNF4A 0.023 0 -9999 0 -10000 0 0
ADFP -0.55 0.46 -9999 0 -1.2 61 61
SLC2A1 -0.38 0.34 -9999 0 -0.98 30 30
LEP -0.53 0.44 -9999 0 -1.1 56 56
HIF1A/ARNT/Cbp/p300 -0.4 0.3 -9999 0 -0.87 38 38
EPO -0.24 0.22 -9999 0 -0.82 2 2
CREBBP -0.053 0.078 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/HDAC7 -0.41 0.33 -9999 0 -0.91 43 43
PFKFB3 -0.55 0.47 -9999 0 -1.2 60 60
NT5E -0.55 0.46 -9999 0 -1.2 57 57
Reelin signaling pathway

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 -0.005 0.051 -9999 0 -0.54 2 2
VLDLR -0.12 0.27 -9999 0 -0.63 48 48
CRKL 0.017 0 -9999 0 -10000 0 0
LRPAP1 0.017 0 -9999 0 -10000 0 0
FYN 0.014 0.043 -9999 0 -0.63 1 1
ITGA3 0.014 0.049 -9999 0 -0.72 1 1
RELN/VLDLR/Fyn -0.084 0.16 -9999 0 -0.39 48 48
MAPK8IP1/MKK7/MAP3K11/JNK1 -0.003 0.035 -9999 0 -10000 0 0
AKT1 -0.01 0.12 -9999 0 -10000 0 0
MAP2K7 0.017 0 -9999 0 -10000 0 0
RAPGEF1 0.017 0 -9999 0 -10000 0 0
DAB1 0.017 0 -9999 0 -10000 0 0
RELN/LRP8/DAB1 -0.37 0.14 -9999 0 -0.42 197 197
LRPAP1/LRP8 -0.47 0.18 -9999 0 -0.54 197 197
RELN/LRP8/DAB1/Fyn -0.34 0.13 -9999 0 -0.39 197 197
DAB1/alpha3/beta1 Integrin -0.36 0.17 -9999 0 -0.65 44 44
long-term memory -0.37 0.18 -9999 0 -0.74 30 30
DAB1/LIS1 -0.38 0.18 -9999 0 -0.67 43 43
DAB1/CRLK/C3G -0.36 0.17 -9999 0 -0.65 43 43
PIK3CA 0.017 0 -9999 0 -10000 0 0
DAB1/NCK2 -0.38 0.18 -9999 0 -0.68 43 43
ARHGEF2 0.014 0.049 -9999 0 -0.72 1 1
mol:Src family inhibitors PP1 and PP2 0 0 -9999 0 -10000 0 0
GRIN2A 0.017 0 -9999 0 -10000 0 0
CDK5R1 0.017 0 -9999 0 -10000 0 0
RELN 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
RELN/LRP8/Fyn -0.4 0.15 -9999 0 -0.46 197 197
GRIN2A/RELN/LRP8/DAB1/Fyn -0.33 0.12 -9999 0 -0.71 1 1
MAPK8 0.017 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1 -0.075 0.14 -9999 0 -0.42 1 1
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
MAP1B -0.38 0.22 -9999 0 -0.71 53 53
RELN/LRP8 -0.4 0.15 -9999 0 -0.46 197 197
GRIN2B/RELN/LRP8/DAB1/Fyn -0.39 0.19 -9999 0 -0.77 30 30
PI3K 0 0 -9999 0 -10000 0 0
mol:PP2 0 0 -9999 0 -10000 0 0
alpha3/beta1 Integrin -0.005 0.051 -9999 0 -0.54 2 2
RAP1A -0.32 0.18 -9999 0 -0.6 43 43
PAFAH1B1 0.017 0 -9999 0 -10000 0 0
MAPK8IP1 0.014 0.049 -9999 0 -0.72 1 1
CRLK/C3G 0 0 -9999 0 -10000 0 0
GRIN2B -0.089 0.26 -9999 0 -0.72 32 32
NCK2 0.017 0 -9999 0 -10000 0 0
neuron differentiation -0.12 0.07 -9999 0 -0.36 2 2
neuron adhesion -0.3 0.17 -9999 0 -0.56 44 44
LRP8 -0.63 0.24 -9999 0 -0.72 197 197
GSK3B 0 0.12 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/Fyn -0.07 0.14 -9999 0 -0.52 2 2
MAP3K11 0.017 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/P13K -0.023 0.12 -9999 0 -10000 0 0
CDK5 0.01 0.07 -9999 0 -0.72 2 2
MAPT 0.014 0.026 -9999 0 -10000 0 0
neuron migration -0.25 0.16 -9999 0 -0.5 43 43
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.12 0.07 -9999 0 -0.36 2 2
RELN/VLDLR -0.43 0.2 -9999 0 -0.48 197 197
IL23-mediated signaling events

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.46 0.49 -10000 0 -1.1 56 56
IL23A -0.58 0.52 -10000 0 -1.3 61 61
NF kappa B1 p50/RelA/I kappa B alpha -0.48 0.45 -10000 0 -1.1 64 64
positive regulation of T cell mediated cytotoxicity -0.49 0.51 -10000 0 -1.2 63 63
ITGA3 -0.46 0.45 -10000 0 -1.1 52 52
IL17F -0.27 0.31 -10000 0 -0.73 35 35
IL12B 0.004 0.077 -10000 0 -0.77 2 2
STAT1 (dimer) -0.49 0.52 -10000 0 -1.2 64 64
CD4 -0.42 0.44 -10000 0 -1.1 46 46
IL23 -0.57 0.48 -10000 0 -1.2 60 60
IL23R -0.078 0.24 -10000 0 -1.6 5 5
IL1B -0.55 0.52 -10000 0 -1.3 61 61
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.44 0.47 -10000 0 -1.1 49 49
TYK2 0.006 0.014 -10000 0 -10000 0 0
STAT4 0.014 0.043 -10000 0 -0.63 1 1
STAT3 0.017 0.001 -10000 0 -10000 0 0
IL18RAP -0.11 0.25 -10000 0 -0.63 43 43
IL12RB1 0.006 0.014 -10000 0 -10000 0 0
PIK3CA 0.017 0.001 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 -0.001 0.017 -10000 0 -10000 0 0
IL23R/JAK2 -0.091 0.25 -10000 0 -1.1 9 9
positive regulation of chronic inflammatory response -0.49 0.51 -10000 0 -1.2 63 63
natural killer cell activation 0.006 0.013 0.078 5 -10000 0 5
JAK2 -0.003 0.11 -10000 0 -0.77 4 4
PIK3R1 0.017 0.001 -10000 0 -10000 0 0
NFKB1 0.013 0.003 -10000 0 -10000 0 0
RELA 0.013 0.003 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.54 0.45 -10000 0 -1.1 60 60
ALOX12B -0.42 0.44 -10000 0 -1.1 46 46
CXCL1 -0.63 0.48 -10000 0 -1.2 78 78
T cell proliferation -0.49 0.51 -10000 0 -1.2 63 63
NFKBIA 0.013 0.003 -10000 0 -10000 0 0
IL17A -0.21 0.25 -10000 0 -0.6 13 13
PI3K -0.44 0.45 -10000 0 -1 63 63
IFNG -0.038 0.048 0.16 2 -0.12 2 4
STAT3 (dimer) -0.41 0.43 -10000 0 -0.98 63 63
IL18R1 0.012 0.044 -10000 0 -0.63 1 1
IL23/IL23R/JAK2/TYK2/SOCS3 -0.24 0.26 -10000 0 -0.78 15 15
IL18/IL18R -0.093 0.22 -10000 0 -0.61 15 15
macrophage activation -0.031 0.017 -10000 0 -0.045 39 39
TNF -0.51 0.48 -10000 0 -1.1 60 60
STAT3/STAT4 -0.45 0.44 -10000 0 -1 64 64
STAT4 (dimer) -0.46 0.49 -10000 0 -1.1 63 63
IL18 -0.058 0.2 -10000 0 -0.64 25 25
IL19 -0.43 0.45 -10000 0 -1.1 47 47
STAT5A (dimer) -0.46 0.49 -10000 0 -1.1 63 63
STAT1 -0.049 0.21 -10000 0 -0.72 20 20
SOCS3 -0.013 0.14 -10000 0 -0.72 9 9
CXCL9 -0.52 0.52 -10000 0 -1.2 70 70
MPO -0.44 0.45 -10000 0 -1.1 50 50
positive regulation of humoral immune response -0.49 0.51 -10000 0 -1.2 63 63
IL23/IL23R/JAK2/TYK2 -0.52 0.56 -10000 0 -1.2 63 63
IL6 -0.57 0.52 -10000 0 -1.2 71 71
STAT5A 0.017 0 -10000 0 -10000 0 0
IL2 0.018 0.011 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0.006 0.013 0.078 5 -10000 0 5
CD3E -0.42 0.44 -10000 0 -1.1 46 46
keratinocyte proliferation -0.49 0.51 -10000 0 -1.2 63 63
NOS2 -0.43 0.44 -10000 0 -0.99 64 64
Endothelins

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.001 0.28 -10000 0 -0.56 25 25
PTK2B 0.017 0.001 -10000 0 -10000 0 0
mol:Ca2+ 0.04 0.18 -10000 0 -0.92 3 3
EDN1 0.074 0.19 -10000 0 -0.62 13 13
EDN3 -0.32 0.32 -10000 0 -0.63 118 118
EDN2 -0.49 0.27 -10000 0 -0.63 175 175
HRAS/GDP -0.061 0.19 -10000 0 -0.51 14 14
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.016 0.16 -10000 0 -0.36 16 16
ADCY4 -0.02 0.21 -10000 0 -0.47 23 23
ADCY5 -0.019 0.21 -10000 0 -0.47 23 23
ADCY6 -0.019 0.21 -10000 0 -0.47 23 23
ADCY7 -0.019 0.21 -10000 0 -0.46 24 24
ADCY1 -0.019 0.21 -10000 0 -0.47 23 23
ADCY2 -0.021 0.21 -10000 0 -0.47 23 23
ADCY3 -0.042 0.23 -10000 0 -0.5 31 31
ADCY8 -0.021 0.21 -10000 0 -0.47 23 23
ADCY9 -0.023 0.21 -10000 0 -0.46 27 27
arachidonic acid secretion -0.094 0.25 -10000 0 -0.61 29 29
ETB receptor/Endothelin-1/Gq/GTP -0.005 0.17 -10000 0 -0.47 16 16
GNAO1 0.017 0 -10000 0 -10000 0 0
HRAS 0.015 0.006 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP 0.083 0.32 0.34 119 -0.52 24 143
ETA receptor/Endothelin-1/Gs/GTP 0.076 0.3 0.31 119 -0.49 25 144
mol:GTP 0.001 0.005 -10000 0 -10000 0 0
COL3A1 -0.006 0.29 -10000 0 -0.61 24 24
EDNRB -0.046 0.18 -10000 0 -0.64 18 18
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 0 0.27 -10000 0 -0.56 23 23
CYSLTR1 -0.005 0.28 -10000 0 -0.57 26 26
SLC9A1 0.03 0.15 -10000 0 -0.34 4 4
mol:GDP -0.075 0.2 -10000 0 -0.52 17 17
SLC9A3 -0.38 0.36 -10000 0 -0.59 140 140
RAF1 -0.074 0.21 -10000 0 -0.5 26 26
JUN 0.043 0.17 -10000 0 -0.7 1 1
JAK2 -0.01 0.28 -10000 0 -0.55 30 30
mol:IP3 -0.038 0.17 -10000 0 -0.45 12 12
ETA receptor/Endothelin-1 0.082 0.39 0.39 119 -0.58 36 155
PLCB1 -0.2 0.34 -10000 0 -0.72 65 65
PLCB2 0.015 0.006 -10000 0 -10000 0 0
ETA receptor/Endothelin-3 -0.3 0.34 -10000 0 -0.53 140 140
FOS -0.13 0.37 -10000 0 -0.95 34 34
Gai/GDP -0.003 0.1 -10000 0 -10000 0 0
CRK 0.014 0.043 -10000 0 -0.63 1 1
mol:Ca ++ -0.063 0.26 -10000 0 -0.54 36 36
BCAR1 0.017 0 -10000 0 -10000 0 0
PRKCB1 -0.22 0.24 -10000 0 -0.53 55 55
GNAQ 0.002 0.005 -10000 0 -10000 0 0
GNAZ 0.017 0 -10000 0 -10000 0 0
GNAL 0.017 0 -10000 0 -10000 0 0
Gs family/GDP -0.1 0.14 -10000 0 -0.47 16 16
ETA receptor/Endothelin-1/Gq/GTP 0.025 0.18 -10000 0 -0.47 9 9
MAPK14 -0.027 0.15 -10000 0 -0.43 14 14
TRPC6 0.039 0.18 -10000 0 -1 3 3
GNAI2 0.017 0 -10000 0 -10000 0 0
GNAI3 0.017 0 -10000 0 -10000 0 0
GNAI1 -0.07 0.22 -10000 0 -0.63 30 30
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.041 0.16 -10000 0 -0.45 16 16
ETB receptor/Endothelin-2 -0.4 0.21 -10000 0 -0.49 181 181
ETB receptor/Endothelin-3 -0.28 0.26 -10000 0 -0.5 123 123
ETB receptor/Endothelin-1 0.01 0.22 -10000 0 -0.5 28 28
MAPK3 -0.11 0.32 -10000 0 -0.8 34 34
MAPK1 -0.11 0.32 -10000 0 -0.8 34 34
Rac1/GDP -0.061 0.19 -10000 0 -0.53 12 12
cAMP biosynthetic process 0.017 0.19 -10000 0 -0.57 4 4
MAPK8 0.038 0.17 -10000 0 -0.58 4 4
SRC 0.017 0 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP 0.003 0.13 -10000 0 -0.44 6 6
p130Cas/CRK/Src/PYK2 -0.068 0.2 -10000 0 -0.58 11 11
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.061 0.19 -10000 0 -0.53 12 12
COL1A2 -0.064 0.38 -10000 0 -0.78 34 34
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.42 0.32 -10000 0 -0.55 180 180
mol:DAG -0.038 0.17 -10000 0 -0.45 12 12
MAP2K2 -0.084 0.25 -10000 0 -0.58 36 36
MAP2K1 -0.084 0.25 -10000 0 -0.59 35 35
EDNRA -0.048 0.35 -10000 0 -0.68 50 50
positive regulation of muscle contraction 0.013 0.24 -10000 0 -0.49 23 23
Gq family/GDP -0.097 0.18 -10000 0 -0.56 17 17
HRAS/GTP -0.071 0.18 -10000 0 -0.48 17 17
PRKCH -0.033 0.17 -10000 0 -0.59 7 7
RAC1 0.017 0 -10000 0 -10000 0 0
PRKCA -0.03 0.17 -10000 0 -0.58 6 6
PRKCB -0.038 0.16 -10000 0 -0.43 12 12
PRKCE -0.027 0.16 -10000 0 -0.57 5 5
PRKCD -0.028 0.16 -10000 0 -0.58 5 5
PRKCG -0.034 0.17 -10000 0 -0.55 8 8
regulation of vascular smooth muscle contraction -0.15 0.43 -10000 0 -1.1 34 34
PRKCQ -0.038 0.18 -10000 0 -0.56 10 10
PLA2G4A -0.1 0.27 -10000 0 -0.68 29 29
GNA14 -0.009 0.13 -10000 0 -0.64 9 9
GNA15 -0.006 0.13 -10000 0 -0.72 7 7
GNA12 0.017 0 -10000 0 -10000 0 0
GNA11 -0.001 0.1 -10000 0 -0.63 6 6
Rac1/GTP 0.083 0.31 0.34 119 -0.51 25 144
MMP1 -0.53 0.2 -10000 0 -0.6 199 199
IL6-mediated signaling events

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.25 0.22 -9999 0 -0.68 15 15
CRP -0.24 0.22 -9999 0 -0.73 7 7
cell cycle arrest -0.28 0.25 -9999 0 -0.75 23 23
TIMP1 -0.38 0.27 -9999 0 -0.69 71 71
IL6ST 0.012 0.011 -9999 0 -10000 0 0
Rac1/GDP -0.27 0.21 -9999 0 -0.51 71 71
AP1 -0.057 0.15 -9999 0 -0.65 2 2
GAB2 0.021 0.008 -9999 0 -10000 0 0
TNFSF11 -0.3 0.29 -9999 0 -0.81 33 33
HSP90B1 -0.024 0.093 -9999 0 -0.6 3 3
GAB1 0.014 0.061 -9999 0 -0.63 2 2
MAPK14 -0.23 0.22 -9999 0 -0.51 59 59
AKT1 0.065 0.027 -9999 0 -10000 0 0
FOXO1 0.057 0.078 -9999 0 -0.46 1 1
MAP2K6 -0.26 0.22 -9999 0 -0.54 65 65
mol:GTP -0.001 0.002 -9999 0 -10000 0 0
MAP2K4 -0.28 0.22 -9999 0 -0.56 54 54
MITF -0.26 0.2 -9999 0 -0.49 73 73
positive regulation of NF-kappaB transcription factor activity 0 0 -9999 0 -10000 0 0
TYK2 0.017 0 -9999 0 -10000 0 0
A2M -0.16 0.51 -9999 0 -1.5 29 29
CEBPB 0.008 0.12 -9999 0 -0.71 6 6
GRB2/SOS1/GAB family/SHP2 -0.064 0.092 -9999 0 -10000 0 0
STAT3 -0.3 0.26 -9999 0 -0.78 24 24
STAT1 -0.047 0.09 -9999 0 -0.33 19 19
CEBPD -0.25 0.22 -9999 0 -0.74 8 8
PIK3CA 0.019 0 -9999 0 -10000 0 0
PI3K 0.012 0.014 -9999 0 -10000 0 0
JUN 0 0.11 -9999 0 -0.72 5 5
PIAS3/MITF -0.24 0.2 -9999 0 -0.5 56 56
MAPK11 -0.23 0.22 -9999 0 -0.54 50 50
STAT3 (dimer)/FOXO1 -0.22 0.22 -9999 0 -0.69 15 15
GRB2/SOS1/GAB family -0.22 0.18 -9999 0 -0.5 32 32
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.29 0.22 -9999 0 -0.54 77 77
GRB2 0.019 0.005 -9999 0 -10000 0 0
JAK2 0.004 0.098 -9999 0 -0.72 4 4
LBP -0.19 0.19 -9999 0 -0.7 6 6
PIK3R1 0.018 0 -9999 0 -10000 0 0
JAK1 0.013 0.01 -9999 0 -10000 0 0
MYC -0.4 0.31 -9999 0 -0.79 48 48
FGG -0.25 0.22 -9999 0 -0.76 7 7
macrophage differentiation -0.28 0.25 -9999 0 -0.75 23 23
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.38 0.27 -9999 0 -0.64 91 91
JUNB -0.24 0.21 -9999 0 -0.7 8 8
FOS -0.08 0.23 -9999 0 -0.64 33 33
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.29 0.21 -9999 0 -0.49 92 92
STAT1/PIAS1 -0.26 0.19 -9999 0 -0.51 53 53
GRB2/SOS1/GAB family/SHP2/PI3K 0.047 0.031 -9999 0 -10000 0 0
STAT3 (dimer) -0.29 0.26 -9999 0 -0.78 23 23
PRKCD -0.27 0.22 -9999 0 -0.6 41 41
IL6R -0.34 0.32 -9999 0 -0.64 123 123
SOCS3 -0.21 0.22 -9999 0 -0.77 14 14
gp130 (dimer)/JAK1/JAK1/LMO4 -0.002 0.095 -9999 0 -0.44 9 9
Rac1/GTP -0.29 0.2 -9999 0 -0.51 79 79
HCK -0.044 0.19 -9999 0 -0.63 21 21
MAPKKK cascade -0.014 0.079 -9999 0 -10000 0 0
bone resorption -0.29 0.27 -9999 0 -0.76 33 33
IRF1 -0.25 0.23 -9999 0 -0.77 9 9
mol:GDP -0.29 0.21 -9999 0 -0.51 85 85
SOS1 0.02 0.008 -9999 0 -10000 0 0
VAV1 -0.3 0.22 -9999 0 -0.52 85 85
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.3 0.27 -9999 0 -0.59 75 75
PTPN11 -0.017 0.026 -9999 0 -10000 0 0
IL6/IL6RA -0.48 0.32 -9999 0 -0.63 174 174
gp130 (dimer)/TYK2/TYK2/LMO4 -0.008 0.092 -9999 0 -0.44 9 9
gp130 (dimer)/JAK2/JAK2/LMO4 -0.016 0.13 -9999 0 -0.57 10 10
IL6 -0.33 0.37 -9999 0 -0.73 104 104
PIAS3 0.014 0.049 -9999 0 -0.72 1 1
PTPRE 0.015 0.05 -9999 0 -0.71 1 1
PIAS1 0.017 0 -9999 0 -10000 0 0
RAC1 0.016 0.001 -9999 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.27 0.19 -9999 0 -0.49 73 73
LMO4 -0.017 0.14 -9999 0 -0.7 9 9
STAT3 (dimer)/PIAS3 -0.3 0.22 -9999 0 -0.73 24 24
MCL1 0.072 0.025 -9999 0 -10000 0 0
Osteopontin-mediated events

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.24 0.22 -9999 0 -0.46 47 47
NF kappa B1 p50/RelA/I kappa B alpha -0.23 0.17 -9999 0 -0.57 4 4
alphaV/beta3 Integrin/Osteopontin/Src -0.36 0.26 -9999 0 -0.54 151 151
AP1 -0.26 0.19 -9999 0 -0.62 26 26
ILK -0.25 0.22 -9999 0 -0.61 3 3
bone resorption -0.22 0.17 -9999 0 -0.68 8 8
PTK2B 0.017 0 -9999 0 -10000 0 0
PYK2/p130Cas -0.24 0.17 -9999 0 -0.78 1 1
ITGAV 0.015 0.05 -9999 0 -0.73 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 -0.022 0.11 -9999 0 -0.54 9 9
alphaV/beta3 Integrin/Osteopontin -0.31 0.22 -9999 0 -0.46 151 151
MAP3K1 -0.25 0.22 -9999 0 -0.46 51 51
JUN 0.001 0.11 -9999 0 -0.72 5 5
MAPK3 -0.25 0.23 -9999 0 -0.52 53 53
MAPK1 -0.25 0.23 -9999 0 -0.51 51 51
Rac1/GDP 0 0 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
MAPK8 -0.23 0.21 -9999 0 -0.6 3 3
ITGB3 0.018 0.005 -9999 0 -10000 0 0
NFKBIA -0.23 0.23 -9999 0 -0.52 53 53
FOS -0.079 0.23 -9999 0 -0.64 33 33
CD44 -0.013 0.14 -9999 0 -0.72 9 9
CHUK 0.017 0 -9999 0 -10000 0 0
PLAU -0.3 0.33 -9999 0 -0.8 52 52
NF kappa B1 p50/RelA -0.24 0.18 -9999 0 -0.63 5 5
BCAR1 0.017 0 -9999 0 -10000 0 0
RELA 0.017 0 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.002 0.037 -9999 0 -0.55 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
SYK -0.26 0.22 -9999 0 -0.46 51 51
VAV3 -0.28 0.27 -9999 0 -0.74 31 31
MAP3K14 -0.26 0.23 -9999 0 -0.5 52 52
ROCK2 0.017 0 -9999 0 -10000 0 0
SPP1 -0.48 0.35 -9999 0 -0.72 151 151
RAC1 0.017 0 -9999 0 -10000 0 0
Rac1/GTP -0.27 0.22 -9999 0 -0.67 31 31
MMP2 -0.19 0.2 -9999 0 -0.64 7 7
Canonical Wnt signaling pathway

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.083 0.053 -10000 0 -10000 0 0
AES 0.071 0.045 -10000 0 -10000 0 0
FBXW11 0.017 0 -10000 0 -10000 0 0
mol:GTP 0.003 0.002 -10000 0 -10000 0 0
LRP6/FZD1 -0.002 0.036 -10000 0 -0.54 1 1
SMAD4 0.008 0.075 -10000 0 -0.63 3 3
DKK2 -0.28 0.36 -10000 0 -0.72 89 89
TLE1 0.07 0.045 -10000 0 -10000 0 0
MACF1 0.018 0.001 -10000 0 -10000 0 0
CTNNB1 0.093 0.11 0.34 2 -10000 0 2
WIF1 -0.095 0.26 -10000 0 -0.72 34 34
beta catenin/RanBP3 0.31 0.2 0.49 106 -10000 0 106
KREMEN2 -0.12 0.29 -10000 0 -0.72 43 43
DKK1 -0.17 0.32 -10000 0 -0.72 56 56
beta catenin/beta TrCP1 0.1 0.098 0.33 2 -10000 0 2
FZD1 0.016 0.002 -10000 0 -10000 0 0
AXIN2 -0.45 0.33 -10000 0 -0.73 102 102
AXIN1 0.019 0.001 -10000 0 -10000 0 0
RAN 0.016 0.049 -10000 0 -0.72 1 1
Axin1/APC/GSK3/beta catenin 0.062 0.058 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.1 0.12 0.31 2 -10000 0 2
Axin1/APC/GSK3 0.14 0.084 0.24 24 -10000 0 24
Axin1/APC/GSK3/beta catenin/Macf1 0.091 0.072 -10000 0 -10000 0 0
HNF1A 0.073 0.047 -10000 0 -10000 0 0
CTBP1 0.074 0.048 -10000 0 -10000 0 0
MYC -0.43 0.33 -10000 0 -0.7 126 126
RANBP3 0.019 0.002 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.27 0.28 -10000 0 -0.52 115 115
NKD1 -0.54 0.32 -10000 0 -0.72 169 169
TCF4 0.075 0.048 -10000 0 -10000 0 0
TCF3 0.069 0.065 -10000 0 -0.61 1 1
WNT1/LRP6/FZD1/Axin1 0.001 0.03 -10000 0 -0.41 1 1
Ran/GTP 0.008 0.039 -10000 0 -0.55 1 1
CtBP/CBP/TCF/TLE1/AES 0.37 0.26 0.61 107 -10000 0 107
LEF1 -0.084 0.31 -10000 0 -0.66 49 49
DVL1 0.086 0.05 -10000 0 -10000 0 0
CSNK2A1 0.018 0.001 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES -0.078 0.12 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 -0.2 0.26 -10000 0 -0.51 89 89
LRP6 0.013 0.049 -10000 0 -0.72 1 1
CSNK1A1 0.083 0.052 -10000 0 -10000 0 0
NLK 0.003 0.007 -10000 0 -10000 0 0
CCND1 -0.24 0.25 -10000 0 -0.76 33 33
WNT1 0.016 0.003 -10000 0 -10000 0 0
GSK3A 0.017 0.001 -10000 0 -10000 0 0
GSK3B 0.013 0.05 -10000 0 -0.73 1 1
FRAT1 0.012 0.043 -10000 0 -0.63 1 1
PPP2R5D 0.27 0.14 0.35 169 -10000 0 169
APC 0.033 0.08 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.045 0.094 0.26 34 -10000 0 34
CREBBP 0.073 0.047 -10000 0 -10000 0 0
Arf6 signaling events

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B -0.004 0.038 -9999 0 -0.41 2 2
ARNO/beta Arrestin1-2 -0.11 0.14 -9999 0 -0.29 83 83
EGFR 0.002 0.099 -9999 0 -0.65 5 5
EPHA2 -0.016 0.15 -9999 0 -0.72 10 10
USP6 0.017 0 -9999 0 -10000 0 0
IQSEC1 0.017 0 -9999 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.15 0.23 -9999 0 -0.5 69 69
ARRB2 0.018 0.041 -9999 0 -0.33 3 3
mol:GTP 0.009 0.007 -9999 0 -10000 0 0
ARRB1 0.008 0.075 -9999 0 -0.63 3 3
FBXO8 0.017 0 -9999 0 -10000 0 0
TSHR 0.017 0 -9999 0 -10000 0 0
EGF -0.18 0.31 -9999 0 -0.67 65 65
somatostatin receptor activity 0 0 -9999 0 -0.001 51 51
ARAP2 0 0 -9999 0 0 54 54
mol:GDP -0.13 0.14 -9999 0 -0.32 59 59
mol:PI-3-4-5-P3 0 0 -9999 0 -0.001 51 51
ITGA2B 0.017 0 -9999 0 -10000 0 0
ARF6 0.017 0 -9999 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 -0.018 0.084 -9999 0 -10000 0 0
ADAP1 0 0 -9999 0 0 23 23
KIF13B 0.011 0.061 -9999 0 -0.63 2 2
HGF/MET -0.25 0.27 -9999 0 -0.54 103 103
PXN 0.017 0 -9999 0 -10000 0 0
ARF6/GTP -0.12 0.12 -9999 0 -0.28 52 52
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.13 0.2 -9999 0 -0.47 30 30
ADRB2 -0.22 0.31 -9999 0 -0.63 81 81
receptor agonist activity 0 0 -9999 0 0 48 48
actin filament binding 0 0 -9999 0 -0.001 52 52
SRC 0.017 0 -9999 0 -10000 0 0
ITGB3 0.017 0 -9999 0 -10000 0 0
GNAQ 0 0 -9999 0 -0.001 26 26
EFA6/PI-4-5-P2 0 0 -9999 0 -0.001 25 25
ARF6/GDP -0.017 0.057 -9999 0 -10000 0 0
ARF6/GDP/GULP/ACAP1 -0.14 0.17 -9999 0 -0.49 32 32
alphaIIb/beta3 Integrin/paxillin/GIT1 0 0 -9999 0 -10000 0 0
ACAP1 0 0 -9999 0 -10000 0 0
ACAP2 0 0 -9999 0 0 51 51
LHCGR/beta Arrestin2 -0.006 0.056 -9999 0 -0.48 3 3
EFNA1 0.017 0 -9999 0 -10000 0 0
HGF 0.01 0.07 -9999 0 -0.72 2 2
CYTH3 0 0 -9999 0 -0.001 50 50
CYTH2 -0.002 0.002 -9999 0 -0.004 63 63
NCK1 0.017 0 -9999 0 -10000 0 0
fibronectin binding 0 0 -9999 0 0 28 28
endosomal lumen acidification 0 0 -9999 0 0 25 25
microtubule-based process 0 0 -9999 0 -10000 0 0
GULP1 -0.051 0.2 -9999 0 -0.64 23 23
GNAQ/ARNO -0.003 0.003 -9999 0 -0.007 24 24
mol:Phosphatidic acid 0 0 -9999 0 0 51 51
PIP3-E 0.011 0.065 -9999 0 -0.68 2 2
MET -0.32 0.37 -9999 0 -0.72 101 101
GNA14 -0.009 0.13 -9999 0 -0.63 9 9
GNA15 -0.006 0.13 -9999 0 -0.72 7 7
GIT1 0.017 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -0.001 46 46
GNA11 -0.001 0.1 -9999 0 -0.63 6 6
LHCGR 0.007 0.082 -9999 0 -0.69 3 3
AGTR1 -0.26 0.32 -9999 0 -0.63 96 96
desensitization of G-protein coupled receptor protein signaling pathway -0.006 0.055 -9999 0 -0.48 3 3
IPCEF1/ARNO -0.093 0.17 -9999 0 -0.38 32 32
alphaIIb/beta3 Integrin 0 0 -9999 0 -10000 0 0
BMP receptor signaling

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.2 0.19 -9999 0 -0.78 1 1
SMAD6-7/SMURF1 -0.014 0.078 -9999 0 -0.45 7 7
NOG 0.017 0 -9999 0 -10000 0 0
SMAD9 -0.1 0.19 -9999 0 -0.54 31 31
SMAD4 0.008 0.075 -9999 0 -0.63 3 3
SMAD5 -0.15 0.18 -9999 0 -0.48 33 33
BMP7/USAG1 -0.45 0.31 -9999 0 -0.61 166 166
SMAD5/SKI -0.13 0.18 -9999 0 -0.48 23 23
SMAD1 0.024 0.083 -9999 0 -0.55 3 3
BMP2 -0.096 0.25 -9999 0 -0.63 39 39
SMAD1/SMAD1/SMAD4 -0.02 0.076 -9999 0 -0.47 1 1
BMPR1A 0.017 0 -9999 0 -10000 0 0
BMPR1B 0.007 0.085 -9999 0 -0.72 3 3
BMPR1A-1B/BAMBI -0.065 0.16 -9999 0 -0.46 32 32
AHSG 0.017 0 -9999 0 -10000 0 0
CER1 0.014 0.049 -9999 0 -0.72 1 1
BMP2-4/CER1 -0.22 0.28 -9999 0 -0.55 71 71
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.038 0.14 -9999 0 -0.42 2 2
BMP2-4 (homodimer) -0.25 0.31 -9999 0 -0.59 94 94
RGMB 0 0.11 -9999 0 -0.72 5 5
BMP6/BMPR2/BMPR1A-1B -0.14 0.17 -9999 0 -0.76 1 1
RGMA 0.005 0.086 -9999 0 -0.63 4 4
SMURF1 0.017 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.062 0.14 -9999 0 -0.37 24 24
BMP2-4/USAG1 -0.36 0.34 -9999 0 -0.72 84 84
SMAD6/SMURF1/SMAD5 -0.13 0.18 -9999 0 -0.48 23 23
SOSTDC1 -0.24 0.32 -9999 0 -0.63 90 90
BMP7/BMPR2/BMPR1A-1B -0.22 0.21 -9999 0 -0.41 119 119
SKI 0.017 0 -9999 0 -10000 0 0
BMP6 (homodimer) -0.23 0.32 -9999 0 -0.63 86 86
HFE2 0.017 0 -9999 0 -10000 0 0
ZFYVE16 0.017 0 -9999 0 -10000 0 0
MAP3K7 0.017 0 -9999 0 -10000 0 0
BMP2-4/CHRD -0.21 0.27 -9999 0 -0.55 71 71
SMAD5/SMAD5/SMAD4 -0.14 0.18 -9999 0 -0.49 24 24
MAPK1 0.014 0.043 -9999 0 -0.63 1 1
TAK1/TAB family -0.063 0.089 -9999 0 -10000 0 0
BMP7 (homodimer) -0.37 0.37 -9999 0 -0.72 117 117
NUP214 0.017 0 -9999 0 -10000 0 0
BMP6/FETUA -0.18 0.22 -9999 0 -0.46 86 86
SMAD1/SKI 0.032 0.079 -9999 0 -0.51 3 3
SMAD6 -0.003 0.12 -9999 0 -0.72 6 6
CTDSP2 0.008 0.075 -9999 0 -0.63 3 3
BMP2-4/FETUA -0.21 0.27 -9999 0 -0.51 94 94
MAP3K7IP1 0.017 0 -9999 0 -10000 0 0
GREM1 -0.035 0.19 -9999 0 -0.72 16 16
BMPR2 (homodimer) 0.017 0 -9999 0 -10000 0 0
GADD34/PP1CA -0.002 0.03 -9999 0 -0.46 1 1
BMPR1A-1B (homodimer) -0.007 0.062 -9999 0 -0.54 3 3
CHRDL1 0.011 0.065 -9999 0 -0.68 2 2
ENDOFIN/SMAD1 0.032 0.079 -9999 0 -0.51 3 3
SMAD6-7/SMURF1/SMAD1 -0.012 0.084 -9999 0 -0.53 1 1
SMAD6/SMURF1 0.017 0 -9999 0 -10000 0 0
BAMBI -0.079 0.25 -9999 0 -0.72 29 29
SMURF2 -0.029 0.18 -9999 0 -0.72 14 14
BMP2-4/CHRDL1 -0.22 0.28 -9999 0 -0.55 71 71
BMP2-4/GREM1 -0.24 0.3 -9999 0 -0.58 81 81
SMAD7 0.014 0.043 -9999 0 -0.63 1 1
SMAD8A/SMAD8A/SMAD4 -0.069 0.19 -9999 0 -0.5 32 32
SMAD1/SMAD6 0.032 0.079 -9999 0 -0.51 3 3
TAK1/SMAD6 0 0 -9999 0 -10000 0 0
BMP7 -0.37 0.37 -9999 0 -0.72 117 117
BMP6 -0.23 0.32 -9999 0 -0.63 86 86
MAP3K7IP2 0.017 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.04 0.13 -9999 0 -0.32 24 24
PPM1A 0.017 0 -9999 0 -10000 0 0
SMAD1/SMURF2 0.007 0.13 -9999 0 -0.63 3 3
SMAD7/SMURF1 -0.002 0.031 -9999 0 -0.46 1 1
CTDSPL 0.011 0.061 -9999 0 -0.63 2 2
PPP1CA 0.014 0.049 -9999 0 -0.72 1 1
XIAP 0 0 -9999 0 -10000 0 0
CTDSP1 0.017 0 -9999 0 -10000 0 0
PPP1R15A 0.017 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.055 0.14 -9999 0 -0.37 23 23
CHRD 0.017 0 -9999 0 -10000 0 0
BMPR2 0.017 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.065 0.16 -9999 0 -0.4 24 24
BMP4 -0.22 0.34 -9999 0 -0.72 73 73
FST 0.017 0 -9999 0 -10000 0 0
BMP2-4/NOG -0.21 0.27 -9999 0 -0.51 94 94
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.2 0.19 -9999 0 -0.78 1 1
Wnt signaling

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.12 0.18 -9999 0 -0.47 25 25
FZD6 -0.029 0.18 -9999 0 -0.72 14 14
WNT6 0.014 0.049 -9999 0 -0.72 1 1
WNT4 -0.01 0.13 -9999 0 -0.65 9 9
FZD3 -0.14 0.3 -9999 0 -0.72 48 48
WNT5A -0.092 0.26 -9999 0 -0.72 33 33
WNT11 -0.14 0.3 -9999 0 -0.72 46 46
Visual signal transduction: Rods

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.017 0 -9999 0 -10000 0 0
GNAT1/GTP 0 0 -9999 0 -10000 0 0
Metarhodopsin II/Arrestin -0.28 0.18 -9999 0 -0.4 161 161
PDE6G/GNAT1/GTP 0 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
GNAT1 0.017 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
CNG Channel -0.25 0.21 -9999 0 -0.6 44 44
mol:Na + -0.14 0.16 -9999 0 -0.62 7 7
mol:ADP 0 0 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.15 0.2 -9999 0 -0.54 9 9
mol:GDP 0 0 -9999 0 -10000 0 0
cGMP/CNG Channel -0.14 0.16 -9999 0 -0.64 7 7
CNGB1 0.017 0 -9999 0 -10000 0 0
RDH5 -0.15 0.29 -9999 0 -0.63 59 59
SAG -0.45 0.29 -9999 0 -0.63 161 161
mol:Ca2+ -0.091 0.18 -9999 0 -0.59 7 7
Na + (4 Units) -0.13 0.14 -9999 0 -0.57 7 7
RGS9 -0.2 0.31 -9999 0 -0.63 75 75
GNB1/GNGT1 -0.24 0.27 -9999 0 -0.54 98 98
GNAT1/GDP -0.12 0.16 -9999 0 -0.72 2 2
GUCY2D 0.017 0 -9999 0 -10000 0 0
GNGT1 -0.31 0.37 -9999 0 -0.72 98 98
GUCY2F 0.008 0.078 -9999 0 -0.66 3 3
GNB5 0.007 0.085 -9999 0 -0.72 3 3
mol:GMP (4 units) -0.1 0.18 -9999 0 -10000 0 0
mol:11-cis-retinal -0.15 0.28 -9999 0 -0.63 59 59
mol:cGMP -0.019 0.08 -9999 0 -10000 0 0
GNB1 0.017 0 -9999 0 -10000 0 0
Rhodopsin -0.12 0.2 -9999 0 -0.46 59 59
SLC24A1 0.017 0 -9999 0 -10000 0 0
CNGA1 -0.28 0.32 -9999 0 -0.63 104 104
Metarhodopsin II 0 0 -9999 0 -10000 0 0
mol:Ca ++ 0 0 -9999 0 -10000 0 0
GC1/GCAP Family -0.016 0.077 -9999 0 -10000 0 0
RGS9BP -0.003 0.12 -9999 0 -0.72 6 6
Metarhodopsin II/Transducin -0.079 0.13 -9999 0 -10000 0 0
GCAP Family/Ca ++ -0.016 0.079 -9999 0 -0.42 7 7
PDE6A/B -0.18 0.22 -9999 0 -0.46 89 89
mol:Pi -0.15 0.2 -9999 0 -0.53 9 9
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
Transducin -0.18 0.21 -9999 0 -0.42 98 98
PDE6B 0.017 0 -9999 0 -10000 0 0
PDE6A -0.24 0.32 -9999 0 -0.63 89 89
PDE6G 0.017 0 -9999 0 -10000 0 0
RHO 0.017 0 -9999 0 -10000 0 0
PDE6 -0.23 0.23 -9999 0 -0.64 37 37
GUCA1A 0.014 0.049 -9999 0 -0.72 1 1
GC2/GCAP Family -0.021 0.087 -9999 0 -0.41 8 8
GUCA1C 0.004 0.092 -9999 0 -0.68 4 4
GUCA1B 0.004 0.098 -9999 0 -0.72 4 4
TCGA08_p53

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.16 0.26 -10000 0 -0.55 70 70
TP53 -0.057 0.082 -10000 0 -0.27 9 9
Senescence -0.057 0.082 -10000 0 -0.27 9 9
Apoptosis -0.057 0.082 -10000 0 -0.27 9 9
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.087 0.13 0.28 70 -10000 0 70
MDM4 0.017 0 -10000 0 -10000 0 0
Syndecan-2-mediated signaling events

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin -0.027 0.16 -9999 0 -0.46 27 27
EPHB2 -0.002 0.12 -9999 0 -0.71 6 6
Syndecan-2/TACI 0.023 0.065 -9999 0 -0.4 5 5
LAMA1 0.017 0 -9999 0 -10000 0 0
Syndecan-2/alpha2 ITGB1 -0.14 0.19 -9999 0 -0.64 2 2
HRAS 0.017 0 -9999 0 -10000 0 0
Syndecan-2/CASK -0.003 0.032 -9999 0 -0.46 1 1
ITGA5 0 0.11 -9999 0 -0.72 5 5
BAX 0.051 0.05 -9999 0 -0.55 1 1
EPB41 0.017 0 -9999 0 -10000 0 0
positive regulation of cell-cell adhesion -0.002 0.028 -9999 0 -0.41 1 1
LAMA3 0.002 0.1 -9999 0 -0.67 5 5
EZR 0 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
CAV2 -0.009 0.14 -9999 0 -0.71 8 8
Syndecan-2/MMP2 0.026 0.057 -9999 0 -0.46 3 3
RP11-540L11.1 0 0 -9999 0 -10000 0 0
alpha2 ITGB1 -0.19 0.26 -9999 0 -0.54 78 78
dendrite morphogenesis 0.017 0.084 -9999 0 -0.45 7 7
Syndecan-2/GM-CSF -0.24 0.25 -9999 0 -0.46 121 121
determination of left/right symmetry 0.024 0.04 -9999 0 -0.54 1 1
Syndecan-2/PKC delta 0.03 0.034 -9999 0 -0.45 1 1
GNB2L1 0.017 0 -9999 0 -10000 0 0
MAPK3 -0.21 0.23 -9999 0 -0.42 122 122
MAPK1 -0.2 0.23 -9999 0 -0.41 122 122
Syndecan-2/RACK1 -0.002 0.026 -9999 0 -0.38 1 1
NF1 0.017 0 -9999 0 -10000 0 0
FGFR/FGF/Syndecan-2 0.024 0.04 -9999 0 -0.54 1 1
ITGA2 -0.24 0.35 -9999 0 -0.72 78 78
MAPK8 0.044 0.039 -9999 0 -0.45 1 1
Syndecan-2/alpha2/beta1 Integrin -0.14 0.19 -9999 0 -0.64 2 2
Syndecan-2/Kininogen 0.017 0.082 -9999 0 -0.4 8 8
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
SRC 0.048 0.028 -9999 0 -0.36 1 1
Syndecan-2/CASK/Protein 4.1 -0.002 0.029 -9999 0 -0.42 1 1
extracellular matrix organization 0.03 0.034 -9999 0 -0.45 1 1
actin cytoskeleton reorganization -0.027 0.16 -9999 0 -0.46 27 27
Syndecan-2/Caveolin-2/Ras -0.017 0.079 -9999 0 -0.4 9 9
Syndecan-2/Laminin alpha3 0.02 0.074 -9999 0 -0.42 6 6
Syndecan-2/RasGAP -0.005 0.042 -9999 0 -0.36 3 3
alpha5/beta1 Integrin -0.014 0.087 -9999 0 -0.54 6 6
PRKCD 0.017 0 -9999 0 -10000 0 0
Syndecan-2 dimer 0.017 0.084 -9999 0 -0.45 7 7
GO:0007205 0.004 0.008 -9999 0 -10000 0 0
DNA mediated transformation 0 0 -9999 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.053 0.047 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
SDCBP 0.017 0 -9999 0 -10000 0 0
TNFRSF13B 0.005 0.086 -9999 0 -0.63 4 4
RASA1 0.01 0.07 -9999 0 -0.72 2 2
alpha2/beta1 Integrin -0.19 0.26 -9999 0 -0.54 78 78
Syndecan-2/Synbindin 0.03 0.034 -9999 0 -0.45 1 1
TGFB1 0.017 0 -9999 0 -10000 0 0
CASP3 0.04 0.04 -9999 0 -0.4 1 1
FN1 -0.069 0.24 -9999 0 -0.72 26 26
Syndecan-2/IL8 -0.42 0.13 -9999 0 -0.46 207 207
SDC2 0.024 0.04 -9999 0 -0.54 1 1
KNG1 -0.004 0.12 -9999 0 -0.64 7 7
Syndecan-2/Neurofibromin 0.03 0.034 -9999 0 -0.45 1 1
TRAPPC4 0.017 0 -9999 0 -10000 0 0
CSF2 -0.38 0.37 -9999 0 -0.72 121 121
Syndecan-2/TGFB1 0.03 0.034 -9999 0 -0.45 1 1
Syndecan-2/Syntenin/PI-4-5-P2 -0.002 0.029 -9999 0 -0.42 1 1
Syndecan-2/Ezrin -0.002 0.029 -9999 0 -0.42 1 1
PRKACA 0.042 0.031 -9999 0 -0.4 1 1
angiogenesis -0.42 0.13 -9999 0 -0.46 207 207
MMP2 0.01 0.07 -9999 0 -0.72 2 2
IL8 -0.67 0.2 -9999 0 -0.72 207 207
calcineurin-NFAT signaling pathway 0.023 0.064 -9999 0 -0.4 5 5
Signaling events mediated by PRL

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 -0.033 0.18 -10000 0 -0.72 15 15
mol:Halofuginone 0.007 0.001 -10000 0 -10000 0 0
ITGA1 0.01 0.07 -10000 0 -0.72 2 2
CDKN1A 0.032 0.063 -10000 0 -0.39 3 3
PRL-3/alpha Tubulin -0.17 0.25 -10000 0 -0.54 70 70
mol:Ca2+ -0.1 0.29 0.34 35 -0.5 69 104
AGT -0.21 0.34 -10000 0 -0.72 69 69
CCNA2 -0.024 0.17 -10000 0 -0.7 1 1
TUBA1B 0.017 0 -10000 0 -10000 0 0
EGR1 0.008 0.11 -10000 0 -0.48 11 11
CDK2/Cyclin E1 -0.074 0.16 -10000 0 -0.69 6 6
MAPK3 -0.15 0.26 -10000 0 -0.54 72 72
PRL-2 /Rab GGTase beta 0 0 -10000 0 -10000 0 0
MAPK1 -0.15 0.27 -10000 0 -0.54 70 70
PTP4A1 0.032 0.088 -10000 0 -10000 0 0
PTP4A3 -0.21 0.34 -10000 0 -0.72 70 70
PTP4A2 0.017 0 -10000 0 -10000 0 0
ITGB1 -0.15 0.26 -10000 0 -0.54 71 71
SRC 0.017 0 -10000 0 -10000 0 0
RAC1 -0.032 0.11 -10000 0 -0.36 4 4
Rab GGTase beta/Rab GGTase alpha 0 0 -10000 0 -10000 0 0
PRL-1/ATF-5 0.037 0.082 -10000 0 -10000 0 0
RABGGTA 0.017 0 -10000 0 -10000 0 0
BCAR1 0.1 0.16 0.34 70 -10000 0 70
RHOC -0.032 0.11 -10000 0 -0.36 4 4
RHOA -0.032 0.11 -10000 0 -0.36 4 4
cell motility -0.028 0.11 -10000 0 -0.37 4 4
PRL-1/alpha Tubulin 0.037 0.082 -10000 0 -10000 0 0
PRL-3/alpha1 Integrin -0.17 0.26 -10000 0 -0.55 71 71
ROCK1 -0.028 0.11 -10000 0 -0.37 4 4
RABGGTB 0.017 0 -10000 0 -10000 0 0
CDK2 -0.066 0.23 -10000 0 -0.72 25 25
mitosis 0.032 0.087 -10000 0 -10000 0 0
ATF5 0.017 0 -10000 0 -10000 0 0
IL4-mediated signaling events

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.33 0.52 -10000 0 -1.2 37 37
STAT6 (cleaved dimer) -0.44 0.47 -10000 0 -1.1 63 63
IGHG1 -0.1 0.2 -10000 0 -0.55 3 3
IGHG3 -0.33 0.49 -10000 0 -1 51 51
AKT1 -0.14 0.3 -10000 0 -0.74 10 10
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.11 0.25 -10000 0 -0.91 4 4
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.14 0.28 -10000 0 -1 3 3
THY1 -0.36 0.55 -10000 0 -1.2 41 41
MYB 0.011 0.061 -10000 0 -0.63 2 2
HMGA1 0.017 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.24 0.36 -10000 0 -0.85 32 32
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.15 0.28 -10000 0 -0.91 4 4
SP1 0.023 0.013 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 0.03 0.024 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.42 0.46 -10000 0 -1.1 54 54
SOCS1 -0.2 0.36 -10000 0 -0.79 18 18
SOCS3 -0.19 0.33 -10000 0 -0.81 23 23
FCER2 -0.28 0.45 -10000 0 -1.1 23 23
PARP14 0.012 0.07 -10000 0 -0.72 2 2
CCL17 -0.35 0.54 -10000 0 -1.2 37 37
GRB2 0.017 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.1 0.23 -10000 0 -0.76 3 3
T cell proliferation -0.33 0.52 -10000 0 -1.2 37 37
IL4R/JAK1 -0.34 0.51 -10000 0 -1.2 38 38
EGR2 -0.36 0.56 -10000 0 -1.3 40 40
JAK2 -0.001 0.1 -10000 0 -0.74 4 4
JAK3 0.016 0.015 -10000 0 -10000 0 0
PIK3R1 0.017 0 -10000 0 -10000 0 0
JAK1 0.013 0.019 -10000 0 -10000 0 0
COL1A2 -0.17 0.31 -10000 0 -0.74 39 39
CCL26 -0.4 0.55 -10000 0 -1.2 46 46
IL4R -0.36 0.55 -10000 0 -1.2 38 38
PTPN6 0.023 0.015 -10000 0 -10000 0 0
IL13RA2 -0.44 0.56 -10000 0 -1.2 50 50
IL13RA1 0.013 0.03 -10000 0 -10000 0 0
IRF4 -0.34 0.63 -10000 0 -1.5 51 51
ARG1 -0.053 0.18 -10000 0 -0.76 4 4
CBL -0.21 0.35 -10000 0 -0.8 32 32
GTF3A -0.38 0.4 -10000 0 -0.81 103 103
PIK3CA 0.017 0 -10000 0 -10000 0 0
IL13RA1/JAK2 0 0.093 -10000 0 -0.57 4 4
IRF4/BCL6 -0.35 0.56 -10000 0 -1.4 51 51
CD40LG 0.013 0.067 -10000 0 -0.63 2 2
MAPK14 -0.21 0.35 -10000 0 -0.82 31 31
mitosis -0.13 0.28 -10000 0 -0.7 10 10
STAT6 -0.42 0.55 -10000 0 -1.3 42 42
SPI1 0.024 0.013 -10000 0 -10000 0 0
RPS6KB1 -0.12 0.28 -10000 0 -0.7 7 7
STAT6 (dimer) -0.39 0.58 -10000 0 -1.3 42 42
STAT6 (dimer)/PARP14 -0.36 0.54 -10000 0 -1.2 43 43
mast cell activation 0.007 0.016 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.15 0.29 -10000 0 -0.8 9 9
FRAP1 -0.14 0.3 -10000 0 -0.74 10 10
LTA -0.33 0.51 -10000 0 -1.2 36 36
FES 0.011 0.065 -10000 0 -0.68 2 2
T-helper 1 cell differentiation 0.38 0.57 1.3 42 -10000 0 42
CCL11 -0.44 0.63 -10000 0 -1.4 57 57
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.14 0.28 -10000 0 -0.78 9 9
IL2RG 0.007 0.077 -10000 0 -0.64 3 3
IL10 -0.33 0.51 -10000 0 -1.2 36 36
IRS1 0.004 0.098 -10000 0 -0.72 4 4
IRS2 0.014 0.049 -10000 0 -0.72 1 1
IL4 -0.048 0.15 -10000 0 -0.81 1 1
IL5 -0.35 0.54 -10000 0 -1.2 43 43
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.27 0.42 -10000 0 -0.89 34 34
COL1A1 -0.56 0.35 -10000 0 -0.88 94 94
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.34 0.52 -10000 0 -1.3 30 30
IL2R gamma/JAK3 0.017 0.062 -10000 0 -0.48 3 3
TFF3 -0.34 0.53 -10000 0 -1.2 37 37
ALOX15 -0.34 0.52 -10000 0 -1.2 37 37
MYBL1 0.004 0.098 -10000 0 -0.72 4 4
T-helper 2 cell differentiation -0.28 0.42 -10000 0 -0.94 35 35
SHC1 0.017 0 -10000 0 -10000 0 0
CEBPB 0.005 0.12 -10000 0 -0.71 6 6
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.13 0.27 -10000 0 -0.91 4 4
mol:PI-3-4-5-P3 -0.14 0.3 -10000 0 -0.74 10 10
PI3K -0.15 0.31 -10000 0 -0.8 10 10
DOK2 0.008 0.075 -10000 0 -0.63 3 3
ETS1 0.024 0.016 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.09 0.22 -10000 0 -0.71 3 3
ITGB3 -0.33 0.51 -10000 0 -1.2 38 38
PIGR -0.37 0.58 -10000 0 -1.3 41 41
IGHE 0.026 0.069 -10000 0 -10000 0 0
MAPKKK cascade -0.088 0.21 -10000 0 -0.7 3 3
BCL6 0.01 0.065 -10000 0 -0.68 2 2
OPRM1 -0.33 0.51 -10000 0 -1.2 34 34
RETNLB -0.52 0.72 -10000 0 -1.5 67 67
SELP -0.43 0.65 -10000 0 -1.5 49 49
AICDA -0.38 0.57 -10000 0 -1.2 48 48
Syndecan-3-mediated signaling events

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.017 0 -9999 0 -10000 0 0
Syndecan-3/Src/Cortactin -0.12 0.14 -9999 0 -0.56 1 1
Syndecan-3/Neurocan -0.003 0.021 -9999 0 -10000 0 0
POMC 0.014 0.043 -9999 0 -0.63 1 1
EGFR 0.002 0.099 -9999 0 -0.65 5 5
Syndecan-3/EGFR -0.011 0.057 -9999 0 -0.4 3 3
AGRP 0.014 0.049 -9999 0 -0.72 1 1
NCSTN 0.017 0 -9999 0 -10000 0 0
PSENEN 0.017 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.014 0.049 -9999 0 -0.72 1 1
APH1A -0.007 0.12 -9999 0 -0.64 8 8
NCAN 0.017 0 -9999 0 -10000 0 0
long-term memory -0.004 0.026 -9999 0 -10000 0 0
Syndecan-3/IL8 -0.36 0.11 -9999 0 -0.39 207 207
PSEN1 0.017 0 -9999 0 -10000 0 0
Src/Cortactin 0 0 -9999 0 -10000 0 0
FYN 0.014 0.043 -9999 0 -0.63 1 1
limb bud formation -0.004 0.023 -9999 0 -0.3 1 1
MC4R 0.017 0 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
PTN -0.24 0.32 -9999 0 -0.63 90 90
FGFR/FGF/Syndecan-3 -0.004 0.023 -9999 0 -0.3 1 1
neuron projection morphogenesis -0.11 0.13 -9999 0 -0.53 1 1
Syndecan-3/AgRP -0.005 0.033 -9999 0 -0.38 1 1
Syndecan-3/AgRP/MC4R -0.004 0.03 -9999 0 -0.36 1 1
Fyn/Cortactin -0.002 0.031 -9999 0 -0.46 1 1
SDC3 -0.004 0.024 -9999 0 -0.3 1 1
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.35 0.1 -9999 0 -0.38 207 207
IL8 -0.67 0.2 -9999 0 -0.72 207 207
Syndecan-3/Fyn/Cortactin -0.004 0.027 -9999 0 -10000 0 0
Syndecan-3/CASK -0.004 0.022 -9999 0 -0.28 1 1
alpha-MSH/MC4R -0.002 0.031 -9999 0 -0.46 1 1
Gamma Secretase -0.013 0.064 -9999 0 -10000 0 0
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.017 0 -9999 0 -10000 0 0
VLDLR -0.12 0.27 -9999 0 -0.63 48 48
LRPAP1 0.017 0 -9999 0 -10000 0 0
NUDC 0.017 0 -9999 0 -10000 0 0
RELN/LRP8 -0.4 0.15 -9999 0 -0.46 197 197
CaM/Ca2+ 0 0 -9999 0 -10000 0 0
KATNA1 0.017 0 -9999 0 -10000 0 0
GO:0030286 0 0 -9999 0 -10000 0 0
ABL1 -0.35 0.15 -9999 0 -0.41 197 197
IQGAP1/CaM 0 0 -9999 0 -10000 0 0
DAB1 0.017 0 -9999 0 -10000 0 0
IQGAP1 0.017 0 -9999 0 -10000 0 0
PLA2G7 -0.024 0.16 -9999 0 -0.63 14 14
CALM1 0.017 0 -9999 0 -10000 0 0
DYNLT1 0.017 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
LRPAP1/LRP8 -0.47 0.18 -9999 0 -0.54 197 197
UniProt:Q4QZ09 0 0 -9999 0 -10000 0 0
CLIP1 0.017 0 -9999 0 -10000 0 0
CDK5R1 0.017 0 -9999 0 -10000 0 0
LIS1/Poliovirus Protein 3A 0 0 -9999 0 -10000 0 0
CDK5R2 0.017 0 -9999 0 -10000 0 0
mol:PP1 0 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1 -0.082 0.16 -9999 0 -0.46 1 1
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
NDEL1/14-3-3 E -0.25 0.12 -9999 0 -0.61 2 2
MAP1B -0.025 0.087 -9999 0 -0.33 17 17
RAC1 0 0 -9999 0 -10000 0 0
p35/CDK5 -0.3 0.14 -9999 0 -0.72 2 2
RELN 0.017 0 -9999 0 -10000 0 0
PAFAH/LIS1 0.01 0.1 -9999 0 -0.38 14 14
LIS1/CLIP170 0.036 0 -9999 0 -10000 0 0
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.19 0.073 -9999 0 -0.46 2 2
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.033 0.14 -9999 0 -0.56 3 3
GO:0005869 0 0 -9999 0 -10000 0 0
NDEL1 -0.27 0.13 -9999 0 -0.66 2 2
LIS1/IQGAP1 0.036 0 -9999 0 -10000 0 0
RHOA 0 0 -9999 0 -10000 0 0
PAFAH1B1 0.031 0 -9999 0 -10000 0 0
PAFAH1B3 -0.062 0.23 -9999 0 -0.72 24 24
PAFAH1B2 0.017 0 -9999 0 -10000 0 0
MAP1B/LIS1/Dynein heavy chain 0.017 0.061 -9999 0 -10000 0 0
NDEL1/Katanin 60/Dynein heavy chain -0.24 0.093 -9999 0 -0.58 2 2
LRP8 -0.63 0.24 -9999 0 -0.72 197 197
NDEL1/Katanin 60 -0.24 0.12 -9999 0 -0.61 2 2
P39/CDK5 -0.3 0.14 -9999 0 -0.72 2 2
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.036 0 -9999 0 -10000 0 0
CDK5 -0.32 0.14 -9999 0 -0.77 2 2
PPP2R5D 0.017 0 -9999 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0 0 -9999 0 -10000 0 0
CSNK2A1 0.017 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.067 0.13 -9999 0 -10000 0 0
RELN/VLDLR -0.43 0.2 -9999 0 -0.48 197 197
CDC42 0 0 -9999 0 -10000 0 0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 -0.24 0.27 -10000 0 -0.54 101 101
CRKL -0.049 0.12 -10000 0 -0.52 2 2
mol:PIP3 -0.01 0.095 0.56 6 -10000 0 6
AKT1 0.014 0.063 0.39 6 -10000 0 6
PTK2B 0.017 0 -10000 0 -10000 0 0
RAPGEF1 -0.037 0.11 -10000 0 -0.48 2 2
RANBP10 0.017 0 -10000 0 -10000 0 0
PIK3CA 0.017 0 -10000 0 -10000 0 0
HGF/MET/SHIP2 -0.21 0.23 -10000 0 -0.46 103 103
MAP3K5 -0.025 0.11 -10000 0 -0.54 1 1
HGF/MET/CIN85/CBL/ENDOPHILINS -0.19 0.21 -10000 0 -0.42 103 103
AP1 -0.13 0.18 -10000 0 -0.49 37 37
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.017 0 -10000 0 -10000 0 0
apoptosis -0.14 0.26 -10000 0 -0.76 32 32
STAT3 (dimer) -0.052 0.12 -10000 0 -0.38 1 1
GAB1/CRKL/SHP2/PI3K -0.061 0.078 -10000 0 -0.52 2 2
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK -0.039 0.11 -10000 0 -0.48 2 2
PTPN11 0.014 0.049 -10000 0 -0.72 1 1
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 -0.033 0.18 -10000 0 -0.72 15 15
PTEN 0 0.1 -10000 0 -0.63 6 6
ELK1 -0.11 0.13 0.24 1 -0.26 99 100
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 -0.049 0.064 -10000 0 -0.27 2 2
PAK1 0.023 0.058 0.37 6 -10000 0 6
HGF/MET/RANBP10 -0.21 0.23 -10000 0 -0.46 103 103
HRAS -0.084 0.15 -10000 0 -10000 0 0
DOCK1 -0.04 0.12 -10000 0 -0.48 3 3
GAB1 -0.062 0.12 -10000 0 -0.56 2 2
CRK -0.051 0.12 -10000 0 -0.52 2 2
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP -0.12 0.13 -10000 0 -10000 0 0
JUN 0 0.11 -10000 0 -0.72 5 5
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET -0.11 0.12 -10000 0 -0.25 92 92
PIK3R1 0.017 0 -10000 0 -10000 0 0
cell morphogenesis -0.01 0.12 -10000 0 -10000 0 0
GRB2/SHC -0.065 0.12 -10000 0 -10000 0 0
FOS -0.08 0.23 -10000 0 -0.64 33 33
GLMN 0.006 0.043 -10000 0 -0.23 3 3
cell motility -0.11 0.13 0.23 1 -0.26 99 100
HGF/MET/MUC20 -0.22 0.23 -10000 0 -0.47 103 103
cell migration -0.084 0.099 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
CBL 0.017 0 -10000 0 -10000 0 0
MET/RANBP10 -0.24 0.27 -10000 0 -0.54 101 101
HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.071 0.13 -10000 0 -0.42 1 1
MET/MUC20 -0.25 0.27 -10000 0 -0.55 101 101
RAP1B -0.025 0.11 -10000 0 -0.55 1 1
RAP1A -0.025 0.11 -10000 0 -0.55 1 1
HGF/MET/RANBP9 -0.21 0.23 -10000 0 -0.46 103 103
RAF1 -0.068 0.14 -10000 0 -10000 0 0
STAT3 -0.052 0.12 -10000 0 -0.38 1 1
cell proliferation -0.051 0.14 -10000 0 -10000 0 0
RPS6KB1 -0.024 0.057 -10000 0 -0.22 2 2
MAPK3 -0.1 0.14 0.7 2 -10000 0 2
MAPK1 -0.11 0.13 0.68 1 -0.24 100 101
RANBP9 0.017 0 -10000 0 -10000 0 0
MAPK8 -0.001 0.1 -10000 0 -0.42 1 1
SRC -0.055 0.12 -10000 0 -0.39 1 1
PI3K -0.065 0.12 -10000 0 -10000 0 0
MET/Glomulin -0.21 0.25 -10000 0 -0.49 101 101
SOS1 0.017 0 -10000 0 -10000 0 0
MAP2K1 -0.054 0.14 -10000 0 -10000 0 0
MET -0.32 0.37 -10000 0 -0.72 101 101
MAP4K1 -0.033 0.11 -10000 0 -0.48 2 2
PTK2 0.014 0.049 -10000 0 -0.72 1 1
MAP2K2 -0.054 0.14 -10000 0 -10000 0 0
BAD 0.023 0.058 0.37 6 -10000 0 6
MAP2K4 -0.018 0.11 -10000 0 -0.44 3 3
SHP2/GRB2/SOS1/GAB1 -0.12 0.13 -10000 0 -0.57 2 2
INPPL1 0.017 0 -10000 0 -10000 0 0
PXN 0.017 0 -10000 0 -10000 0 0
SH3KBP1 0.005 0.086 -10000 0 -0.63 4 4
HGS -0.078 0.12 -10000 0 -10000 0 0
PLCgamma1/PKC -0.037 0.14 -10000 0 -0.55 15 15
HGF 0.01 0.07 -10000 0 -0.72 2 2
RASA1 0.01 0.07 -10000 0 -0.72 2 2
NCK1 0.017 0 -10000 0 -10000 0 0
PTPRJ 0.017 0 -10000 0 -10000 0 0
NCK/PLCgamma1 -0.093 0.16 -10000 0 -0.52 15 15
PDPK1 0.002 0.073 0.44 6 -10000 0 6
HGF/MET/SHIP -0.22 0.23 -10000 0 -0.47 103 103
HIF-2-alpha transcription factor network

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 -0.041 0.14 -10000 0 -0.64 9 9
oxygen homeostasis -0.014 0.014 -10000 0 -10000 0 0
TCEB2 0.017 0 -10000 0 -10000 0 0
TCEB1 0.01 0.07 -10000 0 -0.72 2 2
VHL/Elongin B/Elongin C/HIF2A -0.14 0.16 -10000 0 -0.48 11 11
EPO -0.27 0.25 -10000 0 -0.72 23 23
FIH (dimer) 0.002 0.009 -10000 0 -10000 0 0
APEX1 0.002 0.013 -10000 0 -10000 0 0
SERPINE1 -0.38 0.37 -10000 0 -0.99 41 41
FLT1 -0.031 0.14 -10000 0 -0.61 11 11
ADORA2A -0.31 0.29 -10000 0 -0.84 28 28
germ cell development -0.31 0.29 -10000 0 -0.82 30 30
SLC11A2 -0.36 0.34 -10000 0 -0.86 48 48
BHLHE40 -0.34 0.3 -10000 0 -0.79 42 42
HIF1AN 0.002 0.008 -10000 0 -10000 0 0
HIF2A/ARNT/SIRT1 -0.21 0.17 -10000 0 -0.48 42 42
ETS1 0.037 0.008 -10000 0 -10000 0 0
CITED2 -0.016 0.049 -10000 0 -10000 0 0
KDR -0.008 0.043 -10000 0 -10000 0 0
PGK1 -0.34 0.32 -10000 0 -0.92 30 30
SIRT1 0.017 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT -0.39 0.38 -10000 0 -0.98 42 42
EPAS1 -0.18 0.17 -10000 0 -0.44 42 42
SP1 0.026 0.006 -10000 0 -10000 0 0
ABCG2 -0.67 0.31 -10000 0 -0.9 108 108
EFNA1 -0.32 0.3 -10000 0 -0.87 28 28
FXN -0.31 0.3 -10000 0 -0.84 29 29
POU5F1 -0.33 0.31 -10000 0 -0.87 30 30
neuron apoptosis 0.38 0.36 0.93 42 -10000 0 42
EP300 0.017 0 -10000 0 -10000 0 0
EGLN3 -0.25 0.32 -10000 0 -0.64 86 86
EGLN2 0.004 0.01 -10000 0 -10000 0 0
EGLN1 0.002 0.008 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C -0.006 0.052 -10000 0 -0.46 3 3
VHL 0.014 0.049 -10000 0 -0.72 1 1
ARNT 0.002 0.013 -10000 0 -10000 0 0
SLC2A1 -0.35 0.34 -10000 0 -0.88 44 44
TWIST1 -0.36 0.36 -10000 0 -0.95 42 42
ELK1 0.014 0.098 -10000 0 -0.71 4 4
HIF2A/ARNT/Cbp/p300 -0.21 0.17 -10000 0 -0.54 17 17
VEGFA -0.35 0.34 -10000 0 -0.89 41 41
CREBBP 0.017 0 -10000 0 -10000 0 0
Glucocorticoid receptor regulatory network

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.039 0.12 -10000 0 -0.76 1 1
SMARCC2 0.017 0 -10000 0 -10000 0 0
SMARCC1 0.004 0.098 -10000 0 -0.72 4 4
TBX21 -0.35 0.45 -10000 0 -0.93 80 80
SUMO2 0.017 0.007 -10000 0 -10000 0 0
STAT1 (dimer) -0.038 0.21 -10000 0 -0.72 20 20
FKBP4 0.01 0.07 -10000 0 -0.72 2 2
FKBP5 0.017 0 -10000 0 -10000 0 0
GR alpha/HSP90/FKBP51/HSP90 0.11 0.18 0.36 19 -0.41 1 20
PRL -0.047 0.14 -10000 0 -0.77 1 1
cortisol/GR alpha (dimer)/TIF2 0.29 0.29 0.6 73 -10000 0 73
RELA -0.11 0.073 -10000 0 -10000 0 0
FGG 0.22 0.24 0.59 27 -10000 0 27
GR beta/TIF2 0.11 0.2 0.39 20 -0.45 8 28
IFNG -0.35 0.36 -10000 0 -0.85 60 60
apoptosis 0.068 0.14 0.58 4 -10000 0 4
CREB1 0.029 0.001 -10000 0 -10000 0 0
histone acetylation -0.072 0.14 -10000 0 -0.39 13 13
BGLAP -0.081 0.16 -10000 0 -0.59 1 1
GR/PKAc 0 0.24 0.36 9 -0.61 9 18
NF kappa B1 p50/RelA -0.21 0.14 -10000 0 -0.51 9 9
SMARCD1 0.017 0 -10000 0 -10000 0 0
MDM2 0.12 0.093 0.31 25 -10000 0 25
GATA3 0.029 0.027 -10000 0 -10000 0 0
AKT1 0.001 0.018 -10000 0 -10000 0 0
CSF2 -0.29 0.28 -10000 0 -0.61 71 71
GSK3B 0.014 0.05 -10000 0 -0.72 1 1
NR1I3 0.096 0.12 0.55 4 -10000 0 4
CSN2 0.18 0.19 0.47 19 -10000 0 19
BRG1/BAF155/BAF170/BAF60A -0.007 0.054 -10000 0 -0.41 4 4
NFATC1 0.026 0.05 -10000 0 -0.7 1 1
POU2F1 0.027 0.009 -10000 0 -10000 0 0
CDKN1A 0.005 0.19 -10000 0 -1.5 3 3
response to stress 0 0 -10000 0 -10000 0 0
response to UV 0.001 0.007 -10000 0 -10000 0 0
SFN 0.011 0.061 -10000 0 -0.63 2 2
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.11 0.17 0.35 18 -0.67 1 19
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 0.069 0.21 0.53 4 -0.87 7 11
JUN -0.18 0.2 -10000 0 -0.61 21 21
IL4 -0.086 0.17 -10000 0 -0.81 2 2
CDK5R1 0.017 0.005 -10000 0 -10000 0 0
PRKACA 0.017 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.072 0.27 -10000 0 -0.6 16 16
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.11 0.17 0.35 18 -10000 0 18
cortisol/GR alpha (monomer) 0.34 0.36 0.73 73 -0.52 1 74
NCOA2 0.017 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.13 0.23 -10000 0 -0.68 33 33
AP-1/NFAT1-c-4 -0.32 0.28 -10000 0 -0.77 36 36
AFP -0.11 0.16 -10000 0 -0.88 1 1
SUV420H1 0.017 0 -10000 0 -10000 0 0
IRF1 0.15 0.21 0.51 13 -1 2 15
TP53 0.01 0.15 -10000 0 -0.63 12 12
PPP5C 0.014 0.049 -10000 0 -0.72 1 1
KRT17 -0.28 0.29 -10000 0 -0.84 28 28
KRT14 -0.13 0.17 -10000 0 -0.88 3 3
TBP 0.029 0.001 -10000 0 -10000 0 0
CREBBP 0.03 0.031 -10000 0 -10000 0 0
HDAC1 0.009 0.031 -10000 0 -10000 0 0
HDAC2 0.041 0.025 -10000 0 -10000 0 0
AP-1 -0.32 0.28 -10000 0 -0.77 37 37
MAPK14 0.017 0.006 -10000 0 -10000 0 0
MAPK10 0.005 0.092 -10000 0 -0.68 4 4
MAPK11 0.014 0.05 -10000 0 -0.72 1 1
KRT5 -0.26 0.26 -10000 0 -0.76 26 26
interleukin-1 receptor activity 0.025 0.026 -10000 0 -10000 0 0
NCOA1 0.015 0.062 -10000 0 -0.63 2 2
STAT1 -0.038 0.21 -10000 0 -0.72 20 20
CGA -0.081 0.16 -10000 0 -0.59 1 1
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.19 0.23 0.44 78 -10000 0 78
MAPK3 0.011 0.061 -10000 0 -0.63 2 2
MAPK1 0.014 0.044 -10000 0 -0.63 1 1
ICAM1 -0.32 0.32 -10000 0 -0.82 42 42
NFKB1 -0.11 0.073 -10000 0 -10000 0 0
MAPK8 -0.17 0.2 -10000 0 -0.57 23 23
MAPK9 0.017 0.006 -10000 0 -10000 0 0
cortisol/GR alpha (dimer) 0.046 0.14 0.58 4 -10000 0 4
BAX 0.019 0.087 -10000 0 -10000 0 0
POMC -0.13 0.19 -10000 0 -1.3 1 1
EP300 0.036 0.036 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/p53 0.28 0.32 0.62 71 -0.66 1 72
proteasomal ubiquitin-dependent protein catabolic process 0.085 0.07 0.26 5 -10000 0 5
SGK1 0.082 0.072 0.32 3 -10000 0 3
IL13 -0.2 0.23 -10000 0 -0.89 9 9
IL6 -0.49 0.44 -10000 0 -0.92 104 104
PRKACG 0.017 0 -10000 0 -10000 0 0
IL5 -0.21 0.25 -10000 0 -0.82 20 20
IL2 -0.26 0.25 -10000 0 -0.77 19 19
CDK5 0.01 0.07 -10000 0 -0.72 2 2
PRKACB -0.16 0.29 -10000 0 -0.63 60 60
HSP90AA1 0.014 0.049 -10000 0 -0.72 1 1
IL8 -0.69 0.32 -10000 0 -0.8 175 175
CDK5R1/CDK5 -0.003 0.052 -10000 0 -0.54 2 2
NF kappa B1 p50/RelA/PKAc -0.21 0.2 -10000 0 -0.59 29 29
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.28 0.28 0.58 65 -10000 0 65
SMARCA4 0.017 0 -10000 0 -10000 0 0
chromatin remodeling 0.18 0.19 0.41 46 -0.53 3 49
NF kappa B1 p50/RelA/Cbp -0.12 0.1 -10000 0 -0.52 1 1
JUN (dimer) -0.18 0.2 -10000 0 -0.61 21 21
YWHAH 0.017 0 -10000 0 -10000 0 0
VIPR1 -0.19 0.36 -10000 0 -1.1 29 29
NR3C1 0.16 0.3 0.52 44 -0.55 21 65
NR4A1 0.018 0.084 -10000 0 -0.7 3 3
TIF2/SUV420H1 0 0 -10000 0 -10000 0 0
MAPKKK cascade 0.068 0.14 0.58 4 -10000 0 4
cortisol/GR alpha (dimer)/Src-1 0.3 0.3 0.6 73 -10000 0 73
PBX1 0.015 0.087 -10000 0 -0.62 4 4
POU1F1 0.024 0.044 -10000 0 -0.62 1 1
SELE -0.4 0.4 -10000 0 -0.99 58 58
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.18 0.2 0.42 46 -0.54 3 49
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.28 0.28 0.58 65 -10000 0 65
mol:cortisol 0.22 0.19 0.44 73 -10000 0 73
MMP1 -0.55 0.22 -10000 0 -0.63 191 191
Presenilin action in Notch and Wnt signaling

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) -0.001 0.007 -10000 0 -10000 0 0
HDAC1 0.028 0.022 -10000 0 -10000 0 0
AES 0.021 0.006 -10000 0 -10000 0 0
FBXW11 0.017 0 -10000 0 -10000 0 0
DTX1 0.017 0 -10000 0 -10000 0 0
LRP6/FZD1 -0.002 0.036 -10000 0 -0.54 1 1
TLE1 0.02 0.006 -10000 0 -10000 0 0
AP1 -0.24 0.2 -10000 0 -0.57 39 39
NCSTN 0.017 0 -10000 0 -10000 0 0
ADAM10 0.018 0.001 -10000 0 -10000 0 0
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.048 0.1 -10000 0 -10000 0 0
NICD/RBPSUH -0.002 0.008 -10000 0 -10000 0 0
WIF1 -0.096 0.26 -10000 0 -0.72 34 34
NOTCH1 -0.002 0.01 -10000 0 -10000 0 0
PSENEN 0.017 0 -10000 0 -10000 0 0
KREMEN2 -0.12 0.29 -10000 0 -0.72 43 43
DKK1 -0.17 0.32 -10000 0 -0.72 56 56
beta catenin/beta TrCP1 0.12 0.085 -10000 0 -10000 0 0
APH1B 0.013 0.049 -10000 0 -0.72 1 1
APH1A -0.007 0.12 -10000 0 -0.64 8 8
AXIN1 -0.045 0.039 0.29 1 -10000 0 1
CtBP/CBP/TCF1/TLE1/AES 0.094 0.073 -10000 0 -10000 0 0
PSEN1 0.017 0 -10000 0 -10000 0 0
FOS -0.08 0.23 -10000 0 -0.64 33 33
JUN 0 0.11 -10000 0 -0.72 5 5
MAP3K7 0.024 0.008 -10000 0 -10000 0 0
CTNNB1 0.11 0.091 0.28 1 -10000 0 1
MAPK3 0.011 0.061 -10000 0 -0.63 2 2
DKK2/LRP6/Kremen 2 -0.27 0.28 -10000 0 -0.52 115 115
HNF1A 0.021 0.006 -10000 0 -10000 0 0
CTBP1 0.021 0.006 -10000 0 -10000 0 0
MYC -0.32 0.29 -10000 0 -0.57 133 133
NKD1 -0.54 0.32 -10000 0 -0.72 169 169
FZD1 0.017 0 -10000 0 -10000 0 0
NOTCH1 precursor/Deltex homolog 1 -0.002 0.008 -10000 0 -10000 0 0
apoptosis -0.23 0.2 -10000 0 -0.57 39 39
Delta 1/NOTCHprecursor -0.002 0.008 -10000 0 -10000 0 0
DLL1 0.017 0 -10000 0 -10000 0 0
PPARD -0.012 0.04 -10000 0 -10000 0 0
Gamma Secretase -0.013 0.064 -10000 0 -10000 0 0
APC -0.066 0.1 0.29 1 -0.51 10 11
DVL1 -0.009 0.021 -10000 0 -10000 0 0
CSNK2A1 0.008 0.008 -10000 0 -10000 0 0
MAP3K7IP1 0.024 0.008 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 -0.2 0.26 -10000 0 -0.51 89 89
LRP6 0.013 0.049 -10000 0 -0.72 1 1
CSNK1A1 0.008 0.008 -10000 0 -10000 0 0
NLK 0.052 0.019 -10000 0 -10000 0 0
CCND1 -0.096 0.22 -10000 0 -0.6 35 35
WNT1 0.017 0 -10000 0 -10000 0 0
Axin1/APC/beta catenin 0.058 0.077 0.35 1 -10000 0 1
DKK2 -0.28 0.36 -10000 0 -0.72 89 89
NOTCH1 precursor/DVL1 -0.002 0.009 -10000 0 -10000 0 0
GSK3B 0.016 0.049 -10000 0 -0.72 1 1
FRAT1 0.018 0.044 -10000 0 -0.63 1 1
NOTCH/Deltex homolog 1 -0.001 0.007 -10000 0 -10000 0 0
PPP2R5D 0.24 0.14 0.31 169 -10000 0 169
MAPK1 0.014 0.043 -10000 0 -0.63 1 1
WNT1/LRP6/FZD1 -0.064 0.15 -10000 0 -0.41 35 35
RBPJ 0.017 0 -10000 0 -10000 0 0
CREBBP 0.008 0.01 -10000 0 -10000 0 0
IL1-mediated signaling events

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
MAP3K7IP2 0.017 0 -10000 0 -10000 0 0
ERC1 0.017 0 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.051 0.087 -10000 0 -0.37 4 4
IRAK/TOLLIP 0.03 0.043 -10000 0 -0.42 2 2
IKBKB 0.014 0.049 -10000 0 -0.72 1 1
IKBKG 0.017 0 -10000 0 -10000 0 0
IL1 alpha/IL1R2 -0.41 0.29 -10000 0 -0.57 163 163
IL1A -0.32 0.37 -10000 0 -0.72 101 101
IL1B -0.11 0.25 -10000 0 -0.54 55 55
IRAK/TRAF6/p62/Atypical PKCs -0.013 0.065 -10000 0 -10000 0 0
IL1R2 -0.24 0.32 -10000 0 -0.63 88 88
IL1R1 -0.006 0.12 -10000 0 -0.63 8 8
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.042 0.078 0.2 2 -10000 0 2
TOLLIP 0.017 0 -10000 0 -10000 0 0
TICAM2 0 0 -10000 0 -10000 0 0
MAP3K3 0.017 0 -10000 0 -10000 0 0
TAK1/TAB1/TAB2 0 0 -10000 0 -10000 0 0
IKK complex/ELKS 0.082 0.035 -10000 0 -10000 0 0
JUN 0.056 0.082 -10000 0 -10000 0 0
MAP3K7 0.017 0 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.11 0.18 -10000 0 -0.74 6 6
IL1 alpha/IL1R1/IL1RAP/MYD88 -0.21 0.22 -10000 0 -0.43 102 102
PIK3R1 0.017 0 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 -0.19 0.21 -10000 0 -0.77 6 6
IL1 beta fragment/IL1R1/IL1RAP -0.12 0.21 -10000 0 -0.46 47 47
NFKB1 0.017 0 -10000 0 -10000 0 0
MAPK8 0.056 0.064 -10000 0 -10000 0 0
IRAK1 0.021 0.046 -10000 0 -0.47 2 2
IL1RN/IL1R1 -0.17 0.25 -10000 0 -0.53 72 72
IRAK4 0.017 0 -10000 0 -10000 0 0
PRKCI -0.003 0.12 -10000 0 -0.72 6 6
TRAF6 0.017 0 -10000 0 -10000 0 0
PI3K 0 0 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.02 0.12 -10000 0 -0.37 6 6
CHUK 0.017 0 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.12 0.21 -10000 0 -0.46 47 47
IL1 beta/IL1R2 -0.26 0.26 -10000 0 -0.58 52 52
IRAK/TRAF6/TAK1/TAB1/TAB2 -0.003 0.032 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.094 0.16 -10000 0 -0.66 6 6
IRAK3 -0.009 0.14 -10000 0 -0.72 8 8
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.11 0.18 -10000 0 -0.75 6 6
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.082 0.14 -10000 0 -0.43 6 6
IL1 alpha/IL1R1/IL1RAP -0.23 0.25 -10000 0 -0.47 109 109
RELA 0.017 0 -10000 0 -10000 0 0
MAP3K7IP1 0.017 0 -10000 0 -10000 0 0
SQSTM1 0.017 0 -10000 0 -10000 0 0
MYD88 0.017 0 -10000 0 -10000 0 0
IRAK/TRAF6/MEKK3 -0.003 0.036 -10000 0 -10000 0 0
IL1RAP -0.003 0.12 -10000 0 -0.72 6 6
UBE2N 0.017 0 -10000 0 -10000 0 0
IRAK/TRAF6 -0.091 0.15 -10000 0 -0.61 7 7
CASP1 -0.032 0.18 -10000 0 -0.67 16 16
IL1RN/IL1R2 -0.33 0.26 -10000 0 -0.52 144 144
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.11 0.19 -10000 0 -0.78 6 6
TMEM189-UBE2V1 0 0 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.051 0.12 -10000 0 -0.38 6 6
PIK3CA 0.017 0 -10000 0 -10000 0 0
IL1RN -0.19 0.33 -10000 0 -0.72 64 64
TRAF6/TAK1/TAB1/TAB2 0 0 -10000 0 -10000 0 0
MAP2K6 0.047 0.067 -10000 0 -10000 0 0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.023 0.026 -10000 0 -10000 0 0
NFATC2 -0.006 0.17 -10000 0 -1 1 1
NFATC3 -0.023 0.093 -10000 0 -10000 0 0
CD40LG -0.52 0.39 -10000 0 -0.99 64 64
ITCH 0.055 0.049 -10000 0 -10000 0 0
CBLB 0.055 0.049 -10000 0 -10000 0 0
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.19 0.22 -10000 0 -0.84 10 10
JUNB 0.007 0.085 -10000 0 -0.72 3 3
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.009 0.048 -10000 0 -10000 0 0
T cell anergy 0.076 0.084 -10000 0 -0.46 1 1
TLE4 0.016 0.14 -10000 0 -1.2 1 1
Jun/NFAT1-c-4/p21SNFT -0.21 0.27 -10000 0 -0.87 19 19
AP-1/NFAT1-c-4 -0.59 0.49 -10000 0 -1.1 73 73
IKZF1 0.008 0.17 -10000 0 -0.96 4 4
T-helper 2 cell differentiation -0.086 0.14 -10000 0 -0.76 2 2
AP-1/NFAT1 -0.16 0.21 -10000 0 -0.61 27 27
CALM1 0.03 0.031 -10000 0 -10000 0 0
EGR2 -0.084 0.36 -10000 0 -1.4 11 11
EGR3 -0.087 0.34 -10000 0 -1.1 12 12
NFAT1/FOXP3 0.017 0.12 -10000 0 -0.79 1 1
EGR1 -0.014 0.15 -10000 0 -0.66 11 11
JUN -0.048 0.11 -10000 0 -0.76 5 5
EGR4 0.002 0.001 -10000 0 -10000 0 0
mol:Ca2+ 0.014 0.034 -10000 0 -10000 0 0
GBP3 -0.1 0.35 -10000 0 -0.82 41 41
FOSL1 -0.026 0.17 -10000 0 -0.72 13 13
NFAT1-c-4/MAF/IRF4 -0.28 0.37 -10000 0 -1 29 29
DGKA 0.018 0.12 -10000 0 -0.79 1 1
CREM 0.016 0.001 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.12 0.26 -10000 0 -0.84 16 16
CTLA4 0.019 0.13 -10000 0 -0.67 4 4
NFAT1-c-4 (dimer)/EGR1 -0.12 0.29 -10000 0 -0.96 14 14
NFAT1-c-4 (dimer)/EGR4 -0.11 0.26 -10000 0 -0.85 15 15
FOS -0.13 0.24 -10000 0 -0.69 33 33
IFNG -0.32 0.32 -10000 0 -0.73 49 49
T cell activation -0.14 0.17 -10000 0 -0.71 3 3
MAF -0.21 0.31 -10000 0 -0.63 79 79
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.057 0.21 0.66 10 -10000 0 10
TNF -0.085 0.26 -10000 0 -0.87 11 11
FASLG -0.22 0.54 -10000 0 -1.4 31 31
TBX21 -0.19 0.29 -10000 0 -0.63 68 68
BATF3 0 0 -10000 0 -10000 0 0
PRKCQ -0.004 0.12 -10000 0 -0.73 6 6
PTPN1 0.018 0.12 -10000 0 -0.79 1 1
NFAT1-c-4/ICER1 -0.11 0.25 -10000 0 -0.86 14 14
GATA3 0.022 0.002 -10000 0 -10000 0 0
T-helper 1 cell differentiation -0.32 0.32 -10000 0 -0.72 49 49
IL2RA -0.2 0.21 -10000 0 -0.77 12 12
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 0.015 0.13 -10000 0 -0.8 2 2
E2F1 -0.031 0.18 -10000 0 -0.71 14 14
PPARG 0 0.1 -10000 0 -0.63 6 6
SLC3A2 -0.005 0.18 -10000 0 -0.64 11 11
IRF4 -0.13 0.27 -10000 0 -0.63 51 51
PTGS2 -0.61 0.48 -10000 0 -1.1 86 86
CSF2 -0.69 0.49 -10000 0 -1.1 108 108
JunB/Fra1/NFAT1-c-4 -0.12 0.26 -10000 0 -0.85 11 11
IL4 -0.088 0.14 -10000 0 -0.8 2 2
IL5 -0.54 0.41 -10000 0 -1 70 70
IL2 -0.14 0.17 -10000 0 -0.72 3 3
IL3 -0.056 0.052 -10000 0 -10000 0 0
RNF128 0.038 0.13 -10000 0 -0.67 7 7
NFATC1 -0.057 0.21 -10000 0 -0.66 10 10
CDK4 -0.003 0.21 -10000 0 -0.65 5 5
PTPRK 0.018 0.12 -10000 0 -0.79 1 1
IL8 -0.84 0.4 -10000 0 -1.1 121 121
POU2F1 0.028 0 -10000 0 -10000 0 0
EGFR-dependent Endothelin signaling events

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.017 0 -9999 0 -10000 0 0
EGFR 0.002 0.099 -9999 0 -0.65 5 5
EGF/EGFR -0.21 0.22 -9999 0 -0.44 82 82
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.11 0.16 -9999 0 -0.71 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA -0.15 0.31 -9999 0 -0.72 50 50
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF -0.18 0.31 -9999 0 -0.67 65 65
EGF/EGFR dimer/SHC -0.13 0.2 -9999 0 -0.47 30 30
mol:GDP -0.1 0.16 -9999 0 -0.7 1 1
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 -0.022 0.16 -9999 0 -0.65 13 13
GRB2/SOS1 0 0 -9999 0 -10000 0 0
HRAS/GTP -0.095 0.14 -9999 0 -0.65 1 1
SHC1 0.017 0 -9999 0 -10000 0 0
HRAS/GDP -0.096 0.15 -9999 0 -0.66 1 1
FRAP1 -0.054 0.18 -9999 0 -0.67 1 1
EGF/EGFR dimer -0.15 0.23 -9999 0 -0.5 69 69
SOS1 0.017 0 -9999 0 -10000 0 0
GRB2 0.017 0 -9999 0 -10000 0 0
ETA receptor/Endothelin-1 -0.15 0.24 -9999 0 -0.53 62 62
Aurora A signaling

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A -0.001 0.11 -9999 0 -0.44 3 3
BIRC5 -0.059 0.22 -9999 0 -0.72 23 23
NFKBIA 0.009 0.099 -9999 0 -0.42 1 1
CPEB1 -0.021 0.15 -9999 0 -0.63 13 13
AKT1 0.009 0.099 -9999 0 -0.42 1 1
NDEL1 0.017 0 -9999 0 -10000 0 0
Aurora A/BRCA1 -0.027 0.1 -9999 0 -0.5 5 5
NDEL1/TACC3 -0.021 0.088 -9999 0 -0.48 2 2
GADD45A 0.01 0.07 -9999 0 -0.72 2 2
GSK3B 0.017 0.05 -9999 0 -0.71 1 1
PAK1/Aurora A 0.003 0.096 -9999 0 -0.42 1 1
MDM2 0.017 0 -9999 0 -10000 0 0
JUB -0.69 0.16 -9999 0 -0.72 213 213
TPX2 -0.12 0.25 -9999 0 -0.54 60 60
TP53 0.01 0.084 -9999 0 -0.36 3 3
DLG7 -0.024 0.15 -9999 0 -0.47 16 16
AURKAIP1 0.017 0 -9999 0 -10000 0 0
ARHGEF7 0.017 0 -9999 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0 -9999 0 -10000 0 0
Aurora A/NDEL1/TACC3 -0.022 0.094 -9999 0 -0.5 2 2
G2/M transition of mitotic cell cycle -0.027 0.1 -9999 0 -0.49 5 5
AURKA -0.004 0.12 -9999 0 -0.5 1 1
AURKB -0.02 0.038 -9999 0 -0.2 1 1
CDC25B -0.24 0.14 -9999 0 -0.39 83 83
G2/M transition checkpoint -0.42 0.12 -9999 0 -0.44 213 213
mRNA polyadenylation -0.04 0.12 -9999 0 -0.38 14 14
Aurora A/CPEB -0.04 0.12 -9999 0 -0.38 14 14
Aurora A/TACC1/TRAP/chTOG -0.012 0.072 -9999 0 -10000 0 0
BRCA1 0.004 0.098 -9999 0 -0.72 4 4
centrosome duplication 0.003 0.096 -9999 0 -0.42 1 1
regulation of centrosome cycle -0.021 0.087 -9999 0 -0.47 2 2
spindle assembly -0.012 0.072 -9999 0 -10000 0 0
TDRD7 0.017 0 -9999 0 -10000 0 0
Aurora A/RasGAP/Survivin -0.062 0.16 -9999 0 -0.63 8 8
CENPA -0.035 0.065 -9999 0 -0.24 13 13
Aurora A/PP2A 0.003 0.096 -9999 0 -0.42 1 1
meiosis 0 0 -9999 0 -10000 0 0
protein catabolic process 0.008 0.11 -9999 0 -0.38 3 3
negative regulation of DNA binding 0.01 0.083 -9999 0 -0.36 3 3
prophase 0 0 -9999 0 -10000 0 0
GIT1/beta-PIX 0 0 -9999 0 -10000 0 0
RASA1 0.01 0.07 -9999 0 -0.72 2 2
Ajuba/Aurora A -0.42 0.12 -9999 0 -0.44 213 213
mitotic prometaphase -0.002 0.004 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process -0.004 0.12 -9999 0 -0.5 1 1
TACC1 0.017 0 -9999 0 -10000 0 0
TACC3 0.007 0.085 -9999 0 -0.72 3 3
Aurora A/Antizyme1 -0.016 0.079 -9999 0 -0.37 1 1
Aurora A/RasGAP -0.001 0.11 -9999 0 -0.44 3 3
OAZ1 0.017 0 -9999 0 -10000 0 0
RAN 0.014 0.049 -9999 0 -0.72 1 1
mitosis 0 0 -9999 0 -10000 0 0
PRKACA 0.021 0.011 -9999 0 -10000 0 0
GIT1 0.017 0 -9999 0 -10000 0 0
GIT1/beta-PIX/PAK1 0 0 -9999 0 -10000 0 0
Importin alpha/Importin beta/TPX2 -0.12 0.25 -9999 0 -0.54 60 60
PPP2R5D 0.017 0 -9999 0 -10000 0 0
Aurora A/TPX2 -0.1 0.24 -9999 0 -0.5 50 50
PAK1 0.017 0 -9999 0 -10000 0 0
CKAP5 0.017 0 -9999 0 -10000 0 0
TRAIL signaling pathway

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 -0.041 0.18 -9999 0 -0.63 20 20
positive regulation of NF-kappaB transcription factor activity -0.05 0.15 -9999 0 -0.49 23 23
MAP2K4 0.003 0.12 -9999 0 -0.51 4 4
IKBKB 0.014 0.049 -9999 0 -0.72 1 1
TNFRSF10B -0.085 0.26 -9999 0 -0.72 31 31
TNFRSF10A -0.056 0.22 -9999 0 -0.72 22 22
SMPD1 -0.15 0.23 -9999 0 -0.52 50 50
IKBKG 0.017 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
TNFRSF10D 0.004 0.098 -9999 0 -0.72 4 4
TRAIL/TRAILR2 -0.11 0.23 -9999 0 -0.55 46 46
TRAIL/TRAILR3 -0.1 0.21 -9999 0 -0.52 44 44
TRAIL/TRAILR1 -0.093 0.21 -9999 0 -0.53 39 39
TRAIL/TRAILR4 -0.05 0.15 -9999 0 -0.49 23 23
TRAIL/TRAILR1/DAP3/GTP -0.072 0.16 -9999 0 -0.42 39 39
IKK complex -0.033 0.063 -9999 0 -10000 0 0
RIPK1 0.017 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
DAP3/GTP 0 0 -9999 0 -10000 0 0
MAPK3 -0.016 0.15 -9999 0 -0.48 21 21
MAP3K1 -0.044 0.095 -9999 0 -0.42 6 6
TRAILR4 (trimer) 0.004 0.098 -9999 0 -0.72 4 4
TRADD 0.017 0 -9999 0 -10000 0 0
TRAILR1 (trimer) -0.056 0.22 -9999 0 -0.72 22 22
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 -0.001 0.12 -9999 0 -0.49 3 3
CFLAR 0.017 0 -9999 0 -10000 0 0
MAPK1 -0.015 0.14 -9999 0 -0.46 21 21
TRAIL/TRAILR1/FADD/TRADD/RIP -0.065 0.15 -9999 0 -0.71 3 3
mol:ceramide -0.15 0.23 -9999 0 -0.51 50 50
FADD 0.017 0 -9999 0 -10000 0 0
MAPK8 0.013 0.12 -9999 0 -0.48 4 4
TRAF2 0.017 0 -9999 0 -10000 0 0
TRAILR3 (trimer) -0.069 0.24 -9999 0 -0.72 26 26
CHUK 0.017 0 -9999 0 -10000 0 0
TRAIL/TRAILR1/FADD -0.079 0.18 -9999 0 -0.45 39 39
DAP3 0.017 0 -9999 0 -10000 0 0
CASP10 -0.081 0.16 -9999 0 -0.59 10 10
JNK cascade -0.05 0.15 -9999 0 -0.49 23 23
TRAIL (trimer) -0.041 0.18 -9999 0 -0.63 20 20
TNFRSF10C -0.069 0.24 -9999 0 -0.72 26 26
TRAIL/TRAILR1/DAP3/GTP/FADD -0.067 0.15 -9999 0 -0.72 3 3
TRAIL/TRAILR2/FADD -0.097 0.2 -9999 0 -0.51 31 31
cell death -0.15 0.23 -9999 0 -0.51 50 50
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 -0.012 0.13 -9999 0 -0.49 5 5
TRAILR2 (trimer) -0.085 0.26 -9999 0 -0.72 31 31
CASP8 0.013 0.044 -9999 0 -10000 0 0
negative regulation of caspase activity 0 0 -9999 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP -0.08 0.17 -9999 0 -0.71 5 5
Calcium signaling in the CD4+ TCR pathway

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.004 0.055 -9999 0 -0.5 1 1
NFATC2 -0.002 0.044 -9999 0 -10000 0 0
NFATC3 -0.002 0.044 -9999 0 -10000 0 0
CD40LG -0.21 0.33 -9999 0 -0.74 38 38
PTGS2 -0.3 0.43 -9999 0 -0.86 68 68
JUNB 0.007 0.085 -9999 0 -0.72 3 3
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.013 0.016 -9999 0 -10000 0 0
CaM/Ca2+ -0.013 0.016 -9999 0 -10000 0 0
CALM1 0.01 0.012 -9999 0 -10000 0 0
JUN -0.005 0.11 -9999 0 -0.72 5 5
mol:Ca2+ -0.017 0.015 -9999 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0 0.004 -9999 0 -10000 0 0
FOSL1 -0.026 0.17 -9999 0 -0.72 13 13
CREM 0.016 0 -9999 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT -0.12 0.13 -9999 0 -0.55 3 3
FOS -0.086 0.23 -9999 0 -0.65 33 33
IFNG -0.28 0.41 -9999 0 -0.87 53 53
AP-1/NFAT1-c-4 -0.26 0.4 -9999 0 -0.92 38 38
FASLG -0.24 0.35 -9999 0 -0.76 44 44
NFAT1-c-4/ICER1 -0.055 0.068 -9999 0 -0.44 1 1
IL2RA -0.21 0.34 -9999 0 -0.77 39 39
FKBP12/FK506 0 0 -9999 0 -10000 0 0
CSF2 -0.38 0.45 -9999 0 -0.85 89 89
JunB/Fra1/NFAT1-c-4 -0.069 0.13 -9999 0 -0.57 9 9
IL4 -0.21 0.33 -9999 0 -0.73 38 38
IL2 0.011 0.013 -9999 0 -10000 0 0
IL3 0.001 0.02 -9999 0 -10000 0 0
FKBP1A 0.017 0 -9999 0 -10000 0 0
BATF3 0 0 -9999 0 -10000 0 0
mol:FK506 0 0 -9999 0 -10000 0 0
POU2F1 0.028 0 -9999 0 -10000 0 0
IL12-mediated signaling events

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 0.032 0.097 -10000 0 -0.38 1 1
TBX21 -0.34 0.69 -10000 0 -1.4 68 68
B2M -0.01 0.13 -10000 0 -0.63 10 10
TYK2 0.019 0.021 -10000 0 -10000 0 0
IL12RB1 0.019 0.021 -10000 0 -10000 0 0
GADD45B -0.095 0.37 -10000 0 -0.9 25 25
IL12RB2 0.017 0.057 -10000 0 -0.77 1 1
GADD45G -0.1 0.37 -10000 0 -0.9 27 27
natural killer cell activation -0.001 0.028 -10000 0 -10000 0 0
RELB 0.017 0 -10000 0 -10000 0 0
RELA 0.017 0 -10000 0 -10000 0 0
IL18 -0.052 0.21 -10000 0 -0.64 25 25
IL2RA -0.006 0.13 -10000 0 -0.72 7 7
IFNG -0.15 0.31 -10000 0 -0.72 50 50
STAT3 (dimer) -0.06 0.33 -10000 0 -0.76 24 24
HLA-DRB5 -0.005 0.11 -10000 0 -0.63 7 7
FASLG -0.16 0.52 -10000 0 -1.4 27 27
NF kappa B2 p52/RelB -0.19 0.31 -10000 0 -0.83 33 33
CD4 0.016 0.007 -10000 0 -10000 0 0
SOCS1 0.014 0.049 -10000 0 -0.72 1 1
EntrezGene:6955 0 0.01 -10000 0 -10000 0 0
CD3D -0.011 0.14 -10000 0 -0.63 10 10
CD3E 0.018 0.008 -10000 0 -10000 0 0
CD3G -0.014 0.14 -10000 0 -0.65 11 11
IL12Rbeta2/JAK2 0.018 0.094 -10000 0 -0.55 5 5
CCL3 -0.11 0.39 -10000 0 -0.95 23 23
CCL4 -0.11 0.41 -10000 0 -1 24 24
HLA-A 0.005 0.096 -10000 0 -0.63 5 5
IL18/IL18R -0.062 0.25 -10000 0 -0.46 51 51
NOS2 -0.12 0.39 -10000 0 -0.81 39 39
IL12/IL12R/TYK2/JAK2/SPHK2 0.031 0.095 -10000 0 -0.38 1 1
IL1R1 -0.13 0.43 -10000 0 -1 30 30
IL4 0.018 0.055 -10000 0 -0.71 1 1
JAK2 0.006 0.1 -10000 0 -0.72 4 4
EntrezGene:6957 0.001 0.009 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.003 0.2 -10000 0 -0.74 11 11
RAB7A -0.056 0.32 -10000 0 -0.82 15 15
lysosomal transport -0.05 0.31 -10000 0 -0.76 16 16
FOS -0.18 0.53 -10000 0 -1.2 40 40
STAT4 (dimer) -0.11 0.38 -10000 0 -0.86 30 30
STAT5A (dimer) -0.25 0.31 -10000 0 -0.78 42 42
GZMA -0.12 0.38 -10000 0 -0.8 37 37
GZMB -0.11 0.38 -10000 0 -0.93 26 26
HLX 0.017 0 -10000 0 -10000 0 0
LCK -0.12 0.41 -10000 0 -0.94 31 31
TCR/CD3/MHC II/CD4 -0.016 0.22 -10000 0 -0.64 17 17
IL2/IL2R -0.019 0.083 -10000 0 -10000 0 0
MAPK14 -0.092 0.38 -10000 0 -0.9 27 27
CCR5 -0.17 0.52 -10000 0 -1.3 30 30
IL1B -0.12 0.28 -10000 0 -0.71 41 41
STAT6 -0.006 0.12 -10000 0 -0.25 2 2
STAT4 0.014 0.043 -10000 0 -0.63 1 1
STAT3 0.017 0 -10000 0 -10000 0 0
STAT1 -0.049 0.21 -10000 0 -0.72 20 20
NFKB1 0.017 0 -10000 0 -10000 0 0
NFKB2 0.014 0.049 -10000 0 -0.72 1 1
IL12B 0.014 0.071 -10000 0 -0.7 2 2
CD8A 0.002 0.003 -10000 0 -10000 0 0
CD8B 0.019 0.002 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity -0.032 0.097 0.38 1 -10000 0 1
IL2RB 0.014 0.043 -10000 0 -0.63 1 1
proteasomal ubiquitin-dependent protein catabolic process -0.094 0.35 -10000 0 -0.77 30 30
IL2RG 0.008 0.075 -10000 0 -0.63 3 3
IL12 0.008 0.11 -10000 0 -0.51 9 9
STAT5A 0.017 0 -10000 0 -10000 0 0
CD247 -0.014 0.14 -10000 0 -0.64 11 11
IL2 0.017 0 -10000 0 -10000 0 0
SPHK2 0.014 0.043 -10000 0 -0.63 1 1
FRAP1 0.017 0 -10000 0 -10000 0 0
IL12A -0.003 0.13 -10000 0 -0.71 7 7
IL12/IL12R/TYK2/JAK2 -0.13 0.44 -10000 0 -0.94 36 36
MAP2K3 -0.096 0.38 -10000 0 -0.88 30 30
RIPK2 -0.12 0.29 -10000 0 -0.72 43 43
MAP2K6 -0.1 0.38 -10000 0 -0.87 31 31
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA 0.007 0.075 -10000 0 -0.63 3 3
IL18RAP -0.1 0.26 -10000 0 -0.64 43 43
IL12Rbeta1/TYK2 0.027 0.033 -10000 0 -10000 0 0
EOMES 0.023 0.065 -10000 0 -0.5 1 1
STAT1 (dimer) -0.14 0.32 -10000 0 -0.73 31 31
T cell proliferation -0.084 0.3 -10000 0 -0.65 28 28
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 0.018 0.045 -10000 0 -0.64 1 1
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.18 0.26 -10000 0 -0.72 32 32
ATF2 -0.072 0.35 -10000 0 -0.81 27 27
PLK1 signaling events

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion 0.003 0.048 0.21 11 -10000 0 11
BUB1B -0.097 0.15 -10000 0 -0.36 48 48
PLK1 -0.015 0.042 -10000 0 -0.13 10 10
PLK1S1 -0.008 0.021 -10000 0 -0.078 2 2
KIF2A -0.002 0.038 -10000 0 -10000 0 0
regulation of mitotic centrosome separation -0.015 0.042 -10000 0 -0.13 10 10
GOLGA2 0.017 0 -10000 0 -10000 0 0
Hec1/SPC24 -0.015 0.051 -10000 0 -0.46 2 2
WEE1 -0.051 0.079 -10000 0 -0.34 4 4
cytokinesis -0.033 0.13 -10000 0 -0.38 27 27
PP2A-alpha B56 -0.1 0.13 -10000 0 -0.5 3 3
AURKA -0.02 0.061 -10000 0 -0.17 31 31
PICH/PLK1 -0.38 0.36 -10000 0 -0.72 97 97
CENPE -0.019 0.1 -10000 0 -0.48 9 9
RhoA/GTP 0 0 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization -0.002 0.037 -10000 0 -10000 0 0
PPP2CA 0.017 0 -10000 0 -10000 0 0
FZR1 0.017 0 -10000 0 -10000 0 0
TPX2 -0.041 0.078 -10000 0 -0.17 59 59
PAK1 0.015 0.002 -10000 0 -10000 0 0
SPC24 0 0 -10000 0 -10000 0 0
FBXW11 0.017 0 -10000 0 -10000 0 0
CLSPN -0.005 0.038 -10000 0 -0.2 5 5
GORASP1 0.017 0 -10000 0 -10000 0 0
metaphase -0.001 0.002 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NLP -0.008 0.021 -10000 0 -0.078 2 2
G2 phase of mitotic cell cycle -0.003 0.004 -10000 0 -0.013 19 19
STAG2 -0.006 0.13 -10000 0 -0.72 7 7
GRASP65/GM130/RAB1/GTP -0.012 0.025 -10000 0 -10000 0 0
spindle elongation -0.015 0.042 -10000 0 -0.13 10 10
ODF2 0.01 0.049 -10000 0 -0.72 1 1
BUB1 -0.13 0.15 -10000 0 -0.56 3 3
TPT1 0 0.021 -10000 0 -10000 0 0
CDC25C -0.011 0.058 -10000 0 -0.23 13 13
CDC25B -0.34 0.37 -10000 0 -0.72 106 106
SGOL1 -0.003 0.048 -10000 0 -0.21 11 11
RHOA 0.017 0 -10000 0 -10000 0 0
CCNB1/CDK1 -0.26 0.26 -10000 0 -0.52 83 83
CDC14B 0.013 0.005 -10000 0 -10000 0 0
CDC20 -0.003 0.12 -10000 0 -0.72 6 6
PLK1/PBIP1 -0.05 0.13 -10000 0 -0.42 22 22
mitosis 0.002 0.013 0.033 31 -0.026 1 32
FBXO5 -0.04 0.087 -10000 0 -0.39 9 9
CDC2 -0.062 0.22 -10000 0 -0.73 21 21
NDC80 0.01 0.07 -10000 0 -0.72 2 2
metaphase plate congression -0.003 0.025 -10000 0 -10000 0 0
ERCC6L -0.38 0.33 -10000 0 -0.72 94 94
NLP/gamma Tubulin -0.004 0.022 -10000 0 -0.11 1 1
microtubule cytoskeleton organization 0 0.021 -10000 0 -10000 0 0
G2/M transition DNA damage checkpoint -0.002 0.002 -10000 0 -10000 0 0
PPP1R12A 0.016 0.001 -10000 0 -10000 0 0
interphase -0.002 0.002 -10000 0 -10000 0 0
PLK1/PRC1-2 -0.052 0.17 -10000 0 -0.47 31 31
GRASP65/GM130/RAB1/GTP/PLK1 -0.004 0.02 -10000 0 -10000 0 0
RAB1A 0.017 0 -10000 0 -10000 0 0
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA -0.01 0.054 -10000 0 -0.43 1 1
mitotic prometaphase -0.002 0.001 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.016 0.027 -10000 0 -10000 0 0
microtubule-based process -0.055 0.16 -10000 0 -0.47 27 27
Golgi organization -0.015 0.042 -10000 0 -0.13 10 10
Cohesin/SA2 -0.027 0.073 -10000 0 -0.41 7 7
PPP1CB/MYPT1 0 0.002 -10000 0 -10000 0 0
KIF20A -0.072 0.24 -10000 0 -0.72 27 27
APC/C/CDC20 -0.014 0.085 -10000 0 -0.47 6 6
PPP2R1A 0.017 0 -10000 0 -10000 0 0
chromosome segregation -0.049 0.12 -10000 0 -0.42 22 22
PRC1 -0.003 0.12 -10000 0 -0.72 6 6
ECT2 -0.28 0.23 -10000 0 -0.45 139 139
C13orf34 -0.008 0.048 -10000 0 -0.44 1 1
NUDC -0.003 0.025 -10000 0 -10000 0 0
regulation of attachment of spindle microtubules to kinetochore -0.096 0.15 -10000 0 -0.36 48 48
spindle assembly -0.008 0.032 -10000 0 -0.13 1 1
spindle stabilization -0.008 0.021 -10000 0 -0.078 2 2
APC/C/HCDH1 0.02 0.008 -10000 0 -10000 0 0
MKLP2/PLK1 -0.055 0.16 -10000 0 -0.47 27 27
CCNB1 -0.15 0.3 -10000 0 -0.73 48 48
PPP1CB 0.016 0.001 -10000 0 -10000 0 0
BTRC 0.017 0 -10000 0 -10000 0 0
ROCK2 0.006 0.028 -10000 0 -10000 0 0
TUBG1 0 0.021 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.26 0.25 -10000 0 -0.51 83 83
MLF1IP -0.041 0.17 -10000 0 -0.56 22 22
INCENP 0 0.085 -10000 0 -0.73 3 3
Regulation of nuclear SMAD2/3 signaling

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.031 0.017 -10000 0 -10000 0 0
HSPA8 0.008 0.009 -10000 0 -10000 0 0
SMAD3/SMAD4/ER alpha -0.004 0.12 -10000 0 -0.46 7 7
AKT1 -0.043 0.035 -10000 0 -10000 0 0
GSC -0.01 0.12 -10000 0 -0.58 7 7
NKX2-5 0.006 0.054 -10000 0 -0.72 1 1
muscle cell differentiation 0.068 0.13 0.48 5 -10000 0 5
SMAD2-3/SMAD4/SP1 -0.084 0.12 -10000 0 -0.52 2 2
SMAD4 -0.025 0.087 -10000 0 -0.62 3 3
CBFB 0.007 0.085 -10000 0 -0.72 3 3
SAP18 0.012 0.049 -10000 0 -0.72 1 1
Cbp/p300/MSG1 -0.008 0.17 -10000 0 -0.45 26 26
SMAD3/SMAD4/VDR 0 0.079 -10000 0 -10000 0 0
MYC -0.33 0.33 -10000 0 -0.6 133 133
CDKN2B -1.1 0.62 -10000 0 -1.4 177 177
AP1 -0.043 0.17 -10000 0 -0.7 7 7
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.01 0.054 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.26 0.19 -10000 0 -0.55 32 32
SP3 0.02 0.001 -10000 0 -10000 0 0
CREB1 0.017 0 -10000 0 -10000 0 0
FOXH1 0.011 0.026 -10000 0 -10000 0 0
SMAD3/SMAD4/GR -0.058 0.16 -10000 0 -0.45 25 25
GATA3 0.016 0.039 -10000 0 -10000 0 0
SKI/SIN3/HDAC complex/NCoR1 0.021 0.035 -10000 0 -10000 0 0
MEF2C/TIF2 -0.08 0.23 -10000 0 -0.6 35 35
endothelial cell migration 0.047 0.24 0.6 10 -10000 0 10
MAX 0.021 0.015 -10000 0 -10000 0 0
RBBP7 0.015 0.002 -10000 0 -10000 0 0
RBBP4 0.015 0.002 -10000 0 -10000 0 0
RUNX2 0.017 0 -10000 0 -10000 0 0
RUNX3 -0.025 0.16 -10000 0 -0.66 14 14
RUNX1 -0.2 0.34 -10000 0 -0.72 66 66
CTBP1 0.017 0 -10000 0 -10000 0 0
NR3C1 -0.049 0.2 -10000 0 -0.64 24 24
VDR 0 0.1 -10000 0 -0.63 6 6
CDKN1A -0.031 0.19 -10000 0 -1.5 3 3
KAT2B 0.004 0.007 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 -0.042 0.089 -10000 0 -0.37 3 3
DCP1A 0.017 0 -10000 0 -10000 0 0
SKI 0.015 0.002 -10000 0 -10000 0 0
SERPINE1 -0.055 0.24 -10000 0 -0.61 8 8
SMAD3/SMAD4/ATF2 -0.017 0.072 -10000 0 -0.53 1 1
SMAD3/SMAD4/ATF3 -0.026 0.1 -10000 0 -0.54 5 5
SAP30 0.015 0.002 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.068 0.062 -10000 0 -0.49 1 1
JUN -0.026 0.18 -10000 0 -0.74 6 6
SMAD3/SMAD4/IRF7 -0.013 0.07 -10000 0 -0.52 1 1
TFE3 0.021 0.011 -10000 0 -10000 0 0
COL1A2 -0.11 0.24 -10000 0 -0.6 44 44
mesenchymal cell differentiation 0.017 0.071 0.52 1 -10000 0 1
DLX1 0.01 0.07 -10000 0 -0.72 2 2
TCF3 0.014 0.049 -10000 0 -0.72 1 1
FOS -0.078 0.23 -10000 0 -0.64 33 33
SMAD3/SMAD4/Max -0.011 0.079 -10000 0 -0.53 1 1
Cbp/p300/SNIP1 0.006 0.017 -10000 0 -10000 0 0
ZBTB17 0.043 0.023 -10000 0 -10000 0 0
LAMC1 0.012 0.069 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 -0.13 0.22 -10000 0 -0.53 49 49
IRF7 0.022 0.001 -10000 0 -10000 0 0
ESR1 0.004 0.11 -10000 0 -0.64 6 6
HNF4A 0.017 0 -10000 0 -10000 0 0
MEF2C -0.078 0.25 -10000 0 -0.64 35 35
SMAD2-3/SMAD4 -0.06 0.094 -10000 0 -0.45 4 4
Cbp/p300/Src-1 0.046 0.053 -10000 0 -10000 0 0
IGHV3OR16-13 -0.034 0.046 -10000 0 -10000 0 0
TGIF2/HDAC complex -0.14 0.3 -10000 0 -0.72 49 49
CREBBP 0.027 0.013 -10000 0 -10000 0 0
SKIL 0 0.11 -10000 0 -0.72 5 5
HDAC1 0.015 0.002 -10000 0 -10000 0 0
HDAC2 0.015 0.002 -10000 0 -10000 0 0
SNIP1 0.009 0.008 -10000 0 -10000 0 0
GCN5L2 -0.17 0.33 -10000 0 -0.7 62 62
SMAD3/SMAD4/TFE3 -0.017 0.068 -10000 0 -0.52 1 1
MSG1/HSC70 -0.066 0.18 -10000 0 -0.54 28 28
SMAD2 -0.049 0.049 -10000 0 -10000 0 0
SMAD3 -0.015 0.075 -10000 0 -0.66 2 2
SMAD3/E2F4-5/DP1/p107/SMAD4 -0.15 0.19 -10000 0 -0.52 30 30
SMAD2/SMAD2/SMAD4 -0.015 0.049 -10000 0 -0.36 3 3
NCOR1 0.012 0.043 -10000 0 -0.63 1 1
NCOA2 0.017 0 -10000 0 -10000 0 0
NCOA1 0.011 0.061 -10000 0 -0.63 2 2
MYOD/E2A -0.01 0.071 -10000 0 -0.54 4 4
SMAD2-3/SMAD4/SP1/MIZ-1 -0.094 0.12 -10000 0 -0.62 1 1
IFNB1 0.003 0.067 -10000 0 -10000 0 0
SMAD3/SMAD4/MEF2C -0.096 0.24 -10000 0 -0.62 35 35
CITED1 -0.078 0.24 -10000 0 -0.72 28 28
SMAD2-3/SMAD4/ARC105 -0.041 0.082 -10000 0 -0.5 1 1
RBL1 -0.069 0.24 -10000 0 -0.72 26 26
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB -0.44 0.28 -10000 0 -0.59 167 167
RUNX1-3/PEBPB2 -0.16 0.23 -10000 0 -0.48 70 70
SMAD7 -0.062 0.17 -10000 0 -0.85 3 3
MYC/MIZ-1 -0.18 0.26 -10000 0 -0.55 21 21
SMAD3/SMAD4 0.042 0.19 0.36 3 -0.49 4 7
IL10 -0.007 0.091 -10000 0 -10000 0 0
PIASy/HDAC complex 0.007 0.011 -10000 0 -10000 0 0
PIAS3 0.018 0.051 -10000 0 -0.73 1 1
CDK2 -0.057 0.24 -10000 0 -0.72 25 25
IL5 -0.04 0.19 -10000 0 -0.64 18 18
CDK4 -0.03 0.2 -10000 0 -0.71 18 18
PIAS4 0.007 0.011 -10000 0 -10000 0 0
ATF3 0.004 0.098 -10000 0 -0.72 4 4
SMAD3/SMAD4/SP1 -0.052 0.097 -10000 0 -0.62 1 1
FOXG1 -0.076 0.24 -10000 0 -0.72 28 28
FOXO3 -0.051 0.048 -10000 0 -10000 0 0
FOXO1 -0.073 0.12 -10000 0 -0.56 10 10
FOXO4 -0.05 0.047 -10000 0 -10000 0 0
heart looping -0.077 0.24 -10000 0 -0.63 35 35
CEBPB -0.033 0.13 -10000 0 -0.78 6 6
SMAD3/SMAD4/DLX1 -0.021 0.087 -10000 0 -0.54 3 3
MYOD1 0.007 0.085 -10000 0 -0.72 3 3
SMAD3/SMAD4/HNF4 -0.017 0.072 -10000 0 -0.53 1 1
SMAD3/SMAD4/GATA3 -0.025 0.098 -10000 0 -0.51 1 1
SnoN/SIN3/HDAC complex/NCoR1 0 0.11 -10000 0 -0.72 5 5
SMAD3/SMAD4/RUNX1-3/PEBPB2 -0.15 0.22 -10000 0 -0.58 18 18
SMAD3/SMAD4/SP1-3 -0.036 0.079 -10000 0 -0.55 1 1
MED15 0.017 0 -10000 0 -10000 0 0
SP1 -0.015 0.055 -10000 0 -10000 0 0
SIN3B 0.015 0.002 -10000 0 -10000 0 0
SIN3A 0.015 0.002 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 -0.054 0.13 -10000 0 -0.44 1 1
ITGB5 -0.009 0.085 -10000 0 -10000 0 0
TGIF/SIN3/HDAC complex/CtBP 0.035 0.056 -10000 0 -10000 0 0
SMAD3/SMAD4/AR -0.019 0.081 -10000 0 -0.56 2 2
AR 0.014 0.049 -10000 0 -0.72 1 1
negative regulation of cell growth -0.13 0.17 -10000 0 -0.51 20 20
SMAD3/SMAD4/MYOD -0.023 0.091 -10000 0 -0.51 4 4
E2F5 -0.3 0.37 -10000 0 -0.72 96 96
E2F4 0.01 0.07 -10000 0 -0.72 2 2
SMAD2/SMAD2/SMAD4/FOXH1/SMIF -0.007 0.07 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4 -0.27 0.19 -10000 0 -0.5 30 30
TFDP1 -0.046 0.21 -10000 0 -0.72 19 19
SMAD3/SMAD4/AP1 -0.051 0.17 -10000 0 -0.75 6 6
SMAD3/SMAD4/RUNX2 -0.017 0.072 -10000 0 -0.53 1 1
TGIF2 -0.14 0.31 -10000 0 -0.72 49 49
TGIF1 -0.069 0.24 -10000 0 -0.72 26 26
ATF2 0.017 0 -10000 0 -10000 0 0
p75(NTR)-mediated signaling

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 -0.002 0.031 -9999 0 -0.46 1 1
Necdin/E2F1 -0.13 0.23 -9999 0 -0.51 57 57
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E -0.009 0.054 -9999 0 -0.39 1 1
NGF (dimer)/p75(NTR)/BEX1 -0.004 0.037 -9999 0 -0.4 2 2
NT-4/5 (dimer)/p75(NTR) 0 0 -9999 0 -10000 0 0
IKBKB 0.014 0.049 -9999 0 -0.72 1 1
AKT1 0.044 0 -9999 0 -10000 0 0
IKBKG 0.017 0 -9999 0 -10000 0 0
BDNF -0.036 0.19 -9999 0 -0.72 16 16
MGDIs/NGR/p75(NTR)/LINGO1 -0.028 0.12 -9999 0 -0.49 13 13
FURIN 0.017 0 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin -0.034 0.12 -9999 0 -0.45 17 17
LINGO1 0.004 0.098 -9999 0 -0.72 4 4
Sortilin/TRAF6/NRIF -0.012 0.054 -9999 0 -10000 0 0
proBDNF (dimer) -0.036 0.19 -9999 0 -0.72 16 16
NTRK1 0.017 0 -9999 0 -10000 0 0
RTN4R -0.016 0.15 -9999 0 -0.72 10 10
neuron apoptosis 0.028 0.1 -9999 0 -10000 0 0
IRAK1 0.01 0.07 -9999 0 -0.72 2 2
SHC1 0.026 0 -9999 0 -10000 0 0
ARHGDIA 0.017 0 -9999 0 -10000 0 0
RhoA/GTP 0 0 -9999 0 -10000 0 0
Gamma Secretase -0.013 0.064 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 -0.017 0.076 -9999 0 -10000 0 0
MAGEH1 -0.012 0.13 -9999 0 -0.63 10 10
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.075 0.15 -9999 0 -0.36 47 47
Mammalian IAPs/DIABLO -0.02 0.083 -9999 0 -0.42 3 3
proNGF (dimer) 0 0 -9999 0 -10000 0 0
MAGED1 0.014 0.049 -9999 0 -0.72 1 1
APP 0.017 0 -9999 0 -10000 0 0
NT-4/5 (dimer) 0 0 -9999 0 -10000 0 0
ZNF274 0.017 0 -9999 0 -10000 0 0
RhoA/GDP/RHOGDI 0 0 -9999 0 -10000 0 0
NGF 0 0 -9999 0 -10000 0 0
cell cycle arrest 0 0.028 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK -0.009 0.1 -9999 0 -10000 0 0
NT-4/5 (dimer)/p75(NTR)/TRAF6 0 0 -9999 0 -10000 0 0
NCSTN 0.017 0 -9999 0 -10000 0 0
mol:GTP -0.1 0.17 -9999 0 -0.39 60 60
PSENEN 0.017 0 -9999 0 -10000 0 0
mol:ceramide 0.033 0.025 -9999 0 -0.35 1 1
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.003 0.092 -9999 0 -0.39 2 2
p75(NTR)/beta APP 0 0 -9999 0 -10000 0 0
BEX1 0.011 0.061 -9999 0 -0.63 2 2
mol:GDP 0.012 0 -9999 0 -10000 0 0
NGF (dimer) -0.41 0.068 -9999 0 -0.42 218 218
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI -0.026 0.11 -9999 0 -0.44 13 13
PIK3R1 0.017 0 -9999 0 -10000 0 0
RAC1/GTP 0 0 -9999 0 -10000 0 0
MYD88 0.017 0 -9999 0 -10000 0 0
CHUK 0.017 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/PKA -0.11 0.18 -9999 0 -0.4 60 60
RHOB -0.029 0.18 -9999 0 -0.72 14 14
RHOA 0.017 0 -9999 0 -10000 0 0
MAGE-G1/E2F1 -0.036 0.14 -9999 0 -0.54 15 15
NT3 (dimer) 0.01 0.069 -9999 0 -0.72 2 2
TP53 0.015 0.13 -9999 0 -10000 0 0
PRDM4 0.033 0.026 -9999 0 -0.35 1 1
BDNF (dimer) -0.81 0.16 -9999 0 -0.81 224 224
PIK3CA 0.017 0 -9999 0 -10000 0 0
SORT1 0.014 0.043 -9999 0 -0.63 1 1
activation of caspase activity -0.009 0.053 -9999 0 -0.38 1 1
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.002 0.023 -9999 0 -0.35 1 1
RHOC 0.017 0 -9999 0 -10000 0 0
XIAP 0 0 -9999 0 -10000 0 0
MAPK10 0.055 0.089 -9999 0 -10000 0 0
DIABLO 0.017 0 -9999 0 -10000 0 0
SMPD2 0.033 0.026 -9999 0 -0.35 1 1
APH1B 0.014 0.049 -9999 0 -0.72 1 1
APH1A -0.007 0.12 -9999 0 -0.64 8 8
proNGF (dimer)/p75(NTR)/Sortilin -0.002 0.026 -9999 0 -0.4 1 1
PSEN1 0.017 0 -9999 0 -10000 0 0
APAF-1/Pro-Caspase 9 -0.005 0.051 -9999 0 -0.54 2 2
NT3 (dimer)/p75(NTR) -0.005 0.051 -9999 0 -0.54 2 2
MAPK8 0.059 0.08 -9999 0 -10000 0 0
MAPK9 0.059 0.08 -9999 0 -10000 0 0
APAF1 0.01 0.07 -9999 0 -0.72 2 2
NTF3 0.01 0.07 -9999 0 -0.72 2 2
NTF4 0 0 -9999 0 -10000 0 0
NDN -0.12 0.26 -9999 0 -0.63 47 47
RAC1/GDP 0 0 -9999 0 -10000 0 0
RhoA-B-C/GDP -0.1 0.16 -9999 0 -0.67 4 4
p75 CTF/Sortilin/TRAF6/NRIF -0.002 0.023 -9999 0 -10000 0 0
RhoA-B-C/GTP -0.1 0.17 -9999 0 -0.39 60 60
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.028 0.099 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.031 0.11 -9999 0 -0.41 16 16
PRKACB -0.16 0.29 -9999 0 -0.63 60 60
proBDNF (dimer)/p75 ECD -0.038 0.14 -9999 0 -0.54 16 16
ChemicalAbstracts:86-01-1 0 0 -9999 0 -10000 0 0
BIRC3 -0.019 0.15 -9999 0 -0.66 12 12
BIRC2 0.017 0 -9999 0 -10000 0 0
neuron projection morphogenesis -0.11 0.17 -9999 0 -0.52 23 23
BAD 0.067 0.081 -9999 0 -10000 0 0
RIPK2 -0.12 0.29 -9999 0 -0.72 43 43
NGFR 0.017 0 -9999 0 -10000 0 0
CYCS 0.038 0.044 -9999 0 -10000 0 0
ADAM17 0.017 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/TRAF6/RIP2 -0.08 0.16 -9999 0 -0.42 43 43
BCL2L11 0.067 0.081 -9999 0 -10000 0 0
BDNF (dimer)/p75(NTR) -0.038 0.14 -9999 0 -0.54 16 16
PI3K 0 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 -0.003 0.036 -9999 0 -0.42 1 1
NDNL2 0.014 0.049 -9999 0 -0.72 1 1
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
PRKCI -0.003 0.12 -9999 0 -0.72 6 6
NGF (dimer)/p75(NTR) 0 0 -9999 0 -10000 0 0
ChemicalAbstracts:146-91-8 0 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE -0.003 0.036 -9999 0 -0.42 1 1
TRAF6 0.017 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
PRKCZ 0 0 -9999 0 -10000 0 0
PLG 0.017 0 -9999 0 -10000 0 0
oligodendrocyte cell fate commitment 0 0 -9999 0 -10000 0 0
CASP6 0.014 0.098 -9999 0 -10000 0 0
SQSTM1 0.017 0 -9999 0 -10000 0 0
NGFRAP1 0.005 0.086 -9999 0 -0.63 4 4
CASP3 0.066 0.077 -9999 0 -10000 0 0
E2F1 -0.029 0.18 -9999 0 -0.72 14 14
CASP9 0.017 0 -9999 0 -10000 0 0
IKK complex -0.022 0.052 -9999 0 -0.46 1 1
NGF (dimer)/TRKA 0 0 -9999 0 -10000 0 0
MMP7 -0.7 0.12 -9999 0 -0.72 218 218
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.001 0.021 -9999 0 -10000 0 0
MMP3 -0.68 0.18 -9999 0 -0.72 210 210
APAF-1/Caspase 9 -0.018 0.063 -9999 0 -10000 0 0
FOXA2 and FOXA3 transcription factor networks

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.068 0.3 -9999 0 -1 9 9
PCK1 -0.73 0.7 -9999 0 -1.3 133 133
HNF4A -0.082 0.31 -9999 0 -1.2 6 6
KCNJ11 -0.057 0.32 -9999 0 -1.1 7 7
AKT1 0.013 0.11 -9999 0 -10000 0 0
response to starvation -0.008 0.022 -9999 0 -10000 0 0
DLK1 -0.057 0.32 -9999 0 -1.1 7 7
NKX2-1 0.034 0.25 -9999 0 -0.8 5 5
ACADM -0.074 0.32 -9999 0 -1.1 10 10
TAT -0.082 0.24 -9999 0 -0.79 10 10
CEBPB -0.014 0.12 -9999 0 -0.72 6 6
CEBPA 0.011 0.013 -9999 0 -10000 0 0
TTR -0.8 0.66 -9999 0 -1.3 131 131
PKLR -0.079 0.31 -9999 0 -1.1 8 8
APOA1 -0.078 0.36 -9999 0 -1.2 10 10
CPT1C -0.073 0.31 -9999 0 -0.97 11 11
ALAS1 -0.005 0.16 -9999 0 -10000 0 0
TFRC -0.072 0.29 -9999 0 -0.98 8 8
FOXF1 -0.008 0.12 -9999 0 -0.64 7 7
NF1 0.027 0.001 -9999 0 -10000 0 0
HNF1A (dimer) 0.02 0.056 -9999 0 -10000 0 0
CPT1A -0.069 0.31 -9999 0 -0.98 12 12
HMGCS1 -0.075 0.31 -9999 0 -0.96 11 11
NR3C1 -0.044 0.2 -9999 0 -0.62 24 24
CPT1B -0.066 0.3 -9999 0 -1 8 8
chromatin remodeling 0 0 -9999 0 -10000 0 0
SP1 0.022 0.027 -9999 0 -10000 0 0
GCK -0.066 0.3 -9999 0 -1 8 8
CREB1 -0.095 0.11 -9999 0 -10000 0 0
IGFBP1 -0.087 0.25 -9999 0 -0.75 15 15
PDX1 -0.017 0.2 -9999 0 -0.92 2 2
UCP2 -0.066 0.3 -9999 0 -1 8 8
ALDOB -0.12 0.42 -9999 0 -1.1 23 23
AFP -0.12 0.16 -9999 0 -0.82 1 1
BDH1 -0.067 0.31 -9999 0 -1.1 8 8
HADH -0.057 0.32 -9999 0 -1.1 7 7
F2 -0.063 0.32 -9999 0 -1.2 6 6
HNF1A 0.02 0.056 -9999 0 -10000 0 0
G6PC -0.076 0.13 -9999 0 -10000 0 0
SLC2A2 -0.061 0.25 -9999 0 -0.77 5 5
INS 0.012 0.038 -9999 0 -10000 0 0
FOXA1 -0.16 0.29 -9999 0 -0.62 62 62
FOXA3 -0.092 0.16 -9999 0 -0.66 7 7
FOXA2 -0.073 0.38 -9999 0 -1.1 11 11
ABCC8 -0.11 0.41 -9999 0 -1.1 21 21
ALB -0.12 0.17 -9999 0 -0.66 4 4
IL2 signaling events mediated by PI3K

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.032 0.062 -10000 0 -0.53 1 1
UGCG -0.021 0.025 -10000 0 -10000 0 0
AKT1/mTOR/p70S6K/Hsp90/TERT -0.2 0.17 -10000 0 -0.47 4 4
mol:GTP -0.001 0.001 -10000 0 -10000 0 0
mol:glucosylceramide -0.015 0.034 -10000 0 -10000 0 0
mol:DAG 0.043 0.083 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.31 0.2 -10000 0 -0.52 92 92
FRAP1 -0.35 0.27 -10000 0 -0.62 92 92
FOXO3 -0.21 0.19 -10000 0 -0.56 3 3
AKT1 -0.24 0.2 -10000 0 -0.45 88 88
GAB2 0.003 0.007 -10000 0 -10000 0 0
SMPD1 -0.19 0.33 -10000 0 -0.82 47 47
SGMS1 -0.021 0.025 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP 0.005 0.012 -10000 0 -10000 0 0
CALM1 0.017 0 -10000 0 -10000 0 0
cell proliferation -0.074 0.11 -10000 0 -10000 0 0
EIF3A 0.017 0 -10000 0 -10000 0 0
PI3K 0.005 0.012 -10000 0 -10000 0 0
RPS6KB1 -0.011 0.038 -10000 0 -10000 0 0
mol:sphingomyelin 0.043 0.083 -10000 0 -10000 0 0
natural killer cell activation -0.009 0.005 -10000 0 -0.014 85 85
JAK3 0.004 0.008 -10000 0 -10000 0 0
PIK3R1 0.003 0.008 -10000 0 -10000 0 0
JAK1 0.003 0.008 -10000 0 -10000 0 0
NFKB1 0.017 0 -10000 0 -10000 0 0
MYC -0.35 0.28 -10000 0 -0.63 92 92
MYB 0.007 0.14 -10000 0 -1.3 2 2
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.085 0.12 -10000 0 -0.42 1 1
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.002 0.07 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.084 0.12 -10000 0 -0.41 1 1
Rac1/GDP 0.006 0.014 -10000 0 -10000 0 0
T cell proliferation -0.089 0.1 -10000 0 -0.39 1 1
SHC1 0.003 0.007 -10000 0 -10000 0 0
RAC1 0.016 0.001 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity 0.007 0.007 -10000 0 -0.066 2 2
PRKCZ -0.092 0.11 -10000 0 -0.4 1 1
NF kappa B1 p50/RelA -0.31 0.2 -10000 0 -0.52 90 90
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K 0.006 0.049 -10000 0 -10000 0 0
HSP90AA1 0.014 0.049 -10000 0 -0.72 1 1
RELA 0.017 0 -10000 0 -10000 0 0
IL2RA -0.02 0.13 -10000 0 -0.73 7 7
IL2RB 0.001 0.043 -10000 0 -0.64 1 1
TERT 0.017 0 -10000 0 -10000 0 0
E2F1 0.005 0.071 -10000 0 -0.46 2 2
SOS1 0.003 0.007 -10000 0 -10000 0 0
RPS6 0 0.11 -10000 0 -0.72 5 5
mol:cAMP -0.004 0.003 0.031 2 -10000 0 2
PTPN11 -0.001 0.05 -10000 0 -0.73 1 1
IL2RG -0.005 0.074 -10000 0 -0.64 3 3
actin cytoskeleton organization -0.089 0.1 -10000 0 -0.39 1 1
GRB2 0.003 0.007 -10000 0 -10000 0 0
IL2 0.003 0.008 -10000 0 -10000 0 0
PIK3CA 0.003 0.008 -10000 0 -10000 0 0
Rac1/GTP 0.007 0.018 -10000 0 -10000 0 0
LCK -0.003 0.065 -10000 0 -0.68 2 2
BCL2 -0.61 0.44 -10000 0 -0.93 147 147
IGF1 pathway

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.017 0 -9999 0 -10000 0 0
PTK2 0.014 0.049 -9999 0 -0.72 1 1
CRKL -0.16 0.18 -9999 0 -0.68 4 4
GRB2/SOS1/SHC 0 0 -9999 0 -10000 0 0
HRAS 0.017 0 -9999 0 -10000 0 0
IRS1/Crk -0.16 0.19 -9999 0 -0.68 5 5
IGF-1R heterotetramer/IGF1/PTP1B -0.2 0.18 -9999 0 -0.47 4 4
AKT1 -0.11 0.16 -9999 0 -0.56 4 4
BAD -0.096 0.15 -9999 0 -0.52 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
CRK -0.16 0.19 -9999 0 -0.68 5 5
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.18 0.17 -9999 0 -0.69 5 5
RAF1 -0.086 0.15 -9999 0 -0.48 4 4
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.17 0.15 -9999 0 -0.65 4 4
YWHAZ 0.017 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.2 0.18 -9999 0 -0.36 126 126
PIK3CA 0.017 0 -9999 0 -10000 0 0
RPS6KB1 -0.11 0.16 -9999 0 -0.58 5 5
GNB2L1 0.017 0 -9999 0 -10000 0 0
positive regulation of MAPKKK cascade -0.078 0.13 -9999 0 -0.41 4 4
PXN 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
cell adhesion 0 0 -9999 0 -10000 0 0
GRB2/SOS1 0 0 -9999 0 -10000 0 0
HRAS/GTP -0.14 0.13 -9999 0 -0.58 4 4
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.15 0.13 -9999 0 -10000 0 0
IGF-1R heterotetramer -0.026 0.039 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS/Nck -0.18 0.17 -9999 0 -0.69 4 4
Crk/p130 Cas/Paxillin -0.16 0.15 -9999 0 -0.61 5 5
IGF1R -0.026 0.039 -9999 0 -10000 0 0
IGF1 -0.35 0.33 -9999 0 -0.64 126 126
IRS2/Crk -0.15 0.18 -9999 0 -0.65 6 6
PI3K -0.16 0.15 -9999 0 -0.65 4 4
apoptosis 0.076 0.14 -9999 0 -10000 0 0
HRAS/GDP 0 0 -9999 0 -10000 0 0
PRKCD -0.19 0.22 -9999 0 -0.58 4 4
RAF1/14-3-3 E -0.068 0.13 -9999 0 -10000 0 0
BAD/14-3-3 -0.08 0.14 -9999 0 -0.47 4 4
PRKCZ -0.12 0.16 -9999 0 -0.57 4 4
Crk/p130 Cas/Paxillin/FAK1 -0.11 0.11 -9999 0 -0.5 2 2
PTPN1 0.017 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.22 0.24 -9999 0 -0.42 126 126
BCAR1 0.017 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.2 0.19 -9999 0 -0.58 18 18
mol:GDP 0 0 -9999 0 -10000 0 0
SOS1 0.017 0 -9999 0 -10000 0 0
IRS1/NCK2 -0.16 0.18 -9999 0 -0.68 4 4
GRB10 -0.029 0.18 -9999 0 -0.72 14 14
PTPN11 -0.16 0.19 -9999 0 -0.69 5 5
IRS1 -0.19 0.2 -9999 0 -0.36 126 126
IRS2 -0.16 0.19 -9999 0 -0.69 5 5
IGF-1R heterotetramer/IGF1 -0.27 0.24 -9999 0 -0.48 126 126
GRB2 0.017 0 -9999 0 -10000 0 0
PDPK1 -0.13 0.17 -9999 0 -0.61 4 4
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
PRKD1 -0.2 0.23 -9999 0 -0.64 7 7
SHC1 0.017 0 -9999 0 -10000 0 0
Noncanonical Wnt signaling pathway

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 0.017 0 -9999 0 -10000 0 0
GNB1/GNG2 -0.12 0.13 -9999 0 -0.51 6 6
mol:DAG -0.098 0.18 -9999 0 -0.55 12 12
PLCG1 -0.1 0.18 -9999 0 -0.57 12 12
YES1 -0.1 0.17 -9999 0 -0.43 25 25
FZD3 -0.14 0.3 -9999 0 -0.72 48 48
FZD6 -0.029 0.18 -9999 0 -0.72 14 14
G protein -0.11 0.12 -9999 0 -0.55 3 3
MAP3K7 -0.064 0.15 -9999 0 -0.51 3 3
mol:Ca2+ -0.095 0.17 -9999 0 -0.53 12 12
mol:IP3 -0.098 0.18 -9999 0 -0.55 12 12
NLK 0.004 0.007 -9999 0 -10000 0 0
GNB1 0.017 0 -9999 0 -10000 0 0
CAMK2A -0.08 0.16 -9999 0 -0.49 12 12
MAP3K7IP1 0.017 0 -9999 0 -10000 0 0
Noncanonical Wnts/FZD -0.12 0.18 -9999 0 -0.47 25 25
CSNK1A1 0.017 0 -9999 0 -10000 0 0
GNAS -0.1 0.17 -9999 0 -0.43 25 25
GO:0007205 -0.094 0.17 -9999 0 -0.52 12 12
WNT6 0.014 0.049 -9999 0 -0.72 1 1
WNT4 -0.01 0.13 -9999 0 -0.65 9 9
NFAT1/CK1 alpha -0.1 0.12 -9999 0 -0.53 3 3
GNG2 0.017 0 -9999 0 -10000 0 0
WNT5A -0.092 0.26 -9999 0 -0.72 33 33
WNT11 -0.14 0.3 -9999 0 -0.72 46 46
CDC42 -0.088 0.16 -9999 0 -0.5 6 6
amb2 Integrin signaling

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.023 0.086 -9999 0 -0.45 8 8
alphaM/beta2 Integrin/GPIbA -0.019 0.073 -9999 0 -0.57 2 2
alphaM/beta2 Integrin/proMMP-9 -0.033 0.11 -9999 0 -0.46 13 13
PLAUR 0.014 0.049 -9999 0 -0.72 1 1
HMGB1 0 0.054 -9999 0 -0.74 1 1
alphaM/beta2 Integrin/Talin -0.019 0.073 -9999 0 -0.44 6 6
AGER 0.003 0.02 -9999 0 -10000 0 0
RAP1A 0.017 0 -9999 0 -10000 0 0
SELPLG 0.008 0.075 -9999 0 -0.63 3 3
mol:LDL 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.071 0.099 -9999 0 -0.8 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
MMP9 -0.006 0.13 -9999 0 -0.71 7 7
CYR61 -0.042 0.2 -9999 0 -0.72 18 18
TLN1 0.017 0 -9999 0 -10000 0 0
Rap1/GTP -0.033 0.074 -9999 0 -0.47 2 2
RHOA 0.017 0 -9999 0 -10000 0 0
P-selectin oligomer -0.067 0.22 -9999 0 -0.63 29 29
MYH2 0.003 0.14 -9999 0 -0.55 3 3
MST1R 0.017 0 -9999 0 -10000 0 0
leukocyte activation during inflammatory response -0.008 0.063 -9999 0 -0.64 1 1
APOB 0.017 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
complement component iC3b receptor activity 0 0 -9999 0 -10000 0 0
MMP2 0.01 0.07 -9999 0 -0.72 2 2
JAM3 0.017 0 -9999 0 -10000 0 0
GP1BA 0.017 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/CTGF -0.023 0.086 -9999 0 -0.45 8 8
alphaM/beta2 Integrin -0.001 0.12 -9999 0 -0.4 8 8
JAM3 homodimer 0.017 0 -9999 0 -10000 0 0
ICAM2 0.005 0.089 -9999 0 -0.66 4 4
ICAM1 -0.023 0.17 -9999 0 -0.72 12 12
phagocytosis triggered by activation of immune response cell surface activating receptor -0.001 0.11 -9999 0 -0.39 8 8
cell adhesion -0.019 0.073 -9999 0 -0.57 2 2
NFKB1 -0.071 0.18 -9999 0 -0.8 2 2
THY1 -0.075 0.24 -9999 0 -0.72 28 28
RhoA/GDP 0 0 -9999 0 -10000 0 0
Lipoprotein(a) 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/LRP/tPA -0.012 0.076 -9999 0 -0.56 2 2
IL6 -0.21 0.32 -9999 0 -0.55 105 105
ITGB2 -0.011 0.095 -9999 0 -0.63 5 5
elevation of cytosolic calcium ion concentration -0.14 0.21 -9999 0 -0.46 53 53
alphaM/beta2 Integrin/JAM2/JAM3 -0.22 0.2 -9999 0 -0.74 6 6
JAM2 -0.36 0.32 -9999 0 -0.63 131 131
alphaM/beta2 Integrin/ICAM1 -0.044 0.15 -9999 0 -0.48 17 17
alphaM/beta2 Integrin/uPA/Plg -0.14 0.2 -9999 0 -0.46 53 53
RhoA/GTP 0.002 0.12 -9999 0 -0.42 4 4
positive regulation of phagocytosis -0.054 0.12 -9999 0 -0.68 5 5
Ron/MSP -0.024 0.11 -9999 0 -0.54 10 10
alphaM/beta2 Integrin/uPAR/uPA -0.14 0.21 -9999 0 -0.46 53 53
alphaM/beta2 Integrin/uPAR -0.021 0.08 -9999 0 -0.45 7 7
PLAU -0.19 0.33 -9999 0 -0.72 64 64
PLAT 0.011 0.065 -9999 0 -0.68 2 2
actin filament polymerization 0.004 0.13 -9999 0 -0.52 3 3
MST1 -0.016 0.15 -9999 0 -0.72 10 10
alphaM/beta2 Integrin/lipoprotein(a) -0.008 0.064 -9999 0 -0.65 1 1
TNF -0.053 0.17 -9999 0 -0.7 2 2
RAP1B 0.017 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/uPA -0.16 0.22 -9999 0 -0.49 66 66
fibrinolysis -0.14 0.2 -9999 0 -0.45 53 53
HCK -0.044 0.19 -9999 0 -0.63 21 21
dendritic cell antigen processing and presentation -0.001 0.11 -9999 0 -0.39 8 8
VTN 0.017 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/CYR61 -0.058 0.15 -9999 0 -0.48 24 24
LPA 0.017 0 -9999 0 -10000 0 0
LRP1 0.017 0 -9999 0 -10000 0 0
cell migration -0.026 0.12 -9999 0 -0.59 7 7
FN1 -0.069 0.24 -9999 0 -0.72 26 26
alphaM/beta2 Integrin/Thy1 -0.078 0.17 -9999 0 -0.48 34 34
MPO -0.029 0.18 -9999 0 -0.72 14 14
KNG1 -0.004 0.12 -9999 0 -0.64 7 7
RAP1/GDP 0 0 -9999 0 -10000 0 0
ROCK1 0.013 0.12 -9999 0 -0.42 2 2
ELA2 0.017 0 -9999 0 -10000 0 0
PLG 0.017 0 -9999 0 -10000 0 0
CTGF 0.01 0.07 -9999 0 -0.72 2 2
alphaM/beta2 Integrin/Hck -0.054 0.15 -9999 0 -0.48 22 22
ITGAM -0.003 0.062 -9999 0 -0.62 2 2
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.058 0.16 -9999 0 -0.75 5 5
HP 0.017 0 -9999 0 -10000 0 0
leukocyte adhesion -0.25 0.19 -9999 0 -0.54 30 30
SELP -0.067 0.22 -9999 0 -0.63 29 29
S1P1 pathway

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.068 0.18 -9999 0 -0.56 21 21
PDGFRB 0.013 0.007 -9999 0 -10000 0 0
SPHK1 -0.047 0.087 -9999 0 -10000 0 0
mol:S1P -0.086 0.14 -9999 0 -0.45 17 17
S1P1/S1P/Gi -0.086 0.2 -9999 0 -0.54 16 16
GNAO1 0.012 0.008 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/PLCgamma1 -0.091 0.2 -9999 0 -0.58 12 12
PLCG1 -0.096 0.21 -9999 0 -0.54 20 20
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB 0.013 0.007 -9999 0 -10000 0 0
GNAI2 0.012 0.008 -9999 0 -10000 0 0
GNAI3 0.012 0.009 -9999 0 -10000 0 0
GNAI1 -0.075 0.22 -9999 0 -0.64 30 30
mol:GDP 0 0 -9999 0 -10000 0 0
EDG1 -0.051 0.23 -9999 0 -0.58 32 32
S1P1/S1P -0.13 0.22 -9999 0 -0.68 21 21
negative regulation of cAMP metabolic process -0.084 0.19 -9999 0 -0.52 16 16
MAPK3 -0.1 0.22 -9999 0 -0.53 21 21
calcium-dependent phospholipase C activity -0.003 0.003 -9999 0 -10000 0 0
Rac1/GDP 0 0 -9999 0 -10000 0 0
RhoA/GDP 0 0 -9999 0 -10000 0 0
KDR 0.012 0.043 -9999 0 -10000 0 0
PLCB2 -0.077 0.21 -9999 0 -0.58 21 21
RAC1 0.017 0 -9999 0 -10000 0 0
RhoA/GTP -0.11 0.18 -9999 0 -0.54 21 21
receptor internalization -0.12 0.2 -9999 0 -0.62 21 21
PTGS2 -0.14 0.28 -9999 0 -0.58 36 36
Rac1/GTP -0.11 0.18 -9999 0 -0.54 21 21
RHOA 0.017 0 -9999 0 -10000 0 0
VEGFA -0.058 0.22 -9999 0 -0.73 21 21
negative regulation of T cell proliferation -0.084 0.19 -9999 0 -0.52 16 16
GO:0007205 0 0 -9999 0 -10000 0 0
GNAZ 0.012 0.009 -9999 0 -10000 0 0
MAPK1 -0.1 0.22 -9999 0 -0.5 25 25
S1P1/S1P/PDGFB-D/PDGFRB -0.099 0.25 -9999 0 -0.7 21 21
ABCC1 -0.06 0.22 -9999 0 -0.72 23 23
EPHB forward signaling

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 -0.014 0.078 -10000 0 -0.45 7 7
cell-cell adhesion 0.17 0.2 0.63 21 -10000 0 21
Ephrin B/EPHB2/RasGAP -0.016 0.075 -10000 0 -10000 0 0
ITSN1 0.017 0 -10000 0 -10000 0 0
PIK3CA 0.017 0 -10000 0 -10000 0 0
SHC1 0.017 0 -10000 0 -10000 0 0
Ephrin B1/EPHB3 -0.051 0.14 -10000 0 -0.46 25 25
Ephrin B1/EPHB1 -0.17 0.22 -10000 0 -0.47 82 82
HRAS/GDP -0.16 0.2 -10000 0 -0.61 21 21
Ephrin B/EPHB1/GRB7 -0.16 0.2 -10000 0 -0.78 5 5
Endophilin/SYNJ1 0.038 0.072 -10000 0 -10000 0 0
KRAS 0.017 0 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src -0.14 0.19 -10000 0 -0.78 1 1
endothelial cell migration -0.071 0.15 -10000 0 -0.76 1 1
GRB2 0.017 0 -10000 0 -10000 0 0
GRB7 -0.009 0.14 -10000 0 -0.72 8 8
PAK1 0.048 0.073 -10000 0 -10000 0 0
HRAS 0.017 0 -10000 0 -10000 0 0
RRAS 0.038 0.073 -10000 0 -10000 0 0
DNM1 0.01 0.07 -10000 0 -0.72 2 2
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.1 0.2 -10000 0 -0.68 2 2
lamellipodium assembly -0.17 0.2 -10000 0 -0.63 21 21
Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.041 0.13 -10000 0 -0.42 1 1
PIK3R1 0.017 0 -10000 0 -10000 0 0
EPHB2 -0.002 0.12 -10000 0 -0.71 6 6
EPHB3 -0.064 0.23 -10000 0 -0.71 25 25
EPHB1 -0.25 0.36 -10000 0 -0.72 82 82
EPHB4 -0.12 0.28 -10000 0 -0.72 40 40
mol:GDP -0.14 0.2 -10000 0 -0.59 19 19
Ephrin B/EPHB2 -0.013 0.069 -10000 0 -0.39 6 6
Ephrin B/EPHB3 -0.045 0.12 -10000 0 -0.39 23 23
JNK cascade -0.12 0.23 -10000 0 -0.75 7 7
Ephrin B/EPHB1 -0.14 0.19 -10000 0 -0.39 82 82
RAP1/GDP -0.11 0.18 -10000 0 -0.51 18 18
EFNB2 0.011 0.065 -10000 0 -0.68 2 2
EFNB3 0.017 0 -10000 0 -10000 0 0
EFNB1 0.017 0 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 -0.17 0.22 -10000 0 -0.44 83 83
RAP1B 0.017 0 -10000 0 -10000 0 0
RAP1A 0.017 0 -10000 0 -10000 0 0
CDC42/GTP -0.12 0.16 -10000 0 -0.6 6 6
Rap1/GTP -0.12 0.16 -10000 0 -0.6 6 6
axon guidance -0.014 0.078 -10000 0 -0.44 7 7
MAPK3 -0.019 0.12 -10000 0 -10000 0 0
MAPK1 -0.017 0.12 -10000 0 -0.5 1 1
Rac1/GDP -0.091 0.21 -10000 0 -0.54 18 18
actin cytoskeleton reorganization -0.13 0.16 -10000 0 -0.48 23 23
CDC42/GDP -0.091 0.21 -10000 0 -0.54 18 18
PI3K -0.072 0.15 -10000 0 -0.78 1 1
EFNA5 0.014 0.043 -10000 0 -0.63 1 1
Ephrin B2/EPHB4 -0.087 0.19 -10000 0 -0.48 41 41
Ephrin B/EPHB2/Intersectin/N-WASP 0.04 0.054 -10000 0 -10000 0 0
CDC42 0.017 0 -10000 0 -10000 0 0
RAS family/GTP -0.12 0.16 -10000 0 -0.6 7 7
PTK2 0.035 0.07 -10000 0 -0.71 1 1
MAP4K4 -0.12 0.23 -10000 0 -0.76 7 7
SRC 0.017 0 -10000 0 -10000 0 0
KALRN 0.017 0 -10000 0 -10000 0 0
Intersectin/N-WASP -0.002 0.031 -10000 0 -0.46 1 1
neuron projection morphogenesis -0.067 0.19 -10000 0 -0.57 2 2
MAP2K1 -0.028 0.12 -10000 0 -0.38 1 1
WASL 0.014 0.043 -10000 0 -0.63 1 1
Ephrin B1/EPHB1-2/NCK1 -0.16 0.21 -10000 0 -0.43 83 83
cell migration -0.019 0.13 -10000 0 -0.4 1 1
NRAS 0.007 0.085 -10000 0 -0.72 3 3
SYNJ1 0.038 0.073 -10000 0 -10000 0 0
PXN 0.017 0 -10000 0 -10000 0 0
TF 0.048 0.07 -10000 0 -10000 0 0
HRAS/GTP -0.13 0.17 -10000 0 -0.66 5 5
Ephrin B1/EPHB1-2 -0.16 0.22 -10000 0 -0.44 84 84
cell adhesion mediated by integrin -0.012 0.075 0.35 1 -10000 0 1
RAC1 0.017 0 -10000 0 -10000 0 0
mol:GTP -0.14 0.18 -10000 0 -0.72 5 5
RAC1-CDC42/GTP -0.15 0.18 -10000 0 -0.62 13 13
RASA1 0.01 0.07 -10000 0 -0.72 2 2
RAC1-CDC42/GDP -0.11 0.18 -10000 0 -0.51 18 18
ruffle organization -0.13 0.24 -10000 0 -0.64 22 22
NCK1 0.017 0 -10000 0 -10000 0 0
receptor internalization 0.044 0.079 -10000 0 -10000 0 0
Ephrin B/EPHB2/KALRN -0.013 0.067 -10000 0 -10000 0 0
ROCK1 -0.015 0.14 -10000 0 -0.42 22 22
RAS family/GDP -0.12 0.14 -10000 0 -0.45 20 20
Rac1/GTP -0.18 0.22 -10000 0 -0.69 21 21
Ephrin B/EPHB1/Src/Paxillin -0.046 0.13 -10000 0 -0.42 1 1
Thromboxane A2 receptor signaling

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.062 0.22 -10000 0 -0.72 23 23
GNB1/GNG2 -0.093 0.063 -10000 0 -0.21 11 11
AKT1 -0.052 0.088 -10000 0 -10000 0 0
EGF -0.18 0.31 -10000 0 -0.67 65 65
mol:TXA2 -0.001 0 -10000 0 -10000 0 0
FGR -0.12 0.095 -10000 0 -10000 0 0
mol:Ca2+ -0.092 0.12 -10000 0 -0.32 13 13
LYN -0.12 0.095 -10000 0 -10000 0 0
RhoA/GTP -0.041 0.039 -10000 0 -10000 0 0
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.097 0.14 -10000 0 -0.37 6 6
GNG2 0.017 0 -10000 0 -10000 0 0
ARRB2 0.017 0 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.034 0.11 -10000 0 -0.56 6 6
G beta5/gamma2 -0.12 0.087 -10000 0 -0.28 14 14
PRKCH -0.099 0.14 -10000 0 -0.41 10 10
DNM1 0.01 0.07 -10000 0 -0.72 2 2
TXA2/TP beta/beta Arrestin3 -0.031 0.027 -10000 0 -0.26 1 1
mol:GTP -0.001 0.001 -10000 0 -10000 0 0
PTGDR -0.49 0.27 -10000 0 -0.63 176 176
G12 family/GTP -0.11 0.096 -10000 0 -0.31 11 11
ADRBK1 0.017 0 -10000 0 -10000 0 0
ADRBK2 0.017 0 -10000 0 -10000 0 0
RhoA/GTP/ROCK1 0 0 -10000 0 -10000 0 0
mol:GDP 0.12 0.1 0.29 26 -10000 0 26
mol:NADP 0.013 0.049 -10000 0 -0.72 1 1
RAB11A 0.017 0 -10000 0 -10000 0 0
PRKG1 0.017 0 -10000 0 -10000 0 0
mol:IP3 -0.12 0.15 -10000 0 -0.39 16 16
cell morphogenesis 0 0 -10000 0 -10000 0 0
PLCB2 -0.15 0.19 -10000 0 -0.53 16 16
mol:cGMP 0 0 -10000 0 -10000 0 0
BLK -0.2 0.17 -10000 0 -0.45 57 57
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK -0.14 0.13 -10000 0 -0.45 19 19
RHOA 0.017 0 -10000 0 -10000 0 0
PTGIR 0.017 0 -10000 0 -10000 0 0
PRKCB1 -0.17 0.18 -10000 0 -0.45 35 35
GNAQ 0 0 -10000 0 -10000 0 0
mol:L-citrulline 0.013 0.049 -10000 0 -0.72 1 1
TXA2/TXA2-R family -0.15 0.2 -10000 0 -0.54 15 15
LCK -0.12 0.1 -10000 0 -0.48 2 2
TXA2/TP beta/beta Arrestin3/RAB11/GDP -0.17 0.09 -10000 0 -10000 0 0
TXA2-R family/G12 family/GDP/G beta/gamma -0.027 0.038 -10000 0 -10000 0 0
TXA2/TP beta/beta Arrestin2/RAB11/GDP -0.17 0.09 -10000 0 -10000 0 0
MAPK14 -0.058 0.099 -10000 0 -10000 0 0
TGM2/GTP -0.14 0.18 -10000 0 -0.48 14 14
MAPK11 -0.059 0.1 -10000 0 -0.41 1 1
ARHGEF1 -0.045 0.077 -10000 0 -10000 0 0
GNAI2 0.017 0 -10000 0 -10000 0 0
JNK cascade -0.12 0.15 -10000 0 -0.4 13 13
RAB11/GDP 0.018 0.001 -10000 0 -10000 0 0
ICAM1 -0.083 0.13 -10000 0 -0.35 15 15
cAMP biosynthetic process -0.12 0.14 -10000 0 -0.38 14 14
Gq family/GTP/EBP50 0.004 0.085 -10000 0 -0.28 10 10
actin cytoskeleton reorganization 0 0 -10000 0 -10000 0 0
SRC -0.12 0.095 -10000 0 -10000 0 0
GNB5 0.007 0.085 -10000 0 -0.72 3 3
GNB1 0.017 0 -10000 0 -10000 0 0
EGF/EGFR -0.13 0.11 -10000 0 -0.37 8 8
VCAM1 -0.077 0.12 -10000 0 -0.43 5 5
TP beta/Gq family/GDP/G beta5/gamma2 -0.034 0.11 -10000 0 -0.56 6 6
platelet activation -0.08 0.13 -10000 0 -0.34 4 4
PGI2/IP 0 0 -10000 0 -10000 0 0
PRKACA -0.22 0.13 -10000 0 -0.29 176 176
Gq family/GDP/G beta5/gamma2 -0.052 0.11 -10000 0 -0.55 6 6
TXA2/TP beta/beta Arrestin2 -0.019 0.03 -10000 0 -0.33 1 1
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.2 0.12 -10000 0 -10000 0 0
mol:DAG -0.12 0.16 -10000 0 -0.42 18 18
EGFR 0.002 0.099 -10000 0 -0.65 5 5
TXA2/TP alpha -0.16 0.19 -10000 0 -0.51 16 16
Gq family/GTP 0.001 0.077 -10000 0 -0.25 14 14
YES1 -0.12 0.095 -10000 0 -10000 0 0
GNAI2/GTP -0.15 0.081 -10000 0 -10000 0 0
PGD2/DP -0.37 0.19 -10000 0 -0.47 176 176
SLC9A3R1 0.005 0.086 -10000 0 -0.63 4 4
FYN -0.12 0.097 -10000 0 -0.46 1 1
mol:NO 0.013 0.049 -10000 0 -0.72 1 1
GNA15 -0.006 0.13 -10000 0 -0.72 7 7
PGK/cGMP -0.002 0.031 -10000 0 -0.47 1 1
RhoA/GDP 0.018 0.001 -10000 0 -10000 0 0
TP alpha/TGM2/GDP/G beta/gamma -0.2 0.14 -10000 0 -0.58 17 17
NOS3 0.013 0.049 -10000 0 -0.72 1 1
RAC1 0.017 0 -10000 0 -10000 0 0
PRKCA -0.097 0.14 -10000 0 -0.37 10 10
PRKCB -0.1 0.14 -10000 0 -0.35 18 18
PRKCE -0.095 0.14 -10000 0 -0.38 7 7
PRKCD -0.098 0.14 -10000 0 -0.38 10 10
PRKCG -0.11 0.15 -10000 0 -0.43 14 14
muscle contraction -0.14 0.18 -10000 0 -0.5 15 15
PRKCZ -0.1 0.14 -10000 0 -0.36 13 13
ARR3 0.017 0 -10000 0 -10000 0 0
TXA2/TP beta -0.18 0.091 -10000 0 -10000 0 0
PRKCQ -0.1 0.14 -10000 0 -0.39 12 12
MAPKKK cascade -0.13 0.17 -10000 0 -0.46 16 16
SELE -0.1 0.15 -10000 0 -0.36 33 33
TP beta/GNAI2/GDP/G beta/gamma -0.16 0.086 -10000 0 -10000 0 0
ROCK1 0.017 0 -10000 0 -10000 0 0
GNA14 -0.009 0.13 -10000 0 -0.63 9 9
chemotaxis -0.16 0.21 -10000 0 -0.59 15 15
GNA12 0.017 0 -10000 0 -10000 0 0
GNA13 0.017 0 -10000 0 -10000 0 0
GNA11 0 0.1 -10000 0 -0.63 6 6
Rac1/GTP 0 0 -10000 0 -10000 0 0
Ephrin B reverse signaling

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.011 0.065 -10000 0 -0.68 2 2
EPHB2 -0.004 0.12 -10000 0 -0.71 6 6
EFNB1 0.022 0.053 -10000 0 -0.54 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.14 0.19 -10000 0 -0.7 7 7
Ephrin B2/EPHB1-2 -0.17 0.22 -10000 0 -0.44 85 85
neuron projection morphogenesis -0.14 0.18 -10000 0 -0.66 7 7
Ephrin B1/EPHB1-2/Tiam1 -0.15 0.21 -10000 0 -0.75 7 7
DNM1 0.009 0.069 -10000 0 -0.72 2 2
cell-cell signaling -0.003 0.004 -10000 0 -10000 0 0
MAP2K4 -0.064 0.15 -10000 0 -0.75 5 5
YES1 -0.093 0.18 -10000 0 -1 4 4
Ephrin B1/EPHB1-2/NCK2 -0.15 0.2 -10000 0 -0.77 5 5
PI3K -0.058 0.15 -10000 0 -0.81 4 4
mol:GDP -0.15 0.21 -10000 0 -0.74 7 7
ITGA2B 0.017 0 -10000 0 -10000 0 0
endothelial cell proliferation -0.087 0.19 -10000 0 -0.48 41 41
FYN -0.094 0.18 -10000 0 -0.91 5 5
MAP3K7 -0.081 0.15 -10000 0 -0.85 4 4
FGR -0.095 0.18 -10000 0 -1 4 4
TIAM1 0.011 0.061 -10000 0 -0.63 2 2
PIK3R1 0.017 0 -10000 0 -10000 0 0
RGS3 0.017 0 -10000 0 -10000 0 0
cell adhesion -0.033 0.14 -10000 0 -0.73 4 4
LYN -0.093 0.18 -10000 0 -1 4 4
Ephrin B1/EPHB1-2/Src Family Kinases -0.088 0.16 -10000 0 -0.97 4 4
Ephrin B1/EPHB1-2 -0.098 0.16 -10000 0 -0.71 6 6
SRC -0.095 0.18 -10000 0 -1 4 4
ITGB3 0.017 0 -10000 0 -10000 0 0
EPHB1 -0.26 0.36 -10000 0 -0.72 82 82
EPHB4 -0.12 0.28 -10000 0 -0.72 40 40
RAC1 0.017 0 -10000 0 -10000 0 0
Ephrin B2/EPHB4 -0.088 0.19 -10000 0 -0.48 41 41
alphaIIb/beta3 Integrin 0 0 -10000 0 -10000 0 0
BLK -0.14 0.19 -10000 0 -0.56 21 21
HCK -0.11 0.19 -10000 0 -0.78 8 8
regulation of stress fiber formation 0.15 0.2 0.76 5 -10000 0 5
MAPK8 -0.05 0.14 -10000 0 -0.7 5 5
Ephrin B1/EPHB1-2/RGS3 -0.15 0.2 -10000 0 -0.77 5 5
endothelial cell migration -0.14 0.2 -10000 0 -0.48 43 43
NCK2 0.017 0 -10000 0 -10000 0 0
PTPN13 -0.2 0.32 -10000 0 -0.68 70 70
regulation of focal adhesion formation 0.15 0.2 0.76 5 -10000 0 5
chemotaxis 0.15 0.2 0.76 5 -10000 0 5
PIK3CA 0.017 0 -10000 0 -10000 0 0
Rac1/GTP -0.14 0.19 -10000 0 -0.69 7 7
angiogenesis -0.098 0.16 -10000 0 -0.91 4 4
LCK -0.096 0.18 -10000 0 -0.9 5 5
Visual signal transduction: Cones

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin -0.007 0.05 -9999 0 -0.4 3 3
RGS9BP -0.003 0.12 -9999 0 -0.72 6 6
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
mol:Na + -0.14 0.19 -9999 0 -0.4 77 77
mol:ADP 0.013 0.038 -9999 0 -0.55 1 1
GNAT2 0.007 0.085 -9999 0 -0.72 3 3
RGS9-1/Gbeta5/R9AP -0.15 0.2 -9999 0 -0.54 9 9
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP -0.008 0.06 -9999 0 -0.45 4 4
GRK7 0.014 0.049 -9999 0 -0.72 1 1
CNGB3 -0.006 0.13 -9999 0 -0.72 7 7
Cone Metarhodopsin II/X-Arrestin 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.1 0.19 -9999 0 -0.47 7 7
Cone PDE6 -0.12 0.16 -9999 0 -0.71 2 2
Cone Metarhodopsin II -0.002 0.029 -9999 0 -0.44 1 1
Na + (4 Units) -0.12 0.17 -9999 0 -0.46 7 7
GNAT2/GDP -0.13 0.17 -9999 0 -0.72 3 3
GNB5 0.007 0.085 -9999 0 -0.72 3 3
mol:GMP (4 units) 0.025 0.065 -9999 0 -0.42 4 4
Cone Transducin -0.007 0.053 -9999 0 -0.42 3 3
SLC24A2 0.017 0 -9999 0 -10000 0 0
GNB3/GNGT2 -0.002 0.031 -9999 0 -0.46 1 1
GNB3 0.017 0 -9999 0 -10000 0 0
GNAT2/GTP -0.007 0.063 -9999 0 -0.55 3 3
CNGA3 -0.19 0.3 -9999 0 -0.63 71 71
ARR3 0.017 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel -0.14 0.2 -9999 0 -0.41 77 77
mol:Pi -0.15 0.2 -9999 0 -0.53 9 9
Cone CNG Channel -0.11 0.16 -9999 0 -0.66 2 2
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + 0.017 0 -9999 0 -10000 0 0
RGS9 -0.2 0.31 -9999 0 -0.63 75 75
PDE6C 0.014 0.049 -9999 0 -0.72 1 1
GNGT2 0.014 0.043 -9999 0 -0.63 1 1
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H 0.014 0.043 -9999 0 -0.63 1 1
Nectin adhesion pathway

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.017 0 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.002 0.036 -9999 0 -0.54 1 1
PTK2 -0.021 0.085 -9999 0 -10000 0 0
positive regulation of JNK cascade -0.015 0.062 -9999 0 -10000 0 0
CDC42/GDP 0.056 0.1 -9999 0 -0.39 11 11
Rac1/GDP 0.058 0.1 -9999 0 -0.39 11 11
RAP1B 0.017 0 -9999 0 -10000 0 0
RAP1A 0.017 0 -9999 0 -10000 0 0
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
CDC42/GTP -0.018 0.076 -9999 0 -0.35 11 11
nectin-3/I-afadin -0.023 0.099 -9999 0 -0.46 11 11
RAPGEF1 0.051 0.11 -9999 0 -0.42 11 11
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.042 0.12 -9999 0 -0.49 11 11
PDGFB-D/PDGFRB 0.017 0 -9999 0 -10000 0 0
TLN1 0.036 0.047 -9999 0 -10000 0 0
Rap1/GTP -0.016 0.065 -9999 0 -10000 0 0
IQGAP1 0.017 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0 0 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.023 0.099 -9999 0 -0.46 11 11
PVR 0.014 0.049 -9999 0 -0.72 1 1
Necl-5(dimer) 0.014 0.049 -9999 0 -0.72 1 1
mol:GDP 0.052 0.12 -9999 0 -0.48 11 11
MLLT4 0.017 0 -9999 0 -10000 0 0
PIK3CA 0.017 0 -9999 0 -10000 0 0
PI3K -0.015 0.067 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0 0 -9999 0 -10000 0 0
positive regulation of lamellipodium assembly -0.019 0.073 -9999 0 -0.32 11 11
PVRL1 0.017 0 -9999 0 -10000 0 0
PVRL3 -0.015 0.14 -9999 0 -0.63 11 11
PVRL2 0.014 0.049 -9999 0 -0.72 1 1
PIK3R1 0.017 0 -9999 0 -10000 0 0
CDH1 0 0.1 -9999 0 -0.63 6 6
CLDN1 -0.7 0.14 -9999 0 -0.72 216 216
JAM-A/CLDN1 -0.41 0.11 -9999 0 -0.43 216 216
SRC -0.028 0.12 -9999 0 -0.55 11 11
ITGB3 0.017 0 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin 0 0 -9999 0 -10000 0 0
FARP2 0.047 0.12 -9999 0 -0.46 11 11
RAC1 0.017 0 -9999 0 -10000 0 0
CTNNA1 0.017 0 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) -0.021 0.088 -9999 0 -0.39 12 12
nectin-1/I-afadin 0 0 -9999 0 -10000 0 0
nectin-2/I-afadin -0.002 0.036 -9999 0 -0.54 1 1
RAC1/GTP/IQGAP1/filamentous actin 0 0 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.019 0.083 -9999 0 -0.38 11 11
CDC42/GTP/IQGAP1/filamentous actin 0 0 -9999 0 -10000 0 0
F11R 0.017 0 -9999 0 -10000 0 0
positive regulation of filopodium formation -0.015 0.062 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Talin 0.05 0.05 -9999 0 -10000 0 0
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.036 -9999 0 -0.54 1 1
nectin-2(dimer)/I-afadin/I-afadin -0.002 0.036 -9999 0 -0.54 1 1
PIP5K1C 0.026 0.05 -9999 0 -10000 0 0
VAV2 0.037 0.14 -9999 0 -0.49 14 14
RAP1/GDP -0.018 0.077 -9999 0 -0.42 1 1
ITGAV 0.014 0.049 -9999 0 -0.72 1 1
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin -0.021 0.088 -9999 0 -0.39 12 12
nectin-3(dimer)/I-afadin/I-afadin -0.023 0.099 -9999 0 -0.46 11 11
Rac1/GTP -0.023 0.089 -9999 0 -0.38 11 11
PTPRM -0.011 0.049 -9999 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin -0.019 0.076 -9999 0 -10000 0 0
adherens junction assembly 0 0 -9999 0 -10000 0 0
CDC42 0.017 0 -9999 0 -10000 0 0
Ceramide signaling pathway

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.018 0.079 -10000 0 -0.46 6 6
MAP4K4 0.045 0.083 -10000 0 -0.58 1 1
BAG4 0.017 0 -10000 0 -10000 0 0
PKC zeta/ceramide -0.042 0.056 0.18 1 -10000 0 1
NFKBIA 0.017 0 -10000 0 -10000 0 0
BIRC3 -0.019 0.15 -10000 0 -0.66 12 12
BAX -0.011 0.032 -10000 0 -0.23 1 1
RIPK1 0.017 0 -10000 0 -10000 0 0
AKT1 0.034 0.011 -10000 0 -10000 0 0
BAD -0.03 0.057 0.2 1 -10000 0 1
SMPD1 -0.027 0.13 -10000 0 -0.27 47 47
RB1 -0.03 0.057 0.2 1 -10000 0 1
FADD/Caspase 8 0.066 0.054 -10000 0 -10000 0 0
MAP2K4 -0.025 0.072 -10000 0 -0.37 4 4
NSMAF 0.017 0 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.019 0.054 -10000 0 -10000 0 0
EGF -0.18 0.31 -10000 0 -0.67 65 65
mol:ceramide -0.044 0.061 0.18 5 -10000 0 5
MADD 0.017 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid 0.02 0.072 -10000 0 -0.46 5 5
ASAH1 0.017 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.03 0.056 0.2 1 -10000 0 1
cell proliferation -0.16 0.14 -10000 0 -0.34 35 35
BID 0.023 0.067 -10000 0 -0.37 2 2
MAP3K1 -0.03 0.057 0.2 1 -10000 0 1
EIF2A -0.055 0.14 -10000 0 -0.42 25 25
TRADD 0.017 0 -10000 0 -10000 0 0
CRADD 0.011 0.061 -10000 0 -0.63 2 2
MAPK3 -0.003 0.052 -10000 0 -10000 0 0
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.003 0.05 -10000 0 -10000 0 0
Cathepsin D/ceramide -0.032 0.063 0.19 1 -0.47 1 2
FADD 0.053 0.057 -10000 0 -10000 0 0
KSR1 -0.03 0.057 0.2 1 -10000 0 1
MAPK8 -0.022 0.06 0.2 1 -0.25 3 4
PRKRA -0.03 0.057 0.2 1 -10000 0 1
PDGFA 0.002 0.096 -10000 0 -0.63 5 5
TRAF2 0.017 0 -10000 0 -10000 0 0
IGF1 -0.35 0.32 -10000 0 -0.63 126 126
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.044 0.061 0.18 5 -10000 0 5
CTSD 0.014 0.043 -10000 0 -0.63 1 1
regulation of nitric oxide biosynthetic process 0 0 -10000 0 -10000 0 0
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.16 0.16 -10000 0 -0.38 15 15
PRKCD 0.017 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine 0.02 0.072 -10000 0 -0.46 5 5
RelA/NF kappa B1 0 0 -10000 0 -10000 0 0
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.017 0 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.044 0.06 -10000 0 -10000 0 0
TNFR1A/BAG4/TNF-alpha 0 0 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate 0.018 0.079 -10000 0 -0.46 6 6
MAP2K1 -0.007 0.052 -10000 0 -10000 0 0
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.017 0 -10000 0 -10000 0 0
CYCS 0.09 0.088 0.17 91 -10000 0 91
TNFRSF1A 0.017 0 -10000 0 -10000 0 0
NFKB1 0.017 0 -10000 0 -10000 0 0
TNFR1A/BAG4 0 0 -10000 0 -10000 0 0
EIF2AK2 -0.031 0.088 -10000 0 -0.45 6 6
TNF-alpha/TNFR1A/FAN 0 0 -10000 0 -10000 0 0
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.052 0.036 -10000 0 -10000 0 0
MAP2K2 -0.007 0.052 -10000 0 -10000 0 0
SMPD3 0.029 0.072 -10000 0 -0.35 7 7
TNF 0.017 0 -10000 0 -10000 0 0
PKC zeta/PAR4 0 0 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE 0.059 0.11 0.23 69 -10000 0 69
NF kappa B1/RelA/I kappa B alpha 0 0 -10000 0 -10000 0 0
AIFM1 0.09 0.089 0.17 92 -10000 0 92
BCL2 -0.41 0.31 -10000 0 -0.63 147 147
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.014 0.049 -10000 0 -0.72 1 1
NFATC1 0.058 0.046 -10000 0 -10000 0 0
NFATC2 0.034 0.048 -10000 0 -10000 0 0
NFATC3 0.021 0.002 -10000 0 -10000 0 0
YWHAE 0.014 0.049 -10000 0 -0.72 1 1
Calcineurin A alpha-beta B1/CABIN1 -0.1 0.14 -10000 0 -0.44 10 10
Exportin 1/Ran/NUP214 -0.002 0.03 -10000 0 -0.46 1 1
mol:DAG 0.001 0.001 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV -0.093 0.091 -10000 0 -0.49 3 3
BCL2/BAX -0.3 0.22 -10000 0 -0.46 148 148
CaM/Ca2+/Calcineurin A alpha-beta B1 0.015 0.002 -10000 0 -10000 0 0
CaM/Ca2+ 0.015 0.002 -10000 0 -10000 0 0
BAX 0.014 0.049 -10000 0 -0.72 1 1
MAPK14 0.017 0.002 -10000 0 -10000 0 0
BAD 0.017 0 -10000 0 -10000 0 0
CABIN1/MEF2D -0.09 0.14 -10000 0 -0.52 4 4
Calcineurin A alpha-beta B1/BCL2 -0.41 0.31 -10000 0 -0.63 147 147
FKBP8 0.017 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.089 0.14 0.52 4 -10000 0 4
KPNB1 -0.003 0.12 -10000 0 -0.72 6 6
KPNA2 -0.013 0.14 -10000 0 -0.72 9 9
XPO1 0.017 0 -10000 0 -10000 0 0
SFN 0.011 0.061 -10000 0 -0.63 2 2
MAP3K8 -0.088 0.26 -10000 0 -0.72 32 32
NFAT4/CK1 alpha 0 0 -10000 0 -10000 0 0
MEF2D/NFAT1/Cbp/p300 -0.005 0.027 -10000 0 -10000 0 0
CABIN1 -0.11 0.15 -10000 0 -0.44 10 10
CALM1 0.018 0.002 -10000 0 -10000 0 0
RAN 0.014 0.049 -10000 0 -0.72 1 1
MAP3K1 0.017 0 -10000 0 -10000 0 0
CAMK4 0.017 0 -10000 0 -10000 0 0
mol:Ca2+ 0.002 0.002 -10000 0 -10000 0 0
MAPK3 0.011 0.061 -10000 0 -0.63 2 2
YWHAH 0.017 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/AKAP79/PKA -0.008 0.061 -10000 0 -0.46 4 4
YWHAB 0.017 0 -10000 0 -10000 0 0
MAPK8 0.018 0.002 -10000 0 -10000 0 0
MAPK9 0.017 0 -10000 0 -10000 0 0
YWHAG 0.017 0 -10000 0 -10000 0 0
FKBP1A 0.017 0 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ 0.001 0.023 -10000 0 -10000 0 0
PRKCH 0.008 0.075 -10000 0 -0.63 3 3
CABIN1/Cbp/p300 0 0 -10000 0 -10000 0 0
CASP3 0.015 0.043 -10000 0 -0.63 1 1
PIM1 0.017 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0 0 -10000 0 -10000 0 0
apoptosis -0.09 0.065 -10000 0 -10000 0 0
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.057 0.024 -10000 0 -10000 0 0
PRKCB 0 0 -10000 0 -10000 0 0
PRKCE 0.017 0 -10000 0 -10000 0 0
JNK2/NFAT4 0.029 0.003 -10000 0 -10000 0 0
BAD/BCL-XL -0.002 0.036 -10000 0 -0.54 1 1
PRKCD 0.017 0 -10000 0 -10000 0 0
NUP214 0.017 0 -10000 0 -10000 0 0
PRKCZ 0.001 0.001 -10000 0 -10000 0 0
PRKCA 0.014 0.049 -10000 0 -0.72 1 1
PRKCG 0.004 0.098 -10000 0 -0.72 4 4
PRKCQ -0.003 0.12 -10000 0 -0.72 6 6
FKBP38/BCL2 -0.3 0.22 -10000 0 -0.46 147 147
EP300 0.018 0.001 -10000 0 -10000 0 0
PRKCB1 -0.36 0.32 -10000 0 -0.63 129 129
CSNK2A1 0.017 0 -10000 0 -10000 0 0
NFATc/JNK1 0.066 0.045 -10000 0 -10000 0 0
CaM/Ca2+/FKBP38 0 0 -10000 0 -10000 0 0
FKBP12/FK506 0 0 -10000 0 -10000 0 0
CSNK1A1 0.028 0.003 -10000 0 -10000 0 0
CaM/Ca2+/CAMK IV 0 0 -10000 0 -10000 0 0
NFATc/ERK1 0.062 0.053 -10000 0 -10000 0 0
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV -0.094 0.091 -10000 0 -0.49 3 3
NR4A1 0.073 0.071 -10000 0 -0.57 2 2
GSK3B 0.014 0.049 -10000 0 -0.72 1 1
positive T cell selection 0.021 0.002 -10000 0 -10000 0 0
NFAT1/CK1 alpha -0.008 0.021 -10000 0 -10000 0 0
RCH1/ KPNB1 -0.036 0.14 -10000 0 -0.57 14 14
YWHAQ 0.017 0 -10000 0 -10000 0 0
PRKACA 0.017 0.002 -10000 0 -10000 0 0
AKAP5 0.005 0.086 -10000 0 -0.63 4 4
MEF2D 0.018 0.001 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.017 0 -10000 0 -10000 0 0
NFATc/p38 alpha 0.066 0.045 -10000 0 -10000 0 0
CREBBP 0.018 0.001 -10000 0 -10000 0 0
BCL2 -0.41 0.31 -10000 0 -0.63 147 147
Signaling events mediated by the Hedgehog family

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 0.017 0.23 -10000 0 -0.69 19 19
IHH 0.021 0.063 -10000 0 -0.79 1 1
SHH Np/Cholesterol/GAS1 -0.16 0.21 -10000 0 -0.61 17 17
LRPAP1 0.017 0 -10000 0 -10000 0 0
dorsoventral neural tube patterning 0.16 0.21 0.61 17 -10000 0 17
SMO/beta Arrestin2 0.047 0.1 -10000 0 -0.7 1 1
SMO 0.04 0.11 -10000 0 -0.75 1 1
AKT1 0.051 0.053 -10000 0 -10000 0 0
ARRB2 0.017 0 -10000 0 -10000 0 0
BOC 0.017 0 -10000 0 -10000 0 0
ADRBK1 0.017 0 -10000 0 -10000 0 0
heart looping 0.04 0.1 -10000 0 -0.73 1 1
STIL -0.047 0.21 -10000 0 -0.63 12 12
DHH N/PTCH2 0 0 -10000 0 -10000 0 0
DHH N/PTCH1 0.041 0.1 -10000 0 -0.7 1 1
PIK3CA 0.017 0 -10000 0 -10000 0 0
DHH 0.017 0 -10000 0 -10000 0 0
PTHLH 0.028 0.21 -10000 0 -1.2 4 4
determination of left/right symmetry 0.04 0.1 -10000 0 -0.73 1 1
PIK3R1 0.017 0 -10000 0 -10000 0 0
skeletal system development 0.028 0.21 -10000 0 -1.1 4 4
IHH N/Hhip -0.086 0.22 -10000 0 -0.51 48 48
DHH N/Hhip -0.098 0.19 -10000 0 -0.46 48 48
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development 0.04 0.1 -10000 0 -0.73 1 1
pancreas development -0.12 0.27 -10000 0 -0.63 48 48
HHAT -0.053 0.2 -10000 0 -0.63 24 24
PI3K 0 0 -10000 0 -10000 0 0
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.19 0.31 -10000 0 -0.64 71 71
somite specification 0.04 0.1 -10000 0 -0.73 1 1
SHH Np/Cholesterol/PTCH1 0.005 0.15 -10000 0 -0.57 4 4
SHH Np/Cholesterol/PTCH2 -0.043 0.12 -10000 0 -0.53 3 3
SHH Np/Cholesterol/Megalin -0.045 0.12 -10000 0 -0.5 4 4
SHH -0.029 0.17 -10000 0 -0.48 26 26
catabolic process 0.036 0.11 -10000 0 -0.77 1 1
SMO/Vitamin D3 0.016 0.15 -10000 0 -0.64 2 2
SHH Np/Cholesterol/Hhip -0.12 0.21 -10000 0 -0.72 12 12
LRP2 0.014 0.049 -10000 0 -0.72 1 1
receptor-mediated endocytosis -0.05 0.11 -10000 0 -0.6 2 2
SHH Np/Cholesterol/BOC -0.043 0.12 -10000 0 -0.53 3 3
SHH Np/Cholesterol/CDO -0.043 0.12 -10000 0 -0.53 3 3
mesenchymal cell differentiation 0.12 0.2 0.71 12 -10000 0 12
mol:Vitamin D3 0.009 0.15 -10000 0 -0.57 4 4
IHH N/PTCH2 0.029 0.039 -10000 0 -0.5 1 1
CDON 0.017 0 -10000 0 -10000 0 0
IHH N/PTCH1 0.036 0.11 -10000 0 -0.78 1 1
Megalin/LRPAP1 -0.002 0.036 -10000 0 -0.54 1 1
PTCH2 0.017 0 -10000 0 -10000 0 0
SHH Np/Cholesterol -0.044 0.12 -10000 0 -0.38 26 26
PTCH1 0.036 0.11 -10000 0 -0.77 1 1
HHIP -0.12 0.27 -10000 0 -0.63 48 48
ceramide signaling pathway

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 0.046 0.093 -10000 0 -0.63 1 1
BAG4 0.017 0 -10000 0 -10000 0 0
BAD 0.013 0.063 -10000 0 -10000 0 0
NFKBIA 0.017 0 -10000 0 -10000 0 0
BIRC3 -0.019 0.15 -10000 0 -0.66 12 12
BAX 0.011 0.07 -10000 0 -0.48 1 1
EnzymeConsortium:3.1.4.12 0.019 0.018 -10000 0 -10000 0 0
IKBKB 0.053 0.092 -10000 0 -0.58 1 1
MAP2K2 0.034 0.054 -10000 0 -10000 0 0
MAP2K1 0.034 0.054 -10000 0 -10000 0 0
SMPD1 -0.032 0.12 -10000 0 -0.26 47 47
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 0.063 0.069 -10000 0 -10000 0 0
MAP2K4 0.019 0.075 -10000 0 -0.33 4 4
protein ubiquitination 0.057 0.09 -10000 0 -0.59 1 1
EnzymeConsortium:2.7.1.37 0.041 0.055 -10000 0 -10000 0 0
response to UV 0.001 0 -10000 0 -10000 0 0
RAF1 0.025 0.057 -10000 0 -10000 0 0
CRADD 0.011 0.061 -10000 0 -0.63 2 2
mol:ceramide 0.003 0.065 -10000 0 -0.22 4 4
I-kappa-B-alpha/RELA/p50/ubiquitin 0 0 -10000 0 -10000 0 0
MADD 0.017 0 -10000 0 -10000 0 0
MAP3K1 0.014 0.062 -10000 0 -10000 0 0
TRADD 0.017 0 -10000 0 -10000 0 0
RELA/p50 0.017 0 -10000 0 -10000 0 0
MAPK3 0.037 0.054 -10000 0 -10000 0 0
MAPK1 0.038 0.053 -10000 0 -10000 0 0
p50/RELA/I-kappa-B-alpha 0 0 -10000 0 -10000 0 0
FADD 0.053 0.071 -10000 0 -10000 0 0
KSR1 0.015 0.061 -10000 0 -10000 0 0
MAPK8 0.028 0.07 -10000 0 -0.35 2 2
TRAF2 0.017 0 -10000 0 -10000 0 0
response to radiation 0 0 -10000 0 -10000 0 0
CHUK 0.055 0.089 -10000 0 -0.58 1 1
TNF R/SODD 0 0 -10000 0 -10000 0 0
TNF 0.017 0 -10000 0 -10000 0 0
CYCS 0.085 0.084 0.16 109 -0.27 1 110
IKBKG 0.055 0.089 -10000 0 -0.58 1 1
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD 0.044 0.074 -10000 0 -10000 0 0
RELA 0.017 0 -10000 0 -10000 0 0
RIPK1 0.017 0 -10000 0 -10000 0 0
AIFM1 0.085 0.084 0.16 110 -0.27 1 111
TNF/TNF R/SODD 0 0 -10000 0 -10000 0 0
TNFRSF1A 0.017 0 -10000 0 -10000 0 0
response to heat 0 0 -10000 0 -10000 0 0
CASP8 0.037 0.02 -10000 0 -10000 0 0
NSMAF 0.054 0.069 -10000 0 -10000 0 0
response to hydrogen peroxide 0.001 0 -10000 0 -10000 0 0
BCL2 -0.41 0.31 -10000 0 -0.63 147 147
Glypican 2 network

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK -0.023 0.17 -9999 0 -0.72 12 12
GPC2 0 0 -9999 0 -10000 0 0
GPC2/Midkine -0.029 0.12 -9999 0 -0.55 12 12
neuron projection morphogenesis -0.029 0.12 -9999 0 -0.55 12 12
Regulation of Telomerase

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.095 0.15 -9999 0 -10000 0 0
RAD9A 0.017 0 -9999 0 -10000 0 0
AP1 -0.077 0.18 -9999 0 -0.48 37 37
IFNAR2 0.017 0.007 -9999 0 -10000 0 0
AKT1 0.025 0.043 -9999 0 -10000 0 0
ER alpha/Oestrogen -0.013 0.076 -9999 0 -0.47 6 6
NFX1/SIN3/HDAC complex 0.056 0.029 -9999 0 -10000 0 0
EGF -0.18 0.31 -9999 0 -0.67 65 65
SMG5 0.017 0 -9999 0 -10000 0 0
SMG6 0.017 0 -9999 0 -10000 0 0
SP3/HDAC2 0.02 0.015 -9999 0 -10000 0 0
TERT/c-Abl -0.092 0.13 -9999 0 -10000 0 0
SAP18 0.014 0.049 -9999 0 -0.72 1 1
MRN complex 0 0 -9999 0 -10000 0 0
WT1 -0.39 0.37 -9999 0 -0.72 123 123
WRN 0.017 0 -9999 0 -10000 0 0
SP1 0.018 0.008 -9999 0 -10000 0 0
SP3 0.016 0.006 -9999 0 -10000 0 0
TERF2IP 0.017 0 -9999 0 -10000 0 0
Telomerase/Nucleolin -0.18 0.2 -9999 0 -0.64 12 12
Mad/Max -0.021 0.1 -9999 0 -0.46 12 12
TERT -0.097 0.15 -9999 0 -10000 0 0
CCND1 -0.12 0.23 -9999 0 -0.69 12 12
MAX 0.016 0.006 -9999 0 -10000 0 0
RBBP7 0.017 0.001 -9999 0 -10000 0 0
RBBP4 0.017 0.001 -9999 0 -10000 0 0
TERF2 0 0 -9999 0 -10000 0 0
PTGES3 0.017 0 -9999 0 -10000 0 0
SIN3A 0.017 0.001 -9999 0 -10000 0 0
Telomerase/911 -0.058 0.14 -9999 0 -0.5 1 1
CDKN1B -0.062 0.21 -9999 0 -0.75 2 2
RAD1 -0.013 0.14 -9999 0 -0.72 9 9
XRCC5 0.017 0 -9999 0 -10000 0 0
XRCC6 0.017 0 -9999 0 -10000 0 0
SAP30 0.017 0.001 -9999 0 -10000 0 0
TRF2/PARP2 0 0 -9999 0 -10000 0 0
UBE3A 0.016 0.005 -9999 0 -10000 0 0
JUN 0 0.11 -9999 0 -0.72 5 5
E6 0 0.002 -9999 0 -10000 0 0
HPV-16 E6/E6AP 0.013 0.006 -9999 0 -10000 0 0
FOS -0.08 0.23 -9999 0 -0.64 33 33
IFN-gamma/IRF1 -0.12 0.22 -9999 0 -0.52 51 51
PARP2 0.017 0 -9999 0 -10000 0 0
BLM 0.007 0.085 -9999 0 -0.72 3 3
Telomerase -0.064 0.15 -9999 0 -0.49 1 1
IRF1 0.015 0.066 -9999 0 -0.67 2 2
ESR1 0 0.1 -9999 0 -0.63 6 6
KU/TER 0 0 -9999 0 -10000 0 0
ATM/TRF2 0 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.061 0.033 -9999 0 -10000 0 0
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.061 0.033 -9999 0 -10000 0 0
HDAC1 0.017 0.001 -9999 0 -10000 0 0
HDAC2 0.017 0.007 -9999 0 -10000 0 0
ATM 0 0 -9999 0 -10000 0 0
SMAD3 0.026 0.046 -9999 0 -0.46 2 2
ABL1 0.017 0 -9999 0 -10000 0 0
MXD1 -0.019 0.15 -9999 0 -0.63 12 12
MRE11A 0.017 0 -9999 0 -10000 0 0
HUS1 0.017 0 -9999 0 -10000 0 0
RPS6KB1 0.014 0.049 -9999 0 -0.72 1 1
TERT/NF kappa B1/14-3-3 -0.066 0.12 -9999 0 -10000 0 0
NR2F2 0.016 0.005 -9999 0 -10000 0 0
MAPK3 0.027 0.047 -9999 0 -0.46 2 2
MAPK1 0.029 0.034 -9999 0 -0.47 1 1
TGFB1/TGF beta receptor Type II 0.017 0.001 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
HNRNPC 0.017 0 -9999 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0 0 -9999 0 -10000 0 0
NBN 0.017 0 -9999 0 -10000 0 0
EGFR 0.002 0.099 -9999 0 -0.65 5 5
mol:Oestrogen 0 0.002 -9999 0 -10000 0 0
EGF/EGFR -0.15 0.23 -9999 0 -0.5 69 69
MYC -0.42 0.36 -9999 0 -0.72 133 133
IL2 0.018 0.008 -9999 0 -10000 0 0
KU 0 0 -9999 0 -10000 0 0
RAD50 0.017 0 -9999 0 -10000 0 0
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
TGFB1 0.017 0.001 -9999 0 -10000 0 0
TRF2/BLM -0.007 0.058 -9999 0 -0.5 3 3
FRAP1 0.017 0 -9999 0 -10000 0 0
KU/TERT -0.08 0.13 -9999 0 -10000 0 0
SP1/HDAC2 0.029 0.012 -9999 0 -10000 0 0
PINX1 0.014 0.049 -9999 0 -0.72 1 1
Telomerase/EST1A -0.18 0.2 -9999 0 -0.66 9 9
Smad3/Myc -0.26 0.25 -9999 0 -0.46 133 133
911 complex -0.018 0.09 -9999 0 -0.46 9 9
IFNG -0.14 0.3 -9999 0 -0.71 50 50
Telomerase/PinX1 -0.18 0.2 -9999 0 -0.64 12 12
Telomerase/AKT1/mTOR/p70S6K -0.045 0.12 -9999 0 -10000 0 0
SIN3B 0.017 0.001 -9999 0 -10000 0 0
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
Telomerase/EST1B -0.18 0.2 -9999 0 -0.64 12 12
response to DNA damage stimulus 0.005 0 -9999 0 -10000 0 0
MRN complex/TRF2/Rap1 0 0 -9999 0 -10000 0 0
TRF2/WRN 0 0 -9999 0 -10000 0 0
Telomerase/hnRNP C1/C2 -0.18 0.2 -9999 0 -0.64 12 12
E2F1 -0.029 0.18 -9999 0 -0.72 14 14
ZNFX1 0.014 0.049 -9999 0 -0.72 1 1
PIF1 0.004 0.098 -9999 0 -0.72 4 4
NCL 0.017 0 -9999 0 -10000 0 0
DKC1 -0.2 0.34 -9999 0 -0.72 67 67
telomeric DNA binding 0 0 -9999 0 -10000 0 0
Syndecan-4-mediated signaling events

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.002 0.12 -9999 0 -0.39 3 3
Syndecan-4/Syndesmos 0.028 0.11 -9999 0 -0.48 4 4
positive regulation of JNK cascade -0.23 0.14 -9999 0 -0.54 25 25
Syndecan-4/ADAM12 -0.12 0.25 -9999 0 -0.61 25 25
CCL5 -0.14 0.28 -9999 0 -0.63 53 53
Rac1/GDP 0 0 -9999 0 -10000 0 0
DNM2 0.017 0 -9999 0 -10000 0 0
ITGA5 0 0.11 -9999 0 -0.72 5 5
SDCBP 0.017 0 -9999 0 -10000 0 0
PLG 0.013 0.006 -9999 0 -10000 0 0
ADAM12 -0.26 0.36 -9999 0 -0.72 84 84
mol:GTP 0 0 -9999 0 -10000 0 0
NUDT16L1 0.017 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
Syndecan-4/PKC alpha -0.017 0.042 -9999 0 -10000 0 0
Syndecan-4/Laminin alpha1 0.028 0.11 -9999 0 -0.48 4 4
Syndecan-4/CXCL12/CXCR4 -0.24 0.15 -9999 0 -0.57 25 25
Syndecan-4/Laminin alpha3 0.02 0.13 -9999 0 -0.56 5 5
MDK -0.023 0.17 -9999 0 -0.72 12 12
Syndecan-4/FZD7 0.012 0.13 -9999 0 -0.48 4 4
Syndecan-4/Midkine 0.007 0.15 -9999 0 -0.53 7 7
FZD7 -0.012 0.14 -9999 0 -0.7 9 9
Syndecan-4/FGFR1/FGF -0.039 0.09 -9999 0 -10000 0 0
THBS1 0.011 0.065 -9999 0 -0.68 2 2
integrin-mediated signaling pathway 0.019 0.14 -9999 0 -0.56 7 7
positive regulation of MAPKKK cascade -0.23 0.14 -9999 0 -0.54 25 25
Syndecan-4/TACI 0.022 0.12 -9999 0 -0.5 5 5
CXCR4 -0.019 0.16 -9999 0 -0.72 11 11
cell adhesion -0.034 0.093 -9999 0 -0.41 3 3
Syndecan-4/Dynamin 0.028 0.11 -9999 0 -0.48 4 4
Syndecan-4/TSP1 0.025 0.12 -9999 0 -0.57 4 4
Syndecan-4/GIPC 0.026 0.12 -9999 0 -0.49 5 5
Syndecan-4/RANTES -0.051 0.18 -9999 0 -0.54 12 12
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
LAMA1 0.017 0 -9999 0 -10000 0 0
LAMA3 0.002 0.1 -9999 0 -0.67 5 5
RAC1 0.017 0 -9999 0 -10000 0 0
PRKCA 0.01 0.058 -9999 0 -0.7 1 1
Syndecan-4/alpha-Actinin 0.028 0.11 -9999 0 -0.48 4 4
TFPI 0.014 0.049 -9999 0 -0.72 1 1
F2 0.019 0.004 -9999 0 -10000 0 0
alpha5/beta1 Integrin -0.014 0.087 -9999 0 -0.54 6 6
positive regulation of cell adhesion 0.03 0.13 -9999 0 -0.65 2 2
ACTN1 0.017 0 -9999 0 -10000 0 0
TNC 0 0.11 -9999 0 -0.72 5 5
Syndecan-4/CXCL12 -0.23 0.15 -9999 0 -0.53 18 18
FGF6 0.014 0.049 -9999 0 -0.72 1 1
RHOA 0.017 0 -9999 0 -10000 0 0
CXCL12 -0.48 0.28 -9999 0 -0.63 170 170
TNFRSF13B 0.005 0.086 -9999 0 -0.63 4 4
FGF2 -0.01 0.13 -9999 0 -0.64 9 9
FGFR1 0.017 0 -9999 0 -10000 0 0
Syndecan-4/PI-4-5-P2 0.017 0.11 -9999 0 -0.49 4 4
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.073 0.24 -9999 0 -0.74 26 26
cell migration -0.006 0.016 -9999 0 -10000 0 0
PRKCD 0.013 0.006 -9999 0 -10000 0 0
vasculogenesis 0.025 0.12 -9999 0 -0.55 4 4
SDC4 0.019 0.12 -9999 0 -0.52 4 4
Syndecan-4/Tenascin C 0.019 0.14 -9999 0 -0.59 7 7
Syndecan-4/PI-4-5-P2/PKC alpha -0.013 0.033 -9999 0 -10000 0 0
Syndecan-4/Syntenin 0.028 0.11 -9999 0 -0.48 4 4
MMP9 -0.003 0.13 -9999 0 -0.7 7 7
Rac1/GTP -0.035 0.095 -9999 0 -0.42 3 3
cytoskeleton organization 0.027 0.11 -9999 0 -0.47 4 4
GIPC1 0.014 0.043 -9999 0 -0.63 1 1
Syndecan-4/TFPI 0.026 0.12 -9999 0 -0.5 5 5
Aurora B signaling

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex 0.015 0.085 -9999 0 -0.42 4 4
STMN1 0.03 0.039 -9999 0 -0.55 1 1
Aurora B/RasGAP/Survivin -0.032 0.16 -9999 0 -0.47 24 24
Chromosomal passenger complex/Cul3 protein complex -0.065 0.15 -9999 0 -0.45 14 14
BIRC5 -0.062 0.22 -9999 0 -0.73 23 23
DES -0.031 0.15 -9999 0 -0.67 11 11
Aurora C/Aurora B/INCENP 0.013 0.054 -9999 0 -0.42 3 3
Aurora B/TACC1 0.015 0.015 -9999 0 -10000 0 0
Aurora B/PP2A 0.017 0.016 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CBX5 0.02 0.029 -9999 0 -0.23 3 3
mitotic metaphase/anaphase transition 0.003 0.006 -9999 0 -10000 0 0
NDC80 0.027 0.055 -9999 0 -0.55 2 2
Cul3 protein complex -0.14 0.19 -9999 0 -0.46 15 15
KIF2C -0.029 0.093 -9999 0 -0.3 14 14
PEBP1 0.012 0.008 -9999 0 -10000 0 0
KIF20A -0.07 0.24 -9999 0 -0.72 27 27
mol:GDP 0 0 -9999 0 -10000 0 0
Aurora B/RasGAP 0.012 0.056 -9999 0 -0.55 2 2
SEPT1 0.017 0 -9999 0 -10000 0 0
SMC2 -0.023 0.17 -9999 0 -0.72 12 12
SMC4 0.007 0.085 -9999 0 -0.72 3 3
NSUN2/NPM1/Nucleolin 0.021 0.049 -9999 0 -10000 0 0
PSMA3 0.017 0 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle 0.001 0.006 -9999 0 -10000 0 0
H3F3B 0.025 0.003 -9999 0 -10000 0 0
AURKB 0.021 0.008 -9999 0 -10000 0 0
AURKC 0.017 0 -9999 0 -10000 0 0
CDCA8 0.007 0.071 -9999 0 -0.74 2 2
cytokinesis -0.089 0.17 -9999 0 -0.57 18 18
Aurora B/Septin1 -0.072 0.16 -9999 0 -0.54 16 16
AURKA -0.086 0.26 -9999 0 -0.72 31 31
INCENP 0.003 0.086 -9999 0 -0.74 3 3
KLHL13 -0.21 0.32 -9999 0 -0.65 77 77
BUB1 -0.27 0.36 -9999 0 -0.72 86 86
hSgo1/Aurora B/Survivin -0.048 0.18 -9999 0 -0.48 30 30
EVI5 0.017 0.002 -9999 0 -10000 0 0
RhoA/GTP -0.12 0.22 -9999 0 -0.64 28 28
SGOL1 -0.019 0.16 -9999 0 -0.72 11 11
CENPA -0.058 0.14 -9999 0 -0.36 27 27
NCAPG 0 0 -9999 0 -10000 0 0
Aurora B/HC8 Proteasome 0.017 0.016 -9999 0 -10000 0 0
NCAPD2 0.01 0.07 -9999 0 -0.72 2 2
Aurora B/PP1-gamma 0.017 0.016 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
NCAPH -0.009 0.14 -9999 0 -0.72 8 8
NPM1 0.005 0.024 -9999 0 -10000 0 0
RASA1 0.01 0.07 -9999 0 -0.72 2 2
KLHL9 0.017 0 -9999 0 -10000 0 0
mitotic prometaphase -0.003 0.005 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.017 0.016 -9999 0 -10000 0 0
PPP1CC 0.017 0 -9999 0 -10000 0 0
Centraspindlin -0.13 0.25 -9999 0 -0.64 36 36
RhoA/GDP 0 0 -9999 0 -10000 0 0
NSUN2 0.003 0.03 -9999 0 -10000 0 0
MYLK -0.019 0.12 -9999 0 -0.37 25 25
KIF23 -0.087 0.26 -9999 0 -0.73 31 31
VIM 0.021 0.074 -9999 0 -0.47 5 5
RACGAP1 -0.019 0.15 -9999 0 -0.73 10 10
mitosis 0 0 -9999 0 -10000 0 0
NCL 0.006 0.015 -9999 0 -10000 0 0
Chromosomal passenger complex -0.061 0.15 -9999 0 -0.41 22 22
Chromosomal passenger complex/EVI5 -0.019 0.16 -9999 0 -0.79 3 3
TACC1 0.017 0 -9999 0 -10000 0 0
PPP2R5D 0.017 0 -9999 0 -10000 0 0
CUL3 0.017 0 -9999 0 -10000 0 0
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
PLK2 and PLK4 events

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 -0.006 0.13 -9999 0 -0.72 7 7
PLK4 -0.003 0.12 -9999 0 -0.72 6 6
regulation of centriole replication -0.002 0.13 -9999 0 -0.54 13 13
EPO signaling pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.16 0.18 -9999 0 -0.56 2 2
CRKL -0.01 0.072 -9999 0 -10000 0 0
mol:DAG -0.054 0.12 -9999 0 -0.46 11 11
HRAS 0.024 0.07 -9999 0 -10000 0 0
MAPK8 0.016 0.039 -9999 0 -0.42 1 1
RAP1A -0.01 0.072 -9999 0 -10000 0 0
GAB1 -0.013 0.08 -9999 0 -0.42 1 1
MAPK14 0.016 0.039 -9999 0 -0.42 1 1
EPO 0.004 0.051 -9999 0 -0.74 1 1
PLCG1 -0.056 0.13 -9999 0 -0.47 11 11
EPOR/TRPC2/IP3 Receptors 0.007 0.011 -9999 0 -10000 0 0
RAPGEF1 0.017 0 -9999 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 -0.022 0.1 -9999 0 -0.48 10 10
GAB1/SHC/GRB2/SOS1 -0.014 0.05 -9999 0 -10000 0 0
EPO/EPOR (dimer) 0.008 0.042 -9999 0 -0.56 1 1
IRS2 -0.012 0.077 -9999 0 -0.45 1 1
STAT1 -0.12 0.16 -9999 0 -0.56 11 11
STAT5B -0.065 0.11 -9999 0 -0.47 1 1
cell proliferation 0.019 0.04 -9999 0 -10000 0 0
GAB1/SHIP/PIK3R1/SHP2/SHC -0.015 0.052 -9999 0 -10000 0 0
TEC -0.01 0.072 -9999 0 -10000 0 0
SOCS3 -0.013 0.14 -9999 0 -0.72 9 9
STAT1 (dimer) -0.12 0.16 -9999 0 -0.55 11 11
JAK2 -0.006 0.096 -9999 0 -0.72 4 4
PIK3R1 0.017 0 -9999 0 -10000 0 0
EPO/EPOR (dimer)/JAK2 -0.017 0.081 -9999 0 -0.42 2 2
EPO/EPOR 0.008 0.042 -9999 0 -0.56 1 1
LYN 0.007 0.009 -9999 0 -10000 0 0
TEC/VAV2 -0.005 0.081 -9999 0 -10000 0 0
elevation of cytosolic calcium ion concentration 0.007 0.011 -9999 0 -10000 0 0
SHC1 0.017 0 -9999 0 -10000 0 0
EPO/EPOR (dimer)/LYN 0.015 0.041 -9999 0 -0.48 1 1
mol:IP3 -0.054 0.12 -9999 0 -0.46 11 11
PI3K regualtory subunit polypeptide 1/IRS2/SHIP -0.026 0.052 -9999 0 -10000 0 0
SH2B3 0.006 0.01 -9999 0 -10000 0 0
NFKB1 0.016 0.039 -9999 0 -0.42 1 1
EPO/EPOR (dimer)/JAK2/SOCS3 -0.013 0.054 -9999 0 -0.43 1 1
PTPN6 -0.022 0.074 -9999 0 -0.42 2 2
TEC/VAV2/GRB2 0.004 0.078 -9999 0 -10000 0 0
EPOR 0.007 0.011 -9999 0 -10000 0 0
INPP5D 0 0 -9999 0 -10000 0 0
mol:GDP -0.014 0.051 -9999 0 -10000 0 0
SOS1 0.017 0 -9999 0 -10000 0 0
PLCG2 -0.3 0.32 -9999 0 -0.63 111 111
CRKL/CBL/C3G 0.009 0.068 -9999 0 -10000 0 0
VAV2 -0.016 0.083 -9999 0 -10000 0 0
CBL -0.01 0.072 -9999 0 -0.42 1 1
SHC/Grb2/SOS1 -0.018 0.044 -9999 0 -10000 0 0
STAT5A -0.065 0.11 -9999 0 -0.47 1 1
GRB2 0.017 0 -9999 0 -10000 0 0
STAT5 (dimer) -0.12 0.17 -9999 0 -0.59 1 1
LYN/PLCgamma2 -0.23 0.23 -9999 0 -0.47 111 111
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
BTK -0.064 0.15 -9999 0 -10000 0 0
BCL2 -0.57 0.47 -9999 0 -0.9 147 147
PDGFR-alpha signaling pathway

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.004 0.075 -9999 0 -0.63 3 3
PDGF/PDGFRA/CRKL -0.006 0.051 -9999 0 -0.44 3 3
positive regulation of JUN kinase activity -0.004 0.036 -9999 0 -10000 0 0
CRKL 0.017 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 -0.006 0.051 -9999 0 -0.44 3 3
AP1 -0.18 0.37 -9999 0 -1 36 36
mol:IP3 -0.019 0.16 -9999 0 -0.54 18 18
PLCG1 -0.019 0.16 -9999 0 -0.54 18 18
PDGF/PDGFRA/alphaV Integrin -0.008 0.062 -9999 0 -0.47 4 4
RAPGEF1 0.017 0 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
mol:Ca2+ -0.019 0.16 -9999 0 -0.54 18 18
CAV3 0.017 0 -9999 0 -10000 0 0
CAV1 0.004 0.095 -9999 0 -0.7 4 4
SHC/Grb2/SOS1 -0.004 0.037 -9999 0 -10000 0 0
PDGF/PDGFRA/Shf -0.1 0.22 -9999 0 -0.55 41 41
FOS -0.13 0.39 -9999 0 -0.98 36 36
JUN -0.023 0.085 -9999 0 -0.57 5 5
oligodendrocyte development -0.008 0.062 -9999 0 -0.47 4 4
GRB2 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
mol:DAG -0.019 0.16 -9999 0 -0.54 18 18
PDGF/PDGFRA 0.004 0.075 -9999 0 -0.63 3 3
actin cytoskeleton reorganization -0.031 0.12 -9999 0 -0.53 13 13
SRF 0.033 0.01 -9999 0 -10000 0 0
SHC1 0.017 0 -9999 0 -10000 0 0
PI3K -0.005 0.042 -9999 0 -10000 0 0
PDGF/PDGFRA/Crk/C3G -0.007 0.049 -9999 0 -0.37 4 4
JAK1 0.022 0.055 -9999 0 -0.44 3 3
ELK1/SRF 0.013 0.13 -9999 0 -0.62 3 3
SHB -0.016 0.15 -9999 0 -0.72 10 10
SHF -0.11 0.28 -9999 0 -0.72 39 39
CSNK2A1 0.013 0.024 -9999 0 -10000 0 0
GO:0007205 -0.016 0.15 -9999 0 -0.51 18 18
SOS1 0.017 0 -9999 0 -10000 0 0
Ras protein signal transduction -0.004 0.036 -9999 0 -10000 0 0
PDGF/PDGFRA/SHB -0.031 0.12 -9999 0 -0.53 13 13
PDGF/PDGFRA/Caveolin-1 -0.015 0.086 -9999 0 -0.49 7 7
ITGAV 0.014 0.049 -9999 0 -0.72 1 1
ELK1 -0.014 0.16 -9999 0 -0.48 20 20
PIK3CA 0.017 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Crk -0.008 0.06 -9999 0 -0.45 4 4
JAK-STAT cascade 0.022 0.055 -9999 0 -0.44 3 3
cell proliferation -0.1 0.21 -9999 0 -0.55 41 41
Integrins in angiogenesis

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.05 0.16 -9999 0 -0.54 21 21
alphaV beta3 Integrin -0.018 0.082 -9999 0 -0.4 10 10
PTK2 0.05 0.12 -9999 0 -0.48 1 1
IGF1R 0.017 0 -9999 0 -10000 0 0
PI4KB 0.017 0 -9999 0 -10000 0 0
MFGE8 0.017 0 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
CDKN1B -0.008 0.035 -9999 0 -10000 0 0
VEGFA -0.052 0.22 -9999 0 -0.72 21 21
ILK -0.006 0.028 -9999 0 -10000 0 0
ROCK1 0.017 0 -9999 0 -10000 0 0
AKT1 -0.005 0.024 -9999 0 -10000 0 0
PTK2B 0.012 0.13 -9999 0 -10000 0 0
alphaV/beta3 Integrin/JAM-A -0.014 0.067 -9999 0 -10000 0 0
CBL 0.017 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.002 0.03 -9999 0 -0.46 1 1
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.2 0.19 -9999 0 -0.76 5 5
VEGF/Rho/ROCK/alphaV/beta3 Integrin 0.038 0.063 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Syndecan-1 -0.002 0.03 -9999 0 -0.46 1 1
PI4KA 0.017 0 -9999 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.21 0.2 -9999 0 -0.66 23 23
PI4 Kinase 0 0 -9999 0 -10000 0 0
PIK3CA 0.017 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Osteopontin -0.31 0.22 -9999 0 -0.46 151 151
RPS6KB1 -0.17 0.22 -9999 0 -0.61 24 24
TLN1 0.017 0 -9999 0 -10000 0 0
MAPK3 -0.077 0.13 -9999 0 -0.68 8 8
GPR124 0.01 0.07 -9999 0 -0.72 2 2
MAPK1 -0.076 0.13 -9999 0 -0.68 8 8
PXN 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Tumstatin -0.006 0.052 -9999 0 -0.46 3 3
cell adhesion -0.002 0.024 -9999 0 -10000 0 0
ANGPTL3 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Src -0.043 0.13 -9999 0 -0.46 21 21
IGF-1R heterotetramer 0.017 0 -9999 0 -10000 0 0
Rac1/GDP 0 0 -9999 0 -10000 0 0
TGFBR2 0.017 0 -9999 0 -10000 0 0
ITGB3 0.017 0 -9999 0 -10000 0 0
IGF1 -0.35 0.32 -9999 0 -0.63 126 126
RAC1 0.017 0 -9999 0 -10000 0 0
regulation of cell-matrix adhesion -0.006 0.052 -9999 0 -0.45 3 3
apoptosis 0.014 0.049 -9999 0 -0.72 1 1
CD47 0.017 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/CD47 -0.002 0.03 -9999 0 -0.46 1 1
VCL 0.017 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Del1 -0.043 0.12 -9999 0 -0.39 25 25
CSF1 0.017 0 -9999 0 -10000 0 0
PIK3C2A -0.016 0.065 -9999 0 -0.47 1 1
PI4 Kinase/Pyk2 -0.039 0.11 -9999 0 -0.59 2 2
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.04 0.12 -9999 0 -0.41 22 22
FAK1/Vinculin 0.055 0.1 -9999 0 -10000 0 0
alphaV beta3/Integrin/ppsTEM5 -0.006 0.052 -9999 0 -0.46 3 3
RHOA 0.017 0 -9999 0 -10000 0 0
VTN 0.017 0 -9999 0 -10000 0 0
BCAR1 0.017 0 -9999 0 -10000 0 0
FGF2 -0.01 0.13 -9999 0 -0.64 9 9
F11R 0.011 0.098 -9999 0 -0.47 9 9
alphaV/beta3 Integrin/Lactadherin -0.002 0.03 -9999 0 -0.46 1 1
alphaV/beta3 Integrin/TGFBR2 -0.002 0.03 -9999 0 -0.46 1 1
alphaV/beta3 Integrin/c-FMS/Cbl/Cas -0.002 0.027 -9999 0 -0.41 1 1
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
alphaV/beta3 Integrin/Talin -0.002 0.028 -9999 0 -0.42 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.069 0.24 -9999 0 -0.72 26 26
alphaV/beta3 Integrin/Pyk2 -0.037 0.11 -9999 0 -10000 0 0
SDC1 0.017 0 -9999 0 -10000 0 0
VAV3 -0.003 0.14 -9999 0 -0.71 1 1
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
IRS1 0.004 0.098 -9999 0 -0.72 4 4
FAK1/Paxillin 0.055 0.1 -9999 0 -10000 0 0
cell migration 0.065 0.096 -9999 0 -10000 0 0
ITGAV 0.014 0.049 -9999 0 -0.72 1 1
PI3K -0.012 0.057 -9999 0 -10000 0 0
SPP1 -0.48 0.35 -9999 0 -0.72 151 151
KDR 0.017 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.014 0.049 -9999 0 -0.72 1 1
COL4A3 0.01 0.07 -9999 0 -0.72 2 2
angiogenesis -0.033 0.15 -9999 0 -0.66 8 8
Rac1/GTP -0.044 0.11 -9999 0 -0.65 1 1
EDIL3 -0.053 0.2 -9999 0 -0.63 24 24
cell proliferation -0.002 0.03 -9999 0 -0.45 1 1
TCR signaling in naïve CD8+ T cells

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.042 0.13 -10000 0 -0.55 11 11
FYN -0.016 0.22 -10000 0 -0.71 14 14
LAT/GRAP2/SLP76 -0.043 0.14 -10000 0 -0.58 10 10
IKBKB 0.014 0.049 -10000 0 -0.72 1 1
AKT1 0.022 0.15 -10000 0 -0.48 12 12
B2M -0.011 0.14 -10000 0 -0.64 10 10
IKBKG -0.017 0.037 -10000 0 -0.18 1 1
MAP3K8 -0.089 0.26 -10000 0 -0.72 32 32
mol:Ca2+ -0.003 0.021 -10000 0 -0.14 4 4
integrin-mediated signaling pathway 0 0 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.006 0.21 -10000 0 -0.74 12 12
TRPV6 -0.01 0.098 -10000 0 -0.74 4 4
CD28 -0.061 0.21 -10000 0 -0.64 27 27
SHC1 0.008 0.2 -10000 0 -0.7 12 12
receptor internalization -0.007 0.21 -10000 0 -0.73 14 14
PRF1 0.013 0.18 -10000 0 -0.7 10 10
KRAS 0.017 0 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
COT/AKT1 -0.015 0.16 -10000 0 -0.38 19 19
LAT 0.005 0.2 -10000 0 -0.72 11 11
EntrezGene:6955 0.001 0.003 -10000 0 -10000 0 0
CD3D -0.011 0.14 -10000 0 -0.64 10 10
CD3E 0.017 0.006 -10000 0 -10000 0 0
CD3G -0.014 0.14 -10000 0 -0.65 11 11
RASGRP2 0.01 0.033 -10000 0 -0.19 4 4
RASGRP1 0.026 0.15 -10000 0 -0.46 12 12
HLA-A 0.003 0.097 -10000 0 -0.64 5 5
RASSF5 0.017 0 -10000 0 -10000 0 0
RAP1A/GTP/RAPL 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.036 0.055 -10000 0 -0.14 2 2
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.032 0.066 -10000 0 -0.25 6 6
PRKCA -0.038 0.083 -10000 0 -0.31 11 11
GRAP2 0.017 0 -10000 0 -10000 0 0
mol:IP3 -0.057 0.14 0.24 2 -0.48 13 15
EntrezGene:6957 0.001 0.004 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.001 0.19 -10000 0 -0.71 12 12
ORAI1 0.01 0.049 0.37 4 -10000 0 4
CSK -0.001 0.2 -10000 0 -0.74 11 11
B7 family/CD28 -0.095 0.23 -10000 0 -0.73 20 20
CHUK 0.017 0 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.012 0.23 -10000 0 -0.83 12 12
PTPN6 0.002 0.2 -10000 0 -0.73 12 12
VAV1 -0.016 0.24 -10000 0 -0.82 14 14
Monovalent TCR/CD3 -0.011 0.19 -10000 0 -0.65 15 15
CBL 0.017 0 -10000 0 -10000 0 0
LCK -0.013 0.22 -10000 0 -0.71 14 14
PAG1 -0.064 0.24 -10000 0 -0.64 20 20
RAP1A 0.017 0 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK -0.016 0.23 -10000 0 -0.85 12 12
CD80 0.004 0.098 -10000 0 -0.72 4 4
CD86 -0.015 0.14 -10000 0 -0.64 11 11
PDK1/CARD11/BCL10/MALT1 -0.04 0.08 -10000 0 -0.29 9 9
HRAS 0.017 0 -10000 0 -10000 0 0
GO:0035030 -0.015 0.21 -10000 0 -0.59 20 20
CD8A 0.001 0.004 -10000 0 -10000 0 0
CD8B 0.017 0.005 -10000 0 -10000 0 0
PTPRC -0.018 0.15 -10000 0 -0.64 12 12
PDK1/PKC theta 0.023 0.18 -10000 0 -0.61 12 12
CSK/PAG1 -0.055 0.23 -10000 0 -0.68 15 15
SOS1 0.017 0 -10000 0 -10000 0 0
peptide-MHC class I -0.012 0.14 -10000 0 -0.56 12 12
GRAP2/SLP76 -0.05 0.17 -10000 0 -0.69 11 11
STIM1 0.007 0.026 -10000 0 -10000 0 0
RAS family/GTP 0.044 0.07 -10000 0 -0.2 4 4
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.011 0.24 -10000 0 -0.8 14 14
mol:DAG -0.055 0.12 -10000 0 -0.42 14 14
RAP1A/GDP 0.018 0.024 -10000 0 -10000 0 0
PLCG1 -0.033 0.18 -10000 0 -0.72 15 15
CD247 -0.014 0.14 -10000 0 -0.64 11 11
cytotoxic T cell degranulation 0.015 0.18 -10000 0 -0.67 10 10
RAP1A/GTP -0.002 0.009 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.014 0.18 -10000 0 -0.59 12 12
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.073 0.17 0.3 1 -0.63 14 15
NRAS 0.007 0.085 -10000 0 -0.72 3 3
ZAP70 0.017 0.001 -10000 0 -10000 0 0
GRB2/SOS1 0 0 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 -0.059 0.16 -10000 0 -0.64 12 12
MALT1 0.017 0 -10000 0 -10000 0 0
TRAF6 0.017 0 -10000 0 -10000 0 0
CD8 heterodimer 0.012 0.009 -10000 0 -10000 0 0
CARD11 -0.046 0.21 -10000 0 -0.72 19 19
PRKCB -0.039 0.082 -10000 0 -0.29 14 14
PRKCE -0.038 0.079 -10000 0 -0.3 11 11
PRKCQ 0.009 0.2 -10000 0 -0.71 12 12
LCP2 0.004 0.095 -10000 0 -0.7 4 4
BCL10 0.017 0 -10000 0 -10000 0 0
regulation of survival gene product expression 0.025 0.13 -10000 0 -0.4 12 12
IKK complex 0.039 0.058 -10000 0 -0.13 1 1
RAS family/GDP -0.003 0.011 -10000 0 -0.086 2 2
MAP3K14 0.002 0.13 -10000 0 -0.3 13 13
PDPK1 0.027 0.14 -10000 0 -0.45 12 12
TCR/CD3/MHC I/CD8/Fyn -0.011 0.22 -10000 0 -0.77 13 13
Cellular roles of Anthrax toxin

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 -0.026 0.17 -10000 0 -0.72 13 13
ANTXR2 0.008 0.075 -10000 0 -0.63 3 3
negative regulation of myeloid dendritic cell antigen processing and presentation -0.006 0.022 -10000 0 -0.086 16 16
monocyte activation 0.01 0.066 -10000 0 -0.42 5 5
MAP2K2 -0.002 0.008 -10000 0 -10000 0 0
MAP2K1 -0.005 0.018 -10000 0 -10000 0 0
MAP2K7 -0.005 0.018 -10000 0 -10000 0 0
MAP2K6 -0.019 0.071 -10000 0 -0.36 9 9
CYAA -0.008 0.11 -10000 0 -0.39 16 16
MAP2K4 -0.011 0.049 -10000 0 -0.35 4 4
IL1B -0.063 0.17 -10000 0 -0.41 41 41
Channel -0.03 0.11 -10000 0 -0.42 16 16
NLRP1 -0.007 0.032 -10000 0 -0.41 1 1
CALM1 0.017 0 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.007 0.025 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.006 0.022 0.086 16 -10000 0 16
MAPK3 -0.008 0.037 -10000 0 -0.35 2 2
MAPK1 -0.006 0.029 -10000 0 -0.35 1 1
PGR -0.005 0.018 -10000 0 -10000 0 0
PA/Cellular Receptors -0.032 0.12 -10000 0 -0.45 16 16
apoptosis -0.006 0.022 -10000 0 -0.086 16 16
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) -0.007 0.1 -10000 0 -0.38 16 16
macrophage activation 0.017 0.045 -10000 0 -0.32 3 3
TNF 0.017 0 -10000 0 -10000 0 0
VCAM1 0.01 0.066 -10000 0 -0.42 5 5
platelet activation -0.007 0.025 -10000 0 -10000 0 0
MAPKKK cascade -0.011 0.031 0.16 1 -10000 0 1
IL18 -0.026 0.12 -10000 0 -0.34 25 25
negative regulation of macrophage activation -0.006 0.022 -10000 0 -0.086 16 16
LEF -0.006 0.022 -10000 0 -0.086 16 16
CASP1 -0.009 0.025 -10000 0 -0.2 1 1
mol:cAMP -0.007 0.026 -10000 0 -10000 0 0
necrosis -0.006 0.022 -10000 0 -0.086 16 16
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) -0.028 0.1 -10000 0 -0.39 16 16
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Signaling events mediated by PTP1B

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.017 0 -10000 0 -10000 0 0
Jak2/Leptin Receptor -0.05 0.066 -10000 0 -0.39 2 2
PTP1B/AKT1 -0.089 0.068 -10000 0 -0.34 1 1
FYN 0.014 0.043 -10000 0 -0.63 1 1
p210 bcr-abl/PTP1B -0.11 0.076 -10000 0 -0.33 2 2
EGFR -0.005 0.1 -10000 0 -0.66 5 5
EGF/EGFR -0.19 0.18 -10000 0 -0.47 61 61
CSF1 0.017 0 -10000 0 -10000 0 0
AKT1 0.017 0.002 -10000 0 -10000 0 0
INSR 0.008 0.075 -10000 0 -0.63 3 3
PTP1B/N-cadherin -0.11 0.093 -10000 0 -0.44 7 7
Insulin Receptor/Insulin -0.058 0.057 -10000 0 -0.45 2 2
HCK -0.044 0.19 -10000 0 -0.63 21 21
CRK 0.014 0.043 -10000 0 -0.63 1 1
TYK2 -0.096 0.073 -10000 0 -0.33 1 1
EGF -0.19 0.32 -10000 0 -0.68 65 65
YES1 0.017 0 -10000 0 -10000 0 0
CAV1 -0.1 0.1 -10000 0 -0.4 3 3
TXN 0.01 0.007 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 -0.09 0.09 -10000 0 -0.51 4 4
cell migration 0.11 0.076 0.33 2 -10000 0 2
STAT3 0.016 0.001 -10000 0 -10000 0 0
PRLR 0.01 0.097 -10000 0 -0.71 4 4
ITGA2B 0.015 0.001 -10000 0 -10000 0 0
CSF1R 0.017 0 -10000 0 -10000 0 0
Prolactin Receptor/Prolactin 0.027 0.083 -10000 0 -0.52 5 5
FGR 0.017 0 -10000 0 -10000 0 0
PTP1B/p130 Cas -0.096 0.072 -10000 0 -0.33 1 1
Crk/p130 Cas -0.084 0.075 -10000 0 -0.5 1 1
DOK1 -0.073 0.068 -10000 0 -0.38 1 1
JAK2 -0.048 0.061 -10000 0 -0.34 2 2
Jak2/Leptin Receptor/Leptin -0.07 0.12 -10000 0 -0.59 9 9
PIK3R1 0.017 0 -10000 0 -10000 0 0
PTPN1 -0.11 0.077 -10000 0 -0.33 2 2
LYN 0.017 0 -10000 0 -10000 0 0
CDH2 -0.005 0.12 -10000 0 -0.68 7 7
SRC -0.026 0.03 -10000 0 -10000 0 0
ITGB3 0.015 0.001 -10000 0 -10000 0 0
CAT1/PTP1B -0.12 0.12 -10000 0 -0.43 8 8
CAPN1 0.011 0.007 -10000 0 -10000 0 0
CSK 0.017 0 -10000 0 -10000 0 0
PI3K -0.037 0.052 -10000 0 -0.46 1 1
mol:H2O2 0.001 0.007 -10000 0 -10000 0 0
STAT3 (dimer) -0.063 0.12 -10000 0 -0.58 9 9
negative regulation of transcription -0.048 0.061 -10000 0 -0.33 2 2
FCGR2A -0.029 0.18 -10000 0 -0.72 14 14
FER -0.016 0.14 -10000 0 -0.72 8 8
alphaIIb/beta3 Integrin 0 0 -10000 0 -10000 0 0
BLK -0.17 0.29 -10000 0 -0.63 63 63
Insulin Receptor/Insulin/Shc -0.005 0.044 -10000 0 -0.38 3 3
RHOA 0.011 0.007 -10000 0 -10000 0 0
LEPR 0.005 0.086 -10000 0 -0.63 4 4
BCAR1 0.017 0 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.017 0 -10000 0 -10000 0 0
mol:NADPH -0.003 0.003 -10000 0 -10000 0 0
TRPV6 -0.058 0.16 -10000 0 -0.5 11 11
PRL 0.02 0.049 -10000 0 -0.72 1 1
SOCS3 0.007 0.12 -10000 0 -0.56 9 9
SPRY2 0.002 0.11 -10000 0 -0.71 5 5
Insulin Receptor/Insulin/IRS1 -0.013 0.075 -10000 0 -0.46 4 4
CSF1/CSF1R -0.083 0.07 -10000 0 -10000 0 0
Ras protein signal transduction 0.058 0.023 -10000 0 -10000 0 0
IRS1 0.004 0.098 -10000 0 -0.72 4 4
INS 0.017 0.002 -10000 0 -10000 0 0
LEP 0.011 0.061 -10000 0 -0.63 2 2
STAT5B -0.081 0.068 -10000 0 -0.28 3 3
STAT5A -0.081 0.068 -10000 0 -0.28 3 3
GRB2 0.017 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.096 0.072 -10000 0 -0.33 1 1
CSN2 0.062 0.03 -10000 0 -10000 0 0
PIK3CA 0.017 0 -10000 0 -10000 0 0
LAT -0.042 0.069 -10000 0 -0.34 1 1
YBX1 0.025 0.002 -10000 0 -10000 0 0
LCK 0.011 0.065 -10000 0 -0.68 2 2
SHC1 0.017 0 -10000 0 -10000 0 0
NOX4 -0.6 0.27 -10000 0 -0.72 187 187
RXR and RAR heterodimerization with other nuclear receptor

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.002 0.035 -9999 0 -10000 0 0
VDR 0 0.1 -9999 0 -0.63 6 6
FAM120B 0.017 0 -9999 0 -10000 0 0
RXRs/LXRs/DNA/9cRA 0.086 0.025 -9999 0 -10000 0 0
RXRs/LXRs/DNA/Oxysterols 0.097 0.037 -9999 0 -10000 0 0
MED1 0.007 0.085 -9999 0 -0.72 3 3
mol:9cRA 0.01 0.005 -9999 0 -10000 0 0
RARs/THRs/DNA/Src-1 0.028 0.079 -9999 0 -10000 0 0
RXRs/NUR77 0.061 0.044 -9999 0 -10000 0 0
RXRs/PPAR 0.054 0.053 -9999 0 -10000 0 0
NCOR2 0.017 0 -9999 0 -10000 0 0
VDR/VDR/Vit D3 -0.013 0.076 -9999 0 -0.47 6 6
RARs/VDR/DNA/Vit D3 -0.014 0.067 -9999 0 -0.39 3 3
RARA 0.014 0.049 -9999 0 -0.72 1 1
NCOA1 0.011 0.061 -9999 0 -0.63 2 2
VDR/VDR/DNA 0 0.1 -9999 0 -0.63 6 6
RARs/RARs/DNA/9cRA -0.005 0.045 -9999 0 -0.39 3 3
RARG 0.01 0.07 -9999 0 -0.72 2 2
RPS6KB1 -0.003 0.047 -9999 0 -0.69 1 1
RARs/THRs/DNA/SMRT 0.031 0.074 -9999 0 -10000 0 0
THRA 0.017 0 -9999 0 -10000 0 0
mol:Bile acids 0 0 -9999 0 -10000 0 0
VDR/Vit D3/DNA -0.013 0.076 -9999 0 -0.47 6 6
RXRs/PPAR/9cRA/PGJ2/DNA 0.062 0.013 -9999 0 -10000 0 0
NR1H4 -0.54 0.23 -9999 0 -0.63 192 192
RXRs/LXRs/DNA 0.092 0.017 -9999 0 -10000 0 0
NR1H2 0.026 0.003 -9999 0 -10000 0 0
NR1H3 0.027 0.004 -9999 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.051 0.06 -9999 0 -10000 0 0
NR4A1 0.01 0.07 -9999 0 -0.72 2 2
mol:ATRA 0 0 -9999 0 -10000 0 0
RXRs/FXR/9cRA/MED1 -0.2 0.11 -9999 0 -0.4 4 4
RXRG 0.026 0.003 -9999 0 -10000 0 0
RXR alpha/CCPG 0.032 0.003 -9999 0 -10000 0 0
RXRA 0.026 0.003 -9999 0 -10000 0 0
RXRB 0.027 0.004 -9999 0 -10000 0 0
THRB -0.018 0.15 -9999 0 -0.63 12 12
PPARG 0 0.1 -9999 0 -0.63 6 6
PPARD 0.017 0 -9999 0 -10000 0 0
TNF 0.1 0.034 -9999 0 -10000 0 0
mol:Oxysterols 0.01 0.005 -9999 0 -10000 0 0
cholesterol transport 0.097 0.036 -9999 0 -10000 0 0
PPARA 0.014 0.043 -9999 0 -0.63 1 1
mol:Vit D3 0 0 -9999 0 -10000 0 0
RARB 0.017 0 -9999 0 -10000 0 0
RXRs/NUR77/BCL2 -0.15 0.14 -9999 0 -10000 0 0
SREBF1 0.1 0.049 -9999 0 -10000 0 0
RXRs/RXRs/DNA/9cRA 0.062 0.014 -9999 0 -10000 0 0
ABCA1 0.099 0.083 -9999 0 -1.1 1 1
RARs/THRs -0.022 0.081 -9999 0 -10000 0 0
RXRs/FXR -0.27 0.14 -9999 0 -0.41 1 1
BCL2 -0.41 0.31 -9999 0 -0.63 147 147
IL27-mediated signaling events

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.028 0.016 -10000 0 -10000 0 0
CD4-positive alpha-beta T cell lineage commitment 0 0.001 -10000 0 -10000 0 0
cytokine production during immune response 0.024 0.12 0.86 1 -10000 0 1
IL27/IL27R/JAK1 -0.056 0.11 -10000 0 -0.82 1 1
TBX21 -0.16 0.27 -10000 0 -0.66 7 7
IL12B 0.008 0.07 -10000 0 -0.73 2 2
IL12A -0.005 0.1 -10000 0 -0.56 7 7
IL6ST 0.009 0.009 -10000 0 -10000 0 0
IL27RA/JAK1 0.003 0.053 -10000 0 -0.53 1 1
IL27 -0.04 0.18 -10000 0 -0.67 16 16
TYK2 0.014 0.008 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.094 0.14 -10000 0 -10000 0 0
T-helper 2 cell differentiation 0.024 0.12 0.86 1 -10000 0 1
T cell proliferation during immune response 0.024 0.12 0.86 1 -10000 0 1
MAPKKK cascade -0.024 0.12 -10000 0 -0.86 1 1
STAT3 0.017 0 -10000 0 -10000 0 0
STAT2 0.017 0 -10000 0 -10000 0 0
STAT1 -0.051 0.21 -10000 0 -0.72 20 20
IL12RB1 0.014 0.007 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.071 0.18 -10000 0 -0.64 4 4
IL27/IL27R/JAK2/TYK2 -0.024 0.12 -10000 0 -0.88 1 1
positive regulation of T cell mediated cytotoxicity -0.024 0.12 -10000 0 -0.86 1 1
STAT1 (dimer) -0.14 0.18 -10000 0 -0.9 3 3
JAK2 -0.001 0.1 -10000 0 -0.75 4 4
JAK1 0.015 0.003 -10000 0 -10000 0 0
STAT2 (dimer) -0.014 0.11 -10000 0 -0.83 1 1
T cell proliferation -0.2 0.24 -10000 0 -0.54 41 41
IL12/IL12R/TYK2/JAK2 -0.007 0.12 -10000 0 -0.56 1 1
IL17A -0.094 0.14 -10000 0 -10000 0 0
mast cell activation 0.024 0.12 0.86 1 -10000 0 1
IFNG -0.012 0.046 -10000 0 -0.094 49 49
T cell differentiation -0.007 0.007 -10000 0 -0.025 1 1
STAT3 (dimer) -0.014 0.11 -10000 0 -0.83 1 1
STAT5A (dimer) -0.014 0.11 -10000 0 -0.83 1 1
STAT4 (dimer) -0.015 0.11 -10000 0 -0.83 1 1
STAT4 0.014 0.043 -10000 0 -0.63 1 1
T cell activation -0.01 0.01 0.084 2 -10000 0 2
IL27R/JAK2/TYK2 -0.023 0.087 -10000 0 -0.92 1 1
GATA3 0.021 0.031 -10000 0 -10000 0 0
IL18 -0.04 0.16 -10000 0 -0.48 25 25
positive regulation of mast cell cytokine production -0.013 0.11 -10000 0 -0.8 1 1
IL27/EBI3 -0.035 0.13 -10000 0 -0.5 16 16
IL27RA -0.01 0.052 -10000 0 -0.55 2 2
IL6 -0.31 0.37 -10000 0 -0.71 104 104
STAT5A 0.017 0 -10000 0 -10000 0 0
monocyte differentiation -0.001 0.003 -10000 0 -10000 0 0
IL2 0.007 0.033 -10000 0 -10000 0 0
IL1B -0.089 0.22 -10000 0 -0.55 41 41
EBI3 0.009 0.009 -10000 0 -10000 0 0
TNF 0.015 0.002 -10000 0 -10000 0 0
VEGFR1 specific signals

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer 0.011 0.15 -9999 0 -0.62 11 11
VEGFR1 homodimer/NRP1 -0.031 0.14 -9999 0 -0.63 11 11
mol:DAG -0.022 0.21 -9999 0 -0.68 13 13
VEGFR1 homodimer/NRP1/VEGFR 121 -0.067 0.2 -9999 0 -0.53 28 28
CaM/Ca2+ -0.013 0.2 -9999 0 -0.88 6 6
HIF1A 0.006 0.12 -9999 0 -1 2 2
GAB1 0.011 0.061 -9999 0 -0.63 2 2
AKT1 0.04 0.15 -9999 0 -0.87 3 3
PLCG1 -0.023 0.21 -9999 0 -0.69 13 13
NOS3 0.034 0.16 -9999 0 -0.66 6 6
CBL 0.017 0 -9999 0 -10000 0 0
mol:NO 0.034 0.15 -9999 0 -0.63 6 6
FLT1 0.005 0.17 -9999 0 -0.71 11 11
PGF -0.013 0.14 -9999 0 -0.72 9 9
VEGFR1 homodimer/NRP2/VEGFR121 -0.067 0.2 -9999 0 -0.74 11 11
CALM1 0.017 0 -9999 0 -10000 0 0
PIK3CA 0.017 0 -9999 0 -10000 0 0
eNOS/Hsp90 0.041 0.15 -9999 0 -0.68 4 4
endothelial cell proliferation 0 0.18 -9999 0 -0.79 6 6
mol:Ca2+ -0.022 0.21 -9999 0 -0.67 13 13
MAPK3 -0.003 0.2 -9999 0 -0.79 7 7
MAPK1 -0.001 0.19 -9999 0 -0.8 6 6
PIK3R1 0.017 0 -9999 0 -10000 0 0
PLGF homodimer -0.013 0.14 -9999 0 -0.72 9 9
PRKACA 0.017 0 -9999 0 -10000 0 0
RP11-342D11.1 0 0 -9999 0 -10000 0 0
CAV1 0.004 0.095 -9999 0 -0.7 4 4
VEGFA homodimer -0.052 0.22 -9999 0 -0.72 21 21
VEGFR1 homodimer/VEGFA homodimer -0.034 0.22 -9999 0 -0.57 28 28
platelet activating factor biosynthetic process 0.006 0.19 -9999 0 -0.76 7 7
PI3K -0.041 0.15 -9999 0 -1 3 3
PRKCA -0.011 0.2 -9999 0 -0.85 6 6
PRKCB -0.02 0.2 -9999 0 -0.64 13 13
VEGFR1 homodimer/PLGF homodimer -0.008 0.19 -9999 0 -0.6 18 18
VEGFA -0.052 0.22 -9999 0 -0.72 21 21
VEGFB 0.017 0 -9999 0 -10000 0 0
mol:IP3 -0.022 0.21 -9999 0 -0.68 13 13
RASA1 0.021 0.14 -9999 0 -0.56 11 11
NRP2 0.014 0.049 -9999 0 -0.72 1 1
VEGFR1 homodimer 0.005 0.17 -9999 0 -0.71 11 11
VEGFB homodimer 0.017 0 -9999 0 -10000 0 0
NCK1 0.017 0 -9999 0 -10000 0 0
eNOS/Caveolin-1 0.036 0.15 -9999 0 -0.68 4 4
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
mol:PI-3-4-5-P3 -0.04 0.15 -9999 0 -0.97 3 3
mol:L-citrulline 0.034 0.15 -9999 0 -0.63 6 6
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP -0.061 0.18 -9999 0 -0.94 5 5
VEGFR1 homodimer/VEGFA homodimer/NCK1 -0.065 0.19 -9999 0 -0.71 11 11
CD2AP 0.017 0 -9999 0 -10000 0 0
PI3K/GAB1 -0.04 0.15 -9999 0 -1 3 3
PDPK1 0.026 0.16 -9999 0 -0.91 3 3
VEGFR1 homodimer/VEGFA homodimer/SHP2 -0.067 0.19 -9999 0 -0.71 11 11
mol:NADP 0.034 0.15 -9999 0 -0.63 6 6
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
ubiquitin-dependent protein catabolic process -0.06 0.18 -9999 0 -0.92 5 5
VEGFR1 homodimer/NRP2 0.009 0.16 -9999 0 -0.65 11 11
Regulation of Androgen receptor activity

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.032 0 -9999 0 -10000 0 0
SMARCC1 0.002 0.085 -9999 0 -10000 0 0
REL 0.016 0.001 -9999 0 -10000 0 0
HDAC7 -0.034 0.15 -9999 0 -0.49 10 10
JUN 0.001 0.11 -9999 0 -0.72 5 5
EP300 0.017 0 -9999 0 -10000 0 0
KAT2B 0 0 -9999 0 -10000 0 0
KAT5 0 0 -9999 0 -10000 0 0
MAPK14 0 0.1 -9999 0 -0.49 9 9
FOXO1 -0.012 0.13 -9999 0 -0.63 10 10
T-DHT/AR -0.032 0.16 -9999 0 -0.51 10 10
MAP2K6 -0.016 0.13 -9999 0 -0.65 9 9
BRM/BAF57 -0.005 0.05 -9999 0 -0.54 2 2
MAP2K4 -0.001 0.086 -9999 0 -0.63 4 4
SMARCA2 0.018 0.001 -9999 0 -10000 0 0
PDE9A -0.56 0.57 -9999 0 -1.1 112 112
NCOA2 0.018 0 -9999 0 -10000 0 0
CEBPA 0.017 0 -9999 0 -10000 0 0
EHMT2 0.018 0.001 -9999 0 -10000 0 0
cell proliferation 0.015 0.15 -9999 0 -0.47 1 1
NR0B1 0 0.11 -9999 0 -0.72 5 5
EGR1 -0.016 0.15 -9999 0 -0.66 11 11
RXRs/9cRA 0 0 -9999 0 -10000 0 0
AR/RACK1/Src 0.031 0.1 -9999 0 -10000 0 0
AR/GR -0.015 0.13 -9999 0 -0.38 11 11
GNB2L1 0.017 0 -9999 0 -10000 0 0
PKN1 0.017 0 -9999 0 -10000 0 0
RCHY1 0.017 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity 0.001 0 -9999 0 -10000 0 0
MAPK8 0.011 0.067 -9999 0 -0.46 4 4
T-DHT/AR/TIF2/CARM1 0.029 0.1 -9999 0 -10000 0 0
SRC 0.016 0.097 -9999 0 -10000 0 0
NR3C1 -0.053 0.2 -9999 0 -0.63 24 24
KLK3 -0.14 0.12 -9999 0 -0.62 2 2
APPBP2 0.01 0.01 -9999 0 -10000 0 0
TRIM24 0.018 0.001 -9999 0 -10000 0 0
T-DHT/AR/TIP60 -0.034 0.088 -9999 0 -0.41 9 9
TMPRSS2 -0.063 0.11 -9999 0 -1.4 1 1
RXRG 0.017 0 -9999 0 -10000 0 0
mol:9cRA 0 0 -9999 0 -0.006 1 1
RXRA 0.017 0 -9999 0 -10000 0 0
RXRB 0.017 0 -9999 0 -10000 0 0
CARM1 0.018 0 -9999 0 -10000 0 0
NR2C2 0.017 0 -9999 0 -10000 0 0
KLK2 0.04 0.091 -9999 0 -10000 0 0
AR 0.02 0.069 -9999 0 -10000 0 0
SENP1 0.017 0 -9999 0 -10000 0 0
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
MDM2 0.015 0.001 -9999 0 -10000 0 0
SRY 0.012 0.049 -9999 0 -0.72 1 1
GATA2 0.017 0 -9999 0 -10000 0 0
MYST2 0.017 0 -9999 0 -10000 0 0
HOXB13 -0.59 0.28 -9999 0 -0.72 185 185
T-DHT/AR/RACK1/Src 0.024 0.1 -9999 0 -10000 0 0
positive regulation of transcription 0.017 0 -9999 0 -10000 0 0
DNAJA1 0.007 0.051 -9999 0 -0.75 1 1
proteasomal ubiquitin-dependent protein catabolic process 0.04 0 -9999 0 -10000 0 0
NCOA1 0.016 0.066 -9999 0 -0.66 2 2
SPDEF -0.19 0.3 -9999 0 -0.63 72 72
T-DHT/AR/TIF2 0.041 0.062 -9999 0 -10000 0 0
T-DHT/AR/Hsp90 0.007 0.11 -9999 0 -0.44 1 1
GSK3B 0.012 0.049 -9999 0 -0.72 1 1
NR2C1 0.003 0.098 -9999 0 -0.72 4 4
mol:T-DHT 0.003 0.1 -9999 0 -0.4 9 9
SIRT1 0.017 0 -9999 0 -10000 0 0
ZMIZ2 0.015 0.001 -9999 0 -10000 0 0
POU2F1 0.019 0.019 -9999 0 -10000 0 0
T-DHT/AR/DAX-1 -0.001 0.12 -9999 0 -0.44 1 1
CREBBP 0.017 0 -9999 0 -10000 0 0
SMARCE1 0.011 0.07 -9999 0 -0.72 2 2
Ras signaling in the CD4+ TCR pathway

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.014 0.16 -9999 0 -0.48 6 6
MAP3K8 -0.09 0.26 -9999 0 -0.72 32 32
FOS 0.004 0.1 -9999 0 -0.42 2 2
PRKCA 0.013 0.051 -9999 0 -0.74 1 1
PTPN7 -0.009 0.14 -9999 0 -0.72 8 8
HRAS 0.017 0.001 -9999 0 -10000 0 0
PRKCB -0.001 0.007 -9999 0 -0.019 33 33
NRAS 0.007 0.085 -9999 0 -0.72 3 3
RAS family/GTP -0.006 0.049 -9999 0 -0.42 3 3
MAPK3 0.009 0.074 -9999 0 -0.42 2 2
MAP2K1 0.011 0.076 -9999 0 -0.51 1 1
ELK1 0.002 0.099 -9999 0 -0.73 4 4
BRAF -0.005 0.025 -9999 0 -0.33 1 1
mol:GTP -0.001 0.002 -9999 0 -0.006 33 33
MAPK1 0.01 0.076 -9999 0 -0.63 1 1
RAF1 -0.005 0.025 -9999 0 -0.33 1 1
KRAS 0.017 0.001 -9999 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.014 0.043 -9999 0 -0.63 1 1
SPHK1 -0.072 0.24 -9999 0 -0.72 27 27
GNAI2 0.017 0 -9999 0 -10000 0 0
mol:S1P -0.031 0.12 -9999 0 -0.56 2 2
GNAO1 0.017 0 -9999 0 -10000 0 0
mol:Sphinganine-1-P -0.039 0.19 -9999 0 -0.55 27 27
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 -0.036 0.073 -9999 0 -0.42 2 2
GNAI3 0.017 0 -9999 0 -10000 0 0
G12/G13 0 0 -9999 0 -10000 0 0
S1PR3 0 0 -9999 0 -10000 0 0
S1PR2 0 0 -9999 0 -10000 0 0
EDG1 -0.021 0.15 -9999 0 -0.63 13 13
S1P1/S1P -0.041 0.14 -9999 0 -0.43 15 15
S1PR5 0 0 -9999 0 -10000 0 0
S1PR4 0 0 -9999 0 -10000 0 0
GNAI1 -0.07 0.22 -9999 0 -0.63 30 30
S1P/S1P5/G12 -0.041 0.082 -9999 0 -0.45 2 2
S1P/S1P3/Gq -0.019 0.12 -9999 0 -0.54 4 4
S1P/S1P4/Gi -0.008 0.099 -9999 0 -0.35 5 5
GNAQ 0 0 -9999 0 -10000 0 0
GNAZ 0.017 0 -9999 0 -10000 0 0
GNA14 -0.009 0.13 -9999 0 -0.63 9 9
GNA15 -0.006 0.13 -9999 0 -0.72 7 7
GNA12 0.017 0 -9999 0 -10000 0 0
GNA13 0.017 0 -9999 0 -10000 0 0
GNA11 0 0.1 -9999 0 -0.63 6 6
ABCC1 -0.059 0.22 -9999 0 -0.72 23 23
Signaling events mediated by HDAC Class III

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.017 0 -10000 0 -10000 0 0
HDAC4 0.017 0 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle -0.002 0.015 -10000 0 -10000 0 0
CDKN1A -0.007 0.096 -10000 0 -0.82 3 3
KAT2B 0 0 -10000 0 -10000 0 0
BAX 0.014 0.049 -10000 0 -0.72 1 1
FOXO3 0 0 -10000 0 -10000 0 0
FOXO1 -0.012 0.13 -10000 0 -0.63 10 10
FOXO4 0.031 0 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.017 0 -10000 0 -10000 0 0
TAT 0.017 0 -10000 0 -10000 0 0
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 0.008 0.065 -10000 0 -0.55 3 3
PPARGC1A -0.28 0.32 -10000 0 -0.63 101 101
FHL2 0.014 0.049 -10000 0 -0.72 1 1
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.002 0.018 -10000 0 -10000 0 0
HIST2H4A 0.002 0.015 -10000 0 -10000 0 0
SIRT1/FOXO3a 0.002 0.016 -10000 0 -10000 0 0
SIRT1 0.003 0.024 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.002 0.018 -10000 0 -10000 0 0
SIRT1/Histone H1b 0.001 0.027 -10000 0 -10000 0 0
apoptosis 0 0.035 0.46 1 -10000 0 1
SIRT1/PGC1A -0.18 0.2 -10000 0 -0.4 101 101
p53/SIRT1 -0.016 0.12 0.42 3 -0.55 9 12
SIRT1/FOXO4 0.002 0.02 -10000 0 -10000 0 0
FOXO1/FHL2/SIRT1 -0.016 0.087 -10000 0 -0.39 10 10
HIST1H1E 0.029 0.026 -10000 0 -10000 0 0
SIRT1/p300 0.002 0.018 -10000 0 -10000 0 0
muscle cell differentiation 0.004 0.057 0.47 3 -10000 0 3
TP53 -0.026 0.14 -10000 0 -0.73 9 9
KU70/SIRT1/BAX 0 0.035 -10000 0 -0.46 1 1
CREBBP 0.017 0 -10000 0 -10000 0 0
MEF2D 0.017 0 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 0.002 0.018 -10000 0 -10000 0 0
ACSS2 0.027 0.036 -10000 0 -0.46 1 1
SIRT1/PCAF/MYOD -0.004 0.057 -10000 0 -0.47 3 3
Signaling mediated by p38-alpha and p38-beta

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.13 0.28 -9999 0 -0.56 66 66
MKNK1 0.017 0 -9999 0 -10000 0 0
MAPK14 -0.034 0.1 -9999 0 -10000 0 0
ATF2/c-Jun -0.008 0.13 -9999 0 -0.7 5 5
MAPK11 -0.037 0.11 -9999 0 -0.68 1 1
MITF -0.022 0.12 -9999 0 -10000 0 0
MAPKAPK5 -0.022 0.12 -9999 0 -10000 0 0
KRT8 -0.029 0.12 -9999 0 -10000 0 0
MAPKAPK3 0.017 0 -9999 0 -10000 0 0
MAPKAPK2 0.017 0 -9999 0 -10000 0 0
p38alpha-beta/CK2 -0.051 0.15 -9999 0 -0.44 3 3
CEBPB -0.032 0.13 -9999 0 -0.55 2 2
SLC9A1 -0.022 0.12 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
ATF2 -0.019 0.12 -9999 0 -0.42 2 2
p38alpha-beta/MNK1 -0.059 0.091 -9999 0 -10000 0 0
JUN -0.007 0.13 -9999 0 -0.7 5 5
PPARGC1A -0.21 0.25 -9999 0 -0.44 101 101
USF1 -0.046 0.16 -9999 0 -0.55 10 10
RAB5/GDP/GDI1 -0.038 0.059 -9999 0 -10000 0 0
NOS2 -0.035 0.12 -9999 0 -0.32 2 2
DDIT3 -0.029 0.12 -9999 0 -0.55 1 1
RAB5A 0.017 0 -9999 0 -10000 0 0
HSPB1 -0.008 0.1 -9999 0 -0.46 2 2
p38alpha-beta/HBP1 -0.059 0.091 -9999 0 -10000 0 0
CREB1 -0.021 0.12 -9999 0 -0.41 3 3
RAB5/GDP 0 0 -9999 0 -10000 0 0
EIF4E -0.007 0.1 -9999 0 -10000 0 0
RPS6KA4 -0.022 0.12 -9999 0 -10000 0 0
PLA2G4A -0.12 0.21 -9999 0 -0.54 24 24
GDI1 -0.022 0.12 -9999 0 -10000 0 0
TP53 -0.045 0.15 -9999 0 -0.47 4 4
RPS6KA5 -0.034 0.14 -9999 0 -0.48 6 6
ESR1 -0.033 0.13 -9999 0 -0.38 6 6
HBP1 0.017 0 -9999 0 -10000 0 0
MEF2C -0.084 0.18 -9999 0 -0.39 36 36
MEF2A -0.022 0.12 -9999 0 -10000 0 0
EIF4EBP1 -0.025 0.12 -9999 0 -0.41 3 3
KRT19 -0.035 0.14 -9999 0 -0.46 7 7
ELK4 -0.03 0.14 -9999 0 -0.55 4 4
ATF6 -0.022 0.12 -9999 0 -10000 0 0
ATF1 -0.021 0.12 -9999 0 -0.41 3 3
p38alpha-beta/MAPKAPK2 -0.059 0.091 -9999 0 -0.39 1 1
p38alpha-beta/MAPKAPK3 -0.059 0.091 -9999 0 -0.39 1 1
TCGA08_rtk_signaling

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.008 0.075 -10000 0 -0.63 3 3
HRAS 0.017 0 -10000 0 -10000 0 0
EGFR 0.002 0.099 -10000 0 -0.65 5 5
AKT 0.033 0.038 -10000 0 -10000 0 0
FOXO3 0.017 0 -10000 0 -10000 0 0
AKT1 0.017 0 -10000 0 -10000 0 0
FOXO1 -0.012 0.13 -10000 0 -0.63 10 10
AKT3 0.017 0 -10000 0 -10000 0 0
FOXO4 0.017 0 -10000 0 -10000 0 0
MET -0.32 0.37 -10000 0 -0.72 101 101
PIK3CA 0.017 0 -10000 0 -10000 0 0
PIK3CB 0.014 0.049 -10000 0 -0.72 1 1
NRAS 0.007 0.085 -10000 0 -0.72 3 3
PIK3CG 0 0.1 -10000 0 -0.63 6 6
PIK3R3 0.017 0 -10000 0 -10000 0 0
PIK3R2 0.017 0 -10000 0 -10000 0 0
NF1 0.017 0 -10000 0 -10000 0 0
RAS -0.044 0.084 -10000 0 -0.31 4 4
ERBB2 -0.006 0.13 -10000 0 -0.71 7 7
proliferation/survival/translation -0.012 0.055 -10000 0 -10000 0 0
PI3K 0.015 0.067 0.22 4 -0.24 7 11
PIK3R1 0.017 0 -10000 0 -10000 0 0
KRAS 0.017 0 -10000 0 -10000 0 0
FOXO 0.036 0.042 -10000 0 -10000 0 0
AKT2 0.017 0 -10000 0 -10000 0 0
PTEN 0 0.1 -10000 0 -0.63 6 6
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A 0.017 0 -9999 0 -10000 0 0
oxygen homeostasis 0 0 -9999 0 -10000 0 0
TCEB2 0.017 0 -9999 0 -10000 0 0
TCEB1 0.01 0.07 -9999 0 -0.72 2 2
HIF1A/p53 -0.015 0.1 -9999 0 -0.45 3 3
HIF1A -0.01 0.073 -9999 0 -10000 0 0
COPS5 0.017 0 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2 -0.005 0.043 -9999 0 -10000 0 0
FIH (dimer) 0.017 0 -9999 0 -10000 0 0
CDKN2A -0.21 0.34 -9999 0 -0.72 70 70
ARNT/IPAS 0 0 -9999 0 -10000 0 0
HIF1AN 0.017 0 -9999 0 -10000 0 0
GNB2L1 0.017 0 -9999 0 -10000 0 0
HIF1A/ARNT 0 0.07 -9999 0 -10000 0 0
CUL2 0.017 0 -9999 0 -10000 0 0
OS9 0.017 0 -9999 0 -10000 0 0
RACK1/Elongin B/Elongin C -0.004 0.043 -9999 0 -0.46 2 2
response to hypoxia 0 0 -9999 0 -10000 0 0
HIF1A/Hsp90 -0.001 0.073 -9999 0 -10000 0 0
PHD1-3/OS9 -0.13 0.16 -9999 0 -10000 0 0
HIF1A/RACK1/Elongin B/Elongin C -0.024 0.051 -9999 0 -0.41 1 1
VHL 0.014 0.049 -9999 0 -0.72 1 1
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
HIF1A/JAB1 0 0.07 -9999 0 -10000 0 0
EGLN3 -0.23 0.32 -9999 0 -0.63 86 86
EGLN2 0.017 0 -9999 0 -10000 0 0
EGLN1 0.017 0 -9999 0 -10000 0 0
TP53 -0.013 0.14 -9999 0 -0.72 9 9
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.038 0.03 -9999 0 -10000 0 0
ARNT 0.017 0 -9999 0 -10000 0 0
ARD1A -0.006 0.13 -9999 0 -0.72 7 7
RBX1 0.017 0 -9999 0 -10000 0 0
HIF1A/p19ARF -0.12 0.19 -9999 0 -0.47 24 24
E-cadherin signaling events

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin -0.022 0.095 -9999 0 -0.46 6 6
E-cadherin/beta catenin -0.027 0.11 -9999 0 -0.5 12 12
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
JUP 0.017 0 -9999 0 -10000 0 0
CDH1 0 0.1 -9999 0 -0.63 6 6
Canonical NF-kappaB pathway

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.022 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.062 0.078 -9999 0 -10000 0 0
ERC1 0.017 0 -9999 0 -10000 0 0
RIP2/NOD2 -0.22 0.3 -9999 0 -0.59 81 81
NFKBIA 0.064 0 -9999 0 -10000 0 0
BIRC2 0.017 0 -9999 0 -10000 0 0
IKBKB 0.014 0.049 -9999 0 -0.72 1 1
RIPK2 -0.12 0.29 -9999 0 -0.72 43 43
IKBKG -0.057 0.08 -9999 0 -10000 0 0
IKK complex/A20 -0.043 0.069 -9999 0 -0.58 1 1
NEMO/A20/RIP2 -0.12 0.29 -9999 0 -0.72 43 43
XPO1 0.017 0 -9999 0 -10000 0 0
NEMO/ATM -0.007 0.1 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
RAN 0.014 0.049 -9999 0 -0.72 1 1
Exportin 1/RanGTP -0.002 0.031 -9999 0 -0.47 1 1
IKK complex/ELKS -0.042 0.067 -9999 0 -0.56 1 1
BCL10/MALT1/TRAF6 0 0 -9999 0 -10000 0 0
NOD2 -0.14 0.3 -9999 0 -0.72 48 48
NFKB1 0.022 0 -9999 0 -10000 0 0
RELA 0.022 0 -9999 0 -10000 0 0
MALT1 0.017 0 -9999 0 -10000 0 0
cIAP1/UbcH5C 0 0 -9999 0 -10000 0 0
ATM 0.017 0 -9999 0 -10000 0 0
TNF/TNFR1A 0 0 -9999 0 -10000 0 0
TRAF6 0.017 0 -9999 0 -10000 0 0
PRKCA 0.014 0.049 -9999 0 -0.72 1 1
CHUK 0.017 0 -9999 0 -10000 0 0
UBE2D3 0.017 0 -9999 0 -10000 0 0
TNF 0.017 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0 0 -9999 0 -10000 0 0
BCL10 0.017 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.064 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.022 0 -9999 0 -10000 0 0
TNFRSF1A 0.017 0 -9999 0 -10000 0 0
IKK complex -0.048 0.075 -9999 0 -0.61 1 1
CYLD 0.017 0 -9999 0 -10000 0 0
IKK complex/PKC alpha -0.045 0.074 -9999 0 -0.53 2 2
ErbB4 signaling events

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF 0.041 0.058 -10000 0 -0.42 3 3
epithelial cell differentiation -0.016 0.058 -10000 0 -10000 0 0
ITCH 0.018 0.006 -10000 0 -10000 0 0
WWP1 0.049 0.021 -10000 0 -10000 0 0
FYN 0.014 0.043 -10000 0 -0.63 1 1
EGFR 0.002 0.099 -10000 0 -0.65 5 5
PRL 0.014 0.049 -10000 0 -0.72 1 1
neuron projection morphogenesis 0.089 0.04 -10000 0 -10000 0 0
PTPRZ1 -0.056 0.21 -10000 0 -0.64 25 25
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0 0.002 -10000 0 -10000 0 0
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta 0.052 0.018 -10000 0 -10000 0 0
ADAM17 0.018 0.006 -10000 0 -10000 0 0
ErbB4/ErbB4 0.049 0.026 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.045 0.034 -10000 0 -10000 0 0
NCOR1 0.014 0.043 -10000 0 -0.63 1 1
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.002 0.021 -10000 0 -10000 0 0
GRIN2B 0.007 0.15 -10000 0 -0.44 3 3
ErbB4/ErbB2/betacellulin -0.019 0.078 -10000 0 -0.46 1 1
STAT1 -0.049 0.21 -10000 0 -0.72 20 20
HBEGF 0.007 0.085 -10000 0 -0.72 3 3
PRLR 0.004 0.098 -10000 0 -0.72 4 4
E4ICDs/ETO2 -0.1 0.19 -10000 0 -0.44 2 2
axon guidance 0.056 0.067 -10000 0 -10000 0 0
NEDD4 -0.003 0.12 -10000 0 -0.72 6 6
Prolactin receptor/Prolactin receptor/Prolactin -0.012 0.08 -10000 0 -0.54 5 5
CBFA2T3 -0.22 0.31 -10000 0 -0.63 83 83
ErbB4/ErbB2/HBEGF -0.018 0.077 -10000 0 -0.46 1 1
MAPK3 0.08 0.034 -10000 0 -10000 0 0
STAT1 (dimer) 0.005 0.14 -10000 0 -0.42 20 20
MAPK1 0.082 0.026 -10000 0 -10000 0 0
JAK2 0.004 0.098 -10000 0 -0.72 4 4
ErbB4/ErbB2/neuregulin 1 beta -0.013 0.066 -10000 0 -0.46 1 1
NRG1 0.032 0.003 -10000 0 -10000 0 0
NRG3 0.014 0.043 -10000 0 -0.63 1 1
NRG2 0.002 0.096 -10000 0 -0.63 5 5
NRG4 -0.01 0.13 -10000 0 -0.66 9 9
heart development 0.056 0.067 -10000 0 -10000 0 0
neural crest cell migration -0.012 0.065 -10000 0 -0.46 1 1
ERBB2 0.015 0.099 -10000 0 -0.53 7 7
WWOX/E4ICDs 0.047 0.021 -10000 0 -10000 0 0
SHC1 0.017 0 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 -0.023 0.083 -10000 0 -10000 0 0
apoptosis 0.044 0.052 0.62 1 -10000 0 1
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.038 0.062 -10000 0 -10000 0 0
ErbB4/ErbB2/epiregulin -0.27 0.19 -10000 0 -0.65 10 10
ErbB4/ErbB4/betacellulin/betacellulin 0.038 0.062 -10000 0 -10000 0 0
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.019 0.075 -10000 0 -10000 0 0
MDM2 0.054 0.022 -10000 0 -10000 0 0
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.001 0.004 -10000 0 -10000 0 0
STAT5A 0.063 0.062 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 1 beta -0.008 0.047 -10000 0 -10000 0 0
DLG4 0.017 0 -10000 0 -10000 0 0
GRB2/SHC 0 0 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 -0.003 0.023 -10000 0 -10000 0 0
STAT5A (dimer) -0.016 0.061 -10000 0 -10000 0 0
MAP3K7IP2 0.017 0 -10000 0 -10000 0 0
STAT5B (dimer) 0.059 0.059 -10000 0 -10000 0 0
LRIG1 -0.009 0.13 -10000 0 -0.63 9 9
EREG -0.49 0.34 -10000 0 -0.72 155 155
BTC 0.002 0.096 -10000 0 -0.63 5 5
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.056 0.068 -10000 0 -10000 0 0
ERBB4 0.049 0.026 -10000 0 -10000 0 0
STAT5B 0.017 0 -10000 0 -10000 0 0
YAP1 -0.003 0.026 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 -0.026 0.091 -10000 0 -0.46 1 1
glial cell differentiation 0.003 0.023 -10000 0 -10000 0 0
WWOX 0.017 0 -10000 0 -10000 0 0
cell proliferation 0.054 0.089 -10000 0 -10000 0 0
BARD1 signaling events

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0 0 -10000 0 -10000 0 0
ATM 0.017 0 -10000 0 -10000 0 0
UBE2D3 0.017 0 -10000 0 -10000 0 0
PRKDC -0.046 0.21 -10000 0 -0.72 19 19
ATR 0.014 0.049 -10000 0 -0.72 1 1
UBE2L3 0.017 0 -10000 0 -10000 0 0
FANCD2 0.032 0.032 -10000 0 -10000 0 0
protein ubiquitination -0.073 0.17 -10000 0 -0.76 6 6
XRCC5 0.017 0 -10000 0 -10000 0 0
XRCC6 0.017 0 -10000 0 -10000 0 0
M/R/N Complex 0 0 -10000 0 -10000 0 0
MRE11A 0.017 0 -10000 0 -10000 0 0
DNA-PK -0.039 0.13 -10000 0 -0.46 19 19
FA complex/FANCD2/Ubiquitin -0.044 0.099 -10000 0 -0.47 7 7
FANCF 0.011 0.061 -10000 0 -0.63 2 2
BRCA1 0.004 0.098 -10000 0 -0.72 4 4
CCNE1 -0.033 0.18 -10000 0 -0.72 15 15
CDK2/Cyclin E1 -0.095 0.22 -10000 0 -0.59 36 36
FANCG -0.016 0.15 -10000 0 -0.72 10 10
BRCA1/BACH1/BARD1 -0.01 0.071 -10000 0 -0.54 4 4
FANCE 0.014 0.049 -10000 0 -0.72 1 1
FANCC 0.017 0 -10000 0 -10000 0 0
NBN 0.017 0 -10000 0 -10000 0 0
FANCA -0.16 0.31 -10000 0 -0.72 52 52
DNA repair 0.012 0.15 -10000 0 -0.6 4 4
BRCA1/BARD1/ubiquitin -0.01 0.071 -10000 0 -0.54 4 4
BARD1/DNA-PK -0.035 0.11 -10000 0 -0.41 19 19
FANCL 0.017 0 -10000 0 -10000 0 0
mRNA polyadenylation 0 0 -10000 0 -10000 0 0
BRCA1/BARD1/CTIP/M/R/N Complex 0.052 0.022 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1/TopBP1 -0.008 0.06 -10000 0 -0.46 4 4
BRCA1/BARD1/P53 -0.026 0.11 -10000 0 -0.44 13 13
BARD1/CSTF1/BRCA1 -0.008 0.06 -10000 0 -0.46 4 4
BRCA1/BACH1 0.004 0.098 -10000 0 -0.72 4 4
BARD1 0.017 0 -10000 0 -10000 0 0
PCNA -0.013 0.14 -10000 0 -0.72 9 9
BRCA1/BARD1/UbcH5C -0.008 0.06 -10000 0 -0.46 4 4
BRCA1/BARD1/UbcH7 -0.008 0.06 -10000 0 -0.46 4 4
BRCA1/BARD1/RAD51/PCNA -0.024 0.11 -10000 0 -0.48 11 11
BARD1/DNA-PK/P53 -0.047 0.14 -10000 0 -0.78 2 2
BRCA1/BARD1/Ubiquitin -0.01 0.071 -10000 0 -0.54 4 4
BRCA1/BARD1/CTIP -0.007 0.054 -10000 0 -0.41 4 4
FA complex -0.019 0.13 -10000 0 -0.42 9 9
BARD1/EWS -0.002 0.036 -10000 0 -0.54 1 1
RBBP8 0.031 0 -10000 0 -10000 0 0
TP53 -0.013 0.14 -10000 0 -0.72 9 9
TOPBP1 0.017 0 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle 0.025 0.1 0.44 13 -10000 0 13
BRCA1/BARD1 -0.074 0.18 -10000 0 -0.77 6 6
CSTF1 0.017 0 -10000 0 -10000 0 0
BARD1/EWS-Fli1 0 0 -10000 0 -10000 0 0
CDK2 -0.066 0.23 -10000 0 -0.72 25 25
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.017 0 -10000 0 -10000 0 0
RAD50 0.017 0 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme -0.01 0.071 -10000 0 -0.54 4 4
EWSR1 0.014 0.049 -10000 0 -0.72 1 1
a4b1 and a4b7 Integrin signaling

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
ITGB7 -0.009 0.13 -9999 0 -0.63 9 9
ITGA4 0.011 0.061 -9999 0 -0.63 2 2
alpha4/beta7 Integrin -0.023 0.099 -9999 0 -0.46 11 11
alpha4/beta1 Integrin -0.007 0.056 -9999 0 -0.49 3 3
Nongenotropic Androgen signaling

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.013 0.038 -10000 0 -0.55 1 1
GNB1/GNG2 -0.002 0.028 -10000 0 -0.42 1 1
regulation of S phase of mitotic cell cycle 0.04 0.018 -10000 0 -10000 0 0
GNAO1 0.017 0 -10000 0 -10000 0 0
HRAS 0.017 0.002 -10000 0 -10000 0 0
SHBG/T-DHT 0 0 -10000 0 -10000 0 0
PELP1 0.017 0.002 -10000 0 -10000 0 0
AKT1 0.016 0.001 -10000 0 -10000 0 0
MAP2K1 0.048 0.053 -10000 0 -10000 0 0
T-DHT/AR -0.001 0.037 -10000 0 -0.55 1 1
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP -0.001 0.003 -10000 0 -0.008 33 33
GNAI2 0.017 0 -10000 0 -10000 0 0
GNAI3 0.017 0 -10000 0 -10000 0 0
GNAI1 -0.07 0.22 -10000 0 -0.63 30 30
mol:GDP -0.002 0.023 -10000 0 -0.34 1 1
cell proliferation 0.03 0.16 -10000 0 -10000 0 0
PIK3CA 0.017 0 -10000 0 -10000 0 0
FOS -0.048 0.32 -10000 0 -0.81 33 33
mol:Ca2+ -0.009 0.023 -10000 0 -0.079 13 13
MAPK3 0.04 0.11 -10000 0 -10000 0 0
MAPK1 0.021 0.087 -10000 0 -0.41 1 1
PIK3R1 0.017 0 -10000 0 -10000 0 0
mol:IP3 0 0.002 -10000 0 -0.005 33 33
cAMP biosynthetic process 0.008 0.02 -10000 0 -10000 0 0
GNG2 0.017 0 -10000 0 -10000 0 0
potassium channel inhibitor activity 0 0.002 -10000 0 -0.005 33 33
HRAS/GTP -0.004 0.025 -10000 0 -10000 0 0
actin cytoskeleton reorganization 0 0 -10000 0 -10000 0 0
SRC 0.017 0.002 -10000 0 -10000 0 0
voltage-gated calcium channel activity 0 0.002 -10000 0 -0.005 33 33
PI3K 0 0 -10000 0 -10000 0 0
apoptosis -0.014 0.16 0.37 31 -10000 0 31
T-DHT/AR/PELP1 0 0.031 -10000 0 -0.47 1 1
HRAS/GDP -0.001 0.021 -10000 0 -10000 0 0
CREB1 0.012 0.17 -10000 0 -0.4 31 31
RAC1-CDC42/GTP 0 0 -10000 0 -10000 0 0
AR 0.013 0.049 -10000 0 -0.72 1 1
GNB1 0.017 0 -10000 0 -10000 0 0
RAF1 0.042 0.043 -10000 0 -10000 0 0
RAC1-CDC42/GDP -0.001 0.019 -10000 0 -10000 0 0
T-DHT/AR/PELP1/Src 0 0.028 -10000 0 -0.42 1 1
MAP2K2 0.048 0.053 -10000 0 -10000 0 0
T-DHT/AR/PELP1/Src/PI3K 0.04 0.018 -10000 0 -10000 0 0
GNAZ 0.017 0 -10000 0 -10000 0 0
SHBG 0.017 0 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP 0.032 0.082 -10000 0 -10000 0 0
mol:T-DHT 0 0.001 -10000 0 -0.003 33 33
RAC1 0.017 0 -10000 0 -10000 0 0
GNRH1 0.015 0.001 -10000 0 -10000 0 0
Gi family/GTP -0.029 0.074 -10000 0 -10000 0 0
CDC42 0.017 0 -10000 0 -10000 0 0
Signaling events mediated by VEGFR1 and VEGFR2

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin -0.002 0.036 -9999 0 -0.54 1 1
AKT1 0.04 0.17 -9999 0 -0.66 2 2
PTK2B 0.02 0.15 -9999 0 -0.5 6 6
VEGFR2 homodimer/Frs2 -0.01 0.067 -9999 0 -0.47 1 1
CAV1 0.004 0.095 -9999 0 -0.7 4 4
CALM1 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.06 0.14 -9999 0 -0.57 7 7
endothelial cell proliferation 0.04 0.18 -9999 0 -0.65 3 3
mol:Ca2+ -0.03 0.24 -9999 0 -0.73 14 14
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.054 0.13 -9999 0 -0.54 6 6
RP11-342D11.1 -0.015 0.2 -9999 0 -0.66 10 10
CDH5 0.017 0 -9999 0 -10000 0 0
VEGFA homodimer -0.044 0.14 -9999 0 -0.49 9 9
SHC1 0.017 0 -9999 0 -10000 0 0
SHC2 -0.019 0.16 -9999 0 -0.72 11 11
HRAS/GDP -0.063 0.14 -9999 0 -0.58 7 7
SH2D2A -0.009 0.14 -9999 0 -0.72 8 8
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.06 0.12 -9999 0 -0.66 3 3
VEGFR2 homodimer/VEGFA homodimer/TsAd -0.073 0.15 -9999 0 -0.57 7 7
VEGFR1 homodimer -0.019 0.16 -9999 0 -0.72 11 11
SHC/GRB2/SOS1 -0.07 0.15 -9999 0 -0.64 8 8
GRB10 -0.026 0.26 -9999 0 -0.77 17 17
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
GRB2 0.017 0 -9999 0 -10000 0 0
PAK1 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.059 0.14 -9999 0 -0.55 8 8
HRAS 0.017 0 -9999 0 -10000 0 0
VEGF/Rho/ROCK1/Integrin Complex 0.039 0.081 -9999 0 -10000 0 0
HIF1A 0.01 0.07 -9999 0 -0.72 2 2
FRS2 0.017 0 -9999 0 -10000 0 0
oxygen and reactive oxygen species metabolic process -0.054 0.13 -9999 0 -0.53 6 6
mol:GTP 0 0 -9999 0 -10000 0 0
FLT4 0.017 0 -9999 0 -10000 0 0
Nck/Pak 0 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Fyn -0.061 0.14 -9999 0 -0.57 8 8
mol:GDP -0.068 0.15 -9999 0 -0.61 8 8
mol:NADP 0.032 0.16 -9999 0 -0.56 3 3
eNOS/Hsp90 0.037 0.15 -9999 0 -0.52 3 3
PIK3R1 0.017 0 -9999 0 -10000 0 0
mol:IP3 -0.031 0.24 -9999 0 -0.75 14 14
HIF1A/ARNT -0.005 0.051 -9999 0 -0.54 2 2
SHB -0.016 0.15 -9999 0 -0.72 10 10
VEGFA -0.054 0.22 -9999 0 -0.74 21 21
VEGFC 0.008 0.075 -9999 0 -0.63 3 3
FAK1/Vinculin 0.049 0.14 -9999 0 -10000 0 0
mol:Ca ++ 0 0 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.056 0.13 -9999 0 -0.54 6 6
PTPN6 0.017 0 -9999 0 -10000 0 0
EPAS1 0.008 0.11 -9999 0 -0.61 7 7
mol:L-citrulline 0.032 0.16 -9999 0 -0.56 3 3
ITGAV 0.014 0.049 -9999 0 -0.72 1 1
PIK3CA 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 -0.054 0.13 -9999 0 -0.54 6 6
VEGFR2 homodimer/VEGFA homodimer -0.088 0.18 -9999 0 -0.72 10 10
VEGFR2/3 heterodimer -0.01 0.067 -9999 0 -0.47 1 1
VEGFB 0.017 0 -9999 0 -10000 0 0
MAPK11 0.005 0.2 -9999 0 -0.64 10 10
VEGFR2 homodimer 0.03 0.092 -9999 0 -0.56 1 1
FLT1 -0.019 0.16 -9999 0 -0.72 11 11
NEDD4 -0.003 0.12 -9999 0 -0.73 6 6
MAPK3 -0.018 0.22 -9999 0 -0.66 14 14
MAPK1 -0.017 0.22 -9999 0 -0.66 14 14
VEGFA145/NRP2 -0.055 0.17 -9999 0 -0.57 21 21
VEGFR1/2 heterodimer -0.033 0.12 -9999 0 -0.46 5 5
KDR 0.03 0.092 -9999 0 -0.56 1 1
VEGFA165/NRP1/VEGFR2 homodimer -0.079 0.17 -9999 0 -0.65 11 11
SRC 0.017 0 -9999 0 -10000 0 0
platelet activating factor biosynthetic process -0.016 0.23 -9999 0 -0.67 14 14
PI3K -0.079 0.16 -9999 0 -0.7 5 5
VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.06 0.14 -9999 0 -0.57 7 7
FES -0.008 0.21 -9999 0 -0.7 10 10
GAB1 -0.068 0.14 -9999 0 -0.56 8 8
VEGFR2 homodimer/VEGFA homodimer/Src -0.06 0.14 -9999 0 -0.57 7 7
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
SOS1 0.017 0 -9999 0 -10000 0 0
ARNT 0.017 0 -9999 0 -10000 0 0
eNOS/Caveolin-1 0.033 0.16 -9999 0 -0.57 3 3
VEGFR2 homodimer/VEGFA homodimer/Yes -0.06 0.14 -9999 0 -0.57 7 7
PI3K/GAB1 0.041 0.17 -9999 0 -0.66 2 2
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.05 0.12 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer -0.017 0.072 -9999 0 -10000 0 0
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
CDC42 -0.005 0.21 -9999 0 -0.67 10 10
actin cytoskeleton reorganization -0.073 0.15 -9999 0 -0.56 7 7
PTK2 0.041 0.14 -9999 0 -10000 0 0
EDG1 -0.026 0.26 -9999 0 -0.77 17 17
mol:DAG -0.031 0.24 -9999 0 -0.75 14 14
CaM/Ca2+ -0.092 0.19 -9999 0 -0.68 14 14
MAP2K3 0.008 0.2 -9999 0 -0.65 8 8
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.1 0.23 -9999 0 -0.79 17 17
PLCG1 -0.032 0.25 -9999 0 -0.76 14 14
VEGFR2 homodimer/VEGFA homodimer/Src/Shb -0.071 0.15 -9999 0 -0.56 9 9
IQGAP1 0.017 0 -9999 0 -10000 0 0
YES1 0.017 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.061 0.14 -9999 0 -0.57 7 7
VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.06 0.14 -9999 0 -0.57 7 7
cell migration 0.078 0.12 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.074 0.14 -9999 0 -0.63 5 5
FYN 0.014 0.043 -9999 0 -0.63 1 1
VEGFB/NRP1 -0.074 0.16 -9999 0 -0.62 10 10
mol:NO 0.032 0.16 -9999 0 -0.56 3 3
PXN 0.017 0 -9999 0 -10000 0 0
HRAS/GTP -0.063 0.14 -9999 0 -0.58 7 7
VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.1 0.23 -9999 0 -0.79 17 17
VHL 0.014 0.049 -9999 0 -0.72 1 1
ITGB3 0.017 0 -9999 0 -10000 0 0
NOS3 0.029 0.17 -9999 0 -0.65 3 3
VEGFR2 homodimer/VEGFA homodimer/Sck -0.08 0.17 -9999 0 -0.58 12 12
RAC1 0.017 0 -9999 0 -10000 0 0
PRKCA -0.018 0.23 -9999 0 -0.68 15 15
PRKCB -0.027 0.23 -9999 0 -0.69 14 14
VCL 0.017 0 -9999 0 -10000 0 0
VEGFA165/NRP1 -0.017 0.2 -9999 0 -0.67 10 10
VEGFR1/2 heterodimer/VEGFA homodimer -0.079 0.18 -9999 0 -0.67 10 10
VEGFA165/NRP2 -0.055 0.17 -9999 0 -0.57 21 21
MAPKKK cascade -0.079 0.18 -9999 0 -0.75 9 9
NRP2 0.014 0.049 -9999 0 -0.72 1 1
VEGFC homodimer 0.008 0.075 -9999 0 -0.63 3 3
NCK1 0.017 0 -9999 0 -10000 0 0
ROCK1 0.017 0 -9999 0 -10000 0 0
FAK1/Paxillin 0.049 0.14 -9999 0 -10000 0 0
MAP3K13 -0.005 0.21 -9999 0 -0.67 10 10
PDPK1 0.027 0.18 -9999 0 -0.69 2 2
Stabilization and expansion of the E-cadherin adherens junction

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization 0.002 0.11 -9999 0 -0.66 2 2
epithelial cell differentiation -0.019 0.079 -9999 0 -10000 0 0
CYFIP2 0.011 0.061 -9999 0 -0.63 2 2
ENAH 0.061 0.1 -9999 0 -10000 0 0
EGFR 0.002 0.099 -9999 0 -0.65 5 5
EPHA2 -0.016 0.15 -9999 0 -0.72 10 10
MYO6 0.03 0.089 -9999 0 -10000 0 0
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
ABI1/Sra1/Nap1 -0.005 0.047 -9999 0 -0.41 3 3
AQP5 -0.034 0.091 -9999 0 -0.57 1 1
CTNND1 0.017 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0.032 0.084 -9999 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion 0.016 0.11 -9999 0 -0.61 1 1
EGF -0.18 0.31 -9999 0 -0.67 65 65
NCKAP1 0.014 0.049 -9999 0 -0.72 1 1
AQP3 -0.032 0.087 -9999 0 -0.53 1 1
cortical microtubule organization -0.019 0.079 -9999 0 -10000 0 0
GO:0000145 0.031 0.081 -9999 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.019 0.08 -9999 0 -10000 0 0
MLLT4 0.017 0 -9999 0 -10000 0 0
ARF6/GDP -0.027 0.1 -9999 0 -0.59 5 5
ARF6 0.017 0 -9999 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 -0.018 0.084 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
VASP 0.047 0.082 -9999 0 -10000 0 0
PVRL2 0.014 0.049 -9999 0 -0.72 1 1
ZYX 0.03 0.089 -9999 0 -10000 0 0
ARF6/GTP -0.017 0.077 -9999 0 -10000 0 0
CDH1 0 0.1 -9999 0 -0.63 6 6
EGFR/EGFR/EGF/EGF -0.11 0.16 -9999 0 -0.66 4 4
RhoA/GDP -0.017 0.073 -9999 0 -10000 0 0
actin cytoskeleton organization 0.039 0.085 -9999 0 -10000 0 0
IGF-1R heterotetramer 0.017 0 -9999 0 -10000 0 0
GIT1 0.017 0 -9999 0 -10000 0 0
IGF1R 0.017 0 -9999 0 -10000 0 0
IGF1 -0.35 0.32 -9999 0 -0.63 126 126
DIAPH1 -0.007 0.069 -9999 0 -0.71 2 2
Wnt receptor signaling pathway 0.019 0.079 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
RhoA/GTP -0.027 0.1 -9999 0 -0.59 5 5
CTNNA1 0.017 0 -9999 0 -10000 0 0
VCL 0.04 0.087 -9999 0 -10000 0 0
EFNA1 0.017 0 -9999 0 -10000 0 0
LPP 0.041 0.085 -9999 0 -10000 0 0
Ephrin A1/EPHA2 -0.033 0.12 -9999 0 -0.69 5 5
SEC6/SEC8 -0.016 0.065 -9999 0 -10000 0 0
MGAT3 0.016 0.11 -9999 0 -0.63 1 1
HGF/MET -0.18 0.18 -9999 0 -0.68 5 5
HGF 0.01 0.07 -9999 0 -0.72 2 2
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.11 -9999 0 -0.67 2 2
actin cable formation 0.086 0.092 -9999 0 -0.41 1 1
KIAA1543 0.041 0.09 -9999 0 -0.6 1 1
KIFC3 0.025 0.11 -9999 0 -0.75 2 2
NCK1 0.017 0 -9999 0 -10000 0 0
EXOC3 0.017 0 -9999 0 -10000 0 0
ACTN1 0.032 0.085 -9999 0 -10000 0 0
NCK1/GIT1 0 0 -9999 0 -10000 0 0
mol:GDP -0.019 0.079 -9999 0 -10000 0 0
EXOC4 0.017 0 -9999 0 -10000 0 0
STX4 0.032 0.085 -9999 0 -10000 0 0
PIP5K1C 0.032 0.085 -9999 0 -10000 0 0
LIMA1 -0.035 0.18 -9999 0 -0.63 18 18
ABI1 0.017 0 -9999 0 -10000 0 0
ROCK1 -0.023 0.089 -9999 0 -0.5 5 5
adherens junction assembly 0.058 0.1 -9999 0 -0.58 3 3
IGF-1R heterotetramer/IGF1 -0.17 0.16 -9999 0 -0.62 6 6
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.036 -9999 0 -0.54 1 1
MET -0.32 0.37 -9999 0 -0.72 101 101
PLEKHA7 0.032 0.085 -9999 0 -10000 0 0
mol:GTP -0.018 0.084 -9999 0 -10000 0 0
establishment of epithelial cell apical/basal polarity 0.066 0.08 -9999 0 -10000 0 0
cortical actin cytoskeleton stabilization 0.002 0.11 -9999 0 -0.66 2 2
regulation of cell-cell adhesion 0.039 0.085 -9999 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.11 -9999 0 -0.67 2 2
Class I PI3K signaling events

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP 0.003 0.057 0.27 6 -10000 0 6
DAPP1 -0.038 0.16 -10000 0 -0.56 11 11
Src family/SYK family/BLNK-LAT/BTK-ITK -0.039 0.21 -10000 0 -0.66 11 11
mol:DAG -0.037 0.13 0.23 1 -0.28 13 14
HRAS 0.018 0.003 -10000 0 -10000 0 0
RAP1A 0.017 0.003 -10000 0 -10000 0 0
ARF5/GDP 0.033 0.069 -10000 0 -10000 0 0
PLCG2 -0.3 0.32 -10000 0 -0.63 111 111
PLCG1 -0.033 0.18 -10000 0 -0.72 15 15
ARF5 0.017 0 -10000 0 -10000 0 0
mol:GTP 0.002 0.057 0.25 6 -10000 0 6
ARF1/GTP 0.002 0.054 0.25 6 -10000 0 6
RHOA 0.017 0 -10000 0 -10000 0 0
YES1 0.017 0 -10000 0 -10000 0 0
RAP1A/GTP 0.002 0.055 0.24 6 -10000 0 6
ADAP1 0.002 0.054 0.24 6 -10000 0 6
ARAP3 0.002 0.056 0.25 6 -10000 0 6
INPPL1 0.017 0 -10000 0 -10000 0 0
PREX1 0.017 0 -10000 0 -10000 0 0
ARHGEF6 0.011 0.061 -10000 0 -0.63 2 2
ARHGEF7 0.017 0 -10000 0 -10000 0 0
ARF1 0.017 0 -10000 0 -10000 0 0
NRAS 0.008 0.085 -10000 0 -0.72 3 3
FYN 0.014 0.043 -10000 0 -0.63 1 1
ARF6 0.017 0 -10000 0 -10000 0 0
FGR 0.017 0 -10000 0 -10000 0 0
mol:Ca2+ -0.01 0.071 -10000 0 -10000 0 0
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.011 0.061 -10000 0 -0.63 2 2
ZAP70 0.017 0 -10000 0 -10000 0 0
mol:IP3 -0.019 0.095 -10000 0 -0.28 1 1
LYN 0.017 0 -10000 0 -10000 0 0
ARF1/GDP 0.033 0.069 -10000 0 -10000 0 0
RhoA/GDP -0.002 0.057 0.26 5 -10000 0 5
PDK1/Src/Hsp90 -0.002 0.03 -10000 0 -0.46 1 1
BLNK 0 0.1 -10000 0 -0.63 6 6
actin cytoskeleton reorganization 0.056 0.079 -10000 0 -0.4 1 1
SRC 0.017 0 -10000 0 -10000 0 0
PLEKHA2 0.023 0.047 -10000 0 -0.47 2 2
RAC1 0.017 0 -10000 0 -10000 0 0
PTEN -0.016 0.098 -10000 0 -0.61 6 6
HSP90AA1 0.014 0.049 -10000 0 -0.72 1 1
ARF6/GTP 0.003 0.057 0.27 6 -10000 0 6
RhoA/GTP 0.002 0.054 -10000 0 -10000 0 0
Src family/SYK family/BLNK-LAT -0.021 0.15 -10000 0 -0.66 3 3
BLK -0.17 0.29 -10000 0 -0.63 63 63
PDPK1 0.017 0 -10000 0 -10000 0 0
CYTH1 0.002 0.054 0.24 6 -10000 0 6
HCK -0.044 0.19 -10000 0 -0.63 21 21
CYTH3 0.002 0.054 0.24 6 -10000 0 6
CYTH2 0.002 0.054 0.24 6 -10000 0 6
KRAS 0.018 0.003 -10000 0 -10000 0 0
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.003 0.038 0.2 6 -10000 0 6
SGK1 0.003 0.04 0.21 6 -10000 0 6
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.024 0.072 -10000 0 -0.31 3 3
SOS1 0.017 0 -10000 0 -10000 0 0
SYK 0.014 0.049 -10000 0 -0.72 1 1
ARF6/GDP -0.002 0.058 0.27 5 -10000 0 5
mol:PI-3-4-5-P3 0.004 0.065 0.32 6 -10000 0 6
ARAP3/RAP1A/GTP 0.002 0.055 0.24 6 -10000 0 6
VAV1 -0.041 0.18 -10000 0 -0.63 20 20
mol:PI-3-4-P2 0.016 0 -10000 0 -10000 0 0
RAS family/GTP/PI3K Class I 0.027 0.044 -10000 0 -0.35 3 3
PLEKHA1 0.027 0 -10000 0 -10000 0 0
Rac1/GDP 0.033 0.069 -10000 0 -10000 0 0
LAT 0.01 0.07 -10000 0 -0.72 2 2
Rac1/GTP 0.03 0.088 -10000 0 -0.51 2 2
ITK 0.002 0.054 0.25 6 -10000 0 6
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.059 0.17 0.26 1 -0.4 14 15
LCK 0.011 0.065 -10000 0 -0.68 2 2
BTK -0.045 0.13 0.25 5 -0.64 2 7
Plasma membrane estrogen receptor signaling

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.009 0.052 -10000 0 -10000 0 0
ER alpha/Gai/GDP/Gbeta gamma 0.022 0.11 -10000 0 -0.57 3 3
AKT1 0.026 0.14 -10000 0 -0.82 6 6
PIK3CA 0.017 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/PI3K 0.022 0.14 -10000 0 -0.84 6 6
mol:Ca2+ -0.09 0.19 -10000 0 -0.43 14 14
IGF1R 0.017 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/Striatin -0.015 0.077 -10000 0 -0.41 8 8
SHC1 0.017 0 -10000 0 -10000 0 0
apoptosis -0.026 0.14 0.78 6 -10000 0 6
RhoA/GTP -0.012 0.057 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.028 0.088 -10000 0 -0.58 3 3
regulation of stress fiber formation -0.06 0.057 -10000 0 -10000 0 0
E2/ERA-ERB (dimer) -0.011 0.064 -10000 0 -0.4 6 6
KRAS 0.017 0 -10000 0 -10000 0 0
G13/GTP -0.01 0.058 -10000 0 -0.36 6 6
pseudopodium formation 0.06 0.057 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1 -0.011 0.064 -10000 0 -0.4 6 6
GRB2 0.017 0 -10000 0 -10000 0 0
GNG2 0.017 0 -10000 0 -10000 0 0
GNAO1 0.017 0 -10000 0 -10000 0 0
HRAS 0.017 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO 0.04 0.11 -10000 0 -0.54 6 6
E2/ER beta (dimer) 0 0 -10000 0 -10000 0 0
mol:GDP -0.014 0.071 -10000 0 -0.42 6 6
mol:NADP 0.04 0.11 -10000 0 -0.54 6 6
PIK3R1 0.017 0 -10000 0 -10000 0 0
mol:IP3 -0.095 0.2 -10000 0 -0.44 14 14
IGF-1R heterotetramer 0.017 0 -10000 0 -10000 0 0
PLCB1 -0.11 0.2 -10000 0 -0.38 74 74
PLCB2 0.009 0.11 -10000 0 -0.44 9 9
IGF1 -0.35 0.32 -10000 0 -0.63 126 126
mol:L-citrulline 0.04 0.11 -10000 0 -0.54 6 6
RHOA 0.017 0 -10000 0 -10000 0 0
Gai/GDP -0.031 0.078 -10000 0 -10000 0 0
JNK cascade 0 0 -10000 0 -10000 0 0
BCAR1 0.017 0 -10000 0 -10000 0 0
ESR2 0.017 0 -10000 0 -10000 0 0
GNAQ 0 0 -10000 0 -10000 0 0
ESR1 0 0.1 -10000 0 -0.63 6 6
Gq family/GDP/Gbeta gamma 0.017 0.11 -10000 0 -0.48 6 6
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.042 0.056 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.028 0.088 -10000 0 -0.49 6 6
GNAZ 0.017 0 -10000 0 -10000 0 0
E2/ER alpha (dimer) -0.013 0.076 -10000 0 -0.47 6 6
STRN 0.01 0.07 -10000 0 -0.72 2 2
GNAL 0.017 0 -10000 0 -10000 0 0
PELP1 0.017 0 -10000 0 -10000 0 0
MAPK11 0.023 0.033 -10000 0 -0.47 1 1
GNAI2 0.017 0 -10000 0 -10000 0 0
GNAI3 0.017 0 -10000 0 -10000 0 0
GNAI1 -0.07 0.22 -10000 0 -0.63 30 30
HBEGF 0.036 0.11 -10000 0 -0.48 3 3
cAMP biosynthetic process -0.008 0.05 -10000 0 -0.31 6 6
SRC 0.032 0.11 -10000 0 -0.54 3 3
PI3K 0 0 -10000 0 -10000 0 0
GNB1 0.017 0 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma -0.011 0.059 -10000 0 -10000 0 0
SOS1 0.017 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.14 0.14 -10000 0 -0.59 6 6
Gs family/GTP -0.008 0.051 -10000 0 -0.32 6 6
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP -0.006 0.048 -10000 0 -0.42 3 3
vasodilation 0.04 0.1 -10000 0 -0.51 6 6
mol:DAG -0.095 0.2 -10000 0 -0.44 14 14
Gs family/GDP/Gbeta gamma -0.011 0.055 -10000 0 -10000 0 0
MSN 0.062 0.061 -10000 0 -10000 0 0
Gq family/GTP -0.034 0.1 -10000 0 -0.47 9 9
mol:PI-3-4-5-P3 0.022 0.14 -10000 0 -0.8 6 6
NRAS 0.007 0.085 -10000 0 -0.72 3 3
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion -0.04 0.1 0.51 6 -10000 0 6
GRB2/SOS1 0 0 -10000 0 -10000 0 0
RhoA/GDP -0.013 0.065 -10000 0 -0.39 6 6
NOS3 0.04 0.12 -10000 0 -0.57 6 6
GNA11 0 0.1 -10000 0 -0.63 6 6
MAPKKK cascade 0.047 0.12 -10000 0 -0.62 6 6
E2/ER alpha (dimer)/PELP1/Src -0.03 0.094 -10000 0 -0.52 6 6
ruffle organization 0.06 0.057 -10000 0 -10000 0 0
ROCK2 0.054 0.065 -10000 0 -10000 0 0
GNA14 -0.009 0.13 -10000 0 -0.63 9 9
GNA15 -0.006 0.13 -10000 0 -0.72 7 7
GNA13 0.017 0 -10000 0 -10000 0 0
MMP9 0.029 0.12 -10000 0 -0.5 3 3
MMP2 0.038 0.11 -10000 0 -0.5 3 3
Coregulation of Androgen receptor activity

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.019 0.001 -9999 0 -10000 0 0
SVIL 0.013 0.061 -9999 0 -0.63 2 2
ZNF318 -0.002 0.049 -9999 0 -0.73 1 1
JMJD2C 0.027 0.001 -9999 0 -10000 0 0
T-DHT/AR/Ubc9 -0.004 0.043 -9999 0 -0.45 2 2
CARM1 0.017 0 -9999 0 -10000 0 0
PRDX1 0.017 0 -9999 0 -10000 0 0
PELP1 0.016 0.001 -9999 0 -10000 0 0
CTNNB1 -0.001 0.12 -9999 0 -0.72 6 6
AKT1 0.016 0.002 -9999 0 -10000 0 0
PTK2B 0.018 0.001 -9999 0 -10000 0 0
MED1 0.006 0.085 -9999 0 -0.72 3 3
MAK -0.012 0.097 -9999 0 -0.73 4 4
response to oxidative stress -0.001 0.001 -9999 0 -10000 0 0
HIP1 0.012 0.07 -9999 0 -0.72 2 2
GSN -0.088 0.24 -9999 0 -0.63 37 37
NCOA2 0.017 0 -9999 0 -10000 0 0
NCOA6 0.016 0.049 -9999 0 -0.72 1 1
DNA-PK -0.038 0.13 -9999 0 -0.46 19 19
NCOA4 0.017 0 -9999 0 -10000 0 0
PIAS3 0.015 0.049 -9999 0 -0.72 1 1
cell proliferation -0.007 0.054 -9999 0 -0.4 4 4
XRCC5 0.016 0.001 -9999 0 -10000 0 0
UBE3A 0.02 0.003 -9999 0 -10000 0 0
T-DHT/AR/SNURF 0.027 0.034 -9999 0 -0.46 1 1
FHL2 -0.003 0.04 -9999 0 -0.56 1 1
RANBP9 0.019 0.001 -9999 0 -10000 0 0
JMJD1A 0.028 0.01 -9999 0 -10000 0 0
CDK6 0.01 0.07 -9999 0 -0.72 2 2
TGFB1I1 0.019 0.001 -9999 0 -10000 0 0
T-DHT/AR/CyclinD1 -0.073 0.17 -9999 0 -0.45 36 36
XRCC6 0.016 0.001 -9999 0 -10000 0 0
T-DHT/AR 0.063 0.038 -9999 0 -0.43 1 1
CTDSP1 0.018 0.001 -9999 0 -10000 0 0
CTDSP2 0.003 0.075 -9999 0 -0.64 3 3
BRCA1 0.006 0.098 -9999 0 -0.72 4 4
TCF4 0.015 0.003 -9999 0 -10000 0 0
CDKN2A -0.22 0.34 -9999 0 -0.72 70 70
SRF 0.026 0.008 -9999 0 -10000 0 0
NKX3-1 -0.002 0.017 -9999 0 -10000 0 0
KLK3 0.032 0.061 -9999 0 -10000 0 0
TMF1 0.017 0.001 -9999 0 -10000 0 0
HNRNPA1 0.015 0.002 -9999 0 -10000 0 0
AOF2 0.013 0.07 -9999 0 -0.72 2 2
APPL1 0.029 0.004 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 -0.002 0.031 -9999 0 -0.45 1 1
AR 0.023 0.049 -9999 0 -0.71 1 1
UBA3 0.001 0.001 -9999 0 -10000 0 0
PATZ1 0.015 0.002 -9999 0 -10000 0 0
PAWR 0.017 0.001 -9999 0 -10000 0 0
PRKDC -0.047 0.21 -9999 0 -0.72 19 19
PA2G4 0.012 0.049 -9999 0 -0.72 1 1
UBE2I 0.014 0.049 -9999 0 -0.72 1 1
T-DHT/AR/Cyclin D3/CDK11 p58 -0.002 0.028 -9999 0 -0.41 1 1
RPS6KA3 0.019 0.001 -9999 0 -10000 0 0
T-DHT/AR/ARA70 -0.002 0.03 -9999 0 -0.44 1 1
LATS2 0.015 0.002 -9999 0 -10000 0 0
T-DHT/AR/PRX1 -0.002 0.028 -9999 0 -0.41 1 1
Cyclin D3/CDK11 p58 0 0 -9999 0 -10000 0 0
VAV3 -0.08 0.23 -9999 0 -0.63 34 34
KLK2 0 0.01 -9999 0 -10000 0 0
CASP8 0.016 0.001 -9999 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 0.049 0.031 -9999 0 -10000 0 0
TMPRSS2 0.056 0.073 -9999 0 -1 1 1
CCND1 -0.098 0.27 -9999 0 -0.72 35 35
PIAS1 0.02 0.003 -9999 0 -10000 0 0
mol:T-DHT 0.009 0.007 -9999 0 -0.065 2 2
CDC2L1 0 0 -9999 0 -10000 0 0
PIAS4 0.021 0.005 -9999 0 -10000 0 0
T-DHT/AR/CDK6 -0.006 0.052 -9999 0 -0.45 3 3
CMTM2 0 0.11 -9999 0 -0.72 5 5
SNURF 0 0 -9999 0 -10000 0 0
ZMIZ1 0.026 0.006 -9999 0 -10000 0 0
CCND3 0.017 0 -9999 0 -10000 0 0
TGIF1 -0.071 0.24 -9999 0 -0.72 26 26
FKBP4 0.013 0.07 -9999 0 -0.72 2 2
IFN-gamma pathway

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.082 0.16 -9999 0 -0.71 4 4
positive regulation of NF-kappaB transcription factor activity 0 0.001 -9999 0 -10000 0 0
CRKL 0.017 0 -9999 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 -0.094 0.2 -9999 0 -0.69 17 17
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.019 0.072 -9999 0 -0.54 4 4
antigen processing and presentation of peptide antigen via MHC class I -0.045 0.084 -9999 0 -0.34 6 6
CaM/Ca2+ -0.075 0.14 -9999 0 -0.65 4 4
RAP1A 0.017 0 -9999 0 -10000 0 0
STAT1 (dimer)/SHP2 -0.064 0.25 -9999 0 -0.78 17 17
AKT1 -0.007 0.16 -9999 0 -0.57 4 4
MAP2K1 -0.01 0.17 -9999 0 -0.62 4 4
MAP3K11 -0.026 0.17 -9999 0 -0.66 4 4
IFNGR1 0.012 0.014 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKII -0.023 0.049 -9999 0 -10000 0 0
Rap1/GTP -0.053 0.1 -9999 0 -0.48 4 4
CRKL/C3G 0 0 -9999 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP -0.087 0.17 -9999 0 -0.75 4 4
CEBPB 0.037 0.16 -9999 0 -0.52 1 1
STAT3 0.017 0 -9999 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.075 0.15 -9999 0 -0.67 4 4
STAT1 -0.06 0.25 -9999 0 -0.78 17 17
CALM1 0.017 0 -9999 0 -10000 0 0
IFN-gamma (dimer) -0.14 0.31 -9999 0 -0.72 50 50
PIK3CA 0.017 0 -9999 0 -10000 0 0
STAT1 (dimer)/PIAS1 -0.05 0.24 -9999 0 -0.72 17 17
CEBPB/PTGES2/Cbp/p300 -0.029 0.06 -9999 0 -10000 0 0
mol:Ca2+ -0.081 0.16 -9999 0 -0.7 4 4
MAPK3 0.01 0.17 -9999 0 -0.64 6 6
STAT1 (dimer) -0.06 0.12 -9999 0 -0.5 6 6
MAPK1 0.014 0.16 -9999 0 -0.56 5 5
JAK2 -0.001 0.1 -9999 0 -0.76 4 4
PIK3R1 0.017 0 -9999 0 -10000 0 0
JAK1 0.012 0.014 -9999 0 -10000 0 0
CAMK2D 0.017 0 -9999 0 -10000 0 0
DAPK1 0.05 0.12 -9999 0 -0.5 1 1
SMAD7 0.044 0.082 -9999 0 -0.29 1 1
CBL/CRKL/C3G -0.066 0.13 -9999 0 -0.59 4 4
PI3K -0.071 0.14 -9999 0 -0.64 4 4
IFNG -0.14 0.31 -9999 0 -0.72 50 50
apoptosis 0.034 0.1 -9999 0 -0.36 1 1
CAMK2G 0.017 0 -9999 0 -10000 0 0
STAT3 (dimer) 0.017 0 -9999 0 -10000 0 0
CAMK2A 0.017 0 -9999 0 -10000 0 0
CAMK2B 0.014 0.049 -9999 0 -0.72 1 1
FRAP1 0.008 0.15 -9999 0 -0.52 4 4
PRKCD -0.003 0.16 -9999 0 -0.59 4 4
RAP1B 0.017 0 -9999 0 -10000 0 0
negative regulation of cell growth -0.045 0.084 -9999 0 -0.34 6 6
PTPN2 0.017 0 -9999 0 -10000 0 0
EP300 0.018 0.001 -9999 0 -10000 0 0
IRF1 0.012 0.19 -9999 0 -0.62 6 6
STAT1 (dimer)/PIASy -0.1 0.21 -9999 0 -0.73 17 17
SOCS1 0.008 0.043 -9999 0 -0.56 1 1
mol:GDP -0.064 0.12 -9999 0 -0.56 4 4
CASP1 0.03 0.12 -9999 0 -0.3 16 16
PTGES2 0.017 0 -9999 0 -10000 0 0
IRF9 0.057 0.06 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.069 0.14 -9999 0 -0.61 4 4
RAP1/GDP -0.054 0.1 -9999 0 -0.48 4 4
CBL -0.027 0.17 -9999 0 -0.66 4 4
MAP3K1 -0.025 0.17 -9999 0 -0.66 4 4
PIAS1 0.017 0 -9999 0 -10000 0 0
PIAS4 0.016 0.001 -9999 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.045 0.084 -9999 0 -0.34 6 6
PTPN11 -0.04 0.18 -9999 0 -0.7 4 4
CREBBP 0.018 0.001 -9999 0 -10000 0 0
RAPGEF1 0.017 0 -9999 0 -10000 0 0
Signaling mediated by p38-gamma and p38-delta

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K 0.041 0 -9999 0 -10000 0 0
SNTA1 0.017 0 -9999 0 -10000 0 0
response to hypoxia 0 0 -9999 0 -10000 0 0
STMN1 0.039 0.033 -9999 0 -0.46 1 1
MAPK12 -0.025 0.14 -9999 0 -0.47 6 6
CCND1 -0.033 0.1 -9999 0 -0.34 11 11
p38 gamma/SNTA1 -0.014 0.13 -9999 0 -0.7 1 1
MAP2K3 0.017 0 -9999 0 -10000 0 0
PKN1 0.017 0 -9999 0 -10000 0 0
G2/M transition checkpoint -0.025 0.14 -9999 0 -0.46 6 6
MAP2K6 -0.027 0.13 -9999 0 -0.38 9 9
MAPT 0.022 0.045 -9999 0 -10000 0 0
MAPK13 0.031 0 -9999 0 -10000 0 0
hyperosmotic response 0 0 -9999 0 -10000 0 0
ZAK -0.027 0.12 -9999 0 -0.31 34 34
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.017 0 -9999 0 -10000 0 0
Caspase 8 (4 units) -0.046 0.11 -9999 0 -0.46 8 8
NEF -0.011 0.056 -9999 0 -10000 0 0
NFKBIA 0.016 0.026 -9999 0 -10000 0 0
BIRC3 0.024 0.16 -9999 0 -0.64 12 12
CYCS -0.001 0.16 -9999 0 -0.52 9 9
RIPK1 0.017 0 -9999 0 -10000 0 0
CD247 -0.028 0.17 -9999 0 -0.74 11 11
MAP2K7 0.028 0.11 -9999 0 -0.37 3 3
protein ubiquitination 0.087 0.04 -9999 0 -10000 0 0
CRADD 0.011 0.061 -9999 0 -0.63 2 2
DAXX 0.017 0 -9999 0 -10000 0 0
FAS -0.047 0.19 -9999 0 -0.63 22 22
BID -0.011 0.16 -9999 0 -0.46 17 17
NF-kappa-B/RelA/I kappa B alpha -0.015 0.064 -9999 0 -10000 0 0
TRADD 0.017 0 -9999 0 -10000 0 0
MAP3K5 0.01 0.07 -9999 0 -0.72 2 2
CFLAR 0.017 0 -9999 0 -10000 0 0
FADD 0.017 0 -9999 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha/ubiquitin -0.015 0.064 -9999 0 -10000 0 0
MAPK8 0.037 0.1 -9999 0 -10000 0 0
APAF1 0.01 0.07 -9999 0 -0.72 2 2
TRAF1 0.017 0 -9999 0 -10000 0 0
TRAF2 0.017 0 -9999 0 -10000 0 0
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.01 0.15 -9999 0 -0.5 11 11
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.075 0.045 -9999 0 -10000 0 0
CHUK 0.089 0.041 -9999 0 -10000 0 0
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 -0.034 0.1 -9999 0 -0.71 1 1
TCRz/NEF -0.057 0.17 -9999 0 -0.46 28 28
TNF 0.017 0 -9999 0 -10000 0 0
FASLG -0.058 0.27 -9999 0 -0.81 24 24
NFKB1 0.016 0.026 -9999 0 -10000 0 0
TNFR1A/BAG4/TNF-alpha 0 0 -9999 0 -10000 0 0
CASP6 -0.03 0.079 -9999 0 -10000 0 0
CASP7 -0.002 0.22 -9999 0 -0.6 13 13
RELA 0.016 0.026 -9999 0 -10000 0 0
CASP2 0.017 0 -9999 0 -10000 0 0
CASP3 0.044 0.17 -9999 0 -0.57 10 10
TNFRSF1A 0.017 0 -9999 0 -10000 0 0
TNFR1A/BAG4 0 0 -9999 0 -10000 0 0
CASP8 0.017 0 -9999 0 -10000 0 0
CASP9 0.017 0 -9999 0 -10000 0 0
MAP3K14 0.083 0.044 -9999 0 -10000 0 0
APAF-1/Caspase 9 -0.054 0.12 -9999 0 -0.53 7 7
BCL2 -0.16 0.19 -9999 0 -0.46 35 35
Effects of Botulinum toxin

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A -0.007 0.11 -9999 0 -0.55 9 9
UniProt:P19321 0 0 -9999 0 -10000 0 0
RIMS1/UNC13B 0 0 -9999 0 -10000 0 0
STXBP1 -0.026 0.17 -9999 0 -0.72 13 13
ACh/CHRNA1 0.017 0.022 -9999 0 -10000 0 0
RAB3GAP2/RIMS1/UNC13B 0 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
UniProt:P30996 0 0 -9999 0 -10000 0 0
UniProt:Q60393 0 0 -9999 0 -10000 0 0
CST086 0 0 -9999 0 -10000 0 0
RIMS1 0.017 0 -9999 0 -10000 0 0
mol:ACh 0.007 0.03 -9999 0 -0.12 10 10
RAB3GAP2 0.017 0 -9999 0 -10000 0 0
STX1A/SNAP25/VAMP2 -0.033 0.099 -9999 0 -0.47 2 2
UniProt:P10844 0 0 -9999 0 -10000 0 0
muscle contraction 0.017 0.022 -9999 0 -10000 0 0
UNC13B 0.017 0 -9999 0 -10000 0 0
CHRNA1 0.017 0 -9999 0 -10000 0 0
UniProt:P10845 0 0 -9999 0 -10000 0 0
ACh/Synaptotagmin 1 -0.05 0.17 -9999 0 -0.5 29 29
SNAP25 0.006 0.036 -9999 0 -0.31 3 3
VAMP2 0.009 0 -9999 0 -10000 0 0
SYT1 -0.079 0.25 -9999 0 -0.72 29 29
UniProt:Q00496 0 0 -9999 0 -10000 0 0
STXIA/STXBP1 -0.024 0.15 -9999 0 -0.47 22 22
STX1A/SNAP25 fragment 1/VAMP2 -0.033 0.099 -9999 0 -0.47 2 2
PDGFR-beta signaling pathway

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate -0.083 0.14 -9999 0 -0.46 10 10
PDGFB-D/PDGFRB/SLAP 0.001 0.004 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/APS/CBL 0 0.003 -9999 0 -10000 0 0
AKT1 0.061 0.062 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0.001 -9999 0 -10000 0 0
mol:Sphingosine-1-phosphate -0.06 0.13 -9999 0 -0.42 4 4
PIK3CA 0.017 0 -9999 0 -10000 0 0
FGR -0.01 0.028 -9999 0 -10000 0 0
mol:Ca2+ -0.027 0.079 -9999 0 -0.38 2 2
MYC -0.26 0.25 -9999 0 -0.52 56 56
SHC1 0.017 0 -9999 0 -10000 0 0
HRAS/GDP -0.001 0.035 -9999 0 -10000 0 0
LRP1/PDGFRB/PDGFB -0.002 0.031 -9999 0 -0.46 1 1
GRB10 -0.029 0.18 -9999 0 -0.72 14 14
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
GO:0007205 -0.028 0.079 -9999 0 -0.38 2 2
PTEN 0 0.1 -9999 0 -0.63 6 6
GRB2 0.017 0 -9999 0 -10000 0 0
GRB7 -0.009 0.14 -9999 0 -0.72 8 8
PDGFB-D/PDGFRB/SHP2 -0.002 0.037 -9999 0 -0.55 1 1
PDGFB-D/PDGFRB/GRB10 -0.034 0.13 -9999 0 -0.55 14 14
cell cycle arrest 0.001 0.004 -9999 0 -10000 0 0
HRAS 0.017 0 -9999 0 -10000 0 0
HIF1A 0.066 0.072 -9999 0 -0.53 1 1
GAB1 -0.065 0.1 -9999 0 -0.41 5 5
mol:GTP 0 0 -9999 0 -10000 0 0
DNM2 -0.063 0.1 -9999 0 -0.44 2 2
PDGFB-D/PDGFRB 0.005 0.013 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.001 0.004 -9999 0 -10000 0 0
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB -0.11 0.14 -9999 0 -0.51 10 10
positive regulation of MAPKKK cascade -0.002 0.037 -9999 0 -0.55 1 1
PIK3R1 0.017 0 -9999 0 -10000 0 0
mol:IP3 -0.028 0.08 -9999 0 -0.38 2 2
E5 -0.001 0.002 -9999 0 -10000 0 0
CSK 0.018 0.002 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/GRB7 -0.019 0.1 -9999 0 -0.55 8 8
SHB -0.016 0.15 -9999 0 -0.72 10 10
BLK -0.18 0.29 -9999 0 -0.64 63 63
PTPN2 0.007 0.008 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/SNX15 0.001 0.004 -9999 0 -10000 0 0
BCAR1 0.017 0 -9999 0 -10000 0 0
VAV2 -0.1 0.13 -9999 0 -0.56 5 5
CBL 0.017 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 0.001 0.004 -9999 0 -10000 0 0
LCK -0.014 0.059 -9999 0 -0.74 1 1
PDGFRB 0.006 0.009 -9999 0 -10000 0 0
ACP1 0.017 0 -9999 0 -10000 0 0
HCK -0.065 0.2 -9999 0 -0.68 21 21
ABL1 -0.049 0.091 -9999 0 -0.41 2 2
PDGFB-D/PDGFRB/CBL -0.064 0.1 -9999 0 -0.42 4 4
PTPN1 0.007 0.008 -9999 0 -10000 0 0
SNX15 0.017 0 -9999 0 -10000 0 0
STAT3 0.017 0 -9999 0 -10000 0 0
STAT1 -0.049 0.21 -9999 0 -0.72 20 20
cell proliferation -0.24 0.23 -9999 0 -0.47 56 56
SLA 0.017 0 -9999 0 -10000 0 0
actin cytoskeleton reorganization 0.005 0.082 -9999 0 -10000 0 0
SRC -0.008 0.027 -9999 0 -10000 0 0
PI3K -0.011 0.052 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/GRB7/SHC -0.016 0.085 -9999 0 -0.46 8 8
SH2B2 0 0 -9999 0 -10000 0 0
PLCgamma1/SPHK1 -0.062 0.13 -9999 0 -0.43 4 4
LYN -0.008 0.027 -9999 0 -10000 0 0
LRP1 0.017 0 -9999 0 -10000 0 0
SOS1 0.017 0 -9999 0 -10000 0 0
STAT5B 0.017 0 -9999 0 -10000 0 0
STAT5A 0.017 0 -9999 0 -10000 0 0
NCK1-2/p130 Cas 0.001 0.009 -9999 0 -10000 0 0
SPHK1 -0.074 0.24 -9999 0 -0.72 27 27
EDG1 -0.023 0.15 -9999 0 -0.64 13 13
mol:DAG -0.028 0.08 -9999 0 -0.38 2 2
PLCG1 -0.028 0.081 -9999 0 -0.39 2 2
NHERF/PDGFRB -0.007 0.051 -9999 0 -0.39 4 4
YES1 -0.009 0.028 -9999 0 -10000 0 0
cell migration -0.007 0.051 -9999 0 -0.38 4 4
SHC/Grb2/SOS1 0.001 0.009 -9999 0 -10000 0 0
SLC9A3R2 0.017 0 -9999 0 -10000 0 0
SLC9A3R1 0.005 0.086 -9999 0 -0.63 4 4
NHERF1-2/PDGFRB/PTEN -0.015 0.071 -9999 0 -10000 0 0
FYN -0.011 0.06 -9999 0 -0.81 1 1
DOK1 0.017 0.036 -9999 0 -0.42 1 1
HRAS/GTP 0 0 -9999 0 -10000 0 0
PDGFB 0.014 0.049 -9999 0 -0.72 1 1
RAC1 -0.16 0.18 -9999 0 -0.58 8 8
PRKCD 0.018 0.022 -9999 0 -10000 0 0
FER 0.002 0.085 -9999 0 -0.42 8 8
MAPKKK cascade 0.001 0.015 -9999 0 -10000 0 0
RASA1 0.014 0.046 -9999 0 -0.42 1 1
NCK1 0.017 0 -9999 0 -10000 0 0
NCK2 0.017 0 -9999 0 -10000 0 0
p62DOK/Csk 0.044 0.036 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/SHB -0.024 0.11 -9999 0 -0.55 10 10
chemotaxis -0.048 0.089 -9999 0 -0.4 2 2
STAT1-3-5/STAT1-3-5 -0.03 0.097 -9999 0 -10000 0 0
Bovine Papilomavirus E5/PDGFRB 0.002 0.005 -9999 0 -10000 0 0
PTPRJ 0.017 0 -9999 0 -10000 0 0
Caspase cascade in apoptosis

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 0.037 0.062 -10000 0 -10000 0 0
ACTA1 0.003 0.091 -10000 0 -0.48 1 1
NUMA1 0.037 0.062 -10000 0 -10000 0 0
SPTAN1 0.03 0.073 -10000 0 -10000 0 0
LIMK1 0.009 0.11 -10000 0 -0.41 8 8
BIRC3 -0.019 0.15 -10000 0 -0.66 12 12
BIRC2 0.017 0 -10000 0 -10000 0 0
BAX 0.014 0.049 -10000 0 -0.72 1 1
CASP10 0.019 0.1 -10000 0 -0.46 10 10
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
PTK2 0.037 0.062 -10000 0 -10000 0 0
DIABLO 0.017 0 -10000 0 -10000 0 0
apoptotic nuclear changes 0.03 0.073 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.011 0.061 -10000 0 -0.63 2 2
GSN -0.029 0.15 -10000 0 -0.57 3 3
MADD 0.017 0 -10000 0 -10000 0 0
TFAP2A 0.001 0.083 -10000 0 -10000 0 0
BID 0.016 0.073 -10000 0 -0.48 2 2
MAP3K1 0.021 0.032 -10000 0 -10000 0 0
TRADD 0.017 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 -0.005 0.051 -10000 0 -0.54 2 2
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB 0.028 0.073 -10000 0 -10000 0 0
CASP9 0.017 0.001 -10000 0 -10000 0 0
DNA repair -0.002 0.062 0.26 1 -0.21 6 7
neuron apoptosis 0.035 0.011 -10000 0 -10000 0 0
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis 0.036 0.084 -10000 0 -0.56 1 1
APAF1 0.01 0.07 -10000 0 -0.72 2 2
CASP6 0.049 0.042 -10000 0 -10000 0 0
TRAF2 0.017 0 -10000 0 -10000 0 0
ICAD/CAD 0.035 0.084 -10000 0 -0.56 1 1
CASP7 -0.064 0.19 0.31 9 -0.52 30 39
KRT18 0.023 0.032 -10000 0 -10000 0 0
apoptosis 0.03 0.092 -10000 0 -0.45 1 1
DFFA 0.03 0.073 -10000 0 -10000 0 0
DFFB 0.026 0.087 -10000 0 -0.59 1 1
PARP1 0.002 0.063 0.21 6 -0.26 1 7
actin filament polymerization -0.006 0.12 0.51 2 -10000 0 2
TNF 0.017 0 -10000 0 -10000 0 0
CYCS 0.028 0.051 -10000 0 -0.24 2 2
SATB1 0.025 0.11 -10000 0 -0.48 2 2
SLK 0.028 0.078 -10000 0 -0.38 1 1
p15 BID/BAX 0.021 0.072 -10000 0 -0.42 3 3
CASP2 0.056 0.05 -10000 0 -10000 0 0
JNK cascade -0.021 0.032 -10000 0 -10000 0 0
CASP3 0.02 0.078 -10000 0 -0.36 5 5
LMNB2 0.058 0.042 -10000 0 -10000 0 0
RIPK1 0.017 0 -10000 0 -10000 0 0
CASP4 0.017 0 -10000 0 -10000 0 0
Mammalian IAPs/DIABLO -0.02 0.083 -10000 0 -0.42 3 3
negative regulation of DNA binding 0.002 0.083 -10000 0 -10000 0 0
stress fiber formation 0.028 0.078 -10000 0 -0.38 1 1
GZMB 0.006 0.12 -10000 0 -0.54 10 10
CASP1 -0.003 0.096 -10000 0 -0.35 16 16
LMNB1 0.025 0.064 -10000 0 -10000 0 0
APP 0.036 0.011 -10000 0 -10000 0 0
TNFRSF1A 0.017 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 0.016 0 -10000 0 -10000 0 0
VIM 0.022 0.09 0.28 1 -0.4 3 4
LMNA 0.061 0.037 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.048 0.054 -10000 0 -10000 0 0
LRDD 0.014 0.049 -10000 0 -0.72 1 1
SREBF1 0.028 0.078 -10000 0 -0.38 1 1
APAF-1/Caspase 9 0.004 0.039 -10000 0 -10000 0 0
nuclear fragmentation during apoptosis 0.037 0.061 -10000 0 -10000 0 0
CFL2 0.005 0.12 -10000 0 -0.53 2 2
GAS2 -0.22 0.22 -10000 0 -0.4 119 119
positive regulation of apoptosis 0.047 0.048 -10000 0 -10000 0 0
PRF1 0.004 0.098 -10000 0 -0.72 4 4
FoxO family signaling

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.029 0.1 -9999 0 -10000 0 0
PLK1 0.033 0.2 -9999 0 -0.76 3 3
CDKN1B 0.088 0.15 -9999 0 -10000 0 0
FOXO3 0.023 0.22 -9999 0 -0.71 8 8
KAT2B 0.002 0.025 -9999 0 -0.058 8 8
FOXO1/SIRT1 -0.006 0.1 -9999 0 -0.56 1 1
CAT 0.029 0.22 -9999 0 -0.88 4 4
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
AKT1 0.027 0.022 -9999 0 -10000 0 0
FOXO1 0.019 0.12 -9999 0 -0.61 1 1
MAPK10 0.043 0.055 -9999 0 -0.38 2 2
mol:GTP 0.003 0.002 -9999 0 -10000 0 0
FOXO4 0.13 0.059 -9999 0 -10000 0 0
response to oxidative stress 0.01 0.025 -9999 0 -0.054 7 7
FOXO3A/SIRT1 -0.032 0.16 -9999 0 -0.62 6 6
XPO1 0.018 0.001 -9999 0 -10000 0 0
EP300 0.021 0.002 -9999 0 -10000 0 0
BCL2L11 0.035 0.039 -9999 0 -10000 0 0
FOXO1/SKP2 -0.021 0.19 -9999 0 -0.49 24 24
mol:GDP 0.01 0.025 -9999 0 -0.054 7 7
RAN 0.016 0.049 -9999 0 -0.72 1 1
GADD45A 0.1 0.11 -9999 0 -0.56 2 2
YWHAQ 0.017 0 -9999 0 -10000 0 0
FOXO1/14-3-3 family 0.09 0.039 -9999 0 -10000 0 0
MST1 -0.01 0.15 -9999 0 -0.71 10 10
CSNK1D 0.017 0 -9999 0 -10000 0 0
CSNK1E 0.014 0.049 -9999 0 -0.72 1 1
FOXO4/14-3-3 family 0.077 0.037 -9999 0 -10000 0 0
YWHAB 0.017 0 -9999 0 -10000 0 0
MAPK8 0.05 0.018 -9999 0 -10000 0 0
MAPK9 0.05 0.017 -9999 0 -10000 0 0
YWHAG 0.017 0 -9999 0 -10000 0 0
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
YWHAZ 0.017 0 -9999 0 -10000 0 0
SIRT1 0.014 0.023 -9999 0 -10000 0 0
SOD2 0.075 0.21 -9999 0 -0.66 6 6
RBL2 0.071 0.15 -9999 0 -10000 0 0
RAL/GDP 0.03 0.025 -9999 0 -10000 0 0
CHUK 0.023 0.02 -9999 0 -10000 0 0
Ran/GTP 0.015 0.038 -9999 0 -0.55 1 1
CSNK1G2 0.017 0 -9999 0 -10000 0 0
RAL/GTP 0.045 0.022 -9999 0 -10000 0 0
CSNK1G1 0.017 0 -9999 0 -10000 0 0
FASLG -0.11 0.46 -9999 0 -1.4 24 24
SKP2 -0.059 0.22 -9999 0 -0.72 23 23
USP7 0.016 0.043 -9999 0 -0.63 1 1
IKBKB 0.019 0.052 -9999 0 -0.7 1 1
CCNB1 -0.031 0.29 -9999 0 -0.83 9 9
FOXO1-3a-4/beta catenin -0.018 0.095 -9999 0 -0.43 1 1
proteasomal ubiquitin-dependent protein catabolic process -0.021 0.18 -9999 0 -0.49 24 24
CSNK1A1 0.017 0 -9999 0 -10000 0 0
SGK1 0.002 0.025 -9999 0 -0.058 8 8
CSNK1G3 0.017 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.028 0.034 -9999 0 -0.46 1 1
ZFAND5 0.13 0.053 -9999 0 -10000 0 0
SFN 0.011 0.061 -9999 0 -0.63 2 2
CDK2 -0.061 0.23 -9999 0 -0.72 25 25
FOXO3A/14-3-3 0.063 0.058 -9999 0 -10000 0 0
CREBBP 0.022 0.002 -9999 0 -10000 0 0
FBXO32 -0.044 0.41 -9999 0 -1.3 19 19
BCL6 0.065 0.18 -9999 0 -1.3 1 1
RALB 0.019 0.001 -9999 0 -10000 0 0
RALA 0.019 0.001 -9999 0 -10000 0 0
YWHAH 0.017 0 -9999 0 -10000 0 0
Regulation of p38-alpha and p38-beta

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0 0 -9999 0 -10000 0 0
response to insulin stimulus 0 0 -9999 0 -10000 0 0
RIPK1 0.017 0 -9999 0 -10000 0 0
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 -0.009 0.13 -9999 0 -0.63 9 9
mol:GTP 0 0 -9999 0 -10000 0 0
MAP2K4 0.005 0.086 -9999 0 -0.63 4 4
RAC1-CDC42/GTP/PAK family 0.037 0 -9999 0 -10000 0 0
response to UV 0 0 -9999 0 -10000 0 0
YES1 0.017 0 -9999 0 -10000 0 0
interleukin-1 receptor activity 0 0 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
MAP3K3 0.017 0 -9999 0 -10000 0 0
FYN 0.014 0.043 -9999 0 -0.63 1 1
MAP3K12 0.017 0 -9999 0 -10000 0 0
FGR 0.017 0 -9999 0 -10000 0 0
p38 alpha/TAB1 -0.035 0.065 -9999 0 -0.41 2 2
PRKG1 0.017 0 -9999 0 -10000 0 0
DUSP8 0.014 0.043 -9999 0 -0.63 1 1
PGK/cGMP/p38 alpha -0.034 0.063 -9999 0 -0.4 2 2
apoptosis -0.034 0.063 -9999 0 -0.39 2 2
RAL/GTP 0 0 -9999 0 -10000 0 0
LYN 0.017 0 -9999 0 -10000 0 0
DUSP1 -0.038 0.18 -9999 0 -0.63 19 19
PAK1 0.017 0 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0 0 -9999 0 -10000 0 0
TRAF6 0.017 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
mol:cGMP 0 0 -9999 0 -10000 0 0
CCM2 0.017 0 -9999 0 -10000 0 0
RAC1-CDC42/GTP 0 0 -9999 0 -10000 0 0
MAPK11 -0.001 0.14 -9999 0 -0.38 12 12
BLK -0.17 0.29 -9999 0 -0.63 63 63
HCK -0.044 0.19 -9999 0 -0.63 21 21
MAP2K3 0.017 0 -9999 0 -10000 0 0
DUSP16 0.017 0 -9999 0 -10000 0 0
DUSP10 -0.066 0.23 -9999 0 -0.72 25 25
TRAF6/MEKK3 0 0 -9999 0 -10000 0 0
MAP3K7IP1 0.017 0 -9999 0 -10000 0 0
MAPK14 0.011 0.11 -9999 0 -0.45 2 2
positive regulation of innate immune response 0.004 0.15 -9999 0 -0.52 3 3
LCK 0.011 0.065 -9999 0 -0.68 2 2
p38alpha-beta/MKP7 0.013 0.14 -9999 0 -0.55 2 2
p38alpha-beta/MKP5 -0.027 0.18 -9999 0 -0.5 12 12
PGK/cGMP 0 0 -9999 0 -10000 0 0
PAK2 0.017 0 -9999 0 -10000 0 0
p38alpha-beta/MKP1 -0.012 0.18 -9999 0 -0.57 6 6
CDC42 0.017 0 -9999 0 -10000 0 0
RALB 0.017 0 -9999 0 -10000 0 0
RALA 0.017 0 -9999 0 -10000 0 0
PAK3 0.017 0 -9999 0 -10000 0 0
IL2 signaling events mediated by STAT5

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.018 0 -9999 0 -10000 0 0
ELF1 0.015 0.072 -9999 0 -0.7 1 1
CCNA2 -0.092 0.26 -9999 0 -0.72 33 33
PIK3CA 0.018 0 -9999 0 -10000 0 0
JAK3 0.018 0 -9999 0 -10000 0 0
PIK3R1 0.018 0 -9999 0 -10000 0 0
JAK1 0.018 0 -9999 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.1 0.047 -9999 0 -10000 0 0
SHC1 0.018 0 -9999 0 -10000 0 0
SP1 0.007 0.081 -9999 0 -10000 0 0
IL2RA 0.02 0.12 -9999 0 -0.6 8 8
IL2RB 0.015 0.043 -9999 0 -0.63 1 1
SOS1 0.018 0 -9999 0 -10000 0 0
IL2RG 0.009 0.075 -9999 0 -0.63 3 3
G1/S transition of mitotic cell cycle -0.016 0.17 -9999 0 -0.67 6 6
PTPN11 0.015 0.049 -9999 0 -0.72 1 1
CCND2 -0.005 0.18 -9999 0 -0.7 14 14
LCK 0.012 0.065 -9999 0 -0.68 2 2
GRB2 0.018 0 -9999 0 -10000 0 0
IL2 0.018 0 -9999 0 -10000 0 0
CDK6 0.01 0.07 -9999 0 -0.72 2 2
CCND3 0.11 0.044 -9999 0 -10000 0 0
S1P3 pathway

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.017 0 -9999 0 -10000 0 0
mol:S1P 0.002 0 -9999 0 -10000 0 0
S1P1/S1P/Gi 0 0.12 -9999 0 -0.49 4 4
GNAO1 0.019 0 -9999 0 -10000 0 0
S1P/S1P3/G12/G13 0 0 -9999 0 -10000 0 0
AKT1 -0.008 0.023 -9999 0 -10000 0 0
AKT3 0.027 0.079 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB 0.017 0 -9999 0 -10000 0 0
GNAI2 0.019 0 -9999 0 -10000 0 0
GNAI3 0.019 0 -9999 0 -10000 0 0
GNAI1 -0.068 0.22 -9999 0 -0.63 30 30
mol:GDP 0 0 -9999 0 -10000 0 0
S1PR3 0.002 0 -9999 0 -10000 0 0
S1PR2 0 0 -9999 0 -10000 0 0
EDG1 -0.021 0.15 -9999 0 -0.63 13 13
mol:Ca2+ 0.019 0.088 -9999 0 -10000 0 0
MAPK3 0.026 0.089 -9999 0 -10000 0 0
MAPK1 0.028 0.086 -9999 0 -10000 0 0
JAK2 0.023 0.096 -9999 0 -0.38 1 1
CXCR4 0.009 0.12 -9999 0 -0.38 11 11
FLT1 -0.015 0.16 -9999 0 -0.72 11 11
RhoA/GDP 0 0 -9999 0 -10000 0 0
Rac1/GDP 0 0 -9999 0 -10000 0 0
SRC 0.029 0.084 -9999 0 -10000 0 0
S1P/S1P3/Gi 0.019 0.089 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
RhoA/GTP -0.024 0.06 -9999 0 -10000 0 0
VEGFA -0.048 0.22 -9999 0 -0.72 21 21
S1P/S1P2/Gi 0.014 0.088 -9999 0 -10000 0 0
VEGFR1 homodimer/VEGFA homodimer -0.042 0.22 -9999 0 -0.6 28 28
RHOA 0.017 0 -9999 0 -10000 0 0
S1P/S1P3/Gq -0.001 0.091 -9999 0 -0.3 14 14
GNAQ 0 0 -9999 0 -10000 0 0
GNAZ 0.019 0 -9999 0 -10000 0 0
G12/G13 0 0 -9999 0 -10000 0 0
GNA14 -0.009 0.13 -9999 0 -0.63 9 9
GNA15 -0.006 0.13 -9999 0 -0.72 7 7
GNA12 0.017 0 -9999 0 -10000 0 0
GNA13 0.017 0 -9999 0 -10000 0 0
GNA11 0 0.1 -9999 0 -0.63 6 6
Rac1/GTP -0.024 0.06 -9999 0 -10000 0 0
Angiopoietin receptor Tie2-mediated signaling

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.095 0.079 -9999 0 -10000 0 0
NCK1/PAK1/Dok-R -0.007 0.031 -9999 0 -10000 0 0
NCK1/Dok-R -0.01 0.055 -9999 0 -10000 0 0
PIK3CA 0.016 0 -9999 0 -10000 0 0
mol:beta2-estradiol -0.015 0.012 -9999 0 -10000 0 0
RELA 0.017 0 -9999 0 -10000 0 0
SHC1 0.018 0.001 -9999 0 -10000 0 0
Rac/GDP 0 0 -9999 0 -10000 0 0
F2 0.001 0.012 -9999 0 -10000 0 0
TNIP2 0.017 0 -9999 0 -10000 0 0
NF kappa B/RelA -0.006 0.045 -9999 0 -10000 0 0
FN1 -0.069 0.24 -9999 0 -0.72 26 26
PLD2 0.091 0.066 -9999 0 -10000 0 0
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
GRB14 -0.081 0.25 -9999 0 -0.69 31 31
ELK1 0.099 0.065 -9999 0 -10000 0 0
GRB7 -0.009 0.14 -9999 0 -0.72 8 8
PAK1 0.017 0 -9999 0 -10000 0 0
Tie2/Ang1/alpha5/beta1 Integrin -0.048 0.12 -9999 0 -10000 0 0
CDKN1A 0.052 0.14 -9999 0 -0.83 3 3
ITGA5 0 0.11 -9999 0 -0.72 5 5
mol:GTP 0 0 -9999 0 -10000 0 0
RasGAP/Dok-R -0.013 0.062 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
mol:NO 0.097 0.075 -9999 0 -10000 0 0
PLG 0.091 0.066 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
chemokinesis 0.092 0.071 -9999 0 -10000 0 0
GRB2 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.018 0.001 -9999 0 -10000 0 0
ANGPT2 -0.043 0.14 -9999 0 -10000 0 0
BMX -0.18 0.17 -9999 0 -0.73 3 3
ANGPT1 0.054 0.04 -9999 0 -10000 0 0
tube development 0.053 0.1 -9999 0 -10000 0 0
ANGPT4 0.018 0.001 -9999 0 -10000 0 0
response to hypoxia 0.007 0.008 -9999 0 -10000 0 0
Tie2/Ang1/GRB14 0.032 0.15 -9999 0 -10000 0 0
alpha5/beta1 Integrin -0.014 0.087 -9999 0 -0.54 6 6
FGF2 -0.011 0.13 -9999 0 -0.64 9 9
STAT5A (dimer) 0.058 0.12 -9999 0 -10000 0 0
mol:L-citrulline 0.097 0.075 -9999 0 -10000 0 0
AGTR1 -0.26 0.32 -9999 0 -0.63 96 96
MAPK14 0.08 0.066 -9999 0 -10000 0 0
Tie2/SHP2 -0.005 0.031 -9999 0 -10000 0 0
TEK 0.066 0.041 -9999 0 -10000 0 0
RPS6KB1 0.091 0.081 -9999 0 -10000 0 0
Angiotensin II/AT1 -0.19 0.24 -9999 0 -0.47 96 96
Tie2/Ang1/GRB2 0.087 0.065 -9999 0 -10000 0 0
MAPK3 0.094 0.071 -9999 0 -10000 0 0
MAPK1 0.096 0.067 -9999 0 -10000 0 0
Tie2/Ang1/GRB7 0.072 0.099 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
MAPK8 0.091 0.066 -9999 0 -10000 0 0
PI3K 0.086 0.078 -9999 0 -10000 0 0
FES 0.077 0.072 -9999 0 -10000 0 0
Crk/Dok-R -0.011 0.057 -9999 0 -10000 0 0
Tie2/Ang1/ABIN2 0.087 0.065 -9999 0 -10000 0 0
blood circulation 0 0 -9999 0 -10000 0 0
negative regulation of caspase activity 0.094 0.076 -9999 0 -10000 0 0
STAT5A 0.017 0.002 -9999 0 -10000 0 0
mol:ROS 0 0 -9999 0 -10000 0 0
PTK2 0.091 0.078 -9999 0 -10000 0 0
Tie2/Ang2 0.046 0.12 -9999 0 -10000 0 0
Tie2/Ang1 0.084 0.069 -9999 0 -10000 0 0
FOXO1 0.095 0.098 -9999 0 -10000 0 0
ELF1 0.026 0.049 -9999 0 -0.71 1 1
ELF2 0.084 0.076 -9999 0 -10000 0 0
mol:Choline 0.09 0.065 -9999 0 -10000 0 0
cell migration -0.015 0.037 -9999 0 -10000 0 0
FYN 0.053 0.11 -9999 0 -10000 0 0
DOK2 0.008 0.075 -9999 0 -0.63 3 3
negative regulation of cell cycle 0.052 0.13 -9999 0 -0.73 3 3
ETS1 0.031 0.011 -9999 0 -10000 0 0
PXN 0.097 0.073 -9999 0 -10000 0 0
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
NOS3 0.099 0.079 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
TNF 0.032 0.011 -9999 0 -10000 0 0
MAPKKK cascade 0.09 0.065 -9999 0 -10000 0 0
RASA1 0.01 0.07 -9999 0 -0.72 2 2
Tie2/Ang1/Shc 0.085 0.068 -9999 0 -10000 0 0
NCK1 0.017 0 -9999 0 -10000 0 0
vasculogenesis 0.095 0.072 -9999 0 -10000 0 0
mol:Phosphatidic acid 0.09 0.065 -9999 0 -10000 0 0
mol:Angiotensin II 0.002 0.002 -9999 0 -10000 0 0
mol:NADP 0.097 0.075 -9999 0 -10000 0 0
Rac1/GTP -0.009 0.039 -9999 0 -10000 0 0
MMP2 0.087 0.077 -9999 0 -10000 0 0
Nephrin/Neph1 signaling in the kidney podocyte

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity 0.005 0.05 0.53 2 -10000 0 2
KIRREL 0.018 0.005 -10000 0 -10000 0 0
Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.005 0.05 -10000 0 -0.53 2 2
PLCG1 -0.033 0.18 -10000 0 -0.72 15 15
ARRB2 0.017 0 -10000 0 -10000 0 0
WASL 0.014 0.043 -10000 0 -0.63 1 1
Nephrin/NEPH1/podocin/CD2AP -0.004 0.036 -10000 0 -10000 0 0
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.048 0.032 -10000 0 -10000 0 0
FYN 0.032 0.041 -10000 0 -10000 0 0
mol:Ca2+ -0.033 0.12 -10000 0 -0.46 15 15
mol:DAG -0.033 0.12 -10000 0 -0.46 15 15
NPHS2 0.018 0.005 -10000 0 -10000 0 0
mol:IP3 -0.033 0.12 -10000 0 -0.46 15 15
regulation of endocytosis -0.004 0.033 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/Cholesterol -0.004 0.037 -10000 0 -0.39 2 2
establishment of cell polarity -0.005 0.05 -10000 0 -0.53 2 2
Nephrin/NEPH1/podocin/NCK1-2 -0.003 0.032 -10000 0 -10000 0 0
Nephrin/NEPH1/beta Arrestin2 -0.004 0.034 -10000 0 -10000 0 0
NPHS1 0.012 0.069 -10000 0 -0.71 2 2
Nephrin/NEPH1/podocin -0.004 0.037 -10000 0 -10000 0 0
TJP1 0.017 0 -10000 0 -10000 0 0
NCK1 0.017 0 -10000 0 -10000 0 0
NCK2 0.017 0 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 -0.033 0.12 -10000 0 -0.47 15 15
CD2AP 0.017 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/GRB2 -0.004 0.036 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 0.035 0.051 -10000 0 -10000 0 0
cytoskeleton organization 0.059 0.036 -10000 0 -10000 0 0
Nephrin/NEPH1 -0.004 0.036 -10000 0 -0.39 2 2
Nephrin/NEPH1/ZO-1 -0.004 0.04 -10000 0 -0.42 2 2
Circadian rhythm pathway

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification -0.055 0.14 -10000 0 -0.83 1 1
CLOCK 0.021 0.005 -10000 0 -10000 0 0
TIMELESS/CRY2 0.048 0.076 -10000 0 -10000 0 0
DEC1/BMAL1 -0.002 0.036 -10000 0 -0.54 1 1
ATR 0.014 0.049 -10000 0 -0.72 1 1
NR1D1 0.05 0.066 -10000 0 -0.54 2 2
ARNTL 0.021 0.005 -10000 0 -10000 0 0
TIMELESS 0.047 0.083 -10000 0 -0.54 4 4
NPAS2 0.021 0.005 -10000 0 -10000 0 0
CRY2 0.017 0 -10000 0 -10000 0 0
mol:CO -0.016 0.019 0.096 6 -10000 0 6
CHEK1 -0.075 0.24 -10000 0 -0.72 28 28
mol:HEME 0.016 0.019 -10000 0 -0.096 6 6
PER1 0.017 0 -10000 0 -10000 0 0
BMAL/CLOCK/NPAS2 0.055 0.018 -10000 0 -10000 0 0
BMAL1/CLOCK 0.066 0.064 -10000 0 -10000 0 0
S phase of mitotic cell cycle -0.055 0.14 -10000 0 -0.83 1 1
TIMELESS/CHEK1/ATR -0.056 0.14 -10000 0 -0.85 1 1
mol:NADPH 0.016 0.019 -10000 0 -0.096 6 6
PER1/TIMELESS 0.048 0.076 -10000 0 -10000 0 0
PER1-2 / CRY1-2 0 0 -10000 0 -10000 0 0
DEC1 0.014 0.049 -10000 0 -0.72 1 1
Ephrin A reverse signaling

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade -0.006 0.051 -9999 0 -0.44 3 3
EFNA5 0.014 0.043 -9999 0 -0.63 1 1
FYN 0.027 0.056 -9999 0 -0.38 4 4
neuron projection morphogenesis -0.006 0.051 -9999 0 -0.44 3 3
cell-cell signaling 0 0 -9999 0 -10000 0 0
Ephrin A5/EPHA5 -0.006 0.051 -9999 0 -0.44 3 3
EPHA5 0.01 0.07 -9999 0 -0.72 2 2
JNK signaling in the CD4+ TCR pathway

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 -0.011 0.064 -9999 0 -10000 0 0
MAP4K1 0.017 0 -9999 0 -10000 0 0
MAP3K8 -0.089 0.26 -9999 0 -0.72 32 32
PRKCB 0 0 -9999 0 -10000 0 0
DBNL 0.017 0 -9999 0 -10000 0 0
CRKL 0.017 0 -9999 0 -10000 0 0
MAP3K1 0.056 0.041 -9999 0 -10000 0 0
JUN 0.026 0.064 -9999 0 -0.38 5 5
MAP3K7 0.056 0.041 -9999 0 -10000 0 0
GRAP2 0.017 0 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
MAP2K4 0.044 0.069 -9999 0 -10000 0 0
LAT 0.01 0.07 -9999 0 -0.72 2 2
LCP2 0.004 0.095 -9999 0 -0.7 4 4
MAPK8 0.027 0.021 -9999 0 -10000 0 0
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.047 0.044 -9999 0 -10000 0 0
LAT/GRAP2/SLP76/HPK1/HIP-55 -0.01 0.059 -9999 0 -10000 0 0
Hedgehog signaling events mediated by Gli proteins

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0.001 -9999 0 -10000 0 0
HDAC2 0.017 0.001 -9999 0 -10000 0 0
GNB1/GNG2 -0.008 0.059 -9999 0 -0.46 3 3
forebrain development -0.007 0.17 -9999 0 -0.67 7 7
GNAO1 0.015 0.007 -9999 0 -10000 0 0
SMO/beta Arrestin2 0.014 0.074 -9999 0 -0.52 4 4
SMO 0.002 0.096 -9999 0 -0.7 4 4
ARRB2 0.014 0.008 -9999 0 -10000 0 0
GLI3/SPOP 0.03 0.097 -9999 0 -0.4 2 2
mol:GTP 0 0.003 -9999 0 -10000 0 0
GSK3B 0.014 0.049 -9999 0 -0.72 1 1
GNAI2 0.015 0.007 -9999 0 -10000 0 0
SIN3/HDAC complex -0.002 0.027 -9999 0 -10000 0 0
GNAI1 -0.072 0.22 -9999 0 -0.63 30 30
XPO1 0.017 0.009 -9999 0 -10000 0 0
GLI1/Su(fu) -0.051 0.11 -9999 0 -0.63 4 4
SAP30 0.017 0.001 -9999 0 -10000 0 0
mol:GDP 0.002 0.096 -9999 0 -0.7 4 4
MIM/GLI2A 0.007 0.097 -9999 0 -0.63 5 5
IFT88 -0.003 0.12 -9999 0 -0.72 6 6
GNAI3 0.014 0.007 -9999 0 -10000 0 0
GLI2 0.057 0.033 -9999 0 -10000 0 0
GLI3 0.022 0.1 -9999 0 -0.43 2 2
CSNK1D 0.017 0 -9999 0 -10000 0 0
CSNK1E 0.014 0.049 -9999 0 -0.72 1 1
SAP18 0.014 0.049 -9999 0 -0.72 1 1
embryonic digit morphogenesis -0.003 0.12 -9999 0 -0.72 6 6
GNG2 0.017 0 -9999 0 -10000 0 0
Gi family/GTP 0.005 0.098 -9999 0 -10000 0 0
SIN3B 0.017 0.001 -9999 0 -10000 0 0
SIN3A 0.017 0.001 -9999 0 -10000 0 0
GLI3/Su(fu) 0.037 0.084 -9999 0 -10000 0 0
GLI2/Su(fu) 0.059 0.053 -9999 0 -10000 0 0
FOXA2 -0.15 0.27 -9999 0 -0.7 19 19
neural tube patterning -0.007 0.17 -9999 0 -0.67 7 7
SPOP 0.017 0 -9999 0 -10000 0 0
Su(fu)/PIAS1 0.031 0.04 -9999 0 -10000 0 0
GNB1 0.017 0 -9999 0 -10000 0 0
CSNK1G2 0.017 0 -9999 0 -10000 0 0
CSNK1G3 0.017 0 -9999 0 -10000 0 0
MTSS1 0.007 0.097 -9999 0 -0.63 5 5
embryonic limb morphogenesis -0.007 0.17 -9999 0 -0.67 7 7
SUFU 0.027 0.044 -9999 0 -10000 0 0
LGALS3 -0.003 0.11 -9999 0 -0.63 7 7
catabolic process 0.065 0.092 -9999 0 -10000 0 0
GLI3A/CBP 0.002 0.087 -9999 0 -10000 0 0
KIF3A 0.014 0.049 -9999 0 -0.72 1 1
GLI1 -0.007 0.17 -9999 0 -0.69 7 7
RAB23 -0.009 0.14 -9999 0 -0.72 8 8
CSNK1A1 0.017 0 -9999 0 -10000 0 0
IFT172 0.014 0.043 -9999 0 -0.63 1 1
RBBP7 0.017 0.001 -9999 0 -10000 0 0
Su(fu)/Galectin3 0.019 0.075 -9999 0 -10000 0 0
GNAZ 0.014 0.007 -9999 0 -10000 0 0
RBBP4 0.017 0.001 -9999 0 -10000 0 0
CSNK1G1 0.017 0 -9999 0 -10000 0 0
PIAS1 0.017 0 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
GLI2/SPOP 0.062 0.031 -9999 0 -10000 0 0
STK36 0.013 0.05 -9999 0 -0.72 1 1
Gi family/GNB1/GNG2/GDP 0.013 0.092 -9999 0 -10000 0 0
PTCH1 0.006 0.15 -9999 0 -0.71 3 3
MIM/GLI1 -0.042 0.23 -9999 0 -0.8 7 7
CREBBP 0.002 0.087 -9999 0 -10000 0 0
Su(fu)/SIN3/HDAC complex 0.067 0.017 -9999 0 -10000 0 0
Arf6 downstream pathway

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.052 0.053 -10000 0 -0.55 1 1
regulation of axonogenesis -0.014 0.081 -10000 0 -10000 0 0
myoblast fusion 0.002 0.02 0.26 1 -10000 0 1
mol:GTP 0 0.013 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.036 0.067 0.4 5 -10000 0 5
ARF1/GTP 0 0.01 -10000 0 -10000 0 0
mol:GM1 0.015 0.01 -10000 0 -10000 0 0
mol:Choline -0.002 0.12 -10000 0 -0.37 23 23
lamellipodium assembly 0.001 0.027 -10000 0 -10000 0 0
MAPK3 0.035 0.047 -10000 0 -0.42 2 2
ARF6/GTP/NME1/Tiam1 0.037 0.068 -10000 0 -0.4 5 5
ARF1 0.017 0 -10000 0 -10000 0 0
ARF6/GDP -0.002 0.02 -10000 0 -0.27 1 1
ARF1/GDP 0.036 0.023 -10000 0 -10000 0 0
ARF6 0.016 0.007 -10000 0 -10000 0 0
RAB11A 0.017 0 -10000 0 -10000 0 0
TIAM1 0.013 0.061 -10000 0 -0.63 2 2
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.037 0.036 -10000 0 -0.42 1 1
actin filament bundle formation 0.002 0.017 -10000 0 -10000 0 0
KALRN 0.001 0.02 -10000 0 -10000 0 0
RAB11FIP3/RAB11A 0 0 -10000 0 -10000 0 0
RhoA/GDP -0.002 0.017 -10000 0 -10000 0 0
NME1 0.009 0.085 -10000 0 -0.72 3 3
Rac1/GDP -0.002 0.017 -10000 0 -10000 0 0
substrate adhesion-dependent cell spreading 0 0.013 -10000 0 -10000 0 0
cortical actin cytoskeleton organization 0.001 0.027 -10000 0 -10000 0 0
RAC1 0.017 0 -10000 0 -10000 0 0
liver development 0 0.013 -10000 0 -10000 0 0
ARF6/GTP 0 0.013 -10000 0 -10000 0 0
RhoA/GTP 0 0.01 -10000 0 -10000 0 0
mol:GDP 0 0.026 -10000 0 -10000 0 0
ARF6/GTP/RAB11FIP3/RAB11A 0 0.009 -10000 0 -10000 0 0
RHOA 0.017 0 -10000 0 -10000 0 0
PLD1 -0.018 0.14 -10000 0 -0.43 23 23
RAB11FIP3 0.017 0 -10000 0 -10000 0 0
tube morphogenesis 0.001 0.027 -10000 0 -10000 0 0
ruffle organization 0.014 0.081 -10000 0 -10000 0 0
regulation of epithelial cell migration 0 0.013 -10000 0 -10000 0 0
PLD2 0.029 0.009 -10000 0 -10000 0 0
PIP5K1A 0.014 0.081 -10000 0 -10000 0 0
mol:Phosphatidic acid -0.002 0.12 -10000 0 -0.37 23 23
Rac1/GTP 0.001 0.027 -10000 0 -10000 0 0
Paxillin-independent events mediated by a4b1 and a4b7

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.021 0.087 -9999 0 -0.42 2 2
CRKL 0.017 0 -9999 0 -10000 0 0
Rac1/GDP 0 0 -9999 0 -10000 0 0
DOCK1 0.011 0.061 -9999 0 -0.63 2 2
ITGA4 0.011 0.061 -9999 0 -0.63 2 2
alpha4/beta7 Integrin/MAdCAM1 -0.094 0.17 -9999 0 -0.69 6 6
EPO 0.014 0.049 -9999 0 -0.72 1 1
alpha4/beta7 Integrin -0.023 0.099 -9999 0 -0.46 11 11
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
alpha4/beta1 Integrin -0.007 0.056 -9999 0 -0.49 3 3
EPO/EPOR (dimer) -0.002 0.036 -9999 0 -0.54 1 1
lamellipodium assembly 0.001 0.008 -9999 0 -10000 0 0
PIK3CA 0.017 0 -9999 0 -10000 0 0
PI3K 0 0 -9999 0 -10000 0 0
ARF6 0.017 0 -9999 0 -10000 0 0
JAK2 -0.01 0.054 -9999 0 -10000 0 0
PXN 0.017 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
MADCAM1 -0.13 0.27 -9999 0 -0.63 51 51
cell adhesion -0.094 0.17 -9999 0 -0.68 6 6
CRKL/CBL 0 0 -9999 0 -10000 0 0
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
SRC 0.032 0.08 -9999 0 -0.69 1 1
ITGB7 -0.009 0.13 -9999 0 -0.63 9 9
RAC1 0.017 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 -0.014 0.081 -9999 0 -0.6 2 2
p130Cas/Crk/Dock1 -0.013 0.065 -9999 0 -0.57 1 1
VCAM1 0.002 0.096 -9999 0 -0.63 5 5
RHOA 0.017 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 -0.005 0.042 -9999 0 -0.41 1 1
BCAR1 0.043 0.076 -9999 0 -0.64 1 1
EPOR 0.017 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
CBL 0.017 0 -9999 0 -10000 0 0
GIT1 0.017 0 -9999 0 -10000 0 0
Rac1/GTP 0.001 0.008 -9999 0 -10000 0 0
Retinoic acid receptors-mediated signaling

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0 -10000 0 -10000 0 0
HDAC3 0.017 0 -10000 0 -10000 0 0
VDR 0 0.1 -10000 0 -0.63 6 6
Cbp/p300/PCAF 0 0 -10000 0 -10000 0 0
EP300 0.017 0 -10000 0 -10000 0 0
RARs/AIB1/Cbp/p300/PCAF/9cRA 0.052 0.031 -10000 0 -10000 0 0
KAT2B 0 0 -10000 0 -10000 0 0
MAPK14 0.017 0 -10000 0 -10000 0 0
AKT1 0.055 0.06 0.24 9 -10000 0 9
RAR alpha/9cRA/Cyclin H -0.011 0.038 -10000 0 -10000 0 0
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA 0.049 0.033 -10000 0 -10000 0 0
CDC2 -0.051 0.22 -10000 0 -0.72 21 21
response to UV 0.002 0 -10000 0 -10000 0 0
RAR alpha/Jnk1 -0.004 0.024 -10000 0 -10000 0 0
NCOR2 0.017 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 -0.013 0.076 -10000 0 -0.47 6 6
RXRs/RARs/NRIP1/9cRA 0.077 0.062 -10000 0 -10000 0 0
NCOA2 0.017 0 -10000 0 -10000 0 0
NCOA3 0.004 0.098 -10000 0 -0.72 4 4
NCOA1 0.011 0.061 -10000 0 -0.63 2 2
VDR/VDR/DNA 0 0.1 -10000 0 -0.63 6 6
RARG 0.012 0.07 -10000 0 -0.72 2 2
RAR gamma1/9cRA -0.004 0.044 -10000 0 -0.47 2 2
MAPK3 0.012 0.061 -10000 0 -0.63 2 2
MAPK1 0.014 0.043 -10000 0 -0.63 1 1
MAPK8 0.019 0 -10000 0 -10000 0 0
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 -0.021 0.067 -10000 0 -0.4 2 2
RARA 0.037 0.037 -10000 0 -10000 0 0
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA 0.051 0.023 -10000 0 -10000 0 0
PRKCA 0.019 0.049 -10000 0 -0.72 1 1
RXRs/RARs/NRIP1/9cRA/HDAC1 0.069 0.052 -10000 0 -10000 0 0
RXRG 0.035 0.05 -10000 0 -10000 0 0
RXRA 0.033 0.079 -10000 0 -0.41 2 2
RXRB 0.034 0.05 -10000 0 -0.3 1 1
VDR/Vit D3/DNA -0.013 0.076 -10000 0 -0.47 6 6
RBP1 -0.068 0.23 -10000 0 -0.69 27 27
CRBP1/9-cic-RA -0.063 0.17 -10000 0 -0.52 27 27
RARB 0.021 0 -10000 0 -10000 0 0
PRKCG 0.009 0.098 -10000 0 -0.72 4 4
MNAT1 0.017 0 -10000 0 -10000 0 0
RAR alpha/RXRs 0.079 0.078 -10000 0 -10000 0 0
RXRs/RARs/SMRT(N-CoR2)/9cRA 0.076 0.059 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.057 0.035 -10000 0 -10000 0 0
RXRs/RARs/NRIP1/9cRA/HDAC3 0.069 0.052 -10000 0 -10000 0 0
positive regulation of DNA binding -0.011 0.037 -10000 0 -10000 0 0
NRIP1 0.069 0.046 -10000 0 -10000 0 0
RXRs/RARs 0.061 0.05 -10000 0 -10000 0 0
RXRs/RXRs/DNA/9cRA -0.015 0.051 -10000 0 -0.38 1 1
PRKACA 0.017 0 -10000 0 -10000 0 0
CDK7 0.017 0 -10000 0 -10000 0 0
TFIIH 0 0 -10000 0 -10000 0 0
RAR alpha/9cRA -0.002 0.014 -10000 0 -10000 0 0
CCNH 0.017 0 -10000 0 -10000 0 0
CREBBP 0.017 0 -10000 0 -10000 0 0
RAR gamma2/9cRA -0.003 0.032 -10000 0 -10000 0 0
LPA receptor mediated events

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.002 0.021 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha -0.005 0.016 -9999 0 -10000 0 0
AP1 -0.059 0.13 -9999 0 -0.34 37 37
mol:PIP3 -0.012 0.061 -9999 0 -0.47 1 1
AKT1 0.056 0.038 -9999 0 -10000 0 0
PTK2B 0.018 0.02 -9999 0 -10000 0 0
RHOA -0.002 0.023 -9999 0 -10000 0 0
PIK3CB 0.013 0.049 -9999 0 -0.72 1 1
mol:Ca2+ 0.017 0.042 -9999 0 -10000 0 0
MAGI3 0.011 0.061 -9999 0 -0.63 2 2
RELA 0.017 0 -9999 0 -10000 0 0
apoptosis 0.015 0.032 -9999 0 -0.26 3 3
HRAS/GDP 0 0 -9999 0 -10000 0 0
positive regulation of microtubule depolymerization 0.035 0.031 -9999 0 -0.34 1 1
NF kappa B1 p50/RelA -0.009 0.027 -9999 0 -10000 0 0
endothelial cell migration 0.019 0.065 -9999 0 -0.67 2 2
ADCY4 0.021 0.073 -9999 0 -0.33 1 1
ADCY5 0.022 0.071 -9999 0 -10000 0 0
ADCY6 0.022 0.071 -9999 0 -10000 0 0
ADCY7 0.022 0.071 -9999 0 -10000 0 0
ADCY1 0.022 0.071 -9999 0 -10000 0 0
ADCY2 0.021 0.071 -9999 0 -10000 0 0
ADCY3 0.014 0.078 -9999 0 -0.27 2 2
ADCY8 0.021 0.071 -9999 0 -10000 0 0
ADCY9 0.019 0.073 -9999 0 -10000 0 0
GSK3B 0.026 0.033 -9999 0 -0.38 1 1
arachidonic acid secretion 0.03 0.065 -9999 0 -10000 0 0
GNG2 0.017 0 -9999 0 -10000 0 0
TRIP6 0.013 0.066 -9999 0 -0.33 8 8
GNAO1 0.022 0.027 -9999 0 -0.26 2 2
HRAS 0.017 0 -9999 0 -10000 0 0
NFKBIA 0.03 0.035 -9999 0 -10000 0 0
GAB1 0.011 0.061 -9999 0 -0.63 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
lamellipodium assembly -0.008 0.088 -9999 0 -0.94 2 2
JUN 0 0.11 -9999 0 -0.72 5 5
LPA/LPA2/NHERF2 -0.001 0.008 -9999 0 -10000 0 0
TIAM1 -0.009 0.1 -9999 0 -1.1 2 2
PIK3R1 0.017 0 -9999 0 -10000 0 0
mol:IP3 0.017 0.043 -9999 0 -10000 0 0
PLCB3 0.024 0.009 -9999 0 -10000 0 0
FOS -0.08 0.23 -9999 0 -0.64 33 33
positive regulation of mitosis 0.03 0.065 -9999 0 -10000 0 0
LPA/LPA1-2-3 -0.002 0.024 -9999 0 -0.25 2 2
mol:Ca ++ 0 0 -9999 0 -10000 0 0
JNK cascade -0.001 0.001 -9999 0 -10000 0 0
BCAR1 0.017 0 -9999 0 -10000 0 0
stress fiber formation 0.026 0.022 -9999 0 -10000 0 0
GNAZ 0.022 0.027 -9999 0 -0.26 2 2
EGFR/PI3K-beta/Gab1 -0.012 0.063 -9999 0 -0.49 1 1
positive regulation of dendritic cell cytokine production -0.002 0.024 -9999 0 -0.25 2 2
LPA/LPA2/MAGI-3 -0.004 0.039 -9999 0 -0.4 2 2
ARHGEF1 0.04 0.023 -9999 0 -10000 0 0
GNAI2 0.022 0.027 -9999 0 -0.26 2 2
GNAI3 0.022 0.027 -9999 0 -0.26 2 2
GNAI1 -0.034 0.14 -9999 0 -0.39 32 32
LPA/LPA3 -0.001 0.012 -9999 0 -0.12 2 2
LPA/LPA2 -0.001 0.012 -9999 0 -0.12 2 2
LPA/LPA1 -0.003 0.031 -9999 0 -0.33 2 2
HB-EGF/EGFR -0.026 0.12 -9999 0 -0.51 9 9
HBEGF 0.004 0.12 -9999 0 -0.58 9 9
mol:DAG 0.017 0.043 -9999 0 -10000 0 0
cAMP biosynthetic process 0.028 0.072 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
GNB1 0.017 0 -9999 0 -10000 0 0
LYN 0.03 0.035 -9999 0 -10000 0 0
GNAQ 0 0.009 -9999 0 -0.091 2 2
LPAR2 -0.002 0.001 -9999 0 -10000 0 0
LPAR3 -0.002 0.001 -9999 0 -10000 0 0
LPAR1 0.004 0.018 -9999 0 -0.19 2 2
IL8 -0.32 0.12 -9999 0 -0.44 47 47
PTK2 0.014 0.037 -9999 0 -0.29 3 3
Rac1/GDP 0 0 -9999 0 -10000 0 0
CASP3 0.015 0.032 -9999 0 -0.26 3 3
EGFR 0 0.099 -9999 0 -0.65 5 5
PLCG1 -0.017 0.042 -9999 0 -0.26 2 2
PLD2 0.016 0.023 -9999 0 -0.22 2 2
G12/G13 -0.002 0.021 -9999 0 -10000 0 0
PI3K-beta -0.003 0.026 -9999 0 -10000 0 0
cell migration -0.002 0.032 -9999 0 -0.27 2 2
SLC9A3R2 0.017 0 -9999 0 -10000 0 0
PXN 0.026 0.022 -9999 0 -10000 0 0
HRAS/GTP -0.019 0.046 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
MMP9 -0.007 0.13 -9999 0 -0.71 7 7
PRKCE 0.017 0.002 -9999 0 -10000 0 0
PRKCD 0.024 0.041 -9999 0 -10000 0 0
Gi(beta/gamma) -0.021 0.051 -9999 0 -10000 0 0
mol:LPA -0.001 0.018 -9999 0 -0.19 2 2
TRIP6/p130 Cas/FAK1/Paxillin -0.004 0.045 -9999 0 -10000 0 0
MAPKKK cascade 0.03 0.065 -9999 0 -10000 0 0
contractile ring contraction involved in cytokinesis 0.029 0.025 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
GNA14 -0.003 0.071 -9999 0 -0.34 9 9
GNA15 0 0.061 -9999 0 -0.34 7 7
GNA12 0.017 0 -9999 0 -10000 0 0
GNA13 0.017 0 -9999 0 -10000 0 0
MAPT 0.035 0.031 -9999 0 -0.35 1 1
GNA11 0.002 0.058 -9999 0 -0.35 6 6
Rac1/GTP -0.008 0.094 -9999 0 -1 2 2
MMP2 0.019 0.066 -9999 0 -0.67 2 2
E-cadherin signaling in the nascent adherens junction

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.027 0.098 -9999 0 -0.48 6 6
KLHL20 -0.035 0.068 -9999 0 -0.28 2 2
CYFIP2 0.011 0.061 -9999 0 -0.63 2 2
Rac1/GDP 0.06 0.072 -9999 0 -10000 0 0
ENAH 0.023 0.1 -9999 0 -0.48 6 6
AP1M1 0.017 0 -9999 0 -10000 0 0
RAP1B 0.017 0 -9999 0 -10000 0 0
RAP1A 0.017 0 -9999 0 -10000 0 0
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
CDC42/GTP -0.011 0.044 -9999 0 -10000 0 0
ABI1/Sra1/Nap1 -0.024 0.047 -9999 0 -0.22 3 3
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.034 0.1 -9999 0 -10000 0 0
RAPGEF1 0.051 0.089 -9999 0 -10000 0 0
CTNND1 0.017 0 -9999 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.02 0.09 -9999 0 -0.5 6 6
CRK 0.042 0.095 -9999 0 -0.44 6 6
E-cadherin/gamma catenin/alpha catenin -0.01 0.062 -9999 0 -10000 0 0
alphaE/beta7 Integrin -0.018 0.09 -9999 0 -0.46 9 9
IQGAP1 0.017 0 -9999 0 -10000 0 0
NCKAP1 0.014 0.049 -9999 0 -0.72 1 1
Rap1/GTP/I-afadin 0 0 -9999 0 -10000 0 0
DLG1 0.027 0.098 -9999 0 -0.48 6 6
ChemicalAbstracts:7440-70-2 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.008 0.032 -9999 0 -10000 0 0
MLLT4 0.017 0 -9999 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 -0.009 0.058 -9999 0 -0.42 3 3
PI3K -0.01 0.04 -9999 0 -10000 0 0
ARF6 0.017 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
E-cadherin/gamma catenin -0.012 0.074 -9999 0 -0.46 6 6
TIAM1 0.011 0.061 -9999 0 -0.63 2 2
E-cadherin(dimer)/Ca2+ -0.019 0.08 -9999 0 -10000 0 0
AKT1 -0.006 0.022 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
CDH1 -0.001 0.1 -9999 0 -0.63 6 6
RhoA/GDP 0.061 0.072 -9999 0 -10000 0 0
actin cytoskeleton organization -0.026 0.05 -9999 0 -0.2 2 2
CDC42/GDP 0.061 0.072 -9999 0 -10000 0 0
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.026 0.049 -9999 0 -10000 0 0
ITGB7 -0.009 0.13 -9999 0 -0.63 9 9
RAC1 0.017 0 -9999 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin -0.02 0.085 -9999 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin -0.019 0.082 -9999 0 -0.4 6 6
mol:GDP 0.056 0.081 -9999 0 -10000 0 0
CDC42/GTP/IQGAP1 0 0 -9999 0 -10000 0 0
JUP 0.017 0 -9999 0 -10000 0 0
p120 catenin/RhoA/GDP -0.013 0.052 -9999 0 -10000 0 0
RAC1/GTP/IQGAP1 0 0 -9999 0 -10000 0 0
PIP5K1C/AP1M1 0 0 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
CDC42 0.017 0 -9999 0 -10000 0 0
CTNNA1 0.017 0 -9999 0 -10000 0 0
positive regulation of S phase of mitotic cell cycle -0.001 0.11 -9999 0 -0.24 35 35
NME1 0.007 0.085 -9999 0 -0.72 3 3
clathrin coat assembly 0 0 -9999 0 -10000 0 0
TJP1 0.027 0.098 -9999 0 -0.48 6 6
regulation of cell-cell adhesion -0.01 0.039 -9999 0 -10000 0 0
WASF2 -0.013 0.027 -9999 0 -0.2 1 1
Rap1/GTP -0.013 0.051 -9999 0 -10000 0 0
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.021 0.077 -9999 0 -10000 0 0
CCND1 -0.005 0.13 -9999 0 -0.3 35 35
VAV2 0.032 0.13 -9999 0 -0.7 4 4
RAP1/GDP -0.003 0.056 -9999 0 -10000 0 0
adherens junction assembly 0.035 0.095 -9999 0 -0.46 6 6
homophilic cell adhesion 0 0 -9999 0 -10000 0 0
ABI1 0.017 0 -9999 0 -10000 0 0
PIP5K1C 0.017 0 -9999 0 -10000 0 0
regulation of heterotypic cell-cell adhesion -0.029 0.09 -9999 0 -10000 0 0
E-cadherin/beta catenin -0.013 0.066 -9999 0 -0.4 6 6
mol:GTP 0 0 -9999 0 -10000 0 0
SRC 0.028 0.098 -9999 0 -0.48 6 6
PIK3CA 0.017 0 -9999 0 -10000 0 0
Rac1/GTP -0.057 0.11 -9999 0 -0.49 2 2
E-cadherin/beta catenin/alpha catenin -0.023 0.095 -9999 0 -0.46 6 6
ITGAE 0.017 0 -9999 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.021 0.092 -9999 0 -0.51 6 6
Arf6 trafficking events

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 -0.17 0.3 -10000 0 -0.63 66 66
CLTC 0.034 0.037 -10000 0 -10000 0 0
calcium ion-dependent exocytosis 0.017 0.057 -10000 0 -10000 0 0
Dynamin 2/GTP -0.006 0.048 -10000 0 -0.42 3 3
EXOC4 0.017 0 -10000 0 -10000 0 0
CD59 0.029 0.034 -10000 0 -10000 0 0
CPE -0.019 0.13 -10000 0 -0.41 23 23
CTNNB1 -0.003 0.12 -10000 0 -0.72 6 6
membrane fusion -0.017 0.049 -10000 0 -10000 0 0
CTNND1 0.038 0.049 -10000 0 -10000 0 0
DNM2 0.017 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.033 0.035 -10000 0 -10000 0 0
TSHR 0.026 0 -10000 0 -10000 0 0
INS 0.023 0.012 -10000 0 -10000 0 0
BIN1 0.017 0 -10000 0 -10000 0 0
mol:Choline -0.017 0.049 -10000 0 -10000 0 0
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.019 0.057 -10000 0 -0.47 3 3
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.017 0 -10000 0 -10000 0 0
mol:Ca2+ -0.006 0.048 -10000 0 -0.42 3 3
JUP 0.029 0.034 -10000 0 -10000 0 0
ASAP2/amphiphysin II 0 0 -10000 0 -10000 0 0
ARF6/GTP 0 0 -10000 0 -10000 0 0
CDH1 0.022 0.062 -10000 0 -0.56 1 1
clathrin-independent pinocytosis 0 0 -10000 0 -10000 0 0
MAPK8IP3 0.017 0 -10000 0 -10000 0 0
positive regulation of endocytosis 0 0 -10000 0 -10000 0 0
EXOC2 0.017 0 -10000 0 -10000 0 0
substrate adhesion-dependent cell spreading 0.059 0 -10000 0 -10000 0 0
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.017 0 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion 0.015 0.081 0.61 2 -10000 0 2
positive regulation of phagocytosis 0.025 0 -10000 0 -10000 0 0
ARF6/GTP/JIP3 0 0 -10000 0 -10000 0 0
ACAP1 0.016 0.048 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 0.009 0.074 -10000 0 -10000 0 0
clathrin heavy chain/ACAP1 0.036 0.047 -10000 0 -10000 0 0
JIP4/KLC1 0 0 -10000 0 -10000 0 0
EXOC1 0.017 0 -10000 0 -10000 0 0
exocyst 0.059 0 -10000 0 -10000 0 0
RALA/GTP 0 0 -10000 0 -10000 0 0
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0 0 -10000 0 -10000 0 0
receptor recycling 0 0 -10000 0 -10000 0 0
CTNNA1 0.038 0.049 -10000 0 -10000 0 0
NME1 0.019 0.057 -10000 0 -0.47 3 3
clathrin coat assembly 0.034 0.037 -10000 0 -10000 0 0
IL2RA 0.022 0.051 -10000 0 -10000 0 0
VAMP3 0.026 0 -10000 0 -10000 0 0
GLUT4/clathrin heavy chain/ACAP1 -0.088 0.13 -10000 0 -0.45 4 4
EXOC6 0.017 0 -10000 0 -10000 0 0
PLD1 -0.03 0.088 -10000 0 -0.29 23 23
PLD2 0 0 -10000 0 -10000 0 0
EXOC5 0.017 0 -10000 0 -10000 0 0
PIP5K1C 0.033 0.035 -10000 0 -10000 0 0
SDC1 0.029 0.034 -10000 0 -10000 0 0
ARF6/GDP 0.018 0.056 -10000 0 -0.47 3 3
EXOC7 0.017 0 -10000 0 -10000 0 0
E-cadherin/beta catenin -0.016 0.084 -10000 0 -0.64 2 2
mol:Phosphatidic acid -0.017 0.049 -10000 0 -10000 0 0
endocytosis 0 0 -10000 0 -10000 0 0
SCAMP2 0.017 0 -10000 0 -10000 0 0
ADRB2 -0.081 0.17 -10000 0 -10000 0 0
EXOC3 0.017 0 -10000 0 -10000 0 0
ASAP2 0 0 -10000 0 -10000 0 0
Dynamin 2/GDP 0.028 0.052 -10000 0 -0.42 3 3
KLC1 0.017 0 -10000 0 -10000 0 0
AVPR2 0.044 0.035 -10000 0 -10000 0 0
RALA 0.017 0 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.076 -10000 0 -0.58 2 2
Insulin Pathway

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP -0.03 0.1 -9999 0 -0.64 3 3
TC10/GTP -0.021 0.075 -9999 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/Shp2 -0.013 0.071 -9999 0 -0.42 5 5
HRAS 0.017 0 -9999 0 -10000 0 0
APS homodimer 0 0 -9999 0 -10000 0 0
GRB14 -0.081 0.25 -9999 0 -0.69 31 31
FOXO3 -0.008 0.019 -9999 0 -10000 0 0
AKT1 0.019 0.14 -9999 0 -0.58 1 1
INSR 0.011 0.074 -9999 0 -0.63 3 3
Insulin Receptor/Insulin -0.005 0.037 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
GRB10 -0.029 0.18 -9999 0 -0.72 14 14
SORBS1 -0.027 0.16 -9999 0 -0.64 15 15
CRK 0.014 0.043 -9999 0 -0.63 1 1
PTPN1 0.052 0.044 -9999 0 -10000 0 0
CAV1 0.027 0.1 -9999 0 -0.63 3 3
CBL/APS/CAP/Crk-II/C3G -0.023 0.084 -9999 0 -0.39 1 1
Insulin Receptor/Insulin/IRS1/NCK2 -0.012 0.065 -9999 0 -0.42 4 4
mol:GDP 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.01 0.056 -9999 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.049 0.074 -9999 0 -0.52 3 3
RPS6KB1 0.028 0.13 -9999 0 -0.52 1 1
PARD6A -0.013 0.14 -9999 0 -0.72 9 9
CBL 0.017 0 -9999 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -9999 0 -10000 0 0
DOK1 0.006 0.037 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.042 0.095 -9999 0 -0.53 1 1
HRAS/GTP -0.008 0.047 -9999 0 -10000 0 0
Insulin Receptor 0.011 0.074 -9999 0 -0.62 3 3
Insulin Receptor/Insuli/IRS1/GRB2/SHC -0.011 0.059 -9999 0 -10000 0 0
PRKCI -0.017 0.048 -9999 0 -10000 0 0
Insulin Receptor/Insulin/GRB14/PDK1 -0.051 0.12 -9999 0 -0.63 1 1
SHC1 0.017 0 -9999 0 -10000 0 0
negative regulation of MAPKKK cascade 0.002 0.058 -9999 0 -0.68 1 1
PI3K -0.01 0.057 -9999 0 -10000 0 0
NCK2 0.017 0 -9999 0 -10000 0 0
RHOQ 0.017 0 -9999 0 -10000 0 0
mol:H2O2 -0.001 0.005 -9999 0 -10000 0 0
HRAS/GDP 0 0 -9999 0 -10000 0 0
AKT2 0.019 0.14 -9999 0 -0.58 1 1
PRKCZ -0.012 0.028 -9999 0 -10000 0 0
SH2B2 0 0 -9999 0 -10000 0 0
SHC/SHIP -0.01 0.058 -9999 0 -0.37 4 4
F2RL2 0.004 0.098 -9999 0 -0.72 4 4
TRIP10 0.017 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/Shc -0.004 0.037 -9999 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB2/Sos1 -0.004 0.032 -9999 0 -10000 0 0
RAPGEF1 0.017 0 -9999 0 -10000 0 0
RASA1 0.01 0.07 -9999 0 -0.72 2 2
NCK1 0.017 0 -9999 0 -10000 0 0
CBL/APS/CAP/Crk-II -0.025 0.091 -9999 0 -0.35 16 16
TC10/GDP 0 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB10 -0.03 0.11 -9999 0 -0.42 14 14
INPP5D 0.022 0.069 -9999 0 -0.4 4 4
SOS1 0.017 0 -9999 0 -10000 0 0
SGK1 -0.005 0.011 -9999 0 -10000 0 0
mol:cAMP 0 0 -9999 0 -10000 0 0
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
IRS1 0.004 0.098 -9999 0 -0.72 4 4
p62DOK/RasGAP 0.002 0.059 -9999 0 -0.69 1 1
INS 0.019 0.004 -9999 0 -10000 0 0
mol:PI-3-4-P2 0.022 0.068 -9999 0 -0.4 4 4
GRB2 0.017 0 -9999 0 -10000 0 0
EIF4EBP1 0.013 0.15 -9999 0 -0.56 2 2
PTPRA 0.017 0.043 -9999 0 -0.63 1 1
PIK3CA 0.017 0 -9999 0 -10000 0 0
TC10/GTP/CIP4 0 0 -9999 0 -10000 0 0
PDPK1 0.017 0 -9999 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.045 0.049 -9999 0 -10000 0 0
Insulin Receptor/Insulin/IRS1 -0.012 0.067 -9999 0 -0.43 4 4
Insulin Receptor/Insulin/IRS3 -0.006 0.052 -9999 0 -0.45 3 3
Par3/Par6 -0.022 0.09 -9999 0 -10000 0 0
Neurotrophic factor-mediated Trk receptor signaling

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.017 0 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 -0.006 0.035 -10000 0 -10000 0 0
NT3 (dimer)/TRKC -0.005 0.051 -10000 0 -0.54 2 2
NT3 (dimer)/TRKB -0.028 0.1 -10000 0 -0.42 15 15
SHC/Grb2/SOS1/GAB1/PI3K 0.048 0.029 -10000 0 -10000 0 0
RAPGEF1 0.017 0 -10000 0 -10000 0 0
BDNF -0.036 0.19 -10000 0 -0.72 16 16
PIK3CA 0.017 0 -10000 0 -10000 0 0
DYNLT1 0.017 0 -10000 0 -10000 0 0
NTRK1 0.017 0 -10000 0 -10000 0 0
NTRK2 -0.023 0.16 -10000 0 -0.67 13 13
NTRK3 0.017 0 -10000 0 -10000 0 0
NT-4/5 (dimer)/TRKB -0.025 0.099 -10000 0 -0.42 13 13
neuron apoptosis 0.039 0.081 0.41 1 -0.22 1 2
SHC 2-3/Grb2 -0.042 0.086 0.23 1 -0.44 1 2
SHC1 0.017 0 -10000 0 -10000 0 0
SHC2 -0.024 0.067 -10000 0 -0.37 2 2
SHC3 -0.032 0.08 -10000 0 -0.4 3 3
STAT3 (dimer) -0.021 0.11 -10000 0 -10000 0 0
NT3 (dimer)/TRKA -0.004 0.043 -10000 0 -0.46 2 2
RIN/GDP 0.084 0.029 -10000 0 -10000 0 0
GIPC1 0.014 0.043 -10000 0 -0.63 1 1
KRAS 0.017 0 -10000 0 -10000 0 0
DNAJA3 -0.002 0.039 -10000 0 -0.38 2 2
RIN/GTP 0 0 -10000 0 -10000 0 0
CCND1 -0.061 0.24 -10000 0 -0.62 35 35
MAGED1 0.014 0.049 -10000 0 -0.72 1 1
PTPN11 0.014 0.049 -10000 0 -0.72 1 1
RICS 0.017 0 -10000 0 -10000 0 0
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0 0 -10000 0 -10000 0 0
GRB2 0.017 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK 0 0 -10000 0 -10000 0 0
TRKA/NEDD4-2 -0.053 0.15 -10000 0 -0.46 26 26
ELMO1 0.017 0 -10000 0 -10000 0 0
RhoG/GTP/ELMO1/DOCK1 -0.004 0.037 -10000 0 -0.4 2 2
NGF 0 0 -10000 0 -10000 0 0
HRAS 0.017 0 -10000 0 -10000 0 0
DOCK1 0.011 0.061 -10000 0 -0.63 2 2
GAB2 0.017 0 -10000 0 -10000 0 0
RIT2 0.017 0 -10000 0 -10000 0 0
RIT1 0.017 0 -10000 0 -10000 0 0
FRS2 0.017 0 -10000 0 -10000 0 0
DNM1 0.01 0.07 -10000 0 -0.72 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.014 0.043 -10000 0 -0.63 1 1
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP 0.001 0.016 0.24 1 -10000 0 1
mol:GDP 0.1 0.039 -10000 0 -10000 0 0
NGF (dimer) 0 0 -10000 0 -10000 0 0
RhoG/GDP 0 0 -10000 0 -10000 0 0
RIT1/GDP 0.084 0.029 -10000 0 -10000 0 0
TIAM1 0.011 0.061 -10000 0 -0.63 2 2
PIK3R1 0.017 0 -10000 0 -10000 0 0
BDNF (dimer)/TRKB -0.056 0.15 -10000 0 -0.45 28 28
KIDINS220/CRKL/C3G 0 0 -10000 0 -10000 0 0
SHC/RasGAP -0.005 0.051 -10000 0 -0.54 2 2
FRS2 family/SHP2 -0.002 0.03 -10000 0 -0.46 1 1
SHC/GRB2/SOS1/GAB1 -0.003 0.032 -10000 0 -10000 0 0
RIT1/GTP 0 0 -10000 0 -10000 0 0
NT3 (dimer) 0.01 0.069 -10000 0 -0.72 2 2
RAP1/GDP -0.001 0.008 -10000 0 -10000 0 0
KIDINS220/CRKL 0.017 0 -10000 0 -10000 0 0
BDNF (dimer) -0.036 0.19 -10000 0 -0.72 16 16
ubiquitin-dependent protein catabolic process -0.046 0.13 -10000 0 -0.39 26 26
Schwann cell development -0.009 0.02 -10000 0 -10000 0 0
EHD4 0.017 0 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0 0 -10000 0 -10000 0 0
FRS2 family/SHP2/CRK family/C3G/GAB2 0.053 0.024 -10000 0 -10000 0 0
RAP1B 0.017 0 -10000 0 -10000 0 0
RAP1A 0.017 0 -10000 0 -10000 0 0
CDC42/GTP -0.043 0.12 -10000 0 -0.68 2 2
ABL1 0.017 0 -10000 0 -10000 0 0
SH2B family/GRB2/SOS1 0 0 -10000 0 -10000 0 0
Rap1/GTP -0.017 0.045 -10000 0 -10000 0 0
STAT3 -0.021 0.11 -10000 0 -10000 0 0
axon guidance -0.041 0.11 -10000 0 -0.65 2 2
MAPK3 0.031 0.036 -10000 0 -10000 0 0
MAPK1 0.033 0.026 -10000 0 -10000 0 0
CDC42/GDP 0.084 0.029 -10000 0 -10000 0 0
NTF3 0.01 0.07 -10000 0 -0.72 2 2
NTF4 0 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM -0.006 0.054 -10000 0 -0.47 3 3
PI3K 0 0 -10000 0 -10000 0 0
FRS3 0.017 0 -10000 0 -10000 0 0
FAIM 0.007 0.085 -10000 0 -0.72 3 3
GAB1 0.011 0.061 -10000 0 -0.63 2 2
RASGRF1 -0.023 0.093 -10000 0 -0.38 14 14
SOS1 0.017 0 -10000 0 -10000 0 0
MCF2L 0.034 0.046 -10000 0 -0.46 2 2
RGS19 0.017 0 -10000 0 -10000 0 0
CDC42 0.017 0 -10000 0 -10000 0 0
RAS family/GTP 0.07 0.042 -10000 0 -10000 0 0
Rac1/GDP 0.084 0.029 -10000 0 -10000 0 0
NGF (dimer)/TRKA/GRIT 0 0 -10000 0 -10000 0 0
neuron projection morphogenesis 0.029 0.054 -10000 0 -10000 0 0
NGF (dimer)/TRKA/NEDD4-2 -0.046 0.13 -10000 0 -0.4 26 26
MAP2K1 0.051 0.034 -10000 0 -10000 0 0
NGFR 0.017 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/GIPC/GAIP 0.039 0.031 -10000 0 -10000 0 0
RAS family/GTP/PI3K 0.039 0.03 -10000 0 -10000 0 0
FRS2 family/SHP2/GRB2/SOS1 -0.002 0.025 -10000 0 -10000 0 0
NRAS 0.007 0.085 -10000 0 -0.72 3 3
GRB2/SOS1 0 0 -10000 0 -10000 0 0
PRKCI -0.003 0.12 -10000 0 -0.72 6 6
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.017 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
MAPKKK cascade -0.012 0.031 -10000 0 -10000 0 0
RASA1 0.01 0.07 -10000 0 -0.72 2 2
TRKA/c-Abl 0 0 -10000 0 -10000 0 0
SQSTM1 0.017 0 -10000 0 -10000 0 0
BDNF (dimer)/TRKB/GIPC -0.052 0.14 -10000 0 -0.44 21 21
NGF (dimer)/TRKA/p62/Atypical PKCs -0.011 0.064 -10000 0 -0.4 6 6
MATK 0.017 0 -10000 0 -10000 0 0
NEDD4L -0.058 0.21 -10000 0 -0.63 26 26
RAS family/GDP -0.003 0.022 -10000 0 -10000 0 0
NGF (dimer)/TRKA 0.001 0.017 0.26 1 -10000 0 1
Rac1/GTP -0.016 0.055 -10000 0 -0.32 1 1
FRS2 family/SHP2/CRK family -0.003 0.032 -10000 0 -10000 0 0
LPA4-mediated signaling events

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 0.025 0.028 -9999 0 -0.4 1 1
ADCY5 0.027 0 -9999 0 -10000 0 0
ADCY6 0.027 0 -9999 0 -10000 0 0
ADCY7 0.027 0 -9999 0 -10000 0 0
ADCY1 0.027 0 -9999 0 -10000 0 0
ADCY2 0.025 0.033 -9999 0 -0.47 1 1
ADCY3 -0.002 0.12 -9999 0 -0.47 13 13
ADCY8 0.025 0.033 -9999 0 -0.47 1 1
PRKCE 0.016 0 -9999 0 -10000 0 0
ADCY9 0.022 0.049 -9999 0 -0.4 3 3
mol:DAG 0 0 -9999 0 -10000 0 0
cAMP biosynthetic process 0.045 0.03 -9999 0 -10000 0 0
ErbB2/ErbB3 signaling events

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 0.029 0.003 -10000 0 -10000 0 0
RAS family/GTP -0.006 0.039 -10000 0 -10000 0 0
NFATC4 0.055 0.061 -10000 0 -10000 0 0
ERBB2IP 0.007 0.074 -10000 0 -0.63 3 3
HSP90 (dimer) 0.014 0.049 -10000 0 -0.72 1 1
mammary gland morphogenesis -0.005 0.057 -10000 0 -10000 0 0
JUN 0.08 0.071 -10000 0 -10000 0 0
HRAS 0.017 0.001 -10000 0 -10000 0 0
DOCK7 0.052 0.065 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC -0.008 0.073 -10000 0 -10000 0 0
AKT1 0.017 0.002 -10000 0 -10000 0 0
BAD 0.028 0.001 -10000 0 -10000 0 0
MAPK10 -0.008 0.038 -10000 0 -0.33 1 1
mol:GTP 0 0.001 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta 0.046 0.071 -10000 0 -10000 0 0
RAF1 0.08 0.063 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 2 -0.017 0.093 -10000 0 -0.42 6 6
STAT3 0.001 0.003 -10000 0 -10000 0 0
cell migration 0.07 0.045 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.001 0.001 -10000 0 -10000 0 0
cell proliferation 0.087 0.16 -10000 0 -10000 0 0
FOS 0.042 0.23 -10000 0 -0.51 32 32
NRAS 0.007 0.085 -10000 0 -0.72 3 3
mol:Ca2+ -0.005 0.057 -10000 0 -10000 0 0
MAPK3 0.091 0.12 -10000 0 -10000 0 0
MAPK1 0.092 0.12 -10000 0 -10000 0 0
JAK2 0.046 0.08 -10000 0 -10000 0 0
NF2 0 0.001 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 0.041 0.028 -10000 0 -10000 0 0
NRG1 0.018 0.002 -10000 0 -10000 0 0
GRB2/SOS1 0 0 -10000 0 -10000 0 0
MAPK8 0.059 0.055 -10000 0 -10000 0 0
MAPK9 -0.004 0.022 -10000 0 -10000 0 0
ERBB2 -0.011 0.11 0.42 3 -0.54 7 10
ERBB3 0.018 0.002 -10000 0 -10000 0 0
SHC1 0.017 0.001 -10000 0 -10000 0 0
RAC1 0.017 0 -10000 0 -10000 0 0
apoptosis 0.001 0.004 -10000 0 -10000 0 0
STAT3 (dimer) 0.001 0.003 -10000 0 -10000 0 0
RNF41 0.039 0.004 -10000 0 -10000 0 0
FRAP1 0.028 0.001 -10000 0 -10000 0 0
RAC1-CDC42/GTP -0.006 0.031 -10000 0 -10000 0 0
ErbB2/ErbB2/HSP90 (dimer) -0.013 0.092 0.28 3 -0.46 8 11
CHRNA1 0.092 0.1 -10000 0 -10000 0 0
myelination 0.071 0.056 -10000 0 -10000 0 0
PPP3CB 0.05 0.061 -10000 0 -10000 0 0
KRAS 0.017 0.001 -10000 0 -10000 0 0
RAC1-CDC42/GDP -0.002 0.01 -10000 0 -10000 0 0
NRG2 0.002 0.096 -10000 0 -0.63 5 5
mol:GDP 0.041 0.028 -10000 0 -10000 0 0
SOS1 0.017 0.001 -10000 0 -10000 0 0
MAP2K2 0.091 0.064 -10000 0 -10000 0 0
SRC 0.017 0 -10000 0 -10000 0 0
mol:cAMP 0 0.001 -10000 0 -10000 0 0
PTPN11 0.049 0.068 -10000 0 -10000 0 0
MAP2K1 0.08 0.11 -10000 0 -10000 0 0
heart morphogenesis -0.005 0.057 -10000 0 -10000 0 0
RAS family/GDP -0.006 0.04 -10000 0 -10000 0 0
GRB2 0.017 0.001 -10000 0 -10000 0 0
PRKACA 0 0.003 -10000 0 -10000 0 0
CHRNE 0.035 0.018 -10000 0 -10000 0 0
HSP90AA1 0.014 0.049 -10000 0 -0.72 1 1
activation of caspase activity -0.017 0.002 -10000 0 -10000 0 0
nervous system development -0.005 0.057 -10000 0 -10000 0 0
CDC42 0.017 0 -10000 0 -10000 0 0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.008 0.075 -9999 0 -0.63 3 3
SMAD2 0.018 0.034 -9999 0 -10000 0 0
SMAD3 0.045 0.063 -9999 0 -0.49 1 1
SMAD3/SMAD4 0.042 0.067 -9999 0 -0.36 1 1
SMAD4/Ubc9/PIASy -0.007 0.053 -9999 0 -0.4 4 4
SMAD2/SMAD2/SMAD4 -0.019 0.075 -9999 0 -10000 0 0
PPM1A 0.017 0 -9999 0 -10000 0 0
CALM1 0.017 0 -9999 0 -10000 0 0
SMAD2/SMAD4 0.022 0.052 -9999 0 -0.34 3 3
MAP3K1 0.017 0 -9999 0 -10000 0 0
TRAP-1/SMAD4 -0.006 0.053 -9999 0 -0.46 3 3
MAPK3 0.011 0.061 -9999 0 -0.63 2 2
MAPK1 0.014 0.043 -9999 0 -0.63 1 1
NUP214 0.017 0 -9999 0 -10000 0 0
CTDSP1 0.017 0 -9999 0 -10000 0 0
CTDSP2 0.008 0.075 -9999 0 -0.63 3 3
CTDSPL 0.011 0.061 -9999 0 -0.63 2 2
KPNB1 -0.003 0.12 -9999 0 -0.72 6 6
TGFBRAP1 0.017 0 -9999 0 -10000 0 0
UBE2I 0.014 0.049 -9999 0 -0.72 1 1
NUP153 0.017 0 -9999 0 -10000 0 0
KPNA2 -0.013 0.14 -9999 0 -0.72 9 9
PIAS4 0.017 0 -9999 0 -10000 0 0
Signaling events mediated by HDAC Class II

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0 0 -9999 0 -10000 0 0
HDAC3 0.017 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.003 0.032 -9999 0 -10000 0 0
GATA1/HDAC4 -0.002 0.036 -9999 0 -0.54 1 1
GATA1/HDAC5 -0.002 0.036 -9999 0 -0.54 1 1
GATA2/HDAC5 0 0 -9999 0 -10000 0 0
HDAC5/BCL6/BCoR -0.004 0.04 -9999 0 -0.46 1 1
HDAC9 0.017 0 -9999 0 -10000 0 0
Glucocorticoid receptor/Hsp90/HDAC6 -0.043 0.12 -9999 0 -0.39 25 25
HDAC4/ANKRA2 0 0 -9999 0 -10000 0 0
HDAC5/YWHAB 0 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.024 0.034 -9999 0 -10000 0 0
GATA2 0.017 0 -9999 0 -10000 0 0
HDAC4/RFXANK 0 0 -9999 0 -10000 0 0
BCOR 0.017 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
HDAC10 0.007 0.085 -9999 0 -0.72 3 3
HDAC5 0.017 0 -9999 0 -10000 0 0
GNB1/GNG2 0 0 -9999 0 -10000 0 0
Histones 0.044 0.024 -9999 0 -10000 0 0
ADRBK1 0.017 0 -9999 0 -10000 0 0
HDAC4 0.017 0 -9999 0 -10000 0 0
XPO1 0.017 0 -9999 0 -10000 0 0
HDAC5/ANKRA2 0 0 -9999 0 -10000 0 0
HDAC4/Ubc9 -0.002 0.036 -9999 0 -0.54 1 1
HDAC7 0 0 -9999 0 -10000 0 0
HDAC5/14-3-3 E -0.002 0.036 -9999 0 -0.54 1 1
TUBA1B 0.017 0 -9999 0 -10000 0 0
HDAC6 0.017 0 -9999 0 -10000 0 0
HDAC5/RFXANK 0 0 -9999 0 -10000 0 0
CAMK4 0.017 0 -9999 0 -10000 0 0
Tubulin/HDAC6 0 0 -9999 0 -10000 0 0
SUMO1 0.017 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
YWHAB 0.017 0 -9999 0 -10000 0 0
GATA1 0.014 0.049 -9999 0 -0.72 1 1
EntrezGene:8021 0 0 -9999 0 -10000 0 0
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
NR3C1 -0.053 0.2 -9999 0 -0.63 24 24
SUMO1/HDAC4 -0.004 0.024 -9999 0 -10000 0 0
SRF 0.017 0 -9999 0 -10000 0 0
HDAC4/YWHAB 0 0 -9999 0 -10000 0 0
Tubulin 0 0 -9999 0 -10000 0 0
HDAC4/14-3-3 E -0.002 0.036 -9999 0 -0.54 1 1
GNB1 0.017 0 -9999 0 -10000 0 0
RANGAP1 0.004 0.098 -9999 0 -0.72 4 4
BCL6/BCoR -0.004 0.047 -9999 0 -0.5 2 2
HDAC4/HDAC3/SMRT (N-CoR2) 0 0 -9999 0 -10000 0 0
HDAC4/SRF 0 0 -9999 0 -10000 0 0
HDAC4/ER alpha -0.012 0.074 -9999 0 -0.46 6 6
EntrezGene:23225 0 0 -9999 0 -10000 0 0
positive regulation of chromatin silencing 0.044 0.024 -9999 0 -10000 0 0
cell motility 0 0 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
UBE2I 0.014 0.049 -9999 0 -0.72 1 1
HDAC7/HDAC3 0 0 -9999 0 -10000 0 0
BCL6 0.011 0.065 -9999 0 -0.68 2 2
HDAC4/CaMK II delta B 0.017 0 -9999 0 -10000 0 0
Hsp90/HDAC6 -0.002 0.036 -9999 0 -0.54 1 1
ESR1 0 0.1 -9999 0 -0.63 6 6
HDAC6/HDAC11 0 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 -0.005 0.032 -9999 0 -0.35 1 1
NPC -0.002 0.028 -9999 0 -0.42 1 1
MEF2C -0.085 0.24 -9999 0 -0.63 35 35
RAN 0.014 0.049 -9999 0 -0.72 1 1
HDAC4/MEF2C -0.05 0.12 -9999 0 -0.71 1 1
GNG2 0.017 0 -9999 0 -10000 0 0
NCOR2 0.017 0 -9999 0 -10000 0 0
TUBB2A 0.017 0 -9999 0 -10000 0 0
HDAC11 0.017 0 -9999 0 -10000 0 0
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
RANBP2 0.014 0.049 -9999 0 -0.72 1 1
ANKRA2 0.017 0 -9999 0 -10000 0 0
RFXANK 0.017 0 -9999 0 -10000 0 0
nuclear import 0.001 0.021 -9999 0 -10000 0 0
Insulin-mediated glucose transport

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles -0.054 0.086 -9999 0 -0.36 3 3
CaM/Ca2+ 0 0 -9999 0 -10000 0 0
AKT1 0.017 0 -9999 0 -10000 0 0
AKT2 0.017 0 -9999 0 -10000 0 0
STXBP4 0.017 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
mol:glucose -0.017 0.13 -9999 0 -0.36 4 4
YWHAZ 0.017 0 -9999 0 -10000 0 0
CALM1 0.017 0 -9999 0 -10000 0 0
YWHAQ 0.017 0 -9999 0 -10000 0 0
TBC1D4 0.001 0.13 -9999 0 -0.53 12 12
mol:Ca2+ 0 0 -9999 0 -10000 0 0
YWHAH 0.017 0 -9999 0 -10000 0 0
YWHAB 0.017 0 -9999 0 -10000 0 0
SNARE/Synip 0 0 -9999 0 -10000 0 0
YWHAG 0.017 0 -9999 0 -10000 0 0
ASIP 0 0 -9999 0 -10000 0 0
PRKCI -0.003 0.12 -9999 0 -0.72 6 6
AS160/CaM/Ca2+ 0 0 -9999 0 -10000 0 0
RHOQ 0.017 0 -9999 0 -10000 0 0
GYS1 0.042 0.019 -9999 0 -10000 0 0
PRKCZ 0 0 -9999 0 -10000 0 0
TRIP10 0.017 0 -9999 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0 0 -9999 0 -10000 0 0
AS160/14-3-3 0.051 0.05 -9999 0 -10000 0 0
VAMP2 0.017 0 -9999 0 -10000 0 0
SLC2A4 -0.021 0.14 -9999 0 -0.4 4 4
STX4 0.017 0 -9999 0 -10000 0 0
GSK3B 0.034 0.022 -9999 0 -10000 0 0
SFN 0.011 0.061 -9999 0 -0.63 2 2
LNPEP 0.017 0 -9999 0 -10000 0 0
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
mTOR signaling pathway

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0.017 0 -10000 0 -10000 0 0
MKNK1 0.017 0 -10000 0 -10000 0 0
mol:PIP3 0.005 0.055 0.3 6 -10000 0 6
FRAP1 0.032 0.019 -10000 0 -10000 0 0
AKT1 0.004 0.044 0.25 6 -10000 0 6
INSR 0.008 0.075 -10000 0 -0.63 3 3
Insulin Receptor/Insulin -0.005 0.045 -10000 0 -0.4 3 3
mol:GTP -0.002 0.012 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit 0 0.002 -10000 0 -10000 0 0
TSC2 0.017 0 -10000 0 -10000 0 0
RHEB/GDP -0.001 0.01 -10000 0 -10000 0 0
TSC1 0.017 0 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.014 0.052 -10000 0 -0.34 3 3
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0 0.003 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.017 0 -10000 0 -10000 0 0
RPS6KB1 0.047 0.031 -10000 0 -10000 0 0
MAP3K5 0.011 0.031 -10000 0 -0.32 2 2
PIK3R1 0.017 0 -10000 0 -10000 0 0
apoptosis 0.011 0.031 -10000 0 -0.32 2 2
mol:LY294002 0 0 -10000 0 -0.001 4 4
EIF4B 0.054 0.029 -10000 0 -10000 0 0
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.007 0.042 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1 0 0 -10000 0 -10000 0 0
KIAA1303 0.017 0 -10000 0 -10000 0 0
PI3K 0.029 0.03 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.068 0.025 -10000 0 -10000 0 0
FKBP1A 0.017 0.001 -10000 0 -10000 0 0
RHEB/GTP -0.001 0.009 -10000 0 -10000 0 0
mol:Amino Acids 0 0 -10000 0 -0.001 4 4
FKBP12/Rapamycin 0.001 0.004 -10000 0 -10000 0 0
PDPK1 0.004 0.046 0.25 6 -10000 0 6
EIF4E 0.017 0 -10000 0 -10000 0 0
ASK1/PP5C 0.035 0.03 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.045 0.007 -10000 0 -10000 0 0
TSC1/TSC2 -0.002 0.013 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 0.001 4 -10000 0 4
RPS6 0 0.11 -10000 0 -0.72 5 5
PPP5C 0.014 0.049 -10000 0 -0.72 1 1
EIF4G1 0.017 0 -10000 0 -10000 0 0
IRS1 0.008 0.034 -10000 0 -0.24 4 4
INS 0.017 0 -10000 0 -10000 0 0
PTEN -0.001 0.1 -10000 0 -0.63 6 6
PDK2 0.004 0.046 0.25 6 -10000 0 6
EIF4EBP1 0.002 0.065 -10000 0 -10000 0 0
PIK3CA 0.017 0 -10000 0 -10000 0 0
PPP2R5D 0.041 0.018 -10000 0 -10000 0 0
peptide biosynthetic process 0.029 0.044 -10000 0 -0.35 3 3
RHEB 0.017 0 -10000 0 -10000 0 0
EIF4A1 0.017 0 -10000 0 -10000 0 0
mol:Rapamycin 0.001 0.001 0.004 6 -10000 0 6
EEF2 0.03 0.044 -10000 0 -0.35 3 3
eIF4E/4E-BP1 0.012 0.058 -10000 0 -10000 0 0
Class I PI3K signaling events mediated by Akt

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.029 0.038 -9999 0 -0.54 1 1
BAD/BCL-XL/YWHAZ -0.002 0.027 -9999 0 -10000 0 0
CDKN1B 0.031 0.08 -9999 0 -10000 0 0
CDKN1A 0.029 0.084 -9999 0 -10000 0 0
FRAP1 0.017 0 -9999 0 -10000 0 0
PRKDC -0.046 0.21 -9999 0 -0.72 19 19
FOXO3 0.033 0.076 -9999 0 -10000 0 0
AKT1 -0.021 0.065 -9999 0 -10000 0 0
BAD 0.017 0 -9999 0 -10000 0 0
AKT3 0.023 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
FOXO4 0.033 0.076 -9999 0 -10000 0 0
AKT1/ASK1 -0.021 0.065 -9999 0 -10000 0 0
BAD/YWHAZ 0 0 -9999 0 -10000 0 0
RICTOR 0.014 0.049 -9999 0 -0.72 1 1
RAF1 0.017 0 -9999 0 -10000 0 0
JNK cascade 0.021 0.063 -9999 0 -10000 0 0
TSC1 0.033 0.076 -9999 0 -10000 0 0
YWHAZ 0.017 0 -9999 0 -10000 0 0
AKT1/RAF1 0.032 0.075 -9999 0 -10000 0 0
EP300 0.017 0 -9999 0 -10000 0 0
mol:GDP -0.02 0.064 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 0 0 -9999 0 -10000 0 0
TSC2 0.033 0.076 -9999 0 -10000 0 0
YWHAQ 0.017 0 -9999 0 -10000 0 0
TBC1D4 0.008 0.11 -9999 0 -0.45 12 12
MAP3K5 0.01 0.07 -9999 0 -0.72 2 2
MAPKAP1 0.007 0.085 -9999 0 -0.72 3 3
negative regulation of cell cycle -0.051 0.036 -9999 0 -10000 0 0
YWHAH 0.017 0 -9999 0 -10000 0 0
AKT1S1 0.033 0.076 -9999 0 -10000 0 0
CASP9 0.033 0.076 -9999 0 -10000 0 0
YWHAB 0.017 0 -9999 0 -10000 0 0
p27Kip1/KPNA1 0.04 0.076 -9999 0 -10000 0 0
GBL 0.017 0 -9999 0 -10000 0 0
PDK1/Src/Hsp90 -0.002 0.03 -9999 0 -0.46 1 1
YWHAE 0.014 0.049 -9999 0 -0.72 1 1
SRC 0.017 0 -9999 0 -10000 0 0
AKT2/p21CIP1 -0.02 0.061 -9999 0 -10000 0 0
KIAA1303 0.017 0 -9999 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.042 0.026 -9999 0 -10000 0 0
CHUK 0.033 0.076 -9999 0 -10000 0 0
BAD/BCL-XL 0.048 0.075 -9999 0 -10000 0 0
mTORC2 -0.007 0.054 -9999 0 -0.41 4 4
AKT2 0.023 0 -9999 0 -10000 0 0
FOXO1-3a-4/14-3-3 family 0.062 0.063 -9999 0 -10000 0 0
PDPK1 0.017 0 -9999 0 -10000 0 0
MDM2 0.033 0.076 -9999 0 -10000 0 0
MAPKKK cascade -0.031 0.074 -9999 0 -10000 0 0
MDM2/Cbp/p300 -0.015 0.049 -9999 0 -10000 0 0
TSC1/TSC2 0.042 0.073 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process -0.015 0.048 -9999 0 -10000 0 0
glucose import -0.093 0.2 -9999 0 -0.51 12 12
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.049 0.053 -9999 0 -10000 0 0
response to stress 0 0 -9999 0 -10000 0 0
SLC2A4 -0.094 0.2 -9999 0 -0.52 12 12
GSK3A 0.033 0.076 -9999 0 -10000 0 0
FOXO1 0.018 0.1 -9999 0 -0.54 1 1
GSK3B 0.031 0.085 -9999 0 -0.6 1 1
SFN 0.011 0.061 -9999 0 -0.63 2 2
G1/S transition of mitotic cell cycle 0.041 0.083 -9999 0 -0.57 1 1
p27Kip1/14-3-3 family 0.058 0.032 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
KPNA1 0.017 0 -9999 0 -10000 0 0
HSP90AA1 0.014 0.049 -9999 0 -0.72 1 1
YWHAG 0.017 0 -9999 0 -10000 0 0
RHEB 0.017 0 -9999 0 -10000 0 0
CREBBP 0.017 0 -9999 0 -10000 0 0
Signaling events regulated by Ret tyrosine kinase

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.005 0.027 -9999 0 -10000 0 0
Crk/p130 Cas/Paxillin -0.012 0.044 -9999 0 -10000 0 0
JUN 0.046 0.084 -9999 0 -10000 0 0
HRAS 0.017 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 -0.04 0.14 -9999 0 -0.78 3 3
RAP1A 0.017 0 -9999 0 -10000 0 0
FRS2 0.017 0 -9999 0 -10000 0 0
RAP1A/GDP 0 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/DOK1 -0.017 0.078 -9999 0 -10000 0 0
EntrezGene:5979 0 0 -9999 0 -10000 0 0
PTPN11 0.014 0.049 -9999 0 -0.72 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
RET9/GFRalpha1/GDNF/Enigma -0.002 0.028 -9999 0 -0.42 1 1
RHOA 0.017 0 -9999 0 -10000 0 0
RAP1A/GTP -0.017 0.072 -9999 0 -10000 0 0
GRB7 -0.009 0.14 -9999 0 -0.72 8 8
RET51/GFRalpha1/GDNF -0.015 0.073 -9999 0 -10000 0 0
MAPKKK cascade -0.013 0.059 -9999 0 -10000 0 0
BCAR1 0.017 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 -0.007 0.056 -9999 0 -0.42 4 4
lamellipodium assembly -0.011 0.04 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC -0.015 0.073 -9999 0 -0.41 4 4
PIK3CA 0.017 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC 0 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3 0 0 -9999 0 -10000 0 0
MAPK3 0.039 0.085 -9999 0 -10000 0 0
DOK1 0.014 0.049 -9999 0 -0.72 1 1
DOK6 0.017 0 -9999 0 -10000 0 0
PXN 0.017 0 -9999 0 -10000 0 0
neurite development 0.055 0.088 -9999 0 -10000 0 0
DOK5 -0.009 0.14 -9999 0 -0.72 8 8
GFRA1 0.017 0 -9999 0 -10000 0 0
MAPK8 0.046 0.062 -9999 0 -10000 0 0
HRAS/GTP -0.015 0.07 -9999 0 -0.48 1 1
tube development 0 0 -9999 0 -10000 0 0
MAPK1 0.04 0.083 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.041 0.017 -9999 0 -10000 0 0
Rac1/GDP 0 0 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
PDLIM7 0.014 0.049 -9999 0 -0.72 1 1
RET51/GFRalpha1/GDNF/Dok6 -0.014 0.067 -9999 0 -10000 0 0
SHC1 0.017 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 -0.019 0.082 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok5 -0.029 0.1 -9999 0 -10000 0 0
PRKCA 0.014 0.049 -9999 0 -0.72 1 1
HRAS/GDP 0 0 -9999 0 -10000 0 0
CREB1 0.048 0.029 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.04 0.029 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Grb7 -0.029 0.1 -9999 0 -0.41 12 12
mol:GDP 0 0 -9999 0 -10000 0 0
RET -0.011 0.14 -9999 0 -0.67 9 9
DOK4 0.008 0.075 -9999 0 -0.63 3 3
JNK cascade 0.046 0.083 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/FRS2 0 0 -9999 0 -10000 0 0
SHANK3 0.017 0 -9999 0 -10000 0 0
RASA1 0.01 0.07 -9999 0 -0.72 2 2
NCK1 0.017 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.042 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.038 0.058 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK 0.036 0.066 -9999 0 -0.42 1 1
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.039 0.056 -9999 0 -10000 0 0
PI3K 0.068 0.079 -9999 0 -10000 0 0
SOS1 0.017 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 0 0 -9999 0 -10000 0 0
GRB10 -0.029 0.18 -9999 0 -0.72 14 14
activation of MAPKK activity 0.041 0.044 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/FRS2 -0.015 0.073 -9999 0 -10000 0 0
GAB1 0.011 0.061 -9999 0 -0.63 2 2
IRS1 0.004 0.098 -9999 0 -0.72 4 4
IRS2 0.014 0.049 -9999 0 -0.72 1 1
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.037 0.062 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/PKC alpha -0.017 0.078 -9999 0 -10000 0 0
GRB2 0.017 0 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
GDNF 0.017 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 -0.022 0.09 -9999 0 -10000 0 0
Rac1/GTP -0.012 0.046 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF 0 0 -9999 0 -10000 0 0
GFRalpha1/GDNF 0 0 -9999 0 -10000 0 0
S1P5 pathway

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
telencephalon oligodendrocyte cell migration 0.025 0.064 -9999 0 -10000 0 0
GNAI2 0.017 0 -9999 0 -10000 0 0
S1P/S1P5/G12 0 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
GNAO1 0.017 0 -9999 0 -10000 0 0
RhoA/GTP -0.025 0.065 -9999 0 -10000 0 0
negative regulation of cAMP metabolic process 0.005 0.088 -9999 0 -10000 0 0
GNAZ 0.017 0 -9999 0 -10000 0 0
GNAI3 0.017 0 -9999 0 -10000 0 0
GNA12 0.017 0 -9999 0 -10000 0 0
S1PR5 0 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
S1P/S1P5/Gi 0.004 0.088 -9999 0 -10000 0 0
RhoA/GDP 0 0 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
GNAI1 -0.07 0.22 -9999 0 -0.63 30 30
Paxillin-dependent events mediated by a4b1

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.017 0 -9999 0 -10000 0 0
Rac1/GDP 0.001 0.007 -9999 0 -10000 0 0
DOCK1 0.011 0.061 -9999 0 -0.63 2 2
ITGA4 0.011 0.061 -9999 0 -0.63 2 2
RAC1 0.017 0 -9999 0 -10000 0 0
alpha4/beta7 Integrin -0.023 0.099 -9999 0 -0.46 11 11
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.014 0.043 -9999 0 -0.63 1 1
alpha4/beta1 Integrin -0.005 0.047 -9999 0 -0.46 1 1
alpha4/beta7 Integrin/Paxillin -0.017 0.073 -9999 0 -10000 0 0
lamellipodium assembly -0.003 0.033 -9999 0 -10000 0 0
PIK3CA 0.017 0 -9999 0 -10000 0 0
PI3K 0 0 -9999 0 -10000 0 0
ARF6 0.017 0 -9999 0 -10000 0 0
TLN1 0.017 0 -9999 0 -10000 0 0
PXN 0.031 0 -9999 0 -10000 0 0
PIK3R1 0.017 0 -9999 0 -10000 0 0
ARF6/GTP -0.004 0.034 -9999 0 -10000 0 0
cell adhesion -0.004 0.038 -9999 0 -10000 0 0
CRKL/CBL 0 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin -0.005 0.042 -9999 0 -10000 0 0
ITGB1 0.014 0.049 -9999 0 -0.72 1 1
ITGB7 -0.009 0.13 -9999 0 -0.63 9 9
ARF6/GDP 0.001 0.007 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/VCAM1 -0.011 0.067 -9999 0 -0.65 1 1
p130Cas/Crk/Dock1 -0.005 0.044 -9999 0 -0.38 3 3
VCAM1 0.002 0.096 -9999 0 -0.63 5 5
alpha4/beta1 Integrin/Paxillin/Talin -0.004 0.038 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 -0.004 0.038 -9999 0 -10000 0 0
BCAR1 0.017 0 -9999 0 -10000 0 0
mol:GDP 0.004 0.038 -9999 0 -10000 0 0
CBL 0.017 0 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
GIT1 0.017 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton -0.004 0.038 -9999 0 -10000 0 0
Rac1/GTP -0.003 0.036 -9999 0 -10000 0 0
E-cadherin signaling in keratinocytes

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.042 0.081 -9999 0 -10000 0 0
adherens junction organization -0.088 0.069 -9999 0 -0.39 6 6
mol:GTP 0 0 -9999 0 -10000 0 0
Rac1/GDP 0.038 0.11 -9999 0 -0.55 2 2
FMN1 0.028 0.068 -9999 0 -10000 0 0
mol:IP3 -0.026 0.082 -9999 0 -0.43 2 2
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.029 0.071 -9999 0 -10000 0 0
CTNNB1 -0.003 0.12 -9999 0 -0.72 6 6
AKT1 0.045 0.064 -9999 0 -10000 0 0
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.036 0.091 -9999 0 -0.49 1 1
CTNND1 0.017 0.005 -9999 0 -10000 0 0
mol:PI-4-5-P2 0.039 0.067 -9999 0 -10000 0 0
VASP 0.039 0.068 -9999 0 -10000 0 0
ZYX 0.037 0.073 -9999 0 -10000 0 0
JUB -0.35 0.1 -9999 0 -0.53 22 22
EGFR(dimer) 0.03 0.091 -9999 0 -0.48 1 1
E-cadherin/beta catenin-gamma catenin -0.02 0.095 -9999 0 -0.46 6 6
mol:PI-3-4-5-P3 -0.016 0.05 -9999 0 -10000 0 0
PIK3CA 0.017 0.005 -9999 0 -10000 0 0
PI3K -0.017 0.05 -9999 0 -10000 0 0
FYN 0.043 0.098 -9999 0 -0.49 1 1
mol:Ca2+ -0.026 0.081 -9999 0 -0.42 2 2
JUP 0.017 0.003 -9999 0 -10000 0 0
PIK3R1 0.017 0.005 -9999 0 -10000 0 0
mol:DAG -0.026 0.083 -9999 0 -0.43 2 2
CDH1 -0.001 0.1 -9999 0 -0.63 6 6
RhoA/GDP 0.038 0.11 -9999 0 -0.55 2 2
establishment of polarity of embryonic epithelium 0.039 0.067 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
RHOA 0.017 0 -9999 0 -10000 0 0
EGFR 0.002 0.099 -9999 0 -0.65 5 5
CASR 0.032 0.11 -9999 0 -0.45 4 4
RhoA/GTP -0.023 0.072 -9999 0 -10000 0 0
AKT2 0.045 0.064 -9999 0 -10000 0 0
actin cable formation 0.038 0.066 -9999 0 -10000 0 0
apoptosis 0.014 0.044 -9999 0 -10000 0 0
CTNNA1 0.017 0.005 -9999 0 -10000 0 0
mol:GDP 0.029 0.12 -9999 0 -0.6 2 2
PIP5K1A 0.039 0.068 -9999 0 -10000 0 0
PLCG1 -0.027 0.084 -9999 0 -0.44 2 2
Rac1/GTP -0.02 0.067 -9999 0 -0.44 1 1
homophilic cell adhesion 0.001 0.003 -9999 0 -10000 0 0
S1P4 pathway

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
GNAO1 0.017 0 -9999 0 -10000 0 0
CDC42/GTP -0.025 0.065 -9999 0 -10000 0 0
PLCG1 -0.012 0.14 -9999 0 -0.44 15 15
mol:GTP 0 0 -9999 0 -10000 0 0
GNAI2 0.017 0 -9999 0 -10000 0 0
GNAI3 0.017 0 -9999 0 -10000 0 0
G12/G13 0 0 -9999 0 -10000 0 0
cell migration -0.025 0.064 -9999 0 -10000 0 0
S1PR5 0 0 -9999 0 -10000 0 0
S1PR4 0 0 -9999 0 -10000 0 0
MAPK3 0.012 0.089 -9999 0 -10000 0 0
MAPK1 0.014 0.086 -9999 0 -0.31 1 1
S1P/S1P5/Gi 0.004 0.088 -9999 0 -10000 0 0
GNAI1 -0.07 0.22 -9999 0 -0.63 30 30
CDC42/GDP 0 0 -9999 0 -10000 0 0
S1P/S1P5/G12 0 0 -9999 0 -10000 0 0
RHOA 0.033 0 -9999 0 -10000 0 0
S1P/S1P4/Gi 0.004 0.088 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
GNAZ 0.017 0 -9999 0 -10000 0 0
S1P/S1P4/G12/G13 0 0 -9999 0 -10000 0 0
GNA12 0.017 0 -9999 0 -10000 0 0
GNA13 0.017 0 -9999 0 -10000 0 0
CDC42 0.017 0 -9999 0 -10000 0 0
Arf1 pathway

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex -0.013 0.065 -9999 0 -0.35 8 8
EntrezGene:79658 0 0 -9999 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A 0.024 0 -9999 0 -10000 0 0
AP2 0 0 -9999 0 -10000 0 0
mol:DAG 0 0 -9999 0 -10000 0 0
Arfaptin 2/Rac/GTP 0 0 -9999 0 -10000 0 0
CLTB 0.017 0 -9999 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ER cargo protein 0.034 0 -9999 0 -10000 0 0
CD4 0.017 0 -9999 0 -10000 0 0
CLTA 0.017 0 -9999 0 -10000 0 0
mol:GTP 0.001 0 -9999 0 -10000 0 0
ARFGAP1 -0.005 0.1 -9999 0 -0.55 8 8
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
ARF1/GTP 0 0 -9999 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein 0.022 0.076 -9999 0 -0.37 8 8
mol:Choline 0 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
ARF1 0.016 0 -9999 0 -10000 0 0
DDEF1 0 0.001 -9999 0 -10000 0 0
ARF1/GDP -0.014 0.074 -9999 0 -0.4 8 8
AP2M1 0.017 0 -9999 0 -10000 0 0
EntrezGene:1313 0 0 -9999 0 -10000 0 0
actin filament polymerization 0 0 -9999 0 -10000 0 0
Rac/GTP 0 0 -9999 0 -10000 0 0
ARF1/GTP/GGA3/ARF-GAP1 -0.014 0.075 -9999 0 -0.4 8 8
ARFIP2 0 0 -9999 0 -10000 0 0
COPA 0.017 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.032 0 -9999 0 -10000 0 0
ARF1/GTP/ARHGAP10 0 0 -9999 0 -10000 0 0
GGA3 0.017 0 -9999 0 -10000 0 0
ARF1/GTP/Membrin 0 0 -9999 0 -10000 0 0
AP2A1 0.017 0 -9999 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.028 0.044 -9999 0 -10000 0 0
ARF1/GDP/Membrin 0 0 -9999 0 -10000 0 0
Arfaptin 2/Rac/GDP 0 0 -9999 0 -10000 0 0
CYTH2 0.001 0 -9999 0 -10000 0 0
ARF1/GTP/GGA3 0 0 -9999 0 -10000 0 0
mol:ATP 0 0 -9999 0 -10000 0 0
Rac/GDP 0 0 -9999 0 -10000 0 0
mol:Brefeldin A 0 0 -9999 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.048 0 -9999 0 -10000 0 0
PLD2 0 0 -9999 0 -10000 0 0
ARF-GAP1/v-SNARE -0.005 0.1 -9999 0 -0.55 8 8
PIP5K1A 0 0 -9999 0 -10000 0 0
ARF1/GTP/Membrin/GBF1/p115 0 0 -9999 0 -10000 0 0
mol:Phosphatic acid 0 0 -9999 0 -10000 0 0
mol:Phosphatidic acid 0 0 -9999 0 -10000 0 0
KDEL Receptor/Ligand/ARF-GAP1 -0.005 0.1 -9999 0 -0.55 8 8
GOSR2 0 0 -9999 0 -10000 0 0
USO1 0 0 -9999 0 -10000 0 0
GBF1 0 0 -9999 0 -10000 0 0
ARF1/GTP/Arfaptin 2 0 0 -9999 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0 0 -9999 0 -10000 0 0
Aurora C signaling

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.007 0.085 -9999 0 -0.72 3 3
Aurora C/Aurora B/INCENP -0.006 0.048 -9999 0 -0.42 3 3
metaphase 0 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
H3F3B -0.001 0.013 -9999 0 -10000 0 0
AURKB 0.017 0 -9999 0 -10000 0 0
AURKC 0.017 0 -9999 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.003 0.032 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0 0 -9999 0 -10000 0 0
SUMO1 0.017 0 -9999 0 -10000 0 0
ZFPM1 0.017 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.024 0.034 -9999 0 -10000 0 0
FKBP3 0.017 0 -9999 0 -10000 0 0
Histones 0 0 -9999 0 -10000 0 0
YY1/LSF 0.035 0 -9999 0 -10000 0 0
SMG5 0.017 0 -9999 0 -10000 0 0
RAN 0.014 0.049 -9999 0 -0.72 1 1
I kappa B alpha/HDAC3 0 0 -9999 0 -10000 0 0
I kappa B alpha/HDAC1 0 0 -9999 0 -10000 0 0
SAP18 0.014 0.049 -9999 0 -0.72 1 1
RELA 0.053 0 -9999 0 -10000 0 0
HDAC1/Smad7 -0.002 0.026 -9999 0 -0.38 1 1
RANGAP1 0.004 0.098 -9999 0 -0.72 4 4
HDAC3/TR2 -0.007 0.054 -9999 0 -0.4 4 4
NuRD/MBD3 Complex 0.064 0.011 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0.055 0 -9999 0 -10000 0 0
EntrezGene:23225 0 0 -9999 0 -10000 0 0
GATA2 0.017 0 -9999 0 -10000 0 0
GATA1 0.014 0.049 -9999 0 -0.72 1 1
Mad/Max -0.025 0.1 -9999 0 -0.46 12 12
NuRD/MBD3 Complex/GATA1/Fog1 0.078 0.025 -9999 0 -10000 0 0
RBBP7 0.017 0 -9999 0 -10000 0 0
NPC -0.002 0.028 -9999 0 -0.42 1 1
RBBP4 0.017 0 -9999 0 -10000 0 0
MAX 0.017 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
FBXW11 0.017 0 -9999 0 -10000 0 0
NFKBIA 0.039 0 -9999 0 -10000 0 0
KAT2B 0 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
SIN3/HDAC complex 0.059 0.014 -9999 0 -10000 0 0
SIN3 complex -0.002 0.027 -9999 0 -10000 0 0
SMURF1 0.017 0 -9999 0 -10000 0 0
CHD3 0.014 0.049 -9999 0 -0.72 1 1
SAP30 0.017 0 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
NCOR1 0.014 0.043 -9999 0 -0.63 1 1
YY1/HDAC3 0 0 -9999 0 -10000 0 0
YY1/HDAC2 0.035 0 -9999 0 -10000 0 0
YY1/HDAC1 0.035 0 -9999 0 -10000 0 0
NuRD/MBD2 Complex (MeCP1) 0.063 0.019 -9999 0 -10000 0 0
PPARG -0.009 0.052 -9999 0 -10000 0 0
HDAC8/hEST1B 0 0 -9999 0 -10000 0 0
UBE2I 0.014 0.049 -9999 0 -0.72 1 1
beta TrCP1/SCF ubiquitin ligase complex 0.017 0 -9999 0 -10000 0 0
TNFRSF1A 0.017 0 -9999 0 -10000 0 0
HDAC3/SMRT (N-CoR2) 0 0 -9999 0 -10000 0 0
MBD3L2 0.017 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process -0.002 0.025 -9999 0 -0.38 1 1
CREBBP 0.017 0 -9999 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex 0.075 0.012 -9999 0 -10000 0 0
HDAC1 0.017 0 -9999 0 -10000 0 0
HDAC3 0.039 0 -9999 0 -10000 0 0
HDAC2 0.017 0 -9999 0 -10000 0 0
YY1 0.031 0 -9999 0 -10000 0 0
HDAC8 0.017 0 -9999 0 -10000 0 0
SMAD7 0.014 0.043 -9999 0 -0.63 1 1
NCOR2 0.017 0 -9999 0 -10000 0 0
MXD1 -0.018 0.15 -9999 0 -0.63 12 12
STAT3 0.035 0 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.014 0.049 -9999 0 -0.72 1 1
YY1/LSF/HDAC1 0 0 -9999 0 -10000 0 0
YY1/SAP30/HDAC1 0 0 -9999 0 -10000 0 0
EP300 0.017 0 -9999 0 -10000 0 0
STAT3 (dimer non-phopshorylated) 0.035 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.039 0 -9999 0 -10000 0 0
histone deacetylation 0.063 0.018 -9999 0 -10000 0 0
STAT3 (dimer non-phopshorylated)/HDAC3 0 0 -9999 0 -10000 0 0
nuclear export 0 0 -9999 0 -10000 0 0
PRKACA 0.017 0 -9999 0 -10000 0 0
GATAD2B 0.017 0 -9999 0 -10000 0 0
GATAD2A 0.017 0 -9999 0 -10000 0 0
GATA2/HDAC3 0 0 -9999 0 -10000 0 0
GATA1/HDAC1 -0.002 0.036 -9999 0 -0.54 1 1
GATA1/HDAC3 -0.002 0.027 -9999 0 -0.4 1 1
CHD4 0.017 0 -9999 0 -10000 0 0
TNF-alpha/TNFR1A 0 0 -9999 0 -10000 0 0
SIN3/HDAC complex/Mad/Max 0.053 0.051 -9999 0 -10000 0 0
NuRD Complex 0.074 0.02 -9999 0 -10000 0 0
positive regulation of chromatin silencing 0 0 -9999 0 -10000 0 0
SIN3B 0.017 0 -9999 0 -10000 0 0
MTA2 0.017 0 -9999 0 -10000 0 0
SIN3A 0.017 0 -9999 0 -10000 0 0
XPO1 0.017 0 -9999 0 -10000 0 0
SUMO1/HDAC1 -0.004 0.024 -9999 0 -10000 0 0
HDAC complex 0 0 -9999 0 -10000 0 0
GATA1/Fog1 -0.002 0.036 -9999 0 -0.54 1 1
FKBP25/HDAC1/HDAC2 0 0 -9999 0 -10000 0 0
TNF 0.017 0 -9999 0 -10000 0 0
negative regulation of cell growth 0.052 0.051 -9999 0 -10000 0 0
NuRD/MBD2/PRMT5 Complex 0.063 0.019 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 -0.005 0.032 -9999 0 -0.35 1 1
NF kappa B/RelA/I kappa B alpha 0 0 -9999 0 -10000 0 0
SIN3/HDAC complex/NCoR1 0.06 0.02 -9999 0 -10000 0 0
TFCP2 0.017 0 -9999 0 -10000 0 0
NR2C1 0.004 0.098 -9999 0 -0.72 4 4
MBD3 0.017 0 -9999 0 -10000 0 0
MBD2 0.014 0.043 -9999 0 -0.63 1 1
Atypical NF-kappaB pathway

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0 0 -9999 0 -10000 0 0
FBXW11 0.017 0 -9999 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.034 0.033 -9999 0 -0.46 1 1
NF kappa B1 p50/RelA/I kappa B alpha 0.061 0.035 -9999 0 -10000 0 0
NFKBIA 0.038 0.026 -9999 0 -10000 0 0
MAPK14 0.017 0 -9999 0 -10000 0 0
NF kappa B1 p105/p50 0.034 0.033 -9999 0 -0.46 1 1
ARRB2 0.023 0 -9999 0 -10000 0 0
REL 0.017 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
BCL3/NF kappa B1 p50 0.034 0.033 -9999 0 -0.46 1 1
response to UV 0 0 -9999 0 -10000 0 0
NF kappa B1 p105/RelA 0.034 0.033 -9999 0 -0.46 1 1
PIK3CA 0.017 0 -9999 0 -10000 0 0
NF kappa B1 p50 dimer 0.025 0.038 -9999 0 -0.54 1 1
PIK3R1 0.017 0 -9999 0 -10000 0 0
NFKB1 0.029 0.038 -9999 0 -0.54 1 1
RELA 0.017 0 -9999 0 -10000 0 0
positive regulation of anti-apoptosis 0.046 0.029 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.065 0.034 -9999 0 -10000 0 0
SRC 0.017 0 -9999 0 -10000 0 0
PI3K 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0.046 0.029 -9999 0 -10000 0 0
IKBKB 0.014 0.049 -9999 0 -0.72 1 1
beta TrCP1/SCF ubiquitin ligase complex 0.017 0 -9999 0 -10000 0 0
SYK 0.014 0.049 -9999 0 -0.72 1 1
I kappa B alpha/PIK3R1 0.044 0.024 -9999 0 -10000 0 0
cell death -0.003 0.025 -9999 0 -10000 0 0
NF kappa B1 p105/c-Rel 0.034 0.033 -9999 0 -0.46 1 1
LCK 0.011 0.065 -9999 0 -0.68 2 2
BCL3 0.017 0 -9999 0 -10000 0 0
Sumoylation by RanBP2 regulates transcriptional repression

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.005 0.031 -9999 0 -10000 0 0
MDM2/SUMO1 -0.004 0.024 -9999 0 -10000 0 0
HDAC4 0.017 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.005 0.031 -9999 0 -10000 0 0
SUMO1 0.017 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1 0.018 0.037 -9999 0 -0.23 4 4
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 0.034 0.032 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.014 0.049 -9999 0 -0.72 1 1
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.014 0.049 -9999 0 -0.72 1 1
SUMO1/HDAC4 -0.004 0.024 -9999 0 -10000 0 0
SUMO1/HDAC1 -0.004 0.024 -9999 0 -10000 0 0
RANGAP1 0.004 0.098 -9999 0 -0.72 4 4
MDM2/SUMO1/SUMO1 -0.002 0.027 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 0.024 0.034 -9999 0 -10000 0 0
Ran/GTP -0.006 0.035 -9999 0 -0.37 1 1
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.017 0 -9999 0 -10000 0 0
UBE2I 0.014 0.049 -9999 0 -0.72 1 1
Ran/GTP/Exportin 1 -0.005 0.032 -9999 0 -0.35 1 1
NPC -0.002 0.028 -9999 0 -0.42 1 1
PIAS2 0.014 0.049 -9999 0 -0.72 1 1
PIAS1 0.017 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
Rapid glucocorticoid signaling

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0 0 -9999 0 -10000 0 0
MAPK9 0.012 0 -9999 0 -10000 0 0
adrenocorticotropin secretion 0.013 0.038 -9999 0 -0.55 1 1
GNB1/GNG2 0 0 -9999 0 -10000 0 0
GNB1 0.017 0 -9999 0 -10000 0 0
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
MAPK14 0.012 0 -9999 0 -10000 0 0
Gs family/GTP 0 0 -9999 0 -10000 0 0
EntrezGene:2778 0 0 -9999 0 -10000 0 0
vasopressin secretion 0 0 -9999 0 -10000 0 0
G-protein coupled receptor activity 0 0 -9999 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -9999 0 -10000 0 0
glutamate secretion 0 0 -9999 0 -10000 0 0
GNAL 0.017 0 -9999 0 -10000 0 0
GNG2 0.017 0 -9999 0 -10000 0 0
CRH 0.014 0.049 -9999 0 -0.72 1 1
mol:cortisol 0 0 -9999 0 -10000 0 0
MAPK8 0.012 0 -9999 0 -10000 0 0
MAPK11 0.01 0.022 -9999 0 -0.32 1 1
Class IB PI3K non-lipid kinase events

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process -0.017 0 -9999 0 -9999 0 0
PI3K Class IB/PDE3B 0.017 0 -9999 0 -9999 0 0
PDE3B 0.017 0 -9999 0 -9999 0 0
p38 MAPK signaling pathway

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 -0.004 0.037 -9999 0 -0.4 2 2
TRAF2/ASK1 -0.004 0.044 -9999 0 -0.47 2 2
ATM 0.017 0 -9999 0 -10000 0 0
MAP2K3 0.064 0.023 -9999 0 -10000 0 0
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 0.059 0.055 -9999 0 -10000 0 0
hyperosmotic response 0 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
GADD45G 0 0.11 -9999 0 -0.72 5 5
TXN 0.012 0 -9999 0 -10000 0 0
CALM1 0.017 0 -9999 0 -10000 0 0
GADD45A 0.01 0.07 -9999 0 -0.72 2 2
GADD45B 0.017 0 -9999 0 -10000 0 0
MAP3K1 0.017 0 -9999 0 -10000 0 0
MAP3K6 0.017 0 -9999 0 -10000 0 0
MAP3K7 0.017 0 -9999 0 -10000 0 0
MAP3K4 0.017 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
ASK1/ASK2 -0.005 0.051 -9999 0 -0.54 2 2
TAK1/TAB family 0.001 0.013 -9999 0 -10000 0 0
RAC1/OSM/MEKK3 0 0 -9999 0 -10000 0 0
TRAF2 0.017 0 -9999 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 -0.001 0.008 -9999 0 -10000 0 0
TRAF6 0.023 0 -9999 0 -10000 0 0
RAC1 0.017 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
CAMK2B 0.014 0.049 -9999 0 -0.72 1 1
CCM2 0.017 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB -0.002 0.031 -9999 0 -0.47 1 1
MAPK11 0.014 0.049 -9999 0 -0.72 1 1
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 -0.006 0.048 -9999 0 -0.42 3 3
OSM/MEKK3 0 0 -9999 0 -10000 0 0
TAOK1 0.022 0.026 -9999 0 -0.37 1 1
TAOK2 0.023 0 -9999 0 -10000 0 0
TAOK3 0.023 0 -9999 0 -10000 0 0
MAP3K7IP1 0.017 0 -9999 0 -10000 0 0
MAPK14 0.017 0 -9999 0 -10000 0 0
MAP3K7IP2 0.017 0 -9999 0 -10000 0 0
MAP3K5 0.01 0.07 -9999 0 -0.72 2 2
MAP3K10 0.014 0.049 -9999 0 -0.72 1 1
MAP3K3 0.017 0 -9999 0 -10000 0 0
TRX/ASK1 0.017 0.045 -9999 0 -0.46 2 2
GADD45/MTK1/MTK1 -0.012 0.067 -9999 0 -10000 0 0
Alternative NF-kappaB pathway

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0 0 -9999 0 -10000 0 0
FBXW11 0.017 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.017 0 -9999 0 -10000 0 0
CHUK 0.017 0 -9999 0 -10000 0 0
NF kappa B2 p100/RelB -0.002 0.025 -9999 0 -10000 0 0
NFKB1 0.017 0 -9999 0 -10000 0 0
MAP3K14 0.017 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelB 0 0 -9999 0 -10000 0 0
RELB 0.017 0 -9999 0 -10000 0 0
NFKB2 0.014 0.049 -9999 0 -0.72 1 1
NF kappa B2 p52/RelB -0.002 0.031 -9999 0 -0.47 1 1
regulation of B cell activation -0.002 0.031 -9999 0 -0.46 1 1
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 224 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.AY.4071 TCGA.AY.4070 TCGA.AG.A032 TCGA.AG.A02X
109_MAP3K5 0.075 0.075 -0.089 -0.31
47_PPARGC1A 0.017 -0.63 0.017 -0.63
105_BMP4 0.017 0.017 0.017 0.017
105_BMP6 0.017 0.017 -0.63 -0.63
105_BMP7 0.017 -0.72 -0.72 0.017
105_BMP2 0.017 0.017 0.017 0.017
131_RELN/VLDLR -0.75 -0.41 -0.41 -0.41
30_TGFB1/TGF beta receptor Type II 0.016 0.021 0.016 0.016
84_STAT5B -0.087 -0.16 -0.14 0.054
84_STAT5A -0.087 -0.16 -0.14 0.054
Methods & Data
Input

  • Expression Data Normalization = Normal controls were used to median center the expression data used in this analysis.

  • mRNA Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_MergeDataFilesPipeline/COADREAD-TP/2599654/2.GDAC_MergeDataFiles.Finished/COADREAD-TP.transcriptome__agilentg4502a_07_3__unc_edu__Level_3__unc_lowess_normalization_gene_level__data.data.txt

  • Copy Number File Used = Copy number data was not used in this analysis.

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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